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Articles 1591 - 1620 of 1943

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Differentially Expressed Genes In The Mutualistic Neotyphodium Coenophialum-Tall Fescue Interaction, Linda Joy Johnson Dec 2002

Differentially Expressed Genes In The Mutualistic Neotyphodium Coenophialum-Tall Fescue Interaction, Linda Joy Johnson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Tall fescue (Lolium arundinaceum), an agronomically important forage grass, is typically associated with a mutualistic asexual fungus Neotyphodium coenophialum. Endophytic fungal growth is confined to the intercellular spaces of the plant and induces no symptoms. The endophyte partner enhances its host's fitness by improving nutrient acquisition as well as by providing protection from various abiotic and biotic stresses. However, grass-endophyte partnerships are detrimental to grazing livestock, due to the production of an array of fungal alkaloids. To investigate this interaction at the molecular level, suppressive subtractive hybridization was used to identify differentially expressed genes from the symbiosis. In total, twenty-nine …

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Impact Of Early Childhood Perceptions And Experiences On Oral Health Practices In Later Life, Johnna Marie Guzzi Dec 2002

Impact Of Early Childhood Perceptions And Experiences On Oral Health Practices In Later Life, Johnna Marie Guzzi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Older adults are at a higher risk for numerous oral and systemic diseases. Oral conditions experienced by the elderly are believed to be cumulative. The purpose of this study was to determine if a relationship exists between early childhood dental care practices/experiences and perceived oral health needs of persons 60 years of age and older who are participants of three West Virginia facilities for the elderly (N = 90). Individuals were interviewed utilizing a two-part 21-item survey. Data analyses, including analysis of variance and tests of chi square, were conducted using the JMP program. Although individuals felt dental health was …

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Opportunities And Occupations In Animal And Veterinary Sciences Based On The Current Careers Of West Virginia University Alumni, Stacey Michelle Hawkins Dec 2002

Opportunities And Occupations In Animal And Veterinary Sciences Based On The Current Careers Of West Virginia University Alumni, Stacey Michelle Hawkins

Graduate Theses, Dissertations, and Problem Reports (ETD)

The primary purpose of this study was to examine the career opportunities for graduates completing a Bachelor of Science degree in Animal and Veterinary Sciences at West Virginia University as measured by the first and current careers of alumni. The target population consisted of all alumni that graduated between the years 1991 and 2001. Over 61.6% of the West Virginia University Animal and Veterinary Science graduates were satisfied with both their first career selection as well as their current career. After graduating with a Bachelor of Science degree two-thirds of the graduates decided to pursue a post-graduate degree. Professional careers, …

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Effect Of Dietary Protein On Plasma Uric Acid, Body Weight, And Oxidative Stress In Broilers, Maribel Machin Aug 2002

Effect Of Dietary Protein On Plasma Uric Acid, Body Weight, And Oxidative Stress In Broilers, Maribel Machin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Uric acid is an important antioxidant due to its role as a free radical scavenger, and methods to elevate its plasma concentration may be important in animal health. In a preliminary study, the effect of dietary protein on plasma uric acid (PUA) was determined in 3-wk-old chicks. Twenty-four broiler chicks were randomly assigned to 4 diets: low protein (LP) containing 10% casein, medium protein (MP) containing 20% casein, high protein (HP) containing 45% casein and a commercial diet (COD) for 2-wks. PUA concentration increased in chicks fed HP diet and declined in chicks fed LP. In the principal study, PUA …

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Organic Carbon And Fertility Of Forest Soils On The Allegheny Plateau Of West Virginia, Anthony Blaine Jenkins Aug 2002

Organic Carbon And Fertility Of Forest Soils On The Allegheny Plateau Of West Virginia, Anthony Blaine Jenkins

Graduate Theses, Dissertations, and Problem Reports (ETD)

Soil series occurring above 1020 m in elevation in the Monongahela National Forest in West Virginia were sampled and analyzed for soil organic and soil microbial biomass carbon as well as various fertility parameters. Additionally, vegetative biomass estimates were made at the sampling sites. The soil series sampled (established and tentative) are frigid, well and moderately-well drained inceptisols and spodosols, covered by northern hardwood or spuce-dominated forests. The purpose of the work was to document soil organic carbon (SOC), vegetative organic carbon (VOC), and soil microbial biomass carbon (SMBC) of selected horizons, and nutrient stock ranges for these extensive series, …

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Development Of The Induced Gonadotropin Surge Mechanism In The Prepubertal Heifer, Timothy David Maze Aug 2002

Development Of The Induced Gonadotropin Surge Mechanism In The Prepubertal Heifer, Timothy David Maze

Graduate Theses, Dissertations, and Problem Reports (ETD)

A longtitudinal study was performed in prepubertal heifer calves to determine when the individual components of the hypothalamic-pituitary-ovarian axis were capable of functioning. In study 1, the hypothalamus and anterior pituitary of prepubertal dairy heifers were challenged with exogenous hormones (estradiol and GnRH, respectively) to determine at what age gonadotropin surges could be induced. Two-, four-, six-, and eight-month-old heifer calves were challenged with GnRH or estradiol. Blood was sampled from the jugular vein every 15 minutes for 6 hours or hourly for 30 hours, for the two treatments, respectively. Heifers in each age group released LH in response to …

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Modeling Of Soil Phosphorus Sorption And Control Of Phosphorus Pollution With Acid Mine Drainage Floc, Bharpoor Singh Sekhon Aug 2002

Modeling Of Soil Phosphorus Sorption And Control Of Phosphorus Pollution With Acid Mine Drainage Floc, Bharpoor Singh Sekhon

Graduate Theses, Dissertations, and Problem Reports (ETD)

The study was conducted to investigate and model phosphorus sorption in soils and to study the effectiveness of acid mine drainage (AMD) floc in controlling phosphorus (P) loss to surface runoff from soils. Phosphorus sorption capacity of surface and subsurface horizons of four benchmark soil series - Berks, Huntington, Lindside, and Monongahela - of West Virginia was measured. The soils of these four series were loaded with increasing amounts of P up to 60% of their P retention capacity. Though amount of P released to the solution increased with increase in degree of P saturation, most of the soils did …

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Interaction Between Positive And Negative Effectors Of Embryonic And Postnatal Muscle Growth In The Chicken And The Mouse, Scott Allen Gahr Aug 2002

Interaction Between Positive And Negative Effectors Of Embryonic And Postnatal Muscle Growth In The Chicken And The Mouse, Scott Allen Gahr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Myostatin, belonging to the TGF-beta family, negatively regulates skeletal muscle growth. The current study was conducted to assess the efficacy of in ovo administration of exogenous myostatin antagonist (MA) to enhance skeletal muscle growth and improve feed efficiency of broilers.;Growth hormone secretion is under the control of a pair of hypothalamic factors, growth hormone releasing hormone and somatostatin. The growth hormone secretagogue receptor (GHSR) and its endogenous ligand represent a novel third mechanism regulating the release of growth hormone. Early chicken embryonic development, prior to day 14, has been proposed to be independent of GH. However, recent evidence shows that …

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Stress Response Genes In The Human Proximal Tubules, Doyeob Kim Aug 2002

Stress Response Genes In The Human Proximal Tubules, Doyeob Kim

Graduate Theses, Dissertations, and Problem Reports (ETD)

The heat shock proteins (hsps) are believed to provide protection against a variety of insults such as elevated temperature, heavy metals and chemical agents. The goal of this study was to determine if the immortalized HK-2 human proximal tubule cell line could provide a model system to study the stress response of the proximal tubule cell. Heat stress, elevated temperature at 42.5°C for 1 hr, caused a marked increase only in hsp 70 mRNA and protein, but not that of hsp 27 or hsp 60 mRNA and protein. Similar results were obtained when the cells were subjected to 100 muM …

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Effect Of Peptidoglycan-Polysaccharide Complex On Reproductive Efficiency And Mastitis In Sheep, Ida Holaskova Aug 2002

Effect Of Peptidoglycan-Polysaccharide Complex On Reproductive Efficiency And Mastitis In Sheep, Ida Holaskova

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bacterial infections associated with mastitis reduce pregnancies in cattle. Effects on pregnancy and incidence of mastitis in sheep were investigated after immunization with peptidoglycan-polysaccharide (PG-PS) and killed cells from Strep. pyogenes. Rambouillet (n = 100) and mixed breed (n = 18) ewe lambs were immunized (∼d42 and 22 before breeding) with PG-PS (30mugPG/kg/bw) or killed cells or were not immunized (Control, n = 117). IgG antibodies were detected by ELISA. Ewes were bred at synchronized estrus. All immunized and half of non-immunized ewes were challenged with PG-PS (60mugPG/kg/bw) d5 after breeding. Although proportion of ewes pregnant at d42 did not …

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Relative Abundance, Temporal Distribution, And Functional Feeding Groups Of Aquatic Insects In Two First-Order Southwestern Pennsylvania Streams, Judith S. Steinberg Aug 2002

Relative Abundance, Temporal Distribution, And Functional Feeding Groups Of Aquatic Insects In Two First-Order Southwestern Pennsylvania Streams, Judith S. Steinberg

Graduate Theses, Dissertations, and Problem Reports (ETD)

Two first to second order streams (Kent Run and Munnell Hollow) at Ryerson Station State Park, Greene County, Pennsylvania, were compared as to water parameters (dissolved oxygen, hardness, temperature, pH, and current velocity), species diversity, and abundance of both immature and adult insects. Samples were taken biweekly for one year from May, 1999 through April, 2000 for a total of 26 sampling periods. Data were analyzed using a repeated measures ANOVA. Kent Run had lower dissolved oxygen, higher pH and hardness, lower temperatures, and higher current velocity. A total of 137 taxa were collected at both streams. Of the total …

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Comparison Of Buffered Grazing Systems For Beef Cattle, Charles R. Wolfe Iii May 2002

Comparison Of Buffered Grazing Systems For Beef Cattle, Charles R. Wolfe Iii

Graduate Theses, Dissertations, and Problem Reports (ETD)

To evaluate the productivity of a rotational versus continuous grazing system for beef production within a buffer grazing system, thirty crossbred beef cows and their calves were randomly assigned to one of two grazing systems replicated twice over three years of the experiment. Each replication of the rotational system was stocked with 8 cow/calf pairs while the continuous system was stocked with 7 cow/calf pairs. The grazing season was divided into 3 periods to aid in analysis. Period 1 was further divided into grazing cycles consisting of 4 weeks each. Pasture growth during cycle I was found to be higher …

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Herbal Supplement Education In Dental Hygiene Curricula, Lisa Elena Lisauckis May 2002

Herbal Supplement Education In Dental Hygiene Curricula, Lisa Elena Lisauckis

Graduate Theses, Dissertations, and Problem Reports (ETD)

While there is evidence in the literature of herbal supplement education in other disciplines, inclusion in dental hygiene curricula is not reported. The purpose of this study was to assess the prevalence and extent of herbal supplement education in the 256 accredited dental hygiene programs in the United States. A survey was sent to program directors. Data analyses, including frequencies, cumulative frequencies, percentages, analyses of variance, and test of Chi Square were conducted using JMP program. Surveys revealed 63% of respondents (n = 160) included herbal supplement education and primarily incorporated it in the pharmacology course (67%). Statistically significant differences …

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Sensitivity Of State Aid Allocation To Measures Of Needs And Resources In Local Governments, Adam Dale Baus May 2002

Sensitivity Of State Aid Allocation To Measures Of Needs And Resources In Local Governments, Adam Dale Baus

Graduate Theses, Dissertations, and Problem Reports (ETD)

This analysis examines the sensitivity of state intergovernmental aid, per capita, to measures of resources, infrastructure, social services, social problems and demographics in Northern and Southern local governments in 1982 and 1992. Time-periods chosen are based on the potential for domestic policies born through new federalism to harm local governments through lesser amounts of available state aid. North and South are compared to account for possible regional differences. Regardless of region and time however, redistribution efforts to local governments with higher levels of need and lower levels of resources are not particularly good. Redistribution tendencies present in 1982 declined by …

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Comparison Of Broiler Breeder Production And Fertility In A Colony Cage System With Two Different Floors Versus A Slat-Floor System, Joseph Wayne Massey May 2002

Comparison Of Broiler Breeder Production And Fertility In A Colony Cage System With Two Different Floors Versus A Slat-Floor System, Joseph Wayne Massey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Two separate trials were conducted to compare egg production, egg weight, shell thickness, albumin height, fertility, and mortality of naturally mated broiler breeders maintained on either a slat and litter floor or in two tiered colony cages. In the first trial there was no difference (P > 0.05) in egg production between the two treatments. There was also no significant difference in hen mortality. Higher (P < 0.05) egg shell quality, albumin height, and shell thickness were observed in the cage maintained hens. Lower fertility (P < 0.05) was observed in the cage maintained hens. In the second trial production parameters were compared in naturally mated broiler breeders maintained on slat and litter floor, in colony cages on the original slats, and in colony cages on a modified slats. The modified slats were constructed from plastic and had a two piece design which produced a slight cushioning on the top of the slats. Egg production and mortality were not different (P > 0.05) among the three treatments. Eggshell thickness, albumin height, and shell thickness were lower (P > 0.05) in the litter and slat floor but not between the two cage treatments (P > 0.05). Fertility was higher (P …

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Influence Of Mass Of Ruminal Contents On Voluntary Intake And Digesta Passage Of A Concentrate And A Forage Diet, Marcela Ana Whetsell May 2002

Influence Of Mass Of Ruminal Contents On Voluntary Intake And Digesta Passage Of A Concentrate And A Forage Diet, Marcela Ana Whetsell

Graduate Theses, Dissertations, and Problem Reports (ETD)

To evaluate the influence of mass of rumen contents on voluntary intake and rumen function, five ruminally cannulated steers (500 kg) were fed a hay diet ad libitum in a 5 x 5 Latin square experiment. Mass of ruminal contents was altered by adding varying weights of modified tennis balls to the rumen before the initiation of each experimental period. Treatments consisted of 50 balls with a specific gravity (SG) of either 1.0, 1.1, 1.2, 1.3 or 1.4 and the total weight of the balls was 7.45 kg, 8.50 kg; 9.25 kg, 10.55; and 11.55 kg, respectively. Daily DMI was …

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Effect Of Increased Energy In A Restricted Diet On Bone Mineral Composition And Breaking Load Of Young Rat Tibias, Marcia Ann Romanchak May 2002

Effect Of Increased Energy In A Restricted Diet On Bone Mineral Composition And Breaking Load Of Young Rat Tibias, Marcia Ann Romanchak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Osteoporosis is a major health problem in the United States and those that are on energy restricted diets such as anorectic subjects. Thirty Wistar strain, young male rats were fed diets with varying quantities of fat for a period of four weeks (energy intake 67--75% of requirement). The rat tibias' physical properties were measured. Bone mineral composition testing was conducted for calcium, magnesium, and phosphorus, on the tibia shaft. There were no significant differences among the parameters of length, diameter, volume, density, bone bending (elasticity), fracture load, and minerals between experimental diets. There was a negative association between bending and …

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Retention Of Early Pregnancy And Its Relationship To Serum Progesterone In Dairy Cattle, Melanie J. Starbuck May 2002

Retention Of Early Pregnancy And Its Relationship To Serum Progesterone In Dairy Cattle, Melanie J. Starbuck

Graduate Theses, Dissertations, and Problem Reports (ETD)

Factors affecting pregnancy maintenance between 28 and 67 days of gestation were studied in dairy cows (N = 211). Beginning on day 28 to 37 post breeding, cows were examined by ultrasonography for a viable pregnancy. Pregnant cows were re-examined for pregnancy losses during the late embryonic (≤day 45) and early fetal stages up to day 67. Overall pregnancy loss was 11%, mostly occurring before day 45. Cows with two corpora lutea maintained fewer pregnancies than cows with one corpus luteum. Pregnancy retention was less when concentrations of progesterone were low during days 28 to 37. The embryo apparently died …

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Relationship Between Maternal Prenatal Vitamin Use And Infant Iron Status, Jennie Pringle Wilkins May 2002

Relationship Between Maternal Prenatal Vitamin Use And Infant Iron Status, Jennie Pringle Wilkins

Graduate Theses, Dissertations, and Problem Reports (ETD)

Subjects were fifty-six women and their infants who were between the ages of six months and twenty-four months. They were clients of Special Supplemental Nutrition Program for Women Infants and Children (WIC) clinics. The WIC clinics were in the West Virginia counties of Ritchie, Gilmer, Calhoun, Braxton, Mason, Jackson, Pleasants, and Greenbrier where the anemia rates were greater than 10%.;Information concerning WIC participation, prenatal vitamin use, history of breast feeding, infant birth weight, and pre-term delivery were obtained through questionnaires. Infants' serum ferritin level was obtained through venous blood and analyzed.;This ex post facto study found no significant result in …

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Combined Effects Of Water Chemistry, Canopy Cover, And Stream Size On Benthic Macroinvertebrates Along A Central Appalachian Stream Continuum, Jesse Adam Bopp May 2002

Combined Effects Of Water Chemistry, Canopy Cover, And Stream Size On Benthic Macroinvertebrates Along A Central Appalachian Stream Continuum, Jesse Adam Bopp

Graduate Theses, Dissertations, and Problem Reports (ETD)

I sampled benthic macroinvertebrates along a 25.2 km stream continuum in the Central Appalachian Mountains of West Virginia from May---October 2000. Six components of macroinvertebrate community structure and function were measured: density, biomass, richness, community taxa similarity, feeding group composition, and metric composition. I quantified these components to determine if localized variation in alkalinity and canopy cover would modify stream continuum predictions. Localized variation in alkalinity and canopy cover significantly affected macroinvertebrate structure and function and modified stream continuum predictions. Results indicated that alkalinity was the primary determinant of macroinvertebrate structure and function, and that the effects of canopy cover …

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Microbial Ecology Of Freshly Sawn Yellow-Poplar Lumber ( Liriodendron Tulipifera L.) In Two Seasons, Mark Ryan Mikluscak May 2002

Microbial Ecology Of Freshly Sawn Yellow-Poplar Lumber ( Liriodendron Tulipifera L.) In Two Seasons, Mark Ryan Mikluscak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Each year, the forest products industry sustains considerable product loss due to a reduction in market value of lumber brought about by microbial discoloration. The current practice of treating green lumber with chemical biocides to protect it from discoloration, although successful, is a potential hazard to both the environment and human life. One potential alternative to chemical biocides is biological control. The most recent success in the field of biological control has been achieved in the agricultural industry by first studying the microbial ecology of the substrate in which the biologically based preservative is to be used. Literature on microbial …

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Inhibition Of The Splicing Of Glucose-6-Phosphate Dehydrogenase Precursor Mrna By Polyunsaturated Fatty Acids, Huimin Tao, Wioletta Szeszel-Fedorowicz, Batoul Amir-Ahmady, Matthew A. Gibson, Laura P. Stabile, Lisa M. Salati Jan 2002

Inhibition Of The Splicing Of Glucose-6-Phosphate Dehydrogenase Precursor Mrna By Polyunsaturated Fatty Acids, Huimin Tao, Wioletta Szeszel-Fedorowicz, Batoul Amir-Ahmady, Matthew A. Gibson, Laura P. Stabile, Lisa M. Salati

Faculty & Staff Scholarship

No abstract provided.

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Hay Quality Vs Hay Quantity, Edward Barrow Rayburn Jan 2002

Hay Quality Vs Hay Quantity, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

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Proper Handling And Curing Of Hay, Edward Barrow Rayburn Jan 2002

Proper Handling And Curing Of Hay, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

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Communication Of Position In Current National Primetime Brand Advertising: A Content Analysis., Chad Matthew Mezera Jan 2002

Communication Of Position In Current National Primetime Brand Advertising: A Content Analysis., Chad Matthew Mezera

Graduate Theses, Dissertations, and Problem Reports (ETD)

Study examines communication of brand position in current national brand advertising on the four network stations during primetime programming. Content analysis of a random sample of advertising executions was performed on the premise that evaluation of said executions should be performed on the basis of cues provided by the execution to the viewer. Coded results are provided and analyzed. Brand position, as applied to communication in television commercials, is defined and explored.

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The Prevalence Of Heart-Healthy Menu Items In Restaurants Of West Virginia., Jenni Lin Jones Jan 2002

The Prevalence Of Heart-Healthy Menu Items In Restaurants Of West Virginia., Jenni Lin Jones

Graduate Theses, Dissertations, and Problem Reports (ETD)

Heart disease and obesity are concurring health problems in the state of West Virginia (WV). With obesity levels rising and heart disease remaining the number one cause of mortality in WV, the need for a lifestyle change is prominent. The West Virginia Restaurant Survey attempted to determine the availability of heart-healthy food items that restaurants offer and how the items are promoted in order to determine the need for intervention programs that support heart-healthy food choices. Menus were analyzed from restaurants located in the top ten most populated cities in WV. Gas stations, mini-marts, and bars without restaurants were excluded. …

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Development Of Antibiotic Resistance Due To Chromosomal Mutation Caused By Ah26 Endodontic Sealer., Jason J. Hales Jan 2002

Development Of Antibiotic Resistance Due To Chromosomal Mutation Caused By Ah26 Endodontic Sealer., Jason J. Hales

Graduate Theses, Dissertations, and Problem Reports (ETD)

The endodontic resin sealer AH26® has been shown in multiple studies to have mutagenic potential. A unique test designed to identify phenotypic change in antibiotic resistance due to chromosomal mutation was described and performed. This test, modeled after the Ames test, used the Salmonella typhimurium (TA100) as the test organism. The test was divided into four phases. 1. Mutation Phase 2. Protein Expression Phase 3. Plate Incorporation 4. Evaluation of Antibiotic Resistance - changes in MIC values to ciprofloxacin, tetracycline & erythromycin identified with Etest®. The AH26® demonstrated a log-fold increase in mutant rate compared to the spontaneous mutant rate. …

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Professional Development School: Perceptions Of Student Learning, Success, Respect And Parent Participation From A Rural High School., Sarah M. Bennett-Harper Jan 2002

Professional Development School: Perceptions Of Student Learning, Success, Respect And Parent Participation From A Rural High School., Sarah M. Bennett-Harper

Graduate Theses, Dissertations, and Problem Reports (ETD)

A broad literature has presented that there is a direct connection between parent participation in a child’s education and learning. However, very little literature exists on high school Professional Development School (PDS) students and their parent’s participation in their learning. This thesis focused on student and parent perceptions of student learning, respect and success, as well as, how parents were involved in their child’s education. This study surveyed 9th - 11th grade students and their parents at Grafton High School (GHS), a PDS, located in Grafton, West Virginia, during the spring of 1997. Responses to parent and student questionnaire items …

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The Efficacy Of A Media Literacy Program For The Prevention And Treatment Of Eating Disturbances: Implications For The Continuum Model Of Eating Disorders., Janelle Wilder Coughlin Jan 2002

The Efficacy Of A Media Literacy Program For The Prevention And Treatment Of Eating Disturbances: Implications For The Continuum Model Of Eating Disorders., Janelle Wilder Coughlin

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of the current study was to determine whether a two-session media literacy program, A.R.M.E.D. (Acknowledging and Rejecting the Media's Influence on Eating and Body Image Disturbances), was an effective intervention for individuals who fell at various points on the eating disorder continuum. Ninety-three female college students participated in the study, with 46 experimental participants attending A.R.M.E.D and 47 participants serving as a control group. Between-subjects analyses did not reveal differences between the experimental and control group on each of the seven dependent variables. Within-subjects repeated measures analyses did, however, reveal that women who attended A.R.M.E.D. significantly reduced their …

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Progression Of Chronic Renal Disease In Several Animal Models: Possible Role Of Decreased Renal Nitric Oxide Production As A Primary Causative Factor., Aaron D. Erdely Jan 2002

Progression Of Chronic Renal Disease In Several Animal Models: Possible Role Of Decreased Renal Nitric Oxide Production As A Primary Causative Factor., Aaron D. Erdely

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chronic renal disease is the progressive loss of renal function that can lead to end-stage renal disease. Recent studies from our laboratory have shown decreased total NO production in patients with renal disease. Animal models have shown decreased total and renal NO production and chronic NOS inhibition in otherwise healthy rats causes renal injury. The overall objective in this set of studies was to investigate intrarenal NO production in various models of CRD and determine if NO deficiency parallels, and perhaps causes renal injury. In the first study, we report that normal male SD rats exhibit age-dependent declines in total …

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