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Wsu Board Of Trustees Meeting Minutes, April 30-May 1, 2015

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on April 30-May 1, 2015.

Wsu Research News, Spring 2015, Office Of Research And Sponsored Programs, Wright State University

WSU Research News

An eighteen page newsletter of the WSU Research News. The WSU Research News was published monthly beginning in June of 1968 and issued by the Office of Research Development. This newsletter was created to provide information to the WSU faculty about the availability of outside funds for research and educational programs, new developments that may affect availability of funds, and general information on research and educational activities at Wright State University.

Adenovirus Entry From The Apical Surface Of Polarized Epithelia Is Facilitated By The Host Innate Immune Response, Poornima L.N. Kotha, Priyanka Sharma, Abimbola O. Kolawole, Ran Yan, Mahmoud Alghamri, Trisha L. Brockman, Julian Gomez-Cambronero, Julian Cambronero

Biological Sciences Faculty Publications

Prevention of viral-induced respiratory disease begins with an understanding of the factors that increase or decrease susceptibility to viral infection. The primary receptor for most adenoviruses is the coxsackievirus and adenovirus receptor (CAR), a cell-cell adhesion protein normally localized at the basolateral surface of polarized epithelia and involved in neutrophil transepithelial migration. Recently, an alternate isoform of CAR, CAREx8, has been identified at the apical surface of polarized airway epithelia and is implicated in viral infection from the apical surface. We hypothesized that the endogenous role of CAR^Ex8 may be to facilitate host innate immunity. We show that IL-8, …

Wsu Board Of Trustees Meeting Minutes, February 12-13, 2015

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on February 12-13, 2015.

Department Of Surgery Update, February 2015, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains note about Margaret M. Dunn, M.D., being appointed dean of the Boonshoft School of medicine, a message from the chair, a list of important dates, a call for abstracts, scholarly activity and more.

Immunotherapy For Human Breast Cancer, Nasrah Ali Al Kamal

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Al Kamal, Nasrah. M.S. Program of Microbiology and Immunology, Wright State University, 2015.Immunotherapy for Human Breast Cancer. The study focuses on the methodologies that are used in breast cancer therapy. The review finds major evolutions of these methods and the influence they have made on the increased survival rates in cancer patients. There is also a projection of the processes that are involved in the therapy practices and the way the protocols have been improved over time. The various stages of cancer treatment project the various aspects of better performance articulations in the therapy sector. There is also reference to …

Emergency Preparedness For A Radiological Disaster: Davis-Besse Nuclear Power Plant Release, Meghan A. Jackson

Master of Public Health Program Student Publications

Over the course of human history, man has tried to find an ultimate source of energy. Nuclear energy has been paramount to this sustainability. There have been over 420 nuclear related disasters since 1944 and preparedness has only marginally increased in response. This study examines the potential outfall of a major nuclear accident within the United States at the Davis-Besse Nuclear Power Plant. Using data from the incident that occurred in Fukushima, Japan in 2011, radiation plumes were plotted using HotSpot software over northern Ohio to examine the dispersion and concentration of radioactive particles and their potential health effects on …

Dominicanas Redefining Hiv In San Pedro De Macorís, Emily Frances Surico

Master of Public Health Program Student Publications

This study explored the social support among women impacted by human immunodeficiency virus (HIV) living in the Province of San Pedro de Macorís, República Dominicana. Social support is one way that social networks can influence health status. Social networks impact health behaviors and overall health outcomes which include infectious diseases, morbidity rates, and mortality rates. Social networks can promote health and minimize risky behavior: “cohesive, supportive networks may themselves blunt stressful experiences and enable people to resist risky behavior and maintain healthier choices” (Berkman, Kawachi, & Krishna, 2014, p. 248). Qualitative methods were used to explore how social support systems …

The Implications Of Hiv Treatment On The Hiv-Malaria Coinfection Dynamics: A Modeling Perspective, F. Nyabadza, B. T. Bekele, Megan A. Rúa, D. M. Malonza, N. Chiduku, M. Kgosimore

Biological Sciences Faculty Publications

Most hosts harbor multiple pathogens at the same time in disease epidemiology. Multiple pathogens have the potential for interaction resulting in negative impacts on host fitness or alterations in pathogen transmission dynamics. In this paper we develop a mathematical model describing the dynamics of HIV-malaria coinfection. Additionally, we extended our model to examine the role treatment (of malaria and HIV) plays in altering populations’ dynamics. Our model consists of 13 interlinked equations which allow us to explore multiple aspects of HIV-malaria transmission and treatment. We perform qualitative analysis of the model that includes positivity and boundedness of solutions. Furthermore, we …

Application Of Fluorescence In Situ Hybridization For Visualization And Quantification Of Human Gastrointestinal Microbiota, Alexander M. Gordon

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The microbiota of the human gastrointestinal tract is the focus of current research due to their role in human health and disease. Modern methods characterize the communities of gut microbiota through the use of culture independent techniques. Technologies such as microarrays and next generation sequencing (NGS) determine microbial profiles by analyzing the pool of 16S ribosomal small subunit RNA genes in the community. These techniques operate through the measurement of genomic content rather than through direct analysis of cells. This approach predisposes the methods to discrepancies and bias. In contrast, the use of fluorescence in situ hybridization (FISH) to analyze …

Growing Up With Chronic Kidney Disease: What Parents And Children Really Want To Know, Uptal D. Patel, Debbie S. Gipson, Abiodun Aderogba Omoloja, Caitlin Wise Carter

Pediatrics Faculty Publications

Adolescents with chronic kidney disease have specific questions about how their disease will affect their quality of life, but they may not always bring this up with their nephrologist. This session is designed to provide pediatricians and pediatric nephrologists with practical information to provide to adolescents with chronic kidney disease and their families. All providers who care for adolescents with renal disease need to be equipped to educate this high risk population and help them navigate through this vulnerable period. This session is designed to explore issues related to athletic participation, academic performance, substance use and abuse and sexual and …

Development Of Population Protective Procedures For A Radiological Event, Daniel A. Baker

Master of Public Health Program Student Publications

Objective: The purpose of this investigation was to evaluate the execution of emergency preparedness procedures of the west central Ohio region during a radiological event. Preparedness plans were generated by the Dayton Metropolitan Medical Response System and Public Health – Dayton and Montgomery County, which would later be disseminated to eight counties in west central Ohio.

Methods: Two live scenarios, a region-wide functional exercise and a Medical Reserve Corps training exercise, were used to test different procedures and protocols for a radiological event relevant to various first response agencies (public health, law enforcement, emergency medical systems, hospitals, etc.). Exercise evaluation …

Relactation In Emergencies, Ashley N. Franz

Master of Public Health Program Student Publications

Disaster situations in the United States are unique entities that require solutions which are well thought out, appropriate for the population and planned well in advance. Infant and young child feeding in emergencies is no exception. While in peacetime infants may be safely nourished with both breastmilk and infant formula, disaster situations often add a level of complexity to feeding with infant formula, including lack of access to potable water and ability to effectively sterilize feeding items. Such complexities, along with the important and undeniable fact that breastmilk is the ideal form of food for all babies (and especially in …

Decompression Illness In United States Air Force: High Risk Occupations, Jaime Rojas

Master of Public Health Program Student Publications

Introduction: Although the physics of decompression sickness (DCS) is well understood, an individual’s unique response to the bubble formation places the United States Air Force’s (USAF) Airmen and missions at risk. We identified 123 decompression sickness diagnoses in the USAF between the years 2005-2010. From these cases we attempted to identify an association between the disease and the two occupations that are routinely performing high-altitude duties, the U2 pilot and the hypobaric chamber technician. Methods: A Chi-squared analysis was performed to identify if DCS was associated with the high-altitude occupations, tobacco, or alcohol. Results: There association between DCS and U2 …

Improving Compliance With Clinical Practice Guidelines To Reduce Urinary Tract Infection In Long Term Care, Charman L. Miller

Doctor of Nursing Practice Program Projects

This evidence-based clinical change project addressed the clinical problem trigger of increased rates of urinary tract infections and related unplanned discharges in a rural Ohio nursing center. The clinical change involved the implementation of a nursing-driven protocol for suspected Urinary Tract Infection (sUTI) based on the American Medical Director’s Association Clinical Practice Guideline: Common Infections. An interdisciplinary team approach to evidence-based clinical change was utilized through use of the Iowa Model of Evidence-based Practice to Promote Quality Care. Both the process and the intervention were evaluated through analysis of outcome data including rates of urinary tract infection, compliance with the …

Determining The Role Of The Ahr In Immunoglobulin Expression And Class Switch Recombination, Bassam Fawaz Kashgari

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The aryl hydrocarbon receptor (AhR) is a ligand-activated cytosolic transcription factor that regulates xenobiotic-metabolizing enzymes. It mediates the toxicity of various environmental chemicals such as 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD). TCDD inhibits the differentiation of B cells into antibody-secreting cells and inhibits immunoglobulin (Ig) expression in various animal models. We have previously determined that TCDD-induced inhibition of the mouse Ig heavy chain gene (mo-Igh) is AhR-dependent. This inhibition may be mediated by binding of the AhR to dioxin response elements (DREs) within the 3'Igh regulatory region (3'IghRR) and inhibition of 3'IghRR activity, a significant transcriptional regulator of Ig expression. However, there are structural …

Developing Proteomic And Cytokine Biomarkers For Vulvodynia, Ashvin Iyer

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Vulvodynia is a chronic, heterogeneous, and multifactorial disease. This condition may affect up to 18 percent of the female population including Caucasians, African Americans, Africans and Hispanics particularly those sexually active at child bearing age. The etiology of this condition is complex and multifactorial and it is frequently accompanied by physical disabilities, psychological distress and sexual dysfunction. Clinically, vulvodynia can be generalized or localized and pain can be provoked or unprovoked. Patients may also describe vulvar paresthesias or dysesthesias that may last hours. The International Society for the Study of Vulvar Disease (ISSVD) recognizes vulvar pain related to a specific …

Silver Nanoparticles Inhibit The Binding And Replication Of Dengue Virus, Kelley J. Williams

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Dengue is an emerging hemorrhagic fever virus and widely considered the most important arbovirus in the world. The CDC and the World Health Organization estimates Dengue virus (DENV) infects 50-400 million people annually in the tropical and subtropical regions of the world. More than 500 thousand of these will develop severe infection and approximately 22 thousand will lead to death. Dengue virus (DENV) is a positive-sense RNA virus that exists in 4 antigenic serotypes. An immunological phenomenon called antibody-dependent enhancement (ADE) leaves a DENV victim vulnerable to increased risk of subsequent infections. Secondary infections with DENV are known to increase …

The Impact Of Hsv-1 Infection On Cell Viability, Morphology, And Cd Markers Expression By Unpolarized And Cytokine-Polarized J774a.1 Mouse Macrophages, Sarah Saad Alsharif

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Macrophages play an important role in the immune system, particularly in neutralizing pathogens via phagocytosis and the production of multiple cytokines and chemokines that control infection after exposure to specific stimuli. Macrophages exhibit two different phenotypes, M1 and M2. This study evaluated the role of Suppressors of cytokine signaling (SOCS)1 and SOCS3 on Herpes Simplex Virus (HSV-1) infection of polarized macrophages, cell viability, cell morphology, and the expression of cell surface CD markers. I hypothesized that J774A.1 murine macrophages cells in the naive state (M0), and M1 and M2 phenotypes would display differences in CD markers CD80,CD163, and CD200R, cell …

Inhibition Of Nectin-1 And Herpes Virus Entry Mediator (Hvem) Using Monoclonal Antibodies Decreases Hsv-1 Entry Into Neuro-2a Cells, Erica Marie Rinehart

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This study examines the effects of blocking the nectin-1 and Herpes Virus Entry Mediator (HVEM) receptors on Neuro-2a (N2a) cells in order to prevent HSV-1 infection. These two receptors have been identified as a primary and secondary mode of entry for HSV-1. Since there was some debate about the correct serum level to be used in growth media for healthy N2a cells, three concentrations (2%, 5%, 10%) were used to examine relative growth and neurite development, in addition to examining possible differences in infectivity levels in all other experiments. There was a difference in general morphology, with neurite abundance and …

Is Polyvinylidene Diflouride (Pvdf) Film Biocompatible In The Murine Cochlea?, Robert Maxwell Jaggers

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Polyvinylidene fluoride (PVDF) film, a biomaterial that is an integral part of a Totally Implantable Sustainable Hearing Aide (TISHA) device, was examined to determine its biocompatibility within the murine cochlea. The biofilm was implanted in the ear using a round window cochleostomy in 7-9 week old male C57BL/6 mice. Three test groups containing seven mice each were implanted with PVDF film. Each mouse received a sham surgery on the non-implanted cochlea. Three test groups were examined at 48 hours, 3 weeks, and 3 months. At the end of this time the mouse was euthanized, the tissue containing the cochlea was …

The Use Of Antibody-Coated Latex Beads To Determine Single Positive And Double Positive Mouse Spleen Cells Expressing Cd5 And/Or Cd19 Glycoproteins, Abdulrazzag Abdulaziz Othman

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Flow cytometry is the standard method used to diagnose, stage, and monitor patients' response to the treatment given by counting the numbers of CD5, CD19 and CD5+ CD19+ B lymphocytes. In this study, a comparison was done between numbers of single CD5+, single CD19+ and dual CD5+ CD19+ mouse spleen B lymphocytes using flow cytometry and antibody-latex beads. The bead method involved antibody-coated latex bead and yielded results similar to those of flow cytometry. For cells exhibiting both markers (CD5+ CD19+), the bead method used antibody-coated beads of two different colors yielded similar results to those of flow cytometry results. …

The Predictive Power Of Non-Pathological Psychological Variables In Weight Loss Surgery, Tiffany Milligan

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According to the World Health Organization and National Institutes of Health, obesity is a global health problem. Worldwide, obesity is the fifth-leading cause of death. Weight loss surgeries such as gastric banding, sleeve gastrectomy, and gastric bypass surgery have become increasingly popular methods to manage intractable obesity in the United States. Such surgeries have inherent risks, both medical and psychosocial, and as a result, candidates for weight loss surgery routinely undergo pre-surgical evaluations to determine their suitability for weight loss procedures. The current study was done in partnership with Kettering Bariatrics in Kettering, Ohio, and is an analysis of the …

Endothelial Cell Derived Mvs And Exosomes: Release And Functional Study, Langni Liu

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Extracellular vesicles are membrane derived vesicles exists in all organs. The two major functioning extracellular vesicles are exosomes (EXMs) and microvesicles (MVs). EXMs released from cell membranes via exocytosis with size between 30-150 nm in diameter and MVs directly budded from plasma membrane and size between 100-1000 nm. Ceramide is one of the most important factor in lipid mechanism for EXM release and also associated with MV release. Ceramide generated from breakdown of sphingomyelin by neutral sphingomyelinase (nSMase). In this study, we used an nSMase inhibitor (GW4869) and an analogue of ceramide (C6-ceramide) to modulate the release of MVs and …

Toxic Metal Effect On Filamentous Fungi Isolated From The Contaminated Soil Of Multan And Gujranwala, Anam Rasool, Shazia Irum

Journal of Bioresource Management

Considering the importance of filamentous fungi for bioremediation of wastewater and contaminated soils, this study was planned to investigate the metal tolerance potential of indigenous filamentous fungi. Certain metals are important to biological actions. However all metals, whether essential or inessential will show toxicity at certain levels. During 2012 total 17 fungi were isolated and preserved from contaminated peri-urban agricultural areas of Multan and Gujranwala for further detail investigation of heavy metal tolerance. Aspergillus niger, Aspergillus fumigatus and Aspergillus flavus isolated from both soil and water samples while Aspergillus terreus and Penicillium sp were only isolated from soil samples …

Wsu Research News, Fall/Winter 2014, Office Of Research And Sponsored Programs, Wright State University

WSU Research News

A twenty page newsletter of the WSU Research News. The WSU Research News was published monthly beginning in June of 1968 and issued by the Office of Research Development. This newsletter was created to provide information to the WSU faculty about the availability of outside funds for research and educational programs, new developments that may affect availability of funds, and general information on research and educational activities at Wright State University.

Flight Physician - October, 2014, Civil Aviation Medical Association

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A twelve page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Cama Newsletter - August, 2014, Civil Aviation Medical Association

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A twelve page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Undergraduate And Graduate Course Descriptions, 2014 Fall, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Fall 2014.

Cama Newsletter - June, 2014, Civil Aviation Medical Association

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A twelve page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.