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Motoneuron Excitability Dysfunction In Als: Pseudo-Mystery Or Authentic Conundrum?, Sherif M. Elbasiouny Oct 2022

Motoneuron Excitability Dysfunction In Als: Pseudo-Mystery Or Authentic Conundrum?, Sherif M. Elbasiouny

Neuroscience, Cell Biology & Physiology Faculty Publications

In amyotrophic lateral sclerosis (ALS), abnormalities in motoneuronal excitability are seen in early pathogenesis and throughout disease progression. Fully understanding motoneuron excitability dysfunction may lead to more effective treatments. Yet decades of research have not produced consensus on the nature, role or underlying mechanisms of motoneuron excitability dysfunction in ALS. For example, contrary to Ca excitotoxicity theory, predictions of motoneuronal hyper-excitability, normal and hypo-excitability have also been seen at various disease stages and in multiple ALS lines. Accordingly, motoneuron excitability dysfunction in ALS is a disputed topic in the field. Specifically, the form (hyper, hypo or unchanged) and what role …

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Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami Oct 2022

Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …

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Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami Oct 2022

Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …

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The Guardian The Week Of October 17, 2022, Wright State Student Body Oct 2022

The Guardian The Week Of October 17, 2022, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of October 17, 2022. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

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Safe Zones In Hip-Implant Designs To Resist Dislocation, Himanshu Bhatt, Tarun Goswami Oct 2022

Safe Zones In Hip-Implant Designs To Resist Dislocation, Himanshu Bhatt, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Major contributing parameters to hip implant dislocation include preoperative, intra-operative and post-operative factors. Implant geometry are design as well as non-design related. Femoral and acetabular component design features causing dislocation and/or resisting it are elucidated. Twelve implants were designed during this investigation were analyzed for dislocation resistance. A safe zone, establishes combinations of implant dimensions, was analyzed for all the 12 implants where implants were dislocation resistant. Head diameters between 26 mm to 32 mm, neck diameters closer to 14 mm, and neck angle between 25 to 35º were examined to be the safest ranges for hip implant designs.

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The Guardian The Week Of October 3, 2022, Wright State Student Body Oct 2022

The Guardian The Week Of October 3, 2022, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of October 3, 2022. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

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Secure Mimo Communication System With Frequency Hopping Aided Ofdm-Dcsk Modulation, Wenduo Qiu, Yimu Yang, Yan Feng, Lin Zhang, Zhiqiang Wu Oct 2022

Secure Mimo Communication System With Frequency Hopping Aided Ofdm-Dcsk Modulation, Wenduo Qiu, Yimu Yang, Yan Feng, Lin Zhang, Zhiqiang Wu

Electrical Engineering Faculty Publications

In this paper, a multiple-input multiple-output (MIMO) communication system with frequency hopping (FH) aided orthogonal frequency division multiplexing differential chaotic shift keying (OFDM-DCSK) modulation is proposed. Our objective is to improve the security of MIMO communication system which is encoded by space time block coding (STBC). In order to combat the eavesdropping or malicious attacks due to the broadcast characteristics of wireless communication system, we propose to use DCSK and FH modules to encrypt the information, and hide the user data in the chaotic sequences, where the initial value of chaotic sequences and the method of generating FH module are …

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Metal-To-Insulator Transition In An Anderson Insulator With Kondo Impurities, Weidong Zhang, Elliott R. Brown, Richard P. Mirin Oct 2022

Metal-To-Insulator Transition In An Anderson Insulator With Kondo Impurities, Weidong Zhang, Elliott R. Brown, Richard P. Mirin

Physics Faculty Publications

We report a voltage-controlled critical behavior observed in a GaAs epitaxial structure containing a dense array of ErAs nanoparticles. When fabricated with metal electrodes, the structure displays a voltage- and temperature-dependent metal-to-insulator transition and strong hysteresis in the current versus voltage and versus temperature characteristics, with critical temperatures as high as 77 K. Furthermore, we observed a diverging rms deviation of the electrical conductance with respect to the critical bias voltage, which further supports the existence of a phase transition. The insulating phase is governed by Efros-Shklovskii variable range hopping, and the conductance reduces beyond instrument limits as the temperature …

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Undergraduate And Graduate Course Descriptions, 2022 Fall, Wright State University Oct 2022

Undergraduate And Graduate Course Descriptions, 2022 Fall, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Fall 2022.

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The Extension Newsletter, Issue 110, Fall 2022, Wright State University Retirees Association Oct 2022

The Extension Newsletter, Issue 110, Fall 2022, Wright State University Retirees Association

The Extension Newsletter

An eight page newsletter from the Wright State University's Retirees Association.

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Isscm Newsletter, Fall 2022, Raj Soin College Of Business, Wright State University Oct 2022

Isscm Newsletter, Fall 2022, Raj Soin College Of Business, Wright State University

ISSCM Newsletters

An eight page newsletter from the Department of Information Systems and Supply Chain Management in the Raj Soin College of Business at Wright State University.

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Wright State University Magazine, Fall 2022, Wright State Alumni Association, Wright State Foundation Oct 2022

Wright State University Magazine, Fall 2022, Wright State Alumni Association, Wright State Foundation

Wright State University Magazine

52-page issue of the Wright State Magazine. This magazine is published twice a year and focuses on news related to Wright State alumni, faculty, and friends of the university.

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A Symmetric Matrix-Aided Mimo To Improve Reliability For Maritime Visible Light Communications, You Zhang, Yan Feng, Lin Zhang, Zhiqiang Wu Oct 2022

A Symmetric Matrix-Aided Mimo To Improve Reliability For Maritime Visible Light Communications, You Zhang, Yan Feng, Lin Zhang, Zhiqiang Wu

Electrical Engineering Faculty Publications

Turbulence in natural environments affects the reliability of communication. In this paper, we propose a symmetric matrix-assisted multiple-input multiple-output (MIMO) maritime visible light communication (VLC) system to confront turbulence and improve reliability. In our design, by exploiting the repeatability of elements in the symmetric matrix, the matrix can expand the Euclidean distance between signals and effectively restrains the interference between signals, thus improving the reliability of maritime VLC systems. In addition, we derive the theoretical symbol error rate (SER) of the proposed scheme. Then, simulation results are provided to validate the theoretical SER. In addition, the SER performances of the …

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The Specific Richness Of Forest Cockroach Communities In The Region Of Aflou (Laghouat; Algeria), Fatiha Masna, Siham Bounadji, Saliha Benhissen, Zakaria Hedjouli, Abdelmadjid Yagoub Asloum, Sarra Habbachi, Waffa Habbachi Sep 2022

The Specific Richness Of Forest Cockroach Communities In The Region Of Aflou (Laghouat; Algeria), Fatiha Masna, Siham Bounadji, Saliha Benhissen, Zakaria Hedjouli, Abdelmadjid Yagoub Asloum, Sarra Habbachi, Waffa Habbachi

Journal of Bioresource Management

Forest cockroaches are among the insects that play an important and effective role in forest formations, they are insects with incomplete metamorphosis belonging to the order of Blattodea. This work is a contribution to the knowledge of Blattoptera species existing in the forest environments of Aflou’s region (Laghouat; Algeria).The inventory was carried out monthly in the El-Khnegue Forest (Aflou) from February 2019 to May 2019. It revealed the presence of six species of forest Cockroaches, which belongs to 4 genera of the Blattelidae family. After identification, it was demonstrated that, these species were: Dziriblatta nigriventris (Chopard, 1936), Dziriblatta stenoptera (Chopard, …

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Importance And Winter Ornithological Value Of Lake El-Golea (Ghardaïa, Algerian Sahara, Biad Radhia, Bounab Choayb, Guergueb El Yamine, Biad Mohamed Fetheddine, Houhamdi Moussa Sep 2022

Importance And Winter Ornithological Value Of Lake El-Golea (Ghardaïa, Algerian Sahara, Biad Radhia, Bounab Choayb, Guergueb El Yamine, Biad Mohamed Fetheddine, Houhamdi Moussa

Journal of Bioresource Management

This study is carried out on two winter period (2018-2019 and 2019-2020) in Lake El-Golea (Ghardaïa, northern Sahara of Algeria). Its objective is to determine the ornithological value of this lake and to in ferits importance in maintaining aquatic avifauna during the winter season. This inventory shows a diversity equivalent to forty-one species belonging to thirteen families and nine orders of which eighteen are protected by various Algerian and international laws. The most represented family is that of the Anatidae with twelve species while the family with the highest number is that of the Phenicopteridae represented only by one species, …

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Health Safety In Drinks: Evaluation Of Certain Food Additives In Algeria, Saoussene Chernine, Samira Djekoun Bensoltane Sep 2022

Health Safety In Drinks: Evaluation Of Certain Food Additives In Algeria, Saoussene Chernine, Samira Djekoun Bensoltane

Journal of Bioresource Management

Consumption of drinks remains a controversial issue for public health. For more than 50 years, potential adverse reactions to additives have been suggested, but data to date are conflicting. The purpose of this article is to provide an approach to the health threat by inventorying the food additives used in 304 local and imported drinks sold in the Algerian market and classifying them according to their toxicity. In second time, survey population destinated to 1200 subjects to evaluate their drink consumption and health problems. The results show that the inventoried drinks contain many food additives, mostly consisting of dyes. Toxic …

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Toward Mental Effort Measurement Using Electrodermal Activity Features, William Romine, Noah Schroeder, Tanvi Banerjee, Josephine Graft Sep 2022

Toward Mental Effort Measurement Using Electrodermal Activity Features, William Romine, Noah Schroeder, Tanvi Banerjee, Josephine Graft

Computer Science and Engineering Faculty Publications

The ability to monitor mental effort during a task using a wearable sensor may improve productivity for both work and study. The use of the electrodermal activity (EDA) signal for tracking mental effort is an emerging area of research. Through analysis of over 92 h of data collected with the Empatica E4 on a single participant across 91 different activities, we report on the efficacy of using EDA features getting at signal intensity, signal dispersion, and peak intensity for prediction of the participant's self-reported mental effort. We implemented the logistic regression algorithm as an interpretable machine learning approach and found …

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The Guardian The Week Of September 18, 2022, Wright State Student Body Sep 2022

The Guardian The Week Of September 18, 2022, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of September 18, 2022. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

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Board Of Trustees Meeting Minutes, September 16, 2022 Sep 2022

Board Of Trustees Meeting Minutes, September 16, 2022

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on September 16, 2022.

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The Guardian The Week Of September 11, 2022, Wright State Student Body Sep 2022

The Guardian The Week Of September 11, 2022, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of September 11, 2022. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

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Leveraging Natural Learning Processing To Uncover Themes In Clinical Notes Of Patients Admitted For Heart Failure, Ankita Agarwal, Krishnaprasad Thirunarayan, William Romine, Amanuel Alambo, Mia Cajita, Tanvi Banerjee Sep 2022

Leveraging Natural Learning Processing To Uncover Themes In Clinical Notes Of Patients Admitted For Heart Failure, Ankita Agarwal, Krishnaprasad Thirunarayan, William Romine, Amanuel Alambo, Mia Cajita, Tanvi Banerjee

Computer Science and Engineering Faculty Publications

Heart failure occurs when the heart is not able to pump blood and oxygen to support other organs in the body as it should. Treatments include medications and sometimes hospitalization. Patients with heart failure can have both cardiovascular as well as non-cardiovascular comorbidities. Clinical notes of patients with heart failure can be analyzed to gain insight into the topics discussed in these notes and the major comorbidities in these patients. In this regard, we apply machine learning techniques, such as topic modeling, to identify the major themes found in the clinical notes specific to the procedures performed on 1,200 patients …

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Non-Invasive Transcutaneous Spinal Dc Stimulation As A Neurorehabilitation Als Therapy In Awake G93a Mice: The First Step To Clinical Translation, Morgan M. Highlander, Sherif M. Elbasiouny Sep 2022

Non-Invasive Transcutaneous Spinal Dc Stimulation As A Neurorehabilitation Als Therapy In Awake G93a Mice: The First Step To Clinical Translation, Morgan M. Highlander, Sherif M. Elbasiouny

Neuroscience, Cell Biology & Physiology Faculty Publications

Spinal direct current stimulation (sDCS) modulates motoneuron (MN) excitability beyond the stimulation period, making it a potential neurorehabilitation therapy for amyotrophic lateral sclerosis (ALS), a MN degenerative disease in which MN excitability dysfunction plays a critical and complex role. Recent evidence confirms induced changes in MN excitability via measured MN electrophysiological properties in the SOD1 ALS mouse during and following invasive subcutaneous sDCS (ssDCS). The first aim of our pilot study was to determine the clinical potential of these excitability changes at symptom onset (P90-P105) in ALS via a novel non-invasive transcutaneous sDCS (tsDCS) treatment paradigm on un-anesthetized SOD1-G93A mice. …

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Developing Scaling Laws To Predict Compressive Mechanical Properties And Determine Geometrical Parameters Of Modified Bcc Lattice Structures, Hasanain Abdulhadi, Abdalsalam Fadeel, Tahseen A. Alwattar, Ahsan Mian Sep 2022

Developing Scaling Laws To Predict Compressive Mechanical Properties And Determine Geometrical Parameters Of Modified Bcc Lattice Structures, Hasanain Abdulhadi, Abdalsalam Fadeel, Tahseen A. Alwattar, Ahsan Mian

Mechanical and Materials Engineering Faculty Publications

The objective of this study is to develop generalized empirical closed-form equations to predict the compressive mechanical properties and determine geometrical parameters. To achieve that, 117 models are built and analyzed using ABAQUS/CAE 2016 to provide two types of reliable data: one for lattice mechanical properties based on finite element method and the other for geometrical parameters using the measurements of ABAQUS diagnostic tool. All the models are created by modifying the basic feature of body-centered cubic lattice structure based on a range of strut angles, a set of relative densities, and two design sets. Also, the influence of lattice …

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Gerald Alter, Professor Emeritus, Biochemistry And Molecular Biology, Gerald Alter, Kathy Morris Aug 2022

Gerald Alter, Professor Emeritus, Biochemistry And Molecular Biology, Gerald Alter, Kathy Morris

Wright State University Retirees Association Oral History Project

In this August 25, 2022 oral history interview conducted by Kathy Morris, Dr. Gerald Alter discusses his career in biochemistry and his contributions to the development of Wright State University’s Biomedical Sciences Ph.D. program. He reflects on interdisciplinary research, graduate education, institutional support for scholarship, and his leadership during a period of heightened oversight of the Laboratory Animal Care and Use Committee.

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Drone-Based Water Sampling And Characterization Of Three Freshwater Harmful Algal Blooms In The United States, Regina Hanlon, Stephen J. Jacquemin, Johnna A. Birbeck, Judy A. Westrick, Charbel Harb, Hope Gruszewski, Andrew P. Ault, Durelle Scott, Hosein Foroutan, Shane D. Ross, Javier González-Rocha, Craig Powers, Lowell Pratt, Harry Looney, Greg Baker, David G. Schmale Aug 2022

Drone-Based Water Sampling And Characterization Of Three Freshwater Harmful Algal Blooms In The United States, Regina Hanlon, Stephen J. Jacquemin, Johnna A. Birbeck, Judy A. Westrick, Charbel Harb, Hope Gruszewski, Andrew P. Ault, Durelle Scott, Hosein Foroutan, Shane D. Ross, Javier González-Rocha, Craig Powers, Lowell Pratt, Harry Looney, Greg Baker, David G. Schmale

Biological Sciences Faculty Publications

Freshwater harmful algal blooms (HABs), caused mostly by toxic cyanobacteria, produce a range of cyanotoxins that threaten the health of humans and domestic animals. Climate conditions and anthropogenic influences such as agricultural run-off can alter the onset and intensity of HABs. Little is known about the distribution and spread of freshwater HABs. Current sampling protocols in some lakes involve teams of researchers that collect samples by hand from a boat and/or from the shoreline. Water samples can be collected from the surface, from discrete-depth collections, and/or from depth-integrated intervals. These collections are often restricted to certain months of the year, …

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Probabilistic Risk Assessment For Life Extension Of Turbine Engine Rotors, Jace A. Carter, Tarun Goswami Jul 2022

Probabilistic Risk Assessment For Life Extension Of Turbine Engine Rotors, Jace A. Carter, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Maintaining the component service life beyond its historical limits requires the ability to accurately quantify component reliability and address the uncertainties in material responses. A probabilistic method for predicting the total fatigue life was developed and applied to determine the probability of failure of a Ti-6Al-4V turbine disk component. The total fatigue life incorporates a dual mechanism approach including the crack initiation life and propagation life while simultaneously determining the associated initial flaw sizes. A microstructure-based model was employed to address the uncertainties in material response and relate the crack initiation life with crack size. The propagation life was characterized …

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Validation Of Experimental And Finite Element Biomechanical Evaluation Of Human Cadaveric Mandibles, Shirish M. Ingawale, Deepak G. Krishnan, Tarun Goswami Jul 2022

Validation Of Experimental And Finite Element Biomechanical Evaluation Of Human Cadaveric Mandibles, Shirish M. Ingawale, Deepak G. Krishnan, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Background: Biomechanical analysis of human mandible is important not only to understand mechanical behavior and structural properties, but also to diagnose and develop treatment options for mandibular disorders. Therefore, the objective of this research was to generate analytical and experimental data on mandibles, construct custom 3D models, and compare the analytically derived maximum strains with strain gage data in five areas of interest for each mandible. Methods: We investigated the surface strains in the cadaveric human mandibles under different configurations of cyclic compressive loads in an experimental setting and compared these experimental strain data with results derived from computational finite …

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Characterization Of In Vivo Damage On Retrieved Total Shoulder Glenoid Liners, Eric Cheatwood, Gerard Simon, Lynn Crosby, Tarun Goswami Jul 2022

Characterization Of In Vivo Damage On Retrieved Total Shoulder Glenoid Liners, Eric Cheatwood, Gerard Simon, Lynn Crosby, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

An attempt was made to retrieve glenoid liners from revision surgery to undertake a retrospective study to measure the resulting in vivo damage. Since the glenoid liners are circumferential, the curvature changes at every point in the component, an “assisting arm” was designed to hold the liner firmly, thus allowing accurate microscopic measurements. We characterized the damage in terms of pitting, embedded debris, complete fracture, abrasion, deformation, delamination, burnishing, grooving, and scratching that took place mutually exclusively. This study of 26 liners showed embedded debris was the most underrated damage mode found on the liners, followed by pitting and abrasion, …

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Etiology Of Breast Development And Asymmetry, Elisabeth N. Adkins, Shaina Anderson, Trevor Mckoy, Nakachi Maduka, Tarun Goswami Jul 2022

Etiology Of Breast Development And Asymmetry, Elisabeth N. Adkins, Shaina Anderson, Trevor Mckoy, Nakachi Maduka, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Etiology of breast development and asymmetry is a fascinating research topic physiologically as well as pathophysiology from a certain condition. The shape, contour, and size of the breast are unique to each female. These factors are influenced by genetics, weight, exercise, menstruation cycles, pregnancy, menopause status, and age. An attempt was made to research the breast development at fetal development and transitioning into adulthood and menopause. Additionally, we compare breast development in males to the developments in females. Although breast asymmetry is experienced by all women, it ranges from grossly undetectable to the need for surgical intervention. It is thought …

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Improving The Factual Accuracy Of Abstractive Clinical Text Summarization Using Multi-Objective Optimization, Amanuel Alambo, Tanvi Banerjee, Krishnaprasad Thirunarayan, Mia Cajita Jul 2022

Improving The Factual Accuracy Of Abstractive Clinical Text Summarization Using Multi-Objective Optimization, Amanuel Alambo, Tanvi Banerjee, Krishnaprasad Thirunarayan, Mia Cajita

Computer Science and Engineering Faculty Publications

While there has been recent progress in abstractive summarization as applied to different domains including news articles, scientific articles, and blog posts, the application of these techniques to clinical text summarization has been limited. This is primarily due to the lack of large-scale training data and the messy/unstructured nature of clinical notes as opposed to other domains where massive training data come in structured or semi -structured form. Further, one of the least explored and critical components of clinical text summarization is factual accuracy of clinical summaries. This is specifically crucial in the healthcare domain, cardiology in particular, where an …

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