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Effects Of Morphine, D-Amphetamine, And Food Deprivation On Temporally Organized Behavior, Todd William Knealing May 2002

Effects Of Morphine, D-Amphetamine, And Food Deprivation On Temporally Organized Behavior, Todd William Knealing

Graduate Theses, Dissertations, and Problem Reports (ETD)

Two experiments examined the effects of morphine and d-amphetamine on behavior that was temporally organized under several schedule arrangements. Two body weights were assessed for each experiment. Experiment 1 made use of fixed-interval (FI) schedules, the peak procedure, and a two-key (free-operant psychophysical) procedure. Indexes of timing performance under each of these schedules were assessed and compared. Timing indexes were decreased by both drugs in the two-key procedure, but were not reliably altered in the peak procedure. Both drugs produced clear rate-dependent effects on behavior in both procedures. In Experiment 2, FI performance was assessed both alone and with a …

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Antitumor Activity Of Antimalarials In Human Breast Cancer Cells, Qun Zhou May 2002

Antitumor Activity Of Antimalarials In Human Breast Cancer Cells, Qun Zhou

Graduate Theses, Dissertations, and Problem Reports (ETD)

Previously we showed that quinidine arrested MCF-7 cells in G1 phase of the cell cycle and led to a G1 to G0 transition followed by apoptotic cell death (Wang et al., 1998). The present experiments demonstrate that MCF-7, MCF-7ras, T47D, MDA-MB-231, and MDA-MB-435 cells transiently differentiate before undergoing apoptosis in response to quinidine. The cells accumulated lipid droplets and the cytokeratin 18 cytoskeleton was reorganized. Hyperacetylated histone H4 appeared within 2 h of the addition of quinidine to the medium, and levels were maximal by 24 h. Quinidine treated MCF-7 cells showed elevated p21/WAF1, hypophosphorylation and suppression of retinoblastoma protein, …

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Influence Of Mass Of Ruminal Contents On Voluntary Intake And Digesta Passage Of A Concentrate And A Forage Diet, Marcela Ana Whetsell May 2002

Influence Of Mass Of Ruminal Contents On Voluntary Intake And Digesta Passage Of A Concentrate And A Forage Diet, Marcela Ana Whetsell

Graduate Theses, Dissertations, and Problem Reports (ETD)

To evaluate the influence of mass of rumen contents on voluntary intake and rumen function, five ruminally cannulated steers (500 kg) were fed a hay diet ad libitum in a 5 x 5 Latin square experiment. Mass of ruminal contents was altered by adding varying weights of modified tennis balls to the rumen before the initiation of each experimental period. Treatments consisted of 50 balls with a specific gravity (SG) of either 1.0, 1.1, 1.2, 1.3 or 1.4 and the total weight of the balls was 7.45 kg, 8.50 kg; 9.25 kg, 10.55; and 11.55 kg, respectively. Daily DMI was …

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Analysis And Robust Decentralized Control Of Power Systems Using Facts Devices, Karl E. Schoder May 2002

Analysis And Robust Decentralized Control Of Power Systems Using Facts Devices, Karl E. Schoder

Graduate Theses, Dissertations, and Problem Reports (ETD)

Today's changing electric power systems create a growing need for flexible, reliable, fast responding, and accurate answers to questions of analysis, simulation, and design in the fields of electric power generation, transmission, distribution, and consumption. The Flexible Alternating Current Transmission Systems (FACTS) technology program utilizes power electronics components to replace conventional mechanical elements yielding increased flexibility in controlling the electric power system. Benefits include decreased response times and improved overall dynamic system behavior. FACTS devices allow the design of new control strategies, e.g., independent control of active and reactive power flows, which were not realizable a decade ago. However, FACTS …

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Small Mammal Communities On A Reclaimed Mountaintop Mine/Valley Fill Landscape In Southern West Virginia, Howard Douglas Chamblin May 2002

Small Mammal Communities On A Reclaimed Mountaintop Mine/Valley Fill Landscape In Southern West Virginia, Howard Douglas Chamblin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mountaintop mine/valley fill is a large-scale form of strip mining whose effects on small mammals had not previously been examined. Small mammals were captured by Sherman trap and drift fence array (pitfall and funnel traps) on 3 treatments representing the mined landscape and intact forests representing the unmined condition. Peromyscus ( P. leucopus and maniculatus) dominated Sherman captures and were the most common array capture. Eastern chipmunks (Tamias striatus), woodland jumping mice (Napaeozapius insignus), woodland voles (Microtus pinetorum), northern short-tailed shrews (Blarina brevicauda), and pygmy shrews (Sorex hoyi) were more common in forest treatments; Peromyscus, house mice (Mus musculus), southern …

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Nest-Site Resources For Cavity-Nesting Birds In The Southern Allegheny Mountain Forests Of West Virginia, Harry A. Kahler May 2002

Nest-Site Resources For Cavity-Nesting Birds In The Southern Allegheny Mountain Forests Of West Virginia, Harry A. Kahler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cavity-nesting birds may be negatively impacted by a lack of proper nesting sites. Southern Allegheny Mountain forests of West Virginia are unique due to the juxtaposition and diversity of forest cover types. Management must focus on monitoring wildlife population levels as well as habitat requirements within each cover type. Cavity tree abundance significantly differed among central hardwood (x¯ = 16.4; SE = 5.3), northern hardwood (x¯ =12.7; SE = 6.8), and boreal forest cover types (x¯ = 7.2; SE = 3.6) ( P < 0.0001). Black locust (Robinia pseudoacacia) and American beech (Fagus grandifolia) were most likely to have tree cavities, yet beech may be influenced by increased mortality from recent outbreaks of beech bark disease initiated by the beech scale insect (Cryptacoccus fagisuga). Nesting bird community density, richness, and abundance do not differ among mature forests of the 3 cover types. Cavity-nesting species dependent on available tree holes were found most in the central hardwoods (P = 0.009). Forest managers should consider landscape level effects, as well as forest stand composition, when recommending silvicultural treatments.

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Effect Of Increased Energy In A Restricted Diet On Bone Mineral Composition And Breaking Load Of Young Rat Tibias, Marcia Ann Romanchak May 2002

Effect Of Increased Energy In A Restricted Diet On Bone Mineral Composition And Breaking Load Of Young Rat Tibias, Marcia Ann Romanchak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Osteoporosis is a major health problem in the United States and those that are on energy restricted diets such as anorectic subjects. Thirty Wistar strain, young male rats were fed diets with varying quantities of fat for a period of four weeks (energy intake 67--75% of requirement). The rat tibias' physical properties were measured. Bone mineral composition testing was conducted for calcium, magnesium, and phosphorus, on the tibia shaft. There were no significant differences among the parameters of length, diameter, volume, density, bone bending (elasticity), fracture load, and minerals between experimental diets. There was a negative association between bending and …

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Comparison Of Herpetofaunal Species Composition And Response To Edge On The Camp Dawson Collective Training Area, Preston County, West Virginia, Amy B. Spurgeon May 2002

Comparison Of Herpetofaunal Species Composition And Response To Edge On The Camp Dawson Collective Training Area, Preston County, West Virginia, Amy B. Spurgeon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Herpetofaunal species composition, abundance, and diversity were evaluated on the Camp Dawson Collective Training Area, Preston County, West Virginia, as a requirement of the Sikes Act (16 USC 670a et seq.), Army Regulation 200-3, and Department of Defense Instruction 4715.3. Herpetofauna were sampled using pitfall traps with drift fences and double-ended funnel traps, and also from area searches. Redback salamander (Plethodon cinereus), red-spotted newt (Notophthalmus v. viridescens ), eastern American toad (Bufo a. americanus), and wood frog (Rana sylvatica) were most common in pitfall arrays; mountain dusky salamander (Desmognathus ochrophaeus), Appalachian seal salamander (Desmognathus m. monticola), and redback salamander were …

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Retention Of Early Pregnancy And Its Relationship To Serum Progesterone In Dairy Cattle, Melanie J. Starbuck May 2002

Retention Of Early Pregnancy And Its Relationship To Serum Progesterone In Dairy Cattle, Melanie J. Starbuck

Graduate Theses, Dissertations, and Problem Reports (ETD)

Factors affecting pregnancy maintenance between 28 and 67 days of gestation were studied in dairy cows (N = 211). Beginning on day 28 to 37 post breeding, cows were examined by ultrasonography for a viable pregnancy. Pregnant cows were re-examined for pregnancy losses during the late embryonic (≤day 45) and early fetal stages up to day 67. Overall pregnancy loss was 11%, mostly occurring before day 45. Cows with two corpora lutea maintained fewer pregnancies than cows with one corpus luteum. Pregnancy retention was less when concentrations of progesterone were low during days 28 to 37. The embryo apparently died …

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Relationship Between Maternal Prenatal Vitamin Use And Infant Iron Status, Jennie Pringle Wilkins May 2002

Relationship Between Maternal Prenatal Vitamin Use And Infant Iron Status, Jennie Pringle Wilkins

Graduate Theses, Dissertations, and Problem Reports (ETD)

Subjects were fifty-six women and their infants who were between the ages of six months and twenty-four months. They were clients of Special Supplemental Nutrition Program for Women Infants and Children (WIC) clinics. The WIC clinics were in the West Virginia counties of Ritchie, Gilmer, Calhoun, Braxton, Mason, Jackson, Pleasants, and Greenbrier where the anemia rates were greater than 10%.;Information concerning WIC participation, prenatal vitamin use, history of breast feeding, infant birth weight, and pre-term delivery were obtained through questionnaires. Infants' serum ferritin level was obtained through venous blood and analyzed.;This ex post facto study found no significant result in …

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Rehnquist's Renunciation - The Chief Justice's Constitutional Duty To Preside Over Impeachment Trials, Michael F. Williams Apr 2002

Rehnquist's Renunciation - The Chief Justice's Constitutional Duty To Preside Over Impeachment Trials, Michael F. Williams

West Virginia Law Review

No abstract provided.

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Admitting Expert Testimony In Federal Courts And Its Impact On West Virginia Jurisprudence, Robin Jean Davis Apr 2002

Admitting Expert Testimony In Federal Courts And Its Impact On West Virginia Jurisprudence, Robin Jean Davis

West Virginia Law Review

No abstract provided.

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All In A Day's Work: Employers' Vicarious Liability For Sexual Harassment, Paula J. Dalley Apr 2002

All In A Day's Work: Employers' Vicarious Liability For Sexual Harassment, Paula J. Dalley

West Virginia Law Review

No abstract provided.

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Alteration Of Intracellular Cysteine And Glutathione Levels In Alveolar Macrophages And Lymphocytes By Diesel Exhaust Particle Exposure., Nabil H. Al-Humadi, Paul D. Siegel, Daniel M. Lewis, Mark W. Barger, Jane Y C Ma, David N. Weissman, Joseph K H Ma Jan 2002

Alteration Of Intracellular Cysteine And Glutathione Levels In Alveolar Macrophages And Lymphocytes By Diesel Exhaust Particle Exposure., Nabil H. Al-Humadi, Paul D. Siegel, Daniel M. Lewis, Mark W. Barger, Jane Y C Ma, David N. Weissman, Joseph K H Ma

Faculty & Staff Scholarship

The purpose of this study was to characterize the effects of diesel exhaust particles (DEP) on thiol regulation in alveolar macrophages (AM) and lymphocytes. We obtained AM and lymph node (thymic and tracheal) cells (LNC) (at different time points) from rats exposed intratracheally to DEP (5 mg/kg) or saline, and measured inflammatory markers, thiol levels, and glutathione reductase (GSH-R) activity. DEP exposure produced significant increases in neutrophils, lactate dehydrogenase, total protein, and albumin content in the lavage fluid. AM from DEP-exposed rats showed a time-dependent increase in intracellular cysteine (CYSH) and GSH. In LNC the intracellular GSH reached peak level …

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Vanadate-Induced Expression Of Hypoxia-Inducible Factor 1Α And Vascular Endothelial Growth Factor Through Phosphatidylinositol 3-Kinase/Akt Pathway And Reactive Oxygen Species, Ning Gao, Min Ding, Jenny Z. Zheng, Zhuo Zhang, Stephen S. Leonard, Ke Jian Liu, Xianglin Shi, Bing-Hua Jiang Jan 2002

Vanadate-Induced Expression Of Hypoxia-Inducible Factor 1Α And Vascular Endothelial Growth Factor Through Phosphatidylinositol 3-Kinase/Akt Pathway And Reactive Oxygen Species, Ning Gao, Min Ding, Jenny Z. Zheng, Zhuo Zhang, Stephen S. Leonard, Ke Jian Liu, Xianglin Shi, Bing-Hua Jiang

Faculty & Staff Scholarship

No abstract provided.

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Inhibition Of The Splicing Of Glucose-6-Phosphate Dehydrogenase Precursor Mrna By Polyunsaturated Fatty Acids, Huimin Tao, Wioletta Szeszel-Fedorowicz, Batoul Amir-Ahmady, Matthew A. Gibson, Laura P. Stabile, Lisa M. Salati Jan 2002

Inhibition Of The Splicing Of Glucose-6-Phosphate Dehydrogenase Precursor Mrna By Polyunsaturated Fatty Acids, Huimin Tao, Wioletta Szeszel-Fedorowicz, Batoul Amir-Ahmady, Matthew A. Gibson, Laura P. Stabile, Lisa M. Salati

Faculty & Staff Scholarship

No abstract provided.

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Caveolin-1 Expression Enhances Endothelial Capillary Tubule Formation, Jun Liu, Xiao Bo Wang, David S. Park, Michael P. Lisanti Jan 2002

Caveolin-1 Expression Enhances Endothelial Capillary Tubule Formation, Jun Liu, Xiao Bo Wang, David S. Park, Michael P. Lisanti

Faculty & Staff Scholarship

No abstract provided.

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Histidinyl Radical Formation In The Self-Peroxidation Reaction Of Bovine Copper-Zinc Superoxide Dismutase, Michael R. Gunther, J. Andrew Peters, Meena K. Sivaneri Jan 2002

Histidinyl Radical Formation In The Self-Peroxidation Reaction Of Bovine Copper-Zinc Superoxide Dismutase, Michael R. Gunther, J. Andrew Peters, Meena K. Sivaneri

Faculty & Staff Scholarship

No abstract provided.

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Hay Quality Vs Hay Quantity, Edward Barrow Rayburn Jan 2002

Hay Quality Vs Hay Quantity, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

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Proper Handling And Curing Of Hay, Edward Barrow Rayburn Jan 2002

Proper Handling And Curing Of Hay, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

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Insights Into The Nature Of Retroviral Replication And Infection: Analyses Of Minus-Strand Dna Transfer, Double Infection, And Virion And Rna Dimer Maturation., Que Dang Jan 2002

Insights Into The Nature Of Retroviral Replication And Infection: Analyses Of Minus-Strand Dna Transfer, Double Infection, And Virion And Rna Dimer Maturation., Que Dang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Retroviruses are a family of RNA viruses that replicate through DNA intermediates by reverse transcribing their genome. One of the essential steps of reverse transcription is minus-strand DNA transfer, during which nascent DNA switches template usage from the 5′ end to near the 3′ of the viral RNA genome. We have determined that minus-strand DNA transfer is homology driven; a minimum homology length is required to align the newly synthesized DNA with the 3′ RNA template to facilitate an efficient and accurate transfer. In addition to the obligatory template strand transfer events necessary to complete reverse transcription, template switching also …

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The Life And Keyboard Works Of (Franz) Xaver Scharwenka (1850-1924), Michael Patrick Mihalyo Jan 2002

The Life And Keyboard Works Of (Franz) Xaver Scharwenka (1850-1924), Michael Patrick Mihalyo

Graduate Theses, Dissertations, and Problem Reports (ETD)

(Franz) Xaver Scharwenka (1850-1924) was a highly acclaimed performer, teacher, editor, and composer of international fame during the late Romantic period. Overshadowed by the innovative styles of a number of contemporaneous composers including Ravel, Debussy, and Scriabin, Scharwenka's works gradually disappeared from the teaching studio and the concert hall. Regrettably, his compositions, although critically acclaimed in his lifetime, are now for the most part out of print and rarely performed. This study explores Scharwenka's works as a significant addition to the repertory of the late Romantic literature for study and performance. This research project, the result of a lengthy investigation …

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Hate Crime In The Media: A Content Analysis Of "The Washington Post" And "The New York Times"., Jennifer Michelle Hatcher Jan 2002

Hate Crime In The Media: A Content Analysis Of "The Washington Post" And "The New York Times"., Jennifer Michelle Hatcher

Graduate Theses, Dissertations, and Problem Reports (ETD)

In 1990, the United States Congress passed the Hate Crime Statistics Act (HCSA) which set into motion the development of a law-enforcement based data collection system aimed at learning more about “hate crimes.” By 1999 the term “hate crime” had become so widely used and recognizable that when news broke of the murders of Matthew Shephard, a University of Wyoming student who was brutally murdered because he was gay, and James L. Byrd, a disabled black man who was savagely murdered because of his race, the media understandably labeled these acts as “hate crimes.” In this paper the authors will …

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Costume Design For "The Emperor's New Clothes" By Charlotte Chorpenning., Kathleen Hoover Jan 2002

Costume Design For "The Emperor's New Clothes" By Charlotte Chorpenning., Kathleen Hoover

Graduate Theses, Dissertations, and Problem Reports (ETD)

This document records the costume design process for West Virginia University’s December 2000 production of The Emperor’s New Clothes. The costume design was produced and completed as partial fulfillment of the requirements for the Master of Fine Arts degree in Theatre Design, Costume. Contained herein are: a history of the play and playwright, critical reactions to the production, a synopsis of the action, an introduction to the design process with a concept statement, and text demonstrating the final costume designs with examples of the research, graphics, and performance photographs. Also included are a bibliography, an explanation of some important craft …

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Wheat, Wealth, And Western Maryland: The Growth And Evolution Of Flour Milling In Frederick County, Maryland, 1748-1789., John F. Kvach Jan 2002

Wheat, Wealth, And Western Maryland: The Growth And Evolution Of Flour Milling In Frederick County, Maryland, 1748-1789., John F. Kvach

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis explores the evolution of flourmills in Frederick County, Maryland within the context of the economic and social development of western Maryland from 1748-1789. Western Maryland’s development differed greatly from that of most other areas in Maryland. A large German immigrant population, along with English and Scottish settlers, settled the valleys, of present day Frederick County, during the eighteenth century. These settlers grew wheat and created a need for mills and millers. Economically, mills created prosperity by attracting new businesses and settlers to the frontier. Politically and socially, millers influenced a region often in conflict with the tobacco interests …

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Atmosphere: Transformation And Process., Jason Thomas Bohnert Jan 2002

Atmosphere: Transformation And Process., Jason Thomas Bohnert

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis document relays my graduate experience of discovering my voice in clay. My research involved the discovery of clay, glazes, and forms suited to my personal aesthetic as related to atmospheric firings and kiln experimentation. Developing my own expressions as pots based on my travels, culinary habits, and interactions with others and my natural environment was my goal. My work is heavily influenced by Chinese traditional pottery making techniques and tea culture. Many contemporary American potters have influenced my style, technique, and methodology as well. Merging traditions is of great importance to my work, allowing old traditions to live …

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Narrating Machines: Figurations Of Technology In "1 Henry Vi", "Robinson Crusoe", And "The Matrix"., Robert Patton Fanning Jan 2002

Narrating Machines: Figurations Of Technology In "1 Henry Vi", "Robinson Crusoe", And "The Matrix"., Robert Patton Fanning

Graduate Theses, Dissertations, and Problem Reports (ETD)

This essay attempts to demonstrate a tradition of the narrative use of technological tropes in Anglo-American popular narratives since the Renaissance. A play by William Shakespeare, a narrative by Daniel Defoe, and a recent movie are analyzed and compared to show the varying ways that technology has consistently figured in narrative attempts to address the contemporary social concerns narratively.

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Development Of Antibiotic Resistance Due To Chromosomal Mutation Caused By Ah26 Endodontic Sealer., Jason J. Hales Jan 2002

Development Of Antibiotic Resistance Due To Chromosomal Mutation Caused By Ah26 Endodontic Sealer., Jason J. Hales

Graduate Theses, Dissertations, and Problem Reports (ETD)

The endodontic resin sealer AH26® has been shown in multiple studies to have mutagenic potential. A unique test designed to identify phenotypic change in antibiotic resistance due to chromosomal mutation was described and performed. This test, modeled after the Ames test, used the Salmonella typhimurium (TA100) as the test organism. The test was divided into four phases. 1. Mutation Phase 2. Protein Expression Phase 3. Plate Incorporation 4. Evaluation of Antibiotic Resistance - changes in MIC values to ciprofloxacin, tetracycline & erythromycin identified with Etest®. The AH26® demonstrated a log-fold increase in mutant rate compared to the spontaneous mutant rate. …

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Women's Roles In Fairy Tales: A Comparison Of The Portrayal Of Women In "Marienkind" Of The Brothers Grimm And Benedikte Naubert's "Ottilie"., Astrid Munder Jan 2002

Women's Roles In Fairy Tales: A Comparison Of The Portrayal Of Women In "Marienkind" Of The Brothers Grimm And Benedikte Naubert's "Ottilie"., Astrid Munder

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gender roles have always been and will always be, explicitly or implicitly, a topic of literature. The different ways in which gender roles are depicted in the literature of a given period reflect the political and societal state of affairs of that period. Literary works must therefore be critically analyzed to understand them in the context of their times. German fairy tales provide important examples of this. In this thesis I will examine the literary genre of the fairy tales in order to illustrate how differently female and male authors approached the topic of the woman’s role. To do so, …

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Progression Of Chronic Renal Disease In Several Animal Models: Possible Role Of Decreased Renal Nitric Oxide Production As A Primary Causative Factor., Aaron D. Erdely Jan 2002

Progression Of Chronic Renal Disease In Several Animal Models: Possible Role Of Decreased Renal Nitric Oxide Production As A Primary Causative Factor., Aaron D. Erdely

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chronic renal disease is the progressive loss of renal function that can lead to end-stage renal disease. Recent studies from our laboratory have shown decreased total NO production in patients with renal disease. Animal models have shown decreased total and renal NO production and chronic NOS inhibition in otherwise healthy rats causes renal injury. The overall objective in this set of studies was to investigate intrarenal NO production in various models of CRD and determine if NO deficiency parallels, and perhaps causes renal injury. In the first study, we report that normal male SD rats exhibit age-dependent declines in total …

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