Digital Commons Network^™

Yinyang-Align: Benchmarking Contradictory Objectives And Proposing Multi-Objective Optimization Based Dpo For Text-To-Image Alignment, Amitava Das, Yaswanth Narsupalli, Gurpreet Singh, Vinija Jain, Vasu Sharma, Suranjana Trivedi, Aman Chadha, Amit Sheth

Publications

As Text-to-Image (T2I) models become more advanced, they face a fundamental challenge—balancing conflicting alignment goals such as faithfulness vs. artistic freedom, realism vs. stylization, and verifiability vs. creativity. Existing alignment methods often optimize for one objective at the cost of another, leading to inconsistencies in AI-generated images.
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/="/">In our latest work, YinYang-Align, we introduce a benchmarking framework to systematically evaluate these trade-offs and propose Contradictory Alignment Optimization (CAO)—a multi-objective extension of Direct Preference Optimization (DPO) that enables models to navigate competing alignment goals more effectively.

February 5, 2025 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

An Investigation Of Travel Distance And Timeliness Of Breast Cancer Treatment Among A Diverse Cohort In The United States, Swann Arp Adams Ph.D., Ms, Face, Oluwole Adeyemi Babatunde, Whitney E. Zahnd, Peiyin Hung Ph.D., Karen E. Wickersham Phd, Rn, Nathaniel Bell Ph.D., Jan M. Eberth Ph.D.

Publications

Travel to and from distant cancer treatment facilities can place a significant burden on cancer patients, particularly rural and minority survivors. Thus, the purpose of our investigation was to examine the association between patient travel distance and delays in types of treatment for breast cancer (surgery, radiation, chemotherapy, and hormonal therapy) and treatment delays. Using a novel linkage between the state cancer registry and administrative data from Medicaid and a private insurance plan, 2155 BC patients were successfully linked to create the cohort. ArcGIS was used to geocode all case residences and treatment facility addresses and calculate network distance between …

Post-Term Births As A Risk Factor For Small For Gestational Age Births And Infant Mortality In Brazil, Mexico, And Palestinian Refugees: An Analysis Of Electronic Birth Records, Zeina Jamaluddine, Lorena Suarez Idueta, Enny S. Paixao, Julia M. Pescarini, Hala Ghattas Ph.D., Miho Sato, Akihiro Seita, Luis A. Martinez-Juarez, Mauricio L. Barreto, Eric O. Ohuma, Louise T. Day, Oona M.R. Campbell, Hannah Blencowe

Faculty Publications

Background:

Post-term pregnancy, defined as reaching or exceeding 42 + 0 weeks of gestation, is known to be associated with unfavourable birth outcomes. High-income countries have responded to this risk by widely adopting labour induction protocols in late-term, but many low- and middle-income countries have not. However, understanding underlying mechanisms linking post-term births to adverse newborn and infant outcomes remains limited.

Objective:

To investigate the (a) prevalence of post-term, (b) the risk factors associated with post-term (c) the association between post-term births and the risk of small-for-gestational-age (SGA) neonates and of infant mortality in middle-income settings.

Methods:

We used existing …

On The Books In South Carolina: Mining For Jim Crow Laws, Kate F. Boyd, Vandana Srivastava, Lance Dupre, Christopher Frear, Nitin Gupta, Bobby Donaldson

Faculty and Staff Publications

On the Books in South Carolina: Mining for Jim Crow Laws is a collections-as-data and machine learning project by the University of South Carolina Libraries (USC), sub awarded by the University of North Carolina at Chapel Hill (UNC), and made possible by The Andrew W. Mellon Foundation, for the period of May 2022 - December 2024. Following UNC’s steps from their first year of the grant, the USC project created a text corpus of South Carolina state legislature acts passed in the period from Reconstruction through the Civil Rights Movement (1868-1968). The USC team then utilized machine learning techniques to …

Reply To: Amplifying Women's Voices In Menopause Research: The Importance Of Inclusive Perspectives [Letter], Camille Cronin, Sara Donevant Phd, Rn, Ccrn, Kerri-Ann Hughes, Marja Kaunonen, Jette Marcussen, Rhonda Wilson

Publications

No abstract provided.

Amplifying Women's Voices In Menopause Research: The Importance Of Inclusive Perspectives, Camille Cronin, Sara Donevant Phd, Rn, Ccrn, Kerri Ann Hughes, Marja Kaunonen, Jette Marcussen, Rhonda Wilson

Publications

Menopause, a significant life transition for half the global population, intersects biological, cultural and social dimensions. Despite its universal occurrence, menopause research has historically been dominated by biomedical perspectives, often neglecting women's voices and diverse experiences. This article highlights the importance of including women's perspectives in menopause research to ensure relevance, accuracy and equity. It explores cultural variations in menopause experiences, the impact of socioeconomic status and the often-overlooked emotional and psychological dimensions. This article advocates for participatory approaches, emphasising that women's involvement enhances research design, implementation and policy development. Evidence-based interventions that are tailored to the individual can better …

The Built Environment And Place Attachment: Insights From Japanese Cities, Juiling Li, Mohammed Javad Koohsari, Andrew T. Kaczynski, Ryo Tanimoto, Reo Watanabe, Tomoki Nakaya, Yufeng Luo, Jing Zhao, Akitomo Yasunaga, Koichiro Oka, Tomoya Hanibuchi

Faculty Publications

Objective

Methods

Results

Association Of Racial Residential Segregation And Other Social Determinants Of Health With Hiv Late Presentation, Fanghui Shi, Jiajia Zhang Ph.D., Shujie Chen, Xueying Yang Ph.D., Zhenlong Li, Sharon Weissman, Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Understanding social determinants of HIV late presentation with advanced disease (LPWA) beyond individual-level factors could help decrease LPWA and improve population-level HIV outcomes. This study aimed to examine county-level social determinants of health (SDOH) with HIV late presentation. We aggregated datasets for analysis by linking statewide HIV diagnosis data from the South Carolina (SC) Enhanced HIV/AIDS Reporting System and multiple social contextual datasets (e.g., the American Community Survey). All adult (18 years and older) people with HIV diagnosed from 2014 to 2019 in SC were included. Linear mixed models with forward selection were employed to explore the association of county-level …

Childhood Sexual Trauma, Substance Use, And Antiretroviral Therapy Adherence Among Older Adults Living With Hiv: A Mediational Analysis, Monique J. Brown, Josie Zhang, Prince Nii Ossah Addo, Amandeep Kaur, Daniel Amoatika, Elizabeth L. Crouch Ph.D., Steven A. Cohen

Faculty Publications

Childhood sexual abuse (CSA) is linked to substance use and lower antiretroviral therapy (ART) adherence. However, studies examining the mediational role of substance use between CSA and ART adherence are lacking. Therefore, the aim of this study was to determine the potential mediational role of substance use between CSA and ART adherence among older adults living with HIV (OALH) (n = 91). Mediation analyses assessed the direct and indirect relationships between CSA, substance use, and ART adherence. Statistically significant differences existed in substance use by gender (male vs. female: 12.3 vs. 9.97) and ART adherence by race (Black vs. …

Pilot Study: Initial Investigation Suggests Differences In Emt-Associated Gene Expression In Breast Tumor Regions, Kylie L. King, Hamed Abdollahi, Zoe Dinkel, Alannah Akins, Homayoun Valafar, Heather Dunn

Faculty Publications

Triple negative breast cancer (TNBC) is the most aggressive subtype and disproportionately affects African American women. The development of breast cancer is highly associated with interactions between tumor cells and the extracellular matrix (ECM), and recent research suggests that cellular components of the ECM vary between racial groups. This pilot study aimed to evaluate gene expression in TNBC samples from patients who identified as African American and Caucasian using traditional statistical methods and emerging Machine Learning (ML) approaches. ML enables the analysis of complex datasets and the extraction of useful information from small datasets. We selected four regions of interest …

Predicting Individual Long-Term Prognosis Of Spatial Neglect Based On Acute Stroke Patient Data, Lisa Röhrig, Daniel Wiesen, Dongyun Li, Chris Rorden, Hans-Otto Karnath

Faculty Publications

One of the most pressing questions after a stroke is whether an individual patient will recover in the long term. Previous studies demonstrated that spatial neglect—a common cognitive deficit after right hemispheric stroke—is a strong predictor for poor performance on a wide range of everyday tasks and for resistance to rehabilitation. The possibility of predicting long-term prognosis of spatial neglect is therefore of great relevance. The aim of the present study was to test the prognostic value of different imaging and non-imaging features from right hemispheric stroke patients: individual demographics (age, sex), initial neglect severity and acute lesion information (size, …

Population Variability Across Geographical Ranges: Perspectives And Challenges, Cleber Ten Caten, Tad Dallas

Faculty Publications

Populations fluctuate over time and across geographical space, and understanding how different factors contribute to population variability is a central goal in population ecology. There is a particular interest in identifying trends of population variability within geographical ranges as population densities of species can fluctuate substantially across geographical space. A common assumption is that populations vary more near species geographical range edges because of unsuitable environments and higher vulnerability to environmental variability in these areas. However, empirical data rarely support this expectation, suggesting that population variability is not related to its position within species geographical ranges. We propose that performance …

Perceived Healthiness Of Sugary Drinks And Related Social Norms Among Adults In Five Countries: Evidence From The International Food Policy Study, Virginie Drolet-Labelle

Faculty Publications

Background

A better understanding of correlates of sugary drink consumption is essential to inform public health interventions. This study examined differences in perceived healthiness of sugary drinks and related social norms between countries, over time, and sociodemographic groups and associations with sugary drink intake.

Methods

This study used annual cross-sectional data from the International Food Policy Study from 2018 to 2021 in Australia, Canada, the United Kingdom, the United States, and Mexico. Analyses examined perceived healthiness of eight beverage types and two types of perceived social norms (descriptive, injunctive) that discourage sugary drink consumption. The 24-item Beverage Frequency Questionnaire was …

An Investigation Of Travel Distance And Timeliness Of Breast Cancer Treatment Among A Diverse Cohort In The United States, Swann Arp Adams, Oluwole Adeyemi Babatunde, Whitney Zahnd, Peiyin Hung, Karen E. Wickersham, Nathaniel Bell Ph.D., Jan M. Eberth Ph.D.

Publications

Travel to and from distant cancer treatment facilities can place a significant burden on cancer patients, particularly rural and minority survivors. Thus, the purpose of our investigation was to examine the association between patient travel distance and delays in types of treatment for breast cancer (surgery, radiation, chemotherapy, and hormonal therapy) and treatment delays. Using a novel linkage between the state cancer registry and administrative data from Medicaid and a private insurance plan, 2155 BC patients were successfully linked to create the cohort. ArcGIS was used to geocode all case residences and treatment facility addresses and calculate network distance between …

Amplifying Women’S Voices In Menopause Research: The Importance Of Inclusive Perspectives, Camille Cronin, Sarah B. Donevant Phd, Rn, Ccrn, Kerri-Ann Hughes, Marja Kaunonen, Jette Marcussen, Rhonda Wilson

Faculty Publications

Menopause, a significant life transition for half the global population, intersects biological, cultural and social dimensions. Despite its universal occurrence, menopause research has historically been dominated by biomedical perspectives, often neglecting women's voices and diverse experiences. This article highlights the importance of including women's perspectives in menopause research to ensure relevance, accuracy and equity. It explores cultural variations in menopause experiences, the impact of socioeconomic status and the often-overlooked emotional and psychological dimensions. This article advocates for participatory approaches, emphasising that women's involvement enhances research design, implementation and policy development. Evidence-based interventions that are tailored to the individual can better …

Niaid Workshop Report: Systematic Approaches For Eskape Bacteria Antigen Discovery, Inka Sastalla, Keehwan Kwon, Clayton Huntley, Kimberly A. Taylor Dnp, Rn, Nea-Bc, Cnor, Clssbb, Liliana Brown, Tamika Samuel, Lanling Zou

Publications

On 14-15 November 2023, the National Institute of Allergy and Infectious Diseases (NIAID) organized a workshop entitled "Systematic Approaches for ESKAPE Bacteria Antigen Discovery". The goal of the workshop was to engage scientists from diverse relevant backgrounds to explore novel technologies that can be harnessed to identify and address current roadblocks impeding advances in antigen and vaccine discoveries for the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). The workshop consisted of four sessions that addressed ESKAPE infections, antigen discovery and vaccine efforts, and new technologies including systems immunology and vaccinology approaches. Each …

January 15, 2025 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Associations Between Social Determinants Of Health And Mental Health Disorders Among U.S. Population: A Cross-Sectional Study, S. Tanarsuwongkul

Faculty Publications

Aims

The impact of social determinants of health (SDOH) on mental health is increasingly realized. A comprehensive study examining the associations of SDOH with mental health disorders has yet to be accomplished. This study evaluated the associations between five domains of SDOH and the SDOH summary score and mental health disorders in the United States.

Methods

We analyzed data from a diverse group of participants enrolled in the All of Us research programme, a research programme to gather data from one million people living in the United States, in a cross-sectional design. The primary exposure was SDOH based on Healthy …

Gotta Take My Avatar Shopping: Impacts Of Interactive Virtual Shopping In Esport, Yongjin Hwang, Keshav Gupta

Faculty Publications

Purpose

Esports game developers are incorporating interactive virtual shopping (IVS) experiences into their products to facilitate consumer–brand interactions. Despite the potential influence of IVS, existing research lacks an understanding of its impact on consumers’ overall affect– particularly game enjoyment, a critical factor in sustaining engagement with esports products – and on attitudinal change toward brands in the real world.

Design/methodology/approach

An experiment was designed to examine the impact of shopping in the virtually interactive esports marketplace on game enjoyment. Mediating effects of positive change in brand attitude, perceived realism and character attachment and the moderating effect of self-avatar gender congruity …

How Agency From Precollege Experiences Empowers Black Student-Athletes To Succeed And Find Belonging At Pwis: A Phenomenological Study, Deborah V. Hogan

Journal of Issues in Intercollegiate Athletics

In the ever-changing college football landscape, Division I (DI) student-athletes seek to maximize their athletic and financial potential while navigating the academic and social challenges of college life. For Black student-athletes (BSAs) at predominantly White institutions (PWIs), the campus racial climate shapes their college experience and sense of belonging. The current phenomenological study explores how DI Black football student-athletes (BFSAs) use agency from precollege experiences to navigate racial climates and find belonging at PWIs. Using Critical Race Theory (CRT) and sense of belonging frameworks, semi-structured interviews were conducted with 13 former BFSAs from DI PWIs. The study revealed three main …

Co-Development Of A Gamified Physical Education Movement Competence Intervention With School Stakeholders, Jenna Rice, Lawrence Foweather, Jonathan Foulkes, Ceriann Magill, An V. De Meester, David F. Stodden Ph.D., Matthieu Lenoir, Katie Fitton Davies

Faculty Publications

Movement competence (MC) and emotional intelligence (EI) are positively associated and important for child development. Intervention research is needed to determine causal relationships between these outcomes. Gamification is a pedagogical model that may enhance MC and EI, but implementing interventions in schools is complex and requires multi-stakeholder involvement to ensure feasibility, acceptability and sustainability. However, methodological evidence to inform co-development work within physical education (PE) is lacking and further research is required. This study describes the process of co-developing a gamified PE intervention with school stakeholders to increase MC and EI among primary-aged children. A total of 91 children and …

Organizational Readiness For Implementation: A Qualitative Assessment To Explain Survey Responses, Maria Mcclam, Lauren Workman, Timothy J. Walker, Emanuelle M. Dias, Derek W. Craig, Joe R. Padila, Andrea E. Lamont, Abraham Wandersman, Maria E. Fernandez

Faculty Publications

Background

One factor considered essential to successful implementation is organizational readiness. The purpose of this study was to explore ways to improve the measurement of organizational readiness, and in particular to refine a preliminary measure based on the Readiness = Motivation x innovation Specific Capacity x General Capacity (R = MC2) heuristic. We assessed the experiences of staff in Federally Qualified Health Centers (FQHC) implementing evidence-based interventions (EBIs) designed to increase colorectal cancer screening (CRCS) who previously completed the survey and aimed to understand their perspectives on why our data were positively skewed.

Methods

We conducted a series of qualitative …

A Survey On Food Ingredient Substitutions, Hyunwook Kim, Revathy Venkataramanan, Amit P. Sheth

Publications

Diet plays a crucial role in managing chronic conditions and overall well-being. As people become more selective about their food choices, finding recipes that meet dietary needs is important. Ingredient substitution is key to adapting recipes for dietary restrictions, allergies, and availability constraints. However, identifying suitable substitutions is challenging as it requires analyzing the flavor, functionality, and health suitability of ingredients. With the advancement of AI, researchers have explored computational approaches to address ingredient substitution. This survey paper provides a comprehensive overview of the research in this area, focusing on five key aspects: (i) datasets and data sources used to …

Exploring The Potential Of Malvidin And Echiodinin As Probable Antileishmanial Agents Through In Silico Analysis And In Vitro Efficacy, Luis Daniel Goyzueta-Mamani, Daniela Pagliara Lage, Haruna Luz Barazorda-Ccahuana, Margot Paco-Chipana, Mayron Antonio Candia-Puma, Gonzalo Davila-Del-Carpio, Alexsandro Sobreira Galdino, Ricardo Andrez Machado-De-Avila, Rodolfo Cordeiro Giunchetti, Edward L. D'Antonio, Eduardo Antonio Ferraz Coelho, Miguel Angel Chávez-Fumagalli

Natural Sciences Faculty Publications

Leishmaniasis, a neglected tropical disease caused by Leishmania species, presents serious public health challenges due to limited treatment options, toxicity, high costs, and drug resistance. In this study, the in vitro potential of malvidin and echioidinin is examined as antileishmanial agents against L. amazonensis, L. braziliensis, and L. infantum, comparing their effects to amphotericin B (AmpB), a standard drug. Malvidin demonstrated greater potency than echioidinin across all parasite stages and species. Against L. amazonensis, malvidin’s IC50 values were 197.71 ± 17.20 μM (stationary amastigotes) and 258.07 ± 17 μM (axenic amastigotes), compared to echioidinin’s 272.99 ± 29.90 μM and 335.96 …

Metabolism Of Co And H2 By Pioneer Bacteria In Volcanic Soils And The Phyllosphere, Nicola Fantom, Robin A. Dawson Phd, Rn, Cpnp-Pc, Edina Prondvai, Philippe Constant, Gary M. King, Hendrik Schäfer, Marcela Hernández

Publications

Trace gas degradation is a widespread metabolic adaptation in microbial communities, driving chemosynthesis and providing auxiliary energy that enhances persistence during nutrient starvation. In particular, carbon monoxide and hydrogen degradation can be of crucial importance for pioneering microbial communities colonising new, oligotrophic environmental niches, such as fresh volcanic deposits or the aerial interface of the phyllosphere. After volcanic eruptions, trace gas metabolism helps pioneer colonisers to initiate soil formation in ash deposits and on recently solidified lava, a vital ecosystem service. Similarly, in the phyllosphere, bacteria colonising newly emerging leaves and shoots, and/or persisting on the oligotrophic surface of plants, …

Exploring The Potential Of Large Language Models For Assisting With Mental Health Diagnostic Assessments: The Depression And Anxiety Case, Kaushik Roy, Harshul Surana, Darssan Eswaramoorthi, Yuxin Zi, Vedant Palit, Ritvik Garimella, Amit Sheth

Publications

Large language models (LLMs) are increasingly attracting the attention of healthcare professionals for their potential to assist in diagnostic assessments, which could alleviate the strain on the healthcare system caused by a high patient load and a shortage of providers. For LLMs to be effective in supporting diagnostic assessments, it is essential that they closely replicate the standard diagnostic procedures used by clinicians. In this paper, we specifically examine the diagnostic assessment processes described in the Patient Health Questionnaire-9 (PHQ-9) for major depressive disorder (MDD) and the Generalized Anxiety Disorder-7 (GAD-7) questionnaire for generalized anxiety disorder (GAD). We investigate various …

The Blue Economy Comes To Green Creek, Ursula Ramsey

South Carolina Journal of International Law and Business

Oceans, touted as the “next great economic frontier,” are projected to contribute three trillion dollars to the global economy. Beyond their economic potential, oceans provide a host of environmental benefits: oceans supply over half of the planet’s oxygen and contain nearly all of the Earth’s water and biosphere. Especially because the high seas represent one of the few remaining global commons, oceans present a governance challenge. Meeting this challenge is the concept of the blue economy, a form of governance that combines environmental stewardship, economic development, and social equity. This article, in discussing Mulvihill v. South Carolina Department of Health …

The Efficacy And Usability Of Motivational Interviewing Just-In-Time Trainings For Youth Mentors, Mackenzie J. Hart, Samuel D. Mcquillin, Aidyn Iachini Ph.D., Msw, Lsw, Daniel K. Cooper, Mark D. Weist

Faculty Publications

Using youth mentors to deliver evidence-based psychosocial services has been proposed to increase the reach of treatments, in part given the affordability and ubiquity of mentors in youth settings. Further, tests of mentor-delivered motivational interviewing (MI) have shown increases in youth mentees' academic performance and wellbeing. Yet, traditional methods of training mentors to use MI can be costly and time-consuming. Previous work has suggested the value of asynchronous, brief, just-in-time training (JITT) to help offset these challenges; however, MI JITT for mentors has not yet been formally evaluated. As such, here, we report on a preliminary study of MI JITT …

Preliminary Evaluation Of A Brief Intervention To Enhance Trauma-Informed Attitudes Among Educators And School Mental Health Counselors, Cheri Shapiro, Kara Lee, Courtnie Collins, Tristan Collier, Carl Sorensen

Publications

Professional development training designed to advance knowledge of the impacts of trauma and trauma-responsive practices for educators and counselors in schools and mental health settings have become common. Given the popularity of these training approaches, it is important to understand the potential impact on trauma-informed attitudes and beliefs. This descriptive, exploratory study examined changes in traumainformed care attitudes as a function of participating in a novel intervention designed to support trauma-informed practices in a sample of elementary school educators, administrators, and school mental health counselors (n=194) from one state in the Southeastern US. Positive changes in trauma-informed attitudes from pre …