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Articles 14161 - 14190 of 20421
Full-Text Articles in Entire DC Network
Neural Representation Of Temporal Duration: Coherent Findings Obtained With The “Lossy Integration” Model, Olga V. Sysoeva, Marc Wittmann, Jiri Wackermann
Neural Representation Of Temporal Duration: Coherent Findings Obtained With The “Lossy Integration” Model, Olga V. Sysoeva, Marc Wittmann, Jiri Wackermann
Open Access Publications
No abstract provided.
Ethanol Enhances Neurosteroidogenesis In Hippocampal Pyramidal Neurons By Paradoxical Nmda Receptor Activation, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski
Ethanol Enhances Neurosteroidogenesis In Hippocampal Pyramidal Neurons By Paradoxical Nmda Receptor Activation, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski
Open Access Publications
Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons. This neurosteroid staining was increased following 15 min administration of 60 mm but not 20 mm ethanol, and the enhancement was blocked by finasteride and dutasteride, selective inhibitors of 5α-reductase, a key enzyme required for allopregnanolone synthesis. Consistent with a prior report indicating that N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation can promote steroid production, we observed that D-2-amino-5-phosphonovalerate (APV), a competitive NMDAR antagonist, blocked the effects of 60 mm ethanol on staining. We previously reported that …
Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody
Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody
Open Access Publications
Alzheimer's disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury (TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in ∼30% of human subjects after severe TBI. Intra-axonal accumulations of tau but not tangle-like pathologies have also been found in these patients. Whether and how these acute accumulations contribute to subsequent AD development is not …
Exome Sequencing Identifies An Myh3 Mutation In A Family With Distal Arthrogryposis Type 1, David M. Alvarado, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs
Exome Sequencing Identifies An Myh3 Mutation In A Family With Distal Arthrogryposis Type 1, David M. Alvarado, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs
Open Access Publications
No abstract provided.
Role Of Guanylyl Cyclase Modulation In Mouse Cone Phototransduction, Keisuke Sakurai, Jeannie Chen, Vladimir J. Kefalov
Role Of Guanylyl Cyclase Modulation In Mouse Cone Phototransduction, Keisuke Sakurai, Jeannie Chen, Vladimir J. Kefalov
Open Access Publications
A negative phototransduction feedback in rods and cones is critical for the timely termination of their light responses and for extending their function to a wide range of light intensities. The calcium feedback mechanisms that modulate phototransduction in rods have been studied extensively. However, the corresponding modulation mechanisms that enable cones to terminate rapidly their light responses and to adapt in bright light, properties critical for our daytime vision, are still not understood. In cones, calcium feedback to guanylyl cyclase is potentially a key step in phototransduction modulation. The guanylyl cyclase activity is modulated by the calcium-binding guanylyl cyclase activating …
Informatics And Data Mining Tools And Strategies For The Human Connectome Project, Daniel S. Marcus, John Harwell, Timothy Olsen, Michael Hodge, Matthew F. Glasser, Fred Prior, Mark Jenkinson, Timothy Laumann, Sandra W. Curtiss, David C. Van Essen
Informatics And Data Mining Tools And Strategies For The Human Connectome Project, Daniel S. Marcus, John Harwell, Timothy Olsen, Michael Hodge, Matthew F. Glasser, Fred Prior, Mark Jenkinson, Timothy Laumann, Sandra W. Curtiss, David C. Van Essen
Open Access Publications
No abstract provided.
Biomedical And Psychosocial Factors Associated With Disability After Peripheral Nerve Injury, Christine B. Novak, Dimitri J. Anastakis, Dorcas E. Beaton, Susan E. Mackinnon, Joel Katz
Biomedical And Psychosocial Factors Associated With Disability After Peripheral Nerve Injury, Christine B. Novak, Dimitri J. Anastakis, Dorcas E. Beaton, Susan E. Mackinnon, Joel Katz
Open Access Publications
No abstract provided.
Incidence Of Symptomatic Venous Thromboembolism In Oncologic Patients Undergoing Lower-Extremity Endoprosthetic Arthroplasty, Brandon A. Ramo, Anthony M. Griffin, Corey S. Gill, Douglas J. Mcdonald, Jay S. Wunder, Peter Ferguson, Robert S. Bell, Sharon E. Phillips, Herbert S. Schwartz, Ginger E. Holt
Incidence Of Symptomatic Venous Thromboembolism In Oncologic Patients Undergoing Lower-Extremity Endoprosthetic Arthroplasty, Brandon A. Ramo, Anthony M. Griffin, Corey S. Gill, Douglas J. Mcdonald, Jay S. Wunder, Peter Ferguson, Robert S. Bell, Sharon E. Phillips, Herbert S. Schwartz, Ginger E. Holt
Open Access Publications
No abstract provided.
Clinical Presentation Of Symptomatic Acetabular Dysplasia In Skeletally Mature Patients, Ryan M. Nunley, Heidi Prather, Devyani Hunt, Perry L. Schoenecker, John C. Clohisy
Clinical Presentation Of Symptomatic Acetabular Dysplasia In Skeletally Mature Patients, Ryan M. Nunley, Heidi Prather, Devyani Hunt, Perry L. Schoenecker, John C. Clohisy
Open Access Publications
No abstract provided.
Radiographic Structural Abnormalities Associated With Premature, Natural Hip-Joint Failure, John C. Clohisy, Michael A. Dobson, Jason F. Robison, Lucian C. Warth, Jie Zheng, Steve S. Liu, Tameem M. Yehyawi, John J. Callaghan
Radiographic Structural Abnormalities Associated With Premature, Natural Hip-Joint Failure, John C. Clohisy, Michael A. Dobson, Jason F. Robison, Lucian C. Warth, Jie Zheng, Steve S. Liu, Tameem M. Yehyawi, John J. Callaghan
Open Access Publications
No abstract provided.
Dehydroepiandrosterone (Dhea) Replacement Decreases Insulin Resistance And Lowers Inflammatory Cytokines In Aging Humans, Edward P. Weiss, Dennis T. Villareal, Luigi Fontana, Dong-Ho Han, John O. Holloszy
Dehydroepiandrosterone (Dhea) Replacement Decreases Insulin Resistance And Lowers Inflammatory Cytokines In Aging Humans, Edward P. Weiss, Dennis T. Villareal, Luigi Fontana, Dong-Ho Han, John O. Holloszy
Open Access Publications
Plasma dehydroepiandrosterone (DHEA) decreases ~80% between ages 25 and 75 yr. In a preliminary study, we found that 6 mo of DHEA replacement improved insulin action in elderly individuals. The purpose of the present larger, randomized double-blind study was to determine whether a longer period of DHEA replacement improves glucose tolerance. Fifty-seven men and 68 women aged 65 to 75 yr were randomly assigned to 50 mg DHEA or placebo once daily. Year one was a randomized, double blind trial. Year 2 was an open label continuation. DHEA replacement improved glucose tolerance in participants who had abnormal GT initially, reduced …
Managing Stress In The Orthopaedic Family: Avoiding Burnout, Achieving Resilience, M. Catherine Sargent, Wayne Sotile, Mary O. Sotile, Harry Rubash, Peter S. Vezeridis, Larry Harmon, Robert L. Barrack
Managing Stress In The Orthopaedic Family: Avoiding Burnout, Achieving Resilience, M. Catherine Sargent, Wayne Sotile, Mary O. Sotile, Harry Rubash, Peter S. Vezeridis, Larry Harmon, Robert L. Barrack
Open Access Publications
No abstract provided.
Congenital Bone Marrow Failure In Dna-Pkcs Mutant Mice Associated With Deficiencies In Dna Repair, Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen
Congenital Bone Marrow Failure In Dna-Pkcs Mutant Mice Associated With Deficiencies In Dna Repair, Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen
Open Access Publications
No abstract provided.
A Behavioral Analysis Of Spatial Neglect And Its Recovery After Stroke, Jennifer Rengachary, Biyu J. He, Gordon L. Shulman, Maurizio Corbetta
A Behavioral Analysis Of Spatial Neglect And Its Recovery After Stroke, Jennifer Rengachary, Biyu J. He, Gordon L. Shulman, Maurizio Corbetta
Open Access Publications
No abstract provided.
Long-Term Calorie Restriction, But Not Endurance Exercise, Lowers Core Body Temperature In Humans, Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
Long-Term Calorie Restriction, But Not Endurance Exercise, Lowers Core Body Temperature In Humans, Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
Open Access Publications
Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons. However, nothing is known regarding the long-term effects of calorie restriction (CR) with adequate nutrition on body temperature in humans. In this study, 24-hour core body temperature was measured every minute by using ingested telemetric capsules in 24 men and women (mean age 53.7 ± 9.4 yrs) consuming a CR diet for an average of 6 years, 24 age- and sex-matched sedentary (WD) and 24 body fat-matched exercise-trained (EX) volunteers, who were eating Western …
Episodic Memory Retrieval, Parietal Cortex, And The Default Mode Network: Functional And Topographic Analyses, Carlo Sestieri, Maurizio Corbetta, Gian Luca Romani, Gordon L. Shulman
Episodic Memory Retrieval, Parietal Cortex, And The Default Mode Network: Functional And Topographic Analyses, Carlo Sestieri, Maurizio Corbetta, Gian Luca Romani, Gordon L. Shulman
Open Access Publications
The default mode network (DMN) is often considered a functionally homogeneous system that is broadly associated with internally directed cognition (e.g., episodic memory, theory of mind, self-evaluation). However, few studies have examined how this network interacts with other networks during putative "default" processes such as episodic memory retrieval. Using functional magnetic resonance imaging, we investigated the topography and response profile of human parietal regions inside and outside the DMN, independently defined using task-evoked deactivations and resting-state functional connectivity, during episodic memory retrieval. Memory retrieval activated posterior nodes of the DMN, particularly the angular gyrus, but also more anterior and dorsal …
The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction During Drosophila Motor Axon Guidance, Yi-Lan Weng, Nan Liu, Aaron Diantonio, Heather T. Broihier
The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction During Drosophila Motor Axon Guidance, Yi-Lan Weng, Nan Liu, Aaron Diantonio, Heather T. Broihier
Open Access Publications
The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares homology with vertebrate Caskin, a CASK [calcium/calmodulin-(CaM)-activated serine-threonine kinase]-interacting protein. Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related (Lar) receptor protein tyrosine phosphatase. In vivo and in vitro analyses of a panel of ckn loss-of-function alleles indicate that the N-terminal SAM domain of Ckn mediates its interaction with Lar. Like Caskin, Liprin-α is a neuronal adaptor …
Functional Analysis Of Novel Analogues Of E3330 That Block The Redox Signaling Activity Of The Multifunctional Ap Endonuclease/Redox Signaling Enzyme Ape1/Ref-1, Mark R. Kelley, Meihua Luo, April Reed, Dian Su, Sarah Delaplane, Richard F. Borch, Rodney L. Nyland Ii, Michael L. Gross, Millie M. Georgiadis
Functional Analysis Of Novel Analogues Of E3330 That Block The Redox Signaling Activity Of The Multifunctional Ap Endonuclease/Redox Signaling Enzyme Ape1/Ref-1, Mark R. Kelley, Meihua Luo, April Reed, Dian Su, Sarah Delaplane, Richard F. Borch, Rodney L. Nyland Ii, Michael L. Gross, Millie M. Georgiadis
Open Access Publications
No abstract provided.
Myxoid Chondrosarcoma Of The Phalanx With An Ews Translocation: A Case Report And Review Of The Literature, David B. Bumpass, Michael Kyriakos, David A. Rubin, Paul R. Manske, Charles A. Goldfarb
Myxoid Chondrosarcoma Of The Phalanx With An Ews Translocation: A Case Report And Review Of The Literature, David B. Bumpass, Michael Kyriakos, David A. Rubin, Paul R. Manske, Charles A. Goldfarb
Open Access Publications
No abstract provided.