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Lapatinib And Sorafenib Kill Gbm Tumor Cells In A Greater Than Additive Manner, Seyedmehrad Tavallai Nov 2013

Lapatinib And Sorafenib Kill Gbm Tumor Cells In A Greater Than Additive Manner, Seyedmehrad Tavallai

Theses and Dissertations

Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults, affecting thousands of people worldwide every year, with a life expectancy, post diagnosis of 12 months. Surgery, radiotherapy and chemotherapy together, result in an overall mean survival not exceeding 15 months. Targeted therapeutic agents sorafenib, an oral multi kinase inhibitor, and lapatinib, an epidermal growth factor receptor (EGFR) inhibitor, used in combination have been shown to kill GBM cells be through inhibition of major growth mediating signaling pathways that are frequently over expressed in gliomas, including mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase/ protein kinase B (PI3K/AKT). …

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Sirt6 And Premature Aging Of Hutchinson-Gilford Progeria Syndrome Fibroblasts., Helal Endisha Nov 2013

Sirt6 And Premature Aging Of Hutchinson-Gilford Progeria Syndrome Fibroblasts., Helal Endisha

Theses and Dissertations

The genetic disease Hutchinson-Gilford Progeria Syndrome (HGPS) arises from a de novo single nucleotide mutation (1824CàT) in the LMNA gene. As a result, the mutated lamin A protein (progerin) remains farnesylated and permanently attached to the nuclear membrane. Progerin accumulates and deforms the nuclear membrane leading to an array of cellular abnormalities driving the cells to enter a state of permanent cell-cycle arrest early on in replicative age i.e. premature cellular senescence. Cellular senescence has been extensively studied as one of the contributing factors to aging in HGPS patients and other age-related diseases. There has also been evidence to show …

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Variation And Modulation Of Micrornas In Prostate Cancer And Biological Fluids, Sarah Seashols Nov 2013

Variation And Modulation Of Micrornas In Prostate Cancer And Biological Fluids, Sarah Seashols

Theses and Dissertations

Prostate cancer is the second-most diagnosed and fatal carcinoma for males in the United States, and better diagnostic markers and potential therapies are needed. microRNAs are small, single-stranded RNA molecules that affect protein expression at the translational level, and dysregulation can dramatically affect cell metabolism. Comparison of 736 microRNA expression levels between the poorly metastatic SV40T immortalized prostate epithelial cell line P69 to its highly tumorigenic and metastatic subline M12 identified 231 miRs that were overexpressed and 150 miRs that showed loss of expression in the M12 cell line. Further evaluation of fourteen identified miRs was accomplished using other prostate …

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Community Participation In Disaster Planning And The Expectation Gap: Analysis And Recommendations, Phillip Sperry Nov 2013

Community Participation In Disaster Planning And The Expectation Gap: Analysis And Recommendations, Phillip Sperry

Theses and Dissertations

This thesis explores the expectation gap and how it relates to the field of emergency management. As disasters become more commonplace, many citizens have high expectations of their governments, which results in a lack of individual disaster preparation. This thesis analyzed the current state of community education and engagement programs, use of best practices by governments and inter-agency cooperation and partnerships. The research consisted of fifteen interviews with emergency management professionals representing local, state, and federal government as well as the private sector. The results show limited public participation, as well as issues with crisis communications systems. Over 80% of …

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"'Picture This:' Barbara Kruger's 'Imperfect Utopia'", Allie Craver Nov 2013

"'Picture This:' Barbara Kruger's 'Imperfect Utopia'", Allie Craver

Theses and Dissertations

California contemporary artist Barbara Kruger created the colossal, three-dimensional work "Picture This" as part of the winning outdoor park design "Imperfect Utopia" (1986-1997) held by the North Carolina Museum of Art in Raleigh. Situated in the landscape outside the museum’s original building designed by Edward Durell Stone, 80-foot-tall letters inscribe Kruger’s phrase "Picture This." The letters are embedded with quotations, historical markers, cultural figures, as well as elements pertaining to North Carolina’s history and environment. This thesis proposes that "Picture This" functions as Kruger’s conceptual critique of museums; more specifically, it critiques their traditional utopian goals and simulacral stature. This …

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Local Roots, National Trend: The Richmond Printmaking Workshop (1978-1991), Alicia Mccarty Nov 2013

Local Roots, National Trend: The Richmond Printmaking Workshop (1978-1991), Alicia Mccarty

Theses and Dissertations

The Richmond Printmaking Workshop (RPW) was in operation from 1978 to 1991 during a nationwide print revival. From the 1960s through the 1990s, hundreds of new printmaking workshops and cooperatives sprung up across the country. This newfound popularity in the medium led to a boom in the print market and resulted in widespread experimentation of the medium. The RPW, founded by artists Nancy David and Gail McKennis, began in response to these trends and demonstrates how the print resurgence operated on a local level. Like many other small printmaking workshops of the period, it provided printmaking equipment to artists and …

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Analysis And Construction Of Engaging Facial Forms And Expressions: Interdisciplinary Approaches From Art, Anatomy, Engineering, Cultural Studies, And Psychology, Leejin Kim Nov 2013

Analysis And Construction Of Engaging Facial Forms And Expressions: Interdisciplinary Approaches From Art, Anatomy, Engineering, Cultural Studies, And Psychology, Leejin Kim

Theses and Dissertations

The topic of this dissertation is the anatomical, psychological, and cultural examination of a human face in order to effectively construct an anatomy-driven 3D virtual face customization and action model. In order to gain a broad perspective of all aspects of a face, theories and methodology from the fields of art, engineering, anatomy, psychology, and cultural studies have been analyzed and implemented. The computer generated facial customization and action model were designed based on the collected data. Using this customization system, culturally-specific attractive face in Korean popular culture, “kot-mi-nam (flower-like beautiful guy),” was modeled and analyzed as a case study. …

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Commonwealth Times 2013-11-18 Nov 2013

Commonwealth Times 2013-11-18

Commonwealth Times, 1969-

No abstract provided.

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"To Preserve, Protect, And Pass On:" Shirley Plantation As A Historic House Museum, 1894–2013, Kerry Dahm Nov 2013

"To Preserve, Protect, And Pass On:" Shirley Plantation As A Historic House Museum, 1894–2013, Kerry Dahm

Theses and Dissertations

This thesis provides an analysis of Shirley Plantation’s operation as a historic house museum from 1894 to the present period, and the Carter family’s dedication to keeping the estate within the family. The first chapter examines Shirley Plantation’s beginnings as a historic house museum as operated by two Carter women, Alice Carter Bransford and Marion Carter Oliver, who inherited the property in the late nineteenth century. The second chapter explores Shirley Plantation’s development as a popular historic site during the mid-twentieth century to the early part of the twenty-first century, and compares the site’s development to the interpretative changes that …

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Participation In The Digital Public: New Media Art As Online Community, Vaughn Garland Nov 2013

Participation In The Digital Public: New Media Art As Online Community, Vaughn Garland

Theses and Dissertations

Participation in The Digital Public: New Media Art as Online Community examines community online art projects— works of art produced and orchestrated by artists who employ the interconnected and participatory nature of the Internet. Garland contends, in part through a reevaluation of a statement made by artist Nam June Paik concerning a radio performance by John Cage, that community online art projects exist as the newest example of new media art because of a utilization and implementation of established and functioning technology. Through the application of Internet technology, contemporary artists, along with their collaborators and spectators, have the potential to …

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Accidental Octopus, Elizabeth Patterson Nov 2013

Accidental Octopus, Elizabeth Patterson

Theses and Dissertations

I head to the ocean for inspiration. Diving deep, the diverse organic shapes and fluidity of the flora and fauna inspire me to create modular pieces that incorporate intricate line work. This repetitive line and patterning gives me peace and helps me meditate. This self-exploration has opened up a stimulating world that pushes me to produce prints and silver jewelry that are individual and introspective. I have learned that the journey has become the aspiration and the production, a gift.

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High Throughput Data Framework Based Characterization And Evaluations Of Thermobifida Fusca For Industrial Applications, Niti Vanee Nov 2013

High Throughput Data Framework Based Characterization And Evaluations Of Thermobifida Fusca For Industrial Applications, Niti Vanee

Theses and Dissertations

Cellulolytic organisms are being heavily studied for the production of biofuels, given that lignocellulosic biomass would be a cheap, abundant, and renewable starting material for chemical production. A challenge with cellulolytic microorganisms is that they are typically poorly characterized and often difficult to genetically manipulate. Our group focuses characterization and engineering of a thermophilic aerobic, cellulolytic actinobacterium, Thermobifida fusca. The wider range of optimal temperature and pH for the growth condition, besides the secretion of several group of cellulases, have made this microbe a potentially efficient host system for industrially application. After the development of first ever successful genetic manipulation …

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Beauty In A Crooked Line, Sarah Ramey Nov 2013

Beauty In A Crooked Line, Sarah Ramey

Theses and Dissertations

Experimentation is the beginning and end of all of my art. I examine the interactions of the materials that are involved in the journey of creativity. Typically, I begin a piece with an irregularly drawn line, using a white crayon to resist the media that I will later apply, thereby creating a negative line. This gestural line becomes an element that helps direct my intuitive mark-making. My process involves masking, using resists, and layering materials. I then remove the layers of media by scraping or sanding them away changing the texture of the paper. I am drawn to media that …

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Reflecting On The Ordinary, Linda Conti Nov 2013

Reflecting On The Ordinary, Linda Conti

Theses and Dissertations

My work is about valuing the ordinary moments in life that can be described as joyful, difficult, beautiful, painful, or even transcendent. My creativity arises from a need to tell the story of these moments, and to share my experience with others. These moments are often evidenced by the objects we leave behind. They are a testament to the life we have lived, or are now living. My attention to small, ordinary details includes honoring and remembering people who have died. They may be artists, writers, friends, or family members but it is important to me to record the unique …

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Older Msm And Hiv/Aids: A Grounded Theory Study To Inform Prevention, Johnnie O'Neal Nov 2013

Older Msm And Hiv/Aids: A Grounded Theory Study To Inform Prevention, Johnnie O'Neal

Theses and Dissertations

This study sought to increase knowledge as it relates to HIV-prevention for older adults, especially for MSM who are HIV-negative. In participating in this study, participants shared their experiences, stories and feelings related to their exposure to HIV and HIV-prevention initiatives. Using a Traditional Grounded Theory method, 22 interviews with older MSM were conducted with the aim of producing a theory that explained how these men lived prior to HIV, the different ways they responded to the onset of the virus, how they have lived their lives over the last three decades, and the extent to which the virus continues …

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Broken News: Market Segmentation And Selective Exposure In Online News, Deidra Lee Nov 2013

Broken News: Market Segmentation And Selective Exposure In Online News, Deidra Lee

Theses and Dissertations

Research has revealed that more Americans than ever are turning to the World Wide Web as their primary source for news and information instead of legacy media outlets such as printed newspapers and magazines and broadcast news. As more and more people rely on the Internet as a primary source for news, it is important to analyze the characteristics and content of online news to expose and correct problems associated with the practices that inform its production and presentation. There are several longstanding practices in the American journalistic tradition that have been adapted to the online news environment. The practices …

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Characterizing The Implementation Of Cbt For Youth Anxiety, Meghan Smith Nov 2013

Characterizing The Implementation Of Cbt For Youth Anxiety, Meghan Smith

Theses and Dissertations

Although evidence-based treatments (EBTs) often perform well in research settings, when EBTs are delivered in practice settings they sometimes fail to outperform usual care (UC). One reason for this could be that therapists in practice settings may not follow the EBT protocol as closely or may deliver more therapeutic interventions that align with other treatment domains. I tested this possibility in the context of cognitive-behavioral treatment (CBT) for youth anxiety by comparing how CBT was delivered in practice (i.e., community-based clinics) and research (i.e., lab) settings. A diverse sample of youth (aged 7-15) received one of two treatments to address …

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Commonwealth Times 2013-11-04 Nov 2013

Commonwealth Times 2013-11-04

Commonwealth Times, 1969-

No abstract provided.

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Ink (2013-11) Nov 2013

Ink (2013-11)

Ink, 2008-

The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.

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My Inner Mask, Genevieve Ivan Oct 2013

My Inner Mask, Genevieve Ivan

Theses and Dissertations

My work is comprised of masks. The indigenous power of masks inspires the spirit, energy, and soul of my work. I use masks to reveal my inner self, similar to how masks were used in ritual ceremonies in the ancient past. The masks that I create break the grounds of my physical containment and open the curtains of my creative energy and psychological chaos. They allow me to embrace my vulnerability and my strength. My work encompasses prints, paintings, and ceramic sculptures. I work expressively by layering the process of mark making in an intuitive manner. Each layer I create …

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Laser Vaporization Methods For The Synthesis Of Metal And Semiconductor Nanoparticles; Graphene, Doped Graphene And Nanoparticles Supported On Graphene, Parichehr Afshani Oct 2013

Laser Vaporization Methods For The Synthesis Of Metal And Semiconductor Nanoparticles; Graphene, Doped Graphene And Nanoparticles Supported On Graphene, Parichehr Afshani

Theses and Dissertations

The major objective of the research described in this dissertation is the development of new laser vaporization methods for the synthesis of metal and semiconductor nanoparticles, graphene, B- and N-doped graphene, and metal and semiconductor nanoparticles supported on graphene. These methods include the Laser Vaporization Controlled Condensation (LVCC) approach, which has been used in this work for the synthesis of: (1) gold nanoparticles supported on ceria and zirconia nanoparticles for the low temperature oxidation of carbon monoxide, and (2) graphene, boron- and nitrogen-doped graphene, hydrogen-terminated graphene (HTG), metal nanoparticles supported on graphene, and graphene quantum dots. The gold nanoparticles supported …

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Commonwealth Times 2013-10-28 Oct 2013

Commonwealth Times 2013-10-28

Commonwealth Times, 1969-

No abstract provided.

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The Nature Of Architecture, Andrew Cossaboon Oct 2013

The Nature Of Architecture, Andrew Cossaboon

Theses and Dissertations

I enjoy driving in the city. It makes me feel minuscule against the skyscrapers and monuments. I wonder about who has lived in the city and admire the craftsmanship, the creative design, and the intelligence it takes to engineer and build these structures. The clean lines, geometric shapes, and surface textures of the buildings inspire my works. My obsession with construction and architecture has driven my creativity. In ceramics, I reflect on architecture when forming vases and jars. I hand-build and wheel-throw my pieces, and add surface texture and lines reminiscent of stone and brickwork. Only white and black glazes …

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Commonwealth Times 2013-10-21 Oct 2013

Commonwealth Times 2013-10-21

Commonwealth Times, 1969-

No abstract provided.

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Proactive Transparency And Government Communication In The Usa And The Netherlands, H.J.M. (Erna) Ruijer Oct 2013

Proactive Transparency And Government Communication In The Usa And The Netherlands, H.J.M. (Erna) Ruijer

Theses and Dissertations

Proactive government transparency has recently entered the spotlight. Examples of information made public at the initiative of the public body, without the need for filing a request, are: www.data.gov and www.recovery.gov. Transparency is an intrinsic value of democratic societies. In much of the literature an automatic link is assumed between transparency and increased accountability or trust. However, this link may not be as straightforward. Whether and how information is used to further public objectives also depends on the way information is incorporated into the complex communication chain of comprehension, action and response. Therefore, in this dissertation a communication approach was …

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In-Between, Mary Buchanan Oct 2013

In-Between, Mary Buchanan

Theses and Dissertations

My artwork is about juxtaposition and the presence of conflict. I search for the sublime in the somber realities associated with health, aging, and vulnerability. The dualities involved in human mortality produce a tension that inspires me to create. I also explore the physical relationships between contrasting media, and attempt to resolve their differences. I use narrative devices as well as the formal elements of art to work through visual problems. Mood is suggested through texture, color, form, and quality of line. Symbolism consists of walkers, wheelchairs, hand tools, earrings, children's toys, vacuum cleaners, and human silhouettes. My quilted textiles …

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Commonwealth Times 2013-10-14 Oct 2013

Commonwealth Times 2013-10-14

Commonwealth Times, 1969-

No abstract provided.

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Commonwealth Times 2013-10-07 Oct 2013

Commonwealth Times 2013-10-07

Commonwealth Times, 1969-

No abstract provided.

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Commonwealth Times 2013-09-23 Sep 2013

Commonwealth Times 2013-09-23

Commonwealth Times, 1969-

No abstract provided.

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Modeling Effect Of Microstructure On The Performance Of Fibrous Heat Insulation, Raghu Arambakam Sep 2013

Modeling Effect Of Microstructure On The Performance Of Fibrous Heat Insulation, Raghu Arambakam

Theses and Dissertations

Heat insulation is the process of blocking the transfer of thermal energy between objects at different temperatures. Heat transfer occurs due to conduction, convection, or radiation, as well as any combination of these three mechanisms. Fibrous insulations can completely suppress the convective mode of heat transfer for most applications, and also help to reduce the conductive and radiative modes to some extent. In this study, an attempt has been made to computationally predict the effects of microstructural parameters (e.g., fiber diameter, fiber orientation and porosity) on the insulation performance of fibrous materials. The flexible simulation method developed in this work …

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