Digital Commons Network^™

Newborn Screening For X-Linked Adrenoleukodystrophy: Experiences, Perspectives, And Future Directions For Genetic Counseling, Sophia Salvatore

Theses and Dissertations

There is a notable lack of research regarding genetic counseling practices for infants with screen-positive results for X-linked adrenoleukodystrophy (X-ALD) via newborn screening (NBS). The exploratory study aimed to understand the experiences of genetic counselors providing follow-up care for these infants, assess the complexities associated with NBS for X-ALD, identify potential gaps in genetic counseling practices, and describe the subsequent impact on patient care. A mixed-methods approach was utilized, incorporating an initial survey and optional semi-structured interviews with practicing genetic counselors who had seen a minimum of five cases of infants with screen-positive results for X-ALD in the last two …

Exploring Modernist Traits In The Guitar Works Of Manuel María Ponce, Michael William Bunny

Theses and Dissertations

Music of the early twentieth century developed drastically from that of previous eras. With Debussy’s emphasis on tone color and timbre, Stravinsky’s rhythmic complexities, and Bartók’s incorporation of folk music, the twentieth century had a far different sound to that which preceded it. Each of these composers demonstrated different practices of this new genre called modernism. However, likely due to Andrés Segovia’s dislike of modernist music, there were not many popular composers that followed this trend in the guitar world. Those composing for the guitar shied away from attributes of modernism, ensuring that their works would be played. Manuel María …

Child-Caregiver Relational Closeness And Child Mental Health In Nonparental Care Settings, Amanda Stafford Mcrell

Theses and Dissertations

This dissertation examines child-caregiver relational closeness and child mental health within nonparental care systems in Low- and Middle-Income countries (LMICs). Five key factors impacting the well-being of orphaned, separated, and vulnerable children in LMICs are explored using the Positive Outcomes for Orphans (POFO) dataset: child maltreatment, social support, child-caregiver relationships, and nonparental care systems. First, I examined the relationship between maltreatment, social support, and mental well-being. Findings showed that maltreatment was associated with lower mental well-being, where social support (emotional support, tangible support, positive social support) was associated with greater mental well-being, even in the concurrent presence of maltreatment. Second, …

Genetics Education Booklets Designed For Individuals With Intellectual Disability: Perspectives From Adults With Intellectual Disability And Genetic Counselors, Audrey Hyun Sook Parrott

Theses and Dissertations

Visual aid tools have been consistently suggested across literature aimed at identifying methods of improving health and genetics services for individuals with intellectual disability (ID). Aids written in plain language are suggested most often. The study intends to gain perspectives from adults with ID (AWID) and genetic counselors (GCs) on Easy Read genetics educational booklets designed for individuals with mild ID. We anticipate that GCs will find the booklets to be useful and accurate, and that AWID will find the booklets to be helpful to their understanding and comprehensible. The AWID were assessed via a self-reported survey, cognitively adapted for …

An Exploratory Study Of Disclosure Of X-Linked Conditions Between Mothers And Daughters, Madge Isabella Stuhlreyer

Theses and Dissertations

Carriers of X-linked conditions, both asymptomatic and symptomatic, face unique challenges regarding their experiences navigating the healthcare system and understanding implications of their carrier status. Studies show that mothers are known to be the main communicators of genetic information within their families, but in families affected with X-linked conditions, communication between mothers and daughters are hindered by factors such as lack of knowledge about the condition and reproductive implications, lack of emotional support, anxiety, and uncertainty about how to initiate these conversations. The purpose of this study was to explore the motivations behind mothers' decisions to initiate conversations with their …

Barriers In Receiving A Diagnosis Of Sanfilippo Syndrome: Perceptions From Healthcare Providers And Caregivers, Cassidy Lena

Theses and Dissertations

Sanfilippo syndrome (MPS III) is a rare, degenerative condition characterized by symptoms impacting neurological functioning, behavior, and quality of life. Diagnosis is often not made until three to six years of age, but comprehensive and effective symptom management have been reported to optimize patient longevity. The aim of this study was to identify barriers to diagnosis and the corresponding impact on patients. This study surveyed healthcare providers and caregivers of individuals with Sanfilippo syndrome. Both quantitative and qualitative methods were employed to assess provider knowledge and comfortability in managing Sanfilippo syndrome. Additionally, it explored caregiver perspectives on healthcare system navigation, …

The Association Between Parent’S Mobile Device Use And Physical Activity, Sydney Hill

Theses and Dissertations

Background. The rapid increase in mobile technology has allowed smartphones to be used almost anywhere, but a potential disadvantage of these mobile devices is the displacement of physical activity. Parents of young children are already struggling to reach higher intensities of physical activity and mobile devices might make this worse. However, most existing research on similar topics look at adults without children or uses subjective measures only. Therefore, this study aims to (1) quantify objective mobile device use from a sample of parents with preschool age children; (2) describe the duration and intensity of parents’ physical activity and inactive behavior; …

The Role Of B Cells In Promoting Lipid Absorption By Promoting Lacteal Development, Kenny Johnson

Theses and Dissertations

The absorption of dietary lipids in the gut is necessary to maintain the metabolic tone of tissues. Inflammation in the gut can cause defects in lipid absorption, which can result in tissue wasting, otherwise known as cachexia. Cachexia is commonly observed in patients with inflammatory bowel disease and cancer patients. The underlying cause of cachexia is unknown, and there are currently no effective therapeutic options available to treat it. Lymphatic drainage in the small intestine (SI) is specialized to promote the transport of dietary lipids into circulation. Lacteals are blunt-ended lymphatic vessels localized to the central axes of villi in …

Unveiling Hidden Voices: A Guide For Expanding Collegiate Coursework To Include Female Opera Composers And Their Works, Veronica Kimberly Page

Theses and Dissertations

Opera, often viewed as a prestigious and elite art form, has been predominantly shaped by male composers throughout its history. The contributions of women composers in opera have been largely overlooked, however, despite their significant impact on the genre. This dissertation explores the role of female composers in opera, from pioneers like Francesca Caccini to contemporary figures such as Missy Mazzoli, arguing for the creation of a curriculum focused on their works. Such a course would fill a critical gap in higher education, offering a more inclusive understanding of opera’s history and evolution. Through an examination of women’s compositions, historical …

A Novel Geometric Modeling Kernel For Automated Fiber Placement, Rowen Burney

Theses and Dissertations

Automated Fiber Placement (AFP) is a key manufacturing technique for producing high-performance composite structures, yet existing geometric modeling frameworks lack the specialized functionality required for efficient toolpath planning and laminate optimization. This work presents Knots, a Geometric Modeling Kernel (GMK) developed specifically to address these limitations by providing a unified geometric foundation tailored for AFP. Unlike general-purpose Computer Aided Design (CAD) libraries, Knots is optimized for AFP, offering specialized geometric operations that streamline the transition from design to manufacturing. It directly manages the loading and computation of geometric data, ensuring structured laminate generation while supporting automation and scripting for improved …

Bridging Tradition And Interpretation: Overdotting In J.S. Bach's Keyboard Music And Recorded Practice, Jiamo Zhang

Theses and Dissertations

Abstract This dissertation presents a research and quantitative study about overdotting performance practice in Baroque music. Overdotting is a performance practice in the 17th and 18th century. It refers to playing dotted rhythms with exaggerated lengthening of the dotted note and shortening of the following note, beyond what is indicated in the notation. In this study, the dual evidence method is applied for cross-verifying recorded performances in the past century with published literature on performance practice of the interpretation of overdotted Baroque performance tradition in J.S. Bach’s solo keyboard work recorded since the early 20th century. The analysis focuses on …

The Role Of Platform Design In Excessive Short Form Video Use And The Resulting Impacts On Cognitive Processes, Katherine Levey

Senior Theses

Short form video (SFV) platforms such as TikTok and Instagram Reels have rapidly reshaped global media consumption. This thesis investigates how the defining technological elements of SFV platforms contribute to prolonged viewing behavior by inducing flow, a psychological state characterized by deep immersion and diminished self-awareness. Through a review of nineteen scholarly articles, this study examines how features like infinite scroll, auto-play, and algorithmic personalization create a low-effort, high-reward user experience that sustains attention and facilitates continuous engagement. Once immersed, users often fall into a cycle of passive, prolonged scrolling, consuming more content and spending more time than intended. Findings …

The Contribution Of Individual Movements To The Learning Of A Movement Sequence, Hannah K. Ammons

Senior Theses

This thesis explores how the overall learning of a motor sequence through repeated practice is impacted by the individual movement’s components. Changes seen in the response time, peak velocity, and the hand path distance were examined whilst considering the Fitts’s ID and inertial demands of the individual movements. During data collection, twenty-four right-handed participants completed a series of repeated and random reaching movements that varied in direction and distance in a 3D virtual environment. When considering only the repeated sequences, the results indicated significant improvement in both the hand path distance and response time across all target combos, specifically Target …

Opioid Treatment Matters: An Analysis Of District Attorney Non-Prosecution, Samuel A. Maloney

Senior Theses

Drug use and drug overdose have become an overriding concern both for civic order and due to the raw death toll from the opioid epidemic. One reform push in the late 2010s/early 2020s, county-level District Attorneys signalling that they would not prose- cute drug use and related crimes, aimed to reduce overdose by reducing criminalization and stigma as a barrier to opioid treatment. At its peak, the policy covered between twenty and thirty million Americans. Using hand-collected data on District Attorney policies and Augmented Synthetic Control for causal identification, I estimate null ef- fects of non-prosecution policies on an urban …

The Effect Of Grape Seed Extract Against The Formation Of S.Aureus Biofilms In A Clinical Setting, Srestha Samaddar

Senior Theses

The rise of antibiotic-resistant bacterial infections, particularly those caused by Staphylococcus aureus, poses a serious threat to public health and clinical care. A major contributor to the persistence of these infections is the formation of bacterial biofilms, structured communities that protect S. aureus from antibiotics and immune responses, especially on surgical sites and medical devices. As conventional treatments become less effective, interest in alternative, natural antimicrobial agents has increased, due to public dissatisfaction with conventional medicine and a growing trust in complementary and alternative medicine. Grape seed extract (GSE), a polyphenol-rich byproduct of winemaking, has emerged as a promising candidate …

The Roles Of Literature And Film In Shaping Culture: An Examination Of All Quiet On The Western Front And The German Lesson, Charles Hansen

Senior Theses

This paper examines the cultural impacts of All Quiet on the Western Front (Im Westen nichts Neues) and The German Lesson (Deutschstunde). More specifically, it examines the impacts of the works through the shaping of German identity and public memory following World War I and World War II, as well as any long-term impacts that have lasted into the present day. These two works of literature, as well as their respective film adaptations, can serve as vehicles for national reflection, education, and confrontation of the past. This paper will examine the key themes of All Quiet …

Genetic Counseling As An Emerging Global Profession: Exploring Commonalities And Collaborations Among 15 Countries, Evelyn J. Leary

Senior Theses

Since 1969, the genetic counseling profession has expanded to almost 50 countries and is now considered a global profession. This paper’s goal was to explore the evolution of genetic counseling over time and among varied countries and to identify common themes in the establishment of the profession internationally. Each country known to have practicing genetic counselors was sorted into one of five categories: the first four were by the first training program’s establishment year, and the fifth included countries with genetic counselors but no domestic training program. Three countries from each category were selected to be highlighted based on factors …

Life In Greece After The Financial Crisis: A Quality-Of-Life Perspective, Kylee Nicole Hynes

Senior Theses

After World War II, Greece faced economic struggles which led to its EU accession in 1981. In the following years, the use of credit increased and so did consumer debt. The global financial crisis of 2008 exposed Greece’s weak economy and caused the debt crisis. This led to multiple EU-IMF (International Monetary Fund) bailouts. This study examines how the crisis affected Greek citizens’ quality of life. This study specifically focuses on mental, physical, and socioeconomic health. Overall, mental and socioeconomic health worsened while physical health remained unchanged. All mental health indicators deteriorated with higher rates of depression, anxiety, and post-traumatic …

Combating Forced Labor In Global Supply Chains Through Modern Technology: A Case Study Of Uyghurs In Xinjiang, Samuel Donohue

Senior Theses

This thesis examines how modern traceability technologies can help combat forced labor in global supply chains, focusing on the case of Uyghur workers in Xinjiang, China. The research addresses the pressing challenge of verifying ethical labor practices in complex, multi-tiered supply networks, using the case study alongside an extensive literature review. It evaluates advanced technological solutions, including blockchain ledgers, isotope analysis, radio-frequency identification (RFID) tagging, and microbiome tracing as tools to improve supply chain transparency. Through qualitative case analysis and analysis of current research, the thesis assesses each technology’s capability to trace product origins and authenticate labor conditions. The findings …

Shifting Healthcare In Rural South Carolina: A Study Of Media Coverage Of The Effects Of Hospital Closures, Morgan Harper

Senior Theses

Rural hospital closures have become an increasingly urgent issue in healthcare across the United States. These closures have impacted access to healthcare, the job market, and general community health. Most hospitals have been forced to close due to low patient volumes, financial struggles, and corporate ownership. Immediate implications of closures include the displacement of healthcare workers, community concern about lacking a central healthcare facility, and increased travel times to access care.

This thesis examines South Carolina’s healthcare landscape in areas with hospital closures since 2012 and explores the effects of and responses to these closures as discussed in newspapers and …

The Impact Of Discretion On Human Service Workers Supporting The Health Of Unaccompanied Minors In Foster Care, Diana M. Clark

Senior Theses

Unaccompanied children (UCs) are a vulnerable population that enters government custody and accesses healthcare via the Office of Refugee Resettlement (ORR)'s system of care. While prior research has focused on generating policy recommendations to improve healthcare services available to UCs both in ORR custody and following release from custody, this thesis will instead expand upon the experiences of staff members working at ORR-contracted agencies. These workers make decisions that have short- and long-term implications on the health and wellbeing of UCs. Drawing from 65 in-depth interviews with human service workers in ORR-contracted voluntary agencies, this thesis uses street-level bureaucracy framework …

Impacts On College-Aged Asian American Mental Health, Zahra Soherwardy

Senior Theses

This study explores the relationship between different forms of racial harassment and mental health issues in Asian American college students. Asian American mental health is a growing concern in the field of public health. Asian Americans have the lowest treatment rates and some of the highest stigma levels of any demographic. They are also impacted by the model minority myth and discrimination, further alienating them from getting help. The topics of subtle racism, blatant racism, and current racial discrimination were compared to depressive symptoms, anxiety, self-esteem, and four domains of aggression using survey data. Subtle racism was found to be …

Deference Or Preference: Analyzing The Treatment Of Chevron U.S.A., Inc. V. Nrdc As A Precedent At The Supreme Court, Allison Dehart

Senior Theses

Chevron U.S.A., Inc. v. Natural Resources Defense Council, Inc. is one of the most cited Supreme Court cases in history, with over 18,000 citations in federal courts alone (Merrill, 2012). It has reached doctrinal status and was widely considered a vital precedent, one that guided the fields of environmental and administrative law. However, in June of 2024, the Supreme Court released their opinion in Loper Bright Enterprises v. Raimondo, which overturned Chevron. With the ubiquity of Chevron in US Courts, this decision caused widespread confusion and worry over what would replace the precedent. In an era where environmental …

Raising Red Flags: Exploring Phenotypic Change In Tiger Moths (Apantesis) Of Coastal Sc Over 50 Years' Time, Allison K. Fletcher

Senior Theses

Organismal phenotypes play a critical role in ecological interactions and individual fitness, and they may undergo rapid shifts through evolutionary adaptation or phenotypic plasticity in response to climate change and environmental disturbances. As morphological traits such as body size, melanization, and aposematic coloration are especially significant for thermoregulation and predator deterrence, it is important to understand the ways in which these traits may be changing on a regional level. Here, I examined the change in phenotype in populations of three tiger moth (Apantesis) species from a single site in coastal South Carolina over a fifty-year period, testing for differences in …

Individual Differences In The Effects Of A Muscarinic Antagonist On Cued Fear Recall And Extinction, Caitlyn J. White

Senior Theses

Post-Traumatic Stress Disorder (PTSD) is characterized by an inability to extinguish fear after experiencing a traumatic event. The cholinergic system shows increased activity during fear learning and extinction, suggesting a role for cholinergic transmission in PTSD. Our lab has previously found that rats can be divided into extinction resistant (ER) and extinction competent (EC) phenotypes, with ER representing a PTSD-like phenotype. While women are more likely to develop PTSD, there is limited literature on the cholinergic system and recall of cued fear or extinction in female rats which are used as a model system due to their similar brain anatomy. …

Differential Gene Coexpression In 16p11.2 Autism Spectrum Disorder, Joseph Patacsil

Senior Theses

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has been associated with several genetic factors. One of these factors is a mutation of the 16p11.2 region on chromosome 16, in which both deletions and duplications have been strongly associated with ASD. KCTD13 is a gene in the 16p11.2 gene locus that has recently been shown to influence brain development and is also associated with ASD. This study analyzes the differential gene expression and gene pathways of these different phenotypes. KCTD13 deletion had a significant up-regulation effect on genes and shares similar pathways to the 16p11.2 duplication mutation. Mutations in …

Illustrations Of Benevolent And Hostile Heterosexism In Lgbtq+ People’S Lives, Jes L. Matsick, Lindsay Palmer, Flora Oswald, Mary Kruk, Kenneth Ye

Faculty Publications

In this study, we aimed to define heterosexism—a form of sexual stigma that accounts for interpersonal attitudes and institutionalized ideology—in a multi-dimensional way, centering on LGBTQ+ people’s experiences. We draw from an ambivalent theory of prejudice and focus on heterosexism, or an ideology that stigmatizes nonheterosexual behaviors, identities, relationships, and communities. We aimed to learn how LGBTQ+ people would narrate their experiences of heterosexism within a benevolent and hostile framing. In a qualitative online study, LGBTQ+ participants (N = 77; 49% White) reviewed definitions of and recalled encounters with benevolent and hostile heterosexism, providing examples of how heterosexism manifests …

Racial And Ethnic Inequalities In Actual Vs Nearest Delivery Hospitals, Nansi S. Boghossian, Lucy T. Greenberg, Jeffrey S. Buzas, Joshua Radack, Molly Passarella, Jeannette Rogowski, George R. Saade, Ciaran S. Phibbs, Scott A. Lorch

Faculty Publications

IMPORTANCE Minoritized racial and ethnic groups, such as American Indian and Black individuals, often receive lower quality health care compared with White individuals. There is limited understanding of how these disparities extend to obstetric care, particularly when comparing the quality of care at the actual delivery hospital vs the nearest obstetric hospital based on the birthing individual’s residence. OBJECTIVE To examine inequality in care based on the actual delivery hospital and the closest delivery hospital to the birthing individual’s residential zip code centroid. DESIGN, SETTING, AND PARTICIPANTS This population-based retrospective cohort study used data from 5 states (2008 to 2020 …

Family Risk Classes Predict Longitudinal Parent And Child Outcomes: Understanding The Implications Of Poverty-Related Adversity, Daniel K. Cooper, Benjamin L. Bayly, Brianna Tennie, Francesca Lupini, Martha E. Wadsworth

Faculty Publications

Experiencing poverty and associated risk factors can be detrimental to families’ mental health and well-being. However, it is unclear whether experiencing specific types or patterns of adversity leads to distinct outcomes. Guided by the Family Stress Model, the objective of this study was to (a) identify unique family risk classes based on exposure to various combinations of poverty-related adversity and (b) examine whether the family risk classes differed in their levels of parental coping strategies, couple relationship quality, parenting practices, and child behavior problems. The sample included 301 mother–father–child triads (602 adults and 301 children) with a combined income ≤ …

“Burned At The Stake”: Unpacking Disinformation In The Story Of A Coach Allegedly “Terminated” For Expressing Anti-Transgender Women Athlete Beliefs, Ellen J. Staurowsky

Journal of Issues in Intercollegiate Athletics

On August 29, 2023, a video testimony entitled ‘Burned at the Stake’: One NCAA Coach’s Battle to Protect Women’s Sport was released. The film was part of a “female athlete storytelling series” developed and funded by the Independent Women’s Forum (IWF) designed to support the IWF’s stated agenda to “fight to save women’s sports and counter the radical agenda that seeks to erase women” by allowing transgender girls and women on teams that match their identities. The central figure in the video is Kim Russell, then head women’s lacrosse coach at NCAA Division III Oberlin College, who claimed her right …