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Mobilization And Partisan Identities: A Comparative Study Of Partisanship Under Compulsory And Voluntary Voting, Eli Gavin Rau Oct 2021

Mobilization And Partisan Identities: A Comparative Study Of Partisanship Under Compulsory And Voluntary Voting, Eli Gavin Rau

Yale Graduate School of Arts and Sciences Dissertations

Partisan identification is intimately related to many central aspects of political behavior. It influences vote choice, voters’ policy positions, and the manner in which voters process new political information. Partisanship has the power to undermine politicians’ accountability and it can even trump voters’ democratic values in polarized societies. Yet large gaps remain in our understanding of the relationship between partisanship and another key subject of political behavior: voter participation. We know that partisans are more likely to turn out to vote than their non-partisan counterparts; but why are partisans more likely to turn out? Are partisans simply people who are …

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Cost-Effectiveness Analyses Of Typhoid Interventions In Epidemic And Endemic Settings, Maile Thayer Phillips Oct 2021

Cost-Effectiveness Analyses Of Typhoid Interventions In Epidemic And Endemic Settings, Maile Thayer Phillips

Yale Graduate School of Arts and Sciences Dissertations

Background: Typhoid fever is a major source of morbidity and mortality in developing countries, accounting for approximately 12-21 million infections, 119,000-269,000 deaths, and 2-23 million disability-adjusted life years (DALYs) annually. Typhoid fever is caused by infection with the bacteria Salmonella enterica serovar Typhi, which is mainly transmitted through fecal contamination of food or water. Due to these modes of transmission, most cases occur in low- and middle-income countries (LMICs) where sanitary conditions are poor and access to clean water and sanitation is not common. However, the scale of disease incidence is uncertain. Studies suggest that facility-based laboratory-confirmed estimates, the numbers …

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A Hybrid Sdn-Based Architecture For Wireless Networks, Qiaofeng Qin Oct 2021

A Hybrid Sdn-Based Architecture For Wireless Networks, Qiaofeng Qin

Yale Graduate School of Arts and Sciences Dissertations

With new possibilities brought by the Internet of Things (IoT) and edge computing, the traffic demand of wireless networks increases dramatically. A more sophisticated network management framework is required to handle the flow routing and resource allocation for different users and services. By separating the network control and data planes, Software-defined Networking (SDN) brings flexible and programmable network control, which is considered as an appropriate solution in this scenario.Although SDN has been applied in traditional networks such as data centers with great successes, several unique challenges exist in the wireless environment. Compared with wired networks, wireless links have limited capacity. …

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Development Of The Nuclear-Electronic Orbital Method For Applications To Molecular Electrocatalyst Systems, Patrick Schneider Oct 2021

Development Of The Nuclear-Electronic Orbital Method For Applications To Molecular Electrocatalyst Systems, Patrick Schneider

Yale Graduate School of Arts and Sciences Dissertations

Studies of molecular electrocatalysts often involve input from quantum chemical computations in the pursuit of catalyst design targeting several desirable features. To this end, conventional density functional theory (DFT) calculations have proven to be a good match with a reasonable balance between computational accuracy and cost. However, a multicomponent method that treats select nuclei on the same quantum mechanical level as electrons would be useful for a more proper treatment of nuclear quantum effects. Such a multicomponent DFT method has been developed in recent years within the nuclear-electronic orbital (NEO) framework. However, for the multicomponent method to be practically applied …

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Computational Investigations Of The Oxygen-Evolving Complex And Its Water Network, Krystle M. Reiss Oct 2021

Computational Investigations Of The Oxygen-Evolving Complex And Its Water Network, Krystle M. Reiss

Yale Graduate School of Arts and Sciences Dissertations

To oxidize two waters into molecular oxygen, the OEC requires channels via which it can bring in new substrate waters and release protons through PCET as the manganese centers are oxidized. Three water channels surround the OEC: the narrow, broad, and large. Each channel possesses its own unique set of properties that make it ideal for a different purpose. Using network analysis and novel occupancy analysis, the stability of each channel's water positions and hydrogen bond network was quantified, showing the stark differences between the channels. The narrow channel is very sensitive to the oxidation of Mn4, appearing to prepare …

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Minimizing Tracer Interference To Assess In Vivo Hepatic Metabolism With Glutamine-Generated Mass Isotopomers, Stephan Siebel Oct 2021

Minimizing Tracer Interference To Assess In Vivo Hepatic Metabolism With Glutamine-Generated Mass Isotopomers, Stephan Siebel

Yale Graduate School of Arts and Sciences Dissertations

Stable isotope tracers are widely used to study the in vivo kinetics of central carbon metabolism in diseases such as obesity, type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). However, despite their common use, 13C-labeled acetate, lactate, and propionate have led to large incongruities and inconsistencies in their in vivo measurement of hepatic metabolism. To resolve major discrepancies and recent controversies of hepatic metabolism we developed and validated [1,2-13C2]-L-glutamine as a novel tracer strategy for measuring hepatic central carbon metabolism. In our rodent studies [1,2-13C2]-L-glutamine generated a straightforward labeling pattern of key metabolites suitable for the interpretation …

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Synthetic Studies Towards The Total Synthesis Of (–)-Lomaiviticin A, John A. Rose Oct 2021

Synthetic Studies Towards The Total Synthesis Of (–)-Lomaiviticin A, John A. Rose

Yale Graduate School of Arts and Sciences Dissertations

(–)-Lomaiviticin A (1) is a complex C2-symmetric bacterial metabolite which was isolated from a fermentation broth of Salinispora DPJ-19 by He and co-workers in 2001. The structure of 1 was proposed through detailed analysis of NMR spectral data (Figure 1). Due to the presence of a diazotetrahydrobenzo[b]fluorene substructure, 1 belongs to a family of natural products often referred to as “diazofluorenes” among which the kinamycins (A, C, and F seen in Figure 1) are the earliest known members. (–)-Lomaiviticin A (1) is the most cytotoxic member of the diazofluorene family known with half maximal inhibitory potencies (IC50S) in the nanomolar …

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Social Control And Incarceration In Lesotho: A History Of Strategies, 1850-1970, Samuel John Severson Oct 2021

Social Control And Incarceration In Lesotho: A History Of Strategies, 1850-1970, Samuel John Severson

Yale Graduate School of Arts and Sciences Dissertations

This dissertation explores how technologies and infrastructures for promoting control and cohesion have interfaced with the social and political history of Lesotho over the longue durée. This approach allows for tracing lines of historical continuity and change during a period spanning the coalescing of the nation from communities on the Southern African Highveld in the early-19th century, the onset and grinding realities of British colonial rule and the rise of a local economy dependent on labor migration to South Africa, and the unravelling of empire and the challenges of governance in the years following official national liberation in 1966. I …

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Novel Signal Reconstruction Techniques In Cyclotron Radiation Emission Spectroscopy For Neutrino Mass Measurement, Luis Elias Saldana Oct 2021

Novel Signal Reconstruction Techniques In Cyclotron Radiation Emission Spectroscopy For Neutrino Mass Measurement, Luis Elias Saldana

Yale Graduate School of Arts and Sciences Dissertations

The Project 8 experiment is developing Cyclotron Radiation Emission Spectroscopy (CRES) on the beta-decay spectrum of tritium for the measurement of the absolute neutrino mass scale. CRES is a frequency-based technique which aims to probe the endpoint of the tritium energy spectrum with a final target sensitivity of 0.04 eV, pushing the limits beyond the inverted mass hierarchy. A phased-approach experiment, both Phase I and Phase II efforts use a combination of 83mKr and molecular tritium T_2 as source gases. The technique relies on an accurate, precise, and well-understood reconstructed beta-spectrum whose endpoint and spectral shape near the endpoint may …

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Interactions Among Species And Ecosystems Determine Their Responses To Scale-Specific Fluctuations, Franz Wesley Simon Oct 2021

Interactions Among Species And Ecosystems Determine Their Responses To Scale-Specific Fluctuations, Franz Wesley Simon

Yale Graduate School of Arts and Sciences Dissertations

Ecosystems are highly connected systems with many interacting components. Understanding the mechanisms creating ecosystem patterns requires an explicit consideration of the scales at which interactions among species and their environments occur. This dissertation focuses on the scale of temporal variability and how temporal variability is incorporated into communities’ dynamics. I first derive an abstract theory that describes the general patterns of variability propagation within communities. Next, I explore the role of species’ interaction strengths on community dynamics across time scales. Finally, I study the impact of human-induced hydrological changes of the Guadalquivir River on the European anchovy fishery in the …

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Synergistic Action Of Synaptotagmin Family In Neurotransmitter Release., Ekaterina Stroeva Oct 2021

Synergistic Action Of Synaptotagmin Family In Neurotransmitter Release., Ekaterina Stroeva

Yale Graduate School of Arts and Sciences Dissertations

The overarching theme of my thesis work is centered around the understanding of how the Synaptotagmin (Syt) family of proteins, which are key players in neurotransmission, is regulated in the brain. Upon very briefly introducing other key molecular players, firstly, I summarize the discovery of the regulation of Syts by self-oligomerization. This work is focused on the characterization of the physiologically relevant Syt1 ring-like oligomers, which are formed in the presence of negatively charged lipids and dissociate upon calcium binding. Using the approach of hypothetical structure-guided mutagenesis, phenylalanine in position 349 is identified as critical for the oligomer formation. Importantly, …

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Biological Mechanisms Linking Stress And Anhedonia, Colin Stanton Oct 2021

Biological Mechanisms Linking Stress And Anhedonia, Colin Stanton

Yale Graduate School of Arts and Sciences Dissertations

Evidence from research across species suggests that stress exposure is linked with anhedonia (loss of pleasure and/or decreased motivation). However, the mechanisms through which stress might impact anhedonia remain unclear. Chapters 1 and 2 of this dissertation review putative etiological pathways from stress to anhedonia and discuss stressor characteristics that could inform experimental models of stress-induced anhedonia. Chapter 3 describes an attempt to identify which types of stress are most associated with anhedonia using stress interview data from multiple datasets. Unexpectedly, we found no credible effects on anhedonic symptoms for stressor chronicity, severity, dependence on behavior, or interpersonal focus. Instead, …

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Specifying And Targeting Cognitive-Affective Dysfunctions In Antisocial Individuals, Allison Mary Stuppy-Sullivan Oct 2021

Specifying And Targeting Cognitive-Affective Dysfunctions In Antisocial Individuals, Allison Mary Stuppy-Sullivan

Yale Graduate School of Arts and Sciences Dissertations

Antisocial behavior includes a wide range of behaviors that violate social norms, from criminal acts to substance misuse. The adverse consequences of antisocial behavior produce a great physical and emotional burden on perpetrators, victims, and family members. This burden is not addressed adequately, with incarceration being the most common intervention for antisocial behavior. When individuals who chronically engage in antisocial behavior are offered therapeutic treatments, the majority neither complete nor benefit from them. One reason existing treatments do not fully address antisocial behavior is because they do not consider or target cognitive-affective dysfunctions driving such behavior, and mechanistic research, to …

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Proteome-Wide Screening For Mitogen-Activated Protein Kinase Docking Motifs And Interactors, Guangda Shi Oct 2021

Proteome-Wide Screening For Mitogen-Activated Protein Kinase Docking Motifs And Interactors, Guangda Shi

Yale Graduate School of Arts and Sciences Dissertations

AbstractProteome-wide screening for mitogen-activated protein kinase docking motifs and interactors Guangda Shi 2021 Kinases catalyze the transfer of phosphate to substrates, a reaction critical for many cellular events. Mitogen-activated protein kinases (MAPKs), including ERK, p38, and JNK, phosphorylate hundreds of substrates, and each plays a pivotal role in distinct processes such as cell growth, survival, differentiation, and apoptosis. To correctly respond to external stimuli, MAPKs use several mechanisms to achieve a high degree of selectivity for their target substrates. A critical aspect of MAPK specificity comes from docking interactions occurring between sites distal from the site of catalysis and short …

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On The Role Of Stability In Animal Morphology And Neural Control, Neelima Sharma Oct 2021

On The Role Of Stability In Animal Morphology And Neural Control, Neelima Sharma

Yale Graduate School of Arts and Sciences Dissertations

Mechanical stability is vital for the fitness and survival of animals and is a crucial aspect of robot design and control. Stability depends on multiple factors, including the body's intrinsic mechanical response and feedback control. But feedback control is more fragile than the body's innate mechanical response or open-loop control strategies because of sensory noise and time-delays in feedback. This thesis examines the overarching hypothesis that stability demands have played a crucial role in how animal form and function arise through natural selection and motor learning. In two examples, finger contact and overall body stability, we investigated the relationship between …

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Characterizing Photophysics Of Photoconvertible-Fluorescent Protein Meos3.2 For Quantitative Fluorescence Microscopy, Mengyuan Sun Oct 2021

Characterizing Photophysics Of Photoconvertible-Fluorescent Protein Meos3.2 For Quantitative Fluorescence Microscopy, Mengyuan Sun

Yale Graduate School of Arts and Sciences Dissertations

Photoconvertible fluorescent proteins (PCFPs) are widely used in super-resolution microscopy, and studies of cellular dynamics. Their photoconversion properties have enabled single-molecule localization microscopy (SMLM) by temporally separating closely-spaced molecules. However, our understanding of their photophysics is still limited, hampering their quantitative application. For example, counting fluorescently-tagged fusion proteins from the discrete localizations of individual molecules is still difficult. The red-to-green photoconvertible fluorescent protein mEos3.2 is favored by many due to its monomeric property, high brightness, photostability, compatibility with live cells, and 1:1 labeling stoichiometry. The fluorescent protein mEos3.2 is fused to the coding sequence of a protein of interest in …

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Immune Activation By Novel Allobaculum Species Reveals Reciprocal Epistasis Among Human Gut Commensals, Tyler A. Rice Oct 2021

Immune Activation By Novel Allobaculum Species Reveals Reciprocal Epistasis Among Human Gut Commensals, Tyler A. Rice

Yale Graduate School of Arts and Sciences Dissertations

Gut commensal microbes that elicit human immune responses are noteworthy for their ability to influence both local mucosal inflammation and, more rarely, systemic antibody responses. Here we isolated and characterized novel strains belonging to genus Allobaculum from inflammatory bowel disease (IBD) stool samples. In defined gnotobiotic mouse models we recapitulated the inflammatory effects of Allobaculum sps. and their notable induction of systemic immune responses at baseline. A microbial ecology screen revealed that this taxon is inversely correlated with Akkermansia muciniphila, and co-colonization experiments uncovered microbe-dependent redirection of immune phenotypes, which we term reciprocal epistasis. These immunostimulatory gut commensal strains exemplify …

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Regulation Of Tim-3 By Phosphatidylserine, Courtney Mccaul Smith Oct 2021

Regulation Of Tim-3 By Phosphatidylserine, Courtney Mccaul Smith

Yale Graduate School of Arts and Sciences Dissertations

TIM-3, or T cell, immunoglobulin, and mucin domain-containing protein-3, is a transmembrane glycoprotein expressed by several types of immune cells, including T cells, making it an important regulator of the immune response. However, the biology of TIM-3 is complicated, as it has been shown to variously promote and inhibit the function of T cells and other immune cells. Understanding the contexts in which TIM-3 serves these dual roles has remained difficult, as the ligands that regulate the activity of this receptor are still unclear. Several molecules have been proposed to regulate TIM-3, including phosphatidylserine (PS), galectin-9, carcinoembryonic antigen-related cell adhesion …

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Structural Studies On Mechanisms Of Samhd1 Function And Dysfunction, Joshua Temple Oct 2021

Structural Studies On Mechanisms Of Samhd1 Function And Dysfunction, Joshua Temple

Yale Graduate School of Arts and Sciences Dissertations

Sterile α-motif and HD domain-containing protein 1 (SAMHD1) is a pivotal enzyme that maintains cellular nucleotide homeostasis. SAMHD1 forms a tetramer upon binding GTP and a dNTP at allosteric sites, activating its triphosphohydrolase activity against substrate deoxynucleoside triphosphates (dNTPs). This dNTPase activity, in combination with other functions in DNA repair, cell cycle regulation, and nucleic acid binding, is important to other facets of SAMHD1 biology as a critical mediator of antiviral defense, cancer suppression, and autoimmune regulation. An array of post-translational modifications on SAMHD1 present an additional layer of functional regulation – most notably phosphorylation at residue T592, a master …

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Leveraging New Technologies And Interdisciplinarity To Study Political Behavior, Attitudes, And Beliefs, John Ternovski Oct 2021

Leveraging New Technologies And Interdisciplinarity To Study Political Behavior, Attitudes, And Beliefs, John Ternovski

Yale Graduate School of Arts and Sciences Dissertations

I make use of new technological and scholarly developments to study political sentiments and behavior in three independent papers. In my lead paper, I address an important consequence of political deepfakes (i.e., computer-manipulated video misinformation): does the provision of information about deepfakes cause people to disbelieve real political videos? Through a set of online survey experiments, I find that information that is typical of news coverage of deepfakes induces people to disbelieve real political information. My second paper uses new social media datasets to address pressing questions about how organized American far-right groups (e.g., neo-Nazis, white supremacists, etc.) recruit new …

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Development Of Diverse Bifunctional Molecules For Interrogating Dcps, Her3, Brachyury, And Phosphorylation-Driven Diseases Towards Therapeutic Applications, Jake Charles Swartzel Oct 2021

Development Of Diverse Bifunctional Molecules For Interrogating Dcps, Her3, Brachyury, And Phosphorylation-Driven Diseases Towards Therapeutic Applications, Jake Charles Swartzel

Yale Graduate School of Arts and Sciences Dissertations

Technologies that hijack cellular pathways using bifunctional small molecules have recently risen to the forefront of the drug discovery world. The first targeted protein degradation (TPD) technology to be developed, PROteolysis Targeting Chimeras (PROTACs), were disclosed two decades ago. The recent successes of AR and ER-degrading PROTACs in pioneering clinical trials has propelled interest in developing novel platforms to further expand the druggable proteome and the arsenal of strategies that are available for therapeutic intervention. This thesis is focused on the development of novel bifunctional molecules that enable interrogation of diseases driven by traditionally challenging protein targets. The first chapter …

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Elucidating The Molecular Mechanism Of Cis-Regulation By The Long Noncoding Rna Lincrna-P21, Lauren Nicole Winkler Oct 2021

Elucidating The Molecular Mechanism Of Cis-Regulation By The Long Noncoding Rna Lincrna-P21, Lauren Nicole Winkler

Yale Graduate School of Arts and Sciences Dissertations

Pervasive transcription is a hallmark of mammalian genomes. Although protein-coding genes span only a small fraction of the genome, more than two-thirds is transcribed, yielding thousands of noncoding transcripts whose expression exhibits a tight correlation with cell type, disease state, and other biological phenomena. A subset of these transcripts, termed long noncoding RNAs (lncRNAs) on account of their length (>200 nucleotides) and lack of apparent coding potential, have been shown to play functional roles in processes ranging from immune signaling to organogenesis. In contrast to trans-acting lncRNAs, which may operate in either the nucleus or cytoplasm, cis-acting lncRNAs remain …

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Commerce And Justice: Ottoman And Venetian Courts In Istanbul During The Seventeenth Century, Tommaso Stefini Oct 2021

Commerce And Justice: Ottoman And Venetian Courts In Istanbul During The Seventeenth Century, Tommaso Stefini

Yale Graduate School of Arts and Sciences Dissertations

"Commerce and Justice: Ottoman and Venetian Courts in Istanbul during the Seventeenth Century” analyzes legal disputes and economic transactions between Ottoman and Venetian merchants in Istanbul on a daily basis between 1600 and1620. At that time, the Venetians constituted the largest European community in the Ottoman capital, and they engaged intensively in trade ventures with Ottoman businessmen belonging to different religious and ethnic communities, including Muslim Turks, Sephardic Jews, and Orthodox Greeks. This dissertation asks how Ottomans and Venetians cooperated in commercial undertakings and solved controversies despite the absence of a system of inter-polity law and secular legal regimes in …

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Graph Priors, Optimal Transport, And Deep Learning In Biomedical Discovery, Alexander Tong Oct 2021

Graph Priors, Optimal Transport, And Deep Learning In Biomedical Discovery, Alexander Tong

Yale Graduate School of Arts and Sciences Dissertations

Recent advances in biomedical data collection allows the collection of massive datasets measuring thousands of features in thousands to millions of individual cells. This data has the potential to advance our understanding of biological mechanisms at a previously impossible resolution. However, there are few methods to understand data of this scale and type. While neural networks have made tremendous progress on supervised learning problems, there is still much work to be done in making them useful for discovery in data with more difficult to represent supervision. The flexibility and expressiveness of neural networks is sometimes a hindrance in these less …

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Learning, Optimization And Data Translation With Deep Neural Networks, Ganlin Song Oct 2021

Learning, Optimization And Data Translation With Deep Neural Networks, Ganlin Song

Yale Graduate School of Arts and Sciences Dissertations

Neural networks have been intensively studied as machine learning models and widely applied in various areas. This thesis investigates three problems related to the theory and application of neural networks. First, we analyze a learning scheme for neural networks that uses random weights in the backpropagation training algorithm, which is considered to be more biologically plausible than the standard training procedure. We establish theory that shows the convergence of the loss and the alignment between the forward weights of the network and the random weights used in the backward pass. Second, we study a family of optimization problems where the …

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Craft And Storytelling: Romance And Reality In Joseph Conrad And Gabriel García Márquez, Camila Velez Valencia Oct 2021

Craft And Storytelling: Romance And Reality In Joseph Conrad And Gabriel García Márquez, Camila Velez Valencia

Yale Graduate School of Arts and Sciences Dissertations

This dissertation describes how the novels, novellas and short stories of Joseph Conrad and Gabriel García Márquez subvert the conventions of the European realist novel and indeed the quotidian world of real facts itself in favor of a romance grounded in everyday experience. In their fictions, Conrad’s and García Márquez’s narrators trace the apparition of the wonderful in an otherwise realistic world through their mastery of craft and its concomitant vernaculars. They draw on the tropes of the traditional romance—digression, repetition and chance—to reenchant disenchanted worlds, to reconstrue the strange. They borrow the skills of the oral storyteller—craftsmanship, gesture and …

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Development Of Enantioselective Synthetic Routes To (–)-Myrocin G And (–)-Euonyminol., Martin Tomanik Oct 2021

Development Of Enantioselective Synthetic Routes To (–)-Myrocin G And (–)-Euonyminol., Martin Tomanik

Yale Graduate School of Arts and Sciences Dissertations

In the first chapter, I describe the development of a synthetic strategy towards (–)-myrocin G (8), the putative active form of the antiproliferative fungal metabolite (+)-myrocin C (4). Myrocin C (4) has been proposed to cross-link DNA by two-fold nucleotide addition; however, this proposed bioalkylation hypothesis has not been tested with native DNA. Our synthetic efforts provided a highly convergent total synthesis of myrocin G (8) in 15 steps from simple starting materials. A key steps in the sequence involved a carefully designed fragment coupling–cyclization cascade (see 85 + 89 → 90). This transformation effectively unites the iodocyclopropane 85 with …

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Three Essays In Environmental And Transportation Economics, Stephanie Margalit Weber Oct 2021

Three Essays In Environmental And Transportation Economics, Stephanie Margalit Weber

Yale Graduate School of Arts and Sciences Dissertations

The transportation sector contributes around 30% of US greenhouse gas emissions, and reducing these emissions is an important part of any large-scale climate policy. This dissertation examines three questions about policies and programs designed to reduce emissions from heavy-duty trucks and cars, using a range of economic data and methodologies.The first chapter considers the recent federal fuel efficiency standards for heavy-duty trucks, which mandated that the average fuel efficiency of trucks sold by each manufacturer reach certain levels. To estimate the welfare implications of the policy, I develop a model of supply and demand in the sector using detailed data …

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Electrochemical Hydrogen Peroxide Generation With Anthraquinone Chemistry For Advanced Oxidation Process, Qianhong Zhu Oct 2021

Electrochemical Hydrogen Peroxide Generation With Anthraquinone Chemistry For Advanced Oxidation Process, Qianhong Zhu

Yale Graduate School of Arts and Sciences Dissertations

Hydrogen peroxide plays a critical role in many industrial applications, including chemical synthesis and environmental remediation. For example, in advanced oxidation process of water treatment, hydrogen peroxide is activated to hydroxyl radical by catalysts or UV light for non-selective and rapid degradation of non-biodegradable, toxic, recalcitrant organic micropollutants. Industrial anthraquinone process, which synthesizes hydrogen peroxide from hydrogen and oxygen gas in organic phase, requires intensive capital investment, expensive reactants, high energy inputs, and raises many environmental concerns. Electrochemical production of hydrogen peroxide with air, water and electricity as inputs has emerged as a promising alternative method because it is low-cost, …

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Linguistic Variation From Cognitive Variability: The Case Of English 'Have', Muye Zhang Oct 2021

Linguistic Variation From Cognitive Variability: The Case Of English 'Have', Muye Zhang

Yale Graduate School of Arts and Sciences Dissertations

In this dissertation, I seek to construct a model of meaning variation built upon variability in linguistic structure, conceptual structure, and cognitive makeup, and in doing so, exemplify an approach to studying meaning that is both linguistically principled and neuropsychologically grounded. As my test case, I make use of the English lexical item 'have' by proposing a novel analysis of its meaning based on its well-described variability in English and its embedding into crosslinguistically consistent patterns of variation and change. I support this analysis by investigating its real-time comprehension patterns through behavioral, electropsychophysiological, and hemodynamic brain data, thereby incorporating dimensions …

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