Digital Commons Network^™

Therapeutic Approaches To Recovery In West Virginia, Rachel A. Wattick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Substance use disorder (SUD) is a prevalent problem in the United States, with 19.7 million Americans aged 12 and older battling an SUD in 2017. Multiple factors influence the risk that someone will develop an SUD, including family history, childhood trauma, community factors, and poverty. West Virginia has the highest rate of overdose deaths in the nation, and individuals in WV are at high risk of SUD due to the aforementioned risk factors. There are a variety of treatment options available to someone with an SUD. These include outpatient or inpatient treatment, detoxification, therapeutic communities, and collegiate recovery programs. Despite …

Breast Cancer Associated Muscle Fatigue: Novel Targets To Improve Survival And Quality Of Life, Hannah Elizabeth Wilson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Women diagnosed with breast cancer (BC) currently represent the largest group of cancer survivors in the United States, accounting for over 20% of those living after a cancer diagnosis. Most BC survivors report an unusual degree of fatigue, which can present prior to diagnosis and continue for many years after treatment cessation. Recent studies show that deficits in muscle function predict shorter survival in cancer, perhaps due to the fact that fatigue is known to reduce a patient’s tolerance to anti-cancer therapies. Therefore, improving muscle function in BC patients has the potential to improve both quality of life and survival …

Exploring The User Experiences Of A Bird Id Mobile App Among College Students In Western India, Jayvijay V. Raol

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study explores user experiences of a sample of college age young adults from western India, with a bird ID mobile app. Mobile apps provide an attractive and interactive access to information and their reach and versatility can often bypass challenges of poor infrastructure and lack of access to sources for information. Studies that examine the influence of mobile apps on users’ knowledge and awareness are still in their infancy. Mobile phones and mobile applications have become increasingly prevalent in the educational setting, not only as technology for instructional delivery, but also as a means of improving user experience when …

Early Black Poetry, Social Justice, And Black Children: Receptions Of Child Activism In African American Literary History, Tabitha Lashay Joy Lowery

Graduate Theses, Dissertations, and Problem Reports (ETD)

In spite of the substantial amount of critical work that has been produced on the recovery of early African American literature in the last few decades, our representations of black authors are still limited. Current studies of early African American poets privilege the identification of African American literature with resistance to slavery. This identification has persisted and has made the field one-dimensional. My dissertation provides reception histories of four early black poets—Phillis Wheatley, George Moses Horton, Frances Harper, and Paul Laurence Dunbar—to argue for and present an expansive understanding of African American literature. A thorough examination of these authors’ circulation …

Parametric Optimization Of Visible Wavelength Gold Lattice Geometries For Improved Plasmon-Enhanced Fluorescence Spectroscopy, Casey A. Norville

Graduate Theses, Dissertations, and Problem Reports (ETD)

The exploitation of spectro-plasmonics will allow for innovations in optical instrumentation development and the realization of more efficient optical biodetection components. Biosensors have been shown to improve the overall quality of life through real-time detection of various antibody-antigen reactions, biomarkers, infectious diseases, pathogens, toxins, viruses, etc. has led to increased interest in the research and development of these devices. Further advancements in modern biosensor development will be realized through novel electrochemical, electromechanical, bioelectrical, and/or optical transduction methods aimed at reducing the size, cost, and limit of detection (LOD) of these sensor systems. One such method of optical transduction involves the …

Spatio-Temporal Analysis Of Crime Incidents For Forensic Investigation, Jamie Spencer Spaulding

Graduate Theses, Dissertations, and Problem Reports (ETD)

Crime analysis and mapping has been routinely employed to gather intelligence which informs security efforts and forensic investigations. Traditionally, geographic information systems in the form of third-party mapping applications are used for analysis of crime data but are often expensive and lack flexibility, transparency, or efficiency in uncovering associations and relationships in crime. Each crime incident and article of evidence within that incident has an associated spatial and temporal component which may yield significant and relevant information to the case. Wide variations exist in the techniques that departments use and commonly spatial and temporal components of crime are evaluated independently, …

Low-Cost Skewed Redundant Imu Configuration For State-Space Recovery In A Saturated Environment, Levi S. Hubbard

Graduate Theses, Dissertations, and Problem Reports (ETD)

Low-cost sensors for state space determination can be used successfully for ground vehicles, robots, unmanned aerial vehicles, and Internet-of-Things applications. When a high fidelity Inertial Measurement Unit (IMU) cannot be obtained for state space determination, low-cost sensors can be used to satisfactory standards, despite their limitations in capabilities, by using various implementation techniques. The research group was experimentally investigating state space information of an unstable flying vehicle for motion simulation validation. The high fidelity motion capture system would intermittently lose track of the flight vehicle which lost critical flight data.

The goal was to determine the potential of low-cost off-the-shelf …

Pulmonary Immune Responses To Respirable Elongate Mineral Particles Of Asbestiform And Non-Asbestiform Morphologies, Timur Khaliullin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Inhalation exposure to asbestiform elongate mineral particles (EMPs) may cause pulmonary fibrosis, lung and pleural cancer. At the same time, epidemiological evidence for non-asbestiform EMP pathogenicity is scarce, with little if any risk of cancer, but consistent findings of pneumoconiosis and increased mortality. Globally, conditions caused by asbestos exposures contribute most to the occupational cancer burden and are responsible for the increasing mortality for occupational respiratory diseases. Immunological components of the fiber-induced lesions are extremely understudied, partly due to the lack of comparable test articles. In this study I utilized respirable preparations of asbestiform and non-asbestiform riebeckite and tremolite to …

A Machine Learning Approach To Estimate The Annihilation Photon Interactions Inside The Scintillator Of A Pet Scanner, Sai Akhil Bharthavarapu

Graduate Theses, Dissertations, and Problem Reports (ETD)

Biochemical processes are chemical processes that occur in living organisms. They can be studied with nuclear medicine through the help of radioactive tracers. Based on the radioisotope used, the photons that are emitted from the body tissue are either detected by single-photon emission computed tomography (SPECT) or by positron emission tomography (PET) scanners. SPECT uses gamma rays as tracer but gives a weaker contrast and spatial resolution compared to a PET scanner which uses positrons as tracer. PET scans show the metabolic changes occurring at the cellular level in an organ or a tissue. This detection is important because diseases …

Understanding The Host Immune Response Against Pseudomonas Aeruginosa To Develop Novel Therapeutics And Vaccines, Emel Sen Kilic

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium that causes a broad range of acute and chronic infections. The high adaptability and emergence of multidrug-resistant strains of this bacterium pose a significant threat to human health. Particularly, pneumonia caused by this pathogen is associated with high morbidity and mortality in immunocompromised patients. To prevent these infections, we aimed to develop novel vaccine strategies by characterizing the host immune response against P. aeruginosa. During respiratory infections, P. aeruginosa first contacts with epithelial cells along the respiratory tract. Using RNA-sequencing, we were able to characterize transcriptional changes of the epithelial cells in …

Chlordiazepoxide Increases Risky Choice, Devin Andrew Galdieri

Graduate Theses, Dissertations, and Problem Reports (ETD)

Probability discounting is a measure of risky choice that is correlated with maladaptive behavior and psychological disorders. Benzodiazepines are a class of drug on which relatively little risky-choice research has been conducted, particularly under conditions of chronic drug exposure. Chlordiazepoxide, a standard benzodiazepine, was administered to rats that had been trained to respond on a risky-choice task in which a choice was available between a single food pellet with 100% certainty or three food pellets with probabilities of delivery that decreased across each experimental session. During baseline, responding was sensitive to the programmed contingencies and larger-reinforcer choice decreased as the …

Microbial Responses To Unconventional Oil And Gas Development May Alter Ecosystem Function In Headwater Streams, Rachel Michaels

Graduate Theses, Dissertations, and Problem Reports (ETD)

The demand for natural gas, and the need for efficient extraction, has led to the development of unconventional oil and natural gas (UOG) techniques. Due to the novelty of UOG, the potential impacts to freshwater ecosystems are not fully understood. We used a dual pronged approach to study the effects of UOG development on microbial biodiversity and function via a laboratory microcosm experiment and a survey study of streams with and without UOG development within their watersheds. The laboratory microcosm study simulated stream contamination with produced water, a byproduct of UOG operation, using sediment collected from one high water-quality stream …

Sergei Prokofiev's Third Piano Sonata, Op. 28: Stylistic Analysis And Performance Suggestions, Youngju Lee

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sergei Prokofiev (1891-1953) was one of the greatest Russian pianists and composers of the twentieth century. He established his own musical style by combining classical form and modern compositional techniques. He composed a variety of piano music including nine piano sonatas. This paper is a study of the third piano sonata in A minor, op. 28.

Prokofiev’s music can be classified into three periods: a Russian Period, a Foreign Period, and a Soviet Period. It is possible to identify Prokofiev’s compositional styles by studying his piano sonatas because he composed piano sonatas during the entire course of his life. In …

Teacher As “Team Player”: An Early Career Teacher’S Refinement Of Critical Pedagogical Discourses, Keisha-Moraé Hopkins Kibler

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study centers on one early-career English language arts (ELA) teacher’s development of his critical pedagogical discourses (CPD) within the contextual discourses of collaboration and data informed instruction. These contextual discourses circulated assumptions of teaching and learning that are privileged by the political ideologies of the neo-liberal agenda, which can erode the democratic purposes of education. Data is drawn from an eight-month interpretive qualitative case study that included classroom observations and semi-structured interviews. The two research objectives for this study included: to come to understand the range of ways an early-career ELA teacher navigated the tensions between his belief and …

Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Traumatic brain injury (TBI) impacts millions worldwide and can cause lasting psychiatric symptoms. Chronic neuroinflammation is a characteristic of post-injury pathology and is positively associated with psychiatric conditions such as ADHD and bipolar disorder. Therefore, the current study sought to treat TBI-induced impulsivity and inattention using minocycline, an antibiotic with anti-inflammatory properties. Rats were trained on the five-choice serial reaction time task (5CSRT), a measure of motor impulsivity and attention. After behavior was stable on the 5CSRT, rats received either a bilateral frontal TBI or sham procedure. Minocycline was given at either 1 h post-injury or beginning at 8 weeks …

Haemonchus Contortus Antigen Identification And Use Of Tropomyosin In Ovine Vaccine Development, Brynnan P. Russ

Graduate Theses, Dissertations, and Problem Reports (ETD)

Globally, the small ruminant industry loses hundreds of millions of dollars due to parasitism by the gastrointestinal nematode Haemonchus contortus. This parasite feeds on blood in the host’s abomasum leading to disease including anemia, hypoproteinemia, lethargy, and death. There have been exhaustive efforts to manage this parasite including different management applications, anthelmintic treatment, and now integration of resistance genetics into a flock. Like antibiotics, overuse of anthelmintics has led to resistance of H. contortus to these drugs. Therefore, other methods of control are the main focuses of many research initiatives. St. Croix are a resistant breed of sheep that mount …

Factors Influencing Huntingtin Aggregation At Surfaces: Implications For Huntington’S Disease, Sharon E. Groover

Graduate Theses, Dissertations, and Problem Reports (ETD)

Huntington’s Disease (HD) is a genetic, neurodegenerative disease characterized by an abnormal polyglutamine (polyQ) expansion in the first exon of the huntingtin protein (htt). The polyQ domain facilitates aggregation and initiates the formation of a diverse collection of aggregate species, including fibrils, oligomers and annular aggregates. The first 17 amino acids of htt (Nt17) directly flank the polyQ domain and is a key factor in htt’s association to membranous structures. In addition to Nt17 being an amphipathic αhelix, it also promotes aggregation through self-association and contains numerous posttranslational modifications (PTMs) that can modulate toxicity and subcellular localization. For in depth …

Avian And Salamander Response To Young Forest Management In West Virginia, Eric L. Margenau

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation focuses on the effects of various young forest habitat management techniques on the avian and salamander community in West Virginia. Wildlife species associated with the nascent stage of forest succession are experiencing precipitous population declines throughout much of the eastern United States due to decreases in the amount of young forest area which have been brought on by changes in disturbance regimes over the past century. As a result, the need to find novel approaches for creating young forest habitats to sustain young forest wildlife populations is necessary. However, young forest habitat creation often negatively affects species that …

Cerebrovascular Dysfunction And Degeneration In Alzheimer’S Disease Pathophysiology, Dominic Dimitri Quintana

Graduate Theses, Dissertations, and Problem Reports (ETD)

Alzheimer’s disease (AD) is a terminal illness and the most common form of dementia, which disproportionately affects the aged population. The pathophysiology of AD is characterized by neurodegeneration that slowly progresses, affecting regions of the brain that are involved in learning, memory, language, and executive function. In patients with the disease, early symptoms include non-disruptive forgetfulness that evolves into the inability to form new memories and ultimately the loss of autonomy at late stages. Histopathological hallmarks in the brain from patients with AD is the presence of amyloid-β (Aβ)-plaques and neurofibrillary tangles (NFT) deposited in the parenchyma. Since the discovery …

Evaluation Of Object Attributes To Study Speed-Accuracy Trade-Off Of Gloves Using Iso 9241-411 Standard, Isha Gaut

Graduate Theses, Dissertations, and Problem Reports (ETD)

Selection of appropriate gloves plays an important role in the overall comfort and productivity of workers. Currently, there are no standards and/or guidelines available to systematically evaluate the glove performance based on speed-accuracy trade-off. The ISO 9241-411 standard which is based on Fitts’ Law has been extensively used in the literature to measure speed-accuracy trade-off in terms of throughput in the virtual environments. This study was aimed at developing guidelines for implementing ISO 9241-411 standard in the physical environment so that it can be used to estimate (and compare) throughputs of safety gloves. Specifically, the various physical attributes of objects …

Neuromechanical Tuning For Arm Motor Control, Russell Lee Hardesty Jr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Movement is a fundamental behavior that allows us to interact with the external world. Its importance to human health is most evident when it becomes impaired due to disease or injury. Physical and occupational rehabilitation remains the most common treatment for these types of disorders. Although therapeutic interventions may improve motor function, residual deficits are common for many pathologies, such as stroke. The development of novel therapeutics is dependent upon a better understanding of the underlying mechanisms that govern movement. Movement of the human body adheres to the principles of classic Newtonian mechanics. However, due to the inherent complexity of …

Green Completion As A Mitigation For Btex Exposure In Gas Flaring: Nigeria Case Study (Exposure Assessment And Cost Model), Akintunde S. Akinyemi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gas flaring is an essential part of the oil and gas industry safety and waste management procedures; however, it presents a potential exposure to BTEX compounds, a group of Non-Methane Volatile Organic Compounds (NMVOC), within up to a 10-mile radius of the flare point. The physical and the psychological cost of the journey to work, make employees live close to the workplace. This study examined the perceived exposure of oil and gas industry workers to possible carcinogenic emissions outside the workplace. It looked at the outcomes of the exposure to BTEX through gas flaring drawing on archival data and using …

Leaf Angle And Leaf Stomata Responses To Experimental Drought In Quercus Velutina And Acer Saccharum, Brittany Nichole Casey

Graduate Theses, Dissertations, and Problem Reports (ETD)

The possibility of increased severity and frequency of drought conditions, as a result of global climate variability, greatly complicates our ability to forecast future forest functions such as productivity and carbon sequestration. Assessing how tree species vary in their response to drought can aid in predicting the impact on forest ecosystems as a whole. Throughfall exclusion (TfE) experiments are potentially useful tools to simulate realistic drought conditions within intact forest ecosystems. We employed a TfE experiment during the 2018 growing season within the WV Land Trust’s Elizabeth’s Woods Nature Preserve, near Morgantown, WV, to assess the leaf angle and leaf …

Predictors Of Self-Control During Emerging Adulthood: The Roles Of Implicit Beliefs And Early Risk, Katy L. Delong

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study explored how early adverse experiences (i.e., low socioeconomic status, household chaos, attachment insecurity) and implicit beliefs about self-control (i.e., whether self-control is a limited or nonlimited resource) were associated with trait and momentary self-control in a sample of college students. As the first study to explore these factors together, individuals’ implicit beliefs were tested as a moderator and meditator of the association between early risk and self-control. Participants (N = 214) first completed a baseline survey with the main predictors and trait self-control, followed by one week of experience sampling to assess momentary self-control, or success resisting …

The Immunological Response To Chronic Stress In Obese Mice, Matthew Corey Parsley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Obesity and psychological stress are major risk factors for cardiovascular disease and have a positive correlation with vascular dysfunction. This functional deficit has been linked to a pro-inflammatory milieu, exacerbated by an upregulation of pro-inflammatory cytokines. Febuxostat, a xanthine oxidase inhibitor, has been shown to rescue vascular impairment in these models. The purpose of this study was to examine the individual and combined effects of obesity and chronic stress on neuroimmune cell populations, and assess if febuxostat is able mediate immune alterations.

Male mice (n=48) were assigned into either normal chow (lean) and high-fat diet (obese) groups. The lean animals …

Innovative Approaches To 3d Gis Modeling For Volumetric And Geoprocessing Applications In Subsurface Infrastructures In A Virtual Immersive Environment, Pragya Srivastava

Graduate Theses, Dissertations, and Problem Reports (ETD)

As subsurface features remain largely ‘out of sight, out of mind’, this has led to challenges when dealing with underground space and infrastructures and especially so for those working in GIS. Since subsurface infrastructure plays a major role in supporting the needs of modern society, groups such as city planners and utility companies and decision makers are looking for an ‘holistic’ approach where the sustainable use of underground space is as important as above ground space. For such planning and management, it is crucial to examine subsurface data in a form that is amenable to 3D mapping and that can …

Prescribing The Profession: Representations Of Medical Professionalization Debates In American Literary Forms, 1830-1940, Jeffrey Wayne Yeager

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation traces the debates concerning the professionalization of medicine in America across the 19^th- and well into the 20^th-century and explores how the debates concerning professionalization in any given moment affected popular literary forms. Using Fredric Jameson’s The Political Unconscious as its theoretical framework, this dissertation’s chapters on the gothic, realism, naturalism, and satire trace each mode’s dominant hegemonic position on this issue while showcasing dissenting voices across this century-long discourse. This project’s methodology is centered in the New Historicism. Unlike other projects before it, this dissertation focuses primarily on the historical problem of state …

Clear Aligner Therapy Vs. Traditional Brackets On Smile Arc, Sarah Elizabeth Larue

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background and Objectives: More so than ever, the public is becoming exceedingly aware of esthetics, and will evaluate their treatment outcome based upon the improvement to their smile and overall enhancement of their facial appearance. Smile arc is considered to be a key component of facial esthetics. Literature has demonstrated that orthodontic treatment mechanics utilizing traditional brackets and wires can cause flattening of the smile arc and that smiles with flatter arcs are judged to be less attractive. The aim of this study was to determine whether clear aligner therapy can help to preserve or improve the smile arc …

A Flight Sensory-Motor To Olfactory Histamine Circuit Mediates Olfactory Processing Of Ecologically And Behaviorally Natural Stimuli, Samual P. Bradley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Environmental pressures have conferred species specific behavioral and morphological traits to optimize reproductive success. To optimally interact with their environment, nervous systems have evolved motor-to-sensory circuits that mediate the processing of its own reafference. Moth flight behavioral patterns to odor sources are stereotyped, presumably to optimize the likelihood of interacting with the odor source. In the moth Manduca sexta wing beating causes oscillatory flow of air over the antenna; because of this, odorant-antennal interactions are oscillatory in nature. Electroantennogram recordings on antennae show that the biophysical properties of their spiking activity can effectively track odors presented at the wing beat …

Impact Of Sire Selection And Breed On Parasite Resistance In Sheep, Andrew Ryan Weaver

Graduate Theses, Dissertations, and Problem Reports (ETD)

Selection within and among breeds are strategies to mitigate the impact of parasitism given failing chemotherapeutics. While Texels have improved marketability compared to other parasite-resistant breeds, the mechanism by which Texels reduce fecal egg count (FEC) is unclear. The immune response to Haemonchus contortus (Hc) was compared in Texel, parasite-resistant St. Croix, and parasite-susceptible Suffolk sheep. Adult worms exposed to St. Croix- and Texel-derived peripheral blood mononuclear cells and serum in vitro had greater binding around the reproductive structures than Suffolk and worm egg release tended to be affected by breed (P = 0.09). Resistance in Texels …