Digital Commons Network^™

Latent Profiles Of Child Coping And Perception Of Experience Processes To Predict Long-Term Symptoms Of Depression, Intrusive Grief, And Suicidality Outcomes In Parentally Bereaved Children, Rebecca Hoppe

Theses and Dissertations

Childhood bereavement is a significant public health issue and the most distressing form of childhood trauma. The death of a parent can disrupt the course of a children's development and potentially predispose them to enduring adverse mental health outcomes, such as depression, intrusive grief, and suicidality. Recognizing grief as a dynamic process, theories have suggested that children’s unique coping and perceptions of experience can contribute to variations in individual adaptations to the death and the onset of mental health problems. The goals of this study were to (a) use latent profile analysis to empirically group recently bereaved children into distinct …

An Application Of Cfd To Support The Development Of Treatment Strategies And Technology For The Management Of Cystic Fibrosis In Pediatric Patients, Morgan L. Thomas

Theses and Dissertations

Inhaled medications are a key treatment modality in multiple lung-related diseases and disorders. Considering children with cystic fibrosis (CF), improvements in the delivery of aerosol antibiotics have the potential to better eradicate bacterial lung infections, preserve lung function and thereby further extend lifespans and quality of life. The overall objective of this dissertation was to expand and validate CFD models for predicting the deposition of pharmaceutical aerosols throughout the airways and apply these models to understand the targeted delivery of inhaled antibiotics to children with CF. To accomplish this goal, three contributions were made. First, CFD methodologies for modeling aerosol …

Considering Personal And Professional Identities: The Collaborative Experiences Of School Speech-Language Pathologists, Imani Evans

Theses and Dissertations

My three-paper dissertation explored the interrelatedness between two critical issues in special education: interdisciplinary collaboration and sociocultural identity. I examined both through the perspectives of one discipline of specialized instructional support personnel (SISP). In the first paper, I conducted a systematic literature review examining the current empirical evidence on speech-language pathologists’ (SLPs) collaboration in schools. A key takeaway from the literature review was the need for qualitative research to better understand the depth and breadth of collaborative experiences. In the second paper, I utilized an exploratory qualitative design and pilot data to discuss school-based SLPs’ shared collaborative experiences, identifying common …

The Compass, Summer 2024

The Compass, 2018-

The Compass is an annual orientation guide for VCU students produced by the Student Media Collective in the VCU Student Media Centered. The guide is distributed physically during summer orientation sessions for new and transfer students. The publication includes short articles, illustrations, letters of welcome from students and administrators, comics, and advertisements from VCU and Richmond organizations.

Effects Of Mindfulness Training On Prosocial Responses In Intergroup Relations: A Pilot Randomized Controlled Trial, Denise Yiran Zheng

Theses and Dissertations

Based on social identity theory and intergroup emotions theory, individuals feel for and act toward others based on their group-based social identities. Recent research shows that mindfulness can enhance prosocial responses toward others across group divides. The current research examined the effects of mindfulness training on prosocial behavior in intergroup relations where such behavior is difficult (e.g., with marginalized or devalued social groups). The study also examined potential mechanisms, namely state empathic concern and appraisal, that may explain how mindfulness increases prosocial behavior toward outgroups. This study compared the effects of a 2-week mindfulness training to a matched coping training …

Outcomes Of Anterior Crossbite Correction On Alveolar Bone Morphology In Patients With Cleft Lip And Palate, Katherine J. Hayes

Theses and Dissertations

Objective: To determine if patients with cleft lip and/or cleft palate (CLP) with dental correction of the anterior crossbite during growth display differences in alveolar bone thickness around the maxillary central incisors compared to patients without crossbite correction.

Methods: This retrospective study evaluated post-treatment cone beam computed tomography (CBCT) images of growing patients with CLP with anterior crossbites who underwent Phase I orthodontic treatment (n=32). CBCTs were sorted by whether the crossbite was corrected (n=16) or not corrected (n=16) during Phase I. Alveolar bone thickness was measured on the buccal and palatal aspects of the central incisors at 3 mm, …

The Effects Of Various Nanoplastics On The Inflammatory Response In Primary Alveolar Epithelial Cells, Eunice J. Pak

Theses and Dissertations

As plastic pollution begins to multiply in the environment and the workplace, gradual degradation of these plastics creates an unseen threat to biological health: nanoplastics. These nanoplastics are common in day-to-day life, and have been found in various internal organs of the human body. The biological and health effects of these nanoplastics are still widely unknown, and only recently has research focused on the impacts of these particles on human health at the cellular level.

In this thesis, poly(methyl methacrylate) and three forms of polystyrene (carboxyl-modified, amine-modified, and neutral surface charge) have been tested on submerged primary C57BL/6 mouse alveolar …

The Effect Of Experienced Compassion At Work On Nursing Home Certified Nursing Assistants' Well-Being And Turnover Intentions, Kristin M. Macdonald

Theses and Dissertations

Statement of problem and objectives: Could experienced compassion at work alleviate nursing home certified nursing assistant (CNA) burnout? This study investigates whether experienced compassion at work predicts higher well-being (meaningfulness of work, psychological vitality, and resilience) for CNAs, and if well-being predicts lower turnover intentions.

Procedure followed: This is a prospective, observational, survey-based study with three timepoint data collection. Convenience sampling of Kansas and Virginia NHs was conducted (n=13). All CNAs working at the NHs were study eligible. CNAs received gift cards with laddered incentives for ongoing participation. There was in-person administration of a CNA survey at each timepoint. …

Planning Growth Management; The Rapid Urbanization Of Loudoun County, Virginia, Shaianna Trump

Theses and Dissertations

As the population grows, planners and politicians must decide how to direct growth. This thesis analyzes how growth management can control land use and development using Loudoun County, Virginia, as a case study. By looking at how Loudoun County has implemented growth management policies, a case can be made for why governments should look to growth management to manage growth pressures. This thesis looks at the past and present growth management policies in Loudoun County and analyzes the County’s 2019 Comprehensive Plan.

How To Forget, Jesse D. Hoyle

Theses and Dissertations

How To Forget was born from a need to give tangible form to the psychic residue left behind by a life lived. Through the use of silk-screening of red clay mud onto ink-jet photographs, archival textiles, and site-specific installations, I attempt to tie and/or divorce myself from my own and my family's extended history and examine the function of memory within the dynamics of the archive. How To Forget takes a non-linear, non-chronological approach to this examination, compressing decades of time and space through the manipulation of the archive and my own self-portraiture, designed specifically to deny myself from its …

The Effect Of 17Β Estradiol On Local Production Of Active Vitamin D3 Metabolites In Laryngeal Squamous Cell Carcinoma, Tillat Batool

Theses and Dissertations

Laryngeal squamous cell carcinoma (LSCC) has garnered attention as a sex-hormone-dependent cancer with notable responsiveness to 17β-estradiol (E₂), in which it’s tumorigenesis can be mediated through estrogen receptors (ER). The ESR1 gene encodes for the classical full-length ERα66, as well as splice variants ERα36 and ERα46. Previous studies have shown that an active vitamin D₃metabolite, 24R,25(OH)₂D_3. has pro-tumorigenic or anti-tumorigenic responses in LSCC cells with different ER profiles, and that the tumor cells have the capability of localized production of vitamin D metabolites at the cellular level when treated with 25(OH)D₃-d6 …

Obstacles To And Facilitators Of Services In Child Welfare In The Context Of The Family First Prevention Services Act, Juliet Wu

Theses and Dissertations

The child welfare system has generally focused on child wellbeing and protection in the context of abuse or neglect allegation, supporting caregivers with child rearing, and finding a stable, permanent home for children. Because children and caregivers involved with the child welfare system typically have complex needs, public departments of social services often collaborate with other entities to provide services to families. However, connecting families to services has often been difficult, with many barriers along the way that prevent families from receiving the services they need. The enactment of the Family First Prevention Services Act (FFPSA) in 2018 aimed to …

Re-Programming Transcription Factor Function For Neuroscience Research Of Addiction: Investigating The Role Of Zinc Finger Proteins In Driving Cocaine Reinforcement In Mice, Joseph A. Picone

Theses and Dissertations

Administration of addictive drugs like cocaine or morphine initiates aberrant gene transcription within brain reward circuitry neurons, which contributes to the lasting behavioral maladaptations that define addiction. The drug-induced expression and function of key brain transcription factors (TFs) is one major mechanism through which these drugs are able to regulate transcription, and as a consequence, lasting damaging drug-related behaviors including compulsive drug use. The goal of this dissertation is to more fully understand the molecular mechanistic drug-specific actions of TFs within the rodent nucleus accumbens (NAc). The findings from these studies could serve as the basis to identify novel candidate …

The Cultural Adaptation Of An Eating Disorders Assessment Tool For South Asian American Women, Neha J. Goel

Theses and Dissertations

South Asians (SAs) are less likely to be screened, referred, and treated for eating disorders (EDs), although they experience these serious health conditions at rates similar to those of their White counterparts. Available ED assessment tools do not adequately capture cultural nuances in the presentation of eating psychopathology in SAs. Thus, the current study culturally adapted the Eating Disorder Examination-Questionnaire (EDE-Q) to enhance its validity, applicability, and cultural relevance for SA women living in the US. During the cultural adaptation phase, the principal investigator consulted with participant experts (N=24) and research experts (n=4) to create the …

A Multilevel, Mixed Methods Examination Of Food Insecurity, Housing Instability, And Cardiovascular Health, Sarah Collins

Theses and Dissertations

BACKGROUND

Housing instability and food access are both robust risk factors for cardiovascular disease (CVD), which claims more lives annually in the U.S. than cancer and chronic lung disease combined. We hypothesized that experiencing both housing instability and food insecurity would have an additive effect on CVD risk, resulting in elevated blood pressure (BP) and perceived stress among young adults (YA).

METHODS

This research examined the relationships between food insecurity, housing instability, stress, and cardiovascular disease risk through three aims. First, multivariate linear regression was used to assess associations among YA, focusing on eviction, food insecurity, and blood pressure. Second, …

Transgender Perceptions Of Breast Health Care And Utilization Of Preventative Breast Imaging Services, Cherish Parham

Theses and Dissertations

Little information exists on transgender patient perceptions of breast imaging care at mammography facilities. The purpose of this descriptive phenomenological study was to understand the lived experiences of transgender patients at mammography facilities, their knowledge of breast care, and how these experiences have shaped their perceptions of the breast imaging community and attitude toward breast cancer screening. By applying the revised the Gelberg-Andersen Behavioral Model for Vulnerable Populations, this study addressed factors specific to the transgender population that may affect their healthcare utilization and how that impacts health outcomes. Researchers collected data from transgender/non-binary individuals in the Richmond, Virginia region …

Efficient Connectivity Management And Path Planning For Iot And Uav Networks, Amirahmad Chapnevis

Theses and Dissertations

This dissertation explores how to better manage resources in mobile networks, especially for enhancing the performance of Unmanned Aerial Vehicles (UAV)-supported IoT networks. We explored ways to set up a flexible communication architecture that can handle large IoT deployments by making good use of mobile core network resources like bearers and data paths. We developed strategies that meet the needs of IoT networks and enhance network performance. We also developed and tested a system that combines traffic from several mobile devices that use the same user identity and network resources within the core mobile network. We used everyday smartphones, SIM …

Analyzing The Role Of Slc25a32 In Hepatocellular Carcinoma, Mimansha Shah

Theses and Dissertations

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide. Despite advances in understanding its molecular pathogenesis, treatment options for HCC remain limited, highlighting the need for identifying novel therapeutic targets. This study investigates the role of SLC25A32, a mitochondrial transporter gene located on chromosome 8q22.3, in HCC progression. SLC25A32 is involved in the transport of tetrahydrofolate (THF) and flavin adenine dinucleotide (FAD) into mitochondria, playing a crucial role in one-carbon metabolism and redox balance. Using CRISPR/Cas9 technology, we generated potential SLC25A32 knockout clones in the HCC cell line Huh-7. Quantitative PCR …

Shape Inverse Prediction Of Magnetic Field-Actuated Soft Robots By Neural Network Machine Learning, Lineth J. Perez Monsalve

Theses and Dissertations

Soft robotics has drawn tremendous interest in recent years because the compliance and motion of soft robotics enable biocompatibility and versatility for many applications, such as human-machine interaction, wearable and assistive devices, and health monitoring. This study introduces a novel predictive modeling approach using neural networks for shape control of magnetic soft robots. The robots are made of silicone materials embedded with hard magnetic particles, which respond to the external magnetic field provided by a ring-type of permanent magnet. These robots, free from physical connections to external devices, i.e., non-tethered actuation, hold significant potential for applications in healthcare, such as …

Role Of Human Intermediate Form Prl Receptor I-Tail In The Pathogenesis Of Breast Cancer, Shanwei Shen

Theses and Dissertations

Breast cancer continues to be the second most common cancer in women in the United States. The neuroendocrine hormone human prolactin (hPRL) plays an important role in normal mammary gland development and growth, stimulating normal breast tissue proliferation and differentiation. Considerable evidence has shown that hPRL is involved in the malignant transformation of human breast tissue. hPRL enhances viability, invasiveness, and proliferation of breast cancer cells in vitro. Evidence from epidemiologic and genetic studies also implicates role of hPRL in the pathogenesis of breast cancer. Its cognate receptor the human prolactin receptor (hPRLr) is required for the action of hPRL. …

Fat And Water Content Effects Of Three Food Substrates (Ground Veal, Ground Beef, And Beef Liver) On Lucilia Sericata (Diptera: Calliphoridae) Development And Mortality, Nicole Dailey

Master of Science in Forensic Science Directed Research Projects

Although temperature has been identified as the most important catalyst affecting blow fly larval development, other variables encountered by these species, such as the fat and moisture content of the food source, may have an impact on accurate estimations of the PMImin in forensic investigations. Thus, body composition differences between human carrion, such as variations in body fat and water percentages between younger and older individuals, or heavier persons, could affect blow fly developmental rates, and in turn cause over or under estimations of the PMImin. In this study, the weight, length, and development times of Lucilia sericata third instar …

The Development And Evaluation Of A Method For Complete Collagenase I Digestion Of Bos Taurus Bone Samples, Reilly Price

Master of Science in Forensic Science Directed Research Projects

Current methods for processing aged forensic bone samples for DNA analysis involve pulverization and organic extraction, which further destroys already degraded DNA and uses large amounts of limited samples. Additionally, the success rates for this type of analysis vary widely as homogenization incorporates PCR inhibitors into the sample. Little research has explored how pulverization results in DNA damage in profiles obtained from skeletal remains. This study proposes an enzymatic digestion method to separate osteocytes from PCR inhibitors in the extracellular bone matrix to improve the quality and quantity of DNA isolated from aged bone samples. The technique described here used …

A Novel Dual Configuration Dart/Uhplc-Ms/Ms System For The Rapid Analysis Of Psilocybin-Containing Mushrooms And Other Seized-Drug Submissions, Aron R. Jaffe

Master of Science in Forensic Science Directed Research Projects

The use and availability of controlled substances is highly dynamic. When a classical or novel psychoactive substance becomes popular, an influx of seized-drug evidence submissions closely follows, contributing to an ever-growing backlog of exhibits awaiting identification. The need for inclusive, rapid, and robust analytical methods is apparent, as demonstrated by recent growth in hallucinogen use. Psilocybin and psilocin, among other entheogens, have become increasingly popular and an increase of psilocybin mushroom seizures by law enforcement has followed. The structural similarity and thermal lability of many entheogens preclude their identification using many conventional analysis techniques. A DART and UHPLC were interchangeably …

Using The Microbiome To Assess The Health Status Of The Individuals Recovered From The East Marshall Street Well, Arian Karim

Master of Science in Forensic Science Directed Research Projects

In 1994, during the construction of the Kontos Building on the Medical College of Virginia Campus, a well on East Marshall Street was discovered to contain artifacts and human remains of African descent. Upon archaeological analysis by the Smithsonian, the ancestral remains can be dated back to the mid-19th century, when grave robbing and the use of cadavers for anatomical purposes [BS1] in medical schools were common. The human oral microbiome is the second largest human microbiota, containing over 600 species of organisms. Dysbiosis of the oral microbiome can lead to the overgrowth of pathogenic species, resulting in illness and …

Assessing The Effectiveness Of Alternative Light Sources In The Search For Skeletal Remains, Oiivia L. Thompson

Master of Science in Forensic Science Directed Research Projects

Many search and recovery operations for human skeletal remains are unsuccessful due to difficulties recognizing bones in outdoor environments even when evidence indicates the last known whereabouts of a missing individual. Though the collagen component of bone is known to emit fluorescent, this property has not been leveraged consistently during skeletal remains searches. Thirty-six mock searches were completed in 5000 ft² zones of eastern deciduous forest by volunteers associated with the Virginia Department of Emergency Management. Pig and deer bones were scattered and partially concealed under brush and leaf cover. Pairs of volunteers were allowed up to one hour …

Identifying Barriers: Analysis Of Federal Law Enforcement Social Media And Recruitment Efforts, Reena Desai, Edgar Greer, Meghan Waldron

Doctor of Education Capstones

The Federal Bureau of Investigation Richmond Field Office seeks to diversify their applicant pool. In an effort to provide information on how to meet this need, our doctoral team analyzed the social media sites of six federal law enforcement agencies to include: the Federal Bureau of Investigation- Headquarters, Federal Bureau of Investigation-Richmond Field Office, Alcohol Tobacco & Firearms, the Federal Bureau of Prisons, the Drug Enforcement Agency, and the United States Marshal Service. By examining a 60-day window of images and their associated text on X (formerly Twitter), Facebook, and Instagram accounts, we wanted to gain a stronger understanding of …

Belonging At A Historically White Institution: Understanding The Men Of Color Experience, Riley Cain Sisk, Tara J. Hefner, Kelsie N. Potter, Nicholas A. Williams

Doctor of Education Capstones

Sense of belonging is a vital need that supports an individual’s journey of becoming. Studies have shown the positive impact sense of belonging can have on education outcomes, especially for underrepresented communities. Consulting with the Assessment Office in the Division of Student Affairs (The DSA Assessment Office) at Virginia Commonwealth University (VCU), the research team sought to understand how men of color make sense of belonging at historically white institutions (HWIs) such as VCU. This qualitative, instrumental case study utilized a subjectivist approach grounded in Strayhorn’s (2019) definition of ‘sense of belonging’ paired with Baxter Magolda’s (2014) theories of self-authorship. …

A Path Toward Healing: Parent And Caregiver Perspectives On The Work Of Restorative Practices Richmond At Martin Luther King, Jr. Middle School, Jean Samuel, Silvanus Thrower, Jill Flynn, Brandi Daniels

Doctor of Education Capstones

To address how key stakeholders experience restorative practices (RP), Restorative Practices Richmond (RPR) submitted a request for assistance (RFA) to Virginia Commonwealth University. This single case study responds to the RFA by examining how parents, caregivers, and community partners perceive school discipline and restorative practices and how this understanding supports RPR’s work to support restorative practices at Martin Luther King Middle School (MLK MS). Through a social justice lens, this capstone explores the challenges and needs of parents, caregivers, and community partners engaging with restorative practices. The findings that emerged included the following: parents and caregivers lack sufficient knowledge about …

Leveraging Leadership To Retain Early Career Teachers In Stafford County Public Schools, Christopher Gannon, Caroline Canning, Andrew Hoyt, Lauren Johnson, Thomas Mcauley

Doctor of Education Capstones

Stafford County Public Schools requested an evaluation of their current support of Early Career Teachers (ECTs) with one to three years experience, and its potential impact on retention efforts. They stamped this request with urgency, noting the COVID-19 pandemic and teacher pay as two driving factors, specifically, impacting retention of teachers within their first three years. Our Capstone team sought a deeper understanding of the following issues in three research questions: 1) types of support across their division and within their school buildings, 2) the impact of current practices of support, and 3) division-wide considerations for enhancing current systems of …

Riverview Community Park Commoning Plan, Haley B. Keene

Master of Urban and Regional Planning Capstone Projects

Riverview Community Park began as an illegal DIY skatepark in the Maymont neighborhood of Richmond, Virginia. Now, although it is a city park, it is still entirely managed by volunteer community groups (skateboarders, the neighborhood Civic League, and a community garden) who view the park as a creative, experimental community-led spatial project. Due to a dearth of communication between the three groups, the park has suffered political strife between the groups and a chaotic physical atmosphere. This plan utilizes a commons governance framework and participatory, asset-based community design to usher in a new era of enhanced collaboration, common narratives, and …