Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (3862)
- Life Sciences (6)
- Rehabilitation and Therapy (6)
- Physical Therapy (4)
- Bioinformatics (2)
-
- Mental and Social Health (2)
- Occupational Therapy (2)
- Social and Behavioral Sciences (2)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biology (1)
- Biostatistics (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Communication (1)
- Exercise Science (1)
- Gerontology (1)
- Kinesiology (1)
- Kinesiotherapy (1)
- Medical Specialties (1)
- Microbiology (1)
- Nursing (1)
- Nutrition (1)
- Obstetrics and Gynecology (1)
- Physical Sciences and Mathematics (1)
- Physiology (1)
- Psychiatry and Psychology (1)
- Sociology (1)
- Sports Sciences (1)
- Statistics and Probability (1)
- Keyword
-
- Humans (1944)
- ICTS (Institute of Clinical and Translational Sciences) (1873)
- Animals (1062)
- Female (805)
- Mice (729)
-
- Male (704)
- Adult (363)
- Middle Aged (342)
- Aged (306)
- Mice, Inbred C57BL (171)
- Child (163)
- Brain (159)
- Mutation (148)
- Disease Models, Animal (138)
- Mice, Knockout (122)
- Psychiatry (121)
- Adolescent (119)
- Young Adult (115)
- COVID-19 (113)
- Alzheimer Disease (106)
- Signal Transduction (105)
- Neoplasms (100)
- Aged, 80 and over (97)
- Biomarkers (97)
- SARS-CoV-2 (94)
- Phenotype (87)
- Cell Line, Tumor (86)
- United States (86)
- Risk Factors (84)
- Neurons (83)
- Publication Year
- Publication
-
- Open Access Publications (5949)
- 2020-Current year OA Pubs (2808)
- Washington University Record (1125)
- Outlook Magazine (173)
- Washington University Magazine (165)
-
- Washington University School of Medicine Bulletins (113)
- Focal Spot All Issues (112)
- BJC Today (95)
- 216 Jewish Hospital (77)
- Barnes Hospital Bulletin (68)
- ICTS Faculty Publications (41)
- Posters (41)
- Independent Studies and Capstones (37)
- Washington University Medical Alumni Quarterly (34)
- 2010-2019 OA Pubs (29)
- BCL Progress Reports (24)
- PACS News (21)
- Children’s Hospital Magazine (15)
- Presentations (14)
- Becker Library Publications and Presentations (13)
- WUSM Theses and Dissertations – All Programs (13)
- ICTS Newsletters (11)
- Barnes Hospital Record (10)
- Occupational and Health Faculty Publications (8)
- Psychiatry Faculty Publications (8)
- The Hatchet (8)
- Human Research Protection Program (HRPP) Education (7)
- Library Annual Reports (6)
- Washington University School of Medicine Histories (6)
- HRPO Publications (5)
- Publication Type
Articles 5251 - 5280 of 11087
Full-Text Articles in Entire DC Network
Pediatric And Adult Dilated Cardiomyopathy Represent Distinct Pathological Entities, Meghna D. Patel, Jayaram Mohan, Caralin Schneider, Geetika Bajpai, Enkhsaikhan Purevjav, Charles E. Canter, Jeffrey Towbin, Andrea Bredemeyer, Kory J. Lavine
Pediatric And Adult Dilated Cardiomyopathy Represent Distinct Pathological Entities, Meghna D. Patel, Jayaram Mohan, Caralin Schneider, Geetika Bajpai, Enkhsaikhan Purevjav, Charles E. Canter, Jeffrey Towbin, Andrea Bredemeyer, Kory J. Lavine
Open Access Publications
Pediatric dilated cardiomyopathy (DCM) is the most common indication for heart transplantation in children. Despite similar genetic etiologies, medications routinely used in adult heart failure patients do not improve outcomes in the pediatric population. The mechanistic basis for these observations is unknown. We hypothesized that pediatric and adult DCM comprise distinct pathological entities, in that children do not undergo adverse remodeling, the target of adult heart failure therapies. To test this hypothesis, we examined LV specimens obtained from pediatric and adult donor controls and DCM patients. Consistent with the established pathophysiology of adult heart failure, adults with DCM displayed marked …
Ca2+-Permeable Ampars Mediate Glutamatergic Transmission And Excitotoxic Damage At The Hair Cell Ribbon Synapse, Joy Y. Sebe, Soyoun Cho, Lavinia Sheets, Mark A. Rutherford, Henrique Von Gersdorff, David W. Raible
Ca2+-Permeable Ampars Mediate Glutamatergic Transmission And Excitotoxic Damage At The Hair Cell Ribbon Synapse, Joy Y. Sebe, Soyoun Cho, Lavinia Sheets, Mark A. Rutherford, Henrique Von Gersdorff, David W. Raible
Open Access Publications
We report functional and structural evidence for GluA2-lacking Ca
Genomic Landscape And Evolution Of Metastatic Chromophobe Renal Cell Carcinoma, Jozefina Casuscelli, James J. Hsieh, Et Al
Genomic Landscape And Evolution Of Metastatic Chromophobe Renal Cell Carcinoma, Jozefina Casuscelli, James J. Hsieh, Et Al
Open Access Publications
Chromophobe renal cell carcinoma (chRCC) typically shows ~7 chromosome losses (1, 2, 6, 10, 13, 17, and 21) and ~31 exonic somatic mutations, yet carries ~5%-10% metastatic incidence. Since extensive chromosomal losses can generate proteotoxic stress and compromise cellular proliferation, it is intriguing how chRCC, a tumor with extensive chromosome losses and a low number of somatic mutations, can develop lethal metastases. Genomic features distinguishing metastatic from nonmetastatic chRCC are unknown. An integrated approach, including whole-genome sequencing (WGS), targeted ultradeep cancer gene sequencing, and chromosome analyses (FACETS, OncoScan, and FISH), was performed on 79 chRCC patients including 38 metastatic (M-chRCC) …
Early Detection Of Gastric Cancer Using Global, Genome-Wide And Irf4, Elmo1, Clip4 And Msc Dna Methylation In Endoscopic Biopsies, Francesca Pirini, Douglas E. Berg, Et Al
Early Detection Of Gastric Cancer Using Global, Genome-Wide And Irf4, Elmo1, Clip4 And Msc Dna Methylation In Endoscopic Biopsies, Francesca Pirini, Douglas E. Berg, Et Al
Open Access Publications
Clinically useful molecular tools to triage gastric cancer patients are not currently available. We aimed to develop a molecular tool to predict gastric cancer risk in endoscopy-driven biopsies obtained from high-risk gastric cancer clinics in low resource settings.We discovered and validated a DNA methylation biomarker panel in endoscopic samples obtained from 362 patients seen between 2004 and 2009 in three high-risk gastric cancer clinics in Lima, Perú, and validated it in 306 samples from the Cancer Genome Atlas project ("TCGA"). Global, epigenome wide and gene-specific DNA methylation analyses were used in a Phase I Biomarker Development Trial to identify a …
Gastrointestinal Stromal Tumors (Gists): Point Mutations Matter In Management, A Review, Peter J. Oppelt, Angela C. Hirbe, Brian A. Van Tine
Gastrointestinal Stromal Tumors (Gists): Point Mutations Matter In Management, A Review, Peter J. Oppelt, Angela C. Hirbe, Brian A. Van Tine
Open Access Publications
The therapeutic implications of the genomic alterations seen within the drivers of gastrointestinal stromal tumors (GIST) are among the best understood in all of solid tumors. Sequencing of cKIT and PDGFRα should be considered standard practice for the treatment of GIST patients. In this article, we will review the common mutations and how they are utilized in clinical management. In addition, we will review the rare D842V PDGFRα mutation and the diverse molecular group that lacks a mutation in either cKIT or PDGFRα (wild-type GIST) which are best treated on clinical trial. Finally, we will look forward at the future …
Promising Therapeutics Of Gastrointestinal Cancers In Clinical Trials, Lingling Du, Zheng Che, Andrea Wang-Gillam
Promising Therapeutics Of Gastrointestinal Cancers In Clinical Trials, Lingling Du, Zheng Che, Andrea Wang-Gillam
Open Access Publications
Many novel therapeutics are being developed for patients with cancers along the gastrointestinal (GI) tract. These emerging agents are frequently classified by their biological targets such as tumor growth pathways, tumor metabolism, microenvironment, etc. Some agents targeting cancer growth pathways are based on existing clinically validated therapeutic targets, such as regorafenib for hepatocellular carcinoma (HCC), while other agents focus on newly identified targets, such as
Molecular Landscape And Sub-Classification Of Gastrointestinal Cancers: A Review Of Literature, Bita Fakhri, Kian-Huat Lim
Molecular Landscape And Sub-Classification Of Gastrointestinal Cancers: A Review Of Literature, Bita Fakhri, Kian-Huat Lim
Open Access Publications
The historical approach of diagnosing cancer types based entirely on anatomic origin and histologic features, and the "one-size-fit-all" therapeutic approach, are inadequate in modern cancer treatment. From decades of research we now know that cancer is a highly heterogeneous disease driven by complex genetic or epigenetic alterations. The advent of various high throughput molecular tools has now enabled us to view and sub-classify each cancer type based on their distinct molecular features, in addition to histologic classification, with the promise of individualized treatment strategies tailored towards each specific subtype to improve patient outcomes. In this review, we have made an …
Current Biologics For Treatment Of Biliary Tract Cancers, Diana Y. Zhao, Kian-Huat Lim
Current Biologics For Treatment Of Biliary Tract Cancers, Diana Y. Zhao, Kian-Huat Lim
Open Access Publications
Biliary tract cancers (BTC) is a group of malignancies that arise from the epithelial cells of the biliary tree. These cancers are typically classified by anatomic site of origin: intrahepatic cholangiocarcinoma (IHCC) and extrahepatic cholangiocarcinoma (EHCC), and gallbladder cancer (GBC). To date, complete surgical resection remains the mainstay of treatment especially for earlier stage disease. Unfortunately, most patients present with advanced or metastatic disease, when systemic chemotherapy is the only treatment option. Due to the paucity of effective treatments, BTCs have a dismal prognosis. There is a tremendous need to better understand the disease biology, discover new therapies, and improve …
Biologic Therapy In Esophageal And Gastric Malignancies: Current Therapies And Future Directions, Pamela Samson, A. Craig Lockhart
Biologic Therapy In Esophageal And Gastric Malignancies: Current Therapies And Future Directions, Pamela Samson, A. Craig Lockhart
Open Access Publications
Biologic agents, including targeted antibodies as well as immunomodulators, are demonstrating unparalleled development and study across the entire spectrum of human malignancy. This review summarizes the current state of biologic therapies for esophageal, esophagogastric, and gastric malignancies, including those that target human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), c-Met, mechanistic target of rapamycin (mTOR) and immunomodulators. We focus primarily on agents that have been included in phase II and III clinical trials in locally advanced, progressive, or metastatic esophageal and gastric malignancies. At this time, only two biologic therapies are …
Gdf15 Is Elevated In Mice Following Retinal Ganglion Cell Death And In Glaucoma Patients, Norimitsu Ban, Carla J. Siegfried, Jonathan B. Lin, Ying-Bo Shui, Julia Sein, Wolfgang Pita-Thomas, Abdoulaye Sene, Andrea Santeford, Mae Gordon, Rachel Lamb, Zhenyu Dong, Shannon C. Kelly, Valeria Cavalli, Jun Yoshino, Rajendra S. Apte
Gdf15 Is Elevated In Mice Following Retinal Ganglion Cell Death And In Glaucoma Patients, Norimitsu Ban, Carla J. Siegfried, Jonathan B. Lin, Ying-Bo Shui, Julia Sein, Wolfgang Pita-Thomas, Abdoulaye Sene, Andrea Santeford, Mae Gordon, Rachel Lamb, Zhenyu Dong, Shannon C. Kelly, Valeria Cavalli, Jun Yoshino, Rajendra S. Apte
Open Access Publications
Glaucoma is the second leading cause of blindness worldwide. Physicians often use surrogate endpoints to monitor the progression of glaucomatous neurodegeneration. These approaches are limited in their ability to quantify disease severity and progression due to inherent subjectivity, unreliability, and limitations of normative databases. Therefore, there is a critical need to identify specific molecular markers that predict or measure glaucomatous neurodegeneration. Here, we demonstrate that growth differentiation factor 15 (GDF15) is associated with retinal ganglion cell death. Gdf15 expression in the retina is specifically increased after acute injury to retinal ganglion cell axons and in a murine chronic glaucoma model. …
Incidental Angiosarcoma Of The Pancreas: A Case Report Of A Rare, Asymptomatic Tumor, Patrick J Worth, Michael Turner, Chet W Hammill
Incidental Angiosarcoma Of The Pancreas: A Case Report Of A Rare, Asymptomatic Tumor, Patrick J Worth, Michael Turner, Chet W Hammill
Open Access Publications
No abstract provided.
Lrrk2 But Not Atg16l1 Is Associated With Paneth Cell Defect In Japanese Crohn's Disease Patients, Ta-Chiang Liu, Takeo Naito, Zhenqiu Liu, Kelli L Vandussen, Talin Haritunians, Dalin Li, Katsuya Endo, Yosuke Kawai, Masao Nagasaki, Yoshitaka Kinouchi, Dermot P. B. Mcgovern, Tooru Shimosegawa, Yoichi Kakuta, Thaddeus S Stappenbeck
Lrrk2 But Not Atg16l1 Is Associated With Paneth Cell Defect In Japanese Crohn's Disease Patients, Ta-Chiang Liu, Takeo Naito, Zhenqiu Liu, Kelli L Vandussen, Talin Haritunians, Dalin Li, Katsuya Endo, Yosuke Kawai, Masao Nagasaki, Yoshitaka Kinouchi, Dermot P. B. Mcgovern, Tooru Shimosegawa, Yoichi Kakuta, Thaddeus S Stappenbeck
Open Access Publications
No abstract provided.
Mapk Signaling Promotes Axonal Degeneration By Speeding The Turnover Of The Axonal Maintenance Factor Nmnat2, Lauren J. Walker, Daniel W. Summers, Yo Sasaki, Ej Brace, Jeffrey Milbrandt, Aaron Diantonio
Mapk Signaling Promotes Axonal Degeneration By Speeding The Turnover Of The Axonal Maintenance Factor Nmnat2, Lauren J. Walker, Daniel W. Summers, Yo Sasaki, Ej Brace, Jeffrey Milbrandt, Aaron Diantonio
Open Access Publications
Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD
Pacs Viewbook 2017-2018, Program In Audiology And Communication Sciences
Pacs Viewbook 2017-2018, Program In Audiology And Communication Sciences
PACS News
No abstract provided.
Aberrantly Activated Cox-2 And Wnt Signaling Interact To Maintain Cancer Stem Cells In Glioblastoma, Megan Wu, Jennifer Guan, Chris Li, Simon Gunter, Labeeba Nusrat, Sheena Ng, Karan Dhand, Cindi Morshead, Albert Kim, Sunit Das
Aberrantly Activated Cox-2 And Wnt Signaling Interact To Maintain Cancer Stem Cells In Glioblastoma, Megan Wu, Jennifer Guan, Chris Li, Simon Gunter, Labeeba Nusrat, Sheena Ng, Karan Dhand, Cindi Morshead, Albert Kim, Sunit Das
Open Access Publications
No abstract provided.
Cell-Free Measurements Of Brightness Of Fluorescently Labeled Antibodies, Haiying Zhou, George Tourkakis, Dennis Shi, David M. Kim, Hairong Zhang, Tommy Du, William C. Eades, Mikhail Y. Berezin
Cell-Free Measurements Of Brightness Of Fluorescently Labeled Antibodies, Haiying Zhou, George Tourkakis, Dennis Shi, David M. Kim, Hairong Zhang, Tommy Du, William C. Eades, Mikhail Y. Berezin
Open Access Publications
No abstract provided.
Targeting Dendritic Cells To Accelerate T-Cell Activation Overcomes A Bottleneck In Tuberculosis Vaccine Efficacy, Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader
Targeting Dendritic Cells To Accelerate T-Cell Activation Overcomes A Bottleneck In Tuberculosis Vaccine Efficacy, Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader
Open Access Publications
No abstract provided.
Cis-Regulatory Circuits Regulating Nek6 Kinase Overexpression In Transformed B Cells Are Super-Enhancer Independent, Yue Huang, Olivia I. Koues, Jiang-Yang Zhao, Regina Liu, Sarah C. Pyfrom, Jacqueline E. Payton, Eugene M. Oltz
Cis-Regulatory Circuits Regulating Nek6 Kinase Overexpression In Transformed B Cells Are Super-Enhancer Independent, Yue Huang, Olivia I. Koues, Jiang-Yang Zhao, Regina Liu, Sarah C. Pyfrom, Jacqueline E. Payton, Eugene M. Oltz
Open Access Publications
No abstract provided.
The Retina Visual Cycle Is Driven By Cis Retinol Oxidation In The Outer Segments Of Cones, Shinya Sato, Rikard Frederiksen, M. Carter Cornwall, Vladimir J. Kefalov
The Retina Visual Cycle Is Driven By Cis Retinol Oxidation In The Outer Segments Of Cones, Shinya Sato, Rikard Frederiksen, M. Carter Cornwall, Vladimir J. Kefalov
Open Access Publications
No abstract provided.
Epidermal Growth Factor Receptors Containing A Single Tyrosine In Their C-Terminal Tail Bind Different Effector Molecules And Are Signaling-Competent, Kamaldeep Gill, Jennifer L. Macdonald-Obermann, Linda J. Pike
Epidermal Growth Factor Receptors Containing A Single Tyrosine In Their C-Terminal Tail Bind Different Effector Molecules And Are Signaling-Competent, Kamaldeep Gill, Jennifer L. Macdonald-Obermann, Linda J. Pike
Open Access Publications
No abstract provided.
Plasma Rest: A Novel Candidate Biomarker Of Alzheimer's Disease Is Modified By Psychological Intervention In An At-Risk Population, N. J. Ashton, A. Hye, C. A. Leckey, A. R. Jones, A. Gardner, C. Elliott, J. L. Wetherell, E. J. Lenze, R. Killick, N. L. Marchant
Plasma Rest: A Novel Candidate Biomarker Of Alzheimer's Disease Is Modified By Psychological Intervention In An At-Risk Population, N. J. Ashton, A. Hye, C. A. Leckey, A. R. Jones, A. Gardner, C. Elliott, J. L. Wetherell, E. J. Lenze, R. Killick, N. L. Marchant
Open Access Publications
No abstract provided.
An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells, Julia Tcw, Minghui Wang, Anna A. Pimenova, Kathryn R. Bowles, Brigham J. Hartley, Emre Lacin, Saima I. Machlovi, Rawan Abdelaal, Celeste M. Karch, Hemali Phatnani, Paul A. Slesinger, Bin Zhang, Alison M. Goate, Kristen J. Brennand
An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells, Julia Tcw, Minghui Wang, Anna A. Pimenova, Kathryn R. Bowles, Brigham J. Hartley, Emre Lacin, Saima I. Machlovi, Rawan Abdelaal, Celeste M. Karch, Hemali Phatnani, Paul A. Slesinger, Bin Zhang, Alison M. Goate, Kristen J. Brennand
Open Access Publications
No abstract provided.
The Cyprinodon Variegatus Genome Reveals Gene Expression Changes Underlying Differences In Skull Morphology Among Closely Related Species, Ezra S. Lencer, Wesley C. Warren, Richard Harrison, Amy R. Mccune
The Cyprinodon Variegatus Genome Reveals Gene Expression Changes Underlying Differences In Skull Morphology Among Closely Related Species, Ezra S. Lencer, Wesley C. Warren, Richard Harrison, Amy R. Mccune
Open Access Publications
No abstract provided.
Fibulin-4 Is Essential For Maintaining Arterial Wall Integrity In Conduit But Not Muscular Arteries, Carmen M. Halabi, Thomas J. Broekelmann, Michelle Lin, Vivian S. Lee, Mon-Li Chu, Robert P. Mecham
Fibulin-4 Is Essential For Maintaining Arterial Wall Integrity In Conduit But Not Muscular Arteries, Carmen M. Halabi, Thomas J. Broekelmann, Michelle Lin, Vivian S. Lee, Mon-Li Chu, Robert P. Mecham
Open Access Publications
No abstract provided.
Two Forms Of Death In Ageing Caenorhabditis Elegans, Yuan Zhao, Ann F. Gilliat, Matthias Ziehm, Mark Turmaine, Hongyuan Wang, Marina Ezcurra, Chenhao Yang, George Phillips, David Mcbay, William B. Zhang, Linda Partridge, Zachary Pincus, David Gems
Two Forms Of Death In Ageing Caenorhabditis Elegans, Yuan Zhao, Ann F. Gilliat, Matthias Ziehm, Mark Turmaine, Hongyuan Wang, Marina Ezcurra, Chenhao Yang, George Phillips, David Mcbay, William B. Zhang, Linda Partridge, Zachary Pincus, David Gems
Open Access Publications
No abstract provided.
Washington University Magazine, Fall/Winter 2017
Washington University Magazine, Fall/Winter 2017
Washington University Magazine
No abstract provided.
Washington University Magazine, Spring 2017
Washington University Magazine, Spring 2017
Washington University Magazine
No abstract provided.
Washington University Magazine, Summer 2017
Washington University Magazine, Summer 2017
Washington University Magazine
No abstract provided.
Moving Forward With Actionable Therapeutic Targets And Opportunities In Endometrial Cancer: Nci Clinical Trials Planning Meeting Report On Identifying Key Genes And Molecular Pathways For Targeted Endometrial Cancer Trials, David G. Mutch, Et Al
Open Access Publications
No abstract provided.