Digital Commons Network^™

Healthcare Utilization And Costs Among High-Need And Frail Mexican American Medicare Beneficiaries, Maricruz Rivera-Hernandez, Amit Kumar, Lin-Na Chou, Tamra Keeney, Nasim Ferdows, Amol Karmarkar, Kyriakos S. Markides, Kenneth Ottenbacher

Physical Medicine and Rehabilitation Publications

Objectives
To examine Medicare health care spending and health services utilization among high-need population segments in older Mexican Americans, and to examine the association of frailty on health care spending and utilization.

Methods
Retrospective cohort study of the innovative linkage of Medicare data with the Hispanic Established Populations for the Epidemiologic Study of the Elderly (H-EPESE) were used. There were 863 participants, which contributed 1,629 person years of information. Frailty, cognition, and social risk factors were identified from the H-EPESE, and chronic conditions were identified from the Medicare file. The Cost and Use file was used to calculate four categories …

Perspectives On Primary Blast Injury Of The Brain: Translational Insights Into Non-Inertial Low-Intensity Blast Injury, Heather R. Siedhoff, Shanyan Chen, Hailong Song, Jiankun Cui, Ibolja Cernak, David X. Cifu, Ralph G. Depalma, Zezong Gu

Physical Medicine and Rehabilitation Publications

Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild” and frequently caused by non-impact blast exposures. Experimental models were developed to reproduce the biological consequences of high-intensity blasts causing moderate to severe brain injuries. However, the pathophysiological mechanisms of low-intensity blast (LIB)-induced neurological deficits have been understudied. This review provides perspectives on primary blast-induced mild TBI models and discusses translational aspects of LIB exposures as defined by standardized physical parameters including overpressure, impulse, and shock wave velocity. Our mouse LIB-exposure model, which reproduces deployment-related scenarios of open-field blast (OFB), caused neurobehavioral changes, including reduced exploratory activities, …

To Vax Or Not To Vax: Predictors Of Anti-Vax Attitudes And Covid-19 Vaccine Hesitancy Prior To Widespread Vaccine Availability, Hannah A. Roberts, D. Angus Clark, Claire Kalina, Carter Sherman, Sarah Brislin, Mary M. Heitzeg, Brian M. Hick

Psychology Publications

The novel coronavirus (COVID-19) is a highly contagious disease responsible for millions of deaths worldwide. Effective vaccines against COVID-19 are now available, however, an extreme form of vaccine hesitancy known as anti-vax attitudes challenge vaccine acceptance and distribution efforts. To understand these anti-vax attitudes and their associated psychological characteristics, we examined several predictors of vaccine hesitancy for COVID-19 and anti-vax attitudes generally. We surveyed 1004 adults (M = 47.0 years, SD = 17.1 years, range 18–98 years) in September-October 2020 across the United States (51% female, 49% male; 76.5% White, 23.5% non-White), prior to widespread availability of the COVID-19 vaccines. …

Impact Of Telelactation Services On Breastfeeding Outcomes Among Black And Latinx Parents: Protocol For The Tele-Milc Randomized Controlled Trial, Lori Uscher-Pines, Jill Demirci, Molly Waymouth, Rebecca Lawrence, Amanda Parks, Ateev Mehrotra, Kristin Ray, Maria Deyoreo, Kandice Kapinos

Psychology Publications

Background: Breastfeeding offers many medical and neurodevelopmental advantages for birthing parents and infants; however, the majority of parents stop breastfeeding before it is recommended. Professional lactation support by the International Board Certified Lactation Consultants (IBCLCs) increases breastfeeding rates; however, many communities lack access to IBCLCs. Black and Latinx parents have lower breastfeeding rates, and limited access to professional lactation support may contribute to this disparity. Virtual “telelactation” consults that use twoway video have the potential to increase access to IBCLCs among disadvantaged populations. We present a protocol for the digital Tele-MILC trial, which uses mixed methods to evaluate the …

Generation Of Nanomaterials By Reactive Laser Synthesis In Liquid, Laysa M. Frias Batista, Ashish B. Nag, Victoria K. Meader, Katharine M. Tibbetts

Chemistry Publications

Nanomaterials with tailored structures and surface chemistry are in high demand, as these materials play increasingly important roles in biology, catalysis, energy storage, and manu- facturing. Their heightened demand has attracted attention towards the development of syn- thesis routes, particularly, laser-synthesis techniques. These efforts drove the refinement of laser ablation in liquid (LAL) and related methods over the past two decades, and have led to the emergence of reactive laser-synthesis techniques that exploit these methods’ character- istic, non-equilibrium conditions. Reactive laser-synthesis approaches foster unique chemical reactions that enable the formation of composite products like multimetallic nanoparticles, supported nanostructures, and complex …

Managing Hypertension, Diabetes, And Cardiovascular Disease Risk Via Short-Term Medical Trips: A Retrospective Longitudinal Study In Santo Domingo, Rose Baumann, Reuben P. Retnam, Carlos M. Hernandez, Victoria Edwards, Mark Ryan

Biostatistics Publications

Background: Short-term medical trips (STMTs) from high-resource countries frequently provide care in low and middle-income countries. Little existing literature objectively tracks the long-term outcomes of these interventions on the receiving populations over time to assess potential benefits and to ensure no harm is being done.

Objectives: The purpose of this study was to objectively analyze the outcomes of a biannual STMT to Santo Domingo, Dominican Republic on hypertension (HTN), diabetes mellitus type 2 (DM2), and cardiovascular disease (CVD) risk over a five-year period (2015-2019).

Methods: Data from 1655 patients was extracted from the electronic medical record. In …

Long-Read Sequencing Of The Zebrafish Genome Reorganizes Genomic Architecture, Yelena Chernyavskaya, Xiaofei Zhang, Jinze Liu, Jessica Blackburn

Biostatistics Publications

Background

Nanopore sequencing technology has revolutionized the field of genome biology with its ability to generate extra-long reads that can resolve regions of the genome that were previously inaccessible to short-read sequencing platforms. Over 50% of the zebrafish genome consists of difficult to map, highly repetitive, low complexity elements that pose inherent problems for short-read sequencers and assemblers.

Results

We used long-read nanopore sequencing to generate a de novo assembly of the zebrafish genome and compared our assembly to the current reference genome, GRCz11. The new assembly identified 1697 novel insertions and deletions over one kilobase in length and placed …

Social Cognitive Outcomes Are Associated With Improvements In Mobility Performance Following Lifestyle Intervention In Prostate Cancer Patients Undergoing Androgen Deprivation Therapy, Zachary L. Chaplow, Alexander R. Lucas, Elizabeth Grainger, Christina Simpson, Ciaran M. Fairman, Victoria R. Descenza, Jessica Bowman, Steven K. Clinton, Brian C. Focht

Health Policy Publications

Objective
To compare the effects of an exercise and dietary intervention with those of standard-of-care management upon change in lift and carry performance and mobility-related self-efficacy beliefs and explore associations in prostate cancer patients undergoing androgen deprivation therapy.

Methods
32 prostate cancer patients (M age = 66.2 years; SD = 7.8) undergoing androgen deprivation therapy were randomly assigned to a 3-month exercise and dietary lifestyle intervention (n = 16) or standard-of-care management (n = 16). Outcome assessments were obtained at baseline, 2- and 3-month follow-up.

Results
The lifestyle intervention resulted in significantly greater improvements in lift and …

Protective Factors Against Alcohol Use In High-Risk College Students, Delani F. Warner, Karen G. Chartier Phd, Msw, The Spit For Science Working Group

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

The Role Of The Nlrp3 Inflammasome In Alzheimer's Disease, Ethan Terman

IRBEH/Spit for Science Publications and Presentations

This study examines the consequences of Alzheimer’s in rat and mice test subjects. The goal is to identify the effects of certain NLRP3 inhibiting drugs and to see if there are any noticeable effects in regards to impeding the pathological development of Alzheimer’s disease. The results are visualized by implementing the immunohistochemical process to identify neurodegeneration in the brain and to assess the expression levels of amyloid beta as an indicator of Alzheimer’s pathology. Other tests are also conducted on these transgenic mice to gauge cognitive functioning levels during the onset of their disease, those being behavior tests, but not …

T1 (Spring 2019) Ethnic-Racial Identity Affirmation Predicting T2 (Spring 2020) Romantic Partner/Friend Relationship Changes Predicting T3 (Fall 2021) Alcohol Use And Anxiety Symptoms Among Latinx Emerging Adults, Vanessa Olazabal, Mehak Ahmed, April Koontz, Arlenis Santana, Chelsea Williams Phd, The Spit For Science Working Group, Danielle Dick Phd

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

An Exploration Of The Use Of Science Specialists And Elementary Students’ Science Achievement, Wesley Roach, Jillian L. Wendt

Journal of Mathematics and Science: Collaborative Explorations

The purpose of this causal-comparative study was to examine the effect of using science specialists in elementary schools on science achievement scores. The sample population consisted of 282 fifth grade students enrolled in Georgia public schools. The data for this study was collected from four public elementary schools’ end-of-year state assessments and analyzed as archival data. An analysis of covariance (ANCOVA) was used to determine if there was a difference between science achievement scores in elementary schools that use science specialists compared to those that do not. Results indicate that no statistically significant difference exists between the science achievement scores …

A Highly Conductive, Flexible, And 3d-Printable Carbon Nanotube-Elastomer Ink For Additive Bio-Manufacturing, Andy Shar, Phillip Glass, Daeha Joung Ph.D.

UROP Posters

The synthesis of a highly conductive, flexible, 3D-printable, and biocompatible ink has been of great interest in the field of bio-based additive manufacturing. Various applications include ultra-sensitive, microscale tactile sensors, patient-customizable scaffolds for cardiac and nerve tissue regeneration, and flexible electrocardiogram (ECG) electrodes. Here, a novel elastomeric carbon nanocomposite is presented consisting of amino-functionalized carbon nanotubes (CNT-NH₂) homogenously dispersed in a one-part room-temperature vulcanizing (RTV) silicone matrix. The use of acetone as a swelling solvent aids in electrical percolation through the elastomer matrix. CNT-NH₂ ratios can be tuned to fit various needs; higher tensile strength is favored …

Review Of The Effects Of Asphalt Fume Emission (Vocs And Pahs) In Vitro, In Vivo And Human Studies, Omran Taqi, Nastassja Lewinski, Elham Fini, Eran Rozewski, Judith Klein-Seetharaman

UROP Posters

Review of the effects of Asphalt fume emission (VOCs and PAHs) in vitro, in vivo and human studies

Omran Taqi, Nastassja Lewinski¹

1) Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA

Background

Asphalt is abundantly available around human operations including road paving and roofing sites. However, their emissions and fumes (specifically volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs)) have been found to have adverse effects on health. Asphalt fumes are a class 2A carcinogen and exposure can increase the risk of lung cancer, asthma, headache, fatigue, and other cardiovascular diseases.

Methods

We used …

A Participatory Group Process To Collect And Disseminate Covid-19 Needs Assessment Data, Areebah Ahmed

UROP Posters

The Richmond, VA COVID-19 Needs Assessment Survey (RVA CoNA) was created in March 2020 to identify behaviors and needs related to COVID-19 in Richmond area adults ages 18 and over. Results are being used to inform support, strategic efforts, and educational outreach of local community organizations. The purpose of this study is to (1) summarize the process used to develop the RVA CoNA, (2) summarize preliminary survey results from a second phase of data collection as well as initial feedback from community partners, and (3) summarize initial conclusions and results dissemination strategies.Community partners and researchers at Virginia Commonwealth University jointly …

Modified Ysk12-Mend-Sirna In Dendritic Cells For Cancer Immunotherapy, Syed S. Alam

UROP Posters

Tumors may induce tolerogenesis through signaling dendritic cells to produce tolerogenic molecules, such as indoleamine 2, 3-dioxygenase 1 (IDO1). Tumor-associated immunosuppression is associated with higher mortality in patients. Small interfering RNA (siRNA) has been shown to silence specific target genes in the target cell. The siRNA associated with these genes could support a gene knockdown of these immunosuppressors and reduce mortality. Delivery of these therapeutic nucleic acids is difficult in vivo because siRNA is easily broken down inside the cell and the bloodstream through present nucleases. Use of liposome polymers has been reviewed extensively in literature. YSK12-C4, a lipid nanoparticle …

Approximating Bayesian Optimal Sequential Designs Using Gaussian Process Models Indexed On Belief States, Joseph Burris

Theses and Dissertations

Fully sequential optimal Bayesian experimentation can offer greater utility than both traditional Bayesian designs and greedy sequential methods, but practically cannot be solved due to numerical complexity and continuous outcome spaces. Approximate solutions can be found via approximate dynamic programming, but rely on surrogate models of the expected utility at each trial of the experiment with hand-chosen features or use methods which ignore the underlying geometry of the space of probability distributions. We propose the use of Gaussian process models indexed on the belief states visited in experimentation to provide utility-agnostic surrogate models for approximating Bayesian optimal sequential designs which …

Labor Union Affiliation And Its Influence On Psychological Well-Being And Depression, Waleed Y. Sami

Theses and Dissertations

The purpose of this quantitative study was to examine the influence labor union affiliation has on psychological well-being and depression. Poverty and income-inequality are large challenges within contemporary American society. Labor unions have historically mitigated income-inequality, promoted solidarity, and decent working conditions. There is growing research on their role as a social determinant of health and mental health. This present study sought to expand this nascent literature base and examine if labor union affiliation influenced psychological well-being (made up of six subscales) and a depression scale through a secondary cross-sectional data analysis, derived from the Wisconsin Longitudinal Study (WLS). A …

Universal Design In Bci: Deep Learning Approaches For Adaptive Speech Brain-Computer Interfaces, Srdjan Lesaja

Theses and Dissertations

In the last two decades, there have been many breakthrough advancements in non-invasive and invasive brain-computer interface (BCI) systems. However, the majority of BCI model designs still follow a paradigm whereby neural signals are preprocessed and task-related features extracted using static, and generally customized, data-independent designs. Such BCI designs commonly optimize narrow task performance over generalizability, adaptability, and robustness, which is not well suited to meeting individual user needs. If one day BCIs are to be capable of decoding our higher-order cognitive commands and conceptual maps, their designs will need to be adaptive architectures that will evolve and grow in …

Development Of Novel, Miniaturized Sperm Cell Isolation Techniques For Sexual Assault Samples, Brittany Celeste Hudson

Theses and Dissertations

The ever-increasing sexual assault evidence collection kit backlog within the United States has prompted the search (and desperate need) for a more efficient, cost-effective, and rapid processing technique that can separate male and female contributions from evidentiary samples. Although backlogs have largely been tackled across the United States and many technological advancements have made the forensic DNA analysis workflow quicker, techniques for handling sexual assault samples remain time-consuming, tedious, and inefficient at separating cellular fractions from the victim and perpetrator. Thus, this research sought to identify a reproducible sperm isolation method using antibodies and/or alternative differential cell lysis techniques as …

Amendment: Literary And Art Journal (2022 Fall)

Amendment, 2004-

Amendment is a VCU student-produced progressive literature and art journal that provides a platform for students to promote equality, tolerance, and social progression through artistic expression.

Transmute, John Ramsey

Mighty Pen Project Anthology & Archive

A soldier returning from Iraq has trouble adjusting back to civilian life.

Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.

Full Issue

Journal of Mathematics and Science: Collaborative Explorations

No abstract provided.

An Examination Of Factors That Support Sustainable Cultural And Curricular Change In Stem Teaching And Learning, Erica Slate Young, Peaches Hash, Sarah Schott, Jack Bookman

Journal of Mathematics and Science: Collaborative Explorations

Using a mixed-methods design, this body of work from the SUMMIT-P consortium explores possible effective conditions for the sustainable reform of STEM teaching and learning at the collegiate level. A model of catalysts for successful and sustainable change is proposed, based on five years of data collection and observations. These catalysts include institutional support, intrinsic and extrinsic motivation of faculty involved, measures of student success, institution size, prior faculty experience, faculty buy-in, and institutional culture. The discussion ends with a delve into the potential broader impacts of this work. For example, this model may help institutions better understand how to …

A Tale Of Four Departments: Interdisciplinary Faculty Learning Communities Informing Mathematics Education, Bryan D. Poole, Caroline Maher-Boulis, John Hearn, Jason Robinson, Patricia Mcclung, Amanda Jones

Journal of Mathematics and Science: Collaborative Explorations

As a result of the Curriculum Foundations Project and the SUMMIT-P consortium, faculty from four different departments at Lee University created a Faculty Learning Community (FLC) with the goal of improving students’ attitudes toward undergraduate mathematics courses, including students’ perception of the utility of mathematics in their lives and the feelings of anxiety that they experience in these courses. The interdisciplinary collaborations resulted in introducing novel activities and manipulatives in various mathematics courses (Introduction to Statistics, Concepts of Mathematics I and II, and Algebra for Calculus). This paper first describes the efforts of creating the inter-departmental FLC. Second, it discusses …

Using An Interdisciplinary Case Study To Incorporate Quantitative Reasoning In Social Work, Nursing, And Mathematics, Elizabeth Post, Mischelle Stone, Lauren Cavner Williams, Mary Beaudry

Journal of Mathematics and Science: Collaborative Explorations

Through the national consortium, SUMMIT-P, Ferris State University faculty collaborated to develop and scaffold mathematics and quantitative reasoning across disciplines to reduce math anxiety. Participants in this collaborative group included faculty from social work, nursing, and mathematics who developed a case study on a Hurricane Katrina scenario that necessitated calculating the need for emergency shelter, water, food, and medicine, and as a response to the potential for a Malaria outbreak. This particular case study allowed faculty to use the lens of social justice to teach mathematical concepts and provided an avenue for nursing and social work students to engage in …

Just In Time Mathematics Review For Accounting Students, Anneke Bart, Michael May S.J., Debbie Pike

Journal of Mathematics and Science: Collaborative Explorations

This paper describes the Just-in-Time Review developed for an undergraduate accounting course. The review materials cover five topics in algebra. Students take an online assessment, and online materials are made available to help students catch up in those areas where some review is recommended. This paper is a case study of the development and implementation of the Just-in-Time Review for an accounting course at Saint Louis University.

Interdisciplinary Collaboration To Develop Meaningful Mathematical Experiences, Susan Ganter, Bill Haver

Journal of Mathematics and Science: Collaborative Explorations

This issue of the Journal of Mathematics and Science: Collaborative Explorations (JMSCE) is the second special volume highlighting the impact of the consortium for Synergistic Undergraduate Mathematics via Multi-institutional Interdisciplinary Teaching Partnerships (SUMMIT-P). The development and goals of SUMMIT-P were outlined in the preface of the first special issue of JMSCE devoted to this project (Ganter & Haver, 2020). Full participation from partner discipline faculty is key to the success of redeveloping introductory mathematics courses in a way that incorporates the contextual needs of the other disciplines. As such, SUMMIT-P’s first task was to find ways to best engage colleagues …

Statistics For Nursing And Allied Health At Saint Louis University In The Spirit Of Summit-P, Kimberly S. Druschel, Mike May, Elizabeth Gockel Blessing

Journal of Mathematics and Science: Collaborative Explorations

This paper describes the renewal of a consumer-based elementary statistics course to benefit students in the nursing and allied health disciplines. While the goal of the course transformation was initially to update the pedagogy of the course and ensure students are able to make connections between the course material and their majors, that goal expanded to include the needs and objectives of the client disciplines. This expanded goal was accomplished by incorporating insights gained from a SUMMIT-P business school collaboration and was based on the Curriculum Foundations project recommendations. The paper addresses course projects, instructor development, faculty roles, and interactions …

Improving Student Knowledge Transfer Between Mathematics And Engineering Courses Through Structured Cross-Disciplinary Collaboration: A Summit-P Initiative, Laura Ellwein Fix, Afroditi Filippas, Maila Brucal-Hallare, Rebecca Segal

Journal of Mathematics and Science: Collaborative Explorations

Student learning across STEM disciplines has been shown to increase with greater integration of applications in mathematics courses. One challenge of this effort is that identical constructs are often presented differently in the partner disciplines than in the mathematics courses. This leads to student confusion and an inability to transfer critical knowledge in their disciplinary courses, even for students who have mastered the mathematical paradigms. An interdisciplinary team at VCU consisting of mathematics and engineering faculty has worked to improve the knowledge transfer required for the integration of applications in the Differential Equations curriculum. This work is part of the …