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L-Ergothioneine Shows Benefits In Reducing Age-Related Hearing Loss: Improved Signal-In-Noise Detection In Mice, Evin Roji, Muhammad Hassam Amir
L-Ergothioneine Shows Benefits In Reducing Age-Related Hearing Loss: Improved Signal-In-Noise Detection In Mice, Evin Roji, Muhammad Hassam Amir
OneUSF Undergraduate Research Conference
The amino acid, L-ergothioneine (EGT), has gained attention as a potential therapeutic for age-related conditions due to its antioxidant and antiinflammatory properties. EGT is naturally found in various foods and shows promise in protecting against oxidative stress, inflammation, and neurodegeneration. Recent studies have highlighted its role in improving physiological functions in aging models, particularly in mitigating age-related declines in sensory and neurological systems. In this study, we aimed to investigate whether long-term oral administration of EGT via gavage could improve hearing function in aged mice. Hearing sensitivity and signal-in-noise detection were measured to determine the therapeutic potential of EGT for …
Barry Jenkins' Moonlight: Reimagining The Coming-Of-Age Genre In Film, Jonathan R. Davis
Barry Jenkins' Moonlight: Reimagining The Coming-Of-Age Genre In Film, Jonathan R. Davis
OneUSF Undergraduate Research Conference
The coming-of-age genre in film was established during the 1950s, a postwar period defined by rebellious and confused teenagers. Within the film genre, the young protagonist experiences physical or emotional struggle throughout their expedition, resulting in organic identity discovery. One subdivision of the genre that emerged during the 1990s was black coming-of-age stories. However, it was not until Barry Jenkins’ 2016 film Moonlight that the genre was completely reimagined in a new light. Jenkins’ film does not follow the recurrent coming-of-age plotline that has been exemplified in previous films of the genre, which display youthful growth by the end. …
Replication Fork Remodeling Curtails Dna Synthesis During Excessive Origin Firing, Thanh Le
Replication Fork Remodeling Curtails Dna Synthesis During Excessive Origin Firing, Thanh Le
OneUSF Undergraduate Research Conference
DNA replication is a faithful and accurate process during S-phase in each cell division. Errors in replication can potentially lead to cancer, highlighting the purpose of studying mechanisms of DNA replication. There are many challenges that cause DNA damage, making replication fork regulation essential to protect genome integrity. When cell misregulate during replication, it can result in re-replication, which replication origins are re-licensed and fired again. This leads to stress induced DNA breaks, activating cell cycle checkpoints and apoptosis, which cancer cells try to evade, making it a potential chemotherapy target. While re-replication is a source of genomic instability, re-replication …
Parental Internalizing Symptoms And Parenting Behaviors: The Moderating Role Of Social Support, Anh Van Nguyen
Parental Internalizing Symptoms And Parenting Behaviors: The Moderating Role Of Social Support, Anh Van Nguyen
OneUSF Undergraduate Research Conference
“It takes a village to raise a child”. Social support is vital to parents in carrying out child-rearing duties, which is an additional source of stress for parents. Parents who exhibit higher levels of internalizing symptoms (e.g., depression, anxiety, stress) are more likely to engage in negative parenting behaviors. These behaviors can, in turn, negatively impact child development. Therefore, it is essential to investigate whether greater social support can buffer or attenuate the relationship between parental internalizing symptoms and negative parenting practices. Understanding this potential moderating effect is particularly important given the central role of parenting in shaping children’s developmental …
Evolutionary Conservation And The Role Of Foxp2 In Human Speech And Language Development, Keira N. Ballard
Evolutionary Conservation And The Role Of Foxp2 In Human Speech And Language Development, Keira N. Ballard
OneUSF Undergraduate Research Conference
The study of genes offers a crucial understanding in the evolution of species and the many abilities an organism may have, including language. The FOXP2 gene encodes for the protein forkhead box P2, a transcription factor that is active in the development of speech and language during embryogenesis. Several single-nucleotide polymorphisms of this gene in humans have been linked to the speech and language disorder, childhood apraxia of speech, further supporting the gene’s role in human speech and language. The FOXP2 gene is highly conserved across vertebrates, even in species with limited vocalizations. This is particularly true among humans, chimpanzees, …
Insights On Aapeptides As They Relate To Inhibiting The P300 Ch1 Domain, Tyler Lambert
Insights On Aapeptides As They Relate To Inhibiting The P300 Ch1 Domain, Tyler Lambert
OneUSF Undergraduate Research Conference
The HIF-1 pathway helps sustain cancerous tumors by preventing tumor cells from becoming necrotic. The histone acetyltransferase p300 protein is a vital coactivator used in the HIF-1 (hypoxia inducible factor) pathway by binding to subunit HIF-1a. Within our lab we aim to use novel AApeptides as a means of competitively inhibiting the p300 coactivator from binding to the HIF-1a subunit. In order to do this we are specifically studying the protein protein interactions of the CH1 (cysteine/histidine rich-1) domain of the p300 protein as it binds to the C-terminal transactivation domain of the HIF-1a subunit. The p300 CH1 domain is …
Evaluating Impact Of Congenital Zika Virus Infection On Reproductive Health And Neonatal Outcomes In Latin America, Adrianna Soto, Maria Ivanova, Amanda Chinea, Daniela Davila, Ana Laura Alcantara Nascimento, Michelle Rodriguez, Valerie Vargas Ardila
Evaluating Impact Of Congenital Zika Virus Infection On Reproductive Health And Neonatal Outcomes In Latin America, Adrianna Soto, Maria Ivanova, Amanda Chinea, Daniela Davila, Ana Laura Alcantara Nascimento, Michelle Rodriguez, Valerie Vargas Ardila
OneUSF Undergraduate Research Conference
Congenital Zika virus syndrome (CZS) represents a severe and multifaceted outcome of Zika virus (ZIKV) infection during pregnancy, with far-reaching implications for both maternal and neonatal health. ZIVK, transmitted through the Aedes aegypti mosquito vector, has been linked to a range of birth defects, most notably microcephaly. CZS also increases the risk of other complications such as stillbirth, miscarriage, neonatal death, and a spectrum of congenital malformations. Between 2015 and 2016, over 2,000 confirmed cases of microcephaly linked to ZIVK were reported in Brazil, underscoring the epidemic as a public health crisis, particularly in Latin America, where environmental and socio-economic …
The Role Of Estrogen In Lung Health, Aishwarya Aggarwal, Pooja Shree Mohann, Darshana Srivatsava, Jiya Patel
The Role Of Estrogen In Lung Health, Aishwarya Aggarwal, Pooja Shree Mohann, Darshana Srivatsava, Jiya Patel
OneUSF Undergraduate Research Conference
Estrogen, a key sex hormone, significantly influences lung health by modulating inflammation, immune responses, and disease progression. It impacts over 50% of women worldwide, yet the precise mechanisms underlying these effects remain misunderstood. This study evaluates how estrogen influences inflammation and disease progression in lung health, focusing on hormonal imbalances. A systematic review of PubMed and Scopus peer-reviewed literature (2000–2024) was performed. Thirty studies were selected considering their relevance for the role of estrogen in asthma, inflammation, lung cancer, and fibrosis. Studies that were included were experimental models to study estrogen receptors and hormonal effects on disease severity. Experiments also …
Exploring Marine Microbial Products: Targeting Medical Bacteria In Little Bayou Bay, Shivam Anil Patel
Exploring Marine Microbial Products: Targeting Medical Bacteria In Little Bayou Bay, Shivam Anil Patel
OneUSF Undergraduate Research Conference
This study focuses on the identification and curation of microbial natural products, with a specific interest in their potential to target medical-related bacteria. The environment of the Little Bayou Bay was sandy with dirt near alley water that goes out to the Little Bayou Bay. The depth of sample was collected can have different pH level, and bacteria that live in the area. Understanding these reasons why microbial natural target medical-related bacteria can open numerous treatment options. The goal of the research lab is to isolate a bacterium from a sample from Little Bayou Bay. During the lab conduct multiple …
Evaluating The Effect Of Competition On Adult Physical Activity Using Heart Rate Monitoring, Julia De Paula Silva
Evaluating The Effect Of Competition On Adult Physical Activity Using Heart Rate Monitoring, Julia De Paula Silva
OneUSF Undergraduate Research Conference
As of 2023 it has been reported that the United States is facing a physical inactivity crisis, with approximately 24.2% of adults meeting the recommended engagement levels of physical activity (PA). A lack of PA engagement is associated with an increased risk of obesity, type 2 diabetes, cardiovascular disease, and types of cancer (e.g., colon, breast). Therefore, the purpose of the proposed study is to develop a cost-effective behavioral intervention to promote PA among adults. This study will recruit dyads of existing friends between ages 18–65 who engage in low levels of PA (i.e., at least 45 min per week). …
The Impact Of Genistein On Pai-1 Levels And Airway Inflammation In Asthma, Saahil Nayar, Peter Meriga, Mayuresh Behera, Joy Yang
The Impact Of Genistein On Pai-1 Levels And Airway Inflammation In Asthma, Saahil Nayar, Peter Meriga, Mayuresh Behera, Joy Yang
OneUSF Undergraduate Research Conference
Asthma is the fifth leading chronic disorder in the world, affecting hundreds of millions of people yearly. Asthma is a chronic inflammatory disease of the lung airways caused by airway narrowing and remodeling. Plasminogen Activator Inhibitor-1 (PAI-1) has been linked with increased risk of asthma. PAI-1’s production is stimulated by immune cells through the Extracellular signal-Regulated Kinase (ERK) pathway. It inhibits the activity of plasminogen inhibitors, leading to buildup of the extracellular matrix (ECM). ECM buildup leads to airway narrowing, which causes difficulty breathing. Genistein, found in soy, is an isoflavone that has antioxidant and anti-inflammatory properties. This literature review …
Evaluating Extreme Weather And Climate Adaptation Concerns For Corn And Soybean Farmers, Dharsh Saravana
Evaluating Extreme Weather And Climate Adaptation Concerns For Corn And Soybean Farmers, Dharsh Saravana
OneUSF Undergraduate Research Conference
Corn and soybeans are the most economically valuable crops in Minnesota and represent significant land usage in the state with farmers reporting 14.5 million acres of corn and 7 million acres of soybeans planted in 2024. Continued warming and fluctuations between extreme weather events driven by climate change are expected to increase pest pressure, flood damage, and risk of heat stress for crops and farmworkers. Six climate-conscious commercial corn and soybean farmers located predominantly in southern Minnesota were interviewed to understand their perceived extreme weather and climate impacts, farm management responses to these conditions, and risk management concerns for their …
The Role Of Body Shape And Size On Burst Swimming Performance In Marine Reef Fishes, Erica A. Molnar
The Role Of Body Shape And Size On Burst Swimming Performance In Marine Reef Fishes, Erica A. Molnar
OneUSF Undergraduate Research Conference
One of the most important behaviors many animals possess is the ability to flee or escape from predators. In fishes, burst swimming is one of the most common strategies during a predation event. With such strong evolutionary pressure, it is noteworthy that reef fishes from the same habitat exhibit such a wide range in body and fin morphology. For the first time, studies focused on fast-start acceleration have been documented in the field, which offers a more realistic and comprehensive look at natural prey escape response to stimuli. With this level of understanding and observation of more realistic escape responses, …
Harnessing Molecular Docking For Drug Discovery In The Galectin-3 Protein, Attallah Mariam Dean Innis
Harnessing Molecular Docking For Drug Discovery In The Galectin-3 Protein, Attallah Mariam Dean Innis
OneUSF Undergraduate Research Conference
Molecular docking is a fundamental technique in drug discovery, used to predict how a ligand interacts with a target protein or enzyme. This research focuses on the Galectin-3 (G-3) protein, a key factor in excessive scar tissue formation, which is prevalent in pulmonary fibrosis patients. One of the greatest challenges in drug discovery is accurately calculating the binding energy between a potential drug candidate and its target. By constructing drug-protein complexes, binding affinities can be determined using Amber. The selection of the best drug binding affinity corrects the malfunction of the G-3 protein.
Comparison Between Aunp And Tio2np Nanocarriers For The Treatment Of Chronic Obstructive Pulmonary Disease, Andrew Thomas, Vedant Patel, Rohit Borra, Joy Yang
Comparison Between Aunp And Tio2np Nanocarriers For The Treatment Of Chronic Obstructive Pulmonary Disease, Andrew Thomas, Vedant Patel, Rohit Borra, Joy Yang
OneUSF Undergraduate Research Conference
Chronic Obstructive Pulmonary Disease (COPD) is one of the most fatal diseases in the world, leading to lung tissue damage and persistent inflammation. Patients with COPD are typically treated with a bronchodilator and steroids to alleviate bronchoconstriction and inflammation; however, the steroids have limited effects. Inhaled nanomedicine utilizes small agents that facilitate pulmonary-targeted delivery, which improves the absorption and potency of the medication. Over a century ago, Paul Ehrlich proposed the 'magic bullet' theory—targeting diseases precisely while minimizing side effects. Recently, nanomedicine has emerged to support Ehrlich’s theory by fostering nanoparticle drug delivery systems, such as gold (AuNPs) and titanium …
Future Critical Habitat For The Roseate Spoonbill In Florida: A Probabilistic Habitat Suitability Model Based On County Population Growth And Existing Spoonbill Sightings, Ria R. Reynolds
OneUSF Undergraduate Research Conference
Historically, studies surrounding future conservation practices for the roseate spoonbill (Platalea ajaja) have been scarce, instead focusing on ecosystem/community based spatial analyses. The roseate spoonbill has long acted as both a flagship species for conservation and ecotourism and an indicator species of wetland health. However, the lack of focus on this species in research only aids in the disjointed classification of their vulnerability levels – the IUCN Red List labeling them as a species of least concern while the Gulf Coast Vulnerability Assessment describes them as highly vulnerable with the lowest capacity to adapt. An individualized assessment of the roseate …
The United States’ Secret Warfare Against Democracy, Ashtyn J. Smith
The United States’ Secret Warfare Against Democracy, Ashtyn J. Smith
OneUSF Undergraduate Research Conference
This study examines the methods used by the U.S government to orchestrate the overthrow of the democratically elected Guatemalan president Jacobo Árbenz in 1954, by focusing on declassified CIA and State Department documents. Through operation PBSUCCESS, the U.S employed a combination of psychological warfare, economic pressure, diplomatic isolation, and paramilitary operations to destabilize the Árbenz administration. CIA documents reveal the role of propaganda campaigns, assassination proposals, and the arming of opposition forces to create internal chaos. By using primary sources such as CIA memos, and the Foreign Relations of the United States (FRUS) archives, this research will outline the step-by-step …
Srgap2c And The Human Mind: A Genetic Key To Cognitive Evolution, Alexis J. Zayas
Srgap2c And The Human Mind: A Genetic Key To Cognitive Evolution, Alexis J. Zayas
OneUSF Undergraduate Research Conference
The SLIT-ROBO Rho GTPase Activating Protein 2C (SRGAP2C) gene is a human-specific ortholog of murine SRGAP2 and paralog of SRGAP2A, playing a pivotal role in cortical development and neural plasticity. Unlike SRGAP2A, SRGAP2C arose through segmental duplications unique to the Homo lineage approximately 3.4, 2.1, and 1 million years ago. These duplication events coincide with the divergence of early Homo species from Australopithecus and the emergence of increased cognitive abilities and tool use. SRGAP2C functions as a dominant-negative regulator of SRGAP2A by inhibiting its activity. This results in delayed synaptic maturation and increased density of dendritic spines, key factors thought …
Real-Time Decisions, Real-Time Results: The Power Of Point-Of-Care Ultrasound (Pocus), Muhamed M. Jaber, Natalie A. Brin, Andrea Marcano-Rodriguez, Ryan Singh, Grace Faberlle
Real-Time Decisions, Real-Time Results: The Power Of Point-Of-Care Ultrasound (Pocus), Muhamed M. Jaber, Natalie A. Brin, Andrea Marcano-Rodriguez, Ryan Singh, Grace Faberlle
OneUSF Undergraduate Research Conference
Point-of-care ultrasound (POCUS) serves as an invaluable tool in the assessment of anatomical variation, the guidance of invasive interventions and the diagnosis of critical conditions which may lead to changes in plan of care. Using POCUS, anesthesiologists may benefit from this fast diagnostic tool. This technology improves speed, success rate and gets patients to surgery faster. The purpose of this pilot program evaluation was to identify the anesthesiologist’s system and processes for clinical decision-making during the perioperative phases of care. A MANOVA was conducted to identify differences across groups. The independent variable was the type of POCUS scan performed [GU, …
Cardiopulmonary Interactions In Heart Failure And Chronic Lung Disease, Krish Makhija, Rithvik Bhathivi, Riya Narwani, Stuti Dibbur
Cardiopulmonary Interactions In Heart Failure And Chronic Lung Disease, Krish Makhija, Rithvik Bhathivi, Riya Narwani, Stuti Dibbur
OneUSF Undergraduate Research Conference
Globally, cardiovascular diseases, which are directly related to cardiopulmonary interactions, affect over half a billion people and cause 20.5 million deaths in 2021. Cardiopulmonary interactions refer to the complex interactions between the heart and lungs, particularly in diseases where dysfunction in one organ significantly impacts the other. This research aims to discover treatments and prevention methods for Cardiopulmonary Interactions in Heart Failure and Chronic Lung Disease. The aim is to help find early detections of these diseases and educate the public on how to prevent these diseases. A systematic review analyzed 22 peer-reviewed studies out of 45 from 2010 to …
Stem Cell And Regenerative Therapies For Primary Ciliary Dyskinesia: Restoring Ciliary Function With Ipscderived Airway Cells, Riya Hirani, Sriharshini Vasireddy, Dedeepya Kutha, Stuti Dibbur
Stem Cell And Regenerative Therapies For Primary Ciliary Dyskinesia: Restoring Ciliary Function With Ipscderived Airway Cells, Riya Hirani, Sriharshini Vasireddy, Dedeepya Kutha, Stuti Dibbur
OneUSF Undergraduate Research Conference
Primary Ciliary Dyskinesia (PCD) is a genetic disorder that impairs ciliary function, leading to respiratory and fertility issues. While genetic mutations and stem cell-derived airway cells have been explored, effective regenerative therapies are still lacking. This study examines the potential of iPSCs in restoring ciliary function and advancing PCD treatments. Furthermore, it aims to evaluate the effectiveness of iPSC-derived airway cells in replicating functional cilia for potential regenerative therapies in PCD. Additionally, it seeks to identify genetic targets that may enhance treatment strategies. This study reviews existing literature to examine the role of stem cell-derived airway cells on restoring ciliary …
Gpcr-Mediated Mechanisms In Obesity: The Role Of Ghrelin And Glp-1 Receptors, Ryan Singh, Tuana Cenberoglu, Jonathan Budlong, Jaclyn Alejandro, Andrea Weitoschova, Libin Ye
Gpcr-Mediated Mechanisms In Obesity: The Role Of Ghrelin And Glp-1 Receptors, Ryan Singh, Tuana Cenberoglu, Jonathan Budlong, Jaclyn Alejandro, Andrea Weitoschova, Libin Ye
OneUSF Undergraduate Research Conference
G protein-coupled receptors (GPCRs) regulate metabolism and transmit appetite cues throughout the brain and digestive system. Binding to GPCRs, ghrelin, and GLP-1 are ligands that influence hunger, energy balance, and insulin secretion. Understanding the relationship between GPCRs and ligands such as ghrelin and GLP-1 offers critical insights into treating metabolic disorders such as obesity, a growing issue in America. Our methodology involved a literature review using USF, NIH, and JSTOR databases. Search terms like “GPCR obesity,” “GLP-1 obesity,” and related keywords identified articles from 2000 onward, yielding 59 studies on GLP-1 and ghrelin in obesity. GLP-1 receptor agonists (GLP-1RAs), initially …
Perioperative Infection Control And Antibiotic Prophylaxis For Ventriculoperitoneal Shunt Insertion, Andres J. Coll, Luis Diaz, Ana Zurita, Maxx Struhs, Aishwarya Aggarwal
Perioperative Infection Control And Antibiotic Prophylaxis For Ventriculoperitoneal Shunt Insertion, Andres J. Coll, Luis Diaz, Ana Zurita, Maxx Struhs, Aishwarya Aggarwal
OneUSF Undergraduate Research Conference
Infection associated with ventriculoperitoneal (VP) shunt insertion is a problem faced by many hydrocephalus patients, often caused by gram-positive bacteria. Research has identified infection rates in neonatal and pediatric patients, and frequent procedural errors that raise the risk of infection; but the effectiveness of specific antibiotic treatments and protocols requires further exploration. This study evaluates antibiotic prophylaxis and perioperative infection control to determine the most effective preventative measures in reducing the infection rate in VP shunt insertion procedures by analyzing existing literature and comparing infection outcomes in patients. A literature review was conducted to examine the success of perioperative procedures …
Point Of Care Ultrasound (Pocus): No Hocus Among Anesthesiologists, Andrea Camila Marcano-Rodriguez, Natalie Andrade Brin, Muhamed Muntaser Jaber, Grace Victoria Faberlle, Ryan Singh, Donna Gambino
Point Of Care Ultrasound (Pocus): No Hocus Among Anesthesiologists, Andrea Camila Marcano-Rodriguez, Natalie Andrade Brin, Muhamed Muntaser Jaber, Grace Victoria Faberlle, Ryan Singh, Donna Gambino
OneUSF Undergraduate Research Conference
An anesthesiologist’s ability to recognize the intrinsic utility of Point of Care Ultrasound (POCUS) as a diagnostic tool may improve patient safety, decrease anesthesia time, and maximize patient outcomes. Evidence suggests that POCUS is a safe, inexpensive, non-invasive, portable, and easily accessible perioperative tool. The purpose of study was to identify the anesthesiologists’ systems and processes for clinical decision-making utilizing POCUS for patients during the perioperative phases of care. A MANOVA was conducted to identify differences across groups. The independent variable was the type of POCUS scan performed [GU, Cardio, Gastric, Pulmonary]. The dependent variables were the anesthesiologists’ processes for …
The Effects Of Sleep Deprivation On Cognitive Function Of University Students, Ikshita Achanta, Anthony Hamati, Vanessa Singh, Joanne Nguyen, Rebecca Pothen, Reneta Pothen, George Malki, Bhavisha Hirani
The Effects Of Sleep Deprivation On Cognitive Function Of University Students, Ikshita Achanta, Anthony Hamati, Vanessa Singh, Joanne Nguyen, Rebecca Pothen, Reneta Pothen, George Malki, Bhavisha Hirani
OneUSF Undergraduate Research Conference
Sleep is vital for college students, directly influencing their cognitive, emotional, and physical health, which are crucial for academic success and overall well-being. Sleep deprivation affects memory consolidation, learning, focus, problem-solving, and decision-making, all of which are essential for retaining knowledge, applying it in assignments, and excelling academically. By strengthening neural connections, adequate sleep enhances critical thinking and productivity, while its absence leads to reduced concentration and impaired cognitive performance. Sleep deprivation tends to affect multiple areas of the brain in regard to neural activity, alertness, and cognitive function. Our investigation examines the impact of sleep deprivation on undergraduate cognitive …
Unveiling Suicide Risk In Bipolar Disorder Communities: Static Graph Analysis And Comparative Modeling On Reddit Networks, Phong Hai Tran, Jessica Elrefaei
Unveiling Suicide Risk In Bipolar Disorder Communities: Static Graph Analysis And Comparative Modeling On Reddit Networks, Phong Hai Tran, Jessica Elrefaei
OneUSF Undergraduate Research Conference
Suicide risk detection in online mental health communities poses significant challenges, particularly within bipolar disorder support groups where user interactions are diverse and complex. This study presents a foundational investigation using graph neural networks (GNNs) to model Reddit-based communities through both homogeneous and heterogeneous static graphs. In our homogeneous graph, where all users and interactions are treated uniformly, we extract key centrality measures—degree, closeness, betweenness, eigenvector, and PageRank—to identify influential users and understand the network structure. To capture the richer semantics of the heterogeneous graph, we derive meta-path-based centrality measures that leverage predefined meta-paths to uncover deeper relational patterns among …
Evolutionary Optimization Of Biologically-Inspired Mechanistic Input-Output Neural Circuit Models In The Auditory Pathway, Abdul-Malik Zekri
Evolutionary Optimization Of Biologically-Inspired Mechanistic Input-Output Neural Circuit Models In The Auditory Pathway, Abdul-Malik Zekri
OneUSF Undergraduate Research Conference
Understanding how to compute specific functions from neural architecture is a fundamental challenge in neuroscience, with profound implications for artificial intelligence, neuromorphic computing, and neurological health. This study employs evolutionary meta-heuristic algorithms to optimize a mechanistic input-output spiking neural network (SNN) model of the cochlear nucleus, a key circuit in the auditory pathway. The research integrates biologically inspired initialization, iterative optimization, and data-driven validation to explore how connectivity and topology influence input-output relationships in neural circuits. Synthetic input-output spike train pairs for spiral ganglion and bushy cells are generated using a computational model of the cochlear nucleus. SNNs are initialized …
B-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibiting Peptidomimetics, Jianfeng Cai, Peng Sang, Yan Shi, Haitao Ji, Min Zhang
B-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibiting Peptidomimetics, Jianfeng Cai, Peng Sang, Yan Shi, Haitao Ji, Min Zhang
USF Patents
Disclosed herein is a series of helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). As disclosed herein, sulfono-γ-AApeptides can structurally and functionally mimic the α-helical domain of BCL9, and selectively disrupt β-catenin/BCL9 PPIs with even higher potency. More intriguingly, these sulfono-γ-AApeptides can enter cancer cells, bind with β-catenin and disrupt β-catenin/BCL PPI, and exhibit excellent cellular activity, which is much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies demonstrated the remarkable stability of the helical sulfono-γ-AApeptides, with no degradation in the presence of pronase for 24 h, augmenting their …
Human Origin Probiotic Lactobacillus Rhamnosus Hl-200 To Reduce Leaky Gut By Metabolizing Ethanolamine, Hariom Yadav, Shalini Jain, Sidharth Mishra
Human Origin Probiotic Lactobacillus Rhamnosus Hl-200 To Reduce Leaky Gut By Metabolizing Ethanolamine, Hariom Yadav, Shalini Jain, Sidharth Mishra
USF Patents
The present disclosure provides for a method of treating increased gut permeability, including administering a therapeutically effective amount of a human-derived probiotic to a patient in need thereof. Further provided herein is a method of increasing a patient's metabolism of ethanolamine, including administering a therapeutically effective amount of human derived probiotics to the patient in need thereof. Also provided herein is a pharmaceutical composition, including a first strain of Lactobacillus and a second probiotic strain. The present disclosure also provides for a pharmaceutical composition, including Lactobacillus and an antidiabetic drug. Additionally, provided herein is a pharmaceutical composition, including Lactobacillus and …
Control Of Robotic Arms Through Hybrid Inverse Kinematics And Intuitive Reference Frame, Lei Wu, Redwan Alqasemi, Rajiv Dubey
Control Of Robotic Arms Through Hybrid Inverse Kinematics And Intuitive Reference Frame, Lei Wu, Redwan Alqasemi, Rajiv Dubey
USF Patents
Disclosed is an intuitive robotic device control reference frame with hybrid inverse kinematics having a natural and easier human-robot interface. A system for controlling a robot can include a robotic device that performs tasks, an input device that receives user input indicating desired movement of the robotic device to perform the tasks, and a controller that controls the robotic device based on the user input. The controller can receive signals identifying the user input, determine a ground reference frame and an end-effector reference frame for controlling movement of the robotic device, generate, based on the ground reference frame and the …