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Phytoremediation Of Pcb Contaminated Soil: Effectiveness And Regulatory Policy, Nathan Pinsker Apr 2011

Phytoremediation Of Pcb Contaminated Soil: Effectiveness And Regulatory Policy, Nathan Pinsker

Theses and Dissertations

The purpose of this paper was to combine available peer-reviewed literature on PCB phytoremediation and make direct comparisons using ANCOVA statistics in order to determine if and what plants are presently a viable option for the remediation of PCB contaminated soils. Pumpkin (Curbita pepo cv Howden) consistently had the top root and shoot concentrations, as well as total plant accumulation. Their consistency shows that they can be reliable in the field and the most viable option. Tall fescue and sedge were also top contenders. Due to the small sample size for many plants and accounting for several confounding variables, very …

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Commonwealth Times 2011-04-28 Apr 2011

Commonwealth Times 2011-04-28

Commonwealth Times, 1969-

No abstract provided.

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Sulfatide Is Required For Organization Of The Paranode In The Myelinated Axon In The Peripheral Nervous System, Eva Kwong Apr 2011

Sulfatide Is Required For Organization Of The Paranode In The Myelinated Axon In The Peripheral Nervous System, Eva Kwong

Theses and Dissertations

Myelin facilitates the timely, efficient conduction of action potentials along axons. Made by Schwann cells (SCs) in the PNS, myelin is unique in that it is composed of a high percentage of lipids, particularly galactolipids. Sulfatide, one such galactolipid, is made by cerebroside sulfotransferase (CST) and has been shown to play a role in organizing paranodal domains in myelinated axons. However less is known regarding the involvement of sulfatide in the establishment and maintenance of the node, of particular interest as it is responsible for the potentiation of action potentials along the axon. Using immunohistochemical and, to a lesser extent, …

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Distinct T Cell Clones Are Associated With Graft-Versus-Host Disease (Gvhd), And Potentially Graft-Versus-Tumor (Gvt), Responses Following Allogeneic Stem Cell Transplantation, Jennifer Berrie Apr 2011

Distinct T Cell Clones Are Associated With Graft-Versus-Host Disease (Gvhd), And Potentially Graft-Versus-Tumor (Gvt), Responses Following Allogeneic Stem Cell Transplantation, Jennifer Berrie

Theses and Dissertations

In patients undergoing hematopoietic stem cell transplantation (HSCT) with HLA-identical donors, genetic polymorphisms result in a mismatch between donors and recipients in their minor histocompatibility antigens (mHAgs), and tumors may also express tumor-associated antigens (TAA) that may not be abundantly present in the donors. Donor T cells can recognize such mHAgs and TAAs as foreign antigens and generate an objective response against hematologic malignancies in a graft-versus-tumor (GVT) effect. However, a major side effect of HSCT occurs when donor T cells are alloreactive against the recipients’ normal cells, leading to graft-versus-host disease (GVHD). The ability to identify T cell clones …

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Design And Implementation Of An Eye Blink Controlled Human Computer Interface, Poonam Gwalani Apr 2011

Design And Implementation Of An Eye Blink Controlled Human Computer Interface, Poonam Gwalani

Theses and Dissertations

Advances in Human Computer Interface (HCI) have made this area of research important for improving the standard of living for people with disabilities. An eye blink system is presented to allow people with disabilities to control a standard computer mouse. This system is designed for people who are paralytic with no control over their arms, speech, and anyone who is restricted to only the control of eye and head movements. This system is based on infrared reflectivity to capture and analyze real time eye blink signal of the user. It uses simple economical hardware electronics to emulate the functionality of …

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Role Of Two-Component System Response Regulators In Virulence Of Streptococcus Pneumoniae Tigr4 In Infective Endocarditis, My Trinh Apr 2011

Role Of Two-Component System Response Regulators In Virulence Of Streptococcus Pneumoniae Tigr4 In Infective Endocarditis, My Trinh

Theses and Dissertations

Streptococci resident in the oral cavity have been linked to infective endocarditis (IE). While viridans streptococci are commonly studied and associated with IE, less research has been focused on Streptococcus pneumoniae. Two-component systems (TCSs), consisting of a histidine kinase (HK) protein and response regulator (RR) protein, are bacterial signaling systems that may mediate S. pneumoniae TIGR4 strain virulence in IE. To test this hypothesis, TCS RR mutants of TIGR4 were examined in vivo through use of rabbit models. There were 14 RR proteins identified and 13 RR mutants synthesized because SP_1227 was found to be essential. The requirement of the …

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Rebonding Anomic Communities With Theatre Of The Oppressed, Amanda Hauman Apr 2011

Rebonding Anomic Communities With Theatre Of The Oppressed, Amanda Hauman

Theses and Dissertations

This thesis explores whether Augusto Boal’s Theatre of the Oppressed (TO) can help anomic communities, affected by deindustrialization and globalization, in the U.S. Midwest, specifically looking at Saginaw, MI. After presenting a paper at the American Symposium for Theatre Research (ASTR) conference in 2009, the author attended a Theatre of the Oppressed facilitator training in Port Townsend, WA under the direction of Marc Weinblatt. She then conducted her own Theatre of the Oppressed workshop in Saginaw, MI to analyze the abilities of Theatre of the Oppressed in an anomic community. Each experience is detailed and followed by the author’s conclusions …

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Determining The Effect Of Double-Stranded Rna Treatment In Ovarian Cancer, Charlotte Roberts Apr 2011

Determining The Effect Of Double-Stranded Rna Treatment In Ovarian Cancer, Charlotte Roberts

Theses and Dissertations

DETERMINING THE EFFECT OF DOUBLE-STRANDED RNA TREATMENT IN OVARIAN CANCER By Charlotte Faye Roberts, B.A. A thesis submitted in partial fulfillment of the requirements for the degree of Masters of Science in Biochemistry at Virginia Commonwealth University.Virginia Commonwealth University, 2011Major Director: Jessica K. Bell, Ph.D.Assistant Professor, Department of Biochemistry & Molecular Biology. Epithelial ovarian cancer is a lethal gynecological malignancy. Due to its asymptomatic nature it is typically detected in the latter metastatic stages. Standard treatment protocol involves surgical cytoreduction, followed by a combination of taxane and platinum-based chemotherapeutics. Initially this treatment is successful however, most patients face recurring tumors …

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Trends In Dental Care For Individuals With Ectodermal Dysplasia, Justin Edwards Apr 2011

Trends In Dental Care For Individuals With Ectodermal Dysplasia, Justin Edwards

Theses and Dissertations

Purpose: The specific aim of this study is to evaluate the trends in dental health care for individuals with ectodermal dysplasia. Methods: This was a cross sectional analysis of subjects recruited through the National Foundation of Ectodermal Dysplasia (NFED). From 1997 to 2000, individuals with ectodermal dysplasia or their caregiver (if the individuals were too young to selfreport) voluntarily completed questionnaires. The questionnaire consisted of 37 items consisting of demographics, ectodermal dysplasia diagnosis, access to dental care, level of dental utilization, and type of dental services received. Descriptive statistics were used in addition to ANOVA analyses to evaluate the changing …

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Maternal Influences On The Development Of Infant Oral Biofilm, James Dibelka Apr 2011

Maternal Influences On The Development Of Infant Oral Biofilm, James Dibelka

Theses and Dissertations

Purpose: The purpose was to examine the maternal influences on the development of infant oral biofim and dominant bacterial strains of at risk populations. Methods: The study used a cross-sectional design to examine factors influencing biofilm colonization and the identification of bacterial strains transmitted from mother to child. Participants were enrolled in Children’s Health Involving Parents of Greater Richmond (CHIP). Plaque and saliva samples were collected from mothers and their children ages 6-36 months. The colonized oral bacteria strains of the mother infant dyads were then compared. Oral bacterial strain identification was completed using the HOMIM Forsythe microbe identification array. …

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Epicuria: The Dichotomy Of Richmond's Urban And Suburban Landscape In A Market Environment, Kate Canale Apr 2011

Epicuria: The Dichotomy Of Richmond's Urban And Suburban Landscape In A Market Environment, Kate Canale

Theses and Dissertations

This thesis examines the dichotomy of Richmond’s suburban and urban environments within a market environment. In our quest to make our lives more convenient, we have moved outside of cities, increased commutes and cut ourselves off from one another. Ultimately we have lowered our standards of quality in food, products and services by allowing big retailers and chain restaurants to determine a new standard of living. The goal of this works is to create a food hall and market environment that will act as a catalyst to improve the quality of life of Richmonders as well as to draw residents …

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Distinguishing Between Homeless And Unstably Housed Men On Risk Factors For Homelessness, Valerie Holton Apr 2011

Distinguishing Between Homeless And Unstably Housed Men On Risk Factors For Homelessness, Valerie Holton

Theses and Dissertations

This study explored the risk factors for homelessness in single men, the largest group of people experiencing homelessness and a group about which little is known regarding their risks for homelessness. A case control design was used to differentiate risk factors between men who were homeless and men who were unstably housed. Risk factors included cumulative risk, negative life events, and demographic factors. Two models were tested using discriminant function analysis (DFA). The Cumulative Risk Model did not significantly differentiate between the two groups. However, the Negative Life Events Model yielded one discriminant function that significantly differentiated between the groups …

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Spatial Parameters In Therapeutic Spaces: Design Of A Residential Treatment Facility For Eating Disorder Patients, Sarah Beth Basinger Apr 2011

Spatial Parameters In Therapeutic Spaces: Design Of A Residential Treatment Facility For Eating Disorder Patients, Sarah Beth Basinger

Theses and Dissertations

Can the built environment positively influence the treatment of an eating disorder? Does the built environment play a role in the quality of care, the rehabilitation process and the lasting affects of treatment in eating disorders and if so, what role does it play? What are the important parameters to consider in designing such a space? Currently there are few facilities designed specifically for the treatment of this disorder. Of those facilities, there is a lack of research regarding the effects of the built environment. Therefore, the process of answering these questions must begin by assessing parameters in architectural precedents …

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Women, Wealth And Social Norms Theory: Financial Behaviors And Perceptions Of Affluent Women In Their Prime Years, Scarlett Schwartz Apr 2011

Women, Wealth And Social Norms Theory: Financial Behaviors And Perceptions Of Affluent Women In Their Prime Years, Scarlett Schwartz

Theses and Dissertations

Financial security in retirement is an important social issue, yet many affluent women may have behaviors, attitudes or perceptions that could be detrimental to their financial security—putting them at risk for poverty in their retirement years. A survey was developed and implemented in 2009 to investigate the behaviors, attitudes, and perceptions regarding financial management among affluent ($250,000 or more of household investable assets) United States women in their prime years (aged 50–69) to determine if Social Norms Theory could be applied to this population. Three hypotheses were tested: 1.) most affluent prime-of-life women have “healthy” financial behaviors and attitudes; 2.) …

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Targeting The Endocannabinoid System To Reduce Nociception, Lamont Booker Apr 2011

Targeting The Endocannabinoid System To Reduce Nociception, Lamont Booker

Theses and Dissertations

Pain of various etiologies (e.g., visceral, inflammatory) can be a debilitating disorder that presents a problem of clinical relevance. While it is known that ∆9-tetrahydrocannabinol (THC) the primary psychoactive constituent found in marijuana produces analgesia in various rodent models of pain, its pharmacological properties are overshadowed by its psychomimetic effects. THC is the primary phytocannabinoid found in marijuana though other prevalent constituents such as the phytocannabinoids (e.g., cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), tetrahydrocannabivarin (THCV)) may possess antinociceptive actions without the psychomimetic effects associated with THC. Indeed, these phytocannabinoids act upon the endocannabinoid system (ECS) that is comprised of the …

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Developmental Trajectories Of Physical And Relational Aggression And Their Relation To Delinquency And Substance Use In Adolescence, Denicia Titchner Apr 2011

Developmental Trajectories Of Physical And Relational Aggression And Their Relation To Delinquency And Substance Use In Adolescence, Denicia Titchner

Theses and Dissertations

Although researchers studying adolescent aggression have proposed a conceptual distinction between physical and relational aggression, there is contradictory evidence regarding the degree to which they differ in their trajectories and relations to other outcomes. This study explored the importance of differentiating between these two forms of aggression based on comparisons of their trajectories, relation with each other, impact on delinquency and substance use, and gender differences. Data were collected as part of the Multisite Violence Prevention Project, conducted at 19 middle schools from four sites with a predominantly low-income, minority sample of students (N = 2,822). Growth curves showed significant …

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Assessment Of Diabetes Regimen Disease Care In Youth With Type 1 Diabetes Via The Diabetes Behavior Rating Scale And The 24-Hour Diabetes Interview, Kathryn Maher Apr 2011

Assessment Of Diabetes Regimen Disease Care In Youth With Type 1 Diabetes Via The Diabetes Behavior Rating Scale And The 24-Hour Diabetes Interview, Kathryn Maher

Theses and Dissertations

The psychometric properties of two measures of diabetes disease care, the Diabetes Behavior Rating Scale (DBRS) and the 24-hr Diabetes Interview (24-hr) were evaluated. The 24-hr is a widely used, structured interview while the DBRS is a self-administered, fixed-choice questionnaire. Both measures were administered to 250 youth with Type 1 Diabetes (aged 11–14 years) and their parents. Overall, both measures demonstrate adequate psychometric properties. The DBRS and the 24-hr demonstrated good incremental validity and low convergent validity with each adding significant additive value. Both measures demonstrated good concurrent validity with HbA1c. As expected, scores on the 24-hr demonstrated less than …

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Electrophysiological Characterization Of Enteric Neurons Isolated From The Immortomouse, Edward G. Hawkins Apr 2011

Electrophysiological Characterization Of Enteric Neurons Isolated From The Immortomouse, Edward G. Hawkins

Theses and Dissertations

The availability of murine genetic models is extremely advantageous to studying gastrointestinal function, but the benefits afforded by studying enteric neurons in mice has been hindered by their accessibility. Fetal (E13) and 2 day post-natal (P2) enteric neuron cell lines (IM-FEN and IM-PEN, respectively) were recently developed from the H-2Kb-tsA58 immortomouse. Our goal was to identify the electrophysiological properties of these cell lines and clarify their utility as a model of enteric neurons. IM-PEN cells stained positively for the neuron specific markers βIII-tubulin and PGP9.5 and were negative for the glial cell marker S100. Detection of mRNA for TRPA1, TRPV1, …

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Processing And Classification Of Physiological Signals Using Wavelet Transform And Machine Learning Algorithms, Abed Al-Raoof Bsoul Apr 2011

Processing And Classification Of Physiological Signals Using Wavelet Transform And Machine Learning Algorithms, Abed Al-Raoof Bsoul

Theses and Dissertations

Over the last century, physiological signals have been broadly analyzed and processed not only to assess the function of the human physiology, but also to better diagnose illnesses or injuries and provide treatment options for patients. In particular, Electrocardiogram (ECG), blood pressure (BP) and impedance are among the most important biomedical signals processed and analyzed. The majority of studies that utilize these signals attempt to diagnose important irregularities such as arrhythmia or blood loss by processing one of these signals. However, the relationship between them is not yet fully studied using computational methods. Therefore, a system that extract and combine …

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Suc Khoe La Quan Trong Hon Sac Dep! Health Is Better Than Beauty! Improving Breast And Cervical Cancer Screening Outcomes Among Vietnamese Women, Anh Nguyen Apr 2011

Suc Khoe La Quan Trong Hon Sac Dep! Health Is Better Than Beauty! Improving Breast And Cervical Cancer Screening Outcomes Among Vietnamese Women, Anh Nguyen

Theses and Dissertations

Vietnamese women experience cancer screening disparities and inconsistent adherence to screening guidelines. The goal of this study was to implement and evaluate a breast and cervical cancer screening intervention to promote cancer screening knowledge, attitudes, self-efficacy, intention, and behavior for Vietnamese women. Secondary objectives of the study included examining the relationships between cultural variables (e.g., acculturation, ethnic identity, religiosity, and collectivism) and cancer screening variables. The study enrolled 102 women from the greater Richmond metropolitan area. Participants were assigned to an intervention group or a print material control group. In the intervention session, participants were exposed to information on female …

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The Role Of The Propeptide And Its Residues In Activation And Secretion Of Elastase, An M4 Metalloprotease Secreted By Pseudomonas Aeruginosa, Emily Boice Apr 2011

The Role Of The Propeptide And Its Residues In Activation And Secretion Of Elastase, An M4 Metalloprotease Secreted By Pseudomonas Aeruginosa, Emily Boice

Theses and Dissertations

Pseudomonas aeruginosa secretes several proteases associated with pathogenesis, but the most abundant and active is elastase (M4 metalloendopeptidase). Elastase (lasB), is first synthesized as a preproenzyme, with a signal peptide, an 18-kDa N-terminal propeptide, and a 33-kDa mature domain. The propeptide functions as an intramolecular chaperone that is required for the folding and secretion of elastase, but ultimately is proteolytically removed and degraded. Previous research has identified the conserved residues in the propeptide of elastase as compared to other M4 protease precursors and showed some among them to be important for the production of active elastase. In this project, the …

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Factor Analysis Methods And Validity Evidence: A Systematic Review Of Instrument Development Across The Continuum Of Medical Education, Angela Wetzel Apr 2011

Factor Analysis Methods And Validity Evidence: A Systematic Review Of Instrument Development Across The Continuum Of Medical Education, Angela Wetzel

Theses and Dissertations

Previous systematic reviews indicate a lack of reporting of reliability and validity evidence in subsets of the medical education literature. Psychology and general education reviews of factor analysis also indicate gaps between current and best practices; yet, a comprehensive review of exploratory factor analysis in instrument development across the continuum of medical education had not been previously identified. Therefore, the purpose for this study was critical review of instrument development articles employing exploratory factor or principal component analysis published in medical education (2006-2010) to describe and assess the reporting of methods and validity evidence based on the Standards for Educational …

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Involvement Of P53 In The S-Phase Checkpoint During Nucleotide Deficiencies, Cortney Heyer Apr 2011

Involvement Of P53 In The S-Phase Checkpoint During Nucleotide Deficiencies, Cortney Heyer

Theses and Dissertations

Several classes of antimetabolites have been developed for the treatment of cancer, including numerous inhibitors of nucleotide biosynthesis. N-(phosphonacetyl)-L-aspartate (PALA) and hydroxyurea (HU) are two antimetabolites that inhibit nucleotide biosynthesis; PALA inhibits de novo pyrimidine synthesis and HU inhibits the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. Due to the similar mechanisms, it was thought that cancer cells would respond similarly to HU and PALA treatment. However, studies in this dissertation revealed strikingly different responses to either HU or PALA treatment in HCT116 cells. A cytoprotective S-phase arrest was activated upon HU treatment while PALA treatment failed to activate the …

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What It Means To Be A Man: Masculinity, Sexual Risk-Taking, And Hiv Testing Behavior Among Heterosexual African American Males, Jessica Johnson Apr 2011

What It Means To Be A Man: Masculinity, Sexual Risk-Taking, And Hiv Testing Behavior Among Heterosexual African American Males, Jessica Johnson

Theses and Dissertations

HIV/AIDS is a growing concern in the African American community. From 2005 to 2008, there was a 12% increase in HIV/AIDS diagnoses among African Americans (CDC, 2010a). African American males have higher rates of HIV/AIDS diagnoses than any other ethnic or racial groups. In 2006, 65% of the HIV/AIDS cases among African Americans were from adult males (CDC, 2010a). These higher rates are in part attributed to higher levels of sexual risk-taking including unprotected sex, sex with multiple partners, and sex with high-risk partners. African American adult men get tested at almost the same rate (52%) as African American women …

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Commonwealth Times 2011-04-25 Apr 2011

Commonwealth Times 2011-04-25

Commonwealth Times, 1969-

No abstract provided.

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Adam10 Exacerbation Of Allergic Disease Is Potentially Explained By Its Role In Cd23 Exosomal Sorting., Joel Mathews Apr 2011

Adam10 Exacerbation Of Allergic Disease Is Potentially Explained By Its Role In Cd23 Exosomal Sorting., Joel Mathews

Theses and Dissertations

CD23, the natural negative regulator of IgE, has been shown to be involved in asthma progression through its regulation of IgE. To investigate if its sheddase, ADAM10, is also involved in asthma progression, three mouse models were utilized; an IgE/mast cell dependent model, an IgE dependent, mast cell independent model and a mast cell and IgE independent model. Experimental asthma was then induced in mice which were selectively deficient for ADAM10 in B cells (ADAM10-/-) and compared to WT controls. The ADAM-/- mice had decreased signs of asthma, including eosinophilia, AHR and IgE synthesis in the IgE dependent model compared …

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Adapting Evidence-Based Treatments For Youth In A Community Mental Health Setting: Single Case Design, Alexis Quinoy Apr 2011

Adapting Evidence-Based Treatments For Youth In A Community Mental Health Setting: Single Case Design, Alexis Quinoy

Theses and Dissertations

This single-case design study examined the effectiveness of adapting evidence-based treatments (EBTs) for children in a community clinic through a university-community partnership. Community clinic therapists treated eight youths (five males), ages 10 to 14, of whom four were Caucasian, two were Latino, one was African-American, and one was Caucasian/African-American. Youths presented with a primary diagnosis of a DSM-IV (American Psychiatric Association, 1994) internalizing disorder (plus multiple comorbidities). An adapted treatment combining multiple elements based on two primary treatment manuals: Coping Cat (Kendall et al., 1990) and PASCET (Weisz et al., 1999) was used. Youths with comorbid externalizing symptoms were also …

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Sweet Mercy: A Scientific Investigation, Aubrey Gartner Apr 2011

Sweet Mercy: A Scientific Investigation, Aubrey Gartner

Theses and Dissertations

The purpose of the following studies is to understand the factors that are related to and influence a person’s merciful behavior toward an offender. I define mercy as an act by a person who has the authority to do so that administers or recommends less negative consequence or punishment than is deserved by someone justly deserved. In Study 1, undergraduate students (N = 400) completed the Mercy Meter, a self-report measure of mercy. The Mercy Meter’s scale structure and psychometric properties were examined using Item Response Theory Rasch Analysis. A 14-item, 2-factor scale was established with good psychometric properties. Evidence …

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The Effects Of Sdf-1Α Treatment On The Migration Of Neural Stem/Progenitor Cells After Traumatic Brain Injury, Corey Evans Apr 2011

The Effects Of Sdf-1Α Treatment On The Migration Of Neural Stem/Progenitor Cells After Traumatic Brain Injury, Corey Evans

Theses and Dissertations

Traumatic Brain Injury (TBI) is one of the leading causes of death and disability among young adults and has been a significant field in medical research over the past decades. Intensive studies focusing on how to repair tissue damage resulting from head injuries have discovered that the central nervous system (CNS) retains a regenerative capacity throughout life due to the persistent presence of neural stem/progenitor cells (NS/NPCs) in the neurogenic regions. In the normal brain, cells generated in the subventricular zone (SVZ) migrate along the rostral migratory stream (RMS) to the olfactory bulb and cells in the subgranular zone (SGZ) …

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Contextual Factors And Reproductive Control In U.S. Women, Brianna Magnusson Apr 2011

Contextual Factors And Reproductive Control In U.S. Women, Brianna Magnusson

Theses and Dissertations

Introduction: Access to family planning services is a major public health issue. State policies and funding for family planning services may increase access to contraceptive services and help women avoid unintended pregnancies. Study Design: We identified sexually active, fertile women participants of the National Survey of Family Growth (2006-2008). Women were categorized as consistent or inconsistent users of contraceptives based on self-report. States were classified based on 2006 Medicaid family planning waiver status (income expansions, limited expansions, or no Medicaid family planning expansions), 2006 public funding for family planning in dollars per woman, and insurance coverage of contraceptive mandate status …

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