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Washington University School of Medicine

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Human Primary Macrophages Derived In Vitro From Circulating Monocytes Comprise Adherent And Non-Adherent Subsets With Differential Expression Of Siglec-1 And Cd4 And Permissiveness To Hiv-1 Infection, Ousman Jobe, Jiae Kim, Eric Tycksen, Sayali Onkar, Nelson L. Michael, Carl R. Alving, Mangala Rao Jan 2017

Human Primary Macrophages Derived In Vitro From Circulating Monocytes Comprise Adherent And Non-Adherent Subsets With Differential Expression Of Siglec-1 And Cd4 And Permissiveness To Hiv-1 Infection, Ousman Jobe, Jiae Kim, Eric Tycksen, Sayali Onkar, Nelson L. Michael, Carl R. Alving, Mangala Rao

Open Access Publications

No abstract provided.


Dna2 Initiates Resection At Clean Dna Double-Strand Breaks, Sharad C. Paudyal, Shan Li, Hong Yan, Tony Hunter, Zhongsheng You Jan 2017

Dna2 Initiates Resection At Clean Dna Double-Strand Breaks, Sharad C. Paudyal, Shan Li, Hong Yan, Tony Hunter, Zhongsheng You

Open Access Publications

No abstract provided.


Wormbase 2017: Molting Into A New Stage, Tim Schedl, Et Al Jan 2017

Wormbase 2017: Molting Into A New Stage, Tim Schedl, Et Al

Open Access Publications

No abstract provided.


On The Path To 2025: Understanding The Alzheimer’S Disease Continuum, Paul S. Aisen, Jeffrey Cummings, Clifford R. Jack Jr, John C. Morris, Reisa Sperling, Lutz Frölich, Roy W. Jones, Sherie A. Dowsett, Brandy R. Matthews, Joel Raskin, Philip Scheltens, Bruno Dubois Jan 2017

On The Path To 2025: Understanding The Alzheimer’S Disease Continuum, Paul S. Aisen, Jeffrey Cummings, Clifford R. Jack Jr, John C. Morris, Reisa Sperling, Lutz Frölich, Roy W. Jones, Sherie A. Dowsett, Brandy R. Matthews, Joel Raskin, Philip Scheltens, Bruno Dubois

Open Access Publications

No abstract provided.


A Sensitive Assay Reveals Structural Requirements For Α-Synuclein Fibril Growth, Dhruva D. Dhavale, Christina Tsai, Devika P. Bagchi, Laura A. Engel, Jonathan Sarezky, Paul T. Kotzbauer Jan 2017

A Sensitive Assay Reveals Structural Requirements For Α-Synuclein Fibril Growth, Dhruva D. Dhavale, Christina Tsai, Devika P. Bagchi, Laura A. Engel, Jonathan Sarezky, Paul T. Kotzbauer

Open Access Publications

No abstract provided.


Modulation Of Tmem16a Channel Activity By The Von Willebrand Factor Type A (Vwa) Domain Of The Calcium-Activated Chloride Channel Regulator 1 (Clca1), Monica Sala-Rabanal, Zeynep Yurtsever, Kayla N. Berry, Colin G. Nichols, Tom J. Brett Jan 2017

Modulation Of Tmem16a Channel Activity By The Von Willebrand Factor Type A (Vwa) Domain Of The Calcium-Activated Chloride Channel Regulator 1 (Clca1), Monica Sala-Rabanal, Zeynep Yurtsever, Kayla N. Berry, Colin G. Nichols, Tom J. Brett

Open Access Publications

No abstract provided.


Selinexor Overcomes Hypoxia-Induced Drug Resistance In Multiple Myeloma, Barbara Muz, Feda Azab, Pilar De La Puente, Yosef Landesman, Abdel Kareem Azab Jan 2017

Selinexor Overcomes Hypoxia-Induced Drug Resistance In Multiple Myeloma, Barbara Muz, Feda Azab, Pilar De La Puente, Yosef Landesman, Abdel Kareem Azab

Open Access Publications

No abstract provided.


Epithelial Chloride Transport By Cftr Requires Tmem16a, Roberta Benedetto, Jiraporn Ousingsawat, Podchanart Wanitchakool, Yong Zhang, Michael J. Holtzman, Margarida Amaral, Jason R. Rock, Rainer Schreiber, Karl Kunzelmann Jan 2017

Epithelial Chloride Transport By Cftr Requires Tmem16a, Roberta Benedetto, Jiraporn Ousingsawat, Podchanart Wanitchakool, Yong Zhang, Michael J. Holtzman, Margarida Amaral, Jason R. Rock, Rainer Schreiber, Karl Kunzelmann

Open Access Publications

No abstract provided.


Targeting The Tumor-Promoting Microenvironment In Met-Amplified Nsclc Cells With A Novel Inhibitor Of Pro-Hgf Activation, Benjamin Y. Owusu, Shantasia Thomas, Phanindra Venukadasula, Zhenfu Han, James W. Janetka, Robert A. Galemmo Jr, Lidija Klampfer Jan 2017

Targeting The Tumor-Promoting Microenvironment In Met-Amplified Nsclc Cells With A Novel Inhibitor Of Pro-Hgf Activation, Benjamin Y. Owusu, Shantasia Thomas, Phanindra Venukadasula, Zhenfu Han, James W. Janetka, Robert A. Galemmo Jr, Lidija Klampfer

Open Access Publications

No abstract provided.


Long-Term Deficits In Cortical Circuit Function After Asphyxial Cardiac Arrest And Resuscitation In Developing Rats, Jason W. Middleton, Daniel J. Simons, Jennifer W. Simmons, Robert S.B. Clark, Patrick M. Kochanek, Michael Shoykhet Jan 2017

Long-Term Deficits In Cortical Circuit Function After Asphyxial Cardiac Arrest And Resuscitation In Developing Rats, Jason W. Middleton, Daniel J. Simons, Jennifer W. Simmons, Robert S.B. Clark, Patrick M. Kochanek, Michael Shoykhet

Open Access Publications

No abstract provided.


Parkinsonian Motor Impairment Predicts Personality Domains Related To Genetic Risk And Treatment Outcomes In Schizophrenia, Juan L. Molina, María Calvó, Eduardo Padilla, Mara Balda, Gabriela González Alemán, Néstor V. Florenzano, Gonzalo Guerrero, Danielle Kamis, Beatriz Molina Rangeon, Mercedes Bourdieu, Sergio A. Strejilevich, Horacio A. Conesa, Javier I. Escobar, Igor Zwir, C. Robert Cloninger, Gabriel A. De Erausquin Jan 2017

Parkinsonian Motor Impairment Predicts Personality Domains Related To Genetic Risk And Treatment Outcomes In Schizophrenia, Juan L. Molina, María Calvó, Eduardo Padilla, Mara Balda, Gabriela González Alemán, Néstor V. Florenzano, Gonzalo Guerrero, Danielle Kamis, Beatriz Molina Rangeon, Mercedes Bourdieu, Sergio A. Strejilevich, Horacio A. Conesa, Javier I. Escobar, Igor Zwir, C. Robert Cloninger, Gabriel A. De Erausquin

Open Access Publications

No abstract provided.


Organization Of The Dorsal Lateral Geniculate Nucleus In The Mouse, Daniel Kerschensteiner, William Guido Jan 2017

Organization Of The Dorsal Lateral Geniculate Nucleus In The Mouse, Daniel Kerschensteiner, William Guido

Open Access Publications

No abstract provided.


Notch Signaling Regulates Metabolic Heterogeneity In Glioblastoma Stem Cells, Sheng Si, Et Al Jan 2017

Notch Signaling Regulates Metabolic Heterogeneity In Glioblastoma Stem Cells, Sheng Si, Et Al

Open Access Publications

No abstract provided.


A Rare Case Of Renal Thrombotic Microangiopathy Associated With Castleman’S Disease, Ahubha Mutneja, L. Nicholas Cossey, Helen Liapis, Ying Maggie Chen Jan 2017

A Rare Case Of Renal Thrombotic Microangiopathy Associated With Castleman’S Disease, Ahubha Mutneja, L. Nicholas Cossey, Helen Liapis, Ying Maggie Chen

Open Access Publications

No abstract provided.


A Single Transcription Factor Is Sufficient To Induce And Maintain Secretory Cell Architecture, Hei-Yong G. Lo, Ramon U. Jin, Greg Sibbel, Dengqun Liu, Anju Karki, Matthew S. Joens, Blair B. Madison, Bo Zhang, Valerie Blanc, James A.J. Fitzpatrick, Nicholas O. Davidson, Stephen F. Konieczny, Jason C. Mills Jan 2017

A Single Transcription Factor Is Sufficient To Induce And Maintain Secretory Cell Architecture, Hei-Yong G. Lo, Ramon U. Jin, Greg Sibbel, Dengqun Liu, Anju Karki, Matthew S. Joens, Blair B. Madison, Bo Zhang, Valerie Blanc, James A.J. Fitzpatrick, Nicholas O. Davidson, Stephen F. Konieczny, Jason C. Mills

Open Access Publications

No abstract provided.


A Postnatal Role For Embryonic Myosin Revealed By Myh3 Mutations That Alter Tgfβ Signaling And Cause Autosomal Dominant Spondylocarpotarsal Synostosis, Dorothy K. Grange, Et Al Jan 2017

A Postnatal Role For Embryonic Myosin Revealed By Myh3 Mutations That Alter Tgfβ Signaling And Cause Autosomal Dominant Spondylocarpotarsal Synostosis, Dorothy K. Grange, Et Al

Open Access Publications

No abstract provided.


Mavs Is Essential For Primary Cd4 + T Cell Immunity But Not For Recall T Cell Responses Following An Attenuated West Nile Virus Infection, Huanle Luo, Evandro Winkelmann, Guorui Xie, Rong Fang, Bi-Hung Peng, Li Li, Helen M. Lazear, Slobodan Paessler, Michael S. Diamond, Michael Gale Jr, Alan D. Barrett, Tian Wang Jan 2017

Mavs Is Essential For Primary Cd4 + T Cell Immunity But Not For Recall T Cell Responses Following An Attenuated West Nile Virus Infection, Huanle Luo, Evandro Winkelmann, Guorui Xie, Rong Fang, Bi-Hung Peng, Li Li, Helen M. Lazear, Slobodan Paessler, Michael S. Diamond, Michael Gale Jr, Alan D. Barrett, Tian Wang

Open Access Publications

No abstract provided.


Human Embryos Cultured In Vitro To 14 Days, Samantha A. Morris Jan 2017

Human Embryos Cultured In Vitro To 14 Days, Samantha A. Morris

Open Access Publications

No abstract provided.


The Role Of Cdc1s In Vivo: Cd8 T Cell Priming Through Cross-Presentation [Version 1; Referees: 3 Approved], Derek Theisen, Kenneth Murphy Jan 2017

The Role Of Cdc1s In Vivo: Cd8 T Cell Priming Through Cross-Presentation [Version 1; Referees: 3 Approved], Derek Theisen, Kenneth Murphy

Open Access Publications

No abstract provided.


Topoisomerase Ii Inhibitors Induce Dna Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion, Priya Luthra, Sebastian Aguirre, Benjamin C. Yen, Colette A. Pietzsch, Maria T. Sanchez-Aparicio, Bersabeh Tigabu, Lorraine K. Morlock, Adolfo Garcia-Sastre, Daisy W. Leung, Noelle S. Williams, Ana Fernandez-Sesma, Alexander Bukreyev, Christopher F. Basler Jan 2017

Topoisomerase Ii Inhibitors Induce Dna Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion, Priya Luthra, Sebastian Aguirre, Benjamin C. Yen, Colette A. Pietzsch, Maria T. Sanchez-Aparicio, Bersabeh Tigabu, Lorraine K. Morlock, Adolfo Garcia-Sastre, Daisy W. Leung, Noelle S. Williams, Ana Fernandez-Sesma, Alexander Bukreyev, Christopher F. Basler

Open Access Publications

No abstract provided.


A C3(H20) Recycling Pathway Is A Component Of The Intracellular Complement System, Michelle Elvington, M. Kathryn Liszewski, Paula Bertram, Hrishikesh S. Kulkarni, John P. Atkinson Jan 2017

A C3(H20) Recycling Pathway Is A Component Of The Intracellular Complement System, Michelle Elvington, M. Kathryn Liszewski, Paula Bertram, Hrishikesh S. Kulkarni, John P. Atkinson

Open Access Publications

No abstract provided.


Evolution Of The Hypoxia-Sensitive Cells Involved In Amniote Respiratory Reflexes, Charles K. Kaufman, Et Al Jan 2017

Evolution Of The Hypoxia-Sensitive Cells Involved In Amniote Respiratory Reflexes, Charles K. Kaufman, Et Al

Open Access Publications

No abstract provided.


A Phase 1 Dose-Escalation And Expansion Study Of Binimetinib (Mek162), A Potent And Selective Oral Mek1/2 Inhibitor, Benjamin R. Tan, Et Al Jan 2017

A Phase 1 Dose-Escalation And Expansion Study Of Binimetinib (Mek162), A Potent And Selective Oral Mek1/2 Inhibitor, Benjamin R. Tan, Et Al

Open Access Publications

No abstract provided.


Phospholipase Cγ1 (Plcγ1) Controls Osteoclast Numbers Via Colony-Stimulating Factor 1 (Csf-1)-Dependent Diacylglycerol/Β-Catenin/Cyclind1 Pathway, Zhengfeng Yang, Seokho Kim, Sahil Mahajan, Ali Zamani, Roberta Faccio Jan 2017

Phospholipase Cγ1 (Plcγ1) Controls Osteoclast Numbers Via Colony-Stimulating Factor 1 (Csf-1)-Dependent Diacylglycerol/Β-Catenin/Cyclind1 Pathway, Zhengfeng Yang, Seokho Kim, Sahil Mahajan, Ali Zamani, Roberta Faccio

Open Access Publications

No abstract provided.


Engineering Of Glcnac-1-Phosphotransferase For Production Of Highly Phosphorylated Lysosomal Enzymes For Enzyme Replacement Therapy, Lin Liu, Wang-Sik Lee, Balraj Doray, Stuart Kornfeld Jan 2017

Engineering Of Glcnac-1-Phosphotransferase For Production Of Highly Phosphorylated Lysosomal Enzymes For Enzyme Replacement Therapy, Lin Liu, Wang-Sik Lee, Balraj Doray, Stuart Kornfeld

Open Access Publications

No abstract provided.


Genome Engineering Of Stem Cells For Autonomously Regulated, Closed-Loop Delivery Of Biologic Drugs, Jonathan M. Brunger, Ananya Zutshi, Vincent P. Willard, Charles A. Gersbach, Farshid Guilak Jan 2017

Genome Engineering Of Stem Cells For Autonomously Regulated, Closed-Loop Delivery Of Biologic Drugs, Jonathan M. Brunger, Ananya Zutshi, Vincent P. Willard, Charles A. Gersbach, Farshid Guilak

Open Access Publications

No abstract provided.


Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears In A Small Animal Model, Adam Z. Khan, Et Al Jan 2017

Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears In A Small Animal Model, Adam Z. Khan, Et Al

Open Access Publications

No abstract provided.


Loss Of Navβ4-Mediated Regulation Of Sodium Currents In Adult Purkinje Neurons Disrupts Firing And Impairs Motor Coordination And Balance, Joseph L. Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L. Donermeyer, Paul M. Allen, Jeanne M. Nerbonne Jan 2017

Loss Of Navβ4-Mediated Regulation Of Sodium Currents In Adult Purkinje Neurons Disrupts Firing And Impairs Motor Coordination And Balance, Joseph L. Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L. Donermeyer, Paul M. Allen, Jeanne M. Nerbonne

Open Access Publications

No abstract provided.


Research Priorities In Limb And Task-Specific Dystonias, Sarah Pirio Richardson, Eckart Altenmüller, Katharine Alter, Ron L. Alterman, Robert Chen, Steven Frucht, Shinichi Furuya, Joseph Jankovic, H.A. Jinnah, Teresa J. Kimberley, Codrin Lungu, Joel S. Perlmutter, Cecilia N. Prudente, Mark Hallett Jan 2017

Research Priorities In Limb And Task-Specific Dystonias, Sarah Pirio Richardson, Eckart Altenmüller, Katharine Alter, Ron L. Alterman, Robert Chen, Steven Frucht, Shinichi Furuya, Joseph Jankovic, H.A. Jinnah, Teresa J. Kimberley, Codrin Lungu, Joel S. Perlmutter, Cecilia N. Prudente, Mark Hallett

Open Access Publications

No abstract provided.


Inhibitory Control Of Feature Selectivity In An Object Motion Sensitive Circuit Of The Retina, Tahnbee Kim, Daniel Kerschensteiner Jan 2017

Inhibitory Control Of Feature Selectivity In An Object Motion Sensitive Circuit Of The Retina, Tahnbee Kim, Daniel Kerschensteiner

Open Access Publications

No abstract provided.