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The Effects Of Bfgf Treatment In The Aged Brain Following Traumatic Brain Injury, Michael Zeigler Jun 2010

The Effects Of Bfgf Treatment In The Aged Brain Following Traumatic Brain Injury, Michael Zeigler

Theses and Dissertations

The mature mammalian brain continually generates new neurons in the subventricular zone and hippocampus throughout life. Adult neurogenesis in the hippocampus is associated with hippocampal-dependent learning and memory function. During aging, this endogenous neurogenic potential is reduced which is accompanied by decreased cognitive function seen in the aging population. We have previously found that the injured adult brain shows heightened levels of endogenous neurogenesis and this response is associated with innate cognitive recovery. We have also found that basic fibroblast growth factor (bFGF), a potent neurotrophic polypeptide, can enhance injury-induced hippocampal neurogenesis and improve cognitive recovery following TBI. In this …

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The Design Integration Of An Animal Shelter Into Martin Luther King Middle School, Anna Givens May 2010

The Design Integration Of An Animal Shelter Into Martin Luther King Middle School, Anna Givens

Theses and Dissertations

This thesis explores the design integration of an animal shelter into an existing school in an at-risk neighborhood. The connection between at-risk students and homeless animals is valuable to the design. A large central courtyard located within Martin Luther King Middle School serves as a connection between both students and animals. Because the animal shelter is located in a central location within the school, students and animals have a greater ability to form a connection necessary for the program to work. This thesis is about the interaction between both animals and students through the process of design.

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A Case Study Of Network Design For Middle East Water Distribution, Rachel Bullene May 2010

A Case Study Of Network Design For Middle East Water Distribution, Rachel Bullene

Theses and Dissertations

The Middle Eastern region encompassing Israel, Jordan, and the Palestinian Territories (West Bank and Gaza) is an arid region with fast growing populations. Adequate and equitable access to water for all the people of the region is crucial to the future of Middle East peace. However, the current water distribution system not only fails to provide an adequate and equitable allocation of water, but also results adverse impacts on the environment. This project involves building a mathematical model to aid decision-makers in designing an optimal water distribution network. A new method for incorporating uncertainty in optimization that is based on …

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The Lived Experience Of Faith Community Nurses Living The Call To Health Ministry, Deborah Mobley May 2010

The Lived Experience Of Faith Community Nurses Living The Call To Health Ministry, Deborah Mobley

Theses and Dissertations

Faith community nursing is one of the newest specialized practices of professional nursing. A faith community nurse is an actively registered professional nurse, who serves as a paid or volunteer staff member in a faith community. The faith community nurse promotes health and wholism of the faith community, its groups, families, and individual members. A faith community, as in a church, synagogue or mosque, is an organization of individuals and families who share common beliefs, values, religious doctrine, and faith practices that influence their lives. The faith community functions as a client system for the faith community nurse. The purpose …

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Signaling Pathways Coupled To Melatonin Receptor Mt1 In Gastric Smooth Muscle, Rashad Ahmed May 2010

Signaling Pathways Coupled To Melatonin Receptor Mt1 In Gastric Smooth Muscle, Rashad Ahmed

Theses and Dissertations

The Melatonin, a close derivative of serotonin, is involved in physiological regulation of circadian rhythms. In the gastrointestinal (GI) system, melatonin exhibits endocrine, paracrine and autocrine actions and is implicated in the regulation of GI motility. Generally, melatonin actions oppose the stimulatory actions of serotonin on motility. However, it is not known whether melatonin can also act directly on GI smooth muscle cells. The aim of the present study was to determine the expression of melatonin receptors in smooth muscle and identify their signaling pathways. Muscle cells were isolated from rabbit distal stomach by enzymatic digestion, filtration and centrifugation and …

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The Clinical Utility Of Cardiopulmonary Exercise Testing In Patients With Suspected Myocardial Ischemia, Sherry Pinkstaff May 2010

The Clinical Utility Of Cardiopulmonary Exercise Testing In Patients With Suspected Myocardial Ischemia, Sherry Pinkstaff

Theses and Dissertations

Heart disease is a major cause of morbidity and mortality in the United States with coronary artery disease (CAD) representing more than half of all cardiovascular events. Stable patients presenting with symptoms suggestive of CAD are likely to undergo either an exercise ECG and/or imaging study as a first line diagnostic assessment. A cardiopulmonary exercise test (CPX) is an ECG stress test plus ventilatory gas analysis. Recently CPX has been used to detect exercise-induced myocardial ischemia suggestive of underlying CAD. Currently there are a number of diagnostic tests available for the identification of CAD with the most widely used being …

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Opioid Addiction And Pregnancy: Potential Effects Of Substitution Therapies On Developmental Myelination, Andrew Eschenroeder May 2010

Opioid Addiction And Pregnancy: Potential Effects Of Substitution Therapies On Developmental Myelination, Andrew Eschenroeder

Theses and Dissertations

While most cells of the central nervous system (CNS) express opioid receptors, the role of the endogenous opioid system in CNS development remains poorly understood. Identification of opioid functions during brain maturation is particularly crucial in light of the increasing trend in opioid abuse and the use of opioid drugs during pregnancy. New substitution therapies in pregnant opioid addicts include buprenorphine, a mu opioid receptor partial agonist and kappa opioid receptor antagonist. However, while clinical studies demonstrated buprenorphine efficacy in reducing neonatal withdrawal symptoms, there is a lack of information on the potential effects of this drug on brain development. …

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Identification And Characterization Of A Second Wolfram Syndrome Gene, Sami Amr May 2010

Identification And Characterization Of A Second Wolfram Syndrome Gene, Sami Amr

Theses and Dissertations

Wolfram Syndrome (WFS) is a debilitating autosomal recessive neurodegenerative disorder characterized by juvenile onset insulin dependent diabetes mellitus (DM) and optic atrophy (OA) as well as a number of neurological and endocrine complications that result in early death due to respiratory complications. Previous research has mapped Wolfram syndrome to chromosome 4p16.1 and the disease has been attributed to mutations in the WFS1 gene affecting the WFS1 protein (wolframin), an ER membrane glycoprotein that plays an important role in the unfolded protein response (UPR) and in intracellular Ca2+ homeostasis. An additional locus for WFS on chromosome 4q22-24 was identified by linkage …

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Graphic Design As Projection, Bret Hansen May 2010

Graphic Design As Projection, Bret Hansen

Theses and Dissertations

I imagined a world where designing is projecting and where the entire design field is called projection. My research into what it means to be a projector culminates in a participatory creative project that embodies concepts of projection taken from a range of disparate subjects.

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Duality And The Parallel Lives, Hiromi Takizawa May 2010

Duality And The Parallel Lives, Hiromi Takizawa

Theses and Dissertations

My engagement with making is a metaphor that contains the interior landscapes of my mind. I continue to explore it by comparing and contrasting exterior and interior, investigating surface and depth, covering and exposing, and taking apart and putting together. I work to translate my individual experiences and emotions into a tangible form. The visual dialogues that I engage in with my work explore a range of aspects that are inherent and specific to my Japanese cultural heritage. It often springs from my daily encounters with the subtle nuances and observable oddities of living in the “West”. These experiences have …

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An Indecent Obsession, Aaron Mcintosh May 2010

An Indecent Obsession, Aaron Mcintosh

Theses and Dissertations

The title of my thesis is appropriately borrowed from a romance novel title, as my work proposes to mine the content, design and culture of romance novels and other erotic texts in order to excavate my own queer romance narrative. The body of work includes large-scale drawings of “stand-in boyfriends” stolen from romance novel covers, pieced fabric text works based on the titles of erotic texts, and a couch covered in erotic reading material. Drawing attention to the ubiquity of heterosexualized images and texts by deconstructing them, my work critically questions larger social constructions of normality and deviance, pleasure and …

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A Behavioral Comparison Of Four Inbred Strains Of Mice, Erin Wood May 2010

A Behavioral Comparison Of Four Inbred Strains Of Mice, Erin Wood

Theses and Dissertations

Isogenic, or inbred, mouse strains are currently the experimental subjects of choice in laboratory studies focused on genetics, pharmacology, and psychological issues. Understanding phenotypic differences in isogenic strains is important in order to interpret experimental results obtained from inbred mouse strains. Four commonly used inbred strains, C57BL/6NHsd (C57), DBA/2NHsd (DBA), 129S2/SvHsd (129), and Balb/cAnHsd (Balb/c), are investigated in this study using four different behavioral tasks that measure locomotor activity and cognitive behavior (Morris Water Maze (MWM), T-maze, and operant autoshaping procedures). In the locomotor activity task 129 mice showed significantly less horizontal ambulation than any other strain, while differences in …

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Sweet Briar, 1800-1900: Palladian Plantation House, Italianate Villa, Aesthetic Retreat, Harriet Christian Carr May 2010

Sweet Briar, 1800-1900: Palladian Plantation House, Italianate Villa, Aesthetic Retreat, Harriet Christian Carr

Theses and Dissertations

Sweet Briar House is one of the best documented sites in Virginia, with sources ranging from architectural drawings and extensive archives to original furnishings. Sweet Briar House was purchased by Elijah Fletcher, a prominent figure in Lynchburg, Virginia, in 1830. Thirty years later it passed into the possession of his daughter Indiana Fletcher Williams, and remained her home until her death in 1900. In her will, Williams left instructions for the founding of Sweet Briar Institute, an educational institution for women that exists today as Sweet Briar College. This dissertation examines Sweet Briar House in three distinct phases, while advancing …

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Eternal September, Benjamin Jurgensen May 2010

Eternal September, Benjamin Jurgensen

Theses and Dissertations

A series of digitally inflected texts – September that never ends, some French belles, 1950/1986/1996, Ted Turner, being SO FUCKING FUTURE, The Gilmore Girls, Fic, FanFic, Sapphic, ctrl-c/v, “falsehood”, memes, Robert Gober, INTP, thought control, a “line of flight”, speed, and light refracting on all of it

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Effect Of Hyaluronidase Treatment On The Structural Integrity Of The Endothelial Glycocalyx Layer, Kristin Simmons May 2010

Effect Of Hyaluronidase Treatment On The Structural Integrity Of The Endothelial Glycocalyx Layer, Kristin Simmons

Theses and Dissertations

The endothelial glycocalyx plays an important role as part of the permeability barrier between the blood and the interstitium. In this study, we used different sized fluorescently labeled dextran molecules to determine the size of the macromolecular exclusion zone in capillaries. The width of the exclusion zone was calculated as one half the difference between the anatomic luminal diameter, as determined by transillumination, and the width of a fluorescent dextran column. During the first hour after systemic injection of labeled dextrans, neither 70 kDa dextran (Dextran 70) nor 500 kDa dextran (Dextran 500) labeled with the anionic fluorescein isothiocyanate (FITC) …

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Neuroprotective Effects Of Postinjury Lithium Treatment: Determining The Optimal Dosing Paradigm And Assessing Potential Mechanisms Of Action, Katharine Eakin May 2010

Neuroprotective Effects Of Postinjury Lithium Treatment: Determining The Optimal Dosing Paradigm And Assessing Potential Mechanisms Of Action, Katharine Eakin

Theses and Dissertations

Traumatic brain injury (TBI) has a dramatic impact on our society in terms of mortality, morbidity, and inherently high financial costs. Formidable research efforts are being addressed to the identification of neuroprotective agents capable of ameliorating the neurological outcome after TBI. Preclinical studies have recently demonstrated lithium to be a promising neuroprotective agent for both acute ischemic brain injury and chronic neurodegenerative disease. In light of these encouraging data, we designed a lateral fluid-percussion injury (FPI) study aimed at investigating the role of early post-traumatic administration of lithium as a strategy for reducing TBI-induced motor and cognitive deficits. The optimal …

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Awesome, Hannah Walsh May 2010

Awesome, Hannah Walsh

Theses and Dissertations

Opinions about Linguistics and Phonetics extrapolated to think about art and object-making, followed by an exposition of titles of recent work, including discussions about: stunting in All Star Cheerleading, rainbows, offset halo patterns, the common corn disease Crazy Top, failure, humility and the profound.

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Eighteen Hundred And Froze To Death, Cognets Nicholas Des May 2010

Eighteen Hundred And Froze To Death, Cognets Nicholas Des

Theses and Dissertations

Essay to accompany MFA thesis exhibition for the Department of Sculpture and Extended Media.

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A Computational Biology Approach To The Analysis Of Complex Physiology: Coagulation, Fibrinolysis, And Wound Healing, Nathan Menke May 2010

A Computational Biology Approach To The Analysis Of Complex Physiology: Coagulation, Fibrinolysis, And Wound Healing, Nathan Menke

Theses and Dissertations

The birth of complexity research derives from the logical progression of advancement in the scientific field afforded by reductionist theory. We present in silico models of two complex physiological processes, wound healing and coagulation/fibrinolysis based on two common tools in the study of complex physiology: ordinary differential equations (ODE) and Agent Based Modeling (ABM). The strengths of these two approaches are well-suited in the analysis of clinical paradigms such as wound healing and coagulation. The complex interactions that characterize acute wound healing have stymied the development of effective therapeutic modalities. The use of computational models holds the promise to improve …

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Domination In Benzenoids, Nisreen Bukhary May 2010

Domination In Benzenoids, Nisreen Bukhary

Theses and Dissertations

A benzenoid is a molecule that can be represented as a graph. This graph is a fragment of the hexagon lattice. A dominating set $D$ in a graph $G$ is a set of vertices such that each vertex of the graph is either in $D$ or adjacent to a vertex in $D$. The domination number $\gamma=\gamma(G)$ of a graph $G$ is the size of a minimum dominating set. We will find formulas and bounds for the domination number of various special benzenoids, namely, linear chains $L(h)$, triangulenes $T_k$, and parallelogram benzenoids $B_{p,q}$. The domination ratio of a graph $G$ is …

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Spinal Cord Injury: Exploring The Histology Of Electrospun Implants In Vivo, Charles Lin May 2010

Spinal Cord Injury: Exploring The Histology Of Electrospun Implants In Vivo, Charles Lin

Theses and Dissertations

Spinal cord injury results in loss of motor function and sensory perception. A myriad of obstacles prevent axonal regeneration and ultimately functional recovery in those afflicted with spinal cord injury. Combinatorial strategies addressing many of these obstacles simultaneously have shown promising results. Laboratories investigating contusional spinal cord injuries must overcome the formation of a fluid filled cyst, a physical gap that axons must traverse, at the injury epicenter. To fill the cyst, our lab has generated a 3-D electrospun matrix that is capable of directing neurite outgrowth, delivering neurotrophic support, and reducing the activity of neuroinhibitory compounds. These electrospun matrices …

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The Epidemiology Of Snakebite Injury In The Amazonian Regions Of Ecuador, Sarah Stuppy May 2010

The Epidemiology Of Snakebite Injury In The Amazonian Regions Of Ecuador, Sarah Stuppy

Theses and Dissertations

The epidemiology of snakebite injury in the Amazonian regions of Ecuador Introduction: Morbidity and mortality from snakebite envenomations is a major public health issue in remote areas of under-developed countries. Several attempts have been made to approximate the impact of snakebites worldwide, however these are assumed to be underestimations due to the lack of documentation on the local level. Ecuador's Amazonian region lacks a comprehensive community-based surveillance system, however it is unique in that an aero-medical transport system is in place to transfer the patients requiring hospitalization to one of the five urban medical centers. Beginning in 1998, Servicio Aéreo …

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A Novel Role Of Sirt1 In Sildenafil Induced Cardioprotection In Mice, Mona Shalwala May 2010

A Novel Role Of Sirt1 In Sildenafil Induced Cardioprotection In Mice, Mona Shalwala

Theses and Dissertations

Phosphodiesterase-5 inhibitor, sildenafil (SIL) protects against myocardial ischemia/reperfusion (I-R) injury. We hypothesized that SIL-induced protection may be mediated through activation of SIRT1, an enzyme which deacetylates proteins involved in cellular stress response. Adult male ICR mice were treated with SIL (0.7mg/kg ip), Resveratrol (RSV) (5mg/kg ip) (positive control), or saline (0.2 ml ip). The hearts were harvested 24 h later and homogenized for SIRT1 activity analysis. Both SIL and RSV increased cardiac SIRT1 activity (P<0.001) as compared to Saline. Adult mouse ventricular cardiomyocytes pre-treated with either SIL or RSV (1µM) in vitro also upregulated SIRT1 activity (P<0.05). SIL also reduced infarct size following 30 min. ischemia and 24 h reperfusion in vivo. Sirtinol (5mg/kg in 10% DMSO, ip), a SIRT1 inhibitor abolished the infarct-limiting effect of SIL and RSV (P<0.001). In conclusion, activation of SIRT1 by SIL plays an essential role in cardioprotection against I-R injury.

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Psycho Beach Party: A Vocal And Physical Exploration Of Gender, Megan Persinger May 2010

Psycho Beach Party: A Vocal And Physical Exploration Of Gender, Megan Persinger

Theses and Dissertations

On September 24, 2009, Theatre VCU opened its production of Psycho Beach Party, written by Charles Busch and directed by Steve Perigard. In our production, two male actors, Tommy Callan and Kyle Cornell, were cross-sex cast to play female characters, Chicklet and Marvel Ann respectively. In addition to serving as vocal coach for the production, I was to help Callan and Cornell vocally transform into female characters. I have documented our exploration of gender, specifically the vocal transformation from male to female, in Theatre VCU’s production of Psycho Beach Party. Neither actor had played a female character onstage before, and …

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For The Love Of God?! Is There A Place For Gay Christians Between Faith And Fundamentalism?, Apryl D. Prentiss May 2010

For The Love Of God?! Is There A Place For Gay Christians Between Faith And Fundamentalism?, Apryl D. Prentiss

Theses and Dissertations

Drawing from observation, autoethnography, ethnographic research and audio-taped interviews, this thesis explores the complicated and emotionally charged relationship between homosexuality and Christianity. The current culture war being waged in the media between the Religious Right and members of the LGBT community often results in the isolation and rejection of those who would define themselves as gay Christians. This thesis explores the role of the Bible as it informs and catalyzes this war and other foundational beliefs used as weapons in this rhetorical conflict. Additionally, this thesis analyzes the current battle between the church and the social movement for change in …

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Neutrophil Products Control The Expression Of Progesterone Receptors And Matrix Metalloproteinase-1 In The Decidual And Myometrium And Are Possible Regulators Of Premature Labor, Anna Solotskaya May 2010

Neutrophil Products Control The Expression Of Progesterone Receptors And Matrix Metalloproteinase-1 In The Decidual And Myometrium And Are Possible Regulators Of Premature Labor, Anna Solotskaya

Theses and Dissertations

Neutrophils infiltrate myometrium and decidual tissue prior to parturition. Activated neutrophils release reactive oxygen species (ROS) and tumor necrosis factor α (TNFα), which might increase expression of pro-labor genes such as matrix metalloproteinase-1 (MMP-1), progesterone receptor (PR) A/B ratio, and cause demethylation of DNA. These changes might cause labor. Decidual tissue was obtained from consented, healthy women at term (37+ weeks of gestation) not in labor (no contractions, without cervical effacement), term labor and preterm labor (under 37 weeks of pregnancy). Decidual and myometrial cells in culture were treated with (1) ROS, (2) TNFα, or (3) 5-aza-2’-deoxycytidine. Total RNA was …

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Commonwealth Times 2010-05-03 May 2010

Commonwealth Times 2010-05-03

Commonwealth Times, 1969-

No abstract provided.

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The Michael Chekhov Technique: In The Classroom And On Stage, Josh Chenard May 2010

The Michael Chekhov Technique: In The Classroom And On Stage, Josh Chenard

Theses and Dissertations

Referred to by Constantin Stanislavski as “My most brilliant pupil,” Michael Chekhov’s approach to acting is founded in an understanding of the artist as a whole being whose thoughts, feelings, desires, voice, and physical body are intimately interwoven. The Michael Chekhov technique trains these aspects jointly while encouraging the actor to fully explore and utilize his or her unlimited, rich, and fertile imagination. I have seen the powerful benefits of this technique as an actor (which I have been utilizing for 13 years) and as a teacher and director (for almost 10 years). In my thesis, I will firstly describe …

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Development And Implementation Of A Tissue Specific Microrna Prediction Tool For Identifying Targets Of The Tumor Suppressor Microrna 17-3p, William Budd Apr 2010

Development And Implementation Of A Tissue Specific Microrna Prediction Tool For Identifying Targets Of The Tumor Suppressor Microrna 17-3p, William Budd

Theses and Dissertations

A unique computational approach was undertaken to identify targets of miR-17-3p that impart an oncogenic potential to the cells of the prostate. Utilizing this approach, we identified insulin growth factor receptor 1 (IGF1R) as a potential target of miR-17-3p. IGF1R imparts an oncogenic approach to the cells by helping cells escape apoptosis, become hypertrophic and increase the production of extracellular proteases that allow cells to detach from neighbors. The regulation of insulin growth factor receptor 1 by human microRNA-17-3p was evaluated using a western blot analysis of prostate cancer cell lines. Protein levels were compared in a cell line that …

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Constructs: Truth, Lies, And Humanity, Nathan Hansen Apr 2010

Constructs: Truth, Lies, And Humanity, Nathan Hansen

Theses and Dissertations

This thesis is a discussion of my ideas, struggles and outcomes experienced during the making of my two bodies of work, Devices and Relics. These two bodies of work explore fleeting moments, the intrinsic values of labor and imagination with reference to sedentary living and labor in contemporary American society.

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