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Swaying The Masses: The Effect Of Argument Strength And Linguistic Abstractness On Attitudes, Jessica Barber Apr 2009

Swaying The Masses: The Effect Of Argument Strength And Linguistic Abstractness On Attitudes, Jessica Barber

Theses and Dissertations

Two studies were conducted to investigate how the use of different types of language affects attitudes. Participants scrutinized arguments supporting a hypothetical toothpaste that differed in terms of argument strength (strong versus weak) and linguistic abstractness (abstract versus concrete) and subsequently evaluated the toothpaste. In addition, half of the participants in the second study were subjected to a cognitive load manipulation (i.e., rehearsing a ten-digit number) in order to limit their level of cognitive elaboration. Results indicated that strong arguments and those containing concrete descriptions led to more positive attitudes about the toothpaste, whereas weak messages comprised of abstract terms …

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Commonwealth Times 2009-04-23 Apr 2009

Commonwealth Times 2009-04-23

Commonwealth Times, 1969-

No abstract provided.

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Hyperspectral Reflectance For Rapid Viability Assessment Of Bacillus Endospores, Jarrod Edwards Apr 2009

Hyperspectral Reflectance For Rapid Viability Assessment Of Bacillus Endospores, Jarrod Edwards

Theses and Dissertations

A study was conducted to optically determine the viability of the Gram +, endospore-forming bacterial genera Bacillus using a hyperspectral reflectance spectrometer. Endospores are a dormant, differentiated cellular capsule form taken by select bacteria to ensure survival when environmental conditions become unfavorable. Two species of Bacillus were used for this study, Bacillus megaterium and Bacillus subtilis. These endospores were killed using a chemical treatment of sodium hypochlorite or a physical treatment of heat and pressure in an autoclave. The treated samples along with viable samples were lyophilized to form a powder. A reflectance spectrometer measuring 350 nm to 2500 nm …

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Structural And Functional Considerations In The Design Of Collagen-Based Electrospun Scaffolds, Chantal Ayres Apr 2009

Structural And Functional Considerations In The Design Of Collagen-Based Electrospun Scaffolds, Chantal Ayres

Theses and Dissertations

Electrospinning can be used to selectively process a variety of natural and synthetic polymers into highly porous scaffolds composed of nano-to-micron diameter fibers. This process shows great potential as a gateway to the development of physiologically relevant tissue engineering scaffolds. In this study we examine the structural and functional considerations regarding electrospun scaffolds for dermal template applications using novel quantification techniques. In order to characterize scaffold structure, a technique utilizing the fast Fourier transform was developed to systematically quantify fiber alignment and evaluate how different electrospinning parameters impact the structure and material properties of an electrospun scaffold. Gelatin was suspended …

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Salvinorin A: Fragment Synthesis And Modeling Studies, Donna Mcgovern Apr 2009

Salvinorin A: Fragment Synthesis And Modeling Studies, Donna Mcgovern

Theses and Dissertations

Salvinorin A is a non-nitrogenous, selective kappa opioid receptor agonist with potent hallucinogenic properties. Because Salvinorin A has no basic nitrogen, it does not readily adhere to the “message-address” concept of selectivity for the opioid receptors. Therefore, a better understanding of how salvinorin A and its analogs interact with the kappa opioid receptor may shed some light on how salvinorin A obtains its potency and selectivity. The structure-affinity relationships (SAFIR) of salvinorin A and its analogs along with a discussion of the selectivity of the opioid receptors, is presented. A fragment of salvinorin A, methyl-3-acetoxy-4-oxocyclohexanecarboxylate, was synthesized to determine if …

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Multisensory Input To The Lateral Rostral Suprasylvian Sulcus (Lrss) In Ferret, Elizabeth Hagood Apr 2009

Multisensory Input To The Lateral Rostral Suprasylvian Sulcus (Lrss) In Ferret, Elizabeth Hagood

Theses and Dissertations

For the brain to construct a comprehensive percept of the sensory world, information from the different senses must converge onto individual neurons within the central nervous system. As a consequence, how these neurons convert convergent sensory input into multisensory information is an important question facing neuroscience today. Recent physiological studies have demonstrated the presence of a robust population of multisensory neurons in the lateral bank of the rostral suprasylvian sulcus (LRSS) in adult ferret (Keniston et al, 2008). The LRSS is a region situated between somatosensory and auditory cortices, where bimodal (somatosensory-auditory) neurons occupy the greatest percentage of the sensory-responsive …

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The Presence Of Amphibian Ranavirus In Virginia Warm Water Fish Hatchery Ponds, Elizabeth Nelson Apr 2009

The Presence Of Amphibian Ranavirus In Virginia Warm Water Fish Hatchery Ponds, Elizabeth Nelson

Theses and Dissertations

Amphibian declines have been occurring world wide over the past several decades. Infectious disease and environmental changes have been implicated as the causative agents in these declines. Fish stocking from hatcheries provides a unique opportunity for organisms, including infectious diseases, to travel over long distances. Ranavirus was previously found in two ponds at Harrison Lake National Fish Hatchery in Charles City County, Virginia. Therefore, the primary objective of this study was to determine if ranavirus is present in tadpoles from four warm water fish hatcheries in Virginia. A secondary objective of this study was to determine if there are relationships …

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An Evaluation Of The Virginia 2002 Child Passenger Safety Law: Determining If The Law Reduced Motor Vehicle Crash Injuries And Fatalities, Petra Connell Apr 2009

An Evaluation Of The Virginia 2002 Child Passenger Safety Law: Determining If The Law Reduced Motor Vehicle Crash Injuries And Fatalities, Petra Connell

Theses and Dissertations

In 2002, Virginia increased the age that children needed to be restrained in a child safety seat from age three to age five. Employing a pre and post intervention analysis, this study evaluated the 2002 Virginia child safety restraint law and determined if the number and severity of motor vehicle crash injuries to children ages four and five changed significantly post-law. Two groups of children, children under age four and children ages six and seven, were utilized as control groups. Motor vehicle crash injury and death data from the Virginia Department of Motor Vehicles police crash report file, Virginia Health …

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Comparative Analysis Of Torsional Strength Between Profile® Gt® And Gt® Series X(Tm) Nickel Titanium Rotary Instruments, Jake Reynolds Apr 2009

Comparative Analysis Of Torsional Strength Between Profile® Gt® And Gt® Series X(Tm) Nickel Titanium Rotary Instruments, Jake Reynolds

Theses and Dissertations

The purpose of this study was to compare the resistance to fracture by the twisting of two nickel titanium (NiTi) rotary file systems. The Profile® GT® (GT) and the GT® Series X(TM) (GTX) files were tested to analyze the maximum torsional strength and the maximum angular deflection at the time of separation of the files. For each system, ten new files were tested at each of the following eight taper/size designations for a total of 160 files: 20/0.04, 20/0.06, 30/0.04, 30/0.06, 30/0.08, 40/0.04, 40/0.06, and 40/0.08. The American National Standards Institute / American Dental Association Specification No. 28 was implemented …

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Comparing Cyclic Fatigue Of The New Gt® Series X(Tm) Files To The Endo Sequence™ Rotary Instruments, Nathan Wayment Apr 2009

Comparing Cyclic Fatigue Of The New Gt® Series X(Tm) Files To The Endo Sequence™ Rotary Instruments, Nathan Wayment

Theses and Dissertations

The purpose of this study was to examine the number of rotations to failure of two different rotary file systems, EndoSquence Brassler USA (Savannah, GA) and GT(TM) series X(TM). Files sizes 20,30,40 with 0.04, 0.06 tapers of GT series X and Endo Sequence files size and taper used were 20, 30, 40 with 0.04 and 0.06 taper. Like tip and tapers were compared between systems. All files tested were 25mm in length. Files were allocated into 12 groups of 10 files each, and mounted to a universal testing machine. Each file was rotated at 300 rpms until fractured occurred. The …

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Comparing Cyclic Fatigue Of The New Gt® Series Xtm Files To The Original Profile® Gt® Rotary Instruments, Steven Osmond Apr 2009

Comparing Cyclic Fatigue Of The New Gt® Series Xtm Files To The Original Profile® Gt® Rotary Instruments, Steven Osmond

Theses and Dissertations

The purpose of this study was to test the number of rotations to fracture of the M-Wire GT® Series X(TM) rotary files compared to the original ProFile® GT® rotary files in a simulated curved canal. Eighty GT® Series X(TM) files of 25mm length were divided into eight groups of ten, one for each of the new GT® Series X(TM) files. Eighty original ProFile® GT® files of 25mm length were divided into eight groups of the same tip and taper sizes consistent with the GT® Series X(TM) file groups. Files were rotated at 300 rpm. While the angle may have slightly …

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Efficacy Of A Brief Intervention For Insomnia Among Psychiatric Outpatients, James Nile Wagley Apr 2009

Efficacy Of A Brief Intervention For Insomnia Among Psychiatric Outpatients, James Nile Wagley

Theses and Dissertations

Psychiatric patients are particularly affected by symptoms of insomnia. Because insomnia is often secondary to other conditions and was once thought to be less treatable, this condition has received little attention in terms of treatment and research. Additionally, psychiatric patients have typically fewer resources to seek treatment. Generally, insomnia is treated with medications that may have biological side effects and offer little restorative sleep. Behavioral or cognitive interventions have often been overlooked. This experiment uses profile analysis to test the hypothesis that psychiatric outpatients randomized to a treatment group would have decreased levels of sleep difficulties (measured by PSQI) when …

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Commonwealth Times 2009-04-20 Apr 2009

Commonwealth Times 2009-04-20

Commonwealth Times, 1969-

No abstract provided.

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Role Of Bcl-2 Family Members To Promote Glucocorticoid –Induced Apoptosis By Mek Inhibitors In Leukemic Cells, Anila Rambal Apr 2009

Role Of Bcl-2 Family Members To Promote Glucocorticoid –Induced Apoptosis By Mek Inhibitors In Leukemic Cells, Anila Rambal

Theses and Dissertations

Glucocorticoids (GC) are common components of many chemotherapeutic regimens for lymphoid malignancies. GC-induced apoptosis involves an intrinsic BCL-2 family-regulated pathway. It has been shown that BIM (BCL-2 interacting mediator of cell death), a BH3-only pro-apoptotic protein, is up-regulated by dexamethasone (Dex) treatment in acute lymphoblastic leukemia (ALL) cells. Furthermore, BIM is inactivated by extracellular signal-regulated kinase (ERK)-mediated phosphorylation. We therefore hypothesized co-treatment with Dex and MEK/ERK inhibitors would promote apoptosis in ALL cells through BIM up-regulation and activation. We show here that a MEK inhibitor, PD184352 synergistically enhances Dex lethality in CCRF-CEM (T-ALL) cells. Co-treatment with Dex and PD184352 results …

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The Role Of Acanthamoeba Culbertsoni Serine Proteases In Abating Microglial-Like Cell Cytokines And Chemokines, Jenica Harrison Apr 2009

The Role Of Acanthamoeba Culbertsoni Serine Proteases In Abating Microglial-Like Cell Cytokines And Chemokines, Jenica Harrison

Theses and Dissertations

Acanthamoeba culbertsoni is an opportunistic free-living amoeba that is causative of granulomatous amoebic encephalitis (GAE), a chronic and often fatal central nervous system (CNS) disease that is most prevalent in immune compromised individuals. One hallmark of this disease is the formation of granulomas within the CNS, which are commonly absent in immune compromised individuals. Granulomas are usually composed of amoebae, microglia (CNS macrophages), macrophages, T cells, B cells, and neutrophils. Previous studies have demonstrated that microglia respond to Acanthamoeba by producing pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF)-α, interleukin (IL)-1α, and IL-1β. In addition, activated microglia and macrophages …

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Intake Decision Making In Child Protective Services: Exploring The Influence Of Decision-Factors, Race, And Substance Abuse, Michael Howell Apr 2009

Intake Decision Making In Child Protective Services: Exploring The Influence Of Decision-Factors, Race, And Substance Abuse, Michael Howell

Theses and Dissertations

Child protective services begin with an intake (screening) decision to accept or reject maltreatment reports. This crucial decision may lead to significant positive or negative outcomes for children and families. Little is known about characteristics that intake decision-makers share or factors that influence the decision-making process. Racially-biased intake practices have been blamed for contributing to African American children’s disproportionate overrepresentation in the child welfare system. Concerns have emerged that social workers may hold negative stereotypes about African Americans and parents who use drugs. Stereotypical biases may influence decisions in reports alleging parental drug use and/or involving African American families. This …

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Commonwealth Times 2009-04-16 Apr 2009

Commonwealth Times 2009-04-16

Commonwealth Times, 1969-

No abstract provided.

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Coupling Of Autotrophic And Heterotrophic Plankton Food Web Components In The Tidal-Freshwater James River, Usa, Matthew Beckwith Apr 2009

Coupling Of Autotrophic And Heterotrophic Plankton Food Web Components In The Tidal-Freshwater James River, Usa, Matthew Beckwith

Theses and Dissertations

Empirical studies have shown that algal- and detrital-based food web components are coupled in many pelagic systems as algal carbon enhances bacterioplankton production and growth efficiencies. Such phyto-bacterioplankton coupling impacts carbon flow through plankton food webs, yet the extent of coupling is poorly understood in systems receiving large amounts of allochthonous carbon. To investigate this issue, bacterioplankton abundance (BA) and community composition were compared to chlorophyll a concentrations and phytoplankton production in the tidal-freshwater James River (VA). BA averaged 107 cells mL-1 and was significantly related to chlorophyll a, phytoplankton production, and DOC concentrations. Analysis of DOC quality using fluorescence …

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Therapeutic Drugs In Cancer, Teneille Walker Apr 2009

Therapeutic Drugs In Cancer, Teneille Walker

Theses and Dissertations

The first study examined the interaction between low doses of the multi-kinase inhibitor sorafenib and the histone deacetylase inhibitor vorinostat in colon cancer cells. Sorafenib and vorinostat synergized to kill HCT116 and SW480 cells. In SW480 cells, sorafenib+vorinostat toxicity correlated with CD95 activation and CD95-stimulated autophagy. Drug lethality in SW480 cells was blocked by knock down of CD95. In SW620 cells that are patient matched to SW480 cells, sorafenib+vorinostat toxicity was significantly reduced that correlated with a lack of CD95 activation and lower expression of ceramide synthase 6 (LASS6). Overexpression of LASS6 in SW620 cells enhanced drug-induced CD95 activation and …

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Effects Of Mentoring On The Development Of Leadership Self-Efficacy And Political Skill, Suzzette Chopin Apr 2009

Effects Of Mentoring On The Development Of Leadership Self-Efficacy And Political Skill, Suzzette Chopin

Theses and Dissertations

This study considered the effects of mentoring on protégés’ beliefs in their abilities to be leaders and on their development of interpersonal skills. This study explored, in 260 business graduate students, the relationship between (a) mentoring and leadership self-efficacy and (b) mentoring and political skill. Participants completed surveys including the Self-Efficacy for Leadership Scale, the Political Skill Inventory, and the Mentoring Functions Questionnaire. Comparisons between non-mentored and mentored individuals showed that having a mentor is associated with increased political skill (p < .05) but not increased leadership self-efficacy (p > .05). Among mentored individuals, higher quality mentoring relationships are associated with significantly higher leadership-self efficacy (p < .01) but not with significantly higher political skill (p > .05). The presence …

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Genetic Variations Of Cyp2b6 Enzyme And The Response To Meperidine In Oral Sedation, Sally Hua Apr 2009

Genetic Variations Of Cyp2b6 Enzyme And The Response To Meperidine In Oral Sedation, Sally Hua

Theses and Dissertations

Purpose: The purpose of this study was to determine the relationship of CYP2B6 genotype to the clinical response to meperidine in pediatric dental patients. Methods: Twenty-five patients, ASA I/ II, 45–92 months old, received an oral sedative regimen containing meperidine for dental treatment. The North Carolina Behavior Rating Scale (NCBRS) and Overall Effectiveness of Sedation Scale (OESS) were used to assess their behavior and sedation outcome. Saliva DNA samples were genotyped by PCR-RFLP. Results: We found the following genotype distributions: homozygous wild-type 1*1 (n = 8, 32%), heterozygous 1*6 (n = 13, 52%), and homozygous variant 6*6 (n = 4, …

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Molecular Mechanisms For Regulation Of Gene Expression By Lysophosphatidic Acid In Ovarian Carcinoma Cells, Regina Oyesanya Apr 2009

Molecular Mechanisms For Regulation Of Gene Expression By Lysophosphatidic Acid In Ovarian Carcinoma Cells, Regina Oyesanya

Theses and Dissertations

Lysophosphatidic acid (LPA) is a potent bioactive phospholipid mediator that functions through multiple G protein couple receptors (GPCRs). LPA is elevated in ascites of ovarian cancer patients and is involved in growth, survival and metastasis of ovarian cancer cells. Gene promoter analyses revealed that some LPA-target genes share similar sets of binding sites for prominent transcription factors posing the possibility of a general mechanism for activation of their expression by LPA. Detailed investigation of the mechanisms of regulation of cyclooxygenase 2 (Cox-2), a paradigm of LPA-regulated genes, showed that LPA robustly upregulated the expression of Cox-2 in ovarian cancer cells …

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The Effects Of Motivational Interviewing In Pregnancy On Infant Oral Health Knowledge And Behavior, Patricia Arteaga Apr 2009

The Effects Of Motivational Interviewing In Pregnancy On Infant Oral Health Knowledge And Behavior, Patricia Arteaga

Theses and Dissertations

Purpose: The purpose of this study is to examine infant oral health knowledge and readiness of expectant mothers to incorporate preventive oral health behaviors for their infants. Methods: The study used a prospective cohort design to examine the effect of prenatal education and motivational counseling with expectant mothers about infant oral health care readiness. Participants were all enrolled in a prenatal care program called Centering Pregnancy offered by VCU’s Department of Obstetrics and Gynecology. They all completed a pre-survey questionnaire, followed by a motivational counseling intervention, and then completed a post-survey questionnaire. Results: A sample of 30 pregnant women completed …

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Preventive Dental Services For Infants And Subsequent Utilization Of Dental Services, Elizabeth Berry Apr 2009

Preventive Dental Services For Infants And Subsequent Utilization Of Dental Services, Elizabeth Berry

Theses and Dissertations

The purpose of this study was to examine the use of dental services for young children following a preventive oral health intervention in a pediatric medical clinic. Over a 3 year period (2005-2008), children 0-36 months of age, enrolled in Medicaid, were provided preventive oral health services in a medical setting. Descriptive statistics and multivariate logistic regression were used to determine the effect receiving the preventive oral health services in a medical setting with the outcomes of dental utilization. 15% were determined to have dental caries at the intervention and 42% found to have a dental visit post-intervention. Children determined …

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The Role Of Myeloid-Derived Suppressor Cells In The Immunotherapy Of Breast Carcinomas, Johanna Morales Apr 2009

The Role Of Myeloid-Derived Suppressor Cells In The Immunotherapy Of Breast Carcinomas, Johanna Morales

Theses and Dissertations

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells at various stages of differentiation. These cells are broadly characterized by the simultaneous expression of the surface markers CD11b and Gr1 and have been found to accumulate in large numbers in response to many different tumors in both mice and humans, including HER2/neu+ breast cancers. The adoptive immunotherapy of cancers has been a promising field, yet the clinical efficacy of adoptive immunotherapies targeted against human breast cancers and many other cancers has been extremely limited. Given the influx of MDSC in tumor-bearing individuals, we hypothesized that these cells were …

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Botulinum Toxin For Non-Surgical Lateral Release In Subjects With Patellofemoral Pain, Laura Maple Apr 2009

Botulinum Toxin For Non-Surgical Lateral Release In Subjects With Patellofemoral Pain, Laura Maple

Theses and Dissertations

Previous studies for treating Patellofemoral Pain Syndrome (PFPS) are controversial regarding the effectiveness in alleviating anterior knee pain (AKP). The muscular imbalance between the vastus medialis oblique/vastus lateralis (VMO/VL) may be the underlying mechanical issue causing PFPS. It is hypothesized that Botox can decrease the force production capability of the lateral musculature mechanically similar to surgery. Strengthening the VMO while using Botox treatment can alleviating the muscular imbalance that occurs with subjects with PFPS. A double blind study, having all participants blinded and uninformed of the injection contents, was implemented to test this hypothesis testing three female subjects. Four knees …

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Youth Leadership Development And Peer-Led Initiatives, Kathryn Conley Apr 2009

Youth Leadership Development And Peer-Led Initiatives, Kathryn Conley

Theses and Dissertations

The current study explored the experiences of high school peer leaders (N = 45) chosen to participate in an eight-week peer-led tobacco intervention program, Living Free of Tobacco, Plus! (LIFT+). The study used a repeated measures design to examine changes in leadership self-efficacy, perceived leadership skill, and goal-setting from baseline to post-test. Leaders’ susceptibility to future tobacco use, self-efficacy to resist and avoid tobacco, and confidence and interest in following nutritional guidelines were also examined at two time points. To strengthen self-report measures, peer and teacher evaluations of observed leadership behavior were collected. Results suggest that participation as a peer-leader …

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Cannabinoid Effects On Nfkappab Function In Microglial-Like Cells: Dual Mode Of Action, Latoya Griffin-Thomas Apr 2009

Cannabinoid Effects On Nfkappab Function In Microglial-Like Cells: Dual Mode Of Action, Latoya Griffin-Thomas

Theses and Dissertations

Cannabinoids have been shown to modulate the immune system in vitro and in animal models. A major area of interest is how cannabinoids impact the brain. A whole variety of neuropathies or brain disorders, such as AIDS dementia, Parkinson’s disease, Multiple Sclerosis and Alzheimer’s disease, are associated with a hyperinflammatory response within the brain. Microglia, the resident macrophages of the brain, are the major cell type responsible for the persistent elicitation of pro-inflammatory cytokines (IL-1a, IL-1b, IL-6, TNFa) and other mediators. In vitro experiments have demonstrated that the partial exogenous cannabinoid agonist delta-9-tetrahydrocannabinol (D9-THC) and the potent synthetic exogenous cannabinoid …

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Onye Mbu: 'My Identity' Pedagogical Applications Of The Surreal And Absurd In Adrienne Kennedy's Funnyhouse Of A Negro, Adanma Onyedike Apr 2009

Onye Mbu: 'My Identity' Pedagogical Applications Of The Surreal And Absurd In Adrienne Kennedy's Funnyhouse Of A Negro, Adanma Onyedike

Theses and Dissertations

ONYE MBU: MY IDENTITY PEDAGOGICAL APPLICATIONS OF THE SURREAL AND ABSURD IN ADRIENNE KENNEDY'S FUNNYHOUSE OF A NEGRO By Adanma N. Onyedike, M.F.A A thesis submitted in partial fulfillment of the requirements for the degree of Master of Fine Arts at Virginia Commonwealth University. Virginia Commonwealth University, 2009 Major Director: Dr. Noreen Barnes, Director of Graduate Studies Department of Theater This document investigated my personal journey of discovering, developing, and later executing skill in teaching the theatrical arts. The re examination of the steps that led to my current success was important in order to qualify the receiving of my …

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Frontline Nursing Leaders And Staff Retention In An Acute Care Community Hospital, Beth Torres Apr 2009

Frontline Nursing Leaders And Staff Retention In An Acute Care Community Hospital, Beth Torres

Theses and Dissertations

The current and projected nursing shortage makes it imperative for healthcare organizations to examine factors that promote staff retention. Previous studies identify nursing leadership as a key component influencing staff retention and turnover. This study supplements these studies by identifying key behaviors and attitudes of frontline nursing leaders that influence staff retention. Using a grounded theory qualitative approach, the researcher interviewed 19 frontline nursing leaders in an acute care community hospital. The researcher also explored the extent to which nursing leaders felt current leadership education and training programs support their practices that promote staff retention. The goal of the study …

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