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Targeting Mertk On Tumour Cells And Macrophages: A Potential Intervention For Sporadic And Nf2-Related Meningioma And Schwannoma Tumours, Kevin Herrera Keane Jan 2025

Targeting Mertk On Tumour Cells And Macrophages: A Potential Intervention For Sporadic And Nf2-Related Meningioma And Schwannoma Tumours, Kevin Herrera Keane

Peninsula Medical School Theses

Although schwannomas and meningiomas are generally benign and slow-growing, the mass effect of either tumour within the nervous system causes life-altering symptoms. Individuals with NF2-related schwannomatosis may develop schwannomas and meningiomas, increasing tumour burden. The primary treatment for large or symptomatic schwannomas and meningiomas is surgical resection, which may not be suitable in cases involving tumours located near sensitive neuroanatomy or clinically vulnerable individuals. Not all schwannomas and meningiomas respond to alternative targeted treatments such as stereotactic radiosurgery or the vascular endothelial growth factor inhibitor bevacizumab. The main objective of this thesis was to investigate targeting of the receptor tyrosine …


Visual Thinking Informed By Repetition: A Practice-Based Methodology, Julia Heurling Jan 2025

Visual Thinking Informed By Repetition: A Practice-Based Methodology, Julia Heurling

School of Art, Design and Architecture Theses

This artistic research proceeds from the idea that visual thinking is thinking about images through images. It explores how ideas are instigated, developed, and articulated exclusively through visual elements from a practice-based perspective. The use of repetition as a method of thinking is rooted in my previous practice as a pattern designer. I consider this a cognitive process based on the assumption that repetition is a tool for abstraction, as it changes one’s perspective from the particular to the general. Abstraction, in this context, becomes a method for processing information (i.e. to think visually).My artistic practice is engaged in combining …


Ontological Machines: Subjectivity And Relational Desire In Immersive And Interactive Environments, Toby Chanter Jan 2025

Ontological Machines: Subjectivity And Relational Desire In Immersive And Interactive Environments, Toby Chanter

School of Art, Design and Architecture Theses

This practice-based artistic research focuses on two contemporary spaces; namely the pedagogical spaces of healthcare Simulation Based Education (SBE), and the exhibition spaces of installation art. These seemingly unrelated activities share a range of technological and operational similarities that render their combined study under the banner of ‘immersive and interactive environments’ both novel and necessary. The lack of broad engagement with questions of representation, aesthetics, and affect is conspicuous in an educational practice that is reliant on, and implemented through, a network of overtly visual mediums, material technologies, and sensory modalities. In healthcare SBE, clinical skills are acquired, and medical …


Above And Below The Horizon: A Practice-Led Investigation Into Liminal Thresholds Of Bodies Of Water, Rachael Allain Jan 2025

Above And Below The Horizon: A Practice-Led Investigation Into Liminal Thresholds Of Bodies Of Water, Rachael Allain

School of Art, Design and Architecture Theses

This thesis contributes to the debate on the interactions between art, science, and phenomenological experience, whilst offering new possibilities for investigation in this interdisciplinary field. The research investigated thresholds of the aquatic horizon; the outline in the distance where sky and water appear to coalesce. Artistic practice and critical discourse challenged and interrogated the intersection between analogue and digital, still and moving technologies, revealing aspects of the physical and conceptual horizons within and beyond the visible light spectrum. A range of theoretical concepts reconfigured my readings and interpretations of the phases of experience, through liminality and phenomenology. This provided a …


Un-Framing Transiting Trajectories: A ‘Beyond Disciplinary’ Approach To Curating In The Context Of Art And Science Discourse, Christina Ioanna Kazakou Jan 2025

Un-Framing Transiting Trajectories: A ‘Beyond Disciplinary’ Approach To Curating In The Context Of Art And Science Discourse, Christina Ioanna Kazakou

School of Art, Design and Architecture Theses

Abstract


Artist Designed Systems In Community Radio, Lucinda Guy Jan 2025

Artist Designed Systems In Community Radio, Lucinda Guy

School of Art, Design and Architecture Theses

Skylark is a full-time licensed radio station, founded by the author of this thesis. Since 2020 it has broadcast a continuous and ever-changing sound installation, rejecting the conventional radio schedules of presenters, programmes, music tracks, adverts etc. Its content is drawn from contributors within Dartmoor National Park, and includes oral histories, music, poems, field recordings, archive material and fragments of bespoke music. Skylark is also a public service and research project that intends to offer an innovative way forward for community radio in the UK. Such stations are intended to respond to their locations, include multiple voices, and be not-for-profit. …


An Exploration Of The Experiences And Factors Influencing Physical Activity In People With Parkinsons, Heather Hunter Jan 2025

An Exploration Of The Experiences And Factors Influencing Physical Activity In People With Parkinsons, Heather Hunter

School of Health Professions Theses

Abstract:Background: Physical activity plays a crucial role in enhancing the well-being and quality of life of people with Parkinsons. Despite substantial evidence supporting its benefits, people with Parkinson’s struggle to maintain an active lifestyle. This thesis explored the perspective of people with Parkinsons on their engagement in physical activity.Methodology: This research employed a person-centred approach, comprised of three sequential phases. Phase One: A systematic review utilising the JBI approach of meta-aggregation synthesised the best available qualitative evidence of people with Parkinson's' views and preferences regarding physical activity interventions. Phase Two: Constructive Grounded Theory was used to explore the beliefs, attitudes, …


The Role Of A Pelvic Orthotic In The Management Of Chronic Pregnancy-Related Pelvic Girdle Pain: A Feasibility Study And Validation Of A Novel Body Perception Measure, Bradley Halliday Jan 2025

The Role Of A Pelvic Orthotic In The Management Of Chronic Pregnancy-Related Pelvic Girdle Pain: A Feasibility Study And Validation Of A Novel Body Perception Measure, Bradley Halliday

School of Health Professions Theses

Chronic pregnancy-related pelvic girdle pain (PPGP) affects an estimated 10% of post-partum women and is typically recalcitrant to conservative management. One novel option to manage this is a customised Dynamic Elastomeric Fabric Orthosis (DEFO), however, currently non studies have evaluated the clinical and cost-effectiveness or acceptability of this orthotic in post-partum women. Further, the mechanism of action of this orthotic is unknown. One mechanism may be to impart an effect on the disturbed body perception, which preliminary evidence has demonstrated is affected in women with PPGP. Current understanding is limited by an absence of research into women with PPGP and …


The Role Of Oral Nitrate Reducing Bacteria In Cardiovascular Health: Impacts Of Diet And Exercise, Craig Clarke Jan 2025

The Role Of Oral Nitrate Reducing Bacteria In Cardiovascular Health: Impacts Of Diet And Exercise, Craig Clarke

School of Health Professions Theses

This thesis investigated the important role of oral bacteria in blood pressure regulation and vascular function through the NO3--NO2--NO pathway following exercise or dietary interventions. Study 1 examined the effect of antibacterial mouthwash on the oral microbiome and nitrate metabolism in vegetarians and omnivores. Notable alterations in bacterial composition were observed after mouthwash administration, including reductions in the Prevotella genus (from 27.7% to 9.6%, P = 0.001) and Actinomyces genus (from 9.5% to 5.7%, P = 0.001), along with decreases in Prevotella melaninogenica (from 18.1% to 6.2%, P = 0.001) and Rothia dentocariosa (from 0.09% to 0.04%, P = 0.001). …


The Revolving Door Of Epilepsy Emergencies, Sarah Lennard Jan 2025

The Revolving Door Of Epilepsy Emergencies, Sarah Lennard

School of Health Professions Theses

This thesis explores the revolving doors of epilepsy emergencies, focusing on the key factors that contribute to repeated attendances at emergency departments (ED) following seizures. The study is based on five peer-reviewed journal articles that provide a comprehensive review of current evidence, risk factors for ED attendance, clinicians' perspectives, and the use of technology in epilepsy management. The research identifies several critical factors influencing ED attendances, including mental health issues, medication adherence, and social determinants such as deprivation and homelessness. The findings highlight the need for integrated care pathways, improved communication between healthcare providers, and targeted interventions for vulnerable populations. …


A Critical Exploration Of Social Transformation Through Occupation, Miranda Cunningham Jan 2025

A Critical Exploration Of Social Transformation Through Occupation, Miranda Cunningham

School of Health Professions Theses

Background: In occupational therapy and occupational science, scholars and practitioners advocate for a stronger focus on social transformation. However, there is limited evidence on how occupation-based interventions contribute to addressing inequalities and fostering change for marginalised populations. Methods: This study applied critical occupational science and realist theoretical frameworks to examine the use of arts-based occupations for social transformation. It comprised three strands: (1) a narrative review of arts-based occupations in social change, (2) a realist review of participatory photography, and (3) a realist evaluation of a socially engaged art group in primary schools. Findings: Arts-based occupations have been employed by …


Investigating The Link Between The Oral Microbiome And Cardiovascular Health In Regards To Nitrate/Nitrite Metabolism., Lisa Du Toit Jan 2025

Investigating The Link Between The Oral Microbiome And Cardiovascular Health In Regards To Nitrate/Nitrite Metabolism., Lisa Du Toit

School of Health Professions Theses

This thesis evaluated nitrate metabolism and the link between cardiovascular health and periodontal disease. The first study compared effects of high-nitrate vegetables and pharmacological salt supplementation on the oral microbiome composition in hypertensive individuals. Seventy participants (50-70-y-old, clinical systolic BP (SBP) 130-159 mmHg, diastolic BP (DBP) <110 mmHg) were randomly allocated to group 1 (n = 24) consuming 300 mg/d nitrate in green leafy vegetables form, group 2 (n = 23) consuming 300 mg/d potassium nitrate in form of pills and low-nitrate vegetables, and group 3 (n = 23) consuming potassium chloride pills (placebo) and low-nitrate vegetables. Groups 1 and 2 showed similar microbial salivary changes, increased Neisseria species, and decreased Veillonella species post treatment, suggesting nitrate-dependent changes.The second study investigated oral health and microbiome composition of pregnant women with pre-eclampsia (n = 10, SBP = 150 ± 8 mmHg, DBP = 98 ± 9 mmHg) compared to normotensive pregnancies (n = 11, SBP = 111 ± 5 mmHg, DBP = 80 ± 9 mmHg). Pregnant women with pre-eclampsia showed higher plaque levels compared to normotensive pregnant women (P = 0.038), although activity of oral nitrate-reducing bacteria (P = 0.088) was not statistically significant. Plasma nitrate levels were significantly were lower in women with pre-eclampsia (P = 0.024). The third study evaluated the effect of chlorhexidine (CHX-M n= 21) and propolis (PROP-M n= 24) mouthwashes on abundance and activity of nitrate-reducing bacteria in healthy individuals. CHX-M increased relative abundance of nitrate-reducing bacteria (P < 0.001), but significantly impaired nitrate-reducing activity (P < 0.001) compared to baseline and PROP-M. PROP-M significantly increased plasma nitrate levels (P = 0.047) and reduced systolic BP (P = 0.022).The fourth study compared the effect of CHX-M, PROP-M, amoxicillin (AMX) and metronidazole (MTZ) on salivary nitrate-reducing activity within a 24-hour period using an in-vitro protocol. Results showed that MTZ significantly increased nitrate-reducing activity after 24-hours (P = 0.001) compared to all the other treatments (AMX, P = 0.025; CHX-M, P = 0.01; PROP-M, P = 0.023). Overall, this thesis suggests that poor oral health may impair the oral nitrate–nitrite pathway, thereby reducing nitrate bioavailability in women with pre-eclampsia. Diets rich in high-nitrate vegetables showed beneficial changes in the oral microbiome; however, these were not associated with blood pressure reduction. In contrast, use of propolis mouthwash increased plasma nitrate bioavailability, contributing to blood pressure reductions. Finally, it was observed metronidazole significantly enhanced nitrate-reducing activity.


Factors Affecting Metabolism And Metabolic Control In Phenylketonuria, Alex Amorim Pinto Jan 2025

Factors Affecting Metabolism And Metabolic Control In Phenylketonuria, Alex Amorim Pinto

School of Health Professions Theses

Phenylketonuria (PKU) is an inherited metabolic disorder treated by a phenylalanine restricted diet in order to avoid neurocognitive impairment. Blood phenylalanine is the main outcome marker which is modulated by many dietary factors. Traditionally, L-amino acid-based protein substitutes are the main nitrogen source but more recently glycomacropeptide-based protein substitutes (GMP) have been introduced and are associated with several health benefits. The following aspects were studied in this thesis: 1) metabolic control achieved in patients with PKU compared with the European PKU guidelines; 2) life-long change in natural protein tolerance; 3) impact on metabolic control of different natural protein sources (animal …


A Computational Fluid Dynamics (Cfd) Based Assessment Of Animal Borne Data Logger Impact, Christopher Pass Jan 2025

A Computational Fluid Dynamics (Cfd) Based Assessment Of Animal Borne Data Logger Impact, Christopher Pass

School of Engineering, Computing and Mathematics Theses

Animal borne data loggers are powerful tools that provide researchers with valuable insight into the behaviour and ecology of free-ranging marine animals. Despite their usefulness, the addition of a tag inevitably alters the forces acting on a swimming body and can increase the energetic cost of swimming. Computational Fluid Dynamics (CFD) tools offer a powerful means of assessing tag impact and a number of previous works have employed CFD to this end but have typically been based on a range of simplifying assumptions. Chief amongst these simplifications is that animals can be modelled as rigid bodies with a simple tag …


Graphene Biosensors For The Detection Of Alzheimer's And Cardiovascular Disease Protein Biomarkers, Theodore Bungon Jan 2025

Graphene Biosensors For The Detection Of Alzheimer's And Cardiovascular Disease Protein Biomarkers, Theodore Bungon

School of Engineering, Computing and Mathematics Theses

Dementia describes a syndrome or group of symptoms associated with the decline of brain functioning such as loss of memory, mood, judgment, language, thinking speed, mental sharpness and other mental abilities. Different classes of Dementia are Jakob Disease, Korsakoff Syndrome, Vascular dementia, Parkinson’s disease, Huntington disease, young onset dementia, Alzheimer’s disease (AD) etc. At present, AD is irreversible and incurable, and it worsens overtime, it is neurodegenerative, caused by the accumulation or build-up of abnormal protein in the brain. It is a type of dementia that is common, affecting about 60% of patients with dementia diagnosis. Globally, over 54 million …


Anomaly Detection Based Post Gripping Perception For Industrial Logistics Robotics, Firas Zoghlami Jan 2025

Anomaly Detection Based Post Gripping Perception For Industrial Logistics Robotics, Firas Zoghlami

School of Engineering, Computing and Mathematics Theses

The adoption of low volume high mix manufacturing lines in global production sites has lead to a great need for flexible automation solutions. Flexible intelligent robots as an example are increasingly deployed in new industrial environments, such as the intra-logistics, in order to increase the automation level of the mentioned manufacturing lines. The lack of structure and the high dynamic of such industrial environments lead to potential performance deterioration related to unexpected events that are not recognized by the robot. Detecting such changes in the robot environment is believed in this thesis to be possible with anomaly detection techniques which …


Cold Water Swimming And Pregnancy: A Scoping Review And Consensus Recommendations, J. Shawe, M. Felton, J. C. Harper, C. Mark Harper, R. Stidson, M. Tipton, S. Blowers, K. Fraser, S. Hingley, E. Mcgrath, G. Bainbridge, Massey Heather Jan 2025

Cold Water Swimming And Pregnancy: A Scoping Review And Consensus Recommendations, J. Shawe, M. Felton, J. C. Harper, C. Mark Harper, R. Stidson, M. Tipton, S. Blowers, K. Fraser, S. Hingley, E. Mcgrath, G. Bainbridge, Massey Heather

School of Nursing and Midwifery

Introduction: Cold water swimming has increased in popularity and women wish to swim throughout pregnancy. There is a lack of evidenced-based guidance to make decisions about the safety of immersion in cold water during pregnancy. Methods: Closed social media groups were asked for specific questions in relation to cold water swimming and pregnancy. This highlighted concerns including water temperature, risks to the mother and fetus, and water quality. To find evidence-based answers, a series of meetings brought together clinicians and researchers with expertise in cold water physiology, exercise physiology, fertility, obstetrics, neonatology, midwifery, water epidemiology, public health and representatives from …


‘At Least I Wasn't In An Inner-City Flat With A Partner I Hated’: An Auto/Biographical Study Of Reflections On Well-Being By 35-65 Year Olds In Cornwall Following The Covid-19 Pandemic, Cheralyn May Jan 2025

‘At Least I Wasn't In An Inner-City Flat With A Partner I Hated’: An Auto/Biographical Study Of Reflections On Well-Being By 35-65 Year Olds In Cornwall Following The Covid-19 Pandemic, Cheralyn May

School of Law, Humanities and Social Sciences Theses

The effects of the Covid-19 pandemic on mental health have been considerably researched since its start in 2019, by researchers from a range of disciplines around the world. This sociological study (using insights from social and positive psychology) contributes to our knowledge of the pandemic by using qualitative methods – fourteen semi-structured interviews and researcher auto/biography to investigate the mental health experiences of middle-aged, single adults living in Cornwall in the UK during the pandemic. In the pandemic literature, this is an under-researched, and therefore potentially less understood, group and location. The data was analysed using a combination of the …


Reducing Marine Plastic Pollution: Critical Assessment Of The Potential To Develop A Civil Liability And Compensation Mechanism Under The Law Of The Sea Convention, Alexandra Leaton Jan 2025

Reducing Marine Plastic Pollution: Critical Assessment Of The Potential To Develop A Civil Liability And Compensation Mechanism Under The Law Of The Sea Convention, Alexandra Leaton

School of Law, Humanities and Social Sciences Theses

Plastic pollution has had a detrimental global impact, particularly in the marine environment, due to its mobility, longevity, and tendency to be difficult to retrieve. The situation has worsened because of the increased production and consumption of plastics and the fact that pollution occurs throughout the entirety of plastics’ production and lifecycle. Its pathways/vectors to the marine environment are diffuse and complex. The combined environmental, social, and potential health impacts of plastics have resulted in the development of over 40 international legal and other regulatory mechanisms, although inconsistent implementation has resulted in a fragmented framework with gaps and overlaps. The …


Transient Lives: Trans & Non-Binary People’S Encounters With The Harms Of Work, Siggi Auerbach Jan 2025

Transient Lives: Trans & Non-Binary People’S Encounters With The Harms Of Work, Siggi Auerbach

School of Law, Humanities and Social Sciences Theses

This ethnographic criminological research aimed to address several theoretical gaps in the existing literature surrounding trans people, vulnerability, and victimisation. The overarching objective of this study was to offer a revised account of the harms trans people encounter in relation to their work via a new theoretical framework which is informed by ultra-realist criminology, critical hate studies. The theoretical framework was informed by contemporary criminologies of the harms of work, as opposed to the harms the institution of work is argued to inflict upon intersectional aspects of the individual’s social identity. This thesis aimed to reconceptualise the harms trans workers …


Numerical Modelling Of Gravel Transportation By A Tsunami With The Extended Xbeach-G, Masashi Watanabe, Gerd Masselink, Daisuke Ishimura, Masaki Yamada, Adam D. Switzer Jan 2025

Numerical Modelling Of Gravel Transportation By A Tsunami With The Extended Xbeach-G, Masashi Watanabe, Gerd Masselink, Daisuke Ishimura, Masaki Yamada, Adam D. Switzer

School of Biological and Marine Sciences

Estimating coastal erosion by a tsunami is essential for land use planning, assessing hazards for current structures (e.g., coastal nuclear power plants), and for paleotsunami reconstruction. Such estimations are currently available only for sandy beaches, using sand sediment transport models, which are not applicable to gravel beaches, which are the most common beach type in high-latitude settings. This study extended the one-dimensional cross-shore XBeach-G model to account for two-dimensional gravel transport by a tsunami. First, this study confirmed that the extended XBeach-G model can simulate a time series of waveforms of solitary waves during laboratory experiments. The proposed model was …


Climate Adaptation For A Natural Atoll Island In The Maldives - Predicting The Long-Term Morphological Response Of Coral Islands To Sea Level Rise And The Effect Of Hazard Mitigation Strategies, F. E. Roelvink, G. Masselink, C. Stokes, R. T. Mccall Jan 2025

Climate Adaptation For A Natural Atoll Island In The Maldives - Predicting The Long-Term Morphological Response Of Coral Islands To Sea Level Rise And The Effect Of Hazard Mitigation Strategies, F. E. Roelvink, G. Masselink, C. Stokes, R. T. Mccall

School of Biological and Marine Sciences

Coral atoll islands, common in (sub)tropical oceans, consist of low-lying accumulations of carbonate sediment produced by fringing coral reef systems and are of great socio-economic and ecological importance. Previous studies have predicted that many atoll islands will become uninhabitable before the end of this century due to sea level rise exacerbating wave-driven flooding. However, the assumption that such islands are morphologically static has been challenged by observations and modeling that show the potential for overwashing and sediment deposition to maintain island freeboard. Reliable long-term predictions of island change and future flood risk, essential for adaptation planning, are, however, lacking. Here, …


Globalism, Localism And Blue Food Systems – How Can Cross-Scale Tensions Be Reduced? A Production Perspective From Uk Seafood Stakeholders, Alex J. Caveen, Bryce D. Stewart, Cameron Moffat, Daniel Skerritt, Estelle Jones, Huw Thomas, Lara Funk, Magnus Johnson, Mike Cohen, Michael Roach, Neil A. Auchterlonie, Samuel Peacock, Sarah Hussey, Tim Gray, Tom Pickerell, Umi Muawanah, Vasiliki Kioupi, Yvonne Sadovy De Mitcheson, Neil M. Burns, Charlotte R. Hopkins Jan 2025

Globalism, Localism And Blue Food Systems – How Can Cross-Scale Tensions Be Reduced? A Production Perspective From Uk Seafood Stakeholders, Alex J. Caveen, Bryce D. Stewart, Cameron Moffat, Daniel Skerritt, Estelle Jones, Huw Thomas, Lara Funk, Magnus Johnson, Mike Cohen, Michael Roach, Neil A. Auchterlonie, Samuel Peacock, Sarah Hussey, Tim Gray, Tom Pickerell, Umi Muawanah, Vasiliki Kioupi, Yvonne Sadovy De Mitcheson, Neil M. Burns, Charlotte R. Hopkins

School of Biological and Marine Sciences

‘Blue foods’ are derived from aquatic species that are caught or cultivated and are amongst the most globally traded commodities. Growing emphasis is being placed on blue foods in future transitions to sustainable food systems. However, recent international events such as the Covid-19 pandemic, UK-EU ‘Brexit’, and Russia-Ukraine war have caused renewed interest in ideological debates between globalism and localism and associated cross-scale tensions. Here, we aim to provide further insight into cross-scale tensions in blue food systems through a literature review and UK-based seafood stakeholder workshop. From our literature review, the evidence for cross-scale tensions was linked to the …


Measuring Juvenile Habitat Quality For Fishes And Invertebrates, Benjamin J. Ciotti, Elliot J. Brown, Francesco Colloca, David B. Eggleston, A. Challen Hyman, Olivier Le Pape, Romuald N. Lipcius, Margot A. M. Maathuis, Suzanne S. H. Poiesz, Kenneth A. Rose, Rochelle D. Seitz, Daniele Ventura, Karen E. Van De Wolfshaar Jan 2025

Measuring Juvenile Habitat Quality For Fishes And Invertebrates, Benjamin J. Ciotti, Elliot J. Brown, Francesco Colloca, David B. Eggleston, A. Challen Hyman, Olivier Le Pape, Romuald N. Lipcius, Margot A. M. Maathuis, Suzanne S. H. Poiesz, Kenneth A. Rose, Rochelle D. Seitz, Daniele Ventura, Karen E. Van De Wolfshaar

School of Biological and Marine Sciences

Identifying the role of marine and estuarine habitats in supporting fish and invertebrate populations during vulnerable juvenile life stages is essential to achieve effective conservation and fisheries management. There remains general agreement that: (i) the quality of juvenile habitat is best measured as the contribution of juveniles to adult populations (here “juvenile–adult contribution”) and (ii) this contribution may be measured directly or inferred from habitat-specific abundance, growth and survival. Obtaining effective estimates of juvenile habitat quality using these four metrics, however, is challenging. Through a systematic review of approaches to measure juvenile habitat quality, we critically evaluate current abilities to …


The Use Of An In Chemico Digestibility Assay To Reduce The In Vivo Fish Bioaccumulation Testing Of Nanomaterials, Craig Mchardy, Nathaniel J. Clark, Robert Clough, Richard D. Handy Jan 2025

The Use Of An In Chemico Digestibility Assay To Reduce The In Vivo Fish Bioaccumulation Testing Of Nanomaterials, Craig Mchardy, Nathaniel J. Clark, Robert Clough, Richard D. Handy

School of Biological and Marine Sciences

Currently for engineered nanomaterials (ENMs), there are no alternatives to bioaccumulation testing in fish as prescribed by OECD TG 305. New approaches are being sought, in order to reduce the numbers of animals used and address the ethical concerns associated with the use of vertebrates in such testing. This study aimed to demonstrate the value of an alternative method — the in chemico digestibility assay — as a tool to assess the bioaccumulation potential of ENMs. Titanium dioxide ENMs, or their equivalent bulk form, were incorporated onto a commercial fish diet and the fish digestion process was simulated in vitro …


Characterisation Of Tyre Wear Particle Transport From Road Runoff To Sea In Coastal Environments, Florence N.F. Parker-Jurd, Geoffrey D. Abbott, Daniel C. Conley, Cijo M. Xavier, Florian Pohl, Richard C. Thompson Jan 2025

Characterisation Of Tyre Wear Particle Transport From Road Runoff To Sea In Coastal Environments, Florence N.F. Parker-Jurd, Geoffrey D. Abbott, Daniel C. Conley, Cijo M. Xavier, Florian Pohl, Richard C. Thompson

School of Biological and Marine Sciences

Data on the fate of tyre wear particles (TWPs) within aquatic environments is limited. This study quantified TWPs entering estuaries in stormwater drainage and atmospheric fallout, and once they have reached the marine environment, within surface waters and sediments. TWPs were found at concentrations of 0.4 mg/L, 2.55 mg/m2/d, 0.00063 mg/L, and 0.96 g/kg respectively. Samples were partitioned by size to examine the distribution of TWP mass. 80-90% of TWP mass entering marine systems (stormwater and atmospheric fallout) lay between 31-125 µm. Larger particles preferentially accumulated in sediments where ∼50 % of TWP mass was >250 μm, compared to surface …


Stronger Shores: A Natural Capital Asset And Risk Register For The Northeast England Coastline Part Three: Application Of The Natural Capital Asset And Risk Register To Appraise Options And Assess Benefits Within Flood And Coastal Erosion Risk Management. A Report Has Been Compiled By Staff At The Marine Institute, School Of Biological And Marine Science, University Of Plymouth., Matthew Ashley, Helen Agosti, Tom Mullier, Tom Mullier, Riley Bibaud, Sian Rees Jan 2025

Stronger Shores: A Natural Capital Asset And Risk Register For The Northeast England Coastline Part Three: Application Of The Natural Capital Asset And Risk Register To Appraise Options And Assess Benefits Within Flood And Coastal Erosion Risk Management. A Report Has Been Compiled By Staff At The Marine Institute, School Of Biological And Marine Science, University Of Plymouth., Matthew Ashley, Helen Agosti, Tom Mullier, Tom Mullier, Riley Bibaud, Sian Rees

School of Biological and Marine Sciences

The Part Three report identifies the role and opportunity for application of the Natural Capital Asset and Risk Register evidence, provided in Reports Part One and Two, in appraisal of Nature-based Solutions (NbS) options within Flood and Coastal Erosion Risk Management (FCERM). Interventions applying NbS aim to increase extent and condition of specific habitat assets (ecosystem assets), therefore, considerable environmental benefits, as well as relevant cross-policy objectives are met when NbS are considered as an option. As such, the linked contribution to ecosystem services and associated benefits to people, and where possible economic value, needs to also be documented when …


Transgenerational Plasticity Research: Challenges And Opportunities, Caitlin Mcandry, Alastair J. Wilson, Peter A. Cotton, Manuela Truebano Jan 2025

Transgenerational Plasticity Research: Challenges And Opportunities, Caitlin Mcandry, Alastair J. Wilson, Peter A. Cotton, Manuela Truebano

School of Biological and Marine Sciences

Transgenerational plasticity (TGP) is a type of non-genetic inheritance whereby one generation's environment affects a subsequent generation's phenotype. It can influence the persistence of organisms in stressful climatic conditions through allowing rapid phenotypic change. TGP has been proposed to have the potential to alter an organism's response to selective forces or buffer their effects, yet the interaction of these two processes is neither well understood nor often accounted for via appropriate experimental design. The rapid expansion of TGP research in recent years has led to a lack of clarity surrounding terminology for different phenomena, sometimes undermining the interpretation of research. …


Electrical Characterization Of The Alleged Bio-Memristor Physarum Polycephalum, Markus Schmidt, Günter Seyfried, Uliana Reutina, Zeki Seskir, Eduardo R. Miranda Jan 2025

Electrical Characterization Of The Alleged Bio-Memristor Physarum Polycephalum, Markus Schmidt, Günter Seyfried, Uliana Reutina, Zeki Seskir, Eduardo R. Miranda

School of Art, Design and Architecture

This study investigates the potential of the slime mold Physarum polycephalum to function as a bio-memristor. In contrast to earlier reports, our experimental results did not show a significant memristive behavior. Instead, all tested slime molds exhibited elliptical I-V characteristics, attributed to their inherent capacitance. To model this behavior, we developed replacement circuits consisting solely of resistors and capacitors, which accurately reproduced the observed results. While these circuits lack memristive properties, they demonstrate potential utility as sub-circuits in analog applications, such as filters, timing circuits, and phase shift networks. Despite it not being a memristor, P. polycephalum may hold promise …


Balancing Nature And Tradition: Ocean Governance In The Noosa World Surfing Reserve, Kizzy Beaumont, Kirra Molnar, Michael Court Jan 2025

Balancing Nature And Tradition: Ocean Governance In The Noosa World Surfing Reserve, Kizzy Beaumont, Kirra Molnar, Michael Court

School of Art, Design and Architecture

Executive summary This report captures insights from focus groups and interviews held in Noosa in September 2024 as part of ongoing research into Transformative Ocean Governance. Participants shared reflections on the successes and struggles of the Noosa World Surfing Reserve (WSR) and outlined visions for its future.The WSR was praised for its cultural importance, environmental values, and grassroots leadership, but concerns were raised about crowding, tourism pressure, outdated policies, and fragmented governance. Participants highlighted gaps in environmental and surf-amenity data, funding shortages, and limited capacity to engage diverse community voices. Governance overlaps between the WSR, Council, and Biosphere Reserve have …