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Self-Forgiveness Interventions For Women Experiencing A Breakup, Kathryn Campana Apr 2010

Self-Forgiveness Interventions For Women Experiencing A Breakup, Kathryn Campana

Theses and Dissertations

This study examined the effectiveness of an intervention designed to increase self forgiveness for women who have recently experienced a romantic relationship breakup. Of particular interest were the interactions between adult attachment style, treatment condition, and time. The current study examined how the following variables differ between attachment style groups and how they change over time with respect to treatment condition: aspects of the former relationship, emotional responses to personal transgressions within the relationship, general negative and positive affect, dispositional forgivingness, positive and negative attitudes toward self, feelings of unforgiveness toward self and ex-partner, and feelings of forgiveness of self …

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A Numerical Method For Estimating The Variance Of Age At Maximum Growth Rate In Growth Models, Semhar Ogbagaber Apr 2010

A Numerical Method For Estimating The Variance Of Age At Maximum Growth Rate In Growth Models, Semhar Ogbagaber

Theses and Dissertations

Most studies on maturation and body composition using the Fels Longitudinal data mention peak height velocity (PHV) as an important outcome measure. The PHV is often derived from growth models such as the triple logistic model fitted to the stature (height) data. The age at PHV is sometimes ordinalized to designate an individual as an early, average or late maturer. In theory, age at PHV is the age at which the rate of growth reaches the maximum. Theoretically, for a well behaved growth function, this could be obtained by setting the second derivative of the growth function to zero and …

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Commonwealth Times 2010-04-22 Apr 2010

Commonwealth Times 2010-04-22

Commonwealth Times, 1969-

No abstract provided.

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Development Of Mechanical Cardiovascular Assist Devices For Fontan Patients: Two Novel Approaches, Sonya Bhavsar Apr 2010

Development Of Mechanical Cardiovascular Assist Devices For Fontan Patients: Two Novel Approaches, Sonya Bhavsar

Theses and Dissertations

Few therapeutic alternatives exist for patients with a failing single ventricle physiology. To address this need, this thesis project investigated two new therapeutic alternatives, which sought to positively augment the Fontan hemodynamics. The first modality introduced a non-invasive method of external pressure application to the lower extremities. A clinical study (n=2) was conducted, and results indicated an increase in flow as a consequence to an increase in transmural pressure in the lower extremities. The second modality investigated a minimally invasive blood pump. Numerical analyses of the pump were performed to examine hydraulic performance under physiologic conditions. The pump produced pressure …

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Death Notification Skills, Secondary Stress, And Compassion Fatigue In A Level One Urban Trauma Center, Enid Virago Apr 2010

Death Notification Skills, Secondary Stress, And Compassion Fatigue In A Level One Urban Trauma Center, Enid Virago

Theses and Dissertations

Abstract This quasi-experimental design study compared two small samples of Emergency medicine residents after one group had an educational intervention on death notification skills and the other did not. Comparisons were made on residents’ confidence in their communication, interpersonal skills and level of compassion fatigue/satisfaction and EM Residents’ level of Secondary Traumatic Stress after an event of patient death and subsequent notification of Secondary Patients. Residents were interviewed to gather recommendations for designing death notification curriculum. Over an eight month period, forty emergency medicine residents at two sites, control and intervention, completed surveys designed to provide quantitative data on self-confidence …

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Particle Image Velocimetry Measurements Of The Total Cavopulmonary Connection With Circulatory Flow Augmentation, Steven Chopski Apr 2010

Particle Image Velocimetry Measurements Of The Total Cavopulmonary Connection With Circulatory Flow Augmentation, Steven Chopski

Theses and Dissertations

This thesis project examined the interactive fluid dynamics between a blood pump and the univentricular Fontan circulation. 2-D particle image velocimetry (PIV) measurements were conducted on an idealized total cavopulmonary connection (TCPC) with an axial pump prototype in the inferior vena cava (IVC). Fluid velocity profiles were examined under various physiologic conditions for Fontan patients. The velocity profiles for all cases demonstrated the shunting of flow from the IVC toward the right pulmonary artery. A rotational component in the pump outflow was observed forcing flow to the periphery as compared to the flow profile without a pump present in the …

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Characterization Of The Staphylococcus Aureus Immunodominant Surface Antigen B, Isab, Nicole Lawrence Apr 2010

Characterization Of The Staphylococcus Aureus Immunodominant Surface Antigen B, Isab, Nicole Lawrence

Theses and Dissertations

Staphylococcus aureus is a significant cause of morbidity and mortality world-wide. This opportunistic pathogen is capable of causing several severe diseases that are exacerbated by its diverse and widespread antibiotic resistance profile. Therefore it is necessary to identify novel therapeutic targets to effectively treat S. aureus disease. Lorenz et al first described the Immunodominant Surface Antigen B, IsaB, because it was 1 of 4 unique proteins immunogenic during septicemia and not colonization, suggesting that IsaB may be a virulence factor and a possible novel therapeutic target. Interestingly, IsaB has no homology to proteins of known function and appears to be …

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Genetic Variations Of Cyp2b6 Enzyme And The Response To Meperidine In Oral Sedation, Heath Whitfield Apr 2010

Genetic Variations Of Cyp2b6 Enzyme And The Response To Meperidine In Oral Sedation, Heath Whitfield

Theses and Dissertations

Purpose: The purpose of this study was to determine the relationship of the CYP2B6 genotype to the clinical response to meperidine in pediatric dental patients. Methods: Forty-nine patients, ASA I/ II, 41–101 months old, received an oral sedative regimen containing meperidine for dental treatment. The North Carolina Behavior Rating Scale (NCBRS) and Overall Effectiveness of Sedation Scale (OESS) were used to assess their behavior and sedation outcome. Saliva DNA samples were genotyped by PCR-RFLP. Results: We found the following genotype distributions: homozygous wild-type 1*1 (n = 19, 39%), heterozygous 1*6 (n = 25, 51%), and homozygous variant 6*6 (n = …

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The Effects Of Motivational Interviewing In Pregnancy On Knowledge And Retention Of Infant Oral Health Information, Andrew Zima Apr 2010

The Effects Of Motivational Interviewing In Pregnancy On Knowledge And Retention Of Infant Oral Health Information, Andrew Zima

Theses and Dissertations

THE EFFECTS OF MOTIVATIONAL INTERVIEWING IN PREGNANCY ON KNOWLEDGE AND RETENTION OF INFANT ORAL HEALTH INFORMATION By Andrew D. Zima, Jr., B.S., M.S., D.D.S. A thesis submitted in partial fulfillment of the requirements for the degree of Masters of Science in Dentistry at Virginia Commonwealth University. Virginia Commonwealth University, 2010 Major Director: Tegwyn H. Brickhouse, D.D.S., Ph.D Associate Professor, Department of Pediatric Dentistry Purpose: The purpose was to examine the effect of motivational counseling in pregnancy with readiness and acceptance of infant oral health information. Methods: The study used a prospective cohort design to examine the effect of prenatal education …

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Differential Roles Of The Two Major Endocannabinoid Hydrolyzing Enzymes In Cannabinoid Receptor Tolerance And Somatic Withdrawal, Joel Schlosburg Apr 2010

Differential Roles Of The Two Major Endocannabinoid Hydrolyzing Enzymes In Cannabinoid Receptor Tolerance And Somatic Withdrawal, Joel Schlosburg

Theses and Dissertations

While there is currently active debate over possible therapeutic applications of marijuana and cannabis-based compounds, consistently their primary drawbacks have been the psychoactive properties, dependence, and abuse potential. Prolonged administration of ∆9-tetrahydrocannabinol (THC), the primary psychoactive constituent in marijuana, demonstrates both tolerance and physical withdrawal in both preclinical and clinical studies. Repeated THC administration also produces CB1 receptor adaptations in the form of reduced activation of receptors, along with a downregulation of membrane surface receptors, in many brain regions involved in THC-associated behaviors. The increased need for drug to maintain therapeutic effects, and a withdrawal syndrome following discontinuation of use, …

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An Exploration Of The Influences Of Race, Class And Gender Identity On The Help-Seeking Behavior Of Lgbtq Survivors Of Violence, Xavier Guadalupe Apr 2010

An Exploration Of The Influences Of Race, Class And Gender Identity On The Help-Seeking Behavior Of Lgbtq Survivors Of Violence, Xavier Guadalupe

Theses and Dissertations

Without a doubt, violence continues to be a brutal reality in our society. It reaches and affects millions across our nation and around the world. For centuries, scholars, researchers and academics have studied and analyzed the existence of violence in many capacities. While violence affects every individual, group, and community the dynamics and the realties that are carried out vary tremendously across race, income levels, gender, gender identity and expression, sexual orientation and national origin to name a few. The existence, impact and repercussions of violence in different communities carry varying meanings, perceptions and significance. This paper explores the influences …

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Small Molecule Inhibitors Of Mapk And Pi3k Pathways Enhance Mda-7 Lethality In Renal Cell Carcinoma, Patrick Eulitt Apr 2010

Small Molecule Inhibitors Of Mapk And Pi3k Pathways Enhance Mda-7 Lethality In Renal Cell Carcinoma, Patrick Eulitt

Theses and Dissertations

Renal cell carcinoma accounted for an estimated 57,760 new cases and estimated 12,980 deaths in the United States in 2009. Current treatment options for systemic renal cell carcinoma yield markedly low response percentages; however, recent cytokine therapy experiments have produced promising results. A novel adenovirus, Ad.5/3-mda-7, has been synthesized to efficiently infect renal cancer cells with the mda-7 gene. This gene encodes for the cytokine MDA-7/IL-24 that has the ability to specifically target transformed cells. Assays performed with this adenovirus resulted in an increased percentage of cell death in renal cancer cells when compared to infection with Ad.5/3-cmv empty vector. …

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Differentiating Reading Instruction For Special Education Students In An Inclusive Middle School: Comparing Teacher Knowledge And Application, Lauran Ziegler Apr 2010

Differentiating Reading Instruction For Special Education Students In An Inclusive Middle School: Comparing Teacher Knowledge And Application, Lauran Ziegler

Theses and Dissertations

DIFFERENTIATING READING INSTRUCTION FOR SPECIAL EDUCATION STUDENTS IN AN INCLUSIVE MIDDLE SCHOOL: COMPARING TEACHER KNOWLEDGE AND APPLICATION This qualitative case study uses observations and interviews to examine the practice of differentiation by twelve collaborative middle school reading teachers in a school that has shown a decrease in the achievement gap for students with disabilities on end of year tests on state standards. Observations and interviews were analyzed to determine the teachers’ knowledge and application of differentiated instruction. The results showed that four of the six teams possessed a comprehensive knowledge of the practice of differentiation and the data available to …

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Implication Of Gender Stereotypes For Public Policy, Sharon Smith Apr 2010

Implication Of Gender Stereotypes For Public Policy, Sharon Smith

Theses and Dissertations

Stereotypes continue to be present and impact the assessment of women’s leadership effectiveness. Using a data set of senior executives in the public sector from The Leadership Circle multi-rater assessment tool, research supports the theory that gender influences how bosses rate their direct reports on leadership effectiveness. Survey data identifying leadership characteristics in the assessment as communal or agentic substantiate role congruence theory that women are still penalized for behaving contrary to the feminine stereotype. Role congruence theory seeks to explain the barriers that prevent women from rising into leadership positions. Representative bureaucracy explains the consequence in public policy when …

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Commonwealth Times 2010-04-19 [Front Page Has 2010-04-15] Apr 2010

Commonwealth Times 2010-04-19 [Front Page Has 2010-04-15]

Commonwealth Times, 1969-

No abstract provided.

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Museums In The Classroom: Preservation Virginia’S John Marshall House Trunk, Denisse Marie De Leon Apr 2010

Museums In The Classroom: Preservation Virginia’S John Marshall House Trunk, Denisse Marie De Leon

Theses and Dissertations

Since the No Child Left Behind Act (NCLB) was passed in 2001, museum educators have faced new challenges in designing programming that incorporates state standards of education while remaining faithful to the integrity of the museum’s collection and mission. Some museums have created programs that address these educational standards and can be used in school classrooms. This project is a case study of how one Virginia museum, Preservation Virginia, created a classroom program that addresses the state mandated Standards of Learning (SOLs). The report of this project includes discussion of the current debates that surround NCLB and its relationship to …

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Proteasome-Dependent Entry Of Herpes Simplex Virus, Mark Delboy Apr 2010

Proteasome-Dependent Entry Of Herpes Simplex Virus, Mark Delboy

Theses and Dissertations

Herpes simplex virus entry into cells is a multistep process that engages the host cell machinery. The proteasome is a large, ATP-dependent, multisubunit protease that plays a critical role in the maintenance of cell homeostasis. A battery of assays were used to demonstrate that proteasome inhibitors blocked an early step in herpes simplex virus entry that occurred after capsid penetration into the cytosol but prior to capsid arrival at the nuclear periphery. Proteasome-dependent viral entry was not reliant on host or viral protein synthesis. MG132, a peptide aldehyde that competitively inhibits the degradative activity of the proteasome, had a reversible …

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Sensitivity Analysis – The Effects Of Glasgow Outcome Scale Misclassification On Traumatic Brain Injury Clinical Trials, Juan Lu Apr 2010

Sensitivity Analysis – The Effects Of Glasgow Outcome Scale Misclassification On Traumatic Brain Injury Clinical Trials, Juan Lu

Theses and Dissertations

I. EFFECTS OF GLASGOW OUTCOME SCALE MISCLASSIFICATION ON TRAUMATIC BRAIN INJURY CLINICAL TRIALS The Glasgow Outcome Scale (GOS) is the primary endpoint for efficacy analysis of clinical trials in traumatic brain injury (TBI). Accurate and consistent assessment of outcome after TBI is essential to the evaluation of treatment results, particularly in the context of multicenter studies and trials. The inconsistent measurement or interobserver variation on GOS outcome, or for that matter, on any outcome scales, may adversely affect the sensitivity to detect treatment effects in clinical trial. The objective of this study is to examine effects of nondifferential misclassification of …

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From The Old To The New World: The Transformation Of Kongo Minkisi In African American Art, Mary Mccurnin Apr 2010

From The Old To The New World: The Transformation Of Kongo Minkisi In African American Art, Mary Mccurnin

Theses and Dissertations

Minkisi (sing. nkisi) were sacred objects that housed ancestral spirits and were used for divination, healing and social justice by the Kongo people of Central Africa. When the Kongo were brought as slaves to the New World, they contributed significantly to the development of African American artistic and spiritual culture. In the Caribbean, aspects of minkisi have been retained in the creolized spiritual beliefs of Haitian Vodou, Cuban Palo Monte Mayombe and Brazilian Candomble. In North America, evidence of Kongo influence is apparent in examples of folk art and culture, including quilts, mojo hands, Afro-Carolinian face vessels, memory jugs and …

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The Influence Of Organizational Culture On The Existence Of Systems Employed To Improve Quality Of Care In Medical Office Practices, Donna Dugan Apr 2010

The Influence Of Organizational Culture On The Existence Of Systems Employed To Improve Quality Of Care In Medical Office Practices, Donna Dugan

Theses and Dissertations

A frequently cited reason for poor quality of care in the ambulatory care setting is the lack of optimally designed systems to address care for those with preventive or chronic care needs. Organizational theory suggests that culture plays an important role in the shaping of these types of programs. The purpose of this cross-sectional study is to understand through descriptive and regression analysis of secondary data, the relationship between the existence of cultural characteristics such as collegiality, quality emphasis and autonomy, and the systems employed to improve quality of care within primary care practices. The study uses an integrated theoretical …

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More Than A Prayer: Pastors' Perception And Practice Of Mental Health Services, Jessica Young Apr 2010

More Than A Prayer: Pastors' Perception And Practice Of Mental Health Services, Jessica Young

Theses and Dissertations

While African Americans show similar rates of mental health concerns, they seek and obtain significantly fewer traditional mental health services (MHS) as compared to other groups. One alternative to traditional forms of MHS is the use of church-based resources, such as pastoral counseling. Pastors frequently report counseling as a large part of their duties. Therefore, their perceptions about mental health have a major impact on services that parishioners receive. This online survey assessed 40 pastors' perceptions about mental health services, as well as perceived needs for information or training. Attitudes about mental health were significantly related to variety of counseling …

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Commonwealth Times 2010-04-15 Apr 2010

Commonwealth Times 2010-04-15

Commonwealth Times, 1969-

No abstract provided.

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Afro-German Biracial Identity Development, Rebecca R. Hubbard Apr 2010

Afro-German Biracial Identity Development, Rebecca R. Hubbard

Theses and Dissertations

An increase in the biracial population has heightened our awareness of unique issues that pervade the experience of these individuals. The importance of environmental influences on biracial identity development has been established, but investigations concerning racial socialization of biracial individuals are scarce. This study, utilizing a qualitative design, explores racial identity development of biracial Afro-Germans living in Germany. The purpose of the study is to understand the strategies that biracial individuals use to negotiate their racial identity, factors that influence their development, cultural influences, and racial socialization processes. Interviews with biracial Afro-Germans were conducted using phenomenological interviewing techniques. Twelve themes …

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Modulation Of Cocaine-Like Behavioural Activity By Serotonin Uptake Inhibition Relative To The Effects Of The Novel And Selective Dopamine Transporter Inhibitor, D-84, Angela Batman Apr 2010

Modulation Of Cocaine-Like Behavioural Activity By Serotonin Uptake Inhibition Relative To The Effects Of The Novel And Selective Dopamine Transporter Inhibitor, D-84, Angela Batman

Theses and Dissertations

Cocaine dependence is a major health concern worldwide, but despite this high rate of abuse there are currently no approved therapies for cocaine dependence. Replacement pharmacotherapies are one possible approach for treating cocaine dependence, and identification of such therapeutics for cocaine abuse is the long-term goal of this research. Cocaine binds to, and inhibits uptake at the dopamine (DAT), serotonergic (SERT) and noradrenaline (NET) uptake transporters, but studies have shown that cocaine produces its strong behavioural and positive reinforcing effects through inhibition of the DAT. To this end a great number of diverse, non-selective DAT-inhibiting compounds have been investigated as …

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Forgiveness And The Bottle: Promoting Self-Forgiveness With Alcohol Misuse, Michael Scherer Apr 2010

Forgiveness And The Bottle: Promoting Self-Forgiveness With Alcohol Misuse, Michael Scherer

Theses and Dissertations

Forgiveness research has seldom been directed toward alcohol use, misuse, and abuse. To date, forgiveness research in the realm of alcohol use, misuse, and abuse has focused on interpersonal consequences (e.g., Lin, Mack, Enright, Krahn, & Baskin, 2005; Scherer, Worthington, Hook, Campana, West, & Gartner, 2009; Worthington, Scherer, & Cooke, 2006), but has paid minimal attention to intrapersonal consequences. Psychologists today are just beginning to explore the complex and murky waters of self-forgiveness (or lack of it) and the alcohol misuser (e.g., Webb, Robinson, Brower, & Zucker, 2006). In the current dissertation, I review the literature on self-forgiveness, drinking refusal …

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The Clinical Utility Of Molecular Typing Of Multiply-Resistant Pseudomonas Aeruginosa In Children With Cystic Fibrosis, Ruth Ann Luna Apr 2010

The Clinical Utility Of Molecular Typing Of Multiply-Resistant Pseudomonas Aeruginosa In Children With Cystic Fibrosis, Ruth Ann Luna

Theses and Dissertations

Chronic infection with P. aeruginosa is expected in patients with cystic fibrosis (CF), but the ability to delay, prevent, or better manage infection with multiply-resistant P. aeruginosa (MRPA) can potentially increase quality of life and extend survival. The Texas Children’s Hospital CF Care Center has identified an endemic MRPA strain (dominant clone), and this study aimed to identify risk factors for acquisition of the clone as well as determine differences in patient outcome associated with subsequent infection with the clone. The study included 71 patients with CF with documented MRPA infection. Designation of patients as members of the dominant clone …

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Commonwealth Times 2010-04-08 Apr 2010

Commonwealth Times 2010-04-08

Commonwealth Times, 1969-

No abstract provided.

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Perifosine, A Novel Akt Inhibitor Induces Apoptosis, Cell Cycle Arrest And Has A Chemo-Sensitizing Effect In Medulloblastoma Cell Lines, Anil Kumar Apr 2010

Perifosine, A Novel Akt Inhibitor Induces Apoptosis, Cell Cycle Arrest And Has A Chemo-Sensitizing Effect In Medulloblastoma Cell Lines, Anil Kumar

Theses and Dissertations

Primary central nervous system (CNS) tumors are the most common solid tumors found in children. While surgery and radiotherapy still remain the standard treatment modalities in pediatric brain tumors, chemotherapy also has an important part in the management of these tumors. However, most of the available chemotherapeutic drugs have suboptimal effectiveness. Deregulation of various pro-apoptotic and anti-apoptotic pathways has been cited as a major mechanism underlying this drug resistance. The role of various serine threonine kinases, including Akt kinases, in promoting drug resistance is being extensively studied in various cancers. A complete understanding of the molecular mechanisms that underlie drug …

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Differences In Peer Perception Of Alcohol Use, Personal Alcohol Use, And Levels Of Intoxication Among Students At Virginia Commonwealth University From 2002 To 2004., William Evans Apr 2010

Differences In Peer Perception Of Alcohol Use, Personal Alcohol Use, And Levels Of Intoxication Among Students At Virginia Commonwealth University From 2002 To 2004., William Evans

Theses and Dissertations

This study involves the examination of National Collegiate Health Assessment (NCHA) data collected by the VCU Wellness Resource Center. This study will compare trends in college student health behavior perceptions and personal activity regarding alcohol use, as self-reported via the NCHA data, with a particular focus on a comparison between 2002, which is the year that the Wellness Resource Center (then known as the Office of Health Promotion) first implemented an alcohol education campaign based upon a “social norms” theoretical framework, and 2004, after 18 months of intensive campaigning. Thus, the aim of the project is to examine the changes …

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Segmentation And Fracture Detection In X-Ray Images For Traumatic Pelvic Injury, Rebecca Smith Apr 2010

Segmentation And Fracture Detection In X-Ray Images For Traumatic Pelvic Injury, Rebecca Smith

Theses and Dissertations

Due to the risk of complications such as hemorrhage, severe pelvic trauma is associated with a high mortality rate. Prompt medical treatment is therefore vital. However, the complexity of the injuries can make successful diagnosis and treatment challenging. By generating predictions and recommendations based on patient data, computer-aided decision support systems have the potential to assist physicians in improving outcomes. However, no current system considers features automatically extracted from medical images. This dissertation describes a system to extract diagnostic features from pelvic X-ray images that can be used as input to the prediction process; specifically, the presence of fracture and …

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