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Development Of Physiologic Contact Models For Articular Surfaces, John Owen May 2011

Development Of Physiologic Contact Models For Articular Surfaces, John Owen

Theses and Dissertations

The superficial tangential zone (STZ) plays a significant role in normal articular cartilage’s ability to support loads and retain fluids. To date, tissue engineering efforts have not replicated normal STZ function in cartilage repairs. Finite element models were developed to examine the STZ’s role in normal and repaired articular surfaces under different contact conditions. Models were developed by incrementally adding improvements which culminated in contact loading of curved models by permeable and impermeable rigid surfaces and a normal cartilage layer. In the normal STZ, permeability was strain-dependent on volumetric strain; tension-compression nonlinearity modeled collagen behavior. Nonlinear geometry accounted for finite …

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Development Of Free-Label Sensing In Plastic Microfluidic Platforms Using Pulsed Streaming Potentials (Psp), Vera Fernando Luna May 2011

Development Of Free-Label Sensing In Plastic Microfluidic Platforms Using Pulsed Streaming Potentials (Psp), Vera Fernando Luna

Theses and Dissertations

This work deals with the development of a new label-free detection technique called Pulsed Streaming Potential (PSP). Its novelty relies on the adaptation of a classical electrokinetic phenomenon (streaming potential) into a tool which can evaluate molecular interplay in label-free fashion. Implementation of PSP to microfluidic platforms allowed the label-free sensing of binding events to plastic (modified and unmodified) surfaces. It was demonstrated the use of real time PSP in plastic microfluidic platforms for determination of kinetic parameters of the interaction of proteins and plastic surfaces. Moreover, initial change of PSP after adsorption of proteins showed to be proportional to …

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A Framework For Digital Emotions, Meghan Rosatelli May 2011

A Framework For Digital Emotions, Meghan Rosatelli

Theses and Dissertations

As new media become more ubiquitous, our emotional experiences in digital space are increasing exponentially as well. While there is much talk of “affective” computing and “affective” new media art, a disconnect exists between networked emotions and the popular media that they inhabit. This research presents a theoretical framework for assessing “digital emotions”—a term that describes the feedback process between digital technologies and the body with respect to short, networked inscriptions of emotion and the (re)experience of those inscriptions within the body and through digital space. Digital emotions display five basic characteristics that can be applied to a variety of …

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The Superfund Program Past And Present Funding Implications, Nicole Franklin May 2011

The Superfund Program Past And Present Funding Implications, Nicole Franklin

Theses and Dissertations

The present research examines the impact of not reauthorizing the Superfund taxes on the operations of the program. EPA NPL site status data were obtained from the EPA CERCLIS database for analysis in this study. Data were selected for the fiscal years 1981 to 2009 in four NPL listing status categories: proposal to the NPL, final NPL listing, deletion from the NPL, and achievement of construction completion. Since the Superfund tax expired in 1995, data from the 1981 to 1995 fiscal years and data from the 1996 to 2009 fiscal years were analyzed to determine if there were mean differences …

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Prenatal Alcohol Exposure Reduces Dendritic Spine Density Across Sensory Cortices, Francis Oppong May 2011

Prenatal Alcohol Exposure Reduces Dendritic Spine Density Across Sensory Cortices, Francis Oppong

Theses and Dissertations

Dendritic spines are the major site of excitatory synapses in cortex, and factors that reduce dendritic spine numbers will produce serious cortical processing deficits, such as has been demonstrated for mental retardation and other psychiatric disorders. Prenatal alcohol exposure also has detrimental effects on brain development that lead to Fetal Alcohol Spectrum Disorder (FASD), which results in reduction of dendritic spine numbers in the hippocampus, prefrontal cortex and somatosensory cortex. FASD also is associated with temporal processing disorders involving sequential auditory stimuli that would be processed in auditory cortical areas. However, it is unknown if the reduction of spine density …

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Comparison Of Adhesion Of Gutta Percha/Ah Plus® And Resilon/Epiphany® Se™ After A Final Rinse With Different Concentrations Of Ethanol, Suren Paravyan May 2011

Comparison Of Adhesion Of Gutta Percha/Ah Plus® And Resilon/Epiphany® Se™ After A Final Rinse With Different Concentrations Of Ethanol, Suren Paravyan

Theses and Dissertations

The purpose of this study was to evaluate effect of final rinse of ethanol on bond strength in teeth obturated with Gutta Percha (GP)/AH Plus® or Resilon/Epiphany®SE™. Thirty-two extracted human anterior teeth were shaped to size 30, 0.06 taper and subjected to an identical irrigation protocol. Specimens were randomly divided into eight groups according to final irrigating solution (saline, 70%, 95%, 100% ethanol) and obturation material. Two millimeter thick slices were obtained by sectioning each obturated root. Bond strength was determined using micropush-out assay. Data was analyzed using Student’s t-test. Obturation with GP/AH Plus® formed a statistically significant stronger bond …

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The Effect Of Insulating K-Type Files On Accuracy And Reliability As Used In Two Electronic Apex Locators, Timothy Finkler May 2011

The Effect Of Insulating K-Type Files On Accuracy And Reliability As Used In Two Electronic Apex Locators, Timothy Finkler

Theses and Dissertations

The purpose of this in-vitro study is to compare the accuracy and reliability of a 3rd and 4th generation electronic apex locator (EAL) in locating the apical foramen when using insulated and non-insulated K files. Forty extracted human adult single-rooted teeth were coronally sectioned and placed in agar. EAL determined tooth length measurements were compared to actual tooth measurements. Comparisons to the standard measures used correlation and paired t-test. Preliminary comparisons of the groups used ANOVA to compare the means and the Brown-Forsythe test to compare variance. In the final analyses, the measurements were compared using a repeated-measures mixed-model multiway …

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Comparison Of Epiphany® And Ah-Plus® Root Canal Sealer Penetration Of Dentinal Tubules: A Sem Study, Kalisha Jordan May 2011

Comparison Of Epiphany® And Ah-Plus® Root Canal Sealer Penetration Of Dentinal Tubules: A Sem Study, Kalisha Jordan

Theses and Dissertations

The purpose of this study was to evaluate the effect of a final rinse of ethanol on depth of sealer penetration in teeth obturated with Gutta Percha (GP)/AH-Plus® (Dentsply, De Trey GmbH, Konstanz, Germany) or Resilon/Epiphany® SE™ (Pentron Clinical Technologies, LLC, Wallingford, CT). Extracted human anterior teeth (n= 32) were shaped to size 30, 0.06 taper using nickel-titanium rotary files and subjected to an identical irrigation protocol. Specimens were randomly divided into eight groups according to final irrigating solution (saline, 70%, 95%, or 100% ethanol) and obturation material (GP/AH-Plus® or Resilon/EpiphanyÒ SE™). A 2mm thick slice was obtained by sectioning …

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The Effects Of A Fluoride Releasing Orthodontic Primer On Demineralization Around Brackets: An In-Vivo Study., Daniel Pennella May 2011

The Effects Of A Fluoride Releasing Orthodontic Primer On Demineralization Around Brackets: An In-Vivo Study., Daniel Pennella

Theses and Dissertations

The purpose of this study was to investigate the effects of a fluoride releasing orthodontic primer on demineralization adjacent to brackets. Twenty-two patients were recruited for this study. One premolar was randomly chosen as the experimental tooth, the contralateral tooth was the control. Teeth were visually analyzed for white spot lesions (WSLs). Knoop microhardness was used to determine hardness. Visual examination results showed no significant difference in the number of WSLs observed between Opal Seal and Transbond XT over the duration of this study. Solid conclusions could not be drawn from the results of microhardness testing. Therefore, it cannot be …

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Vapor Transport And Aerosol Dynamics In The Respiratory Airways, Geng Tian May 2011

Vapor Transport And Aerosol Dynamics In The Respiratory Airways, Geng Tian

Theses and Dissertations

Predicting vapor transport and aerosol dynamics in the respiratory airways is important for analyzing both environmental exposure and respiratory drug delivery. A large number of analytical models, computational studies, and experiments on vapor and aerosol transport in the respiratory tract have been conducted previously. However, a number of critical questions remain unanswered. In this study, computational fluid dynamics (CFD) is primarily employed with frequent comparisons to existing and new experimental data sets to address previously unanswered issues related to the transport of vapors and aerosol in the respiratory tract. The three objectives of this study are further described below. Objective …

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Investigations On The Micro-Scale Surface Interactions At The Tool And Workpiece Interface In Micro-Manufacturing Of Bipolar Plates For Proton Exchange Membrane Fuel Cells, Mevlut Fatih Peker May 2011

Investigations On The Micro-Scale Surface Interactions At The Tool And Workpiece Interface In Micro-Manufacturing Of Bipolar Plates For Proton Exchange Membrane Fuel Cells, Mevlut Fatih Peker

Theses and Dissertations

Micro-forming studies have been more attractive in recent years because of miniaturization trend. One of the promising metal forming processes, micro-stamping, provides durability, strength, surface finish, and low cost for metal products. Hence, it is considered a prominent method for fabricating bipolar plates (BPP) with micro-channel arrays on large metallic surfaces to be used in Proton Exchange Membrane Fuel Cells (PEMFC). Major concerns in micro-stamping of high volume BPPs are surface interactions between micro-stamping dies and blank metal plates, and tribological changes. These concerns play a critical role in determining the surface quality, channel formation, and dimensional precision of bipolar …

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Analysis Of Nfi-X3 And Stat3 Interaction And Its Functions, Etsegenet Tizazu May 2011

Analysis Of Nfi-X3 And Stat3 Interaction And Its Functions, Etsegenet Tizazu

Theses and Dissertations

YKL-40 is a secreted protein that is highly up-regulated in malignant glioblastoma (GBM). Its expression is correlated with the invasive nature of GBMs and poor diagnosis of patients (Nigro et al., 2005). Previous research has shown that in astrocytes and GBM cells, YKL-40 expression is regulated by two transcription factors, NFI-X3 and STAT3, which form a complex with each other (Singh et al., 2011). Here, we show that the N-terminal domain of NFI-X3 is sufficient and required for its interaction with STAT3. We also show that the DNA-binding domain of NFI-X3 is required to induce YKL-40 expression. Thus, the interaction …

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The Impact Of Overt And Relational Victimization On Adolescents' Well Being: Moderating Effects Of Ethnicity At The Individual And School Level, Krista Mehari May 2011

The Impact Of Overt And Relational Victimization On Adolescents' Well Being: Moderating Effects Of Ethnicity At The Individual And School Level, Krista Mehari

Theses and Dissertations

The sociocultural influence of ethnicity on peer victimization among youth has received little attention in the research literature. Individual ethnicity within school ethnic composition may influence the frequency of victimization and the effect of victimization on adolescents’ well being. The current study investigated these issues using a data set of 5,581 sixth grade students attending 37 schools located in four sites. Multilevel models examined the extent to which individual ethnicity within school ethnic composition influenced the frequency and impact of overt and relational victimization on changes in life satisfaction. Ethnic differences were found in the frequency of victimization, but these …

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Meaning Maintenance In Close Relationships, Daryl R. Van Tongeren May 2011

Meaning Maintenance In Close Relationships, Daryl R. Van Tongeren

Theses and Dissertations

The human motivation for meaning has been a longstanding topic of inquiry, and recent research has begun to investigate how individuals maintain a sense of meaning in life. Given the importance of social connectedness in human life, as well as the role of relationships in providing a sense of meaningfulness, the present investigation explored meaning maintenance within the domain of close relationships. Specifically, a theoretical model for interpersonal meaning maintenance is presented, which proposes that moral actions—particularly forgiveness—are oriented toward restoring relationship quality, and, in turn, meaning in life, in the wake of interpersonal transgressions. The tenets of this model …

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Making It Work: Credential And Employment Outcomes Of Out-Of-School Youth In Southside Virginia, Najmah Thomas May 2011

Making It Work: Credential And Employment Outcomes Of Out-Of-School Youth In Southside Virginia, Najmah Thomas

Theses and Dissertations

Entering the labor force is noted as one of the most significant role transitions of young adulthood. Multiple studies find that a significant portion of the nation’s young adult population has not been able to make this critical role transition successfully. The purpose of this dissertation is to identify factors that help out-of-school youth make a successful transition to postsecondary education and employment. The study analyzes data collected from a cohort of out-of-school youth who participated in employment and training programs operated in the state under the Workforce Investment Act (WIA) in Southside Virginia. The primary research question is why …

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Turning To The Bottle For Answers: Identifying Racial Differences In Predictors Of Risk Drinking Among College Women, Melody Mickens May 2011

Turning To The Bottle For Answers: Identifying Racial Differences In Predictors Of Risk Drinking Among College Women, Melody Mickens

Theses and Dissertations

Epidemiological data suggest that alcohol use and related problems have increased among college women. The current study examined psychosocial predictors of risk drinking in a sample of college women (N=360), whether race moderated this relationship. Potential predictors included: daily smoker; premenstrual syndrome (PMS) symptom severity; age at first alcohol use, negative affect, parental history of alcohol problems and minority status. Analyses found that somatic PMS symptom severity score, age of first alcohol use, daily smoking, age of first alcohol use and non-minority status were related. Findings suggest that minority group membership was associated with low risk drinking, while somatic PMS …

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A Novel Bioactive Glass-Enhanced Orthodontic Bonding Resin: A Shear Bond Strength Study, Cole Johnson May 2011

A Novel Bioactive Glass-Enhanced Orthodontic Bonding Resin: A Shear Bond Strength Study, Cole Johnson

Theses and Dissertations

Enamel decalcification caused by poor oral hygiene is a significant problem in orthodontics. Bioactive glass-containing resins have been shown to release Ca2+ ions into surrounding solution. The purpose of this study was to determine the shear bond strength of four different compositions of orthodontic resin prepared with bioactive glass (N=20). Premolars were bonded using one of four BAG-BOND compositions. Brackets were debonded and ARI scores were given. The mean shear bond strength was 7.23 ± 2.47 MPa (62 BAG-BOND), 8.25 ± 2.87 MPa (65 BAG-BOND), 8.78 ± 3.08 MPa (81BAG-BOND) and 5.80 ± 2.27 MPa (85 BAG-BOND). 65 and 81 …

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Cumulative Risks To Eastern Oysters, Crassostrea Virginica In The James River, Va, Vrushali Lele May 2011

Cumulative Risks To Eastern Oysters, Crassostrea Virginica In The James River, Va, Vrushali Lele

Theses and Dissertations

In an effort to apply Cumulative Risk Assessment (CRA) as developed by the U.S. EPA, the present study investigates the cumulative risks to Eastern oysters due to multiple stressors such as salinity, temperature and oxygen and carbon dioxide. I also compared the effectiveness of the Hazard Quotient Method (HQ) in CRA. Ambient conditions in the James River, VA were obtained from the Virginia DEQ database and respiratory responses were estimated using values from the literature. The multiple environmental stresses are evaluated using a probabilistic analysis that combines the environmental conditions. It was concluded that salinity was the most influential stressor …

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Patient Satisfaction With Sedation For Periodontal Surgery: A Randomized, Cross-Over Clinical Study, Jason Streem May 2011

Patient Satisfaction With Sedation For Periodontal Surgery: A Randomized, Cross-Over Clinical Study, Jason Streem

Theses and Dissertations

PURPOSE: To create a study designed to assess patient satisfaction and preference for oral versus intravenous sedation in conjunction with periodontal surgical procedures. METHODS: Twenty-six patients who required at least two periodontal surgery procedures and requested sedation for treatment, participated in our study at VCU Department of Periodontics. This was a randomized, cross-over design with groups which received an intravenous sedative regimen with or without oral sedation premedication for one surgery and oral sedation medication alone for the other surgery. The primary outcome measurement was the type of sedation preferred by the subject. RESULTS: 14/26 (53.8%) subjects indicated a preference …

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Completing The Circle: The Actor's Cool Down, Anna Kurtz May 2011

Completing The Circle: The Actor's Cool Down, Anna Kurtz

Theses and Dissertations

Physically, vocally, and physiologically something happens to the actor in rehearsal and performance that can impact the actor’s everyday life. Practitioners have described this as boundary blurring, emotional hangover, and post-dramatic stress. Even acting as a profession can breed stressful situations for the actor. Actors can combat the blurring, the hangover, and the stress through awareness and process. As a part of process, actors warm-up to prepare their bodies and voices and to transition from real life to stage life. An often ignored aspect of process, but no less significant than the warm-up, is the cool down. After researching the …

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Defining The Bacterial Flora Of Periodontal Pockets In Chronic Periodontitis Patients, Rafael Rodriguez May 2011

Defining The Bacterial Flora Of Periodontal Pockets In Chronic Periodontitis Patients, Rafael Rodriguez

Theses and Dissertations

PURPOSE: The purpose of this study is to describe the subgingival bacterial biodiversity in untreated chronic periodontitis patients through the use of next generation 16S rRNA molecular analysis, and to determine similarities or differences between deep and shallow pockets within the same patients. METHODS: The analysis involved paired subgingival plaque samples from 24 subjects diagnosed with Generalized Moderate to Severe Chronic Periodontitis. One sample was selected from a single site having a probing depth >5 mm (i.e. Deep Site), and the other from a site with a probing depth <3mm (i.e. Shallow Site) within each subject. Bacterial DNA amplification of the V4-V6 region of the 16S rRNA was performed. The amplicons were sequenced via 454 Roche Genome Sequencer FLX System. The identified sequences were evaluated, and then compared to calculated false discovery rates. RESULTS: A total of 119 independent microbial genera were identified within the samples analyzed. Seven genera were identified to be statistically significant (p<0.05) in their association to deep or shallow sites following t-test and boot strap randomization: Actinomyces (p=0.004), Methylobacterium (p=0.028), Veillonella (p=0.028), and Rothia (p=0.038), and Streptococcus (p=0.033) in Shallow sites; while Mycoplasma (p=0.007) and Fusobacterium (p=0.016) were associated with deep sites. However, taking into account the calculated false discovery rates, it is suggested that none of the 119 microbial genera identified in this study were significantly associated with either deep nor shallow sites. CONCLUSION: The microbial genera identified within this study to be associated with deep and shallow sites follows the traditional pattern anticipated from the literature. However, the calculated false discovery rates suggest that these results may have occurred by chance and not due to a true difference.

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The Actor As Vessel: A Journey Towards Citizen Artistry, Joseph Carlson May 2011

The Actor As Vessel: A Journey Towards Citizen Artistry, Joseph Carlson

Theses and Dissertations

This thesis is a personal journey examining the applications of Ritual Poetic Drama Within the African Continuum as developed by my mentor Dr. Tawnya Pettiford-Wates, to the profession of the dramatic artist whether they are actor, director, educator or producer, to the training of the dramatic artist as a means of empowering generative, self defined, self validating artists, and as a means of developing community specific dramas in the hopes of facilitating individual and personal revelation. Using the author’s personal experiences as evidence, it intends to affirm Ritual Poetic Drama Within the African Continuum as an emergent methodology for theatrical …

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What Are The Educational Aspirations Of African American Males Raised In Mother-Only Households?, Patsy Chavis May 2011

What Are The Educational Aspirations Of African American Males Raised In Mother-Only Households?, Patsy Chavis

Theses and Dissertations

The purpose of this study is to examine the relationship of Black males being raised in a mother-only household and their career aspirations. The absence of the father in a home stands at the forefront as the cause of family dysfunction, which subsequently leads to the destruction of many hopes and dreams of the Black male.Is a mother-only household a preconceived environment for failure for the Black male?

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Disaster Management Policy And People With Disabilities In The United States And Jamaica, Jessica Jagger May 2011

Disaster Management Policy And People With Disabilities In The United States And Jamaica, Jessica Jagger

Theses and Dissertations

Natural and human-influenced disasters impact every demographic group around the world. People with disabilities face unique barriers to disaster preparedness, mitigation, response, and recovery related to functional needs and societal barriers. This study examines the relationship between emergency management planners and disability communities, by exploring the intent of emergency management policy, implementation of the policy, and the experiences of people with disabilities in Jamaica and Virginia. In this study, 36 people with disabilities were interviewed about their experiences with disaster, and 18 planners were interviewed about the intent and implementation of disaster management plans. Participants were from different communities across …

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The Natural Polyphenol Resveratrol Potentiates The Lethality Of Hdac Inhibitors In Acute Myelogenous Leukemia Cells Through Multiple Mechanisms., Alae Abod Yaseen May 2011

The Natural Polyphenol Resveratrol Potentiates The Lethality Of Hdac Inhibitors In Acute Myelogenous Leukemia Cells Through Multiple Mechanisms., Alae Abod Yaseen

Theses and Dissertations

This study examined the mechanisms underlying the interactions between the natural polyphenol Resveratrol and HDAC inhibitors in both U937 myelomonocytic leukemia cell line and blood samples from AML patients and normal cord blood. Simultaneous exposure to Resveratrol and HDAC inhibitors (Vorinostat-SAHA or Panobinostat-LBH589) resulted in potentiating the lethality caused by any single agent of the combination, this interaction found to be synergistic at multiple concentrations. Exposing U937 cells to minimal toxic doses of Resveratrol and HDACIs results in release of mitochondrial pro-apoptotic proteins AIF and cytochrome c, pro-apoptotic caspase activation especially caspase-8, and induction of DNA damage. These events were …

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The Privatization Of Special Education, Judith Mckinney May 2011

The Privatization Of Special Education, Judith Mckinney

Theses and Dissertations

This study, The Privatization of Special Education, addresses a shift in the provision of special education and related services to students with disabilities in the Commonwealth of Virginia. Students with disabilities are being publicly placed in private day and residential schools at public expense. In Virginia, 125 private schools are licensed by the Virginia Department of Education to serve students with Disabilities. The purpose of this study was to develop a profile of programs, services, and interventions offered in private education schools. This nonexperimental design study focused on a secondary data source: the Virginia Department of Education, Private Schools for …

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The Influence Of Family Structure And Transitions On Parenting, Income, Residential Mobility, And Substance Initiation In Early Adolescence: A Comparison Of Caucasian And African American Youth, Sally Mays Apr 2011

The Influence Of Family Structure And Transitions On Parenting, Income, Residential Mobility, And Substance Initiation In Early Adolescence: A Comparison Of Caucasian And African American Youth, Sally Mays

Theses and Dissertations

The effect of family structure on youth adjustment has received increasing attention as historical trends in single parenting, divorce, remarriage, and cohabitation with partners and extended family members have produced a diverse constellation of structures. African American youth are less likely than Caucasian youth to live in an “intact” family. Links between family structure and a variety of indices of youth adjustment have been established, although a relatively understudied outcome is that of substance initiation, despite its association with dependence and other negative sequelae. The dynamic effect of transitions has additionally been less studied than the static effect of structure. …

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Can Interior Design Erase Architecture? The Integration Of A Pet Care Facility Into The Fan, Erin Brunner Apr 2011

Can Interior Design Erase Architecture? The Integration Of A Pet Care Facility Into The Fan, Erin Brunner

Theses and Dissertations

Many urban pet care and boarding facilities tend to rest on the outskirts of the community, in quasi-industrial and commercial areas. Far from the homes of the people who would use their services, the locations of these facilities are inconvenient for most. Students and the employed have trouble making time in their hectic schedules to give their pets the attention and activity they need to be healthy, and often, pets are left alone, sedentary, for a substantial portion of the day. But what if there was a pet care facility that was within walking distance from home that could provide …

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The Answer To A Maiden’S Prayer: Homer Cummings And The Origins Of The 1937 Court Packing Plan, Jason Carmichael Apr 2011

The Answer To A Maiden’S Prayer: Homer Cummings And The Origins Of The 1937 Court Packing Plan, Jason Carmichael

Theses and Dissertations

On February 5, 1937, President Franklin Roosevelt submitted to Congress “The Judiciary Reorganization Act of 1937,” often simply called the Court-packing bill. The president hoped to circumvent the Court, which for years had been overturning New Deal programs, by appointing six new justices. However, the bill disguised its true intentions behind a veil of improving judicial efficiency. This misdirection backfired; the bill failed and Roosevelt’s popularity plummeted just months after a landslide reelection. This thesis examines the origins of the infamous Court-packing bill. It argues that Roosevelt was largely a background figure in the development of the plan, as he …

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Discriminative Stimulus Properties Of 3-Substituent Rimonabant Analogs, D. Matthew Walentiny Apr 2011

Discriminative Stimulus Properties Of 3-Substituent Rimonabant Analogs, D. Matthew Walentiny

Theses and Dissertations

Cannabinoid agonists (e.g., THC) dose-dependently decrease locomotor activity and body temperature and produce antinociception and catalepsy. Drugs that produce this tetrad of effects within a limited dose range are likely to function as CB1 receptor agonists. A structure activity relationship study from our laboratory investigating analogs of the CB1 antagonist rimonabant revealed that certain alterations in the 3-substituent of rimonabant’s pyrazole core conferred agonist-like properties in the tetrad. Interestingly, these effects were present in CB1 -/- mice, and were not reversed by rimonabant in wild-type mice. The present study evaluated two novel 3-substituent rimonabant analogs, O-6629 and O-6658 in the …

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