Digital Commons Network^™

Initial Injury Type And Violent Reinjury, Nicholas Szoko, Daphne Lew, Taylor Kaser, Zoe M Miller, Matt Vogel, Michael A Mancini, Lindsay M Kranker, Christopher Behr, Vicki Moran, Rachel Ancona, Kristen Mueller

2020-Current year OA Pubs

IMPORTANCE: Violent injuries are the leading cause of death among children and young adults in the United States. Violent injury may increase the risk of subsequent injury (ie, violent reinjury), but it is unclear how this risk varies across different injury types (eg, blunt assault, stabbing, firearm).

OBJECTIVE: To describe patterns of violent reinjury across different injury types to inform tailored prevention strategies.

DESIGN, SETTING, AND PARTICIPANTS: This multicenter cohort study included patients who presented with violent injuries to 2 adult and 2 pediatric level I trauma centers in St Louis, Missouri, from January 2016 to December 2023.

EXPOSURES: Violent …

Chronic Conditions And Mortality In Medicare Beneficiaries Before And After The Covid-19 Pandemic, R J Waken, Fengxian Wang, Jose F Figueroa, Rishi K Wadhera, Khavya Avula, E John Orav, Anne Mobley Butler, Karen E Joynt Maddox

2020-Current year OA Pubs

IMPORTANCE: There were well-documented changes in health care use during the COVID-19 pandemic. Little is known about whether there were any associated decreases in claims-based comorbidity ascertainment that might have relevance to health services and policy research.

OBJECTIVE: To quantify differences in claims-based comorbidity assessment in Medicare beneficiaries pre- vs post-COVID-19.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study analyzed data from the 30 Chronic Conditions Warehouse 1- or 2-year lookback claims algorithms to ascertain each comorbidity with exact date ranges for all fee-for-service (FFS) and Medicare Advantage (MA) beneficiaries. Data were analyzed from April 2025 to April 2026.

EXPOSURES: The …

Understanding And Overcoming Innate And Acquired Mapk Inhibition Resistance In Anaplastic Thyroid Cancer, Peter Y F Zeng, Jalna Meens, Amir Hossein Karimi, Harrison Pan, Matthew J. Cecchini, Laura Jarycki, Sarah B. Ryan, Alice E. Dawson, Mushfiq H. Shaikh, David A. Palma

School of Medicine Publications

Anaplastic thyroid cancer (ATC) is highly lethal. Although patients with the BRAFV600E alteration respond to the type I RAF inhibitor (RAFi) dabrafenib with trametinib, most rapidly develop adaptive or acquired resistance. Here, multi-region whole-genome, high-coverage whole-exome, and single-nuclei RNA sequencing of tumors from ATC patients undergoing type I RAFi and MEKi therapy reveals that reactivation of the mitogen-activated protein kinase (MAPK) pathway, along with immunosuppressive macrophage proliferation, may underlie the development of acquired resistance. Screening of several RAFi reveals that ATC cell lines are exquisitely sensitive to the type II RAFi naporafenib, which inhibits EphA2-mediated MAPK signaling. Further, naporafenib and …

Strategies For Extending The Service Life Of Prestressed Concrete I-Shaped Beams, Sanjoy Kumar Bhowmik

Dissertations

Prestressed concrete (PSC) I-shaped beams are widely used in bridge construction because of their structural efficiency and durability. The service life of these beams is reduced and the maintenance frequency is increased due to the distress during fabrication and subsequent deterioration. Although several mitigation strategies have been proposed and implemented, beam end cracking during fabrication remains a major concern. The causes and mitigation strategies for beam end cracking have been studied for decades, but there have been no comprehensive studies utilizing beam end strains during fabrication and lifting at prefabrication plants under normal operational conditions. Moreover, existing maintenance and repair …

An Attachment Perspective For Help-Seeking Intentions Among Emerging Adult Women Child Sexual Abuse Survivors, Dominique Giroux

Dissertations

Child sexual abuse (CSA) is an adverse childhood experience and a global health issue. Approximately one in four girls encounter CSA per year. Research evidence suggests approximately 50% of CSA survivors encounter sexual revictimization during adulthood (Walker & Wamser-Nanney, 2023), but formal help and intervention can mitigate further psychosocial harm experienced by CSA survivors (Widom et al., 2008). Attachment theory has provided a theoretical framework for identifying individuals at risk for revictimization and help-seeking patterns, such that individuals who have insecure attachment styles report more revictimization frequency, but the literature is mixed about attachment styles and help-seeking (Brenner et al., …

Deployment-Aware Deep Learning For Computer Vision: Efficient Architectures From 3d Segmentation To Mixed Reality, Bahar Uddin Mahmud

Dissertations

Deep learning has become the dominant approach for solving vision-centric problems; however, its successful deployment in real-world applications remains limited by high computational cost, data dependency, and insufficient integration with practical and human-centered environments. While state-of-the art deep learning models often achieve impressive performance in controlled settings, they frequently fail to generalize or operate efficiently under deployment constraints such as limited resources, complex data modalities, and real-time interaction requirements. These limitations motivate the need for a deployment-oriented deep learning framework that balances accuracy, efficiency, and practical usability.

This dissertation investigates the design and deployment of efficient deep learning architectures for …

Design Of Advanced Water Purification System For The City Of Palo Alto, Kailee Oyama, Alex Marquez

Civil, Environmental and Sustainable Engineering Senior Theses

The Advanced Water Purification System (AWPS) is designed with multiple treatment units to facilitate potable water reuse of the effluent from the Wastewater Treatment Plant (WWTP) in Palo Alto. The membrane filtration process as well as post treatment conditioning results in a high quality recycled water that has a lower salinity concentration. The membrane filtration process separates the suspended particles such as bacteria, protozoa, and viruses from the WWTP effluent as well as reducing the dissolved solids, salts, smaller organic molecules, and trace contaminants by 90-99%. Then, the air stripping tower removes the excess carbon dioxide increasing the pH from …

Nanosilica-Enhanced Concrete For Commercial Construction, Pavlik Gribanovsky, Angel Lozano, Sebastian Rico

Civil, Environmental and Sustainable Engineering Senior Theses

Concrete is the most widely used construction material in the world. In consequence, the production of Portland cement contributes significantly to global carbon dioxide emissions. As the construction industry seeks more sustainable materials, nanosilica emerges as a promising material capable of enhancing the performance of concrete which would in turn reduce the demand of cement. This project investigated the feasibility of using laboratory-synthesized nanosilica as a concrete admixture to improve the mechanical performance of self-consolidating concrete. Concrete specimens were prepared in accordance with applicable ACI and ASTM procedures, cast into cylindrical molds, cured, and tested for compressive strength at seven …

The Effect Of Positive Communication On Leadership Development: A Qualitative Phenomenological Study, Philip J. Lowe

Electronic Theses and Dissertations

This qualitative phenomenological study explores the lived experiences of Christian college professors in the Midwest who utilize positive communication within mentoring relationships to develop leadership capabilities in students preparing for ministry. The research addresses the development of leadership capabilities in Christian colleges and examines how mentoring relationships serve as a sustainable alternative to costly and often ineffective formal programs. Following a descriptive phenomenological approach informed by the methods of Husserl and Giorgi, the researcher conducted semi-structured interviews with faculty members who have at least five years of teaching experience at a Christian college in the Midwest. The study utilized Bowlby’s …

African American Business Owners' Descriptions Of Experiences With Lending Practices, Wannika R. Muhammad

Electronic Theses and Dissertations

Entrepreneurship has remained an influential and unfulfilled goal for African Americans from the 1800s until now. Due to barriers in lending practices, increased business retention rates for African American business owners still need to be achieved. The lack of credit and lending resources hinders business growth and retention. Although Black-owned firms contribute significantly to the U.S. economy, they remain classified as underutilized entities that benefit the least, without adequate access to financial services, such as banking and lending opportunities. This study’s participants consisted of 12–15 African American business owners in central Texas, through a qualitative descriptive exploration of their experiences …

Isolation And Self-Efficacy Among Texas Educators With Disabilities Post-Covid: A Narrative Inquiry, Paul M. Nimon

Electronic Theses and Dissertations

The purpose of this qualitative inquiry was to explore the narratives of 10 current Texas public school educators with disabilities, as defined by the Americans with Disabilities Act, to understand how these narratives shaped their perceptions of burnout in relation to isolation and self-efficacy in the aftermath of the COVID-19 pandemic. The specific problem addressed the systemic, cultural, and interpersonal barriers that contribute to emotional exhaustion and professional marginalization for this population. The paradigm used was action research. The specific research methodology was a qualitative narrative inquiry. Data collection methods included 60-to-90-minute semistructured interviews conducted via Zoom and transcribed for …

Happycal: Designing Text And Image-Based Supports For Savouring Positive Work Experiences, Molly Stewart, Minghao Cai, Anthony Tang, Sam Liu, Chris Mosunic, Sowmya Somanath

Research Collection School Of Computing and Information Systems

Savouring positive work experiences can promote positive affect and well-being at work, yet there is limited guidance on how digital applications can support workers to engage in savouring. We developed HappyCal, a work-focused savouring application offering two forms of savouring support: text-based, a common modality in workplace reflection tools, and images, a largely unexplored approach in work-related savouring. We conducted an exploratory qualitative study where participants (N=36) used HappyCal over five days and engaged in savouring through either a text-only modality (n=17) or text input paired with image output (n=19). We found that (1) participants in both groups reported heightened …

“Alexa, Do Not Say That In Front Of My Boss!” A Cross-Cultural Comparison Of User And Ai Preferences For Privacy-Aware Smart Speaker Interactions Across Contexts, Lynne Warin, Emily Aurelia, Anthony Tang, Emily Aurelia, Delphine Reinhardt

Research Collection School Of Computing and Information Systems

Due to their limited ability to reason about the social context in which they are used, smart speakers pose significant privacy risks by responding in ways that may violate people's implicit social boundaries. We conducted a cross-cultural vignette study (N = 944) in Germany and Singapore to investigate how situational factors—specifically social context (bystander relationships and closeness), physical context (location), and interaction context (topic and deceptive intent)—regulate user preferences for smart speaker responses. Our results demonstrate that these factors are superior predictors of response preferences than dispositional user traits (i.e., intrinsic personal traits). We identify two distinct social dynamics: a …

Prevalence And Aetiology Of Cerebral Palsy Among Nigerian Children: A Systematic Review And Meta-Analysis., Udochukwu Michael Diala, Aderonke O. Uhunmwangho-Courage, Fatima Abdullahi, Paul Ikhurionan, Caitlin Bakker, Duke Appiah, David Danjuma Shwe, Rose N. Gelineau-Morel, Kabiru Gurama, Olugbenga Akinyemi Ofakunrin, Angela Mcgillivray, Gabriel E. Ofovwe, Tina Slusher

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Nigeria is among the leading countries contributing to the burden of cerebral palsy. Cerebral palsy (CP) is the commonest physical disability in childhood, accounting for 16.2% of child neurology referrals. Many cases of CP are preventable with simple interventions such as neonatal resuscitation and effective phototherapy. Lack of reliable data on the burden of disease limits comprehensive national policy directed to the prevention, holistic care and rehabilitation of patients with cerebral palsy in Nigeria. Therefore, to effectively address this problem, this study aimed to describe the pooled prevalence of CP in Nigeria, its potential causes and types.

METHODS: This …

Birth-Size Reference Charts For Newborns Admitted To The Neonatal Intensive Care Units., Fu-Sheng Chou, Hung-Wen Yeh, Crystal Hsueh, Irene E. Olsen, Veeral N. Tolia, Reese H. Clark

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Our original birth-size reference charts (the Olsen charts), published in 2010 (weight, length, head circumference) and 2015 (body mass index), had limitations, including manually defined exclusion criteria and the use of completed gestational weeks. This project aimed to update the charts and address those limitations.

METHODS: We analyzed de-identified data from infants admitted to Pediatrix NICUs between 2010 and 2022. In contrast to prior work, newborns with mortality before discharge, multiple births, and congenital anomalies were included; only statistical outliers (defined as two times the interquartile range below the first quartile or above the third quartile) were excluded. Gestational …

Worsened Multitasking Performance With Simulated Hearing Protection Correlates With Individuals' Choice Not To "Wear" It., Matthew G. Wisniewski, Patricia Mcclain, Chelsea N. Joyner

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Workers' reasons for not wearing hearing protection devices (HPDs) largely come from performance issues that occur while wearing. Research has shown that such complaints are justified in regard to auditory situational awareness (e.g., speech comprehension), but other aspects of work performance (e.g., multitasking ability) are rarely characterized. Further, the relationship between HPD-related performance worsening and the choice to wear an HPD has not been objectively characterized. We address both gaps in the literature here.

METHODS: Participants were presented with moving objects on a computer screen and tasked to track a "target" object by hovering a cursor over it. Target …

Infection Prevention And Control Of Candida Auris In Pediatric Settings, Thomas S. Murray, Hana Hakim, Christelle Ilboudo, Lynn Ramírez-Ávila, Jana Shaw, Terri Stillwell, Patricia Budo, Bernard Ebruke, Noa Fleiss, Amanda Green, Matthew Linam, Roshni Mathew, April Mcdougal, Natalie Neu, Zoi Dorothea Pana, Karen Ravin, Ayelet Rosenthal, Jane D. Siegel, Katlyn Steimel, Amy Valencia, Carol Vance, Lars F. Westblade, Lisa Saiman

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Candida auris (also referred to as Candidozyma auris) is an emerging multidrug-resistant fungal pathogen associated with high morbidity and mortality. Existing infection prevention and control (IPC) guidance has largely focused on adult populations, with limited recommendations for pediatric healthcare and non-healthcare settings.

METHODS: The Society for Healthcare Epidemiology of America (SHEA) convened a multidisciplinary expert panel to develop IPC recommendations for C. auris. The panel developed recommendations using a structured, iterative Delphi consensus process with rounds of discussion, refinement, and anonymous electronic voting with predefined consensus thresholds. Panelists reviewed relevant peer-reviewed and gray literature integrated with expert …

Spatial Clustering Of Recently Activated Cytotoxic Lymphocytes Improves Association With Overall Survival In Women With High-Grade Serous Ovarian Cancer., Alex C. Soupir, Mary K. Townsend, Cassandra A. Hathaway, Jonathan Nguyen, Carlos Moran Segura, Daryoush Saeed-Vafa, Oscar E. Ospina, Lauren C. Peres, Jose R. Conejo-Garcia, Kathryn L. Terry, Shelley S. Tworoger, Brooke L. Fridley

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: A previous study found that adding the spatial context of tumor-infiltrating lymphocytes (TIL) and cytotoxic T lymphocytes (CTL) to abundance improved associations with overall survival (OS) of non-Hispanic Black women with high-grade serous ovarian cancer (HGSOC). This study set out to replicate previous findings in predominantly non-Hispanic White women HGSOC cohorts.

METHODS: Multiplex immunofluorescence was used to characterize TILs in HGSOC from women enrolled in three epidemiologic studies (N = 433). Spatial clustering of TILs was derived using a permutation approach for Ripley K. Cox proportional hazards models were used for associations of spatial clustering and abundance with OS. …

Teaching Peace Where Borders Divide: Interdisciplinary Praxis In A Criminal Justice Program, Lucas Espinoza

Criminal Justice Faculty Publications

This article describes a criminal justice senior-level undergraduate course, CRIJ 4350: Peace, Nonviolence, & Justice, at a Hispanic-serving institution known as the University of Texas Rio Grande Valley, in the U.S.-Mexico borderlands. The course centers five key frameworks: critical pedagogy, intersectionality, decolonial theory, restorative and transformative justice, and trauma-informed care, as this course departs from carceral models of justice education. Grounded in theory, literature, and research from criminal justice, criminology, peace and conflict studies, sociology, political science, ethics/philosophy, social justice, human rights, and critical pedagogy, the course centers student reflection from course evaluations, relationships, and experiences of a faculty member. …

Long-Read Hifi Genome Sequencing Resolves Retrotransposon-Mediated Deletions In Tango2 Deficiency Disorder., Quentin Sabbagh, Felipe Villa Tobón, Zahra Kazemi, Laura Lentini, Marie-Emmanuelle Dilenge, Daniela Buhas, Tomi Pastinen, Isabelle Thiffault, Geneviève Bernard

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: TANGO2 deficiency disorder (TDD) is a rare autosomal recessive condition characterized by neurodevelopmental delay, epilepsy, and metabolic crises, mainly caused by recurrent deletions in

METHODS: Long-read HiFi GS was performed on blood-derived genomic DNA from affected individuals in both families using the Revio system (Pacific Biosciences).

RESULTS: Homozygous deletions spanning exons 3-9 in family 1 and exons 4-6 in family 2 were identified. These recurrent deletions resulted from genomic recombination between an Alu element and distinct retrotransposon subclasses: ERV1 in family 1 and L1MB8 in family 2. The lack of extended homology at breakpoint junctions, deletion sizes, and the …

Practice Patterns In Pediatric Cardiothoracic Presurgical Conferences: A Multicenter Survey Study., Britney Reed, Poonam Puranik, Andrew Rodenbarger, Mira Trivedi, Dilachew A. Adebo, Gary Beasley, Louis Bezold, M Jay Campbell, Michael R. Carr, Joshua Daily, Mark Debrunner, Erica Del Grippo, Carlen G. Fifer, Timothy M. Hoffman, Susan R. Hupp, Joshua D. Kurtz, Gira Morchi, Carl Owada, Renuka Peterson, Michael D. Puchalski, Ryan Romans, Arwa Saidi, Rajesh U. Shenoy, Anoop K. Singh, Robert D. Tunks, Thomas M. Yohannan, Carolyn M. Wilhelm, Jyoti K. Patel

Manuscripts, Articles, Book Chapters and Other Papers

Pediatric cardiothoracic surgeries are high-stakes, complex procedures, typically undergoing prior review at multidisciplinary conferences. This study evaluates practice patterns of conferences throughout the United States (US). Surveys were distributed to fellowship program directors or division directors in 124 US pediatric cardiology centers seeking information on conference logistics, fellow roles, quality improvement (QI), and satisfaction. All 47 responding centers (response rate 38%) conduct presurgical conferences, mostly on a weekly basis (92%) lasting 60-120 min (79%). The conferences are solely virtual (19%) or hybrid (81%). High-volume centers (> 300 surgical cases/year) are more likely to hold multiple conferences (13/20 vs 7/27, p <  0.01) and less likely to designate a moderator (11/20 vs 22/26, p = 0.027). Categorical pediatric cardiology fellows at 33 centers present clinical data (97%), echocardiograms (85%), catheterizations (82%), and cross-sectional imaging (39%), typically beginning in their first year. Most centers report that minor (98%) or major changes (51%) are made to patient management at least "sometimes." Responders rate conferences as very important (median 10/10 on a 10-point Likert scale, IQR 9-10), but satisfaction is more modest (median 7/10, IQR 7-9). Only 17% of centers have a formal QI process. Comments from 42 centers reveal positive themes of collaboration (68%) but also concerns about lengthy (30%) or inefficient (36%) discussion. Conclusions: This survey highlights common practices for pediatric cardiothoracic presurgical conferences. Conferences are collaborative and seen as highly impactful. However, satisfaction varies, and QI efforts are infrequent. These findings highlight opportunities for process improvement and standardization.

Strategies For High-Quality Community-Based Participatory Research Partnerships In Public Health Research., Emily M. D'Agostino, Rumour Piepenbrink, Lori Brand Bateman, Dana Keener Mast, Liliane Windsor, Debra Oto-Kent, Alan Wells, Jennifer Goldman, Jennifer E. Schuster, Rachel Kaufmann, Rachel Gurarie, Miriam Nuño

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: Community-Based Participatory Research (CBPR) is grounded in trusting, reciprocal, and authentic relationships. We aimed to identify key strategies and actionable next steps to establish and sustain high-quality community-academic partnerships that foster community-based health equity.

STUDY DESIGN: Qualitative thematic analysis.

METHODS: We analyzed three recorded discussions from a roundtable session with community and academic partners from the Rapid Acceleration of Diagnostics-Underserved Populations (RADx-UP) program (2020-2025), which supported 142 community-engaged public health research projects aimed at reducing COVID-19-related health inequities.

RESULTS: Key themes identified as most fundamental to support CBPR included establishing a long-term commitment, mutual co-learning among partners, flexible and …

Cover Story: The 2026 Mda Annual Session: Big Ideas Were Brewing!, David Foe

The Journal of the Michigan Dental Association

This article provides a comprehensive recap of the 2026 Michigan Dental Association Annual Session held at DeVos Place in Grand Rapids. Over 1,800 dental professionals gathered for three days of continuing education, keynote presentations, and professional networking. Significant highlights included the 40th anniversary of MDA Insurance and successful fundraising efforts for the MDA Foundation and Dental PAC. The event served as a final transition before the launch of The Great Lakes Dental Summit in 2027.

Attachment Style, The Working Alliance, And Client Self-Disclosure In Individual Psychotherapy, Jennifer S. Baar

Dissertations

Client self-disclosure is a core component of the psychotherapy process and increased levels of client self-disclosure have been shown to predict more positive therapeutic outcomes (Pattee & Farber, 2008; Sloan & Kahn, 2005). Similarly, the working alliance and attachment are constructs that have been studied in psychotherapy research and are consistently associated with therapeutic outcomes. Specifically, stronger working alliance ratings and higher levels of secure attachment have been found to predict more positive therapy outcomes (e.g., Flückiger et al., 2018; Mallinckrodt et al., 2005; Sauer et al., 2010). As these three constructs have been found to influence psychotherapy outcomes, the …

Exploring How Therapist Trainees’ Mentalization, Attachment Styles, And The Working Alliance Impact Treatment Outcomes In Psychotherapy, Hanali Gilbert

Dissertations

A burgeoning area of research within the past 30 years has sought to identify which specific therapist factors contribute to differential treatment outcomes (Barkham et al., 2017). The purpose of the current naturalistic study was to explore how two personal characteristics of therapist trainees, mentalization capacity and attachment styles, impact early treatment outcomes at two Midwestern psychology training clinics. This study also examined whether therapist mentalization and the working alliance interacted to influence client outcomes. Therapists completed the Mentalization Scale (MentS; Dimitrijević et al., 2018) and the Experiences in Close Relationships scale (ECR; Brennan et al., 1998), while the Working …

Personal And High-Intensity Gait Factors Associated With Balance And Walking Improvement With Outpatient Stroke Rehabilitation: A Retrospective Study, Heather Staal

Dissertations

Objective: The purpose of this study is to examine the relationships between personal factors and High-Intensity Gait variables and balance and walking improvement in an outpatient stroke population.

Background: Stroke is a leading cause of long-term disability, with persistent gait and balance impairments commonly limiting independence and participation. High-intensity gait training (HIGT) is an evidence-based rehabilitation approach that improves walking outcomes following stroke; however, guidance on how specific training variables are applied in outpatient physical therapy settings remains broad.

Methods: This retrospective observational study analyzes clinical data from outpatient physical therapy episodes in which HIGT is a …

Polygenic Risk Scores And Hla Class Ii Variants Are Biomarkers Of Corticosteroid Response In Childhood Nephrotic Syndrome., Tiffany Tu, Alejandro Ochoa, Amika Sood, Ashley Dabrik, Megan Chryst-Stangl, Brandon Lane, Guanghong Wu, Frank Donovan, Ursula Harper, Settara Chandrasekharappa, Christopher Esezobor, Adaobi Solarin, David Hooper, Christine Sethna, Sandra Amaral, Mahmoud Kallash, Michelle Rheault, Priya Verghese, Vikas Dharnidharka, Eloise Salmon, Patricia Weng, Tarak Srivastava, Michael E Seifert, Cozumel Pruette, David Selewski, Keisha Gibson, Tracy Hunley, Asiri Abeyagunawardena, Shenal Thalgahagoda, Arvind Bagga, Aditi Sinha, Nicholas Webb, Larry Greenbaum, Ali Gharavi, Krzysztof Kiryluk, Matthias Kretzler, Lisa Guay-Woodford, Simone Sanna-Cherchi, Agnieszka Bierzynska, Ania Koziell, Gavin Welsh, Moin Saleem, Charles Rotimi, Eileen Chambers, Cliburn Chan, Curegn Consortium, Pnrc Glomerular Disease Group, Cibmtr/Nmdp Consortium, Annette Jackson, Adebowale Adeyemo, Rasheed Gbadegesin

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there are no current reliable predictors of therapy response at initial clinical presentation.

METHODS: To evaluate predictors, we conducted genome-wide association studies, developed polygenic risk scores (PRS) for therapy response and analyzed classical HLA alleles in 1,997 children (994 discovery and 1,003 replication/validation cohorts) previously unstudied children with NS and 3,558 ancestry-matched control individuals.

RESULTS: A significant association with HLA loci defined by variants in HLA-DQB1, HLA-DRB1, and HLA-DQA1 were …

Early Neurodevelopmental Outcomes In Children With Congenital Heart Disease., Mike Seed, Dawn Ilardi, Valerie Rofeberg, Cynthia Ortinau, Caren Goldberg, Garrett Reichle, Lauren Bush, Justin Elhoff, Amy Jo Lisanti, Jennifer Butcher, Caitlin Rollins, Andrew Van Bergen, Shabnam Peyvandi, Emily Bucholz, Stephanie Cox, Lyla Hampton, Jacqueline Sanz, Sonia Monteiro, Shruti Tewar, Kiona Allen, Caroline Lee, Kristi Glotzbach, Nneka Alexander, Laurel Bear, Corinne Anton, Renee Sananes, Linh Ly, Gina Boucher, Kelly Wolfe, Lindsay Edwards, Elizabeth J. Willen, Alexander Tan, Christina Ortega, Erica Sood, Anjali Sadhwani, Kari Crawford Plant, Lauren Quigley, Jessica Pliego, Elizabeth Valles, Abbey Hines, David Wypij, Thomas Miller

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Neurodevelopmental impairments are common in children with congenital heart disease.

OBJECTIVES: To compare neurodevelopmental outcomes by cardiac diagnosis and identify associations between medical and social factors and early neurodevelopmental outcomes among children with congenital heart disease.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional analysis used neurodevelopmental follow-up data obtained between May 1, 2019, and June 30, 2022, and entered into the Cardiac Neurodevelopmental Outcome Collaborative (CNOC) registry, with linkage to the Pediatric Cardiac Critical Care Consortium registry. Children younger than 30 months from 25 CNOC sites were studied. Data analysis was performed between January 2023 and December 2024.

EXPOSURES: Patients …

Retrospective Chart Review Of Immobilized Lipase Cartridge Use In Children With Short Bowel Syndrome., Elizaveta Khenner, Jennifer Morton, Laura Green, Ashlee Yoder, Kayla Paul, Ann E. Remmers, William San Pablo

Manuscripts, Articles, Book Chapters and Other Papers

This retrospective, single-center chart review studied the use of an in-line, immobilized lipase cartridge (ILC) in children with short bowel syndrome (SBS) at Children's Mercy Hospital. For parenteral nutrition (PN)-dependent patients, the primary endpoint was enteral feeding progression, evaluated by comparing monthly change from baseline in PN and enteral nutrition (EN) after the start of ILC use. For patients with enteral autonomy, changes from baseline in growth measure z-scores were evaluated. In 9 PN-dependent patients (with Type II or III SBS), mean PN use decreased 10.6 kcal/kg/day (15.5%) and mean EN use increased by 6.0 kcal/kg/day (39.9%) after 3.8 to …

Incidental Colorectal Adenomas In Adolescents: Clinical Management, Genetic Evaluation, And Surveillance., Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard

Manuscripts, Articles, Book Chapters and Other Papers

The rising incidence of early-onset colorectal cancer has renewed attention to colorectal adenomas in adolescents and young adults (AYA), although these lesions remain rare and poorly characterized in adolescents. Lack of age-specific guidance creates uncertainty regarding genetic evaluation, surveillance intervals, and long-term management when these lesions are identified in adolescents. This narrative review synthesizes current evidence and expert perspective on epidemiology, evaluation, endoscopic management, surveillance, genetic considerations, and psychosocial implications of incidentally identified colorectal adenomas across the AYA spectrum, with emphasis on adolescents as a distinct clinical population. Available data largely derive from adults aged 20-49 years but suggest that …