Digital Commons Network^™

Investigating Birds As Dispersal Vectors Of Litylenchus Crenatae Subsp. Mccannii (Anguinidae), The Nematode Associated With Beech Leaf Disease, Spencer Rock Parkinson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Beech leaf disease (BLD) is an emerging forest pathogen primarily affecting American beech (Fagus grandifolia, Ehrh.) in North America and has been attributed to tree mortality of sapling sized trees within five to seven years of infection. Symptoms typically occur in regenerating American beech thickets sprouting from roots of trees killed by beech bark disease. Scientists first observed BLD in Ohio in 2012 and currently has spread to 15 states in the USA and one Canadian province. The nematode Litylenchus crenatae subsp. mccannii (Lcm) is highly associated with BLD symptoms, interveinal chlorosis and defoliation of leaves, and is currently …

Limb Speed Perception Accuracy In Neurodegenerative Disease, Brandmeir Lynn Cheryl

Graduate Theses, Dissertations, and Problem Reports (ETD)

Movement is a fundamental human activity, enabling us to engage with our surroundings. Consequently, a well-operating neuromuscular system is essential for maintaining quality of life. Motion is not only integral for the basic function of daily living, but also plays a significant role in enhancing our physical, mental, and emotional health. The importance of this system becomes abundantly clear when it is compromised, such as with neurodegenerative disease.

Alzheimer’s disease (AD), followed by Parkinson’s disease (PD) are the two most common neurodegenerative diseases that profoundly affect millions of individuals worldwide (Lamptey et al., 2022). Characterized by distinct but sometimes overlapping …

Bioenergy Cropping Systems Established On Marginal Lands: Effects Of Land Use, Energy Crop, And Fertility Amendments On Soil Health, Mica M. Keck

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bioenergy crops offer a promising strategy for renewable energy production, accompanied by carbon (C) storage benefits when managed sustainably. Utilizing marginal lands for energy feedstock production presents an opportunity for bioenergy generation and concurrent climate mitigation without competing with food crops. However, achieving optimal yields requires strategies to restore soil fertility, which require increased understanding of the interactive effects of prior land use, energy crop species, and fertility amendments available. This study, conducted as part of the Mid-Atlantic Sustainable Biomass (MASBio) Consortium, investigated the effects of biochar incorporation—a C-rich charcoal derived from biomass, intended for soil enhancement—on bioenergy cropping systems …

Analysis Of Mutations In Protein Kinase Ck2 Linked To Okur-Chung’S Neuropathy, Shivani Maan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The studies described here focus on mutations in protein kinase CK2 linked to ‘Okur-Chung’s Neuropathy’ (OCN), a neurodevelopmental disorder that involves 10 distinct mutations in the catalytic subunit CK2α. It has, however, remained unresolved if these mutations impair CK2α activity or if they also impair association with the regulatory CK2β subunit, which is necessary for assembly of the α2β2 holoenzyme. I describe efforts to resolve these questions for two mutations, Y50S and D175G. The former is thought to reside at the CK2α-CK2β interface, whereas the latter is located proximal to the active site. I therefore hypothesized that Y50S should perturb …

Zoo Communication: A Study Of Stewardship With Animal Conservation In Zoos Across The United States, Abby Rachelle Lester

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis investigates the communication strategies employed by zoo professionals to promote engagement and advanec animal conservation education. Through in-depth interviews with zoo experts, the stidy explores the intricate connections between communication practices and stewardship princliples within zoo facilities. Findings from this study contribute to the understanding of effective communication in the realm of animal conservation, with implications for both zoo practitioners and conservation educators. The study delves into the effective strategies for identifying and fostering relationships with environmental stewards, alongside encouraging their involvement in zoo-based animal conservation initiatives. The theoretical implications highlight gaps in existing models, emphasizing the need …

Estradiol’S Role In Timely Puberty Onset In The Ewe, Eliana Gerardine Aerts

Graduate Theses, Dissertations, and Problem Reports (ETD)

In female sheep, the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus triggers luteinizing hormone (LH) to be released from the pituitary. Luteinizing hormone, in turn, acts on the ovaries to elicit estradiol (E₂) release. E₂ acts in a negative feedback manner to control the amount of LH released. The increase in LH release that drives puberty onset results from a decrease in sensitivity to E₂ as the animal ages. However, the neural mechanisms mediating this change in sensitivity are not known, as is where in the hypothalamus E₂-negative feedback occurs. In the arcuate …

Transparent And Conductive Gallium Oxide Electrode For Simultaneous Recording And Optogenetic Stimulation, Christopher Patrick Carey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neural electrode technology has been around for centuries since the times of Galvani. In early electrophysiology experiments metal wires were used to induce contractions in dissected animals. The metal wire electrode has since been a standard tool to both stimulate and record neural activity. In the past two decades, a new strategy for neural stimulation has been formulated based on the emergent field of optogenetics. Optogenetics refers to the use of light-sensitive proteins genetically imbedded in the membrane of a neuron to elicit neural activity. This technique offers more selectivity in the stimulation of neurons. Typical optogenetic neural electrodes, or …

Machine Learning And Rna Bioinformatics, Jason Rafe Miller

Graduate Theses, Dissertations, and Problem Reports (ETD)

The applied science of bioinformatics encompasses computational analysis of molecular biology data. Advances in genomics and DNA sequencing technology have enabled computational analysis of ribonucleic acids (RNAs), which play diverse and critical roles in most cells. To assist the study of human RNA, we trained machine learning models on RNA nucleotide sequences, devoid of domain knowledge. We built models that distinguish long non-coding lncRNA from protein-coding mRNA, and models that predict the cytoplasmic vs. nuclear preferences of lncRNAs. In a review of published lncRNA subcellular localization classifiers, we show that the commonly used validation protocol generates optimistic performance measures, and …

Hacking The Library Exhibition Panels, Sally Brown, Jackie Andrews, Matthew Conboy, Ruth Yang, Trudy Trudy Borenstein- Sugiura, Shan Cawley, Chantel Foretich, Xue'er Gao, Ryan Lewis, Robin Miller, Imari Nacht, Chris Revelle, Erin Tapley

Faculty & Staff Scholarship

The hacker ethos in the positive sense is about the ability to deconstruct and reconstruct information systems. Hacking starts with reconceptualizing libraries. Libraries are now beyond the book. As libraries evolve into a new sort of space --still a space for research, learning and study-- but also for community engagement and collaboration, library exhibits present a unique opportunity for both collaborating exhibitors and library users. Artists engage with libraries creatively through artist residencies, installations, using discarded library materials in their work, collaborative workshops, digital collections remixing, performances and more. Hacking the Library will present artwork that highlights the intersecting values …

Ryan Lewis Panel, Ryan Lewis

Hacking the Library

No abstract provided.

Hacking The Library Exhibition Designs, Karen Diaz

Hacking the Library

The hacker ethos in the positive sense is about the ability to deconstruct and reconstruct information systems. Hacking starts with reconceptualizing libraries. Libraries are now beyond the book. As libraries evolve into a new sort of space --still a space for research, learning and study-- but also for community engagement and collaboration, library exhibits present a unique opportunity for both collaborating exhibitors and library users. Artists engage with libraries creatively through artist residencies, installations, using discarded library materials in their work, collaborative workshops, digital collections remixing, performances and more. Hacking the Library will present artwork that highlights the intersecting values …

Hacking The Library Exhibition Pdfs, Sally Brown, Christine Hoffmann, Lois Ann Raimondo, Karen Diaz, Sarah Pahlfrey

Faculty & Staff Scholarship

The hacker ethos in the positive sense is about the ability to deconstruct and reconstruct information systems. Hacking starts with reconceptualizing libraries. L Hacking the Library presents artwork that highlights the intersecting values that shape our libraries through an artistic lens, reflecting on challenges and definitions of libraries past and as we move into the future. To provide personal context, "Community Connections" complement the art from librarians across the nation who responded to the artwork.

Artists included: Jackie Andrews (Maryland, mixed media), Trudy Borenstein- Sugiura (New Jersey, book arts), Sally Jane Brown (West Virginia, drawing), Shan Cawley (West Virginia, painting), …

Solutions For Heirs Property Owners, Jesse J. Richardson Jr., Amber S. Miller

Law Faculty Scholarship

What are some solutions for heirs property owners? An offered solution assumes that there is a problem, and the first step must be clearly defining the problem. But, as the authors explain, the term "heirs property" proves difficult to define because of the vast number and scope of heirs property scenarios. Stated very simply, the term refers to a subset of tenancy in common property where the owners received concurrent interests in land through inheritance. But, heirs property is anything but simple. In fact, it is quite complex, beginning with the ownership picture of heirs property tracts of land: the …

Strawberry Soju, Linda Ma

Calliope

No abstract provided.

Full Issue

Calliope

No abstract provided.

Unfairy Tales And Other Refugee Stories: Creating Relations Through The Humanitarian Imagination In Mohsin Hamid's Exit West And Helen Oyeyemi's Gingerbread, Gabriella Pishotti

Graduate Student Scholarship

Contrary to many analyses of refugee narratives that focus on how their subject matter becomes compromised by issues of authority, believability, and expectation, this article explores how refugee novels such as Mohsin Hamid's Exit West and Helen Oyeyemi's Gingerbread lean into such problems in a way that appeals to the humanitarian imagination. These novels recognize the incomprehensibility of the refugee experience and play upon this reality by intermixing their stories with fairy tale elements. In doing so, the tropes of fairy tales provide these stories with greater narrative flexibility while making the unfamiliar realities of refugees comprehensible through familiar narrative …

Banned Or Grand?: Why Graphic Novels Maus And Persepolis Belong In The Classroom, Lauren Volk

Munn Scholars Awards

My capstone essay, “Banned or Grand?: Why Graphic Novels Maus and Persepolis Belong in The Classroom,” seeks to research both the objections to oft-banned memoir graphic novels being incorporated in the secondary school curriculum and the reasons why these graphic novels should not only be incorporated into the curriculum, but also why they assist students in developing necessary skills, such as higher-level critical thinking, a deeper understanding of complicated historical events, and the analysis of form and structure in literature, rather than just content. To enhance my research, I connected my main points to the pedagogical theory of learning transfer.

The Censorship Constraint And Rulemaker State Action: Are Section 230'S Immunity Provisions Unconstitutional Content-Based Regulations?, Scot A. Reader

West Virginia Law Review

Even casual watchers of T.V. crime dramas understand the Fourth Amendment’s exclusionary rule. Under this rule, evidence obtained by the police in a search of a criminal suspect’s premises that exceeds the scope of a judicial warrant is almost always inadmissible in the suspect’s criminal trial. The rule is designed to deter unreasonable governmental intrusion into private affairs and applies without regard for the suspect’s guilt or innocence. This Article proposes that the First Amendment includes an analogous rule against governmental censorship. Under this rule, content-based speech regulations exceed the legislature’s speech rulemaking warrant and are almost always invalid. This …

Certifiably Employable?: The Effects Of Occupational Regulation On Unemployment Duration, Ilya Kukaev, Edward Timmons

Economics Faculty Working Papers Series

Occupational regulation is a labor market institution that has received a growing amount of attention by researchers. Existing research has explored the effects of occupational regulation on wages and employment. To the best of our knowledge, no existing study has estimated the effect of occupational credentials on unemployment duration in the US. We derive a random search model to explain differences in individual unemployment duration resulting from heterogeneous effects from licenses and certificates. Our model predicts that an occupational credential with a stronger signaling or human capital effect results in a shorter individual unemployment duration. To estimate the effect of …

Food, Freedom, Fairness, And The Family Farm, Robin Rotman, Sophie Mendelson

West Virginia Law Review

The concept of the “family farm” holds powerful sway within the American narrative, embodying both nostalgia for an imagined past and anxiety for a future perceived to be under threat. Since the founding of the United States, this cultural ideal has been invoked in support of a rosy vision of agrarian democracy while obscuring the ways in which the U.S. Department of Agriculture’s codified definition of “family farm” has unfairly aggregated advantages for the benefit of a particular kind of family (nuclear) and farmer (white, male, straight). At the same time, consumers are misled by an under-interrogated conflation of family …

Special Collections As Muse: The Use Of Rare Books And Archives To Inspire Creative Works, Tracy Grimm, Adriana Harmeyer

Faculty & Staff Scholarship

The unique and varied collections held by archives and special collections within many academic libraries offer fertile ground for the creative endeavors of students, faculty, and professional artists. This chapter explores direct and indirect methods librarians and archivists may engage creators with primary source materials. Academic libraries do not necessarily need to build art-focused collections in order to support the research of creators. More than subject content, successful engagement with creators is developed by means of collaborative relationships with arts faculty, artists, and galleries to reach student creators and introduce concepts of primary source research as a source of inspiration. …

Construct An Anaerobic Digester To Treat West Virginia University’S Food Waste, Kevin Omer

Bridge Initiative for Science and Technology Policy, Leadership, and Communications

West Virginia University (WVU) should construct an anaerobic digester to dispose of the approximately 175 tons of food waste generated each year. Today, this waste is transported to a landfill 50 miles away, impacting the environment in a way that is not consistent with WVU’s sustainability policy. A digester, which uses bacteria to turn food waste into biogas, can reduce WVU’s greenhouse gas emissions and other environmental impacts. In addition, faculty can use the digester to conduct research and teach sustainable practices that can be used throughout the state once students graduate. Further, prospective students often review a university’s sustainability …

Detection And Observed Correlations Of Statin And Beta-Blocking Pharmaceuticals In West Virginia Surface Waters And Ichthyofauna, Joseph W. Kingsbury

Graduate Theses, Dissertations, and Problem Reports (ETD)

Within this thesis the source, presence, and the estimated ecotoxicological effects of cardiovascular medicines, specifically statins and beta-blockers are described within the Buckhannon, Tygart Valley, and West Fork Rivers of West Virginia. Included within this thesis is a general introduction providing key background information and relevant research related to the source, presence, and known toxicity of statins and beta-blockers. Following the general introduction there are 3 distinct chapters. Chapter 1 focuses on the estimated demographic based source loadings and the surface water concentration characteristics of statins and beta-blockers within the three rivers. Chapter 2 investigates the effects of statins and …

Object Detection And Classification In The Visible And Infrared Spectrums, Domenick D. Poster

Graduate Theses, Dissertations, and Problem Reports (ETD)

The over-arching theme of this dissertation is the development of automated detection and/or classification systems for challenging infrared scenarios. The six works presented herein can be categorized into four problem scenarios. In the first scenario, long-distance detection and classification of vehicles in thermal imagery, a custom convolutional network architecture is proposed for small thermal target detection. For the second scenario, thermal face landmark detection and thermal cross-spectral face verification, a publicly-available visible and thermal face dataset is introduced, along with benchmark results for several landmark detection and face verification algorithms. Furthermore, a novel visible-to-thermal transfer learning algorithm for face landmark …

Advancing Assessments Of Climate Change Vulnerability Of West Virginia Watersheds, Joseph T. Molina

Graduate Theses, Dissertations, and Problem Reports (ETD)

As climate change is becoming increasingly recognized as a threat to aquatic ecosystems, climate adaptation planning, in both the long- and short-term, is becoming more common in natural resource management. There is a need within conservation agencies to develop methodologies and assessments that support adaptation planning to efficiently disperse conservation dollars and effectively strengthen ecological and community resilience as climate changes continue. My thesis aims to provide West Virginia natural resources managers with climate vulnerability assessments that can be used to determine where and how conservation efforts should be administered. Additionally, I demonstrate a methodology that can be built upon …

Specialized Metabolism In Retina, Retinal Pigmented Epithelium, And Testis, Siyan Zhu

Graduate Theses, Dissertations, and Problem Reports (ETD)

The retina and its neighboring retinal pigmented epithelium (RPE) are high energy-demanding and metabolically active tissues with specialized and complementary metabolism. They are metabolically interdependent and impact each other’s viability. Interestingly, many of the metabolic features in the retina and RPE are shared with the testis. For example, testis is also energy costly due to continuous sperm differentiation and it has similar metabolic inter-dependence between different testis cells. Both the retina and testis are vulnerable to mitochondrial metabolic impairments.

We conducted three research projects to understand 1) the nutrient utilization and communication in retina and RPE; 2) The profiling of …

Leveraging Data Science To Promote Sustainable Resource Recovery From Organic Waste Streams In Rural Regions, Mohammed Tamim Zaki

Graduate Theses, Dissertations, and Problem Reports (ETD)

Conventional organic waste management practices such as landfilling contribute to global warming and degrade environmental and human health. Alternatively, organic waste can be treated to recover energy, nutrients, and carbon through resource recovery technologies. Data science could benefit such technologies by improving their efficiency through data-driven process modeling along with reducing environmental and economic burdens via life cycle assessment (LCA) and techno-economic analysis (TEA), respectively.

A critical review of 616 peer-reviewed articles published during 2002–2022 was conducted on the use of data science methods in resource recovery from organic waste. Although applications of machine learning (ML) methods have drastically increased …

Conditioned Reinforcement By Stimuli Correlated And Uncorrelated With A Schedule Of Food Reinforcement, Lillian L. Skiba-Thayer

Graduate Theses, Dissertations, and Problem Reports (ETD)

A conditioned reinforcer derives its function from a relation to an established reinforcer. Respondent views suggest that a stimulus acquires reinforcing properties because it is positively correlated with an established reinforcer. Alternatively, the information hypothesis suggests that a stimulus acquires reinforcing properties because it reduces uncertainty about the likelihood of an established reinforcer. Observing response procedures have been used to evaluate the function of stimuli positively correlated (S+), negatively correlated (S-), and uncorrelated (S1, S2) with established reinforcers such as food (with animals) or money (with humans). Verbal instructions have been shown to alter the extent to which correlated and …

Right Treatment Wrong Time: Immunotherapy Administration Post-Radiotherapy Decreases Tumor Burden In A Preclinical Model Of Brain Metastasis, Kathryn Elizabeth Blethen

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation (a) provided an in-depth literature review of methods to modulate the blood-brain and blood-tumor barriers to increase drug delivery and efficacy in brain metastases, (b) evaluated the effects of whole-brain radiation therapy on the blood-brain barrier in immunocompetent and immunocompromised mouse models and proposed a mechanism by which the immune response to radiation disrupts the blood-brain barrier, and (c) developed a syngeneic lung cancer brain metastasis model to determine the impact of coordinated immunotherapy administration with radiotherapy. The blood-brain barrier is an impediment to drug delivery to the brain. The inherent leakiness of the blood-tumor barrier does not …

Elucidation Of The Role Of Agouti-Signaling Protein Throughout Folliculogenesis And Early Embryonic Development In Cattle, Heather L. Chaney

Graduate Theses, Dissertations, and Problem Reports (ETD)

The oocyte expresses certain genes during folliculogenesis to regulate the acquisition of oocyte competence. Oocyte competence, which refers to the presence of imperative molecular factors in the oocyte that are critical for high oocyte quality, is directly related to the ability of the oocyte to result in a successful pregnancy following fertilization. Over the past few decades, the development and optimization of assisted reproductive technologies, particularly in vitrofertilization, have enabled the beef and dairy industries to advance cattle genetics and productivity. However, only approximately 40% of bovine embryos will develop to the blastocyst stage in vitro. In addition, bovine embryos …