Digital Commons Network^™

Surface Engineering On Functional Materials For Sustainable Environmental Research, Jianping Chen

Theses and Dissertations

My dissertation addresses the urgent need for environmental solutions by developing innovative materials and methods to reduce carbon dioxide (CO₂) emissions. It encompasses two main research initiatives: the creation of metal-organic frameworks (MOFs) using a microdroplet-based spray process, and the enhancement of electrochemical reduction (ECR) of CO₂.

A significant innovation in my work is a novel technique for MOF production, which utilizes atomized microdroplets of MOF precursor solutions. This method significantly reduces processing time and enhances scalability. Specifically, it produces copper 1,4-benzenedicarboxylate (Cu-BDC) MOFs, optimizing operating pressures and flow regimes to discover unique morphologies that could …

A Retrospective Chart Review Of Avulsion Injuries Treated At Virginia Commonwealth University., Ryan Hediger

Theses and Dissertations

A RETROSPECTIVE CHART REVIEW OF AVULSION INJURIES TREATED AT VIRGINIA COMMONWEALTH UNIVERSITY. By: Ryan Hediger, DMD

Objective: Outcomes related to healing following an avulsion injury are multifactorial. However, contemporary literature suggests that tooth survival can be enhanced after such injuries by promptly replanting the tooth and adhering to proper management guidelines. Despite the abundance of resources available, the actions taken immediately after the avulsion injury play a pivotal role in determining the fate of an avulsed tooth. The primary objective of the current investigation is to unveil prognostic factors associated with the survival of avulsed teeth.

Methods: A chart review …

Housing For Transgender And Gender Expansive People In The U.S. South, Aaron M. Kemmerer

Theses and Dissertations

Housing is a prominent issue for transgender and gender expansive (TGE) people around the world. There is a dearth of research about TGE people experiencing homelessness (TGE PEH) in the U.S. South. This dissertation aims to amplify the voices of TGE Southerners around the social concerns of housing and homelessness – this work also disrupts gendered and racialized narratives about housing injustice, exposing the salience of intersectional discrimination and cisgenderism in housing outcomes for TGE people. Using narrative and visual methods, this dissertation re-presents stories and recommendations from in-depth interview data collected from a small qualitative sample of Southern TGE …

A Critical Perspective On Supporting Parents In Facilitating Informal Steam Learning On Children's Early Literacy Development, Suzanne G. Alexandre

Theses and Dissertations

Considering that parents/caregivers and home environment play an influential role in a child’s school readiness and future academic success, this study sought to support parents in using facilitation strategies to engage their child in informal learning at home. In order to examine if access to support for parents of preschoolers influenced parents’ confidence in their ability to facilitate informal learning at home, the project used informal STEAM learning, for context. The study also examines the potential impact of informal STEAM learning on children's school readiness and early literacy skills and the intersections of parent involvement, STEAM, and school readiness through …

Exploring Drivers Of Sex-Based Disparities In Relapsing Multiple Sclerosis, Stephanie K. Buxhoeveden

Theses and Dissertations

Females are three times more susceptible to relapsing multiple sclerosis (MS) and males typically have more severe disease, but the molecular underpinnings of these sex-based disease disparities are unknown and represent a critical knowledge gap.Subject Population: Blood samples from a demographically homogenous group of treatment naïve males and females with relapsing-MS and healthy controls. Research Design: Cross-sectional combinatorial omics pilot study. Instruments: Whole transcriptomic analysis with messenger RNA (mRNA) expression profiling using next generation sequencing (RNA-seq) and micro-RNA (miRNA) expression using NanoString technology. Aim 1) Identify and compare the actively expressed mRNAs in the transcriptome of males and …

Biophilia: Developing A Taste For Care, Che'leah Shannon

Theses and Dissertations

People in materially developed cultures spend over 90% of their lives in buildings (Evans & McCoy, 1998). Commencing with the industrial revolution these materially developed cultures see most of their populus moving from the countryside to the city in search of work and better lives. The city, an urban and modern development of densely packed peoples, buildings, and infrastructure, has developed as an efficient solution to meet the needs of a cosmopolis.

The city has developed widely without a necessity or place for nature. The ground outside is paved with concrete, efficient and comfortable for travel, buildings are built high …

Learning Curve: Designing An Inclusive Early Childhood Learning Center, Sarah Alrumayh

Theses and Dissertations

This research centers on the improvement of early childhood education environments in hopes to reduce the disparities in outcomes among children aged 2-6, widely known as "the achievement gap." It sheds light on designing an inclusive, child-centered school for students with specific learning disabilities (SLD) and speech or language impairments (SLI). Drawing on the IDEA (Individuals with Disabilities Education Act), it underscores the benefits of integrating students with special education needs into mainstream education, thereby fostering inclusive learning environments. (IDEA, 1975).

The research question probes how to create a nurturing and adaptable school environment tailored to the diverse needs of …

Developing Machine Learning And Time-Series Analysis Methods With Applications In Diverse Fields, Muhammed Aljifri

Theses and Dissertations

This dissertation introduces methodologies that combine machine learning models with time-series analysis to tackle data analysis challenges in varied fields. The first study enhances the traditional cumulative sum control charts with machine learning models to leverage their predictive power for better detection of process shifts, applying this advanced control chart to monitor hospital readmission rates. The second project develops multi-layer models for predicting chemical concentrations from ultraviolet-visible spectroscopy data, specifically addressing the challenge of analyzing chemicals with a wide range of concentrations. The third study presents a new method for detecting multiple changepoints in autocorrelated ordinal time series, using the …

The Splice Index As A Prognostic Biomarker Of Strength And Function In Myotonic Dystrophy Type 1, Marina Provenzano

Theses and Dissertations

Myotonic dystrophy type 1 (DM1) is a slowly progressive, multisystem disorder caused by a CTG repeat expansion in the DMPK 3’UTR that leads to global dysregulation of alternative splicing. The resulting decline in physical function is slow, and no reliable biomarkers exist for predicting disease progression; however, an RNA mis-splicing biomarker associated with weakness may have utility in predicting functional outcomes. Here we validate the Splice Index (SI) as a potential biomarker of DM1-associated strength and function. Muscle biopsies of the tibialis anterior were collected from DM1-affected individuals at baseline (n = 46) and 3-months (n = 34), along with …

Adaptable And Trustworthy Machine Learning For Human Activity Recognition From Bioelectric Signals, Morgan S. Stuart

Theses and Dissertations

Enabling machines to learn measures of human activity from bioelectric signals has many applications in human-machine interaction and healthcare. However, labeled activity recognition datasets are costly to collect and highly varied, which challenges machine learning techniques that rely on large datasets. Furthermore, activity recognition in practice needs to account for user trust - models are motivated to enable interpretability, usability, and information privacy. The objective of this dissertation is to improve adaptability and trustworthiness of machine learning models for human activity recognition from bioelectric signals. We improve adaptability by developing pretraining techniques that initialize models for later specialization to unseen …

The Role Of Notch1 Signaling In Regulating Neurogenesis In The Olfactory Bulb Following Traumatic Brain Injury, Sarah A. Baig

Theses and Dissertations

In the United States, more than 20.5 million adults over the age of 40 suffer from olfactory dysfunction, with TBI attributing to 5-17% of all olfactory dysfunction cases. Although often initially undetected and less conspicuous than other cognitive and behavioral impairments, olfactory dysfunction may have a significant negative impact on patients' quality of life and ability to accomplish activities of daily living, therefore the pathophysiology of these disorders should be understood. The production of neural stem cells enhances the repair and regeneration of the injured brain following a TBI. One of the primary endogenous neural stem cell generation sites in …

Intersectionality, Racial Discrimination And Oral Healthcare Utilization Among Black Adults In Baltimore City, Maryland, Briona M. Phillips

Theses and Dissertations

INTRODUCTION: Oral health is essential for overall well-being, yet disparities persist, particularly among marginalized populations including Black adults. Limited access to and underutilization of oral healthcare services exacerbate these disparities. Discrimination, both individual and systemic, acts as a significant barrier to accessing care, contributing to disparities in oral health outcomes. Individuals facing discrimination experience mistrust and fear within oral healthcare settings, leading to delayed or avoided care. Therefore, investigating and addressing discrimination among Black adults is essential for promoting equitable access to oral healthcare, improving overall oral health outcomes, and lessening existing disparities.

PURPOSE: The purpose of this dissertation was …

Examining The Relationship Between Racism-Related Stress And Coping Among Black Adolescents: A Linked Lives Perspective, Kenna Yadeta

Theses and Dissertations

As Murry and colleagues (2018) note, racism serves as a family-level stressor, impacting both Black adolescents and their parents. As Black teens continue to experience frequent and varied racism experiences (English et al., 2020), their Black parents are facing a double challenge: bearing the weight of their own experiences with racism, while also parenting a Black adolescent through the same. Recent frameworks (e.g., Gilligan et al., 2018) highlight the linked experiences of Black families, in dealing with their stress and coping. As such, the current study aimed to explore the ways that both adolescent and parental experiences with racism related …

Insights Into The Characterization And Degradation Of Electrospun Polycaprolactone Scaffolds For Tissue Engineering Applications, Caleb B. Wells

Theses and Dissertations

Electrospun polymeric biodegradable scaffolds are essential in tissue engineering, particularly for Engineered Tissue Vascular Grafts (ETVGs), which promise advancements in treating coronary artery disease, peripheral arterial disease, congenital cardiovascular defects, and renal disease. These scaffolds present a solution to issues with autologous graft availability and durability. While large-diameter grafts in low-pressure environments have seen success, small-diameter grafts in high-flow scenarios remain challenging. Understanding polymeric scaffold degradation and behavior during incubation, especially under dynamic mechanical loading, is vital for clinical translation of small-caliber ETVGs.

This research focuses on characterizing the mechanical and microstructural properties of electrospun polycaprolactone (PCL) scaffolds and their …

Sides Of A Dime, Reinetta Van

Mighty Pen Project Anthology & Archive

A navy captain falls, hits her head, and has her life forever altered. Years later, she passes her annual physical in preparation for deployment, despite being disabled. A contemplation on how a person can be two things at once, and if they should be.

Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program …

Determining Effective Treatment Regimens For Breast Cancer Using Combined Immunotherapy And Chemotherapy In Vivo, Akhila Kunuthuru

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

Breast cancer has the highest incidence rate of all cancers globally in women, and those of African descent, especially West African females, face higher rates of triple-negative breast cancer (TNBC), a more aggressive form of breast cancer. Immunotherapy for breast cancer is a relatively new treatment option, and research is ongoing to identify the best combination treatments for increasing survival of those diagnosed with TNBC. Eganelisib (IPI-549: a PI3K-gamma inhibitor that works to shift M2 macrophages to M1 to augment T cell function) with other combinatory treatments has shown promising results in reducing tumor growth and increasing survival in mice. …

Solutions To Period Poverty In The United States, Sanya Surya

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

Many women around the world lack access to menstrual hygiene products and hygienic, private sanitation facilities: an issue commonly known as “period poverty”. Women who experience this phenomenon often resort to unhealthy alternatives, putting them at higher risk for infections. Period poverty also causes many women to miss significant amounts of school and/or work, resulting in school drop-outs and adverse career outcomes. Menstrual inequities have recently come under greater study in low- to middle-income countries, but evidence suggests that women in the United States are adversely affected by period poverty as well. With this in mind, I set out to …

Persistence Of Wastewater-Associated Antibiotic Resistant Bacteria In River Microcosms, Aoife P. Mahaney

Theses and Dissertations

The spread of antibiotic-resistant bacteria (ARB) associated with wastewater is a significant environmental concern, but little is known about the persistence and proliferation of these organisms in receiving water bodies after discharge. To address this knowledge gap, we performed a series of microcosm experiments in which river water was amended with either untreated or treated wastewater, and the abundance of viable ciprofloxacin-, Bactrim-, and erythromycin-resistant bacteria was monitored for 72 hours.

Both types of wastewater amendments increased the initial abundance of ARB compared to microcosms containing only river water. The increase was greatest with untreated wastewater, but that effect decreased …

Haven: Exploring Trauma-Informed Design In Transitional Housing For Women And Children, Sydney J. Rakes

Theses and Dissertations

relevance

For 15 years, I have been a volunteer at a shelter for women and children. I interact with families and women who are suffering from the trauma caused by homelessness and domestic violence. In my observations, I have learned some spaces are more conducive to the staff and resident experiences than others. This project will be addressing how transitional housing for women and children can be designed to support the healing of trauma caused by domestic violence.

As of July 2023, there were about 150 women suffering from homelessness locally in the city of Richmond, Virginia (Homeward VA, 2023). …

Effects And Mechanisms Of Smartphone-Based Mindfulness Training On Emotional Experience, Polina Beloborodova

Theses and Dissertations

Emotional well-being is an important component of mental and physical health that includes both positive emotions and an absence of emotional symptoms (e.g., depressive- and anxiety-related). In this study, we examine psychological mechanisms that help to explain the effects of an digital mindfulness-based intervention (MBI) on emotional states. We conducted a randomized controlled trial wherein undergraduate student participants vulnerable to decreased positive and increased negative affect received a 2-week smartphone-based MBI or a structurally equivalent coping control intervention. Emotional experience, including depressive feelings, anxiety, and happiness, as well as subjective social well-being, including loneliness and felt connection to others, was …

A Walk In The Woods, Caitlin Mclean

Theses and Dissertations

A connection with nature fosters increased appreciation, admiration, and responsibility toward the natural environment, thus encouraging the mindful use of its resources and preservation of both species and their habitats. Defined by Mayer and Frantz (2004) as an “experiential sense of oneness with the natural world”, this connection is more important now than ever in this highly digital era. Studies indicate that limited exposure to nature can negatively impact the activation of neural pathways associated with pro-environmental attitudes and behaviors (Chawla, 2020), while further research shows that engagement with the outdoors during childhood as a significant life experience (Chawla, 1998), …

"I Call Them Supermoms": Therapists' Reflections On The Impact Of Youth Sexual Offending On Latina Mothers, Mauricio P. Yabar

Theses and Dissertations

Families of youth who have sexually offended often suffer significant collateral consequences following the discovery of the sexual offense. Samples in research with these families disproportionately consist of mothers and other female parental figures. This is rarely acknowledged in the literature, and the experiences of these mothers have not been explicitly examined. In addition, research on the experiences of these families has largely ignored factors related to race and ethnicity. This is a significant oversight considering the prevalence of systemic racism and discrimination in the United States, particularly in the systems with which these families must interact (e.g., juvenile justice …

Evaluating The Role Of Interoceptive Awareness In Insomnia And Across The Sleep Health Spectrum, Lara Lobrutto

Theses and Dissertations

Interoceptive awareness, characterized by a non-judgmental and trusting attitude towards body sensations, is an understudied construct that is implicated in sleep and health outcomes. Interoceptive awareness is cultivated via contemplative and mindfulness-based practices. Given that it may be utilized to reduce pre-sleep arousal, which is a key mechanism in insomnia, interoceptive awareness is posited to be a protective factor for sleep health. A cross-sectional study was conducted among undergraduate university students (N = 420) in the Mid-Atlantic region of the United States to assess the association between interoceptive awareness and sleep outcomes. Participants received a survey link and completed …

Cardiometabolic Genomics And Pharmacogenomics In Filipino Americans: A Cross-Sectional Study, Khalifa Y. Alrajeh

Theses and Dissertations

Background: Heart disease remains a leading cause of death in the country, with significant ethnic disparities. Filipino Americans (FAs), the third-largest Asian subgroup in U.S., face an elevated burden of dyslipidemia, a primary modifiable risk factor for heart disease. Objectives: This community-based study addresses critical knowledge gaps by characterizing the cardiometabolic and genetic factors contributing to dyslipidemia among FAs and implications for personalized cardiovascular drug therapies, particularly statin pharmacogenomics (PGx). Methods: We characterized dyslipidemia prevalence in FAs and major ethnic subgroups using nationally representative NHANES data. We examined associations between uric acid (UA) levels and lipid profiles, …

Trans And Gender Diverse Inclusion In Academic Library Hiring, Keahi K. Adolpho, Stephen G. Krueger, Luke Sutherland, Adrian Williams

VCU Libraries Faculty and Staff Publications

We do not know how many trans and gender diverse people work in libraries in the United States. Like the US Census, the American Library Association’s demographic survey of its members (which is by no means a complete or accurate representation of the profession) asks if respondents are male or female (Rosa & Henke, 2017). In addition to erasing anybody who is not one of these two things, this question does not provide information on whether respondents are trans or gender diverse. And yet, we are here: all four of the authors of this chapter are trans people who work …

Covid-19 Vaccine And Infection And The Relationship To Lichen Planus Flare-Ups: A Self-Reported Survey Study, Sara Kube

Theses and Dissertations

Purpose: The aim of this study was to determine if there is an increased occurrence of oral lichen planus flare-ups after COVID-19 vaccination or infection.

Methods: An 11-item questionnaire was dispersed to patients with a diagnosis of oral lichen planus. The survey contained questions regarding the patient’s history of COVID-19 vaccination and infection as it relates subjective oral lichen planus flare-ups (i.e. oral redness, oral ulcerations, and/or oral pain/discomfort).

Results: Self-reported flares were significantly associated with whether or not vaccine side effects were also reported (p-value=0.0053). For those who reported experiencing side effects (tiredness, headache, muscle pain, chills, fever, nausea), …

Family Rejection And Affirmation Experiences Among Racially And Ethnically Marginalized Youth Who Identify As Transgender And/Or Gender Diverse, Angela Matijczak

Theses and Dissertations

Relationships with family members can be a vital source of support, and significant stressor, that contributes to mental health outcomes among transgender and gender diverse young adults who are racially and ethnically marginalized (TGD REMY). Guided by a life history narrative approach, this qualitative study explored family affirmation and rejection among TGD REMY across three aims: (a) how TGD REMY define their experiences of family rejection and/or affirmation, (b) whether and how experiences of rejection/affirmation change throughout the lifetime, and (c) whether and how experiences of rejection/affirmation differ by each family member. Semi-structured interviews were conducted with 17 TGD REMY …

Identifying Mechanistic Pathways To Rigidity Associated With Obsessive-Compulsive Personality Disorder Traits Using A Novel Decision-Making Paradigm, Hannah L. Heintz

Theses and Dissertations

Cognitive and behavioral rigidity is observed across several mental disorders and is a defining characteristic of Obsessive-Compulsive Personality Disorder (OCPD), a highly prevalent and debilitating, yet understudied, disorder. In particular, treatments for OCPD are underdeveloped due to our poor understanding of the mechanisms leading to the disorder’s key feature of rigidity. Two related disorders, anorexia nervosa (AN) and obsessive-compulsive disorder (OCD), have shown distinct mechanistic pathways leading to symptoms of rigidity, indicating that this trait can arise as a result of a number of differentially impaired cognitive processes, each requiring unique interventions. To examine the relationship between symptoms of OCPD …

Full Issue

Journal of Mathematics and Science: Collaborative Explorations

No abstract provided.

Two Decades Of Supporting Excellence In Stem Through Programs That Work: A History Of High-Quality Stem Programming In The Commonwealth Of Virginia, Bill Haver, Deborah Neely-Fisher

Journal of Mathematics and Science: Collaborative Explorations

The Virginia Mathematics and Science Coalition annually recognizes effective science, technology, engineering, and mathematics (STEM) programs. The leaders of these Programs That Work receive recognition and others gain ideas to incorporate into their STEM programs. Programs That Work was initiated in March 2000 as a part of a statewide conference designed to better understand effective strategies to increase the success of women, minorities and members of other groups who had been underrepresented in STEM. Programs That Work has since expanded to include effective STEM programming for all students and teachers at all levels by recognizing school systems, colleges and universities …