Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (28)
- Physical Sciences and Mathematics (28)
- Engineering (26)
- Psychiatry and Psychology (24)
- Life Sciences (18)
-
- Marine Biology (11)
- Biology (6)
- Business (4)
- Tourism and Travel (4)
- Education (3)
- Social and Behavioral Sciences (2)
- Aerospace Engineering (1)
- Anthropology (1)
- Art and Design (1)
- Arts and Humanities (1)
- Chemistry (1)
- Cognitive Science (1)
- Dance (1)
- Disability and Equity in Education (1)
- East Asian Languages and Societies (1)
- Educational Methods (1)
- Educational Psychology (1)
- Educational Sociology (1)
- English Language and Literature (1)
- Environmental Sciences (1)
- Film and Media Studies (1)
- Gender Equity in Education (1)
- Gender and Sexuality (1)
- Interdisciplinary Arts and Media (1)
- Japanese Studies (1)
- Keyword
-
- Humans (142)
- Animals (92)
- Female (59)
- Climate change (58)
- Male (58)
-
- Biodiversity (50)
- Adult (35)
- Aquaculture (35)
- Conservation (34)
- Ecology (32)
- Middle Aged (31)
- Ecosystem (29)
- Microplastics (24)
- Fish (23)
- Marine (23)
- Models (22)
- Aged (20)
- Behaviour (20)
- Meningioma (20)
- Ocean acidification (20)
- Young Adult (20)
- Microplastic (19)
- Biogeography (18)
- Climate Change (18)
- Education (18)
- Sustainability (18)
- Ecosystem services (17)
- Environment (17)
- Fisheries (17)
- Hypoxia (17)
- Publication Year
- Publication
-
- School of Biological and Marine Sciences (2061)
- School of Geography, Earth and Environmental Sciences (631)
- Peninsula Medical School (535)
- School of Biological and Marine Sciences Theses (432)
- School of Engineering, Computing and Mathematics (388)
-
- School of Psychology (343)
- School of Biomedical Sciences (341)
- The Plymouth Student Scientist (281)
- School of Geography, Earth and Environmental Sciences Theses (215)
- Other Faculty of Science and Engineering Theses (201)
- School of Health Professions (158)
- School of Art, Design and Architecture (144)
- School of Engineering, Computing and Mathematics Theses (115)
- School of Nursing and Midwifery (110)
- Peninsula Dental School (106)
- Other Faculty of Health Theses (93)
- Other Faculty of Arts, Humanities and Business Theses (92)
- School of Law, Humanities and Social Sciences (62)
- School of Psychology Theses (52)
- More Faculty of Science and Engineering Research (45)
- Plymouth Business School (42)
- More Faculty of Health Research (38)
- Peninsula Medical School Theses (35)
- School of Art, Design and Architecture Theses (35)
- School of Law, Humanities and Social Sciences Theses (34)
- Plymouth Institute of Education (26)
- Faculty of Science and Engineering Datasets (22)
- Plymouth Business School Theses (21)
- School of Biomedical Sciences Theses (19)
- The Plymouth Law and Criminal Justice Review (19)
- Publication Type
- File Type
Articles 5821 - 5850 of 6794
Full-Text Articles in Entire DC Network
Integration Of Action And Language Knowledge: A Roadmap For Developmental Robotics, A Cangelosi, G Metta, G Sagerer, S Nolfi, C Nehaniv, K Fischer, J Tani, T Belpaeme, G Sandini, F Nori, L Fadiga, B Wrede, K Rohlfing, E Tuci, K Dautenhahn, J Saunders, A Zeschel
Integration Of Action And Language Knowledge: A Roadmap For Developmental Robotics, A Cangelosi, G Metta, G Sagerer, S Nolfi, C Nehaniv, K Fischer, J Tani, T Belpaeme, G Sandini, F Nori, L Fadiga, B Wrede, K Rohlfing, E Tuci, K Dautenhahn, J Saunders, A Zeschel
School of Engineering, Computing and Mathematics
This position paper proposes that the study of embodied cognitive agents, such as humanoid robots, can advance our understanding of the cognitive development of complex sensorimotor, linguistic, and social learning skills. This in turn will benefit the design of cognitive robots capable of learning to handle and manipulate objects and tools autonomously, to cooperate and communicate with other robots and humans, and to adapt their abilities to changing internal, environmental, and social conditions. Four key areas of research challenges are discussed, specifically for the issues related to the understanding of: 1) how agents learn and represent compositional actions; 2) how …
Common House Spiders Could Be Vectors Of Community-Acquired Methicillin-Resistant Staphylococcus Aureus, Richard Roberts
Common House Spiders Could Be Vectors Of Community-Acquired Methicillin-Resistant Staphylococcus Aureus, Richard Roberts
The Plymouth Student Scientist
Aim: To identify whether common household spiders such as Tegenaria saeva and Amaurobius ferox are likely vectors and reservoirs for Methicillin-Resistant Staphylococcus aureus. Methods and Results: Spiders were tested for the presence of S.aureus on the fangs, lower and upper abdomen and the legs. S.aureus was isolated from the fangs and isolates were subcultured to test for oxacillin resistance. Of the sample that was tested a mean of 83.4 x 102 cfu/fang for total counts of S.aureus was found. While 23% of the isolates tested for oxacillin-resistance were oxacillin resistant. Conclusion: Common household spiders can easily act as vectors and …
Environmental Factors And Patterns Of Behaviour In Zoo-Housed Sumatran Tigers, Panthera Tigris Sumatrae, Kimberley Jayne
Environmental Factors And Patterns Of Behaviour In Zoo-Housed Sumatran Tigers, Panthera Tigris Sumatrae, Kimberley Jayne
The Plymouth Student Scientist
This study investigated how increased environmental predictability in captivity can impact upon animal behaviour. ‘Busyness’ was piloted as a method of measuring activity in relation to environmental factors and observations were conducted on the behaviour of 2 zoo-housed Sumatran tigers, Panthera tigris sumatrae. Graphical analysis revealed the tigers to show increased Busyness leading up to the time they were taken off-show, possibly indicating anticipation of this event. Both animals displayed stereotyped pacing within specific enclosure sections. The female tiger showed increased pacing leading up to the time she was taken off-show, whereas the male showed the opposite. Suggestions were made …
The Cytotoxic Effect Of Glycerophospholipid: Cholesterol Acyltransferase (Gcat) On Mammalian And Fish Cell Lines In Vitro, Andrew Moriarty
The Cytotoxic Effect Of Glycerophospholipid: Cholesterol Acyltransferase (Gcat) On Mammalian And Fish Cell Lines In Vitro, Andrew Moriarty
The Plymouth Student Scientist
Glycerophospholipid: cholesterol acyltransferase (GCAT) is an enzyme produced by the bacteria Aeromonas salmonicida. A. salmonicida is the causative agents of the fish disease furunculosis and GCAT is an important enzyme when considering the virulence and progression of this disease. This study aims to show how the cytotoxic affects of the GCAT enzyme can vary between mammalian and fish cells. Both cloned and crude native forms of GCAT were exposed to mammalian and fish cell lines and observed for signs of damage over a 24 hour period. The cloned GCAT extraction was exposed to both fish and mammalian erythrocytes, while the …
The Effect Marina Design And Recreational Boating Has On The Spread Of Non Indigenous Species, Amy Brock-Morgan
The Effect Marina Design And Recreational Boating Has On The Spread Of Non Indigenous Species, Amy Brock-Morgan
The Plymouth Student Scientist
The spread of Non Indigenous Species (NIS) is a global problem and has major implications for the pattern of local biodiversity and ultimately the functioning of ecosystems. Invasive NIS are recognised as a major threat to biodiversity in article 8 on the Convention of Biological Diversity (CBD). Once NIS are introduced controlling them is expensive, time-consuming and can have negative effects on native biota. It recent years, the marine environment has seen an increase in recreational boating, international shipping and aquaculture but to date only the latter two have received international attention. In 2008 legislation changed to prohibit the use …
The Mitochondrial Permeability Transition Pore Components, Zoltan Mohar
The Mitochondrial Permeability Transition Pore Components, Zoltan Mohar
The Plymouth Student Scientist
The mitochondrial permeability transition pore (MPTP) is a non-specific channel in the inner mitochondrial membrane (IMM) that opens following ischaemia and reperfusion due to the presence of various stimuli, such as oxidative stress, elevated phosphate concentration, and adenine nucleotide depletion. MPTP opening causes the mitochondria to swell and become dysfunctional. This results in cell death, especially by necrosis, due to the loss of oxidative phosphorylation and the subsequent drop in adenosine triphosphate levels. In search of the identity of the pore numerous studies have been done by several research groups in the last three decades. For many years a widely …
Characteristics Of Wool Fibres From Mule Sheep, Nicola Bishop
Characteristics Of Wool Fibres From Mule Sheep, Nicola Bishop
The Plymouth Student Scientist
A study was conducted to find out if there were any differences in the characteristics of wool fibres from mule sheep in sheep of different ages. Wool samples were taken from 91 North of England Mule Sheep from Seale Hayne Farm in Newton Abbot, Devon. The hypothesis tested was that there are no differences in the characteristics of wool fibres (greasy weight, clean weight, dirt content, mean length and mean diameter) due to the age of the sheep. The age of each sheep was determined by the number of pairs of incisor teeth located on their lower jaw according to …
The Mechanisms Of Marine Bacterial Interactions, Grace Phillips
The Mechanisms Of Marine Bacterial Interactions, Grace Phillips
The Plymouth Student Scientist
Bacteria are found in numerous habitats within the vast marine realm. Many marine bacteria live together as a biofilm which allows them to closely interact and intimately influence each other‟s lives, mainly by the production of extracellular compounds such as antibiotics and exopolysaccharides. Coordination of the biofilm and communication between bacteria is controlled by a mechanism known as quorum sensing in which signal molecules called autoinducers are released and detected, resulting in an alteration of behaviour. These activities ultimately have implications on other organisms; controlling populations of invertebrates and algae, and affecting the health of eukaryotes, a major cause for …
Abundance And Diversity Of Anuran Species In Danum Valley, Sabah, Borneo, Abigail Porter
Abundance And Diversity Of Anuran Species In Danum Valley, Sabah, Borneo, Abigail Porter
The Plymouth Student Scientist
1. Anurans are important components of tropical ecosystems; however, the biodiversity of these species is under threat due to the rapid deforestation of Southeast Asian forests. 2. Abundances and numbers of individuals of anuran species from three different sites were surveyed. One site being that of a relatively undisturbed primary Dipterocarp forest, the other two being disturbed habitats, a secondary forest recovering from logging and a drainage ditch which has formed a pool site. 3. Species abundance and numbers of individuals was significantly different P<0.05 between the three sites. The primary forest site showed higher mean abundances of species and individuals of anuran species, with the secondary forest having the lowest abundances and the pool site having an intermediate value. 4. Variables of temperature and light levels were shown to have an impact upon frog species, with the highest temperatures and light readings found in the sites with less species and individuals. pH was neutral for all three sites so was not seen as a consequence effecting anurans. 5. The differences in anuran abundances and species in the three sites may indicate that environmental factors may be having detrimental impacts on anurans. 6. The need to census amphibians has never been more urgent than it is now. Among herpetologists, there is a growing awareness that amphibians are declining and becoming extinct in many parts of the world.
The Microbial Role In Carbon Cycling Within Seagrass Sediments, Heather Guy
The Microbial Role In Carbon Cycling Within Seagrass Sediments, Heather Guy
The Plymouth Student Scientist
Seagrasses are an important feature of coastal systems worldwide, capable of fixing significant amounts of carbon dioxide from the atmosphere into cellular material, potentially helping to alleviate rising carbon dioxide levels. However, the capacity of seagrass beds to act as carbon sinks is largely dependent on the amount of organic matter accumulated within the sediments following transformations by the microbial community. The microbial role in carbon cycling within seagrass sediments has been poorly researched, most likely because the importance of marine microbes in ocean cycling processes was only recently recognized, due to key advancements in molecular biology. This review examines …
Mollusk Species At A Pliocene Shelf Whale Fall (Orciano Pisano, Tuscany), S Danise, S Dominici, U Betocchi
Mollusk Species At A Pliocene Shelf Whale Fall (Orciano Pisano, Tuscany), S Danise, S Dominici, U Betocchi
School of Geography, Earth and Environmental Sciences
The recovery of an intact, 10 m long fossil baleen whale from the Pliocene of Tuscany (Italy) offers the first opportunity to study the paleoecology of a fully developed, natural whale-fall community at outer shelf depth. Quantitative data on mollusk species from the whale fall have been compared with data from the sediments below and around the bones, representing the fauna living in the muddy bottom before and during the sinking of the carcass, but at a distance from it. Although the bulk of the fauna associated with the fossil bones is dominated by the same heterotrophs as found in …
Effects Of Trace Metals On Cellular Immune Responses, Tissue Injury And Gene Expression In The Mussell, Mytilus Edulis: Implications For Biological Monitoring Of Marine Pollution., Sherin Khalifa Hadda Sheir
Effects Of Trace Metals On Cellular Immune Responses, Tissue Injury And Gene Expression In The Mussell, Mytilus Edulis: Implications For Biological Monitoring Of Marine Pollution., Sherin Khalifa Hadda Sheir
School of Biological and Marine Sciences Theses
The immunotoxic effects of trace metal exposure in bivalves are poorly understood and whether or not stimulation of the immune system exacerbates metal toxicity is still unclear. The mussel, Mytilus edulis, was exposed to 50 or 500 µg 1̵¹ total Hg or 20 0r 50 µg 1̵¹ total Cd for up to 11 days compared to no added Hg or Cd controls.
Rapid Microsatellite Isolation From A Butterfly By De Novo Transcriptome Sequencing: Performance And A Comparison With Aflp-Derived Distances, As Mikheyev, T Vo, B Wee, Mc Singer, C Parmesan
Rapid Microsatellite Isolation From A Butterfly By De Novo Transcriptome Sequencing: Performance And A Comparison With Aflp-Derived Distances, As Mikheyev, T Vo, B Wee, Mc Singer, C Parmesan
School of Biological and Marine Sciences
BACKGROUND: The isolation of microsatellite markers remains laborious and expensive. For some taxa, such as Lepidoptera, development of microsatellite markers has been particularly difficult, as many markers appear to be located in repetitive DNA and have nearly identical flanking regions. We attempted to circumvent this problem by bioinformatic mining of microsatellite sequences from a de novo-sequenced transcriptome of a butterfly (Euphydryas editha). PRINCIPAL FINDINGS: By searching the assembled sequence data for perfect microsatellite repeats we found 10 polymorphic loci. Although, like many expressed sequence tag-derived microsatellites, our markers show strong deviations from Hardy-Weinberg equilibrium in many populations, and, in some …
Modelling Visual Neglect: Computational Insights Into Conscious Perception, Lj Lanyon, Sl Denham
Modelling Visual Neglect: Computational Insights Into Conscious Perception, Lj Lanyon, Sl Denham
School of Psychology
BACKGROUND: Visual neglect is an attentional deficit typically resulting from parietal cortex lesion and sometimes frontal lesion. Patients fail to attend to objects and events in the visual hemifield contralateral to their lesion during visual search. METHODOLOGY/PRINCIPAL FINDING: The aim of this work was to examine the effects of parietal and frontal lesion in an existing computational model of visual attention and search and simulate visual search behaviour under lesion conditions. We find that unilateral parietal lesion in this model leads to symptoms of visual neglect in simulated search scan paths, including an inhibition of return (IOR) deficit, while frontal …
Herpetological Observations From Field Expeditions To North Karnataka And Southwest Maharashtra, India, T Lewis, S Piggott, R Griffin, P Grieg-Smith, G Martin, G Barretto, K Bajibab, C Thorpe, P Prodromou, M Fordham, D Willis, J Turner, A Radanovic, D Holloway, R Wood, N Hand, S Lloyd, M Clapson, J Hennesy, G Oldham
Herpetological Observations From Field Expeditions To North Karnataka And Southwest Maharashtra, India, T Lewis, S Piggott, R Griffin, P Grieg-Smith, G Martin, G Barretto, K Bajibab, C Thorpe, P Prodromou, M Fordham, D Willis, J Turner, A Radanovic, D Holloway, R Wood, N Hand, S Lloyd, M Clapson, J Hennesy, G Oldham
School of Biological and Marine Sciences
The Western Ghats of India are one of the 34 global hotspots of biodiversity. They are one of the most important large natural areas in the world and are fast becoming recognised for their biological importance. The herpetofauna of the Western Ghats is hugely diverse, with many species exhibiting rare, endemic styles of autecology and niche preference that could equal that of countries such as Borneo and Madagascar. In this report we detail 18 amphibian and 37 reptile species from eight sites following three expeditions to the Western Ghats from 2007-2009. The report details species descriptions, habitat, ecology and conservation …
Using Volcanic Marine Co2 Vents To Study The Effects Of Ocean Acidification On Benthic Biota: Highlights From Castello Aragonese D’Ischia (Tyrrhenian Sea), Mc Gambi, Jm Hall-Spencer, M Cigliano, S Cocito, C Lombardi, M Lorenti, Fp Patti, L Porzio, R Rodolfo-Metalpa, Mc Scipione, Mc Buia
Using Volcanic Marine Co2 Vents To Study The Effects Of Ocean Acidification On Benthic Biota: Highlights From Castello Aragonese D’Ischia (Tyrrhenian Sea), Mc Gambi, Jm Hall-Spencer, M Cigliano, S Cocito, C Lombardi, M Lorenti, Fp Patti, L Porzio, R Rodolfo-Metalpa, Mc Scipione, Mc Buia
School of Biological and Marine Sciences
Current research into ocean acidification is mainly being carried out using short-term experiments whereby CO2 levels are manipulated in aquaria and enclosures. We have adopted a new approach in our studies of the effects of ocean acidification on Mediterranean marine biodiversity by using volcanic carbon dioxide vent systems as ‘natural laboratories’ as they cause long-term changes in seawater carbonate chemistry. A range of organisms, including macroalgae, seagrasses, invertebrates, and selected scleractinians and bryozoans have now been investigated in a shallow area located off the island of Ischia (Castello Aragonese, Tyrrhenian Sea, Italy). Our in situ observations give support to concerns, …
Background Document For Maerl, Jm Hall-Spencer, J Kelly, Ca Maggs
Background Document For Maerl, Jm Hall-Spencer, J Kelly, Ca Maggs
School of Biological and Marine Sciences
No abstract provided.
Grounding Language In Action And Perception: From Cognitive Agents To Humanoid Robots, A Cangelosi
Grounding Language In Action And Perception: From Cognitive Agents To Humanoid Robots, A Cangelosi
School of Engineering, Computing and Mathematics
In this review we concentrate on a grounded approach to the modeling of cognition through the methodologies of cognitive agents and developmental robotics. This work will focus on the modeling of the evolutionary and developmental acquisition of linguistic capabilities based on the principles of symbol grounding. We review cognitive agent and developmental robotics models of the grounding of language to demonstrate their consistency with the empirical and theoretical evidence on language grounding and embodiment, and to reveal the benefits of such an approach in the design of linguistic capabilities in cognitive robotic agents. In particular, three different models will be …
The Mediterranean Sea Regime Shift At The End Of The 1980s, And Intriguing Parallelisms With Other European Basins, A Conversi, S Fonda Umani, T Peluso, Et Al
The Mediterranean Sea Regime Shift At The End Of The 1980s, And Intriguing Parallelisms With Other European Basins, A Conversi, S Fonda Umani, T Peluso, Et Al
School of Biological and Marine Sciences
BACKGROUND: Regime shifts are abrupt changes encompassing a multitude of physical properties and ecosystem variables, which lead to new regime conditions. Recent investigations focus on the changes in ecosystem diversity and functioning associated to such shifts. Of particular interest, because of the implication on climate drivers, are shifts that occur synchronously in separated basins. PRINCIPAL FINDINGS: In this work we analyze and review long-term records of Mediterranean ecological and hydro-climate variables and find that all point to a synchronous change in the late 1980s. A quantitative synthesis of the literature (including observed oceanic data, models and satellite analyses) shows that …
Cbd & D9-Thc - The Two Faces Of Cannabis, N/A Zeissler, Cb Carroll, J Zajicek
Cbd & D9-Thc - The Two Faces Of Cannabis, N/A Zeissler, Cb Carroll, J Zajicek
Peninsula Medical School
Cannabidiol (CBD) and D9-tetrahydrocannabinol (D9-THC) are phytocannabinoids produced by the plant Cannabis sativa which have both shown promising therapeutic value as anti-inflammatory and neuroprotective agents in a variety of neurological disorders. However, the molecular mechanisms involved in their protective function are thought to be distinctly different probably due to their divergent receptor pharmacology. D9-THC is a potent agonist at the cannabinoid receptors 1 and 2 through which it is thought to modulate synaptic plasticity and inflammatory responses respectively. CBD on the other hand exhibits negligible affinity for both receptors prompting research into cannabinoid receptor independent mechanisms of action such as …
Cbd & D9-Thc - The Two Faces Of Cannabis, Zeissler, Cb Carroll, J Zajicek
Cbd & D9-Thc - The Two Faces Of Cannabis, Zeissler, Cb Carroll, J Zajicek
Peninsula Medical School
Cannabidiol (CBD) and D9-tetrahydrocannabinol (D9-THC) are phytocannabinoids produced by the plant Cannabis sativa which have both shown promising therapeutic value as anti-inflammatory and neuroprotective agents in a variety of neurological disorders. However, the molecular mechanisms involved in their protective function are thought to be distinctly different probably due to their divergent receptor pharmacology. D9-THC is a potent agonist at the cannabinoid receptors 1 and 2 through which it is thought to modulate synaptic plasticity and inflammatory responses respectively. CBD on the other hand exhibits negligible affinity for both receptors prompting research into cannabinoid receptor independent mechanisms of action such as …
Multiple Grasp-Specific Representations Of Tool Dynamics Mediate Skillful Manipulation, James N. Ingram, Ian S. Howard, J. Randall Flanagan, Daniel M. Wolpert
Multiple Grasp-Specific Representations Of Tool Dynamics Mediate Skillful Manipulation, James N. Ingram, Ian S. Howard, J. Randall Flanagan, Daniel M. Wolpert
School of Engineering, Computing and Mathematics
No abstract provided.
Recruit-Recruit Interactions, Density-Dependent Processes And Population Persistence In The Eastern Oyster, Crassostrea Virginica, Am Knights, K Walters
Recruit-Recruit Interactions, Density-Dependent Processes And Population Persistence In The Eastern Oyster, Crassostrea Virginica, Am Knights, K Walters
School of Biological and Marine Sciences
The supply and successful settlement of larvae is vital for the development and persistence of populations of many marine species. Strongly influenced by hydrodynamic processes, the rate of supply affects the interaction between recruits. Population structure is determined by densityindependent mortality when recruitment is limited, and by density-dependent mortality when saturated; however, the extent to which these processes determine population structure remains unclear. The relationship between recruitment and density-dependent processes in population persistence was examined in South Carolina for the eastern oyster Crassostrea virginica. Over a range of recruit densities, the resultant change in population structure was compared at locations …
Genome-Wide Association Study Of Cnvs In 16,000 Cases Of Eight Common Diseases And 3,000 Shared Controls, The Wellcome Trust Case Control Consortium
Genome-Wide Association Study Of Cnvs In 16,000 Cases Of Eight Common Diseases And 3,000 Shared Controls, The Wellcome Trust Case Control Consortium
School of Biomedical Sciences
Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed approximately 19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated approximately 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. …
Report Of The Ices/Nafo Joint Working Group On Deep-Water Ecology (Wgdec), Jm Hall-Spencer
Report Of The Ices/Nafo Joint Working Group On Deep-Water Ecology (Wgdec), Jm Hall-Spencer
School of Biological and Marine Sciences
No abstract provided.
Biomimetics Learning From Nature, H Le, Ca Wang, Y Huang
Biomimetics Learning From Nature, H Le, Ca Wang, Y Huang
School of Biological and Marine Sciences
No abstract provided.
A Five‐Gene Signature As A Potential Predictor Of Metastasis And Survival In Colorectal Cancer, J Hao, J Chen, H Sui, X Si‐Ma, Et Al
A Five‐Gene Signature As A Potential Predictor Of Metastasis And Survival In Colorectal Cancer, J Hao, J Chen, H Sui, X Si‐Ma, Et Al
School of Biomedical Sciences
To understand the molecular mechanisms of metastasis and prognosis of colorectal cancer (CRC), we isolated single cell-derived progenies (SCPs) from SW480 cells in vitro and compared their metastatic potential in an orthotopic CRC tumour model in vivo. Two groups of SCPs with the capability of high and low metastasis, respectively, were obtained. By analysing the gene expression profiles of high (SCP51), low (SCP58) metastatic SCPs, and their parental cell line (SW480/EGFP), we demonstrated that 143 genes were differentially expressed either between SCP51 and SCP58 or between SCP58 and SW480/EGFP. Gene-annotation enrichment analysis of DAVID revealed 80 genes in the top …
Universal Features Of Post-Transcriptional Gene Regulation Are Critical For Plasmodium Zygote Development, Gr Mair, E Lasonder, Ls Garver, Bmd Franke-Fayard, Et Al
Universal Features Of Post-Transcriptional Gene Regulation Are Critical For Plasmodium Zygote Development, Gr Mair, E Lasonder, Ls Garver, Bmd Franke-Fayard, Et Al
School of Biomedical Sciences
A universal feature of metazoan sexual development is the generation of oocyte P granules that withhold certain mRNA species from translation to provide coding potential for proteins during early post-fertilization development. Stabilisation of translationally quiescent mRNA pools in female Plasmodium gametocytes depends on the RNA helicase DOZI, but the molecular machinery involved in the silencing of transcripts in these protozoans is unknown. Using affinity purification coupled with mass-spectrometric analysis we identify a messenger ribonucleoprotein (mRNP) from Plasmodium berghei gametocytes defined by DOZI and the Sm-like factor CITH (homolog of worm CAR-I and fly Trailer Hitch). This mRNP includes 16 major …
In Situ Perturbation Experiments: Natural Venting Sites, Spatial/Temporal Gradients In Ocean Ph, Manipulative In Situ Pco2 Perturbations, Jp Barry, Jm Hall-Spencer, T Tyrell
In Situ Perturbation Experiments: Natural Venting Sites, Spatial/Temporal Gradients In Ocean Ph, Manipulative In Situ Pco2 Perturbations, Jp Barry, Jm Hall-Spencer, T Tyrell
School of Biological and Marine Sciences
No abstract provided.
Comparison Of Two Storage Methods For The Analysis Of Cholinesterase Activities In Food Animals, Ka Askar, Ac Kudi, Aj Moody
Comparison Of Two Storage Methods For The Analysis Of Cholinesterase Activities In Food Animals, Ka Askar, Ac Kudi, Aj Moody
School of Biological and Marine Sciences
Cholinesterases (ChE) are specialized carboxylic ester hydrolases that catalyse the hydrolysis of choline esters. They are classified into either acetylcholinesterase (AChE) or butyrylcholinesterase (BChE). Determination of ChE in the tissues is the appropriate tool for the diagnosis of organophosphorus and carbamate exposures. In general, a significant inhibition was seen in both AChE and BChE activities after 6 months of freezing at -80°C and after 3 months of freezing at -20°C. Linear regression of mean AChE and BChE was observed in all individual samples during the months of the two freezing methods. Bland and Altman plot of the ratios of the …