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Refugee Health In Montgomery County: A Retrospective Descriptive Study Of Refugee Health Screening Results From April 2007 - April 2008, Marjan Lyons

Master of Public Health Program Student Publications

Introduction: The top refugee health concerns characteristically are associated with parasitic infections, infectious diseases such as malaria, tuberculosis, and parasites, as well as nutritional deficiencies such as anemia, and malnourishment. Understanding the specific health needs of the refugee population will not only improve the transition of the refugees within the United States healthcare systems, but also improve public health within the community.

Methods: Health records from Public Health - Dayton & Montgomery Country were used to obtain the prevalence of both acute and chronic health conditions within the newly resettled refugee population. There were a total of 193 refugees included …

The 24th Annual Research Conference Abstract Booklet, Nikki Lynn Rogers

University of Gondar Research Conferences

Staff members, postgraduate and senior undergraduate students of the University, invited guests and speakers participated in the conference. The annual conference of the University is meant to share experiences in research activities among juniors and seniors, staff and students, and invited guests. It is also meant to motivate students and young faculty to engage in research and also to initiate and strengthen interdisciplinary collaborations. The findings of the studies and the resulting recommendations are expected to be used in solving the diverse societal problems we have been facing.

Research activities at the University of Gondar are primarily aimed at solving …

From Sea To Shining Sea: Force Health Management Of Infectious Diseases In A Cross-Global Deployment Flux Toward Tropical Environments, Joanna M. Nelms

Master of Public Health Program Student Publications

Infectious diseases in fighting armies are a pestilence as old as war itself. The history of the United States military is rich in successes of innovation and lessons learned in failure in the prevention and treatment of infectious diseases. Over the nearly two and a half centuries of American warfare, military research and development have contributed greatly to advancements in vaccines, medical treatments, and other control and prevention strategies for tropical and other infectious diseases. Current deployments in desert environments have provided continued research and progress in infectious disease control, treatment, and prevention, despite a relative decrease in civilian medical …

Undergraduate And Graduate Course Descriptions, 2014 Summer, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Summer 2014.

Pharmacokinetics And Pharmacodynamics Of Antifungals In Children And Their Clinical Implications, Chris Stockmann, Jonathan E. Constance, Jessica K. Roberts, Jared Olson, Elizabeth H. Doby, Krow Ampofo, Justin Stiers, Michael G. Spigarelli, Catherine Mt Sherwin

Pediatrics Faculty Publications

Invasive fungal infections are a significant cause of morbidity and mortality in children. Successful management of these systemic infections requires identification of the causative pathogen, appropriate antifungal selection, and optimisation of its pharmacokinetic and pharmacodynamic properties to maximise its antifungal activity and minimise toxicity and the emergence of resistance. This review highlights salient scientific advancements in paediatric antifungal pharmacotherapies and focuses on pharmacokinetic and pharmacodynamic studies that underpin current clinical decision making. Four classes of drugs are widely used in the treatment of invasive fungal infections in children, including the polyenes, triazoles, pyrimidine analogues and echinocandins. Several lipidic formulations of …

Adverse Health Effects Of Intestinal Parasitic Infections In Rural Peruvian Clinic Patients, Jonathan M. Stofer

Master of Public Health Program Student Publications

Intestinal Parasitic Infections (IPIs) pose a significant global health concern. IPIs annually contribute to 3.5 billion infections and 450 million illnesses worldwide. In hyperendemic countries, IPIs pose a significant economic and health burden, especially in rural areas. IPIs have many routes of transmission and cause a wide range of symptoms associated largely with poor health, impeded growth, and worsening of secondary infections. Such diseases are widespread in poor communities living in the Peruvian Amazon. This study aims to describe common chief complaints, diagnoses, treatments, as well as behaviors and practices associated with IPIs presenting in clinic patients. As part of …

Wsu Research News, Spring/Summer 2014, Office Of Research And Sponsored Programs, Wright State University

WSU Research News

A seventeen page newsletter of the WSU Research News. The WSU Research News was published monthly beginning in June of 1968 and issued by the Office of Research Development. This newsletter was created to provide information to the WSU faculty about the availability of outside funds for research and educational programs, new developments that may affect availability of funds, and general information on research and educational activities at Wright State University.

Vital Signs, Spring 2014, Boonshoft School Of Medicine

Vital Signs

A sixty page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

State Zoonotic Disease Program Structure In The United States: Implications For Local Public Health, Dustin W. Ratliff

Master of Public Health Program Student Publications

Objective: The purpose of this research was to assess to current status of zoonotic disease biosurveillance in the United States.

Methods: A questionnaire was administered to 53 state zoonotic disease program representatives in the United States and Puerto Rico. The questionnaire assessed the structure of zoonotic disease biosurveillance in the respective states, current biosurveillance activities such as testing arthropods for pathogens, information provided to local public health on zoonotic disease, and opinions of the current state of zoonotic disease surveillance. A website assessment was conducted to identify fact sheets that are provided by states on vectors of diseases of public …

One Health: Veterinary Involvement And Zoonoses In Humans, Jasmine Cheeks

Master of Public Health Program Student Publications

Introduction: As veterinarians are often first to identify zoonotic disease events in animals, their involvement in One Health should be facilitated and strengthened by support from zoonotic disease surveillance systems and health regulations specific to zoonotic disease surveillance.

Objectives: To identify relatable trends between the relationship of the number of active veterinary professionals and the incidence of zoonotic diseases in the developed countries of Australia, Brazil, Czech Republic, Denmark, Ireland, Israel, Netherlands, Spain, and the United States of America. Another objective was to illustrate potential barriers current health regulations place on veterinary contributions to One Health surveillance. Methods: Data were …

The Importance Of The Young Invincibles To The Success Of The Affordable Care, Ethel K. Ishimwe

Master of Public Health Program Student Publications

Health care reform in the United States, as codified in the Affordable Care Act (ACA), includes an individual mandate to insure that all citizens are participants in public or privately funded health insurance programs. Universal participation insures that the national risk pool of insured persons will include the broadest spectrum of patient utilizers from the very healthy, who are low utilizers, to the very sick who are high utilizers of health care services. It is only through this high level of participation that the increased services and cost savings of health care reform can be realized. Key to this comprehensive …

Polish Healthcare System In Transition - Perceptions Of The Old And New Systems, Paul Puchta

Master of Public Health Program Student Publications

Poland is the largest country in central Europe. During the Second World War (WWII) Poland lost 39% of its physicians. After WWII, Poland fell under Soviet influence. Socialist parties dominated its government until 1989. Poland was the first country from the Soviet block to adopt economic reforms and turn away from centrally planned system.

Poland is presently a stable democracy with a growing economy, and was accepted to the European Union as a full –fledged member in May 2004. Startling results of the population perception of national healthcare system were published in 2013. Polish customers rated current system poorly, giving …

Is Public Health - Dayton & Montgomery County's Level One Food Safety Certification Training Effective?, Matthew M. Tyler

Master of Public Health Program Student Publications

The objective of the culminating experience was to evaluate the effectiveness of Public Health – Dayton & Montgomery County’s (PHDMC) Level One Food Safety Certification class. Pre-training and post-training quiz score data from approximately 692 participants were examined. Paired t-tests were used to evaluate change in scores, overall, on individual questions, and by job responsibility. There was significant improvements in quiz scores both aggregately (20.6%) and also by individual questions, except for question one which assessed how people could become ill from improper food safety. The temperature related questions were answered incorrectly the most but also showed the most improvement. …

Increasing Chlamydia Retesting Rates In Std Clinics, Michelle L. Bellando

Master of Public Health Program Student Publications

Background: Chlamydia is the most common STD in the United States (Mishori, McClaskey, & WinklerPrins, 2012). Due to the high reinfection rate of Chlamydia, the CDC recommends retesting three months after initial treatment (Park, Amey, Creegan, Barandas, & Bauer, 2010).

Objective: The purpose of this study is to investigate strategies that might improve STD follow-up rates in a clinic setting.

Methods: Public Health - Dayton and Montgomery County STD clinic patients 18 years and older who tested positive for NonGonococcal Urethritis (NGU) or Mucopurulent Cervicitis (MPC) and who agreed to participate were given an opinion survey.

Results: Of the 31 …

Implementation Of A Total Knee Arthroplasty Evidence Based Practice Guideline Quality Improvement Project In A Va Orthopedic Surgical Setting To Reduce Surgical Infections, Paula A. Kimpton

Doctor of Nursing Practice Program Projects

The prevention of surgical site infections, specifically orthopedic surgery cases, has been cited as the most preventable source for morbidity and mortality for patients undergoing total knee arthroplasties (TKA). In the most recent Veteran Affairs (VA) National Surgery Office Quarterly Report (July 1, 2012 through June 30, 2013), a problem with surgical site infections was identified in patients with TKA surgery at Dayton Veterans Affairs Medical Center (VAMC). The Dayton VAMC had a 5.3% TKA surgical infection rate versus 1.3% nationally.

The purpose of this quality improvement project was to decrease post-operative TKA infection rates with utilization of evidence based …

Impact Of Poor Retention In Hiv Medical Care On Time To Viral Load Suppression, Timothy N. Crawford, Wayne T. Sanderson, Alice Thornton

Family Medicine Faculty Publications

Objective: The purpose of this study was to evaluate how poor retention in HIV care impacts time to viral suppression after initiating highly active antiretroviral therapy. Methods: A retrospective cohort study design, employing a medical chart review, was conducted at an academic infectious disease clinic at the University of Kentucky. Patients seeking care between 2003 and 2011 were included in the study. A log-normal model was employed to determine the factors associated with time to viral suppression. Results: Of the 532 patients in the study, 426 (80.1%) patients were virally suppressed. Controlling for insurance status, race, baseline CD4 counts, and …

Best Practices: A Network Approach Of The Mandatory Influenza Vaccination Among Healthcare Workers, Greg Attenweiler, Angie Thomure

Master of Public Health Program Student Publications

A network simulation was applied to hospital social networks improve the influenza vaccination rate of healthcare workers in a healthcare system. Social network methods can be used to develop an understanding of structures of social relations. Over 200,000 U.S. patients are hospitalized annually for influenza, which attributes to 36,000 deaths and is the sixth leading cause of death in adults. The best way to prevent influenza each year is by receiving the influenza vaccination. The typical influenza vaccination rate among healthcare workers is 40- 50%. A Healthy People 2020 objective is to increase the percentage of healthcare workers who are …

Integration Of Early Clinical Experience And Population Health In Undergraduate Medical Education, Thang N. Vu, Josephine Mensah-Dapaah

Master of Public Health Program Student Publications

Objective: In order to better prepare physicians to face the challenges in health care delivery today, educators have pushed for the integration of core population health competencies into undergraduate medical education. The goal is to equip future physicians with the necessary skills to not only improve the health of an individual, but also be able to advocate for a community and meet the health needs of a population. The purpose of this research study is to propose a plan to evaluate the pilot program Early Meaningful Clinical Experience (EMCE) at the Boonshoft School of Medicine at Wright State University.

Methods: …

Why Is Living Fast Dangerous? Disentangling The Roles Of Resistance And Tolerance Of Disease, James P. Cronin, Megan A. Rúa, Charles E. Mitchell

Biological Sciences Faculty Publications

Primary axes of host developmental tempo (HDT; e.g., slow-quick return continuum) represent latent biological processes and are increasingly used to a priori identify hosts that contribute disproportionately more to pathogen transmission. The influence of HDT on host contributions to transmission depends on how HDT influences both resistance and tolerance of disease. Here, we use structural equation modeling to address known limitations of conventional measures of resistance and tolerance. We first provide a general resistance-tolerance metamodel from which system-specific models can be derived. We then develop a model specific to a group of vector-transmitted viruses that infect hundreds of grass species …

An Evaluation Of The Chronic Disease Self-Management Program, Joan Sevy Majers

Doctor of Nursing Practice Program Projects

The prevalence and costs of chronic disease continue to escalate with the aging of the population and continued advancements in medical care. Self-management of chronic disease may be an alternative approach to care that could assist in moving away from a disease-oriented model to health-oriented one. Outcomes from chronic disease self-management programs are promising but inconsistent across disease entities and populations. Among the Veteran population, chronic disease self-management programs have been implemented in a number of Veteran Affairs facilities. The purpose of this project was to evaluate specific outcomes from the chronic disease self-management program conducted in the five medical …

Undergraduate And Graduate Course Descriptions, 2014 Spring, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Spring 2014.

Complexity Of Breastfeeding Health Policy In Tanzania, Africa, Theresa Thompson

Master of Public Health Program Student Publications

Background: The purpose of this study was to investigate Tanzanian health policy regarding the protection and promotion of breastfeeding.

Country Profile: Tanzania is a United Republic composed of the mainland and also the islands of Zanzibar. Tanzania is located in east Africa with a population of approximately 46 million. About 1.6 million babies are born each year in Tanzania, however only approximately 140,000 are registered annually. Tanzania’s infant mortality rate is 68 infant deaths per 1000 live births. Tanzania makes up for approximately 0.5% of the world population but 2% of the global infant death.

Approaches: In this study, the …

Differentiation Of U-937 Monocytes To Macrophage-Like Cells Polarized Into M1 Or M2 Phenotypes According To Their Specific Environment: A Study Of Morphology, Cell Viability, And Cd Markers Of An In Vitro Model Of Human Macrophages, Fatma Husien S. Abdulhadi

Browse all Theses and Dissertations

In this study, the human leukemic monocyte lymphoma cell line U-937 was used as an in vitro model for monitoring monocyte/macrophage differentiation. Phorbol 12- myristate (13) (PMA) was used to activate U-937 cells into macrophage-like cells (M0). After 24 hours of PMA treatment, non- adherent U-937 cells became tightly adherent to the culture plates forming M0 cells. M0 cells were then polarized into the M1 macrophage phenotype by treatment with LPS and IFN-γ for another 24 hours. Each of the cytokines IL-4, IL-13, or IL-10 was applied separately to three M0 cultures for 24 hours to induce the M2 macrophage …

Socs1/Socs3 Expression And Virus Replication Of Denv2 And Hsv-1 In Cytokine-Polarized Subsets Of Raw 264.7 Macrophages, Nagarjuna Reddy Cheemarla

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Cytokine activation of macrophages leads to "macrophage polarizatio" The M1 subset is polarized by exposure to lipopolysaccharide (LPS) and interferon-gamma (IFN-γ) and M2 polarized cells develop after exposure to interleukin-4 (IL-4) or IL-13. In this study, the RAW 264.7 murine macrophage cell line was used to study the effect herpes simplex virus-Type I (HSV-1) and Dengue virus serotype-2 (DENV2) infections have on cultures of unpolarized (M0) or polarized subsets. The macrophage subsets were characterized using cluster of differentiation markers CD14 and CD86. Uninfected M1 macrophages showed up regulation in expression of the co-stimulatory factor B7.2 (CD86) compared to expression by …

Development Of A Co-Culture System To Mimic The Transfection Of Hsv-1 From Keratinocytes To Neuronal Cells, David A. Dixon

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To more closely mimic the in vivo progression of HSV-1 a novel in vitro method was created. In this study HEL-30 keratinocytes were infected with a 0.1 MOI of HSV-1 and plated unto a membrane with 8μm diameter pores. The membrane insert was then placed into culture wells that contained Neuro-2a cells (N2A). The neurites from the neuronal cells made cell-to-cell contact with the infected HEL-30 cells and the virus was transmitted into the neuronal cells. To determine if infection occurred in the N2A cells the cells were lysed and the lysate incubated with Vero cells to titrate virus plaque …

White Blood Cell Counts, Parasite Prevalence, And Plasma Cortisol Levels Of Dogs In A County Animal Shelter: Changes Over Days And Impact Of A Program Of Repeated Human Interaction, Emily S. Dudley

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Animal shelter housing is highly stressful for a dog, compromising welfare and leading to undesirable behaviors and unknown health consequences. We documented the changes in circulating numbers of white blood cells, plasma cortisol, and fecal parasite shedding of dogs housed for 10 days at a county animal shelter. White blood cell changes were most prominent on Day 10 after arrival to the shelter. Changes included increased total leukocytes, mature neutrophils, and lymphocytes, with less consistent increases in monocytes and neutrophil to lymphocyte ratio (N:L). Fecal parasite shedding was elevated and not affected by day. Cortisol levels of shelter dogs declined …

Identification Of The Sites Of Action Of Inhibitors Of Mammalian Phospholipase D2 (Pld2) And The Role Of Interacting Protein Partners, Ramya Ganesan

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Phospholipase D (PLD) is a key enzyme for the remodeling of phospholipids in the cell membrane. PLD has been implicated in many physiological functions such as chemotaxis and phagocytosis as well as pathological functions such as ischemia/reperfusion and cancer metastasis. Several small molecule inhibitors of PLD have been recently developed to overcome these pathological effects. We have concentrated on 5-Fluoro-2-Indolyl des-Chlorohalopemide (FIPI) which is an indole derivative of halopemide that inhibits the two mammalian isoforms PLD1 and PLD2. We also concentrate on N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,-8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide (NFOT) and N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide (NOPT) that are specific inhibitors of the PLD2 isoform. In spite of knowing their …

Comparison Between Flow Cytometry And Bead Method In Counting Cd4 And Cd8 T Lymphocytes In Mouse Spleen Cells Suspension, Abdulrahman Abdalla Allabidi

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The flow cytometry is gold standard method to count CD4, CD8 human T lymphocytes, and calculate CD8 to CD4 ratio in HIV patients peripheral blood to stage them and monitor their response to treatment. In this study, a comparison was made by counting CD4and CD8 mouse spleen T lymphocytes by flow cytometry, and a method involving antibody coated latex beads. The bead method yielded results comparable to those obtained by flow cytometry. These results indicate that antibody coated beads are suitable to determine CD4 and CD8 + T lymphocytes counts in situation where flow cytometry is not readily available.

Effect Of Herpes Simplex Virus-1 On Macrophage Cd Marker Expression, Hind Obaid Albeshri

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Macrophages are specialized phagocytic cells derived from the peripheral blood mononuclear cells. Macrophages can assume M1 or M2 cellular states upon activation with specific cytokines. Upon activation, macrophages produce either pro- or anti- inflammatory cytokines and thereby perform their functions of antigen engulfment and debris clearance. Macrophages have several cell surface cluster differentiation (CD) markers including CD80, CD163 and CD200R that differentiate M1 macrophages from M2. Downstream signaling and cytokine production varies based on the interaction between the specific CD marker and antigen.

The present study was aimed at analyzing and comparing the effects of HSV-1 infection on un-polarized and …

Elucidating The Effects Of Tcdd On The Polymorphic Human Hs1,2 Enhancer, Abdullah Freiwan

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent environmental toxin known to inhibit immunoglobulin (Ig) gene expression in various animal studies. We have identified the mouse 3'Ig heavy chain regulatory region (3'IgH RR) as a sensitive transcriptional target of TCDD, which may mediate the inhibitory effect of TCDD on Ig expression. Interestingly, the human hs1,2 enhancer is polymorphic and has been associated with a number of autoimmune diseases.

Suggesting a species difference, TCDD inhibited mouse hs1,2 enhancer activation and activated basal human hs1,2 (hs-hs1,2) enhancer activity in the mouse B-cell line. The objective of this study was to elucidate the effects of TCDD …