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Contributors Jan 1966

Contributors

MCV/Q, Medical College of Virginia Quarterly

List of contributors to this issue includes Marvin J. Allison, John D. Bower, Jack D. Burke, Alistair Cooke, Joseph T. Doyle, Enrique Gerszten, Carl Goldsmith, Thomas M. Harris, Robert J. Huebner, S. James Kilpatrick, Jr., Richard H. Kirkland, Eugene L. Klingler, Jr., Ruben G. Lancestremere, Joseph H. Magee, Kenneth Mullen, and Blanca Secades Sanchez.

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A Tissue Culture Perfusion Chamber With A Substratum Of Reconstituted Collagen, Thomas M. Harris Jan 1966

A Tissue Culture Perfusion Chamber With A Substratum Of Reconstituted Collagen, Thomas M. Harris

MCV/Q, Medical College of Virginia Quarterly

A tissue culture chamber is described that introduces the concept of a fixed platform within a "perfusion type" chamber. The platform is made of stainless steel mesh covered with a membrane of reconstituted collagen. The collagen membrane serves as the supporting substratum for the cultured tissue and is of such an optical quality as to permit phase-contrast microscopic observation of the tissue. The perfusion chamber is a Sykes-Moore tissue culture chamber modified to twice its normal depth to receive the screen. Cell growth in the experimental chamber is superior to growth in the control chamber both in speed of proliferation …

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Brains Of Prominent People: History, Facts And Significance, Walther Riese Jan 1966

Brains Of Prominent People: History, Facts And Significance, Walther Riese

MCV/Q, Medical College of Virginia Quarterly

In conclusion, in the brains of outstanding right-handed people (Haeckel, Monakow, Pilsudski) the more complicated convolutional and fissural patterns were found on the left hemisphere; in those of outstanding left-handed people (Menzel, Edinger) on the right one. The second brain reported here revealed some overdevelopments on the right, others on the left hemisphere. Strangely enough, very little is known about side-differences in the average brain. It seems that the middle frontal convolution and the inferior parietal lobe are more developed on the right hemisphere, the inferior frontal convolution on the left one. Nothing is known about the handedness of the …

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The Management Of Diabetes In Children, Thaddeus S. Danowski Jan 1966

The Management Of Diabetes In Children, Thaddeus S. Danowski

MCV/Q, Medical College of Virginia Quarterly

I think the time will come when we will all agree that diabetes mellitus is indeed the most common endocrinopathy, and that if we live long enough, at least 25% of the people in this room will develop diabetes. I believe that diabetes has manifestations both as a homozygous and heterozygous state, and that the heterozygous state or so-called carrier state become clinically manifest as we get older. Now I am not sure that such diabetes has the same significance as diabetes coming on earlier in life. It may be a benign type of diabetes, but at any rate, it …

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A Deadly Poison Becomes A Useful Tool, John W. Moore Jan 1966

A Deadly Poison Becomes A Useful Tool, John W. Moore

MCV/Q, Medical College of Virginia Quarterly

The very high potency of TTX and its highly selective block of nerve and skeletal muscle fibers has already shed a great deal of light on their excitation properties and should lead to the ability to specify an entirely new type of anesthetic agent even if the toxin itself does not also turn out to be useful agent in this respect.

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Ambulatory Services In Teaching Hospitals, Gabriel Hilkovitz Jan 1966

Ambulatory Services In Teaching Hospitals, Gabriel Hilkovitz

MCV/Q, Medical College of Virginia Quarterly

The outpatient clinics and emergency rooms of metropolitan teaching hospitals have been criticized severely in recent years for providing poor patient care. In most teaching hospitals the ratio between outpatients and inpatients is three to one; therefore, if the critics are right, 75% of the patients who obtain medical care at the teaching hospital, are not getting the best that medicine has to offer today.

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A Ranking Test In The Biological Sciences, Kenneth Mullen Jan 1966

A Ranking Test In The Biological Sciences, Kenneth Mullen

MCV/Q, Medical College of Virginia Quarterly

Laboratory analyses of biological materials are ranked in order of magnitude and summed across materials to give a list of laboratory scores. Under the assumed hypothesis that there is in fact no difference between laboratories, Monte-Carlo techniques are used to establish two-tailed 5% rejection limits for various combinations of laboratories and materials. The hypothesis that there is no difference between laboratories is rejected if any laboratory's score lies outside the 5% limits. Suppose that one needs to run a group of tests on a particular set of materials (chemical or biological), using a number of different laboratories, and wishes to …

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Volume Two Table Of Contents Jan 1966

Volume Two Table Of Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Volume Two.

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Clinicopathological Conference: Painful Leg Mass In A 23-Year-Old Male, Gerald A. Gildersleeve, Saul Kay Jan 1966

Clinicopathological Conference: Painful Leg Mass In A 23-Year-Old Male, Gerald A. Gildersleeve, Saul Kay

MCV/Q, Medical College of Virginia Quarterly

Report based on a clinicopathlogical conference transcript from the Medical College of Virginia regarding a painful leg mass in a 23 year-old male. Discussants include Gerald A. Gildersleeve and Saul Kay.

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Applications Of Computers To Medicine, Edward N. Brandt Jr. Jan 1966

Applications Of Computers To Medicine, Edward N. Brandt Jr.

MCV/Q, Medical College of Virginia Quarterly

The purpose of this paper is to present an over-view of current applications of computers to problems in medicine and not to discuss any specific application in detail. This discussion will be concerned only with digital computers. The modern digital computer is not very old. As a matter of fact, digital computers as we know them date from approximately 1949. Yet in this short span of time they have contributed to almost every sphere of man's activities. Computers have been applied to medical problems since about 1956, and have played an important role in increasing both the depth and breadth …

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A Simple Rapid Method For Determining Oxyhemoglobin Affinity: Illustration Using Blood From The Rhesus Monkey, Jack D. Burke Jan 1966

A Simple Rapid Method For Determining Oxyhemoglobin Affinity: Illustration Using Blood From The Rhesus Monkey, Jack D. Burke

MCV/Q, Medical College of Virginia Quarterly

Blood was obtained by cardiac puncture from the Rhesus monkey (Macaca mulatta). Hemolysates were prepared by filtration and centrifugation at 20,000 X g at 4 C. Oxyhemoglobin affinity curves were determined by a simplified spectrophotometric procedure on hemolysates diluted with phosphate buffers at pH of 7.4 and 6.8, and at an ionic strength of 0.3. The spectrophotometric readings were made at a wavelength of 640mμ and at a temperature of 23 C. The oxygen pressure at one-half saturation (P₅₀) for Rhesus homoglobin at a pH of 7.4 was 15 mm Hg, and at the more acid pH of 6.8, 23 …

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Diabetic Glomerulosclerosis, J. M. B. Bloodworth Jr. Jan 1966

Diabetic Glomerulosclerosis, J. M. B. Bloodworth Jr.

MCV/Q, Medical College of Virginia Quarterly

Why should the mesangial cells be irritated? We recently observed in some diabetics black deposits beneath and on both sides of the basement membrane. These appear quite similar to deposits seen in and around the basement membrane in glomerulonephritis and in lupus nephritis. I do not know for sure what they are, but theory says that in glomerulonephritis they probably represent antigen-antibody complexes. There is some evidence to support this. One would assume that in diabetes they might be the same thing. Or they might be some other atypical plasma protein which results from the abnormal pattern of diabetic metabolism. …

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Treatment Of Diabetes With Oral Hypoglycemic Drugs, James M. Moss Jan 1966

Treatment Of Diabetes With Oral Hypoglycemic Drugs, James M. Moss

MCV/Q, Medical College of Virginia Quarterly

Oral hypoglycemic drugs now available are of two types. The biguanides, of which phenformin (DBI) is the only one available, increase glucose utilization by muscles. The sulfonylureas, tolbutamide (Orinase), acetohexamide (Dymelor), and chlorpropamide (Diabinese), stimulate the pancreas to produce and release more insulin. All three sulfonylureas have the same effect in responsive patients, but they differ in potency and in duration of action.

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Volume Two Subject Index Jan 1966

Volume Two Subject Index

MCV/Q, Medical College of Virginia Quarterly

Subject index for MCV/Q, Medical College of Virginia Quarterly, Volume Two.

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The Healing Of Persons, Paul Tournier Jan 1966

The Healing Of Persons, Paul Tournier

MCV/Q, Medical College of Virginia Quarterly

Text of a talk delivered, in French, by Paul Tournier, at the Medical College of Virginia, April 27, 1965. Translation by Miss Beryl Eeman.

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The Shame Of American Medicine, Elinor Langer Jan 1966

The Shame Of American Medicine, Elinor Langer

MCV/Q, Medical College of Virginia Quarterly

The success of American medicine is often attributed to the profession's ability to serve the public on its own terms. Why should doctors care if, from the patient's point of view, the terms chosen--solo practice and emphasis on the "doctor-patient relationship"--mean that a doctor performs unsupervised services for unregulated fees? What does it matter to them that the poor are outside the system altogether, treated in charity wards or public hospitals which are the medical equivalent of Andrew Carnegie's libraries, a small concession to charity from an accelerating machine of wealth, power, and influence? In a country proud of its …

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"Slow" And "Fast" Muscle Fibers, Ernest Gutmann Jan 1966

"Slow" And "Fast" Muscle Fibers, Ernest Gutmann

MCV/Q, Medical College of Virginia Quarterly

On the basis of the clear-cut differentiation used in fast (twitch) and slow (tonic) muscles of the frog, both the fast E.D.L. and the slow soleus muscle should be considered twitch muscles. However, they reveal a marked differential behavior in their contracture responses to ACh and caffeine. Moreover, all the slow muscles I have studied (i.e.. the L.D.A. of the chicken, the rectus abdominis of the frog, and the soleus of the rat) show a higher rate of proteosynthesis. This may be related to the basic function of slow muscles concerned with long-lasting maintenance of tension, the extreme being, for …

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Contents Jan 1966

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Spring 1966, Volume Two, Number One.

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Plasma Volume Expansion And Proximal Tubular Reabsorption Of Salt And Water By Rat Kidney, Sidney Solomon, Harald Sonnenberg Jan 1966

Plasma Volume Expansion And Proximal Tubular Reabsorption Of Salt And Water By Rat Kidney, Sidney Solomon, Harald Sonnenberg

MCV/Q, Medical College of Virginia Quarterly

Venous infusion of both hypertonic and isotonic solutions has been known to lead to diuresis and natriuresis. In recent micropuncture studies, attempts have been made to identify the tubular locus at which renal functions may be altered and to identify the mechanism by which functional changes are mediated. In the rat, Giebisch et al. (1964) found suppressed fractional reabsorption of sodium at the level of the distal tubule when hypertonic saline was administered, whereas suppressed proximal fractional reabsorption was found only when excreted sodium was greater than 13% of the filtered load. On the other hand, Cortney et al. (1965) …

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Contents Jan 1966

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Winter 1966, Volume Two, Number Four.

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Medicovan (1968-03) Jan 1966

Medicovan (1968-03)

The Medicovan, 1948-1973

Published by: Medical College of Virginia, Feb. 1948-Aug. 1972; Virginia Commonwealth University, Sept. 1972-Feb. 1973.

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Determination Of Leukoagglutinin Specificity By In Vivo And In Vitro Studies, Ali A. Hossaini, Henry E. Wilson Jan 1966

Determination Of Leukoagglutinin Specificity By In Vivo And In Vitro Studies, Ali A. Hossaini, Henry E. Wilson

MCV/Q, Medical College of Virginia Quarterly

Results of testing sera from normal individuals and pathological patients, using a bromelin technique for the detection of leukoagglutinins, are reported. These results, supported further by an in vivo experiment, suggested that the phenomenon of leukoagglutination is immunologic in nature and that leukoagglutinins may be the cause of some febrile transfusion reactions. These are specifically directed against leukocytes, and do not involve the red cell series. Furthermore, the antigen (or antigens) is probably present in both the granulocytes and the mononuclear leukocytes. Anti-platelet antibodies could be presumed to be the cause of thrombocytopenia.

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Books Jan 1966

Books

MCV/Q, Medical College of Virginia Quarterly

Reviews of the following books: Ocular Syndromes, Walter J. Geeraets; Physiology and Biophysics of the Circulation, Alan C Burton; and Physiology of Respiration, Julius H. Comroe, Jr.

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Diabetic Microangiopathy, J. M. B. Bloodworth Jr. Jan 1966

Diabetic Microangiopathy, J. M. B. Bloodworth Jr.

MCV/Q, Medical College of Virginia Quarterly

Microangiopathy is the term applied to the abnormal state of the capillaries, arterioles, and venules found in the diabetic patient. It is characterized principally by thickening of the basement membrane of these small vessels. It might be worth mentioning that while we are concerned here with the smaller blood vessels, diabetic patients also show thickening of the basement membrane beneath the endothelium of arteries of all sizes. Also, the basement membrane-like material that surrounds each smooth muscle fiber in the wall of arteries shows similar thickening in diabetic patients. With this thickening, there is an increased glycoprotein content of the …

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Contributors Jan 1966

Contributors

MCV/Q, Medical College of Virginia Quarterly

List of contributors to this issue includes J. M. B. Bloodworth, Jr., Guy H. Chan, William F. Collins, Jr., Thaddeus S. Danowski, Max Ellenberg, Clay T. Gardner, Jr., David M. Hume, William R. Jordan, James M. Moss, John A. Owen, Jr., Olof H. Pearson, Thaddeus E. Prout, and H. St. George Tucker, Jr.

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Ernst Fischer: Thirty Years Of Service At The Medical College Of Virginia, Ernst G. Huf Jan 1966

Ernst Fischer: Thirty Years Of Service At The Medical College Of Virginia, Ernst G. Huf

MCV/Q, Medical College of Virginia Quarterly

Dedication essay by Ernst Huf to Dr. Ernst Fischer, who recently retired after thirty years of service to the Medical College of Virginia.

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Dynamic Physical Fitness And Body Composition, Archibald W. Sloan Jan 1966

Dynamic Physical Fitness And Body Composition, Archibald W. Sloan

MCV/Q, Medical College of Virginia Quarterly

Dynamic physical fitness may be satisfactorily estimated by the Harvard step test (modified for women) and this and other aspects of physical fitness are measured by appropriate test batteries. The percentage by weight of fat in the body may be calculated from the specific gravity or from caliper measurements of skin folds or ultrasonic measurements of the thickness of the layer of subcutaneous fat at selected sites. In general, physical education students are fitter than non-athletic students. British men students of physical education are fitter than American. International differences are less marked in non-athletic men and in women. Performance of …

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The Shame Of American Medicine--A Reply, David W. Richardson Jan 1966

The Shame Of American Medicine--A Reply, David W. Richardson

MCV/Q, Medical College of Virginia Quarterly

Reply to Elinor Langer's "The Shame of American Medicine" by David W. Richardson, M.D., Associate Professor of Medicine, Medical College of Virginia.

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Contributors Jan 1966

Contributors

MCV/Q, Medical College of Virginia Quarterly

List of contributors to this issue includes Rama M. Aiyawar, Hermann K. F. Blaschko, Ernest Bueding, Addison D. Campbell, Chalmers L. Gemmill, Ernest Gutmann, Gabriel Hilkovitz, Ernst G. Huf, Elinor Langer, Nancy S. LaPrade, John W. Moore, Richard W. Ramsey, Walther Riese, J. C. Rüegg, Alexander Sandow, Michael N. Sheridan, Archibald W. Sloan, Thomas C. Smith, Sidney Solomon, Harald Sonnenberg, Frederick J. Spencer, Sibyl F. Street, Alfred J. Szumski, William R. Tolbert, Hans H. Weber, and Priscilla M. Winn.

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Contents Jan 1966

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Fall 1966, Volume Two, Number Three.

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