Digital Commons Network^™

Mir155, Triplicated In Down Syndrome, Regulates The Development Of Neural Stem Cells And Gabaergic Interneurons In Alzheimer's Disease Mouse And Human Ipsc Models., Xiaodong Zhu, Jean-Vianney Haure-Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al-Subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E Ehrlich

Faculty Research 2026

INTRODUCTION: Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown.

METHODS: We utilized in silico analyses of published databases, MIR155-deleted and -overexpressing human induced pluripotent stem cell (hiPSC)-derived cells, cortical organoids, and amyloid beta precursor protein (APP)/PS1-miR155 knockout mouse.

RESULTS: MIR155HG (miR155 host gene) colocalizes with APP in a neuron-specific, topologically associated domain (TAD) in chromosome 21. In human neural stem cells (NSCs), neurons, and cortical organoids, MIR155 deletion enhanced NSC proliferation and GABAergic interneuron generation. MIR155 overexpression inhibited NSC marker expression …

Inhibition Of Moesin And Cd44 In Stem Cell-Derived Neurons Affects The Pathological Genetic Signature Associated With Alzheimer's Disease., Eiden H Brewer, Charles A Williams, Gregory Cary, Ranjita Betarbet, Inez K A Pranoto, Elizabeth L Zoeller, Haian Fu, Allan I Levey, Jesse C Wiley, Gregory W. Carter, Jessica E Young, Treat-Ad Consortium

Faculty Research 2026

INTRODUCTION: Post mortem proteomic analysis of Alzheimer's disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced pluripotent stem cells (hiPSCs)-derived neurons, we assayed how reducing gene expression of MSN and CD44 affected amyloid beta secretion, tau phosphorylation, and transcriptional state.

METHODS: Knockdown of MSN and CD44 in hiPSC-derived neurons was performed using short hairpin RNA (shRNA). Amyloid precursor protein processing and intracellular tau phosphorylation was measured using chemiluminescent ELISA assays. Global gene expression was analyzed by bulk RNA sequencing (RNA-seq).

RESULTS: Knockdown …

The Internet Did This To Me: Forms, Consequences, And Coping Strategies Of Cyberbullying, Isaac Oppong

Electronic Theses and Dissertations

This study examined self-reported cyberbullying experiences recounted in a subreddit (r/cyberbullying) to identify forms of cyberbullying, its effects, and ways to cope with it. The findings indicate that there are several types of cyberbullying, such as verbal aggression, deceptive manipulation, privacy invasion, and coercive control. These experiences led to emotional, social, and behavioral consequences, including fear, anxiety, withdrawal, and decreased online activity. Based on concepts from Social Information Processing theory and Symbolic Interactionism, this study reveals how cyberbullying can produce the same or similar consequences as traditional bullying. People experienced disturbances in their self-presentation, contended with spoiled identities, and dealt …

A Scalable And Physically Interpretable Machine Learning Approach To Analyzing Agn Spectra, Liza Maria Matrecito Salcedo

Theses

The broad-line region (BLR) is a sub-parsec region in an Active Galactic Nucleus (AGN) where dense, optically thick gas clouds produce broad emission lines (BELs). BELs are important probes of physical processes near the central supermassive black hole (SMBH); however, a complete understanding of the BLR’s structure and dynamics remains lacking. The observed diversity in BEL profile shapes suggests substantial differences in BLR properties across AGN. The availability of large-scale spectroscopic databases provides a valuable opportunity to systematically study these properties in large samples of AGN. They also offer the opportunity to identify rare but important systems, such as SMBH …

Beyond The Binary: The Intersection Of Substance Use And Lgbtq+ Identity, Allyana Musa

Educational Specialist, 2020-current

Substance use among LGBTQ+ youth remains a significant public health concern, with rates of alcohol, marijuana, and other substance use consistently exceeding those of their heterosexual peers. This systematized review examines the literature on substance use interventions for LGBTQ+ youth, with a focus on identifying the program components and theoretical orientations associated with effective and affirming outcomes. Following PRISMA guidelines, a systematic search of ERIC and PsycINFO was conducted to identify peer-reviewed studies published between 2016 and 2026 that addressed substance use among LGBTQ+ youth. Eligible studies included quantitative, qualitative, mixed methods, and conceptual research examining substance use, risk and …

Supporting Every Student: Optimizing School-Based Mental Health Services For Students With Intellectual Disabilities, Sarah K. Eggleston

Educational Specialist, 2020-current

Youth with intellectual disabilities (ID) are at considerably greater risk of developing mental health problems compared with the general population; however, their needs are less likely to be identified, and they often face barriers to accessing quality mental health care. School-based mental health professionals (SBMHPs) are uniquely positioned to support students within their natural learning environments, where many common barriers to service provision have been removed. The present study examined the current state of practice among SBMHPs in Virginia in identifying and supporting the needs of students with ID, as well as SBMHPs’ training experiences. An online cross-sectional, mixed-methods survey …

Cartel Del Noreste And Human Smuggling: Understanding Modern Tactics: A React Case Study, Anjun Dhillon, Isaac J. Moelter

Reports, Projects, and Research

On August 23, 2026, three members of Cartel Del Noreste (CDN) attempted to smuggle three people across the U.S. southern border in Laredo, Texas. Francisco Suarez, age 20, along with Luis Daniel Segura Guzman, age 26, prepared to transport the group from Mexico to the United States. The cartel members used Facebook to advertise their transportation services and to recruit aliens who needed help. A third CDN member, Bernardo Aniceto Garza, age 27, was placed in charge of driving the vehicle.

Cellular Senescence Links Muscle Atrophy And Posttraumatic Osteoarthritis After Acl Injury, Alexander R. Keeble, Allison Owen, Sara Gonzalez-Velez, Nicholas T. Thomas, Camille R. Brightwell, Peyton J. Balawender, Madeline G. O'Daniel, Helena C. Weiss, Haley Noehren, Heather Thompson, Karen Sofia Zuluaga-Osorio, Zane T. Bates, Lauren Gottlieb, Douglas E. Long, Douglas Harrison, Philip Kern, Caitlin E. Conley, Michael A. Samaan, Stephen Duncan, Austin Stone, Darren Johnson, Yuan Wen, Brian Noehren, Cory Dungan, Christopher Fry

Biology Faculty Publications

Traumatic knee injury leads to posttraumatic osteoarthritis (PTOA) and significant skeletal muscle weakness, resulting in chronic disability. The current standard of care frequently fails to prevent musculoskeletal dysfunction, underscoring the need to identify therapeutic mechanisms of PTOA. Using an established preclinical anterior cruciate ligament (ACL) transection model of PTOA and leveraging an innovative SPiDER-senescence-associated β-galactosidase stain to discern senescent cells, we investigated cellular senescence at single-cell resolution and identified anti-inflammatory macrophages as a predominant contributor to the senescent cell burden in both muscle and knee joint after injury. Clearance of senescent cells using the senolytic dasatinib and quercetin (D + …

Aligned But Disengaged: Self-Estrangement Weakens Citizenship Behavior In Higher Education, Andrew Krouse, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

Higher education depends on discretionary employee contributions that sustain coordination, service continuity, and institutional functioning. Yet contemporary governance and accountability pressures can reconfigure higher education work in ways that erode autonomy, line-of-sight, and intrinsic reward, elevating the risk of work alienation, weakening the discretionary behaviors institutions rely on. This study tests whether person–organization fit (POF) predicts organizational citizenship behavior (OCB) and whether multidimensional work alienation mediates this relationship through powerlessness, meaninglessness, and self-estrangement. Using survey data from 325 employees across four U.S. higher education institutions, we applied confirmatory factor analysis and structural equation modeling with bias-corrected bootstrapping. Model comparisons were …

Teen Suicide And The Outcomes Of Surviving Peers, Emily Cuddy, Janet Currie, Elisa Jácome, Lucy Manly

Cowles Foundation Discussion Papers

By age 17, a quarter of U.S. students have experienced a peer suicide. Using linked administrative data from South Carolina and a matched difference-in-differences design, we find that exposure to a peer’s self-harm death increases the probability of a self-harm diagnosis by nearly 50% and both the incidence and frequency of mental health visits. Effects on care use and criminal behavior are concentrated among white boys, and responses diverge by prior mental health history: students without a prior diagnosis increase felony offending rather than care-seeking. Deaths from assault and transportation accidents produce no comparable rise in self-harm, consistent with contagion.

Know Your Birth, Jasmine Mckelvey, Reagan L. Hunt, Michaela M. David

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

Maternal mortality remains a significant public health concern in rural Kenya because of limited healthcare resources, inadequate emergency obstetric training, and barriers to accessing timely, high-quality maternal care. This quality improvement project evaluated the implementation of the Know Your Birth educational intervention, a culturally responsive, simulation-based training program designed to improve healthcare providers' knowledge, confidence, and competency in evidence-based maternal and newborn care. The project was conducted at Sega Dispensary in Sega, Siaya County, Kenya, and included 26 healthcare staff members. Guided by the Plan-Do-Study-Act framework, participants completed a brief educational presentation followed by three interactive skills stations focused on …

Sdrc Update (Volume 7, Issue 3), Dlsu Social Development Research Center

SDRC Publications

The August 2026 issue of SDRC Update highlights research that addresses emerging social and development challenges in the Philippines. This issue features the launch of the Towards Resilient Platform Work in the Philippines policy report, which presents recommendations on strengthening social protection and skills development for platform workers. It also showcases the Mind the Climate project, which examines the mental health impacts of climate change on Filipino youth living in climate-vulnerable communities. The issue concludes with a Researcher Spotlight on Ms. Ma. Angeles "Maeyet" G. Lapeña, recipient of the 2026 Evolutio Socialis Distinguished Researcher Award, recognizing her contributions to evidence-based …

A Stabilized Weighted Interior Penalty Method For Thermal Convection Model In Heterogeneous Porous Media, Yuanyuan Hou, Qianqian Ding, Xiaoming He, Yanping Lin

Mathematics and Statistics Faculty Research & Creative Works

In this article, we propose and analyze a stabilized weighted interior penalty method for solving the thermal convection problems in heterogeneous porous media. We first transform the thermal convection model into the pressure primal form with homogeneous Neumann boundary condition and develop a symmetric weighted interior penalty method to handle the discontinuous Darcy number and automatically adjust the penalty coefficient corresponding to the varying permeability. Then we recover the velocity by a stabilized method and incorporate it into the energy equation to obtain the temperature. The stability and convergence rates of the numerical solutions are rigorously proved and verified by …

The True Scope Of Trusting Your Gut: A Study Into The Enteric Nervous System And The Relationship Between The Gut-Brain Axis And The Mind, Bryan Pham

Theses & ETDs

Since the early days of medicine, the “gut” had been associated as a seat of emotions and intuition, but as modern science marched forward, the brain itself was given complete dominion over mental health. But thanks to research into the enteric nervous system (ENS), which innervates the digestive tract and bilaterally communicates with the brain as a secondary function, we now know that, in a sense, the gut does indeed have a substantial impact on mental health outside of its primary functions. This profound discovery could potentially cause a massive rewrite for decades of modern neuroscience-based medicine. Overall, the study …

Effective Strategies For Accessing Capital For Startup Agricultural Entrepreneurs In St. Vincent And The Grenadines, Tonya Pompey

Walden Dissertations and Doctoral Studies

Limited access to capital is a significant barrier to market entry and long term sustainability in the agricultural industry. Agricultural business owners consistently identify capital constraints as the leading predictor of startup failure. Grounded in institutional theory, the purpose of this qualitative pragmatic inquiry was to identify and explore effective strategies that agricultural startup business owners used to access capital for market entry and business sustainability. The participants were six agricultural startup entrepreneurs in St. Vincent and the Grenadines (SVG) who used effective strategies to access capital for market entry and sustained business operations for at least 2 years. Data …

Effective Strategies To Improve Ai Governance And Regulatory Compliance, Mursal Haroon

Walden Dissertations and Doctoral Studies

Senior business leaders across sectors face increasing risks because many organizations lack effective strategies to ensure transparency and regulatory accountability in artificial intelligence (AI) governance. This problem is critical for industry leaders who rely on transparent and compliant AI systems to protect consumers and maintain operational stability. Grounded in the ethical usage of AI systems, the purpose of this qualitative pragmatic study was to explore effective strategies senior business leaders use to improve transparency and regulatory accountability in AI governance. The participants were six senior business leaders in the United States who successfully implemented such strategies. Data were collected through …

2026-07-21 Executive Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

Exploring The Democracy And Climate Policy Nexus, Democracy Mechanisms, And Policy Volatility, Brenna Magliacane

Theses & ETDs

A growing area of climate research explores the forms of government best equipped to confront the climate crisis and shape long-term environmental policy. The theories amongst this research seem to advocate for polar solutions: authoritarianism or democracy. Climate change and related ecological challenges increasingly test the capacity of existing political systems to deliver timely and effective responses. This research project aims to answer the questions: To what extent does democracy influence the adoption and implementation of national climate policy? How do democracies and autocracies differ in the strength and durability of their climate policies? Investigating this relationship can inform future …

Experiential Learning In Child Life Education, Amanda L. Lockett

All Dissertations

Child life specialists support children and families during healthcare experiences and other stressful life events, making it important for child life students to develop both knowledge and practical skills before entering the profession. This study explored how current child life students and recent graduate experienced hands-on learning activities in their child life education. Through interviews, a survey, and follow-up reflection, participants described how activities like role play, case studies, realistic scenarios, activity play plans, and teaching plans influenced their learning and professional development. Participants shared these experiences helped them learn to apply what they learned in the classroom into real …

The Startup: Critical Perspectives On Technology Entrepreneurship And Digital Labor, Kochav Koren

All Duquesne Faculty Scholarship

Communication and media studies are rapidly reshaped by socio-technological forces within the framework of informational capitalism, where startups emerge as key drivers of the global creative economy. This study critically examines the global startup movement through political economy, classical sociology, and Southern perspectives to assess whether digital entrepreneurship fosters genuine, decentralized innovation or perpetuates speculative financialization and labor precarity. Employing a multi-layered theoretical framework—including Schumpeterian creative destruction, Marxist commodity fetishism, and Weberian charismatic authority—and qualitative fieldwork across North and Latin American tech hubs, the analysis reveals startups as network enterprises that both disrupt markets and reproduce structural inequalities. The findings …

Mckee Minute August 2026, Southern Adventist University

McKee Minute – McKee Library This Month

The August 2026 edition of McKee Minute includes information on information literacy scheduling, course reserves, SmartStart hours, and more.

Ai You Can Trust: Understanding The Role Of Structural Assurance And Situational Normality In The Use Of Generative Ai, Olushola Bunmi Abayomi

Dissertations

The rapid growth of generative artificial intelligence (GenAI) has increased its use in productivity, content creation, and decision support; however, adoption depends on user trust, as GenAI performs tasks that are often associated with human judgment. Drawing on the Trust in Technology Model, this dissertation examines how structural assurance and situational normality influence Trust in GenAI, and how Trust in GenAI affects trusting intentions and users' willingness to depend on GenAI. Structural assurance and situational normality, captured through several factors, were modeled as antecedents of Trust in GenAI and, in turn, trusting intentions. The model was tested using survey-based experimental …

Alaska Earthquake Center Quarterly Review October-December 2025, Heather Mcfarland, Beth Grassi, Austin Holland, Nate Murphy, Elisabeth Nadin, Carolyn Parcheta, Michael West

Alaska Earthquake Center Reports

This series of technical quarterly reports from the Alaska Earthquake Center (AEC) includes detailed summaries and updates on Alaska seismicity, the AEC seismic network and stations, fieldwork, our online presence, public outreach, and lists publications and presentations by AEC staff. Multiple AEC staff members contributed to this report.

Using Photovoice And Life Course Theory To Understand The Lived Experiences Of Filipino Teenage Parents, Nina Linly D. Capulong, Liane Peña Alampay, Bernice Landoy Mamauag, Jennel Drezza Fe C. Reyes

Psychology Department Faculty Publications

Teenage parents face the unique challenge of simultaneously navigating adolescence and parenthood. Rising adolescent pregnancy rates in the Philippines necessitate urgent efforts to better understand and support them. Using Photovoice, Filipino teenage parents captured their lived experiences through photographs, resulting in eight themes: (1) Managing stresses and conflicts in partner relationships, (2) Peers as a source of emotional support, (3) Support and strain in family relationships, (4) Shifts in normative adolescent experiences and priorities, (5) Strain and agency in balancing roles, (6) Desire to enhance parenting knowledge and skills, (7) Environmental drivers of early sexual exposure, (8) Sexual knowledge from …

The Misinterpretation Of “Corporation” In Indonesia’S Penal Code No. 1 Of 2023: Ensuring Legal Certainty For Recognized Corporate Forms, Rizaldy Alif Syahrial

Indonesia Law Review

Abstract

Law No. 1 of 2023 on the Indonesian Penal Code expands criminal liability to include entities that do not possess legal personality, allowing informal entities such as commanditaire vennootschappen (CV), partnerships (firm), unincorporated business groups, and unregistered associations to be prosecuted as corporations. This expansion aims to close legal loopholes in addressing modern criminal activity and to align Indonesia with global developments in corporate criminal liability. However, extending criminal liability to non legal persons generates conceptual tension because Indonesian legal doctrine distinguishes between natural persons and legal persons, which possess legal personality, decision making organs, separate assets, and autonomous …

Impact Of Media Guidelines On Suicide-Related Reporting Quality And Suicides: A Systematic Review And Meta-Analysis, Simone Scotti Requena, Vikas Arya, Thomas Niederkrotenthaler, Mark Sinyor, Michiko Ueda, Matthew J. Spittal, Jane Pirkis

Center for Policy Design and Governance

This brief summarizes "Impact of media guidelines on suicide-related reporting quality and suicides: A systematic review and meta-analysis," co-authored by Simone Scotti Requena, Vikas Arya, Thomas Niederkrotenthaler, Mark Sinyor, Michiko Ueda, Matthew J. Spittal, and Jane Pirkis in Crisis.

"Property Of The People" So Long As They Can Sue: How North Carolina's Public Records Law Fails To Account For Ignored Requests, Emily Christine Gajda

North Carolina Law Review

No abstract provided.

Harnessing Kenyan Aquaculture Through Social Media: Impacts, Challenges And Strategic Directions, Domitila Kyule, Jonathan Munguti, Mavindu Muthoka, Esther Magondu, Menaga Meenakshisundaram, Chrysantus M. Tanga, Kevin Obiero, Cecilia Githukia

All Peer-Reviewed Publications

Aquaculture is increasingly important for food, nutrition and livelihoods in Kenya, but the sector still faces persistent constraints in extension delivery, farmer learning, input access, market coordination and information reliability. This review examines how social media and related digital communication tools are shaping aquaculture development in Kenya, with attention to impacts, challenges, governance needs and strategic directions. A systematic literature review of studies and institutional sources published between 2015 and 2025 was conducted. The search identified 388 records, of which 45 sources were included in the final synthesis after screening, eligibility assessment and quality appraisal. Because the evidence was heterogeneous, …

History, Myth, Courage, And Selflessness: Kate Shelley And The Bridge Of Darkness, Stephen M. Jennings

All Theses

This thesis documents the research, creative development, and production of the animated short film Kate Shelley and the Bridge of Darkness. The project is inspired by the historical account of Kate Shelley, a fifteen-year-old girl who in 1881 crossed a railroad bridge during a violent storm near Moingona, Iowa, to warn a nearby train station of a catastrophic bridge collapse. Over time, Shelley’s actions became both a documented historical event and a subject of mythologized retellings in American cultural memory. The film explores this tension between history and legend through an interpretation that balances historical research with cinematic storytelling. The …

Painting A Scene: 3d Painterly Rendering From Curves To Rebelle, William M. Luttrell

All Theses

Stylized 3D rendering has seen much development and success over the past few years. From Spider-Man: Across the Spider-Verse to The Bad Guys, many studios have developed tools to incorporate stylistic elements from graphic novels, comic books, watercolor paintings, and more into their productions. This stylization process incorporates the pacing, visual style, and themes from the source medium into the animated work, allowing a much greater freedom of expression for artists and directors.

Inspired by these films as well as the needs of the short film Kate Shelley and the Bridge of Darkness currently in production, This paper presents …