Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Western University

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 421 - 450 of 1465

Full-Text Articles in Entire DC Network

Hippocampal Gaba Enables Inhibitory Control Over Unwanted Thoughts, Taylor W. Schmitz, Marta M. Correia, Catarina S. Ferreira, Andrew P. Prescot, Michael C. Anderson Dec 2017

Hippocampal Gaba Enables Inhibitory Control Over Unwanted Thoughts, Taylor W. Schmitz, Marta M. Correia, Catarina S. Ferreira, Andrew P. Prescot, Michael C. Anderson

Brain and Mind Institute Researchers' Publications

© 2017 The Author(s). Intrusive memories, images, and hallucinations are hallmark symptoms of psychiatric disorders. Although often attributed to deficient inhibitory control by the prefrontal cortex, difficulty in controlling intrusive thoughts is also associated with hippocampal hyperactivity, arising from dysfunctional GABAergic interneurons. How hippocampal GABA contributes to stopping unwanted thoughts is unknown. Here we show that GABAergic inhibition of hippocampal retrieval activity forms a key link in a fronto-hippocampal inhibitory control pathway underlying thought suppression. Subjects viewed reminders of unwanted thoughts and tried to suppress retrieval while being scanned with functional magnetic resonance imaging. Suppression reduced hippocampal activity and memory …


Employee Commitment Before And After An Economic Crisis: A Stringent Test Of Profile Similarity, John P. Meyer, Alexandre J. S. Morin, Arzu Wasti Nov 2017

Employee Commitment Before And After An Economic Crisis: A Stringent Test Of Profile Similarity, John P. Meyer, Alexandre J. S. Morin, Arzu Wasti

Psychology Publications

Researchers have recently begun to take a person-centered (profile) approach to investigate how the affective, normative, and continuance commitment mindsets combine within the three-component model of organizational commitment (Meyer & Allen, 1991). The meaningfulness of the profiles identified in this research depends, in part, on evidence that similar profiles emerge across samples, particularly those drawn for a common population. We conducted a particularly stringent test of similarity by comparing profiles for samples of employees drawn from a large Turkish conglomerate prior to (N = 346) and following (N = 797) a major economic crisis. Using procedures recently introduced by Morin …


Complement Coercion: The Joint Effects Of Type And Typicality, Alessandra Zarcone, Ken Mcrae, Alessandro Lenci, Sebastian Padó Nov 2017

Complement Coercion: The Joint Effects Of Type And Typicality, Alessandra Zarcone, Ken Mcrae, Alessandro Lenci, Sebastian Padó

Psychology Publications

Complement coercion (begin a book → reading) involves a type clash between an event-selecting verb and an entity-denoting object, triggering a covert event (reading). Two main factors involved in complement coercion have been investigated: the semantic type of the object (event vs. entity), and the typicality of the covert event (the author began a book → writing). In previous research, reading times have been measured at the object. However, the influence of the typicality of the subject–object combination on processing an aspectual verb such as begin has not been studied. Using a self- paced reading study, we manipulated semantic type …


Psychological Well-Being In Sport: Examining The Construct Validity Of A Modified Version Of The Scales Of Psychological Well-Being, Despina Kouali Nov 2017

Psychological Well-Being In Sport: Examining The Construct Validity Of A Modified Version Of The Scales Of Psychological Well-Being, Despina Kouali

Western Journal of Graduate Research

No abstract provided.


Interdisciplinary Complication Management Of Dislodged Lumbar Interbody Spacer In Pulmonary Artery, Stefan Köhler Nov 2017

Interdisciplinary Complication Management Of Dislodged Lumbar Interbody Spacer In Pulmonary Artery, Stefan Köhler

Brain and Mind Institute Researchers' Publications

We report the case of an intraoperatively dislodged transforaminal lumbar interbody fusion spacer with creation of a traumatic arteriovenous fistula and device migration to the pulmonary artery. Successful minimally invasive angiographic retrieval of the spacer is discussed with special reference to angiographic and surgical treatment strategies and pitfalls.


The Large-Scale Organization Of Shape Processing In The Ventral And Dorsal Pathways, Erez Freud, Jody C. Culham, David C. Plaut, Marlene Behrmann Oct 2017

The Large-Scale Organization Of Shape Processing In The Ventral And Dorsal Pathways, Erez Freud, Jody C. Culham, David C. Plaut, Marlene Behrmann

Brain and Mind Institute Researchers' Publications

Although shape perception is considered a function of the ventral visual pathway, evidence suggests that the dorsal pathway also derives shape-based representations. In two psychophysics and neuroimaging experiments, we characterized the response properties, topographical organization and perceptual relevance of these representations. In both pathways, shape sensitivity increased from early visual cortex to extrastriate cortex but then decreased in anterior regions. Moreover, the lateral aspect of the ventral pathway and posterior regions of the dorsal pathway were sensitive to the availability of fundamental shape properties, even for unrecognizable images. This apparent representational similarity between the posterior-dorsal and lateral-ventral regions was corroborated …


The Open Textbook Toolkit: Seeding Successful Partnerships For Collaboration Between Academic Libraries And University Presses, Mira Waller, William M. Cross, Lillian S. Rigling Oct 2017

The Open Textbook Toolkit: Seeding Successful Partnerships For Collaboration Between Academic Libraries And University Presses, Mira Waller, William M. Cross, Lillian S. Rigling

Western Libraries Publications

Libraries and university presses coexist in a complex and increasingly consolidated scholarly communication ecosystem. Each brings different strengths, values, and viewpoints that can inform and enrich a joint project. In this paper we discuss potential barriers to and benefits of collaboration between academic libraries and university presses and introduce a case study of such a collaboration: the Open Textbook Toolkit. This project, funded by a grant from the Institute of Museum and Library Services, is currently investigating the components needed to support faculty in one discipline, psychology, who are considering adopting open educational resources. By leveraging both library and press …


Taking A Person-Centered Approach To Personality: A Latent-Profile Analysis Of The Hexaco Model Of Personality, Kabir N. Daljeet, Nicholas L. Bremner, Erica A. Giammarco, John P. Meyer, Sampo V. Paunonen Oct 2017

Taking A Person-Centered Approach To Personality: A Latent-Profile Analysis Of The Hexaco Model Of Personality, Kabir N. Daljeet, Nicholas L. Bremner, Erica A. Giammarco, John P. Meyer, Sampo V. Paunonen

Psychology Publications

Our study applies a person-centered approach to the HEXACO model of personality using latent profile analysis (LPA). While the traditional variable-centered approach assumes that the relations among variables within a population are homogenous, the person-centered approach identifies subgroups within samples that have similar scores on several variables of interest, in this case, the six factors of personality. Data from two independent samples were collected at a large North American university. The results of LPA revealed five distinct and interpretable profiles that replicated and were found to be consistent across both samples. We discuss how our findings attest to the meaningfulness …


Vocabulary Learning Benefits From Rem After Slow-Wave Sleep., Laura J Batterink, Carmen E Westerberg, Ken A Paller Oct 2017

Vocabulary Learning Benefits From Rem After Slow-Wave Sleep., Laura J Batterink, Carmen E Westerberg, Ken A Paller

Brain and Mind Institute Researchers' Publications

Memory reactivation during slow-wave sleep (SWS) influences the consolidation of recently acquired knowledge. This reactivation occurs spontaneously during sleep but can also be triggered by presenting learning-related cues, a technique known as targeted memory reactivation (TMR). Here we examined whether TMR can improve vocabulary learning. Participants learned the meanings of 60 novel words. Auditory cues for half the words were subsequently presented during SWS in an afternoon nap. Memory performance for cued versus uncued words did not differ at the group level but was systematically influenced by REM sleep duration. Participants who obtained relatively greater amounts of REM showed a …


Accumulation Of Non-Numerical Evidence During Nonsymbolic Number Processing In The Brain: An Fmri Study, Tali Leibovich, Daniel Ansari Oct 2017

Accumulation Of Non-Numerical Evidence During Nonsymbolic Number Processing In The Brain: An Fmri Study, Tali Leibovich, Daniel Ansari

Brain and Mind Institute Researchers' Publications

Behavioral evidence has shown that when performing a nonsymbolic number comparison task (e.g., deciding which of two dot arrays contains more dots), participants' responses are sensitive to affected by both numerical (e.g., number of items) and non-numerical magnitudes (i.e., area, density, etc.). Thus far it is unclear what brain circuits support this process of accumulating non-numerical variables during nonsymbolic number processing. To investigate this, 21 adult participants were asked to engage in a dot comparison task. To measure the neural correlates of accumulating numerical and non-numerical variables, we manipulated the number of the non-numerical magnitudes that were congruent (correlated with …


Consciousness: Where We Are At, Imants Barušs Oct 2017

Consciousness: Where We Are At, Imants Barušs

Psychology

It is useful every couple of years to take a bird’s eye view of consciousness studies and reflect on what we see. When I look, I still see two streams, one of which is the social and political framework for the study of consciousness, and the other of which is the substance of what we know about consciousness. The former is still largely defined by the extent to which the scientific study of consciousness has been freed from a materialist agenda. The latter includes recent research into the clarity of cognitive functioning in the absence of sufficient neurological support for …


Phase 2 Of Catalise: A Multinational And Multidisciplinary Delphi Consensus Study Of Problems With Language Development: Terminology, Dorothy V.M. Bishop, Margaret J. Snowling, Paul A. Thompson, Trisha Greenhalgh Oct 2017

Phase 2 Of Catalise: A Multinational And Multidisciplinary Delphi Consensus Study Of Problems With Language Development: Terminology, Dorothy V.M. Bishop, Margaret J. Snowling, Paul A. Thompson, Trisha Greenhalgh

Communication Sciences and Disorders Publications

© 2017 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. Background: Lack of agreement about criteria and terminology for children's language problems affects access to services as well as hindering research and practice. We report the second phase of a study using an online Delphi method to address these issues. In the first phase, we focused on criteria for language disorder. Here we consider terminology. Methods: The Delphi method is an iterative process in which an initial set of statements is rated by …


Cooperation Not Competition: Bihemispheric Tdcs And Fmri Show Role For Ipsilateral Hemisphere In Motor Learning, Sheena Waters, Tobias Wiestler, Jörn Diedrichsen Aug 2017

Cooperation Not Competition: Bihemispheric Tdcs And Fmri Show Role For Ipsilateral Hemisphere In Motor Learning, Sheena Waters, Tobias Wiestler, Jörn Diedrichsen

Brain and Mind Institute Researchers' Publications

What is the role of ipsilateral motor and premotor areas in motor learning? One view is that ipsilateral activity suppresses contralateral motor cortex and, accordingly, that inhibiting ipsilateral regions can improve motor learning. Alternatively, the ipsilateral motor cortex may play an active role in the control and/or learning of unilateral hand movements. We approached this question by applying double-blind bihemispheric transcranial direct current stimulation (tDCS) over both contralateral and ipsilateral motor cortex in a between-group design during 4 d of unimanual explicit sequence training in human participants. Independently of whether the anode was placed over contralateral or ipsilateral motor cortex, …


Ventral Striatal Activity Links Adversity And Reward Processing In Children, Niki H. Kamkar, Daniel J. Lewis, Wouter Van Den Bos, J. Bruce Morton Aug 2017

Ventral Striatal Activity Links Adversity And Reward Processing In Children, Niki H. Kamkar, Daniel J. Lewis, Wouter Van Den Bos, J. Bruce Morton

Paediatrics Publications

Adversity impacts many aspects of psychological and physical development including reward-based learning and decision-making. Mechanisms relating adversity and reward processing in children, however, remain unclear. Here, we show that adversity is associated with potentiated learning from positive outcomes and impulsive decision-making, but unrelated to learning from negative outcomes. We then show via functional magnetic resonance imaging that the link between adversity and reward processing is partially mediated by differences in ventral striatal response to rewards. The findings suggest that early-life adversity is associated with alterations in the brain's sensitivity to rewards accounting, in part, for the link between adversity and …


(Re)Grounding Grounded Theory: A Close Reading Of Theory In Four Schools, Tavis Apramian, Sayra Cristancho, Chris Watling, Lorelei Lingard Aug 2017

(Re)Grounding Grounded Theory: A Close Reading Of Theory In Four Schools, Tavis Apramian, Sayra Cristancho, Chris Watling, Lorelei Lingard

Health and Rehabilitation Sciences Publications

The debate over what counts as theory has dominated methodological conversations in grounded theory research for decades. Four of the schools of thought in that debate – Glaserian, Straussian, Charmazian, and Clarkeian – hold different assumptions about what theory is and how it is made. The first two schools understand theory as an abstraction that exactingly accounts for exceptions. The second two schools understand theory as a process of describing voices hidden from public view. While Glaserian and Straussian coding processes focus on coding exceptions, Charmazian and Clarkeian coding processes focus on building a story of the participants or social …


Candid: A Framework For Linking Executive Function And Education, Niki H. Kamkar, J. B. Morton Jul 2017

Candid: A Framework For Linking Executive Function And Education, Niki H. Kamkar, J. B. Morton

Brain and Mind Institute Researchers' Publications

The close association between executive functions (EFs) and educational achievement has led to the idea that targeted EF training might facilitate learning and goal-directed behavior in the classroom. The evidence that training interventions have long-lasting and transferable effects is however decidedly mixed (Melby-Lervåg and Hulme, 2013; Simons et al., 2016). The goal of the current paper is to propose a new CanDiD framework for re-thinking EF and its links to education. Based on findings from basic EF research, the proposed CanDiD framework highlights dynamic and contextual influences on EF and emphasizes the importance of development and individual differences for understanding …


Soft Sides Of Software, Luiz Fernando Capretz, Faheem Ahmed, Fabio Queda Silva Jul 2017

Soft Sides Of Software, Luiz Fernando Capretz, Faheem Ahmed, Fabio Queda Silva

Electrical and Computer Engineering Publications

Software is a field of rapid changes: the best technology today becomes obsolete in the near future. If we review the graduate attributes of any of the software engineering programs across the world, life-long learning is one of them. The social and psychological aspects of professional development is linked with rewards. In organizations, where people are provided with learning opportunities and there is a culture that rewards learning, people embrace changes easily. However, the software industry tends to be short-sighted and its primary focus is more on current project success; it usually ignores the capacity building of the individual or …


Rapid Statistical Learning Supporting Word Extraction From Continuous Speech., Laura J Batterink Jul 2017

Rapid Statistical Learning Supporting Word Extraction From Continuous Speech., Laura J Batterink

Brain and Mind Institute Researchers' Publications

The identification of words in continuous speech, known as speech segmentation, is a critical early step in language acquisition. This process is partially supported by statistical learning, the ability to extract patterns from the environment. Given that speech segmentation represents a potential bottleneck for language acquisition, patterns in speech may be extracted very rapidly, without extensive exposure. This hypothesis was examined by exposing participants to continuous speech streams composed of novel repeating nonsense words. Learning was measured on-line using a reaction time task. After merely one exposure to an embedded novel word, learners demonstrated significant learning effects, as revealed by …


Effects Of Group Functional Behavior-Based Cognitive Behavioral Therapy For Obsessive-Compulsive Behavior In A Youth With Autism Spectrum Disorder, Nicole Neil, Tricia Vause, Heather Jaksic, Maurice Feldman Jul 2017

Effects Of Group Functional Behavior-Based Cognitive Behavioral Therapy For Obsessive-Compulsive Behavior In A Youth With Autism Spectrum Disorder, Nicole Neil, Tricia Vause, Heather Jaksic, Maurice Feldman

Education Publications

Individuals with Autism Spectrum Disorder (ASD) often present with comorbid Obsessive Compulsive Behaviors (OCBs), but little research exists on effective intervention for OCBs. Using a single-case experimental design, this study highlights the efficacy of a Group Functional Behavior-Based Cognitive-Behavior Therapy (Fb-CBT) to reduce OCBs in an 11-year-old youth. Tailored for individuals with ASD, Fb-CBT included traditional CBT components (e.g., psychoeducation, cognitive-behavioral skills training, and exposure and response prevention), functional behavior assessment and intervention, and a group parent-training component. Time-series parent report data and standardized OCB measures showed clinically significant decreases in OCBs, increase in psychosocial functioning, and high consumer satisfaction.


Portrait Des Élèves Issus De L’Immigration En Milieu Scolaire Primaire Défavorisé, Kristel Tardif-Grenier, Isabelle Archambault, Christine Gervais Jun 2017

Portrait Des Élèves Issus De L’Immigration En Milieu Scolaire Primaire Défavorisé, Kristel Tardif-Grenier, Isabelle Archambault, Christine Gervais

Comparative and International Education / Éducation Comparée et Internationale

Les élèves issus de l’immigration sont fortement susceptibles de fréquenter un établissement scolaire situé en milieu défavorisé. À Montréal, deux communautés y sont particulièrement présentes soit les élèves originaires d’Afrique du Nord et des Antilles. Ces élèves, une fois parvenus au secondaire, présentent un profil scolaire, familial et scolaire distinct. Nous en savons cependant bien peu sur ce qui caractérise ces élèves lorsqu’ils sont au primaire. Afin de contribuer au développement des connaissances à ce niveau, la présente étude compare deux groupes d’élèves dont les parents sont nés en Afrique du Nord (n= 98) et dans les Antilles ( …


Older Adults Without Close Kin In The United States, Rachel Margolis, Ashton Verdery Jun 2017

Older Adults Without Close Kin In The United States, Rachel Margolis, Ashton Verdery

Sociology Publications

Objectives: We document the size and characteristics of the population of older adults without close kin in the contemporary United States.

Methods: Using the Health and Retirement Study, we examine the prevalence of lacking different types and combinations of living kin, examine how kinless-ness is changing across birth cohorts, and provide estimates of kinless-ness for sociodemographic and health groups.

Results: In 1998–2010, 6.6% of U.S. adults aged 55 and above lacked a living spouse and biological children and 1% lacked a partner/spouse, any children, biological siblings, and biological parents. Kinless-ness, defined both ways, is becoming more common among adults in …


Has Engagement Had Its Day – What’S Next And Does It Matter?, John P. Meyer Jun 2017

Has Engagement Had Its Day – What’S Next And Does It Matter?, John P. Meyer

Psychology Publications

No abstract provided.


Representation Of Multiple Body Parts In The Missing-Hand Territory Of Congenital One-Handers., Avital Hahamy, Scott N Macdonald, Fiona Van Den Heiligenberg, Paullina Kieliba, Uzay Emir, Rafael Malach, Heidi Johansen-Berg, Peter Brugger, Jody C Culham, Tamar R Makin May 2017

Representation Of Multiple Body Parts In The Missing-Hand Territory Of Congenital One-Handers., Avital Hahamy, Scott N Macdonald, Fiona Van Den Heiligenberg, Paullina Kieliba, Uzay Emir, Rafael Malach, Heidi Johansen-Berg, Peter Brugger, Jody C Culham, Tamar R Makin

Brain and Mind Institute Researchers' Publications

Individuals born without one hand (congenital one-handers) provide a unique model for understanding the relationship between focal reorganization in the sensorimotor cortex and everyday behavior. We previously reported that the missing hand's territory of one-handers becomes utilized by its cortical neighbor (residual arm representation), depending on residual arm usage in daily life to substitute for the missing hand's function [1, 2]. However, the repertoire of compensatory behaviors may involve utilization of other body parts that do not cortically neighbor the hand territory. Accordingly, the pattern of brain reorganization may be more extensive [3]. Here we studied unconstrained compensatory strategies under …


Coordinated Pluralism As A Means To Facilitate Integrative Taxonomies Of Cognition, Jacqueline Anne Sullivan May 2017

Coordinated Pluralism As A Means To Facilitate Integrative Taxonomies Of Cognition, Jacqueline Anne Sullivan

Brain and Mind Institute Researchers' Publications

© 2017 Informa UK Limited, trading as Taylor & Francis Group. The past decade has witnessed a growing awareness of conceptual and methodological hurdles within psychology and neuroscience that must be addressed for taxonomic and explanatory progress in understanding psychological functions to be possible. In this paper, I evaluate several recent knowledge-building initiatives aimed at overcoming these obstacles. I argue that while each initiative offers important insights about how to facilitate taxonomic and explanatory progress in psychology and neuroscience, only a “coordinated pluralism” that incorporates positive aspects of each initiative will have the potential for success.


Heroes Of The Engram, Sheena A. Josselyn, Stefan Köhler, Paul W. Frankland May 2017

Heroes Of The Engram, Sheena A. Josselyn, Stefan Köhler, Paul W. Frankland

Brain and Mind Institute Researchers' Publications

In 1904, Richard Semon introduced the term “engram” to describe the neural substrate responsible for (or at least important in) storing and recalling memories (i.e., a memory trace). The recent introduction of a vast array of powerful new tools to probe and manipulate memory function at the cell and neuronal circuit level has spurred an explosion of interest in studying the engram. However, the present “engram renaissance” was not borne in isolation but rather builds on a long tradition of memory research. We believe it is important to acknowledge the debts our current generation of scientists owes to those scientists …


Estimating Costs And Benefits Associated With Evidence-Based Prevention: Four Case Studies Based On The Fourth R Program, Claire Crooks, Jennifer Zwicker, Lana Wells, Ray Hughes, Amanda Langlois, J.C. Herb Emery May 2017

Estimating Costs And Benefits Associated With Evidence-Based Prevention: Four Case Studies Based On The Fourth R Program, Claire Crooks, Jennifer Zwicker, Lana Wells, Ray Hughes, Amanda Langlois, J.C. Herb Emery

Journal Articles

Teen violence in dating and peer relationships has huge costs to society in numerous areas including health care, social services, the workforce and the justice system. Physical, psychological, and sexual abuse have long-lasting ramifications for the perpetrators as well as the victims, and for the families involved on both sides of that equation. An effective violence prevention program that is part of a school’s curriculum is beneficial not only for teaching teenagers what is appropriate behaviour in a relationship, but also for helping them break the cycle of violence which may have begun at home with their own maltreatment as …


Sensory Processing In Autism Spectrum Disorders And Fragile X Syndrome-From The Clinic To Animal Models., D Sinclair, B Oranje, K A Razak, S J Siegel, S Schmid May 2017

Sensory Processing In Autism Spectrum Disorders And Fragile X Syndrome-From The Clinic To Animal Models., D Sinclair, B Oranje, K A Razak, S J Siegel, S Schmid

Brain and Mind Institute Researchers' Publications

Brains are constantly flooded with sensory information that needs to be filtered at the pre-attentional level and integrated into endogenous activity in order to allow for detection of salient information and an appropriate behavioral response. People with Autism Spectrum Disorder (ASD) or Fragile X Syndrome (FXS) are often over- or under-reactive to stimulation, leading to a wide range of behavioral symptoms. This altered sensitivity may be caused by disrupted sensory processing, signal integration and/or gating, and is often being neglected. Here, we review translational experimental approaches that are used to investigate sensory processing in humans with ASD and FXS, and …


Online Neural Monitoring Of Statistical Learning., Laura J Batterink, Ken A Paller May 2017

Online Neural Monitoring Of Statistical Learning., Laura J Batterink, Ken A Paller

Brain and Mind Institute Researchers' Publications

The extraction of patterns in the environment plays a critical role in many types of human learning, from motor skills to language acquisition. This process is known as statistical learning. Here we propose that statistical learning has two dissociable components: (1) perceptual binding of individual stimulus units into integrated composites and (2) storing those integrated representations for later use. Statistical learning is typically assessed using post-learning tasks, such that the two components are conflated. Our goal was to characterize the online perceptual component of statistical learning. Participants were exposed to a structured stream of repeating trisyllabic nonsense words and a …


Estimating Costs And Benefits Associated With Evidence-Based Violence Prevention: Four Case Studies Based On The Fourth R Program, Claire Crooks, Jennifer Zwicker, Lana Wells, Ray Hughes, Amanda Langlois, J.C. Herbert Emery May 2017

Estimating Costs And Benefits Associated With Evidence-Based Violence Prevention: Four Case Studies Based On The Fourth R Program, Claire Crooks, Jennifer Zwicker, Lana Wells, Ray Hughes, Amanda Langlois, J.C. Herbert Emery

Education Publications

Teen violence in dating and peer relationships has huge costs to society in numerous areas including health care, social services, the workforce and the justice system. Physical, psychological, and sexual abuse have long-lasting ramifications for the perpetrators as well as the victims, and for the families involved on both sides of that equation. An effective violence prevention program that is part of a school’s curriculum is beneficial not only for teaching teenagers what is appropriate behaviour in a relationship, but also for helping them break the cycle of violence which may have begun at home with their own maltreatment as …


Bk Channels Mediate Synaptic Plasticity Underlying Habituation In Rats., Tariq Zaman, Cleusa De Oliveira, Mahabba Smoka, Chakravarthi Narla, Michael O Poulter, Susanne Schmid Apr 2017

Bk Channels Mediate Synaptic Plasticity Underlying Habituation In Rats., Tariq Zaman, Cleusa De Oliveira, Mahabba Smoka, Chakravarthi Narla, Michael O Poulter, Susanne Schmid

Brain and Mind Institute Researchers' Publications

Habituation is a basic form of implicit learning and represents a sensory filter that is disrupted in autism, schizophrenia, and several other mental disorders. Despite extensive research in the past decades on habituation of startle and other escape responses, the underlying neural mechanisms are still not fully understood. There is evidence from previous studies indicating that BK channels might play a critical role in habituation. We here used a wide array of approaches to test this hypothesis. We show that BK channel activation and subsequent phosphorylation of these channels are essential for synaptic depression presumably underlying startle habituation in rats, …