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The Urotsa Cell Line As A Model Of Human Urothelium., Michael Ronald Rossi Jan 2002

The Urotsa Cell Line As A Model Of Human Urothelium., Michael Ronald Rossi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The UROtsa cell line is a unique model of human urothelium with considerable utility in toxicology-based research. UROtsa cells maintained in serum-free medium have several morphological features of transitional epithelium of the urinary bladder including a multilayered appearance and apically located umbrella-like cells that exhibit tight junctions. These cells also have a basal expression pattern of heat shock protein (hsp) and metallothionein (MT) genes similar to that observed in in situ urothelium. To characterize the functional heat shock and metallothionein stress response in UROtsa cells, confluent cultures grown in serum-free medium were treated with a variety of acute and chronic …

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The Effects Of Age On The Chromosomal And Physiological Integrity Of Human Sperm., Eddie D. Sloter Jan 2002

The Effects Of Age On The Chromosomal And Physiological Integrity Of Human Sperm., Eddie D. Sloter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Integrated biomarkers of physiologic and genetic damage in sperm are needed to identify factors that affect male fertility and influence a father's risk of producing abnormal progeny. Offspring studies show a preferential paternal origin for heritable structural chromosomal abnormalities, presenting the need for methods to efficiently detect structural chromosomal abnormalities in human sperm. This dissertation breaks new conceptual ground toward the understanding of paternally transmitted genetic disease by adapting FISH technology to detect human sperm that carry chromosomal breaks and partial chromosomal duplications and deletions and by integrating state-of-the-art biomarkers of semen quality including computer-assisted sperm analysis (CASA). These sperm …

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Differential Reinforcement Of Fixed-Interval Interresponse Times: Effects On Choice., Tammy Renee Wade Jan 2002

Differential Reinforcement Of Fixed-Interval Interresponse Times: Effects On Choice., Tammy Renee Wade

Graduate Theses, Dissertations, and Problem Reports (ETD)

Eight rats were exposed to a concurrent-chains procedure. Half of the rats chose between a fixed-interval schedule that required low rates of responding in the paced terminal link and a simple fixed-interval schedule in the unpaced terminal link. The other half chose between a fixed-interval schedule that required high rates of responding and a simple fixed-interval schedule. Interresponse-time criteria were based on the percentiles of a baseline distribution of interresponse times obtained for each rat. The criteria increased in stringency across conditions. Consistent changes in response rates as the result of the interresponse-time criteria were not obtained. Therefore, preference between …

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Landscaping The Lehigh: The Creation Of A Middle Industrial Landscape In Nineteenth-Century Pennsylvania., Augustine Nigro Jan 2002

Landscaping The Lehigh: The Creation Of A Middle Industrial Landscape In Nineteenth-Century Pennsylvania., Augustine Nigro

Graduate Theses, Dissertations, and Problem Reports (ETD)

Located sixty miles above Philadelphia, the Lehigh Valley follows the seventy-mile path of the Lehigh River as it descends from the Pocono Mountains south through the Blue Mountains into the rich agricultural lands of the Appalachian Great Valley. With anthracite deposits in its northern reaches, rich agricultural lands in its middle section, and commercial connections to Philadelphia at its mouth, nineteenth-century industrialists saw the river as a potential transportation route. From 1817 to 1829, the Lehigh Coal and Navigation Company developed a system of slack water navigation along the river. With the opening of the channel in 1829, extractive industries …

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Identification Of Structural Features In The G-Protein Regulatory Motif Required For Regulation Of Heterotrimeric G-Proteins, Yuri K. Peterson, Starr Hazard, Stephen G. Graber, Stephen M. Lanier Jan 2002

Identification Of Structural Features In The G-Protein Regulatory Motif Required For Regulation Of Heterotrimeric G-Proteins, Yuri K. Peterson, Starr Hazard, Stephen G. Graber, Stephen M. Lanier

Faculty & Staff Scholarship

No abstract provided.

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Rapid Communication: Thirty-Eight Polymorphic Microsatellite Markers For Mapping In Rainbow Trout., C E Rexroad, R L Coleman, W K Hershberger, J Killefer Jan 2002

Rapid Communication: Thirty-Eight Polymorphic Microsatellite Markers For Mapping In Rainbow Trout., C E Rexroad, R L Coleman, W K Hershberger, J Killefer

Faculty & Staff Scholarship

No abstract provided.

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Srebp-1 Integrates The Actions Of Thyroid Hormone, Insulin, Camp, And Medium-Chain Fatty Acids On Accalpha Transcription In Hepatocytes, Yanqiao Zhang, Liya Yin, F Bradley Hillgartner Jan 2002

Srebp-1 Integrates The Actions Of Thyroid Hormone, Insulin, Camp, And Medium-Chain Fatty Acids On Accalpha Transcription In Hepatocytes, Yanqiao Zhang, Liya Yin, F Bradley Hillgartner

Faculty & Staff Scholarship

In chick embryo hepatocytes, activation of acetyl-CoA carboxylase-α (ACCα) transcription by 3,5,3′-triiodothyronine (T3) is mediated by a cis-acting regulatory unit (−101 to −71 bp) that binds the nuclear T3 receptor (TR) and sterol regulatory element-binding protein-1 (SREBP-1). SREBP-1 directly interacts with TR on the ACCα gene to enhance T3-induced transcription. Here, we show that treating hepatocytes with T3 or insulin stimulates a 4-fold increase in the concentration of the mature, active form of SREBP-1. When T3 and insulin are added together, a 7-fold increase in the mature SREBP-1 concentration is observed. Time course studies indicate that the T3-induced increase in …

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Metal-Induced Generation Of Reactive Oxygen Species And Related Cellular Injury., Stephen Sunday Leonard Jan 2002

Metal-Induced Generation Of Reactive Oxygen Species And Related Cellular Injury., Stephen Sunday Leonard

Graduate Theses, Dissertations, and Problem Reports (ETD)

Metals have been indicated in causing generation of reactive oxygen species (ROS) and cellular injury. The overall objective of the present study was to investigate ROS generation from metals and the related effects on biological systems. The results obtained from the present studies have demonstrated that: (a) Cobalt is capable of generating ·OH via a Co(I)-mediated Fenton-like reaction. (b) The ·OH radical is generated by reaction of H2O2 with Cr(V), which is produced by enzymatic one-electron reduction of Cr(VI). H2O2 is produced by reduction of molecular oxygen via O2·− as an intermediate. The ·OH radicals generated by these reactions are …

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The Effects Of Diet And Weight On Induction Of Puberty And Fertility Response In Yearling Beef Heifers., Quinn Stephan Baptiste Jan 2002

The Effects Of Diet And Weight On Induction Of Puberty And Fertility Response In Yearling Beef Heifers., Quinn Stephan Baptiste

Graduate Theses, Dissertations, and Problem Reports (ETD)

The effects of weight; high (HW) or low (LW), and diet; high-energy (HE) or low-energy (LE), on the fertility of 118 yearling Angus, Hereford, and Angus x Hereford beef heifers were investigated. Heifers were blocked by body weight, and randomly assigned to diets for 47 and 42 days in years, 1 and 2, respectively. Estrus was synchronized with MGA (8 d, 0.5mg/hd/d), PGF2α (25 mg i.m.), and estradiol benzoate (400 µg i.m, 48 h after PGF2α) regimen. Heifers were artificially inseminated between 78-84 h after the PGF2α injection and then exposed to a bull for the second service. Overall pregnancy …

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The Relationships Between Teacher Self-Disclosure, Student Motives, Student Affect, Relational Certainty, And Student Participation., Jacob L. Cayanus Jan 2002

The Relationships Between Teacher Self-Disclosure, Student Motives, Student Affect, Relational Certainty, And Student Participation., Jacob L. Cayanus

Graduate Theses, Dissertations, and Problem Reports (ETD)

The concept of teacher self-disclosure has been studied using a variety of methods. A review of teacher self-disclosure literature found that operationalization of teacher self disclosure had yet to be agreed upon by researchers. This thesis applied a new teacher self-disclosure scale developed primarily for this research. It was hypothesized teacher self-disclosure would be related to (1) the student motives of functional, relational, and participatory, (2) class participation, (3) affect for class, (4) affect for teacher, and (5) relational certainty. Analysis of data collected show teacher self-disclosure mildly correlated with the student motive of relational and student participation, but was …

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Factors Influencing Habitat Selection And Activity Of Ground Beetles (Coleoptera: Carabidae) In Central Appalachia. Part I. The Influence Of Soil And Soil Surface Characteristics On Habitat Selection By Carabidae. Part Ii. Precipitation And Temperature Fluctuations: Effects On Carabidae Activity. Part Iii. The Effects Of Two Microbial Insecticides For Gypsy Moth Control On Carabidae Populations., Terry R. Carrington Jan 2002

Factors Influencing Habitat Selection And Activity Of Ground Beetles (Coleoptera: Carabidae) In Central Appalachia. Part I. The Influence Of Soil And Soil Surface Characteristics On Habitat Selection By Carabidae. Part Ii. Precipitation And Temperature Fluctuations: Effects On Carabidae Activity. Part Iii. The Effects Of Two Microbial Insecticides For Gypsy Moth Control On Carabidae Populations., Terry R. Carrington

Graduate Theses, Dissertations, and Problem Reports (ETD)

A study was conducted in the George Washington National Forest in Virginia and the Monongahela National Forest in West Virginia. Carabid samples were collected over four years and compared to soil characteristics, surface characteristics and meteorological conditions to determine what role these factors play in carabid habitat selection. Opportunity also existed to compare carabid populations before and after the application of microbial insecticides on the sampling sites. This study was conducted as as part of a larger project investigating non-target impacts from gypsy moth, Lymantria dispar (L.)(Lepidoptera: Lymantriidae), insecticide applications and the interaction of Entomophaga maimaiga Humber, Shimazu, and Soper …

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The Longest Distance Between Two Points., David Lee Chance Jan 2002

The Longest Distance Between Two Points., David Lee Chance

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Longest Distance Between Two Points is a collection of short fiction and nonficiton stories written between spring semester of 2000 and spring semester of 2002 and compiled for my master's thesis. Three of the pieces were written for this collection and the other two are revisions of works composed for graduate writing workshops. The stories all deal with people who have some type of personal limitation that causes them to have trouble functioning in the world. Some of the themes that are explored in these stories are poverty, addiction, mental illness, language barriers and physical handicaps. Each story deals …

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An Evaluation Of Double-Observer Point Count Techniques And Avian Habitat Use On The Camp Dawson Collective Training Area, Preston County, West Virginia., Greg Michael Forcey Jan 2002

An Evaluation Of Double-Observer Point Count Techniques And Avian Habitat Use On The Camp Dawson Collective Training Area, Preston County, West Virginia., Greg Michael Forcey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Double-observer point counts are a new method of inventorying avian fauna that allow detection probabilities to be calculated for each point or species of bird. These detection rates allow estimation of abundances that are more robust than estimates derived from single-observer counts because detection probabilities factor in birds present but not detected. The combined double-observer (DO) technique involves two observers recording data together on a single data sheet. The primary observer dictates the number of each species that is detected while the secondary observer records this information; the secondary observer also notes birds that the primary observer did not detect. …

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The Identification Of Downstream Effectors Of The Rx Gene And Its Proposed Role In Anophthalmia/Microphthalmia., Christina Marie O'Kernick Jan 2002

The Identification Of Downstream Effectors Of The Rx Gene And Its Proposed Role In Anophthalmia/Microphthalmia., Christina Marie O'Kernick

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Retinal homeobox (Rx) gene codes for a transcriptional regulator involved in retinal tissue development, and the protein sequence of this transcription factor has been highly conserved throughout evolution. Previous Rx-knock-out and over-expression experiments have identified Rx as an essential component for proper eye formation. Here we used gene sequencing to identify 2 different mutations in the hRx gene of three anophthalmic and microphthalmic patients. The Q147X mutation, located in helix 1 of the homeodomain most likely prevents Rx from binding to DNA, therefore preventing transcriptional regulation by Rx. The R192Q mutation located in helix 3 of the homeodomain is …

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Environmental Justice Through Pollution Prevention: Development Of A Quantitative Method To Assess Community Vulnerability And Air Emission Hazard For Optimal Impact., John Lewis Boettner Iii Jan 2002

Environmental Justice Through Pollution Prevention: Development Of A Quantitative Method To Assess Community Vulnerability And Air Emission Hazard For Optimal Impact., John Lewis Boettner Iii

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study develops a quantitative and objective method of analyzing community vulnerability combined with potential exposure to emission hazards. This extends earlier work concerning Environmental Justice Through Pollution Prevention (EJP2) initiatives for optimal selection of facilities for resource allocation for pollution prevention initiatives. A 1992 EPA report indicated that minority and low-income communities are exposed to higher levels of pollution in their neighborhoods than that of the general population. Environmental Justice is a grassroots derived term for addressing these disproportionate shares of negative environmental impacts, which are placed upon people of minority or low socio-economic status. The method developed identifies …

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A Uses And Gratifications Analysis Of Consumer Satisfaction Correlated To Expectations In E-Commerce Retail Shopping., Stacey Ann Torjak Jan 2002

A Uses And Gratifications Analysis Of Consumer Satisfaction Correlated To Expectations In E-Commerce Retail Shopping., Stacey Ann Torjak

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research is an exploration of how retail is moving from the mall to the Internet. It applies uses and gratifications analysis of consumer satisfaction and ecommerce Web sites. The study compares obtained and sought after e-commerce consumer gratifications. The participants for the study attended West Virginia University in the spring 2002 semester. The study produced 50 valid responses that found consumers sought after gratifications for product display and navigation features were not met. This research also shows that experienced Internet consumers trust e-commerce Web sites privacy/security features. Implications for companies with e-commerce Web sites are explored.

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Personal Tobacco Use Behaviors And Tobacco Cessation Activities Of Dental And Dental Hygiene Students In United States Dental Schools., Amanda Suzanne Hatfield Jan 2002

Personal Tobacco Use Behaviors And Tobacco Cessation Activities Of Dental And Dental Hygiene Students In United States Dental Schools., Amanda Suzanne Hatfield

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to determine and compare the tobacco use behaviors of dental and dental hygiene students enrolled in U.S. dental schools with their perceptions and performance of tobacco use cessation counseling activities (TUCCA). A survey was mailed to a stratified sampling of accredited dental schools with which dental hygiene programs (n=8) were affiliated. Results were reported in frequencies, cumulative frequencies, and percentages. With use of the JMP program, Chi Square analyses were performed to test for statistical significance. Response rates of 57.1% from the dental programs (n=7) and 100% from the dental hygiene programs (n=8) were …

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The Induction Of Sensitization And Airway Hyperreactivity By 3-Amino-5-Mercapto-1,2,4-Triazole In A Murine Model., Kimberly Jean Klink Jan 2002

The Induction Of Sensitization And Airway Hyperreactivity By 3-Amino-5-Mercapto-1,2,4-Triazole In A Murine Model., Kimberly Jean Klink

Graduate Theses, Dissertations, and Problem Reports (ETD)

An increase in the incidence of respiratory disease reported in a herbicide producing factory correlates with potential exposure to 3-Amino-5-mercapto-1,2,4-triazole (AMT) and AMT based product 1 (AMT-bp1). In animal studies, no signs of systemic toxicity or irritancy were observed with concentrations up to 25% AMT or 40% AMT-bp1. AMT-bp1 was negative while a dose dependent increase was observed following exposure to AMT in the LLNA. An increase in B220+IgE+ cells was observed at 25% AMT exposure. AMT was negative in the MEST (up to 25%). Following dermal exposure 5 days a week, animals exposed to 25% AMT demonstrated elevated levels …

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A Model For Building A Better Academic Web Site: A Quantitative Analysis Of Foreign Language Departments On The World Wide Web., Margarita (Maria) M. Toro Jan 2002

A Model For Building A Better Academic Web Site: A Quantitative Analysis Of Foreign Language Departments On The World Wide Web., Margarita (Maria) M. Toro

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis defines what an effective academic web site is, and examines the utilization of web sites by the Land Grant colleges’ foreign language departments. A system with the parameters of evaluation was created from studies that observed web users’ perceptions of web sites. Four main factors were analyzed: informativeness, interactivity, entertainment, design and usability. The results showed that departments of foreign language are not projecting a positive image throughout their web sites. Moreover, the web masters of the foreign language departmental sites are not considering entertainment and interactivity features as fundamental elements in the development of academic web sites.

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An Investigation Into The Mechanism Of 2-Oxohistidine Formation From The Peroxidase Activity Of Superoxide Dismutase., Joseph Andrew Peters Jan 2002

An Investigation Into The Mechanism Of 2-Oxohistidine Formation From The Peroxidase Activity Of Superoxide Dismutase., Joseph Andrew Peters

Graduate Theses, Dissertations, and Problem Reports (ETD)

The pathogenesis of familial amyotrophic lateral sclerosis (fALS), a fatal neurodegenerative disease that sometimes results from SOD1 mutations, may involve the peroxidase reaction of the SOD1 protein. The aim of this thesis was to test the hypothesis that the peroxidase reaction of SOD results in SOD-centered peroxyl radical formation. The source of oxygen incorporated into 2-oxohistidine was to have been determined using HPLC/Mass spectrometry. This aim was not accomplished. UV-Visible difference spectrometry provided evidence for a peroxyl radical in this reaction. 2-oxohistidine formation was shown to be oxygen dependent and inhibited by the spin-trap MNP (Gunther, Peters, and Sivaneri 2002 …

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An Assessment Of Natural Cavity Abundance, Nest Box Use, And Management Recommendations For Birds On The Ohio River Islands National Wildlife Refuge, West Virginia., Karen A. Sacilotto Jan 2002

An Assessment Of Natural Cavity Abundance, Nest Box Use, And Management Recommendations For Birds On The Ohio River Islands National Wildlife Refuge, West Virginia., Karen A. Sacilotto

Graduate Theses, Dissertations, and Problem Reports (ETD)

Islands on the Ohio River contain valuable habitats that are unique and irreplaceable on a national or ecoregion basis. Aquatic habitats connected with the islands and their back channels (areas where commercial traffic is prohibited) provide quality habitats for bottomland hardwood wildlife; however, quantitative data on the importance of these areas are lacking. The objectives of this study were to: 1) compare breeding bird abundance and quality of habitat for cavity-nesting birds between back channel and navigational channel sides of islands, and 2) analyze the effects of nest box placement on cavity-nesting bird-use on the Ohio River Islands National Wildlife …

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Effects Of High -Dose Chemotherapy On The Bone Marrow Microenvironment, Brett Matthew Hall Jan 2002

Effects Of High -Dose Chemotherapy On The Bone Marrow Microenvironment, Brett Matthew Hall

Graduate Theses, Dissertations, and Problem Reports (ETD)

The bone marrow microenvironment composed in part of stromal cells provides the niche in which normal hematopoiesis occurs. Hematopoiesis generates cellular components of the immune system and blood through proliferation and differentiation of multipotent hematopoietic stem cells (HSC). In preparation for bone marrow transplantation, radiation or chemotherapy treatment temporarily disrupts the balance of hematopoiesis as many HSC and progenitor cells are destroyed. Following treatment cessation, transplanted HSC and progenitor cells migrate, or "home", back to the bone marrow microenvironment and initiate productive hematopoiesis. While the mechanism of bone marrow homing is not completely understood, several soluble factors and adhesion molecules …

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The Study Of Glucose-6-Phosphate Dehydrogenase (G6pd) Gene Regulation In Hepg2 Cells By Glucose Induction And The Study Of G6pd Mrna Localization By Fluorescent In Situ Hybridization (Fish)., Brian Nelson Griffith Jan 2002

The Study Of Glucose-6-Phosphate Dehydrogenase (G6pd) Gene Regulation In Hepg2 Cells By Glucose Induction And The Study Of G6pd Mrna Localization By Fluorescent In Situ Hybridization (Fish)., Brian Nelson Griffith

Graduate Theses, Dissertations, and Problem Reports (ETD)

HepG2 cells were used as a model system to study the regulation of glucose-6- phosphate dehydrogenase (G6PD). Regulation of hepatic G6PD expression involves changes in the amount of G6PD pre-mRNA in the nucleus in the absence of changes in the transcription rate of the gene. G6PD expression is increased in HepG2 cells incubated with increasing glucose concentrations. G6PD mRNA is increased 3- to 4- fold by incubation in 25 mM glucose, as compared to 0 mM glucose. To determine the cis-acting element involved in this regulation, HepG2 cells were stably transfected with G6PD genomic DNA composed of exons 7 through …

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Part 1: Structure, Stability And Reactivity Of Small Biologically-Active Organosulfur Compounds. Part 2: Generation Of Reactive Oxygen Species In The Enzymatic Reduction Of Chromium(Vi) And Arsenic(V) And Its Implications In Metal-Induced Carcinogenesis., Oluwarotimi Odunayo Olojo Jan 2002

Part 1: Structure, Stability And Reactivity Of Small Biologically-Active Organosulfur Compounds. Part 2: Generation Of Reactive Oxygen Species In The Enzymatic Reduction Of Chromium(Vi) And Arsenic(V) And Its Implications In Metal-Induced Carcinogenesis., Oluwarotimi Odunayo Olojo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Structure, stability, kinetics and mechanisms of oxidation of some important organosulfur compounds (2-aminoethanethiolsulfuric acid, 4-methyl-3-thiosemicarbazide and thionicotinamide) have been investigated by using UV-VIS, NMR, stopped-flow, and qualitative analysis. Results obtained showed that oxidation occurs mainly at the reactive sulfur center of the molecules via successive addition of oxygen atoms. The oxidation of thionicotinamide, an important xenobiotic, gave different oxygenated products, depending on the oxidizing power of the oxidant used. The sulfinic acid of thionicotinamide is stable with mild oxidizing agents while stronger oxidants desulfurize the molecule to yield sulfate as observed with other organosulfur compounds studied. Mechanism of oxidation leading …

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Gene Expression During Skeletal Muscle Development: Effect Of In Ovo Igf-1 Administration On Broiler Embryogenesis And Postnatal Myogenesis In The Mouse., Jennifer Jo Richter Jan 2002

Gene Expression During Skeletal Muscle Development: Effect Of In Ovo Igf-1 Administration On Broiler Embryogenesis And Postnatal Myogenesis In The Mouse., Jennifer Jo Richter

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Myogenic Regulatory Factor family (MRFs) is a family of transcription factors that plays a key role in the development of skeletal muscle. MRFs include Myo D, myf-5, myogenin, and MRF-4. Myo D and myf-5 are genes expressed during myoblast proliferation, whereas myogenin and MRF-4 are expressed during myotube formation and differentiation. Insulin-Like Growth Factor 1 (IGF-1) controls muscle development both embryonically and during postnatal growth and repair by inducing myoblast proliferation and muscle hypertrophy. We determined the mRNA expression patterns of the MRFs during muscle development of the chicken and the effect of recombinant human IGF-1 (rhIGF-1) on these …

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Building The Beaver And Lake Erie Canal: The Politics Of Public Improvements In Pennsylvania, 1783-1845., William David Mccarthy Jan 2002

Building The Beaver And Lake Erie Canal: The Politics Of Public Improvements In Pennsylvania, 1783-1845., William David Mccarthy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Patterns of commerce and settlement in colonial America were shaped by watercourses and portages. Road building skills were primitive and boating represented the most effective means of moving bulk freight and passengers. Traders and frontiersmen leading the advance of European settlement into the Appalachian Mountains therefore adopted the shortest crossings between watersheds. Natural conditions in Pennsylvania did not promote an orderly advance westward and produced isolated clusters of settlement around Philadelphia and Pittsburgh, with small and widespread settlements in Northwest Pennsylvania. State leaders were hard pressed to define the limits of Pennsylvania until the end of the eighteenth century, and …

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Land Use, Environmental Quality And Public Policy: Interactions And Implications For Agricultural Sustainability., Ramkumar Bendapudi Jan 2002

Land Use, Environmental Quality And Public Policy: Interactions And Implications For Agricultural Sustainability., Ramkumar Bendapudi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Population growth, combined with economic growth have been primary causes of urban sprawl and increased pressure on natural resources. Urban development often adversely affects land, water and air quality. Although not considered a threat to the nation's food production, land development and urbanization are critical issues because they can lead to fragmentation of agricultural and forest lands, loss of prime farmland, wildlife habitat and other resources, additional infrastructure costs for communities and regional authorities, and competition for water. These losses raise concerns about sustainability of land and agriculture. Various state-sponsored programs such as Purchase of Developmental Rights and Transfer of …

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The Impact Of A Language Learning Context On Chinese Students Learning English., Saundra Enany Faris Jan 2002

The Impact Of A Language Learning Context On Chinese Students Learning English., Saundra Enany Faris

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to examine English language acquisition in four ESL children whose native country is China. Each of the four children was considered individually and holistically through case study methodology, and some comparisons across children were considered. A second purpose of this study was to look holistically at the instructional strategies used to support language acquisition for each of these students. In addition, this research investigated the perceptions of the four Chinese ESL students regarding strategies and instructional methods used to facilitate English language acquisition at one or two elementary schools in a rural state in …

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The Significance Of Metallothionein Isoform 3 Gene Expression In Human Prostate Cancer., Rana Dutta Jan 2002

The Significance Of Metallothionein Isoform 3 Gene Expression In Human Prostate Cancer., Rana Dutta

Graduate Theses, Dissertations, and Problem Reports (ETD)

Since the expression of the brain specific metallothionein isoform, MT-3, was shown to be expressed in many, but not all prostate cancers, this gene was transfected into the commonly utilized prostate tumor cell line, PC-3, to study the consequence of MT-3 expression on growth rate and resistance to chemotherapeutic agents. PC-3 cells were stably transfected with MT-3 or MT-1E under control of the constitutive CMV promoter. The levels of MT-3 protein for the 5 overexpressing clones had an average level of 8.3 ng MT-3 per μg protein as assessed by quantitative immunodot blot analysis, and three were picked for further …

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The Relationship Between West Virginia School Principals' Self-Perceived Brain Hemispheric Cognitive Styles/Leadership Styles And Identified Schools Of Excellence., James Perry Varner Jan 2002

The Relationship Between West Virginia School Principals' Self-Perceived Brain Hemispheric Cognitive Styles/Leadership Styles And Identified Schools Of Excellence., James Perry Varner

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to identify the predominant self-perceived brain hemispheric cognitive styles and leadership styles of principals of schools identified as a West Virginia School of Excellence and to compare these with principals of schools that have not been identified as a West Virginia School of Excellence. The following research questions provided the focus for this study: Is there a difference between West Virginia principals of schools identified as a West Virginia School of Excellence and principals of schools not identified as a School of Excellence who perceive themselves as: (1) Right brain hemispheric cognitive style and …

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