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Full-Text Articles in Entire DC Network
Exploring Substance Use Disorders Community Outpatient Counselors’ Experiences Treating Clients With Co-Occurring Medical Conditions: An Interpretative Phenomenological Analysis, Lauretta Cathers
Theses and Dissertations
Abstract EXPLORING SUBSTANCE USE DISORDERS COMMUNITY OUTPATIENT COUNSELORS’ EXPERIENCES TREATING CLIENTS WITH CO-OCCURRING MEDICAL CONDITIONS. AN INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS Lauretta Anne Cathers, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2013 Major Director: Amy Armstrong, PhD, Chair, Rehabilitation Counseling The Interpretative Phenomenological Analysis study presents the findings from a qualitative study examining substance use disorders (SUD) community outpatient treatment counselors’ experiences treating clients with co-occurring medical conditions. Interviews from five SUD community outpatient treatment counselors resulted in four emerging super-ordinate themes. The findings illustrate …
[2013-09-13] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors
[2013-09-13] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
The Role Of Outer Membrane Protein A In Anaplasma Marginale Cellular Invasion And Its Potential As A Cross-Protective Antigen, Sarvani Emani
The Role Of Outer Membrane Protein A In Anaplasma Marginale Cellular Invasion And Its Potential As A Cross-Protective Antigen, Sarvani Emani
Theses and Dissertations
Anaplasma phagocytophilum and A. marginale are the etiologic agents of human granulocytic anaplasmosis and bovine anaplasmosis, respectively. Both diseases can be severe, even fatal, and protective vaccines for each are lacking. We recently identified A. phagocytophilum outer membrane protein A (ApOmpA) as being critical for cellular invasion and is expressed during infection of mammalian but not tick cells. Disrupting ApOmpA-host cell interactions significantly inhibits A. phagocytophilum entry into host cells. ApOmpA and its A. marginale ortholog, AM854 (A. marginale OmpA; AmOmpA) exhibit 44% amino acid identity. The ApOmpA invasin domain is highly conserved between both proteins. In this study, we …
Ink (2013-09)
Ink, 2008-
The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.
The Design And Development Of A Perceptual-Based Haptic Display Device, Sohaib Akhter
The Design And Development Of A Perceptual-Based Haptic Display Device, Sohaib Akhter
Theses and Dissertations
Graphical information presented as pictures, graphs, maps, and the like are an important media for relaying knowledge and are a fundamental means of education rarely experienced by people who are blind or have a severe visual impairment. This thesis presents the design, development and testing of a multiple finger, haptic matrix dynamic display device capable of relaying graphical information through simulated textures. The design is based on user perception studies that determined which hand constraints provided the best tradeoff between simplicity of design, accuracy and time to answer. The best design was one that incorporated multiple fingers in close proximity …
Smart Superhydrophobic Materials, Adetoun Taiwo
Smart Superhydrophobic Materials, Adetoun Taiwo
Theses and Dissertations
Superhydrophobicity refers to surfaces with extremely large water droplet contact angles (usually greater than 150°). This phenomenon requires a hydrophobic material with micro or nano-scale roughness. Superhydrophobic surfaces exist in nature (e.g. the lotus leaf) and can be produced synthetically. This project focuses on the development and characterization of superhydrophobic materials with tunable wettability (i.e. smart superhydrophobic materials). In this study, surfaces were prepared by electrospinning thin, aligned polystyrene fibers onto a piezoelectric unimorph substrate. Results showed electric field induced changes in substrate curvature, which produced corresponding changes in surface wettability. From experiments, an average change in water contact angle …
The Fundamental Law Of Hungary And Its Effect On Social Cohesion, Veronica Peterkin
The Fundamental Law Of Hungary And Its Effect On Social Cohesion, Veronica Peterkin
UROP Posters
During the Hungarian Revolution of 1956, citizens of Hungary stood side by side to revolt against Communism. Today, the Fidesz party, a right wing group that considers itself more moderate than the infamous Jobbik party, has a majority in Parliament as well as the presidency and recently proposed a new constitution that took act on January 1, 2012. Through analysis of survey studies and interviews conducted by researchers with citizens and scholars, I determined that social trust has decreased and the presence of racism has increased in Hungary during the past three years. Although the idea of passing the new …
A Novel Biorelevant In Vitro System To Predict The In Vivo Performance Of Oral Transmucosal Products, Poonam Delvadia
A Novel Biorelevant In Vitro System To Predict The In Vivo Performance Of Oral Transmucosal Products, Poonam Delvadia
Theses and Dissertations
In vitro dissolution, release and permeation testing is a common practice during drug product research and development. These in vitro tests, if predictive, are referred to as biorelevant tests and can play diverse roles to facilitate and expedite product development in a cost effective manner. Oral transmucosal products (OTPs) are currently tested using compendial and modified in vitro tests which may or may not be good predictors of in vivo performance due to a lack of biorelevance. A critical need for a broadly applicable and biorelevant in vitro system for OTPs has been expressed in the literature and the goal …
Anti-Cytomegalovirus Activity Of Atanyl Blue Prl, An Anthraquinone Derivative, Zohaib Alam
Anti-Cytomegalovirus Activity Of Atanyl Blue Prl, An Anthraquinone Derivative, Zohaib Alam
Theses and Dissertations
Cytomegalovirus (CMV) is a significant cause of mortality and morbidity in immunocompromised patients and an important cause of birth defects if acquired in utero. The licensed CMV antivirals, ganciclovir, cidofovir and foscarnet, all target the viral DNA polymerase. For each drug prolonged use is associated with significant toxicities and development of drug resistance. None are approved for use during pregnancy. Therefore, development of new anti-CMV drugs that target different pathways would be beneficial. All herpesviruses encode an alkaline nuclease. That genetic disruption of the CMV alkaline nuclease, UL98, reduces CMV replication by 1,000-fold suggests that UL98 may be a useful …
Semi-Interpenetrating Network Gelatin Fiber Sca Old For Oral Mucosal Delivery Of Insulin, Leyuan Xu
Semi-Interpenetrating Network Gelatin Fiber Sca Old For Oral Mucosal Delivery Of Insulin, Leyuan Xu
Theses and Dissertations
Common therapy for diabetes mellitus is subcutaneous administration of insulin that is subject to serious disadvantages, such as patient noncompliance and occasional hypoglycemia. Hence, oral administration of insulin could be more convenient and serve as a desired route. However, oral administration of insulin is severely limited by the low bioavailability of insulin through the gastrointestinal tract. In this study, a semi-interpenetrating network gelatin fiber scaffold (sIPN GF) was fabricated for oral mucosal delivery of insulin as an alternative route. This sIPN GF was engineered from an electrospun gelatin fiber scaffold (GF), which was further crosslinked with polyethylene glycol diacrylate (PEG-DA) …
Spatial And Temporal Estimation Of Nanomechanical Properties Via Atomic Force Microscopy, Eric Mccullough
Spatial And Temporal Estimation Of Nanomechanical Properties Via Atomic Force Microscopy, Eric Mccullough
Theses and Dissertations
Engineering the next generation of smart materials will require new methods of surface characterization, analysis and identification that can be performed not only in three dimensional space but also in the temporal dimension. Of particular interest is the understanding of mechanical properties of complex systems at the micro and nanoscales. Current techniques for such measurements are hampered by challenges including their inability to probe systems in complex microenvironments, non-destructively, or at nanometer resolution. This thesis outlines work in the development of techniques to study diverse systems and determine their mechanical properties using the Atomic Force Microscope as the primary tool. …
Negative Perception Of Sexuality In Advertising And The Counterarguments Or Solutions To These Reactions, Rachael Mott
Negative Perception Of Sexuality In Advertising And The Counterarguments Or Solutions To These Reactions, Rachael Mott
UROP Posters
This paper focuses on the comparison of how people in the United States perceive sexuality in advertising and how negative reactions may be prevented or counteracted. Through the analyzing of multiple articles on the perception of sexuality, data was analyzed to find that in most situations, the use of sexuality in advertising negatively affects the sale of a product. This is because of a reduction of brand recall and the fact that many consumers, mainly women, find overt sexuality in a public advertisement offensive; however all of these negative effects can either be prevented or offset. If the product at …
Examining The Csi Effect And The Influence Of Forensic Crime Television On Future Jurors, Christopher Kopacki
Examining The Csi Effect And The Influence Of Forensic Crime Television On Future Jurors, Christopher Kopacki
Theses and Dissertations
This dissertation examines the relationship exposure to forensic crime television has on a potential juror’s willingness to find a suspect guilty when presented with a case involving only circumstantial and eyewitness evidence. This study also looks at a potential juror’s expectation of forensic evidence being presented at trial based upon this exposure. To better understand these relationships, the study utilized social constructionism as the theoretical framework. To collect data, an original survey instrument that included either a violent or non-violent crime scenario was developed. Reponses from 1572 undergraduate students were analyzed to better understand what might influence their willingness to …
Role Of Crc In The Regulation Of Alginate In Pseudomonas Aeruginosa, Arfeen Alam
Role Of Crc In The Regulation Of Alginate In Pseudomonas Aeruginosa, Arfeen Alam
Theses and Dissertations
As Pseudomonas aeruginosa adapts to the Cystic Fibrosis (CF) and chronic obstructive pulmonary disease (COPD) lung environments, mucoid strains often appear as a result of alginate overproduction. Such mucoid conversion is associated with the establishment of a chronic pulmonary infection. Alginate confers resistance to phagocytosis and has other pathogenic properties. The regulation of alginate production is complex and involves an alternate sigma factor, anti-sigmas and several DNA-binding transcriptional regulators. Here we examined the possibility that the catabolic repression control (Crc) protein repressor may affect alginate gene expression. A putative Crc binding site was observed adjacent to the ribosome binding site …
Exploring Electric Field-Induced Changes In Astrocyte Behavior, Doel Dhar
Exploring Electric Field-Induced Changes In Astrocyte Behavior, Doel Dhar
Theses and Dissertations
Electric fields, which are generated by the movement of charged ions across membranes, are found in all biological systems and can influence cellular components ranging from amino acids to biological macromolecules. Physiological field strengths range from 1 – 200 mV/mm, and these electric fields are especially elevated at sites of cellular growth during development and regeneration. It has previously been demonstrated that elevated electric fields induce alignment of astrocyte processes in vitro, enhancing the rate of neurite outgrowth. It is believed that electric fields of varying physiological strength affect other astrocytic responses associated with regeneration. To characterize the duration over …
From Cooking Meals To Cocking Guns, Janeal Downs
From Cooking Meals To Cocking Guns, Janeal Downs
UROP Posters
Empowerment through Violence: Most people associate gangs with their ability to destroy communities by engaging in drug use, drug distribution and violence, and they have been studied for decades. Researchers are interested in defining gangs, understanding how they work, and finding reasons why the members join and stay in the gangs. However, when researchers study gangs, they invariably focus on male members. When and if these studies mention women, most of the research solely references their roles as sexual objects or girlfriends of gang members. Only recently have a small percentage of researchers begun to include females as a part …
Characterization Of Cyclic Di-Gmp Binding By The Sole Borrelia Burgdorferi And Borrelia Hermsii Pilz Domain-Containing Proteins, Katherine Louise Mallory
Characterization Of Cyclic Di-Gmp Binding By The Sole Borrelia Burgdorferi And Borrelia Hermsii Pilz Domain-Containing Proteins, Katherine Louise Mallory
Theses and Dissertations
Borrelia burgdorferi and Borrelia hermsii cause Lyme disease and relapsing fever, respectively. These spirochetes are maintained in an enzootic cycle, involving tick vectors and mammalian hosts. Differential gene expression is central in their survival in various environmental conditions. C-di-GMP has been demonstrated to be important in bacterial adaptation. Borrelia deletion mutant phenotypes have shown that c-di-GMP regulates motility, infectivity, and enzootic cycle progression. As the only known receptors encoded by Borrelia, PlzA and PlzC characterization is necessary in delineating c-di-GMP roles within the cell. In this study, biochemical, biophysical, and FRET methods demonstrated that these proteins exhibit a structural rearrangement …
Fabrication Of Surface Amine Gradients By Controlled-Rate Infusion For Chromatographic Applications, Balamurali Kannan
Fabrication Of Surface Amine Gradients By Controlled-Rate Infusion For Chromatographic Applications, Balamurali Kannan
Theses and Dissertations
Surface gradients are materials that exhibit a variation in properties such as chemical composition, topography etc., in a continuous and/or discrete fashion. They are broadly classified as chemical and physical gradients depending upon the properties that gradient exhibits. Among those, chemical gradients on various surfaces have been a great interest in materials research for the last two decades. This is due to the applications of gradients in various fields such as biological sciences, separation science, etc. There have been several different approaches developed for the preparation of chemical gradients. Silane-based approaches are among those that are widely used because of …
Ex Vivo Reprogramming Of Tumor-Reactive Immune Cells From Fvbn202 Mice Bearing Lung Metastatic Mammary Carcinoma: An Immunotherapeutic Opportunity Revealed Against Recurrence, Charles Hall
Theses and Dissertations
Metastatic breast cancer treatment has seen few advances in recent years, yet treatment resistance continues to rise, causing disease recurrence. A pilot study was performed to determine the efficacy of ex vivo expansion and reprogramming of tumor-reactive immune cells from experimental metastatic tumor-sensitized mice. Also, phenotypic changes in tumors due to metastasis or tumor microenvironment influences were characterized. Metastatic neu+ mouse mammary carcinoma (mMMC) and its distant relapsing neu-antigen-negative variant (mANV) were investigated in FVBN202 mice. Tumor-reactive central memory CD8+ T cells and activated NK/NKT cells were successfully reprogrammed and expanded during 6-day expansion from mMMC- and/or mANV-sensitized mice, resulting …
Role Of Tyk2 In Regulating Energy Expenditure And Preventing Obesity, Vidisha Raje
Role Of Tyk2 In Regulating Energy Expenditure And Preventing Obesity, Vidisha Raje
Theses and Dissertations
Obesity develops when energy intake exceeds energy expenditure. Defect in the function of brown fat and skeletal muscle, two of the major tissues that contribute towards energy expenditure, lead to the development of obesity and metabolic syndrome. Our previous findings suggest that Tyk2 deficient mice become obese and develop the metabolic syndrome. Tyk2, which is a tyrosine kinase of the JAK-STAT signaling family, is important for optimal brown development and function. Since brown fat and skeletal muscle, both are derived from the Myf5+ lineage of mesenchymal stem cells, we also characterized the role of Tyk2 in the development and function …
Identification And Characterization Of Ethanol Responsive Genes In Acute Ethanol Behaviors In Caenorhabditis Elegans, Joseph Alaimo
Identification And Characterization Of Ethanol Responsive Genes In Acute Ethanol Behaviors In Caenorhabditis Elegans, Joseph Alaimo
Theses and Dissertations
Alcohol abuse and dependence are complex disorders that are influenced by many genetic and environmental factors. Acute behavioral responses to ethanol have predictive value for determining an individual’s long-term susceptibility to alcohol abuse and dependence. These behavioral responses are strongly influenced by genetics. Here, we have explored the role of genetic influences on acute behavioral responses to ethanol using the nematode worm, Caenorhabditis elegans. First, we explored the role of ethanol metabolism in acute behavior responses to ethanol. Natural variation in human ethanol metabolism machinery is one of the most reported and reproducible associations found to alter drinking behavior. Ethanol …
Multifunctional Orthogonally-Frequency-Coded Saw Strain Sensor, William Wilson
Multifunctional Orthogonally-Frequency-Coded Saw Strain Sensor, William Wilson
Theses and Dissertations
A multifunctional strain sensor based on Surface Acoustic Wave (SAW) Orthogonal Frequency Coding (OFC) technology on a Langasite substrate has been investigated. Second order transmission matrix models have been developed and verified. A new parameterizable library of SAW components was created to automate the layout process. Using these new tools, a SAW strain sensor with OFC reflectors was designed, fabricated and tested. The Langasite coefficients of velocity for strain (γS = 1.699) and Temperature (γT = 2.562) were experimentally determined. The strain and temperature characterization of this strain sensor, along with the coefficients of velocity, have been used to demonstrate …
Genetic Analysis Of Ethanol Sensitivity And Tolerance In Drosophila, Robin Chan
Genetic Analysis Of Ethanol Sensitivity And Tolerance In Drosophila, Robin Chan
Theses and Dissertations
The genetic pathways influencing alcohol abuse and dependence are poorly characterized. Many critical discoveries about the interactions between ethanol-related behaviors and genetics have been made in the fruit fly Drosophila melanogaster. Coupling the statistical power of model organism studies to human association studies bolsters the analytical efficacy of these genomic approaches. A variety of behavioral assays are available for assessing behavioral responses to ethanol in Drosophila. However, we find our previously described eRING assay is influenced by the commonly used transgenic marker mini-white. We developed a Simple Sedation Assay (SSA) that is insensitive to the effects of white and mini-white. …
Visual Attention Bias And Body Dissatisfaction In Eating Disorders, Janet Lydecker
Visual Attention Bias And Body Dissatisfaction In Eating Disorders, Janet Lydecker
Theses and Dissertations
Eating disorders, such as anorexia and bulimia nervosa, have profound negative effects on the quality of life of both affected individuals and their families. Behavioral approaches such as cognitive-behavioral therapy (CBT) are commonly used for the treatment of these disorders. CBT teaches skills to restructure maladaptive thought patterns as a method of altering feelings and behaviors. However, even after CBT, 50-70% of women with bulimia and 67-87% of women with anorexia report continued eating disordered thoughts, feelings and behaviors. Measuring underlying cognitive processes such as orienting, maintaining, and executive attention in individuals with eating disorder symptomatology might be an important …
The Effects Of Gain Of Function Mutant P53 And P63 On Eps8 And Cxcl5 Expression In Head And Neck Squamous Cell Carcinoma, Rubana Masood
The Effects Of Gain Of Function Mutant P53 And P63 On Eps8 And Cxcl5 Expression In Head And Neck Squamous Cell Carcinoma, Rubana Masood
Theses and Dissertations
Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers worldwide, with a survival rate of less than 50%. A class of mutant p53, known as gain of function (GOF) mutant p53, has been found to be expressed in tumors in these patients. GOF mutant p53 not only loses the wild type tumor suppressor functions, but also gains aberrant functions that have been linked to tumorigenesis. In this current study, we utilized a model system consisting of cells derived from HNSCC tumors in order to investigate our hypothesis that GOF mutant p53 enhances, and p63 …
Cannabinoids Delta-9-Tetrahydrocannabinol (Thc) And Cp55,940 Ablate Specific Chemokine And Cytokine Inflammatory Response In Bv-2 Mouse Microglial Cells Activated With Hiv-1 Pro-Inflammatory Protein Tat, Rebecca Maddux
Theses and Dissertations
Despite the widespread use of Highly Active Anti-retroviral Therapy (HAART) to combat Human Immunodeficiency Virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), HIV-Associated Neurocognitive Disorders (HANDs) still remain a dire issue. HIV can enter the brain through infected monocytes and infect microglia, the resident macrophages within that compartment. Due to its pro-inflammatory properties, HIV regulatory protein Tat (Transactivating protein) may play a role in the progression of neurocognitive disorders. The aim of this project was to determine whether the select cannabinoids THC and CP55,940 could ablate the inflammatory response on BV-2 mouse microglia cells caused by Tat. Within …
Structural Basis Of Dna Binding Complexes, Ninad Walavalkar
Structural Basis Of Dna Binding Complexes, Ninad Walavalkar
Theses and Dissertations
The nucleosome remodeling and deacetylase (NuRD) complex is an abundant deacetylase complex, which couples histone deacetylation and chromatin remodeling ATPase activities, and has a broad cellular and tissue distribution. Although the working model of how this complex forms and functions is not well known, we have demonstrated that the coiled-coil interaction between two proteins (MBD2 and p66α) is critical for DNA methylation dependent gene silencing in vivo. Chapter one: ‘Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and p66α dictate high affinity binding’ describes this unique coiled coil interaction. Coiled-coils were studied using …
Implications Of Child Abduction For Human Rights And Child Welfare Systems: A Constructivist Inquiry Of The Lived Experience Of Guatemalan Mothers Publically Reporting Child Abduction For Intercountry Adoption, Carmen Monico
Theses and Dissertations
The Hague Convention on the Protection of Children and Co-operation in Respect of Intercountry Adoption was agreed upon in 1993 at the Hague Conference on Private International Law to address growing allegations of abduction, sale, and trafficking of children around the world. The Hague Convention guides countries to attend to the “best interest of the child” in making decisions on intercountry adoptions, and to apply the “principle of subsidiarity,” which calls for the consideration of family and kinship placement and national adoption prior to the consideration of intercountry adoption. This dissertation research focused on the experience of Guatemalan mothers reporting …
Modular Envelops, Rotem Tamir
Modular Envelops, Rotem Tamir
Theses and Dissertations
This texts in about my thesis show; Modular envelopes which was presented in the Anderson gallery at may 2013. The text speaks about my individual process of making both this particular work and art in general.