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Family Preservation In Families’ Ecological Systems: Factors That Predict Out-Of-Home Placement And Maltreatment For Service Recipients In Richmond City, Jody Hearn Apr 2010

Family Preservation In Families’ Ecological Systems: Factors That Predict Out-Of-Home Placement And Maltreatment For Service Recipients In Richmond City, Jody Hearn

Theses and Dissertations

Family preservation services are intended to prevent the out-of-home placement (into foster care or some other alternative arrangement) of children and youth in families at risk of maltreating them. An Ecological Systems perspective of these families might suggest that a family’s context (represented by the variables of poverty, agency services, family history, and individual/caretaker characteristics) must be considered as an over-arching influence in families’ risk and outcomes. The purpose of this cross-sectional secondary data analysis study was to identify layered factors that distinguish family preservation cases in Richmond, VA that experience removal or subsequent abuse or neglect from those that …

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Development And Implementation Of A Tissue Specific Microrna Prediction Tool For Identifying Targets Of The Tumor Suppressor Microrna 17-3p, William Budd Apr 2010

Development And Implementation Of A Tissue Specific Microrna Prediction Tool For Identifying Targets Of The Tumor Suppressor Microrna 17-3p, William Budd

Theses and Dissertations

A unique computational approach was undertaken to identify targets of miR-17-3p that impart an oncogenic potential to the cells of the prostate. Utilizing this approach, we identified insulin growth factor receptor 1 (IGF1R) as a potential target of miR-17-3p. IGF1R imparts an oncogenic approach to the cells by helping cells escape apoptosis, become hypertrophic and increase the production of extracellular proteases that allow cells to detach from neighbors. The regulation of insulin growth factor receptor 1 by human microRNA-17-3p was evaluated using a western blot analysis of prostate cancer cell lines. Protein levels were compared in a cell line that …

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Tied Together: A Molecular Role For Tie1 In Angiopoietin Tie2 Signaling, Tom Cm Seegar Apr 2010

Tied Together: A Molecular Role For Tie1 In Angiopoietin Tie2 Signaling, Tom Cm Seegar

Theses and Dissertations

The primary function of the vascular system is the maintenance of oxygen homeostasis for all metazoan tissue. Angiogenesis, the remodeling and maintenance of new blood vessels from an existing vessel, is primarily controlled through the endothelial specific receptor tyrosine kinase Tie2, and the orphan receptor tyrosine kinase, Tie1. Although these receptors share highly conserved, genetic and biochemical analysis has shown these receptors have distinct and essential roles in angiogenesis. Tie2 activation typically results in vessel stability and quiescences and has further been shown to interact with all four sub-types of the angiopoietin signaling factors, Ang1-4. Conversely, Tie1 is involved in …

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[2010-04-29] Meeting Of The Academic And Health Affairs Policy Committee, Virginia Commonwealth University. Board Of Visitors Apr 2010

[2010-04-29] Meeting Of The Academic And Health Affairs Policy Committee, Virginia Commonwealth University. Board Of Visitors

VCU Board of Visitors Minutes

Official minutes of the VCU Board of Visitors and its Executive Committee.

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The Mechanism Of Mitochondrial Folate Transport By The Mitochondrial Folate Transporter, Scott Alan Lawrence Apr 2010

The Mechanism Of Mitochondrial Folate Transport By The Mitochondrial Folate Transporter, Scott Alan Lawrence

Theses and Dissertations

The mitochondrial folate transport protein (MFT) functions to transport folates into the mitochondrial matrix. The MFT is a member of a mitochondrial carrier family (MCF) of proteins that have a high degree of sequence and structural similarities, yet they transport vastly different substrates at high specificities. In this dissertation research, the folate-specific transport mechanism of the MFT was explored using experimental and computational techniques. MFT residues that differed from MCF consensus residues in conserved PxD/ExxK/R motifs and at a predicted substrate-binding site common to all MCF proteins were investigated. Site-directed mutagenesis of these anomalous residues in the MFT revealed that …

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Voice On The Skin, Sarah Turner Apr 2010

Voice On The Skin, Sarah Turner

Theses and Dissertations

“The body can write on the skin from the inside—the soul, the mind, and the passions rise to the surface in boils, blushes, and rashes, and the invisible inside speaks by writing from the other side of the page”. -James Elkins Skin not only covers but reveals what is behind it. I utilize its language as indicator of flaws and pathologies. I depict and manipulate this, not just as it already exists with the human body, but as projections of my psychological states onto inanimate objects. Proposing that sight is a kind of touch, we touch with our minds, through …

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An Investigation Of The Effects Of Class Size On Student Achievement In Title I Elementary Schools: A Mixed Methods Study, Jennifer Murphy Apr 2010

An Investigation Of The Effects Of Class Size On Student Achievement In Title I Elementary Schools: A Mixed Methods Study, Jennifer Murphy

Theses and Dissertations

This was a multi-faceted mixed methods study that investigated several aspects associated to class size and the perceived effects on student achievement in Title I elementary schools. The data collection in this study was conducted through two separate phases. The first qualitative phase was a case study that was comprised of teacher interviews and classroom observations. The case study took place at a Title I school in Central Virginia, chosen for its diverse representativeness of the student population. Classroom interactions were coded during five-minute segments in each full-day classroom observation, as well as field notes made for specific types of …

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Insulin-Like Growth Factor Binding Protein-3 (Igfbp-3) Plays An Essential Role In Cellular Senescence: Molecular And Clinical Implications., Amanda Garza Apr 2010

Insulin-Like Growth Factor Binding Protein-3 (Igfbp-3) Plays An Essential Role In Cellular Senescence: Molecular And Clinical Implications., Amanda Garza

Theses and Dissertations

Normal somatic cells have a limited proliferative capacity in vivo and in vitro, termed senescence and later, thought to contribute to molecular and cellular organismal aging. There are several studies that demonstrate the importance of the GH/IGF axis in longevity, aging and cellular senescence. One primary component of the IGF signaling involves IGFBP-3. It is well documented that IGFBP-3 levels are significantly increased in senescent human diploid fibroblasts however IGFBP-3 function is not known in this system. Interestingly, Werner syndrome fibroblasts, commonly used as a model of cellular aging, have upregulated IGFBP-3 levels in young and late passage cells compared …

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Expression & Purification Of Recombinant Plasmodium Falciparum Erythrocyte-Binding Ligands, Seward Joann Cofie Apr 2010

Expression & Purification Of Recombinant Plasmodium Falciparum Erythrocyte-Binding Ligands, Seward Joann Cofie

Theses and Dissertations

Plasmodium falciparum, the most virulent malarial parasite, is capable of invading all known human blood types. Erythrocyte invasion depends on specific parasite ligand and erythrocyte receptor interactions. These interactions are mediated by Region II of the P. falciparum erythrocyte binding ligands. Although invasion does not seem dependent upon a singular ligand, their individual contributions to the invasion process are yet to be explained. In this study, Region II of P. falciparum binding ligands BAEBL and JESEBL were transiently expressed as hexahistidyl recombinant proteins in COS-1 cells. Purification by column chromatography yielded 0.52 mg of BAEBL and 0.433 mg of JESEBL. …

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The Roles Of Religious Coping, World Assumptions, And Personal Growth In College Student Bereavement, Benjamin Lord Apr 2010

The Roles Of Religious Coping, World Assumptions, And Personal Growth In College Student Bereavement, Benjamin Lord

Theses and Dissertations

The field of bereavement research is currently lacking empirical studies examining grief in adolescent and young adult populations. Furthermore, the roles of religion (Hays, & Hendrix, 2008), meaning-making (Park, 2005) and post-bereavement personal growth (Davis, 2008), all of which are critical to understanding the loss experiences of people in these age groups (Balk, & Corr, 1996), have yet to be enumerated in a reliable way in the literature. Stroebe (2004) has emphasized the need to improve methods and measurement tools by including more thorough measures of religious coping and bereavement experience. The current study aimed to clarify the process of …

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The Middle School Transition In Private Schools: Student Perceptions, Eileen Atkinson Apr 2010

The Middle School Transition In Private Schools: Student Perceptions, Eileen Atkinson

Theses and Dissertations

Abstract THE MIDDLE SCHOOL TRANSITION IN PRIVATE SCHOOLS: STUDENT PERCEPTIONS By Eileen Irby Atkinson, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2010 Director: Cheryl Magill, Ph.D., Assistant Professor, Department of Educational Leadership Students transitioning into the middle school often experience difficulty adjusting to their new environment. During this transition, declines in academic motivation, academic achievement, and connectedness have been noted. Most research on this transition has taken place in public school settings. This research investigated the impact of the middle school transition in …

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A Survey Of The Usage Of Topical Anesthesia Among Dentist, Lawrence Shults Apr 2010

A Survey Of The Usage Of Topical Anesthesia Among Dentist, Lawrence Shults

Theses and Dissertations

Purpose: The purposes of this study were four-fold: 1) to determine the types and effectiveness of various topical anesthetics being used among dentists currently treating children, 2) to determine the types of procedures for which topical anesthetics are being used among children, 3) to understand the awareness and use of a relatively newer compounded topical gel Oraqix (Dentsply Caulk) among children, 4) to understand the adverse reactions to topical anesthesia that are seen among children. Methods: A cross sectional survey was designed, regarding the type, procedural use, effectiveness, and adverse reactions noted among children to various topical anesthetics. The survey …

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Oral Health Status Of Children In The Child Health Investment Partnership (Chip) Program, Latrice Foster Apr 2010

Oral Health Status Of Children In The Child Health Investment Partnership (Chip) Program, Latrice Foster

Theses and Dissertations

Purpose: The purpose of this study is to describe children’s dental disease status and functional health literacy of families enrolled in the Child Health Investment Partnership program in Roanoke Valley. Methods: This was a prospective cohort study of children (n=166) enrolled in the Child Health Investment Partnership of Roanoke Valley, Virginia (CHIP). The parents of the 166 children completed the Life Skills Progression (LSP) survey at enrollment between September 2004 and September 2008 to assess their functional health literacy levels. Their LSP scores were used to determine their subsequent health care literacy (HCL), personal health literacy (PHL), and dental-child utilization …

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The Relationship Between The Use Of Academic Accommodations And Successful Program Completion Of Students With Disabilties At Community Colleges, Mark Richardson Apr 2010

The Relationship Between The Use Of Academic Accommodations And Successful Program Completion Of Students With Disabilties At Community Colleges, Mark Richardson

Theses and Dissertations

The purpose of this study was to examine the relationship between the use of academic accommodations and successful program completion of students with disabilities enrolled in two campuses of a community college. Current and past research has focused on the role, faculty perception and student satisfaction of Disability Support Services (DSS) at postsecondary institutions. However, evidence that the use of academic accommodations actually aids in the successful program completion rate of post secondary students with disabilities does not exist. A causal-comparative research method was used to examine secondary data provided by the Office of Student Accommodations located at two community …

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Mechanisms Associated With Aging And Age-Related Disease In Drosophila, Melanie Jones Apr 2010

Mechanisms Associated With Aging And Age-Related Disease In Drosophila, Melanie Jones

Theses and Dissertations

Aging is an intrinsic process that is independent of obvious disease. In contrast to normal aging, age-related diseases are conditions that typically manifest at advanced ages, are associated with explicit pathology and cause disability and premature death. We used Drosophila as a model to investigate the molecular-genetic mechanisms associated with aging and age-related disease. Age-related locomotor impairment (ARLI) is a serious condition for the elderly and greatly impacts their quality of life. Toward identifying genes and mechanisms that influence ARLI, we performed a forward genetic screen using Drosophila mutants. This screen identified a loss of function mutant in PDK1, a …

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Focal Adhesion Kinase, A Major Regulator Of Oligodendrocyte Morphological Maturation And Myelination, Audrey Lafrenaye Apr 2010

Focal Adhesion Kinase, A Major Regulator Of Oligodendrocyte Morphological Maturation And Myelination, Audrey Lafrenaye

Theses and Dissertations

The formation of the myelin sheath is a crucial step during development because it enables fast and efficient propagation of signals within the limited space of the mammalian central nervous system. During the process of myelination, oligodendrocytes actively interact with the extracellular matrix (ECM). These interactions are considered crucial for proper and timely completion of the myelin sheath. However, the exact regulatory circuits involved in the signaling events that occur between the ECM and oligodendrocytes are currently not fully understood. Therefore, in this dissertation we investigated the role of a known integrator of cell-ECM signaling, namely, focal adhesion kinase (FAK), …

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Exploring The Mechanism Of Alginate Acetylation In Pseudomonas Aeruginosa, Janice Paletta Apr 2010

Exploring The Mechanism Of Alginate Acetylation In Pseudomonas Aeruginosa, Janice Paletta

Theses and Dissertations

The opportunistic pathogen P. aeruginosa is the leading cause of morbidity and mortality in cystic fibrosis patients. During chronic infection of the cystic fibrosis lung, P. aeruginosa undergoes conversion to a mucoid phenotype, constitutively producing the exopolysaccharide alginate, composed of the uronic acids D-mannuronate and L-guluronate. This alginate production contributes significantly to virulence in the cystic fibrosis lung. Evidence suggests that the acetylation state of the mannuronate component of the alginate influences the ability of components of the immune system to phagocytose the organism. To garner new and relevant information regarding the mechanism of alginate acetylation in Pseudomonas aeruginosa, a …

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Patterns In Fish Community Structure In A Regulated River, Richard Davis Apr 2010

Patterns In Fish Community Structure In A Regulated River, Richard Davis

Theses and Dissertations

I examined the abundance, composition, and distribution of fish communities in the lower Roanoke River, a hydropeaking system in North Carolina. Fishes were sampled at before and after peaking events over three years; 2007 to 2009. I evaluated trends in species richness, diversity, and assemblage composition. There were no significant differences in either richness or diversity suggesting consistent trends in richness and diversity throughout the study. I used non-metric multidimensional scaling (NMDS) to create a community composition model. Fish composition was noticeably greater post-peaking and changed minimally across time and event. There were no statistically significant differences in species composition …

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Understanding Posttraumatic Growth Among Individuals With Cancer: The Role Of Social Support And Unsupportive Interactions, Wendy Balliet Apr 2010

Understanding Posttraumatic Growth Among Individuals With Cancer: The Role Of Social Support And Unsupportive Interactions, Wendy Balliet

Theses and Dissertations

The experience of being diagnosed with and treated for cancer is an extremely stressful experience for most individuals. Historically, the literature on stress and coping has focused on negative outcomes, such as depression and anxiety, in relation to one‘s experience with cancer. Under-represented in the literature has been a theoretical framework that examines positive and transformative experiences that may occur throughout the cancer experience. The current study assessed interpersonal variables that rarely have been investigated in relation to one‘s experience with cancer (i.e., received social support and unsupportive interactions) and their association with depressive symptoms, positive emotion, and posttraumatic growth …

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An Affordable Living Community, Erin Richardson Apr 2010

An Affordable Living Community, Erin Richardson

Theses and Dissertations

Beginning with a former grocery store building, “An Affordable Living Community,” explores the possibilities of redesigning big box buildings. Here, the building is transformed into an affordable living community - a place for people to live, work, learn, and interact. The renovation creates a place for not only its residents, but also the surrounding neighborhoods. The building provides the challenges of breaking the generic, window-less facade, as well as bringing light into the building. This model would encourage the health, learning, and support of its community.

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Seasonal Patterns Of Nutrient Retention In A Restored Tidal Freshwater Stream Of The Mid-Atlantic Coastal Plain, Joseph Wood Apr 2010

Seasonal Patterns Of Nutrient Retention In A Restored Tidal Freshwater Stream Of The Mid-Atlantic Coastal Plain, Joseph Wood

Theses and Dissertations

Nutrient retention is governed by the interplay between physical processes that control the throughput of water and materials (i.e., water residence time), and by biological processes that govern transformation and uptake (e.g., microbial denitrification). A partial breach of the dam located on Kimages Creek (VA) re-established the historical (pre-1920) connection to the James River and provided a well-defined channel to gauge tidal exchange. We quantified tidal exchange as well as non-tidal (watershed) inputs on a monthly basis to assess Nitrogen (N) retention. Water and N fluxes were dominated by tidal exchange which was typically three times greater than inputs from …

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Identification Of Loci Contributing To The Smith-Magenis Syndrome-Like Phenotype And Molecular Evaluation Of The Retinoic Acid Induced 1 Gene, Stephen Williams Apr 2010

Identification Of Loci Contributing To The Smith-Magenis Syndrome-Like Phenotype And Molecular Evaluation Of The Retinoic Acid Induced 1 Gene, Stephen Williams

Theses and Dissertations

Smith-Magenis syndrome (SMS) is a multiple congenital abnormalities intellectual disability syndrome that results from a deletion of chromosome 17p11.2 or mutation of the retinoic acid inducted one gene (RAI1). SMS is characterized by a multitude of phenotypic features including craniofacial defects, short stature, obesity, intellectual disability, self-abusive behavior, sleep disturbance and behavioral abnormalities. Interestingly, although SMS is a clearly defined syndrome with a known molecular change at its foundation, ~40% of all candidate cases sent to the Elsea lab for evaluation do not have a mutation or deletion of RAI1. We hypothesize that at least one other locus must be …

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Commonwealth Times 2010-04-26 Apr 2010

Commonwealth Times 2010-04-26

Commonwealth Times, 1969-

No abstract provided.

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Job And Personal Resources And Demands: The Effects On Job Satisfaction And Job Search Behavior Of Certified Nursing Assistants (Cnas) Working In Nursing Homes, Natsuko Ryosho Apr 2010

Job And Personal Resources And Demands: The Effects On Job Satisfaction And Job Search Behavior Of Certified Nursing Assistants (Cnas) Working In Nursing Homes, Natsuko Ryosho

Theses and Dissertations

The purpose of the current study was to examine how job resources, job demands, personal resource, personal demands, and demographic characteristics predict job satisfaction and job search behavior of certified nursing assistants (CNAs) working in nursing homes. The study used data from the 2004 National Nursing Assistant Survey (NNAS). The job demands-resources (JD-R) model (Demerouti, Bakker, Nachreiner, & Schaufeli, 2001) provided the basis for the conceptual framework of the study. First, a series of multinomial logistic regression analyses were performed to determine how the five categories of predictor variables predicted the levels of job satisfaction among CNAs. Next, a series …

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The Audsleys, The Blackies And The Practical Decorator And Ornamentist, Gay Acompañado Apr 2010

The Audsleys, The Blackies And The Practical Decorator And Ornamentist, Gay Acompañado

Theses and Dissertations

The Practical Decorator and Ornamentist (Glasgow, 1892), one of the jewels in James Branch Cabell Library, embodies the work of the distinguished British designers George Ashdown Audsley and Maurice A. Audsley; the eminent Scottish publishing firm of Blackie & Son; and the illustrious French printing house of Didot. The thesis argues that the Decorator is one of the great nineteenth-century design books. Chapter one focuses on G. A. Audsley’s five masterworks and illustrates the contributions of a distinguished family of architects. There has not been a study of the Audsleys in ten years, and the present study goes further than …

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Movement Without Motion: The Rhetoric Of Conservative Counter-Claims To Global Warming Theory, William Edwards Apr 2010

Movement Without Motion: The Rhetoric Of Conservative Counter-Claims To Global Warming Theory, William Edwards

Theses and Dissertations

Many U.S. conservatives view government mandates to reduce emissions of greenhouse gases as a threat to the economy of the developed world. Conservative think tanks have adopted a common rhetoric to instill doubt about proposed mandates in the minds of elected officials, the media, and the public. Using a survey of the websites of 14 conservative think tanks, this thesis analyzes counter-claims to global warming theory to identify rhetorical artifacts that typically characterize conservative responses to issues, and to show how rhetorical theory can help anticipate the nature of such responses. The research identifies unifying speech codes – such as …

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Image Segmentation And Analysis For Automated Classification Of Traumatic Pelvic Injuries, Simina Vasilache Apr 2010

Image Segmentation And Analysis For Automated Classification Of Traumatic Pelvic Injuries, Simina Vasilache

Theses and Dissertations

In the past decades, technical advances have allowed for the collection and storage of more types and larger quantities of medical data. The increase in the volume of existing medical data has increased the need for processing and analyzing such data. Medical data holds information that is invaluable for diagnostic as well as treatment planning purposes. Presently, a large portion of the data is not optimally used towards medical decisions because information contained in the data is inaccessible through simple human inspection, or traditional computational methods. In the field of trauma medicine, where caregivers are frequently confronted with situations where …

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Characterization Of Adherence, Cytotoxicity And Biofilm Formation By Gardnerella Vaginalis, Jennifer Patterson Apr 2010

Characterization Of Adherence, Cytotoxicity And Biofilm Formation By Gardnerella Vaginalis, Jennifer Patterson

Theses and Dissertations

Worldwide, bacterial vaginosis (BV) is the most common vaginal disorder in women of childbearing age. BV is of major clinical importance due to its ability to significantly affect pregnancy outcome and enhance the transmission and acquisition of HIV. BV is characterized by a dramatic shift in the vaginal microflora; in most BV cases, the predominant bacterial species is Gardnerella vaginalis. It has been demonstrated that G. vaginalis forms an adherent biofilm on the vaginal epithelium of women with BV. Furthemore, evidence suggests that the high rate of recurrence associated with BV is related to incomplete eradication of the biofilm. The …

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Fundamental Work Toward An Image Processing-Empowered Dental Intelligent Educational System, Grace Olsen Apr 2010

Fundamental Work Toward An Image Processing-Empowered Dental Intelligent Educational System, Grace Olsen

Theses and Dissertations

Computer-aided education in dental schools is greatly needed in order to reduce the need for human instructors to provide guidance and feedback as students practice dental procedures. A portable computer-aided educational system with advanced digital image processing capabilities would be less expensive than current computer-aided dental educational systems and would also address some of their limitations. This dissertation outlines the development of novel components that would be part of such a system. This research includes the design of a novel image processing technique, the Directed Active Shape Model algorithm, which is used to locate the tooth and drilled preparation from …

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The Effect Of Power On Exploratory Behavior, William Clay Apr 2010

The Effect Of Power On Exploratory Behavior, William Clay

Theses and Dissertations

The relations between power, exploratory behavior, and willingness to take risks were investigated. It was hypothesized that high power would be associated with increases in exploratory behavior, and that this relationship would be mediated by participants’ willingness to take risks. In Study One, one-hundred forty-one undergraduates (66% female) completed questionnaires to assess trait power and willingness to take risk, as well as a computer-based research paradigm, BeanFest, to assess exploration. Willingness to take risks correlated positively with exploration. However, the predicted relations involving power were not observed. In Study Two, power was experimentally manipulated. One-hundred thirty-three undergraduates (61% female) were …

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