Digital Commons Network^™

The Regulation Of Mitochondrial Uncoupling Proteins In The Heart, Karl Robert Laskowski

Yale Medicine Thesis Digital Library

The mitochondrial uncoupling proteins (UCPs) are a recently discovered group of proteins that are present in the inner mitochondrial membrane and mediate a variety of important functions. Involved in transmembrane proton transport, UCPs regulate cellular metabolism as well as prevent reactive oxygen species formation (ROS) and detoxify exogenous ROS. In the heart, these proteins may protect tissue during times of ischemic or metabolic stress. Also activated during metabolic stress is AMP-activated protein kinase (AMPK), which has been shown to provide cardioprotection during ischemia/reperfusion. We hypothesized that AMPK activation plays a role in upregulating the expression of uncoupling proteins UCP2 and …

The Uses Of Rickets: Race, Technology, And The Politics Of Preventive Medicine In The Early Twentieth Century, M. Allison Arwady

Yale Medicine Thesis Digital Library

Rickets, the bone disease classically caused by Vitamin D deficiency, was one of the most common diseases of children 100 years ago. It has been recognized as a disease of urban living and linked to issues of race and culture for generations. This paper uses unpublished patient records from 1904 to 1909 and archival and published materials from multiple community-based trials, including the New Haven Rickets Study (1923-1926), to explore how the definition, diagnosis, and treatment of rickets shifted in the first decades of the twentieth century in the United States. Before 1910, as evidenced by patient records, neither the …

Medicine@Yale March/April 2008 Volume 4, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Medicine@Yale September/October 2008 Volume 4, Issue 4, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Medicine@Yale July/August 2008 Volume 4, Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Medicine@Yale November/December 2008 Volume 4, Issue 5, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Serum S-100b As A Potential Biomarker For Meningitis In Febrile Infants: An Interim Analysis, Kelvin C. Lau

Yale Medicine Thesis Digital Library

The purpose of this study is to identify the utility of serum S-100B levels as a marker for meningitis in febrile infants younger than 3 months of age. All infants younger than 3 months of age who presented to the Pediatric Emergency Department (PED) of Yale-New Haven Children's Hospital and required both a lumbar puncture and venipuncture due to either a confirmed rectal temperature ≥38.0°C or an overall presentation that concerned the responsible physician for possible meningitis and required a lumbar puncture as part of their PED evaluation, were prospectively enrolled. A total of 111 patients participated after a 1.5-year …

Role Of Mkl1 In Megakaryocytopoiesis And In T(1;22)-Associated Acute Megakaryoblastic Leukemia, James Troy

Yale Medicine Thesis Digital Library

The t(1;22)(p13;q13) translocation creates a fusion of the genes RBM15 and MKL1 and is exclusively associated with the infantile form of Acute Megakaryoblastic Leukemia, or AML variant M7. Although MKL1 is a known coactivator of the Serum Response Factor (SRF) pathway, it is not known whether MKL1 plays an important role in megakaryocytic commitment or differentiation. This project investigated the role of MKL1 in normal megakaryocytopoiesis by using a human CD34+ hematopoietic stem cell (HSC) model. Human CD34+ HSCs were transduced with lentiviral vectors expressing either MKL1 or dominant negative MKL1 (DN-MKL1) and were cultured in conditions promoting megakaryocytopoiesis. After …

Bulletin Of Yale University School Of Nursing 2008-2009, Yale School Of Nursing

Yale School of Nursing Bulletins and Catalogues

Series 104, Number 14

September 5, 2008

Facts & Figures 2008 Yale School Of Medicine, Yale School Of Medicine Office Of Communications

Facts & Figures – annual Yale School of Medicine numbers

Provided by the Office of Communications, the Facts and Figures brochure is produced annually as a way to provide a snapshot of key facts and data related to the School of Medicine as well as the Medical Campus. This includes enrollment data, research activity, financial summaries, and more.

Measuring Turbulent Large-Eddy Structures With An Adcp. 1. Vertical Velocity Variance, A. E. Gargett, A. E. Tejada-Martínez, C. E. Grosch

Journal of Marine Research

Two different turbulent flows, Langmuir supercells and unstable convection, have been sampled with a VADCP, an acoustic Doppler current profiler (ADCP) with an additional vertical (V) beam. Direct measurements of the profile of vertical velocity variance provided by the vertical beam are used to calculate observational response functions for algorithms used to derive vertical velocity from the 4 beams of a standard ADCP. A theoretical response function derived for the vertical velocity estimate from a single pair of opposed slant beams illustrates the importance of large-scale quasi-coherent flow structures, as well as effects of different angles of slant beams from …

Ocean Color Data Assimilation With Material Conservation For Improving Model Estimates Of Air-Sea Co2 Flux, John C. P. Hemmings, Rosa M. Barciela, Michael J. Bell

Journal of Marine Research

A nitrogen balancing scheme for ocean color data assimilation in general circulation models is described and its potential for improving air-sea CO₂ flux estimates is demonstrated. Given increments for phytoplankton, obtainable from a univariate surface chlorophyll analysis, the scheme determines mixed layer concentration increments for the other nitrogen pools: zooplankton, detritus and dissolved inorganic nitrogen (DIN). The fraction of the phytoplankton increment to be balanced by changing DIN varies dynamically with the likely contributions of phytoplankton growth and loss errors to the error in the background state. Further increments are applied below the mixed layer wherever positive DIN increments …

The Impact Of Spatial Wind Variations On Freshwater Transport By The Alaska Coastal Current, John Rogers-Cotrone, Alexander E. Yankovsky, Thomas J. Weingartner

Journal of Marine Research

The Alaska Coastal Current (ACC) is located in a region with prevailing downwelling-favorable winds, flows over a long stretch of coastline (over 2000 km), and is driven by multiple sources of freshwater discharge totaling 24000 m³ s^–1 along its length. Using the Regional Ocean Modeling System (ROMS) we attempt to determine how spatially variable winds affect the downstream transport of freshwater along a long coastline with nearly continuous sources of freshwater. The model domain represents a fraction of the ACC region and periodic boundary conditions are applied to allow propagation of the buoyant flow from upstream. The model …

Observations Of Coastal Upwelling Off Uruguay Downshelf Of The Plata Estuary, South America, Felipe Pimenta, Richard W. Garvine, Andreas Münchow

Journal of Marine Research

We analyze hydrographic and current observations of an upwelling center off eastern South America on the Uruguayan coast (∼35S) and downshelf from the Rio de la Plata estuary. Our observations show that the buoyancy-driven subtidal alongshore circulation is modulated by winds. During the winter, strong upwelling-favorable local winds forced the Rio de la Plata buoyant plume poleward. In the summer, the plume detached from the coast with warm and saline subtropical waters intruding from the north. These waters bounded the upwelling of cold waters in the nearshore area off Uruguay. A shallow submarine canyon cutting obliquely across the shelf facilitates …

Toward A New Consciousness: Values To Sustain Human And Natural Communities, Anthony A. Leiserowitz, Lisa O. Fernandez

Yale School of the Environment Publications Series

A Synthesis of Insights and Recommendations from the 2007 Yale F&ES Conference

Medicine@Yale May/June 2008 Volume 4, Issue 2, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Beyond Patient Satisfaction: Physician Ambivalence, Authenticity, And The Challenges To Patient-Centered Medicine, Kiera S. Levine

Yale Medicine Thesis Digital Library

Despite tremendous and increasing clinical opportunities for cure and comfort, patients often still feel dissatisfied in their relationship with their doctor. That patient dissatisfaction has endured, even in the face of increasing medical knowledge and capacity, suggests a failing not in the quality of medical treatment but in the way it is administered. Increasingly, the modern medical movement toward patient-centered medical care (and away from doctor-centered care) has attempted to address this failing, looking to patient-satisfaction as one of its primary measures of success in these efforts. However, its willingness to overlook the importance of the basis of reported satisfaction, …

Seasonal Dynamics Of The Depth And Rate Of Anaerobic Oxidation Of Methane In Aarhus Bay (Denmark) Sediments, A. W. Dale, D. R. Aguilera, P. Regnier, H. Fossing, N. J. Knab, B. B. Jørgensen

Journal of Marine Research

A reactive-transport model has been applied to investigate the dynamics of the sulfate-methane transition zone (SMTZ) in nearshore sediments of Aarhus Bay (Denmark). The sediments are influenced by seasonal variations of temperature and particulate organic carbon (POC) deposition flux at the sediment-water interface. Initially, the model was calibrated at steady state using field data collected at two sites (M1 and M5) in December 2004, and included a dynamic gas phase which determines the depth of the SMTZ. Simulations were then performed under transient conditions of heat propagation in the porous medium, which influenced the solubility of gaseous methane, the diffusion …

Transport Of Blue Crab Larvae In The Middle Atlantic Bight: A Wet And Windy Journey, Charles E. Epifanio, Charles E. Tilburg

Journal of Marine Research

This paper describes the 25-year evolution of a program of research into the larval ecology of the Atlantic blue crab (Callinectes sapidus) near the mouth of Delaware Bay on the east coast of the USA (38.5N, 75.1W). The investigation began as a biological study; eventually incorporated a physical component; and finally added a mathematical modeling aspect. Early work was strictly biological and demonstrated that C. sapidus larvae are exported from the estuary to the adjacent coastal ocean where larval development occurs. Once this fact was established, it was clear that further progress demanded an understanding of shelf circulation. …

Yale Medicine : Alumni Bulletin Of The School Of Medicine, Autumn 2007- Spring 2008, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This volume contains Yale medicine: alumni bulletin of the School of Medicine, v.42 (Autumn 2007-Spring 2008). Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965).

Digitized with funding from the Arcadia fund, 2017.

Other Voices, Other Ways, Better Practices: Bridging Local And Professional Environmental Knowledge, Kim M. Wilkinson, Susan G. Clark, William R. Burch

Yale School of the Environment Publications Series

No abstract provided.

Health Economics For Low-Income Countries, Germano Mwabu

Discussion Papers

No abstract provided.

Memory T Cells And The Endothelium In Allograft Rejection, Stephen Lawrence Shiao

Yale Medicine Thesis Digital Library

Organ transplantation has become increasingly important as a treatment for many human diseases. Despite the dramatic improvements in immunosuppression in recent years, acute and chronic rejection remain significant problems. It has become increasingly evident that the presence of T cell memory correlates with both acute and chronic rejection episodes. Endothelial cells (EC) have been shown to preferentially activate memory T cells and, as the lining of every transplanted organ, they are in a unique position to provide signals to alloreactive memory T cells. EC activation of memory T cells depends in part on the costimulatory molecule LFA-3 in addition to …

From Barriers To Opportunities: Renewable Energy Issues In Law And Policy, Leslie Parker, Jennifer Ronk, Bradford Gentry, Martijn Wilder, James Cameron

Yale School of the Environment Publications Series

A Report on the Work of the Renewable Energy and International Law (REIL) Project, 2006-2007

Suppression Of Dgat2 Expression Improves Hepatic Steatosis And Prevents Fat Induced Insulin Resistance, Ameya Kulkarni

Yale Medicine Thesis Digital Library

It is well known that metabolites resulting from the accumulation of fat in tissue results in fatty liver, obesity, and insulin resistance. Because triglyceride synthesis is essential for this process, inhibition of the final step of TG synthesis has been considered as a new therapeutic target for hepatosteatosis and insulin resistance. In this study, we investigated the metabolic impact of acyl CoA: diacylglycerol acyltransferase 1 (DGAT1) and 2 (DGAT2) suppression. We used antisense oligonucleotides (ASOs) to reduce the expression of these enzymes in liver and fat in Sprague Dawley rats fed a 27% safflower oil high fat diet (HFD) for …

The Role Of Bone Marrow Derived Cells In A Model Of Hepatic Regeneration, Maria Mazzeo

Yale Medicine Thesis Digital Library

To examine the relationship between liver injury and the appearance of bone marrow derived hepatic cells we performed sex-mismatched bone marrow transplants in mice, with subsequent liver injury. Co-labeling for a marker of donor bone marrow origin and a marker of liver epithelial phenotype allowed us to identify rare marrow-derived hepatocytes at various time points following liver damage. The number of marrow-derived hepatocytes was low, however, and did not allow us to determine if liver-specific injury upregulated this process from baseline. We conclude that while marrow-derived hepatocytes are found, the low level of occurrence in this study makes it impossible …

Flow And Fates Of Discarded Copper In Sofia, Bulgaria, And New Haven Ct, Usa, Diana Dimitrova, Jason Rauch, Robert Gordon, T. E. Graedel

Yale School of the Environment Publications Series

In order to better understand the fate of copper following its use, the discard flows of copper were analyzed in Sofia, Bulgaria, and New Haven, CT, USA. These cities were chosen to compare discard copper generation and recovery between a city in a developed country and a city in a developing country. The comparison between these two cities can be problematic due to their different relative sizes, and generalizing the results to other cities cannot be done without some error. However, as the first study of its kind, this study provides insights into the relative copper recovery rates indifferent socioeconomic …

104 Publ L 208 Omnibus Consolidated Appropriations Act, 1997, U.S. Congress

Documents

No abstract provided.

The Effects Of Novel Serms On Endothelial And Epithelial Tumor Cell Estrogen Receptor Activation, Palvos Zacharias Kaimakliotis

Yale Medicine Thesis Digital Library

Premenopausal women are relatively protected against the development of coronary heart disease, when compared with age-matched men. This difference dissolves after menopause and is accepted to be hormonally mediated. Despite recent clinical controversies in the use of hormone replacement therapy in postmenopausal women, there have been numerous in vitro and in vivo studies that demonstrate favorable effects of estrogen on the endothelium. The Bender laboratory has shown that 17β-estradiol (E2) rapidly induces nitric oxide (NO) release from human endothelial cells (EC) in vitro. This occurs through a c-Src/phosphatidylinositol 3-kinase (PI3-kinase)/Akt pathway, in a rapid fashion in the absence of modulated …

Professional Ethics For Natural Resource And Environmental Managers: A Primer, Lloyd C. Irland

Yale School of the Environment Publications Series

No abstract provided.