Digital Commons Network^™

Targeting Cancer-Anorexia Cachexia Syndrome And Septic Inflammatory-Based Atrophy With R/S 1,3 Butanediol Acetoacetate Diester, Andrew P. Koutnik

USF Tampa Graduate Theses and Dissertations

Cancer anorexia cachexia syndrome (CACS) is a distinct atrophy disease negatively influencing multiple aspects of clinical care and patient quality of life. Although it directly causes 20% of all cancer-related deaths, there are currently no model systems that encompass the entire multifaceted syndrome, nor are there any effective therapeutic treatments. Here, we show that the VM-M3 mouse model of systemic metastasis demonstrates a novel, immunocompetent, logistically feasible, repeatable phenotype with progressive tumor growth, spontaneous metastatic spread, and the full multifaceted CACS with expected sex dimorphisms across tissue wasting. We also demonstrate that the ubiquitin proteasomal degradation pathway was significantly upregulated …

Accelerated Viral Dynamics In Bat Cell Lines, With Implications For Zoonotic Emergence, Cara E. Brook, Mike Boots, Kartik Chandran, Andrew P. Dobson, Christian Drosten, Andrea L. Graham, Bryan T. Grenfell, Marcel A. Müller, Melinda Ng, Lin-Fa Wang, Anieke Van Leeuwen

KIP Articles

Bats host virulent zoonotic viruses without experiencing disease. A mechanistic understanding of the impact of bats’ virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dynamics is needed to elucidate zoonotic emergence. We carried out virus infectivity assays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoretical model of our in vitro system, which we fit to empirical data. Best fit models recapitulated expected immune phenotypes for representative cell lines, supporting robust antiviral defenses in bat cells that correlated with higher estimates for within-host viral propagation rates. In general, heightened immune responses limit …

Crow's Nest, February 3, 2020, Crow's Nest Staff

Crow's Nest

The February 3, 2020, issue of the Crow's Nest.

Cutr Connections [February 2020], Cutr

CUTR Newsletters

No abstract provided.

People With Parkinson’S And Care Partners Of Pwps’ Uncertainty Management Through Information Strategies, Amy Haywood

USF Tampa Graduate Theses and Dissertations

This thesis explores how people with Parkinson’s (PwP) and care partners of PwP manage the uncertainty surrounding Parkinson’s disease (PD). PD causes both motor and cognitive decline in patients, which may affect each individual differently (Williamson, Simpson, & Murray, 2008). There is no-known cure or cause for PD, meaning it is shrouded in uncertainty from the first symptom to the ongoing management process. This disease also affects care partners because of its variability in symptoms and progression. For this reason, this research, which is part of a larger study, interviewed both care partners of PwP (n= 10) and those diagnosed …

An Exploration Of Teachers’ Use Of Culturally Responsive Pedagogy, Ethic Of Care, And Reflectivity, Johan Von Ancken

USF Tampa Graduate Theses and Dissertations

A variety of educational reform literature discusses the “ethic of care” and “building relationships,” along with culturally relevant/responsive pedagogy (Gorski, 2013; Guajardo, M., Guajardo F., & Casaperalta, 2008; Ladson-Billings, 1992, 1995). In addition, “Appreciative Organizing in Education (AOE)” (Barrett & Fry, 2008; Burello, Beitz, & Mann, 2015; Cooperrider, Whitney, & Stavros, 2008) with its emphasis on strengths-based analysis of organizational change shaped my perception that a “Culture of Care” in our schools and with our teachers, administrators, and most importantly students, is necessary.

The notion of “culturally appropriate” (Au & Jordan, 1981, p. 139) pedagogy began over 35 years ago …

The Weekly Challenger, January 30, 2020, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The January 30, 2020, issue of The Weekly Challenger.

Male And Female Students’ Persistence In Stem Fields In Community Colleges: A Secondary Analysis Of Nces Bps:12/14 Data, Ying Hu

USF Tampa Graduate Theses and Dissertations

Today, economic growth, technology advancement, and daily life are all driven by science, technology, engineering and math (STEM). American colleges and universities need to produce more STEM graduates in order to meet rapid job growth. The purpose of this study was to determine the significant factors that influence the persistence of STEM students in community colleges. The research described the characteristics of STEM students who persisted and of those who did not in STEM, as well as the different characteristics between male and female students. It also investigated student and institutional factors that influenced STEM students’ persistence. Furthermore, the study …

Rainfall, Precipitation, And Drought Patterns Associated With Wintertime Transmission Of Eastern Equine Encephalitis Virus (Eeev) In Florida, Bestami Cevher

USF Tampa Graduate Theses and Dissertations

Eastern Equine encephalitis virus (EEEV) is a highly pathogenic alphavirus that causes disease in humans and horses. EEEV cases are common in the eastern North America, especially in horses in the State of Florida. EEEV cases are most common in Florida during May to August but also occur year-round, unlike most other locations. According to the Florida Department of Health, 65 EEEV horse cases were documented in the winter months between 2005 and 2018. This study investigates the meteorological activities that affect the wintertime transmission of the EEEV virus to horses. In this, we examined meteorological data up to a …

Adolescent Asthma And School Disparities: An Ecological Perspective Of Students And Stakeholders, Tali Schneider

USF Tampa Graduate Theses and Dissertations

Asthma is a chronic condition that mainly affects adolescents. Recent reports from the Centers for Disease Control and Prevention (CDC) indicate a gradual increase in rates of lifetime asthma among adolescents from 17.1% in 2005 to 22.8% in 2015. Currently, one in ten adolescents nation-wide experience active asthma; similar trends are seen in the state of Florida (Florida Asthma Program, 2013; Centers for Disease Control and Prevention, Prevention, 2015). As a chronic, lifelong condition, asthma can be life-threatening if not properly controlled. When exacerbated, attacks of asthma constrict airways, leading to restrained breathing, wheezing, coughing and chest pain (Parulekar, Alobaidy, …

The Effect Of Acute Interpersonal Racial Discrimination On Smoking Motivation And Behavior Among Black Smokers, Patricia F. Calixte-Civil

USF Tampa Graduate Theses and Dissertations

In comparison to White smokers, Black smokers are more likely to report both discrimination and less success in smoking cessation. No previous study has tested the causal relationship between actual experienced racial discrimination and smoking variables associated with cessation. The goal of this study was to test the casual influence of interpersonal racial discrimination on smoking motivation (i.e., the urge to smoke cigarettes, cessation self-efficacy, and smoking behavior) using a controlled experimental design. We used a virtual ball-playing game to create a laboratory model of racial discrimination. A 2x2 between-subjects factorial design (inclusion/exclusion vs. ingroup/outgroup) was used to randomly assign …

Affect And Craving: Examining The Differential Influences Of Positive And Negative Affect On Inclinations To Approach And Avoid Alcohol Use, Jacob A. Levine

USF Tampa Graduate Theses and Dissertations

Most research examining the role of affect in the etiology of alcohol craving has been limited to associations between negative affect and the desire to consume alcohol. This narrow focus has not only ignored the potential influence of positive affect on the desire to use alcohol, but has led to a failure to consider both desires to avoid using alcohol and motivational conflicts often thought to be present in alcohol use disorders (AUDs). Additionally, research investigating the influence of affect on attentional bias in favor of alcohol cues in individuals who have an AUD has been limited. Using 60 individuals …

Energy-Aware Digital Signatures, Attila Altay Yavuz, Muslum Ozgur Ozmen, Rouzbeh Behnia

USF Patents

A digital signature protocol achieves the least energy consumption, the fastest signature generation, and the smallest signature among its ECC-based counterparts. The method of authenticating is also immune to side channel attacks aiming elliptical curve operations/exponentiations as well as to weak pseudo random number generators at the signer's side. A security system for authenticating the updating of computer records includes a network of member computers in data communication with each other and calculating an assigned portion of a commitment code used for the authenticating the secure data at the verifier device by completing, among the server computers, a plurality of …

Beta-Lactamase Inhibitors, Formulations, And Uses Thereof, Yu Chen, Orville Antonio Pemberton, Adam Renslo, Priyadarshini Jaishankar

USF Patents

Provided herein are heterocyclic compounds and pharmaceutical formulations that can be used to treat bacterial infections. Also provided herein are methods of making and using the heterocyclic compounds and pharmaceutical formulations.

Crow's Nest, January 27, 2020, Crow's Nest Staff

Crow's Nest

The January 27, 2020, issue of the Crow's Nest.

Algorithms Enabling Communications In The Presence Of Adjacent Channel Interference, Berker Peköz

USF Tampa Graduate Theses and Dissertations

Newer cellular communication generations are planned to allow asynchronous transmission of multiple numerologies (waveforms with different parameters) in adjacent bands, creating unavoidable adjacent channel interference (ACI). Contemporary windowed-orthogonal frequency division multiplexing (W-OFDM) algorithms have limited ACI rejection capability under high delay spread and small fast Fourier transformation (FFT) sizes. CP is designed to be longer than the maximum excess delay (MED) of the channel to accommodate such algorithms in current standards. Most prior work on windowing assume additional extensions reserved for windowing, which does

not comply with standards. The robustness of these algorithms can only be improved against these conditions …

Counseling Skills And Behaviors Of Genetic Counselors: A Qualitative Study, Abigail Zale

USF Tampa Graduate Theses and Dissertations

Research is needed to ensure the frameworks created to ensure best clinical practice for the genetic counseling (GC) profession align with current GC clinical practice. Nineteen practicing genetic counselors in prenatal, pediatric, or cancer specialties were interviewed to elicit their session goals and the counseling skills utilized within sessions and to determine how closely responses align with the Framework for Outcomes in Clinical Communication Services (FOCUS) and Reciprocal Engagement Model (REM). As part of a qualitative content analysis guided by FOCUS, quotes extracted and coded into key themes using RQDA software demonstrated consistency with REM goals and categories within the …

Functional Significance Of Endothelial Sigma-1 Receptors In Vascular Reactivity And Barrier Function, Zeinab Y. Motawe

USF Tampa Graduate Theses and Dissertations

The sigma-1 receptor (σ1) is a single 25 kD polypeptide that acts as a chaperone protein residing primarily in the endoplasmic reticulum Its interaction with mitochondria at the mitochondria-associated ER membrane domain is well-documented. Following activation, σ1 binds to the inositol trisphosphate receptor (Hayashi & Su), and modulates intracellular calcium homeostasis. Also, the activated σ1 modulates plasma membrane receptors and ion channel functions, and may regulate cellular excitability. Further, σ1 affects trafficking of lipids and proteins essential for neurotransmission, cell growth and motility. Activation of σ1 provides neuroprotection and cardio-protection in various models. Examples of neuroprotection include but not limited …

Gabbing While Gaming: Commandeering Commercial, Off-The-Shelf (Cots) Video Games To Structure Student-Centered Social Studies Discussion, Joshua M. Patterson

USF Tampa Graduate Theses and Dissertations

Amidst the current cultural backdrop of debilitating digital addiction and malicious misinformation campaigns, secondary social studies instructors require every possible tool to engage students stuck in the haze of simulated reality. While nationwide mastery of the subject area is wedged between failure (National Assessment of Educational Progress, 2020) and apathy, three-dimensional, entertainment-driven simulations are progressing at an exponential rate of adolescent adoption and historical accuracy. In this phenomenological case study, I capitalize on pupils’ preference for virtual integration by outlining a pedagogical approach that harnesses the trinity of content knowledge, discursive prowess, and video game aptitude. Video game titles were …

Effects Of Learning A Second Language On English Academic And Low-Frequency Vocabulary Acquisition And Metalinguistic Knowledge, Hayriye Karliova

USF Tampa Graduate Theses and Dissertations

This study compared the possible effects of learning a language from the Italic branch of the Indo-European language family as a second language (L2), namely Latin and Spanish, on English academic and low-frequency vocabulary acquisition and metalinguistic knowledge of native English speaker (NES) undergraduates in their first language (L1), English.

The study sought to attain two objectives: first, it aimed to discover the effects of learning Latin and Spanish as L2s with respect to the vocabulary acquisition of NES undergraduates; second, it aimed to detect the effects these L2s in terms of metalinguistic awareness. In both cases, the focus was …

Novel Insights Into Immune Systems Of Bats, Arinjay Banerjee, Michelle L. Baker, Kirsten Kulcsar, Vikram Misra, Raina Plowright, Karen Mossman

KIP Articles

No abstract provided.

The Weekly Challenger, January 23, 2020, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The January 23, 2020, issue of The Weekly Challenger.

Survey Of Histoplasma Capsulatum In Bat Guano And Status Of Histoplasmosis In Slovenia, Central Europe, Janez Mulec, Saša Simčič, Tadeja Kotar, Romina Kofol, Sanja Stopinšek

International Journal of Speleology

There have been increasing reports on the presence of Histoplasma capsulatum in some European countries. The study investigated the presence of Histoplasma in bat guanos, speleologists with records of visiting Histoplasma-endemic regions and patients with histoplasmosis. A commercial ALPHA Histoplasma Antigen enzyme immunoassay was tested as an alternative methodology to detect Histoplasma in environment and compared with polymerase chain reaction (PCR) assays. The presence of Histoplasma antigen in bat guanos was not confirmed by PCR. Among 14 healthy speleologists, two were indicated as having the Histoplasma antigen in urine, but expressed negative PCR-specific results for the Histoplasma antigen. Five …

Compounds For The Treatment Of Neurodegenerative Diseases, Jianfeng Cai, Chuanhai Cao

USF Patents

Disclosed herein are compounds for the treatment of neurodegenerative diseases and compositions comprising the same.

Introducing The Art Of Statistics: How To Learn From Data, David Spiegelhalter

Numeracy

Spiegelhalter, David. 2019. The Art of Statistics: How to Learn from Data (New York, NY: Basic Books) 448 pp. ISBN 978-1541618510.

This short piece introduces readers to The Art of Statistics: How to Learn from Data, a new book by David Spiegelhalter. In this age of data, classic statistical courses can appear of limited relevance due to their focus on probability-based methodology. The book takes a modern approach to introducing the essential concepts of statistical science, avoiding mathematics and structured around real problems that data can help solve, many based on the author's own experience.

The Author’S Reflections On No B.S. (Bad Stats): Black People Need People Who Believe In Black People Enough Not To Believe Every Bad Thing They Hear About Black People, Ivory A. Toldson

Numeracy

Toldson, Ivory. A. 2019. No BS (Bad Stats): Black People Need People Who Believe in Black People Enough Not to Believe Every Bad Thing They Hear About Black People (Boston, MA: Brill-Sense) 194 pp. ISBN 978-9004397026.

This essay provides an introduction to No BS (Bad Stats): Black People Need People Who Believe in Black People Enough Not to Believe Every Bad Thing They Hear About Black People. In the essay, the author discusses how cynical views about the educational potential of Black children motivated him to write a book that challenges negative statistics. The essay also outlines the harmful …

Planting Seeds Of Numeracy: Supporting Quantitative Literacy In Young Children, Jennifer Ward, Victoria J. Damjanovic

Numeracy

This paper aims to present how quantitative literacy was made a focus in a preschool classroom of three- and four-year-old children. With a focus on examining two areas of quantitative literacy, number knowledge and counting (Jordan, Kaplan, and Locuniak 2007) we seek to explore how educators, within an early childhood setting, used a project approach (Katz, Chard, and Kogan, 2014) and inquiry-based practices to build and extend upon the emerging competencies of the children. Utilizing narrative inquiry (Clandinin & Connelly, 2000), we draw from planning meeting notes, lesson plans, and lesson artifacts to construct a story that chronicles the journey …

Avoiding Over-Diagnosis: Exploring The Role Of Gender In Changes Over Time In Statistics Anxiety And Attitudes, Kelly Rhea Macarthur

Numeracy

The importance of quantitative literacy for creating and maintaining a democratic and just society is unequivocal, but undergraduate students often do not acquire these important skills. One barrier to teaching quantitative literacy skills is students’ anxiety. The empirical evidence of the extent of the problem, however, does not seem to match anecdotal accounts of instructors who may be “diagnosing” statistics anxiety as universal among students and across different sources of anxiety. The purpose of this study is to identify the specific aspects of statistics anxiety that present barriers to student success by employing the Statistics Anxiety Rating Scale (STARS) to …

Effects Of Quantitative Literacy On Healthcare Decision-Making: An Aural Context, Robert G. Root, Sonia Bhala

Numeracy

We propose a relationship between sensory modality, numerical formatting, and performance on a survey simulating healthcare decision-making. We examine the current literature on aural health literacy, and specifically aural literacy coupled with health numeracy. We then create a survey instrument called the Bhala test for this purpose and demonstrate that it is moderately internally consistent and provides results that correlate with the NUMi assessment, a widely accepted measure of health numeracy. The quantitative information provided in the Bhala test has two treatments, percentage and natural frequency formats, in an effort to determine which format is easier for subjects to use …

The Past, Present And Future Of Q-Step – A Programme Creating A Step-Change In Quantitative Social Science Skills, Steve Grundy

Numeracy

This article provides an outline of the conception and implementation to date of Q-Step, a national programme to make high-level quantitative skills an essential element of teaching and learning in social sciences across the UK. Q-Step has supported the development and delivery of specialist undergraduate programmes (including new courses, work placements, and pathways to postgraduate study) in order to increase the number of quantitatively trained social scientists in the UK. There are 17 UK universities currently participating in the programme which has been funded by the Nuffield Foundation, the Economic and Social Research Council (ESRC), and the former Higher Education …