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A Review On Psychosocial Distress Among General Population Of Pakistan During Covid-19 Pandemic, Anosh Arshad Chaudhary, Iqra Arooj, Amina Elahi

Journal of Bioresource Management

The COVID-19 crisis in 2019 significantly impacted human life all over the globe. Psychological health of general population has been affected by the unpredictable circumstances and impulsion of living in isolation, if suspected positive for coronavirus. During COVID-19 outbreak, escalation of various types of psychosocial distresses such as anxiety, sleep disorders and depression has been observed in the general population globally. Thus, there is an urgent need to combat these issues through well planned strategies. The focus of this review is to conduct a thorough evaluation of the available research on the effects of COVID-19 pandemic on the mental status …

Nanoparticulate Carriers For Drug Delivery, Samantha Lokelani Crossen, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Drug delivery with nanoparticulate carriers is a new and upcoming research area that is making major changes within the pharmaceutical industry. Nanoparticulate carriers are discussed, particularly, engineered nanoparticulate carriers used as drug delivery systems for targeted delivery. Nanoparticulate carriers that are used for drug delivery systems include polymers, micelles, dendrimers, liposomes, ceramics, metals, and various forms of biological materials. The properties of these nanoparticulate carriers are very advantageous for targeted drug delivery and result in efficient drug accumulation at the targeted area of interest, reduced drug toxicity, reduced systemic side effects, and more efficient use of the drug overall. Nanoparticlulate …

First Annual Research Symposium Program With Abstracts, Office Of Research Affairs, Boonshoft School Of Medicine

Boonshoft School of Medicine Research Symposium

The program booklet is a compilation of abstracts from oral and poster presentations at Wright State University's First Annual Boonshoft School of Medicine Medical Research Symposium held on April 6, 2022.

Fungal Burden Of Disease In Central And South America, Urmimala Chaudhuri

Master of Public Health Program Student Publications

Background: Serious fungal infections are associated with an increase in mortality. Globally, fungal infections affect high-risk groups such as individuals with HIV/AIDS, asthma, transplant recipients, and those on immunosuppression. The most common fungal diseases include Histoplasmosis, Pneumocystis pneumonia (PCP), Candidiasis, and Allergic bronchopulmonary aspergillosis (ABPA). Epidemiological information on the prevalence of fungal diseases has been limited, particularly in Central and South America due to inadequate surveillance. Purpose: The aim of this review was to evaluate the burden of common fungal diseases in Central and South America and discuss strategies of national surveillance. Methods: PubMed searches were conducted from the years …

Current Epidemiological Status And Antibiotic Resistance Profile Of Urinary Tract Infection, Muddasir Khan, Syed Hussain Shah, M. Abdullah, Muhammad Salman, Fawad Hayat, Raheela Sarwar, Neelma Hassan, Sohail Ahmad Jan, M. Saddam, Ziaur Rahman, Imran Qazi

Journal of Bioresource Management

With a longitudinal (2020–2021) completion, a set of 300 urine samples of individuals suspected of UTI was characterized based on the biochemical analysis and Kirby Bauer's disc diffusion method. Throughout, a total of 167 samples revealed UTI positivity by obtaining bacterial growth. Reporting that E. coli (69.4 %) was the most dominant when compared with Klebsiella (14.3 %), Proteus (5.9 %), S. aureus (4.7 %), P. aeruginosa (3.5 %), and Enterobacter (1.7 %), respectively. Gender-wise discrimination showed that E. coli was highly distributed among female (50.2 %) patients. A prominent percentage of E. coli (41.9 %) was found in the …

A Review On Empirical Approach To Therapeutic Recombinant Protein Production Factories: Applications, Pharmacokinetics And Challenges, Zahra Naz, Ambreen Kanwal, Asima Tayyeb

Journal of Bioresource Management

Major portion of the proteins in a cell refers to their critical roles in metabolism of the living body. Proteins dysfunction results in the severe disorders which need to be treated in time. For this, respective proteins can be extracted by the external sources and be supplied to the human beings. Such medicinal proteins are known as therapeutic proteins (TPs). This review summarizes some of the key areas about these miracle proteins like their types, classification, production factories, routes of administration, pharmacokinetics, and potential applications. Furthermore, challenges and hurdles faced in getting a potential protein drug, its FDA approval and …

Robert Brandt Interview For The Boonshoft School Of Medicine 50th Anniversary Oral History Project, Robert Brandt, Kristen Dilger

Boonshoft 50th Anniversary Oral History Project

Kristen Dilger interviews Robert Brandt, a graduate of the Boonshoft School of Medicine. He worked in Family Medicine as both a primary care physical and HIV/AIDS specialist, along with his role as a clinical professor for the Boonshoft School of Medicine until his retirement in 2018. Part of the class of 1980, Brandt discusses his collegiate career, including why he chose Wright State University's new medical college and talks about what it was like attending the college. He talks about the challenges and processes of attending a new medical college, and how attending the Wright State University Boonshoft School of …

Mosquito Survey In Tizi-Ouzou (Algeria Northern): Updated Inventory With New Reports, Soumeya Chahed, Hania Belkacem, Lynda Boukhari, Karima Brahmi

Journal of Bioresource Management

Mosquitoes play an important role in public health, they are responsible for the transmission of pathogens that cause infectious diseases to both humans and animals. The study of this fauna biodiversity is necessary to determine the vector species of diseases. Our inventory of mosquitoes in Tizi-Ouzou province has been updated in this study, it was carried out from April to September, 2021 at 43 breeding sites, spread over ten different communes. The inventory was based on the sampling of larvae and the capture of adults on human bait. The identification of Culicidae inventoried revealed the presence of 14 species belonging …

Whistling Scrotum: An Unusual Presentation Of Pneumomediastinum In The Setting Of An Open Scrotal Wound, Brant Bickford, Andrew J. Berglund, Ronald J. Markert, Hari Polenakovik

Internal Medicine Faculty Publications

BACKGROUND Pneumoscrotum is a rare clinical occurrence in which air accumulates in the scrotum. The origin of air is primarily from trauma, but spontaneous pneumoscrotum can develop from gastrointestinal or pulmonary sources. Physical examination of pneumoscrotum typically includes crepitus of the perineal region and scrotal swelling and associated findings depending on the origin of the free air. However, pneumoscrotum in the setting of a scrotal wound, which allows air to pass freely outside the body, has not been previously documented in the literature. CASE REPORT A 72-year-old man who recently underwent a scrotal incision and drainage for recurrent epididymitis presented …

Evaluating Energy-Based Trait Shifts And Population Level Impacts Of Big Brown Bats (Eptesicus Fuscus) With Long-Term Exposure To Pseudogymnoascus Destructans, Molly C. Simonis

Browse all Theses and Dissertations

Disturbances in environment can lead to a wide range of host physiological responses. These responses can either allow hosts to adjust to new conditions in their environment or can reduce their survival, and can subsequently cause host traits to shift. Small mammals are particularly vulnerable to stochastic disturbances, like a pathogen introduction, because of their high energy demands. Studies examining host responses to pathogens often focus on species highly susceptible to infection that typically have high mortality rates, leading to a gap in understanding the responses of less susceptible species. My dissertation evaluates the energy balance of Eptesicus fuscus (big …

Molecular Dynamics Simulation Study Of A Polymer Droplet Transport Over An Array Of Spherical Nanoparticles, Anish Thomas

Browse all Theses and Dissertations

This study uses molecular dynamics simulations to evaluate the dynamic behavior of a partially wetting polymer droplet driven over a nanostructured interface. We consider the bead-spring model to represent a polymeric liquid that partially wets a rough surface composed of a periodic array of spherical particles. Results show that at sufficiently small values of external force, the droplet remains pinned at the particle's surface, whereas above the threshold its motion consists of alternating periods of pinning and rapid displacements between neighboring particles. The latter process involves large periodic variation of the advancing and receding contact angles due to the attachment …

The Impact Of Sentiment And Misinformation Cycling Through The Social Media Platform, Twitter, During The Initial Phase Of The Covid-19 Vaccine Rollout, Emily Grace Burwell

Browse all Theses and Dissertations

This study assesses the underlying topics, sentiment, and types of information regarding COVID-19 vaccines on Twitter during the initiation of the vaccine rollout. Tweets about the COVID-19 vaccine were collected and the relevant tweets were then filtered out using a relevancy classifier. Latent Dirichlet Allocation (LDA) was used to uncover topics of discussion within the relevant tweets. The NRC lexicon was used to assess positive and negative sentiment within tweets. The type of information (information, misinformation, opinion, or question) in tweets was evaluated. The relevancy classifier resulted in a dataset of 210,657 relevant tweets. Eight topics provided the best representation …

Ifn-Γ Increases The Expression Of Sars-Cov-2 Receptors On Vero E6 Cells, Bindu Madhavi Madabattula

Browse all Theses and Dissertations

Respiratory epithelial cells are the initial target for SARS-CoV-2 infection. IFN-γ is known to increase the expression of ACE-2, an initial receptor for SARS-CoV-2, on epithelial cells. This study focuses on examining the effect of IFN-γ for ACE-2, TMPRSS2, and neuropilin-1 on Vero E6 cells using two immunofluorescence methods, namely, direct (membrane) fluorescence method and Cytation5 method. Direct fluorescence was determined using an Accu-Scope and ImageJ analysis. Using this method, significance (p<0.023) was observed only for ACE-2 when Vero E6 cells were treated with IFN-γ. Cytation5 fluorescence was determined using a Bio-tek Cytation5 plate reader. The results showed that IFN-γ significantly increased (p<0.001) the expression of ACE-2, neuropilin-1, and TMPRSS2. These results indicate Cytation5 is a more sensitive method for determining the expression of receptors on Vero E6 cells. The elevated levels of SARS-CoV-2 receptors expression resulting from IFN-γ treatment makes the epithelial cells more susceptible targets of SARS-CoV-2 infection. IFN-γ is most likely provided by innate immune cells in the initial COVID-19 infection, consequently contributing to the severity of disease.

Expression Of Sars Cov2 Receptors Influenced Upon Cytokine Polarizations (Il-4 And Ifnγ) In Hemangioendothelioma Cells, Chandra Lekha Koopari

Browse all Theses and Dissertations

Endothelial cells are distinct multifunctional cells with essential metabolic and synthetic roles along with their ability to function as selective permeability barrier. Endothelial cells (ECs), the major component of blood vessels, essentially interact directly yet differently with inflammatory cytokines. ECs are well recognized to be polarized cells, but little is known about the potential function of inflammatory mediators. Covid 19 may have long-term health effects on par with chronic illnesses. Vascular inflammatory disease and coagulopathy linked to COVID-19 are exacerbated by endothelial cell (EC) dysfunction. SARS-CoV-2 enters the host cell through the Angiotensin Converting Enzyme 2 (ACE2) receptor and primes …

A Review Of Globally Important Plant Origin Antioxidants And Their Folk Utility For Various Diseases, Nosheen Akhtar, Ali Nasir, Hanachi Paricheher

Journal of Bioresource Management

This review article has attempted to analyze the folk utility of important medicinal plants having valuable secondary metabolites used for the treatment of a variety of diseases. It is estimated that two-thirds of the total medicinal plants are used for the treatment of various diseases. Some medicinal plants are known for great antioxidant properties. Antioxidants reduce oxidative stress in cells. Antioxidants are useful for the treatment of cardiovascular diseases, inflammatory diseases, and cancers. This review article discloses the naturally occurring antioxidants and their sources. Medicinal plants with such a high potential of antioxidants have been part of folk medicine over …

Prevalence And Multidrug Resistance Pattern Of E. Coli Among Urinary Tract Infection Patients In Tertiary Care Hospital Of Multan, Hubza Ruatt Khan, Mehvish Javeed, Asghar Javed, Nisma Farooq

Journal of Bioresource Management

Urinary Tract Infection is alarming problem worldwide due to the intensity of antimicrobial resistance. Escherichia coli is the most predominant organism in UTI. This study was planned to evaluate demographic parameters, the prevalence of E. coli, and antimicrobial resistance patterns among E. coli isolates from UTI patients in Nishtar Hospital of Multan from January to June 2018. A total of 350 mid-stream urine samples were collected from different patients having age group from 25 to 60 years and processed by standard laboratory procedures. Out of 350 samples, 100 samples were observed as critical bacteremia. Escherichia coli and Klebsiella …

Nsaids Naproxen, Ibuprofen, Salicylate, And Aspirin Inhibit Trpm7 Channels By Cytosolic Acidification, Rikki Chokshi, Orville Bennett, Tetyana Zhelay, J. Ashot Kozak

Neuroscience, Cell Biology & Physiology Faculty Publications

Non-steroidal anti-inflammatory drugs (NSAIDs) are used for relieving pain and inflammation accompanying numerous disease states. The primary therapeutic mechanism of these widely used drugs is the inhibition of cyclooxygenase 1 and 2 (COX1, 2) enzymes that catalyze the conversion of arachidonic acid into prostaglandins. At higher doses, NSAIDs are used for prevention of certain types of cancer and as experimental treatments for Alzheimer’s disease. In the immune system, various NSAIDs have been reported to influence neutrophil function and lymphocyte proliferation, and affect ion channels and cellular calcium homeostasis. Transient receptor potential melastatin 7 (TRPM7) cation channels are highly expressed in …

A Review Of Novel Coronavirus: Cross-Disciplinal Perspective, Iram Asim, Hafsa Rehman, Rabeea Anwar, Humaira Yasmeen

Journal of Bioresource Management

The whole world is under the influence of coronavirus after its first report from Wuhan, China in December 2019. The virus is from coronaviridae family which has zoonotic viruses that can spread from animals to humans. The coronavirus like other viruses of this family produces mild flu-like symptoms within 2-14 days in the human host which progresses to death in severe cases. Unlikely coronavirus spread fast among humans-infectious diseases. Up till now (27/04/2020) around 2.97M cases and 207K deaths have been reported. The presence of a virus in respiratory secretions is diagnosed through molecular methods and chest scans. For this …

A Multi-Stage Seir(D) Model Of The Covid-19 Epidemic In Korea, Hee-Young Shin

Economics Faculty Publications

Background: This paper uses a SEIR(D) model to analyse the time-varying transmission dynamics of the COVID-19 epidemic in Korea throughout its multiple stages of development. This multi-stage estimation of the model parameters offers a better model fit compared to the whole period analysis and shows how the COVID-19's infection patterns change over time, primarily depending on the effectiveness of the public health authority's non-pharmaceutical interventions (NPIs). Methods: This paper uses the SEIR(D) compartment model to simulate and estimate the parameters for three distinctive stages of the COVID-19 epidemic in Korea, using a manually compiled COVID-19 epidemic dataset for the period …

Psychological Impact Of Novel Coronavirus Covid-19 Across The Globe-A Review, Sadaf Shaheen, Iram Asim, Rida Zainab, Humaira Yasmeen

Journal of Bioresource Management

The recent outbreaks of novel coronavirus disease have unprecedent impact on mental health of patients, front-line healthcare workers and local population. However, the impact is not fully documented. This review explores stress-driven factors, stress-vulnerable groups and stress management interventions. Repetitive exposure to mass media and inappropriate health protective measures has heightened stress responses. Fear of not getting recovered from COVID-19 and disaffection has profound impact of infected individuals and their families. They may experience fear, anxiety, anger, sleep deprives and anorexia which may weakens their immune system thus making them vulnerable to COVID-19. The COVID-19 pandemic has underscored potential gaps …

Challenges And Opportunities In Food Safety-A Review, Iram Asim, Humaira Yasmeen

Journal of Bioresource Management

Food-borne diseases are the group of disorders that are caused by consuming food having microbial existence in it. So safe food handling is to make sure the lessening of detrimental effects in growth to the packaging of food to minimize health issues on consumers which otherwise can lead to large scale disease outburst. This review concludes the findings of the studies on how food is being handled from farm to fork, how airlines are contributing towards the spreading of diseases, how any negligence in any one of the steps can cause havoc to mankind in the light of the recent …

Phytochemical Screening, Antimicrobial Activity Of Gemmotherapeutically White Mulberry (Morus Alba) Leaves, Abu Ul Hassan Faiz, Lariab Zahara Faiz

Journal of Bioresource Management

The present study was designed to find out phytochemical analysis and antimicrobial activity of leaves of Mulberry plant. The phytochemical analysis was performed on quantitative and qualitative basis. The qualitative basis indicated the presence of alkaloids, glycosides, flavonoids, steroids, tannins, saponins and Anthraquinone. The quantitative analysis showed alkaloids (40%), glycosides (20.05%), flavonoids (14%), steroids (3.5%), tannins (11.9%) and saponins (11.5%) and anthraquinone (0.5%) presence. Antimicrobial activity against bacteria has been observed in the leaves of Mulberry (Morus alba) and showed zone of inhibition, Escherichia coli (7±3.3) mm, Staphylococcus aurous (8±3.1), Bacillus subtilis (9±2.5), Pasturella multocida (8±3.1) mm.

Dosing Recommendations For Vancomycin In Children And Adolescents With Varying Levels Of Obesity And Renal Dysfunction: A Population Pharmacokinetic Study In 1892 Children Aged 1–18 Years, Cornelis Smit, Sebastiaan C. Goulooze, Roger J. M. Brüggemann, Catherine M. Sherwin, Catherijne A. J. Knibbe

Pediatrics Faculty Publications

Vancomycin is an effective but potentially nephrotoxic antibiotic commonly used for severe infections. Dosing guidelines for vancomycin in obese children and adolescents with or without renal impairment are currently lacking. This study describes the pharmacokinetics of vancomycin in a large pediatric cohort with varying degrees of obesity and renal function to design practical dosing guidelines for this population. A multi-center retrospective population pharmacokinetic study was conducted using data from patients aged 1−18 years who received >1 dose of vancomycin and had ≥1 vancomycin concentration measured between January 2006 and December 2012. Besides pharmacokinetic data, age, gender, body weight, creatinine clearance …

Leveraging Natural Language Processing To Mine Issues On Twitter During The Covid-19 Pandemic, Ankita Agarwal, Preetham Salehundam, Swati Padhee, William Romine, Tanvi Wright State University - Main Campus

Computer Science and Engineering Faculty Publications

The recent global outbreak of the coronavirus disease (COVID-19) has spread to all corners of the globe. The international travel ban, panic buying, and the need for self-quarantine are among the many other social challenges brought about in this new era. Twitter platforms have been used in various public health studies to identify public opinion about an event at the local and global scale. To understand the public concerns and responses to the pandemic, a system that can leverage machine learning techniques to filter out irrelevant tweets and identify the important topics of discussion on social media platforms like Twitter …

Traffic Related Air Pollution Exposure Effect On Circulating White Blood Cell Counts In Healthy Individuals, Anjam Shezadi, Muhammad Shahbaz, Irfan Baboo, Faiza Shakir, Misbah Shoukat, Maryam Anwar, Badra Younis, Rabia Akbar, Amna Benish, Lubna Mumtaz, Zahid Farooq

Journal of Bioresource Management

During this short term study a total of 110 samples were collected from the selected individuals of study area. This study was aimed to count the White blood cells in the blood samples of individuals, who were mostly exposed to exhaust fumes (air pollution), like traffic constables, cooks and shopkeepers. For this purpose blood samples were taken into an evacuee container having anticoagulant Ethylene diamine tetra-acetic acid (EDTA) so to prevent coagulation of blood, for the count of WBCs, heamocyto-meter was used. During the study the body mass index and blood pressure was also measured by digital blood pressure measuring …

Antimicrobial Use In Positive Respiratory Viral Panel: Impact Of Procalcitonin Use And Antimicrobial Stewardship, David Beleny

Scholarship in Medicine - All Papers

increasing antibiotic resistant microbes.¹ Blood and sputum cultures are the gold standard for bacterial identification, but they are difficult to obtain and take days to receive back from the lab. Physicians commonly treat patients empirically with antibiotics because there is an increased risk of 30-day mortality in patients with bacterial community-acquired pneumonia (CAP).² Overuse of antibiotics is commonplace in hospitalized patients which is detrimental as it contributes to antibiotic resistance, costs money, wastes resources, and puts patients at risk for unnecessary adverse effects of the medications.³ It was found that 75% of patients presenting with a respiratory …

Human Immunodeficiency Virus (Hiv) – An Analysis Of Trends In Hiv Diagnoses From 2008 – 2018, Ulysses G. Gardner

Scholarship in Medicine - All Papers

Objective: An estimated 1.1 million people are living with the human immunodeficiency virus (HIV) in the United States. Despite over two decades of research, a cure for HIV has not been approved and it remains a pandemic. This research study was conducted to determine the statistical significance in HIV incidence based on diagnoses in 2008 versus 2018; age groups 25-34 years old versus 55+ years old; Black versus Hispanic versus White; male versus female; and geographical location. Methods: This retrospective study was conducted using data from the Center for Disease Control and Prevention (CDC) Atlas Plus data sets, a collection …

In The Shadow Of Freedom Of Religion And Press, Hee-Young Shin

Economics Faculty Publications

The Korean government’s public health responses to the COVID-19 epidemic have achieveda remarkable outcome in terms of the measured number of infected patients and theoverall mortality rate. Nonetheless, the public health authority’s various mitigationstrategies and vaccination efforts have faced several challenges primarily posed bypolitically motivated Christian fundamentalists and ultraconservative media’s distortednews framing in Korea. This paper examines how these conservative forces – both religiousand political – have undermined the Korean public health authority’s various mitigationefforts and discusses how to address the problems from a public policy point of view. Thepaper argues that a comprehensive legal reform including the introduction of …

Vital Signs, Winter 2021, Boonshoft School Of Medicine

Vital Signs

A newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Non-Communicable Diseases And Social Media: A Heart Disease Symptoms Application, Ashwin Kumar Thandapani Kumarasamy, Daniel Asamoah, Ramesh Sharda

Management Information Systems Faculty Publications

Social media platforms have become ubiquitous and allow users to share information in real-time. Our study uses data analytics as an approach to explore non-communicable diseases on social media platforms and to identify trends and patterns of related disease symptoms. Exploring epidemiological patterns of non-communicable diseases is vital given that they have become prevalent in low income communities, accounting for about 38 million deaths worldwide.

We collected data related to multiple disease conditions from the Twitter microblogging platform and zoomed into symptoms related to heart diseases. As part of our analyses, we focused on the mechanism and trends of disease …