Digital Commons Network^™

Metabolic And Kinetic Impacts Of The Auxiliary Energy Source In Model Chemolithoheterotrophic Bacteria, Caleb Yarnley

School of Biological and Marine Sciences Theses

Chemolithoheterotrophy describes a type of microbial metabolism by which organisms oxidise an inorganic electron donor to supplement the generation of an electrochemical gradient. This results in higher overall growth yields and maximum specific growth rates as the organism does not need to generate as many reducing equivalents to fuel the respiratory chain and can instead redirect that material into anabolic reactions to generate more biomass. Many aspects of this metabolism remain poorly understood due to the difficulty in observing genuine chemolithoheterotrophy, with significant increases in the maximum specific growth yield (YMAX) and maximum specific growth rate (µMAX) seen in continuous …

Predictive Perception In Autism, Robert Harlow

School of Psychology Theses

This thesis investigates how predictive perception, motor coordination, and neurotype differences influences social perception in autism. It explores how these mechanisms contribute to social difficulties faced by autistic people, through the lens of the double empathy problem and second-person neuroscience.Chapter 2 examined how spoken intentions and visual evidence guide predictive social perception. Across four experiments, results supported a dual-process model whereby top-down expectations shape early perception but are overridden by visual input once motion begins. This led to the ‘kinematic dominance hypothesis’, suggesting motion cues dominate perception once movement begins due to their higher precision.Chapter 3 used high-resolution active motion …

Safe Space: A Novel And Accompanying Critical Study Into The Participatory Culture In Fandom And A Historiographic Approach To The Fragmentation Of Popular Culture In Select Novels By Kurt Vonnegut And Thomas Pynchon., Edward Whitfield

School of Law, Humanities and Social Sciences Theses

This research is submitted as both a novel and supplementary critical study. It explores the dynamic interplay between media consumers and content creators within the context of contemporary online critical discourse. The study is anchored by the novel Safe Space, a metamodern science fiction novel that explores the tension between progressive and orthodox ideologies within Anglo-American science fiction fandom – a symbolic battle in the Culture Wars.The investigation uses a historiographic, long durée (or long term) approach to test the hypothesis that periods of cultural anxiety are related to a loss of confidence in great hegemons. The research interrogates the …

Reassembling Anti-Oppressive Teaching Practices In Professionally Qualifying Youth And Community Work Education, Christine Smith

School of Law, Humanities and Social Sciences Theses

New and continuing formations of oppression remains a contemporary 21st Century challenge compounded by a fracturing of democratic structures that give rise to intolerance of difference and threaten social bonds. The big questions about the type of society we want to live in, what it means to be human, and the role of education are questions that are increasingly alienated from everyday lived experiences and a collective commitment to shape a fairer and more socially just world. Thus, the scale of challenges underscores a need to think differently about how Anti-Oppressive Practice (AOP) in professionally qualifying youth and community education …

“No One Told You Life Was Gonna Be This Way”: A Qualitative Exploration Of Friendship Expectations And Reality In University Life, Michael Priestley, Hannah Rachael Slack, Miss Madiha Islam, Delia Fuhrmann, Emily Long, Sarah Crook, Juliet Foster, Sophie Homer, Nicola Byrom

School of Psychology

Introduction: Young adulthood (ages 18–25) is a high-risk period for loneliness, particularly during educational transitions. Loneliness has negative consequences for mental health, physical health, and educational achievement. Psychologists conceptualize loneliness as emerging from a discrepancy between expected and experienced social connection, but this has been under-explored during young adulthood. Method: Drawing on thematic analysis of eight focus groups with 21 young adults in the UK, this paper explores the differences between retrospective expectations and experience of social connection during the transition into university and the implications for loneliness. Results: Whilst social expectations, experiences, and preferences vary considerably, young adults' perception …

Strabismus And Amblyopia Disrupt Spatial Perception But Not The Fidelity Of Cortical Maps In Human Primary Visual Cortex, D. Schluppeck, D. Arnoldussen, Z. Hussain, J. Besle, S. T. Francis, P. V. Mcgraw

School of Psychology

Amblyopia is a common disorder of spatial vision and is frequently associated with the presence of anisometropia, strabismus, or both, during visual development. For highly visible stimuli, subjects with strabismic amblyopia often report marked spatial distortions, but the neural basis of this supra-threshold deficit is not well understood. Here, we used a combination of behavioural measurements and visual field mapping with high spatial-resolution functional magnetic resonance imaging (fMRI) at 7 T to assess perceptual distortions in 12 participants with strabismic amblyopia and 9 control subjects. We measured both behavioural and cortical visual field maps monocularly through each eye. Although amblyopic …

Cross-Cultural Data On Romantic Love And Mate Preferences From 117,293 Participants Across 175 Countries, Marta Kowal, Piotr Sorokowski, Biljana Gjoneska, Katarzyna Pisanski, Gerit Pfuhl, Leonardo Aguilar, Steve M.J. Janssen, Benjamin Gelbart, Patrícia Arriaga, Jan Antfolk, Katarina Zvončáková, Linda H. Lidborg, Jorge Contreras-Garduño, Mikhail V. Kozlov, Taciano L. Milfont, Marco A.C. Varella, Valerija Križanić, Mahmoud Boussena, Tina Kavčič, Diana Ribeiro Da Silva, Brahim Hamdaoui, Fatima Zahra Sahli, Karlijn Massar, Eliane Deschrijver, Tatsunori Ishii, Hakan Cetinkaya, Oksana Senyk, Farida Guemaz, Koen Ponnet, Yahya Don

School of Psychology

Psychological studies on close relationships have often overlooked cultural diversity, dynamic processes, and potentially universal principles that shape intimate partnerships. To address the limited generalizability of previous research and advance our understanding of romantic love experiences, mate preferences, and physical attractiveness, we conducted a large-scale cross-cultural survey study on these topics. A total of 404 researchers collected data in 45 languages from April to August 2021, involving 117,293 participants from 175 countries. Aside from standard demographic questions, the survey included valuable information on variables relevant to romantic relationships: intimate, passionate, and committed love within romantic relationships, physical-attractiveness enhancing behaviors, gender …

Nitrate And Nitrite Bioavailability In Plasma And Saliva: Their Association With Blood Pressure - A Systematic Review And Meta-Analysis, Raul Bescos, Laura Gallardo-Alfaro, Ammar Ashor, Lucia Rizzolo-Brime, Mario Siervo, Patricia Casas-Agustench

School of Health Professions

In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO ₃ ⁻) and nitrite (NO ₂ ⁻) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19–74 years (males = 906; females = 1012), which measured plasma and/or salivary NO ₃ ⁻ and NO ₂ ⁻ using the chemiluminescence technique, were included. Mean plasma NO ₃ ⁻ and NO ₂ ⁻ concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower …

A Lifestyle Educational Course As An Adjunct To Biologic Administration In Patients With Severe Asthma: A Feasibility Study, Joseph W. Lanario, Drew Davies, Lucy Cartwright, Michael E. Hyland, Matthew Masoli

School of Health Professions

Objective: To assess the feasibility and acceptability of adapting a psychoeducation course (Body Reprogramming) for severe asthma and finding suggestions for improvement. Methods: Severe asthma patients were recruited from a single centre and enrolled in an online group-based course. Each course consisted of four sessions: introduction to BR, stress, exercise, and diet. Participants were asked to complete questionnaires assessing HRQoL, mood, asthma and extra-pulmonary symptoms, pre/post course. Those who attended two or more sessions were invited to provide feedback in interviews. Results: Twenty-eight participants took part in one of the five courses. Thirteen (46 %) attended all four sessions and …

Concordance Of Molecular Microbiology And Conventional Culture Techniques For Infected Diabetic Foot Ulcer Management, Angela Oates, Sarah T. Brown, Colin C. Everett, Fran Game, Jane E. Nixon, Tim Sloan, Michelle M. Lister, Michael Backhouse, Benjamin A. Lipsky, David Russell, Howard Collier, Joanna Dennett, Rachael Gilberts, E. Andrea Nelson, Jon Deeks, Sue Mallett, Roger Gasdby, Jane Lewis, Julie Brittenden, Andrew Bradbury, Joanne Paton, Zoe Hoare, Deborah Fitzsimmons, Mark Wilcox, Gerry Rayman, Brenda Riley, Christine Thomas, Ravikanth Gouni, Haroon Siddique, Gillian A. Lomax

School of Health Professions

Aim: The management of infected diabetic foot ulcers (DFUs) requires balancing the need for timely interventions against the desire for targeted antibiotic therapy, which relies on laboratory results. This study aimed to evaluate concordance between molecular and conventional culture and sensitivity (C&S) methods in identifying bacteria from infected DFUs. Methods: This study was conducted alongside CODIFI2, a Phase III randomised controlled trial comparing tissue sampling with wound swabbing. It assessed C&S and metagenomic 16S rRNA gene sequencing (M16S) in DFUs with suspected mild or moderate infections using both tissue and swab samples. Results: In 145 participants, C&S identified 248 microorganisms …

Sulfur Cycling In The Gabbroic Section Of The Oman Ophiolite, Ana P. Jesus, Harald Strauss, Mário A. Gonçalves, Michelle Harris, Diogo Silva, Martin J. Whitehouse, Damon A.H. Teagle

School of Geography, Earth and Environmental Sciences

We present sulfur mineralogy and isotope geochemistry from the gabbro transect of the Oman Drilling Project to unravel the sulfur cycle during hydrothermal alteration of the plutonic oceanic crust. The sheeted dike–gabbro transition (Hole GT3A) shows low sulfide‑sulfur concentrations (GT3A_median = 178 ppm, σ = 4873 ppm) but with great sulfur isotope variability (δ³⁴S = −12.8 to 14.4 ‰ V-CDT, weighted average + 5.8 ‰) and unusually heavy compositions relative to in-situ or ophiolitic crust. These features are consistent with abiogenic thermochemical sulfate reduction during intense hydrothermal alteration under greenschist facies conditions which formed a low-variance and …

The State Of Temperate Rainforest In South West England, Thomas Murphy, Katerina Chernyuk, Marcin Roszkowski, Shaun Lewin, Paul Lunt, James Buckley

School of Geography, Earth and Environmental Sciences

Temperate Rainforest is a biome of global significance which is rare and declining, yet supports endemic biodiversity and offers a range of co-benefits including carbon sequestration, natural flood management, climate moderation, and human well-being. The UK hosts a very large proportion of European bioclimatic space suitable for the development of Temperate Rainforest, yet very little of this woodland remains. In SW England, Temperate Rainforest habitat is mostly dominated by oak woodland (NVC communities W11 and W17) and occupies a broad but fragmented distribution across the region. SW temperate rainforest is exposed to a range of current and future threats and …

Arctic Fjord Ecosystem Adaptation To Cryosphere Meltdown Over The Past 14,000 Years, Jochen Knies, Youngkyu Ahn, Berenice Ebner, Lukas Smik, Kwangchul Jang, Seung Il Nam, Simon T. Belt, Carsten J. Schubert

School of Geography, Earth and Environmental Sciences

The Arctic cryosphere is the epicentre of acute global change impact, with abrupt warming and amplification driving rapid sea ice decline and irreversible glacial ice loss. A key challenge is understanding how the cryosphere meltdown will impact Arctic marine carbon cycles and ecosystems. Here, we use organic geochemical biomarkers to trace the contribution of different planktonic groups to organic carbon in Arctic fjord sediments (Kongsfjorden, Svalbard) during past warmer and colder (than present) climate states. We show that phytoplankton community structures changed abruptly with variable sea ice cover and glacial ice loss. Our results imply that future deglaciation of Svalbard …

Elevated Co2 Increases The Canopy Temperature Of Mature Quercus Robur (Pedunculate Oak), William Hagan Brown, Emanuel Gloor, Ralph Fyfe, A. Rob Mackenzie, Nicholas J. Harper, Peter Ganderton, Kris Hart, Giulio Curioni, Susan Quick, Scott J. Davidson, Emily Yetton, Jen L. Diehl, Sophie Fauset

School of Geography, Earth and Environmental Sciences

The canopy thermal response of natural forests to elevated CO₂ (eCO₂) is an understudied biophysical feedback in the global climate system. We investigated the effects of eCO₂ (150 μmol mol⁻¹ above ambient) on canopy temperature (T_can) dynamics of mature (> 175 years) Quercus robur (oak) at the Birmingham Institute for Forest Research Free Air CO₂ Enrichment (BIFoR-FACE) facility in Staffordshire, England, during the growing seasons of 2021, 2022 and 2023. We employed long-term, high-frequency thermal infrared (TIR) imaging to measure T_can. Our results show that daily maximum oak T_{can …}

Dyscluded': Women's Experiences Of Mothering Autistic Children As Described In Their Stories', Juliet Hall

School of Law, Humanities and Social Sciences Theses

My research, grounded in feminist research practices, uses an auto/biographical approach to explore the experiential knowledge of women mothering autistic children. It arose from a yearning for discovery. I use women’s stories to increase understanding of this experience to disrupt deeply embedded discourses and to benefit others with shared experiences.

There is a substantial body of knowledge on the experience of parent’s raising autistic children, however this tends to focus on a specific aspect of their autism journey. It is often presented in a gender-blind way. Much of it fails to acknowledge the implications of sociocultural expectations on mothers and …

Nurturing The Event: A Trauma-Informed Psychosocial Analysis Of Conversions To Christianity And Desistance From Crime, Alex Beaumont

School of Law, Humanities and Social Sciences Theses

The aim of this thesis is to demonstrate the role prison chaplaincy and faith-based organisations play in supporting new Christian converts across HMPPS establishments. Drawing on research data from 11 in-depth narrative interviews with formerly incarcerated individuals, many of whom were long-term desisters or still in the desistance process (18 months post-release), this thesis provides a psychoanalytic interpretation of the relationship between early childhood development, traumatic events, and spiritual transformations in prison. Data was gathered using Hollway and Jefferson’s (2001) Free Association Narrative Interview Method (FANIM), which applies psychoanalytic principles to explore subjectivity beyond surface-level descriptions of self and identity. …

An Investigation Of Maritime Piracy And Its Implications To The Development And Sustainability Of The Port Harcourt Seaport, Its Local Communities And The Niger Delta Region In Nigeria., Nsikan Umoette

Plymouth Business School Theses

ABSTRACTWithin the last decade, widespread ramifications of maritime piracy occasioned by insurmountable piratical attacks in the Gulf of Guinea region have been evidently seen in the Nigerian territorial waters with hallmarks on strategic areas in the Niger Delta region, Nigeria – the Port Harcourt seaport, its local communities, and the Niger Delta region. It is against this backdrop that this study investigates maritime piracy and its implications for the development and sustainability of the Port Harcourt Seaport, its local communities, and the Niger Delta region in Nigeria. Incorporating maritime piracy and sustainability in the literature review showed the social and …

The Potential For Diagnosing High Blood Pressure At The Dentist: An Examination Of Periodontal Disease And The Oral Microbiome In Raised Blood Pressure., Amazon Doble

Peninsula Dental School Theses

Background: Hypertension is increasingly linked to periodontitis. However, the nature and specific mechanistic relationship of this remains unclear, however may involve reduced oral and systemic nitric oxide (NO) availability. There remains limited research on the oral microbiome during hypertension that could support such a causative mechanism involving NO.Aims: This project aimed to examine links between periodontal disease, the oral microbiome, and raised blood pressure, while establishing a cardiovascular risk case-finding clinic with a GP referral pathway.Methods: The project comprised three studies: Study I established and identified cardiovascular risk case-finding in a dental environment (n=200). Study II evaluated clinical markers and …

From Recognition To Action: Surf-Driven Governance In The Manly And Freshwater World Surfing Reserve, Kizzy Beaumont, Joao Castro

School of Art, Design and Architecture

Executive summary This report presents findings from a focus group with members of the Manly and Freshwater World Surfing Reserve (WSR) Local Stewardship Council. Participants reflected on changes over the past decade and imagined future pathways for the WSR. Discussions revealed a strong sense of community pride and renewed momentum following the WSR’s relaunch, which has reconnected previously fragmented grassroots efforts.Key challenges identified included surf crowding, political inertia, water pollution, and a lack of formal governance mechanisms. While engagement with the local Council has improved, participants stressed the need for more consistent follow-through, youth inclusion, and funding security. Concerns were …

Palynology, Landscape And Land Use: Retrospect, Prospect And Research Agendas, Ralph Fyfe, Kevin Edwards, Laura Scoble

More Faculty of Science and Engineering Research

This paper provides a context for the use of anthropogenic palynology in the study of landscape and land use. Retrospective considerations indicate a history to current trends and inform future developments. Recent and prospective studies secure palynology as an essential element in archaeological and related environmental research. It is stressed that palynology is an inherently spatio-temporal discipline that can use concepts such as landscape or habitat heterogeneity as a future framework. This may be possible if recent advances in quantification of local vegetation cover, for example the use of model-based correction approaches within the Landscape Reconstruction Algorithm, are more widely …

Biomarkers In Coronary Artery Disease: Systematic Review And Meta-Analysis, Nicola King, Neil A. Smart, Theodore Bungon, Martin Peacock, Shakil A. Awan

Faculty of Science and Engineering Datasets

Little information exists regarding the detection of early coronary heart disease protein biomarkers. The aim of this study was to investigate several potential candidates. Systematic review was carried out followed by meta-analysis. The standardized mean difference (95% confidence intervals) for each comparison was: Troponins 2.31 (1.18, 3.4), iL-6 1.3 (0.8, 1.81), fibrinogen 1.55 (1.16, 1.94), NT-proBNP 1.05 (0.72, 1.38), lipoprotein a 0.75 (0.48, 1.03) osteoprotegerin 0.92 (0.23, 1.62), VCAM-1 1.53 (0.87, 2.18), pentraxin 3 0.87 (−0.13, 1.87), PAI-1 2.51 (−0.65, 5.66) MMP9 1.25 (0.36, 2.14), MCP-1 1.99 (1.12, 2.85) and adiponectin −1.11 (−1.49, −0.73). Multiple biomarkers that could potentially be …

Micro(Nano)Plastics In The Fish Gastrointestinal Tract: A Mini Review And Relevance To One Health Perspective, Farhan R. Khan, Nathaniel Clark, Elvis Genbo Xu

School of Biomedical Sciences

Micro(nano)plastics (MNPs) research in the piscine gastrointestinal tract has been a significant area of study. Understanding the environmental presence of microplastics, their potential for both localised and systemic effects, and their role as a gateway for MNPs and associated chemicals to enter the tissues and the food web, including the human food chain, is crucial. The fish gut, as a critical intersection between environmental, biotic, and human health, aligns with the One Health concept. We review the likely uptake mechanisms and toxicological damage caused by ingesting MNPs and their associated chemicals in fish, contextualised within the realms of digestive physiology …

Comparative Evaluation Of Swabbing Sites For Omicron Variant Detection In Pcr Testing, Tom Fowler, Edward Blandford, David Chapman, Matthias E Futschik, Raghavendran Kulasegaran-Shylini, Sarah Tunkel, Carolyn Lewis, Alasdair Fellows, Ellie Sheppard, Leanne Mccabe, Peter Marks, Paul E Klapper, Andrew Dodgson, Malur Sudhanva, Mike Kidd, Andy Vail, Susan Hopkins, Tim Peto

School of Biomedical Sciences

PURPOSE: The Omicron variant of SARS-CoV-2 raised concerns about the best sampling sites for PCR testing, with early indications suggesting throat swab samples were better than nasal swab samples. Our study evaluated the sensitivity of detecting SARS-CoV-2 across different swabbing sites.

METHODS: Participants undergoing testing at NHS Test and Trace sites in England provided self-collected samples using nose only, throat only, and combined nose and throat swabs, which were analysed by realtime PCR.

RESULTS: Among 815 participants, combined swabs had higher viral concentrations than nose only or throat only swabs. Sensitivity for detecting SARS-CoV-2 by PCR was 91 % for …

Singapore’S Health Outcomes After Critical Illness In Kids: A Mixed-Methods Longitudinal Cohort Study To Explore Health Outcomes Of Children And Parents Six Months After Critical Illness, Pei Fen Poh

School of Nursing and Midwifery Theses

Background: Post-Intensive Care Syndrome in paediatrics (PICS-p) encompasses physical, cognitive, social, and emotional health impairments in children, as well as psychological challenges in parents, following PICU discharge. While PICS is well-studied in adults, research on its long-term effects in the paediatric population is limited, and the influence of ethnicity remains unexplored.Aim: The aim of this study was to explore and understand the long-term health outcomes and experiences of children and their parents during the first six months following discharge from the paediatric intensive care unit (PICU), and to examine the influence of ethnicity. Methods: The SHACK study was informed by …

Lipid Biomarkers For Marine Fungi, Emily Cooper

School of Geography, Earth and Environmental Sciences Theses

Marine fungi play key roles as parasites and saprotrophs in marine ecosystems and are important degraders of organic matter. They likely facilitate the remineralisation of marine carbon, thus have a profound impact on marine biogeochemical cycles. However, as little is known about their global abundance and biomass, fungi are yet to be included in biogeochemical models. Lipid biomarkers can be used to assess microbial abundance and biomass due to their specificity and may be utilised to explore the viability and trophic dynamics of marine microbial communities. Although lipid biomarkers for fungi have been used in terrestrial environments, such as soils, …

Links Between Adhesion Signalling And Cell Cycle Regulation In Bladder Cancer Cells, Michael Jones

Peninsula Medical School Theses

Bladder cancer is the most common malignancy of the urinary tract. However, bladder cancer is a highly heterogenous disease and our understanding of the mechanisms that drive disease progression remain ill-defined. Additionally, a limited range of therapeutics and the dismal prognosis of patients with advanced disease highlights a need for better understanding of the mechanisms that drive bladder cancer progression, in order to identify new avenues for therapy. The extracellular matrix (ECM) represents a key component of the tumour microenvironment whose biochemical and mechanical characteristics contribute to all the hallmarks of cancer. However, the role of the ECM in bladder …

Differential Expression Of Proteins Involved In Sev Biogenesis And Secretion In Parkinson’S Disease And Dementia With Lewy Bodies, Anis Sahoo

Peninsula Medical School Theses

Exosomes, small extracellular vesicles (sEVs), play a pivotal role in cell-to-cell communication, carrying diverse biomolecules such as proteins, lipids, and nucleic acids. Their ability to transport these molecules makes them fundamental to various physiological processes and valuable in diagnosing and treating disorders of the central nervous system (CNS). To fully utilise sEVs potential, more attention is needed to understand not only the cargo, but also proteins and pathways involved in the biogenesis of EVs, particularly in the context of diseases. This thesis explores changes in sEV-associated proteins in synucleinopathies, notably Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).Aims1. In …

The Discovery Of P62-Dependent Processing Bodies, Elizabeth Barrow

Peninsula Medical School Theses

The cellular degradation process autophagy can be a selective process during which, cellular components, such as excess proteins, can be marked for degradation by the post translational modification ubiquitination. Proteins that act as selective autophagy receptors can recognise the ubiquitinated substrates and target them to the selective autophagy pathway, facilitating their degradation and thereby mediating cellular homeostasis. The selective autophagy receptor Sequestome 1 (p62) undergoes liquid-liquid phase separation (LLPS) to form p62 bodies to mediate the autophagic degradation of ubiquitinated proteins. At the time of this research, it was unknown whether p62 could exist in a differential droplet form to …

Exploring The Immune Landscape Of The Tumour Microenvironment In Meningiomas And The Role Of Immune Infiltration In Meningioma Models, Ting Zhang

Peninsula Medical School Theses

Background: Meningiomas are the most common primary intracranial tumours, ranging from benign to highly aggressive forms. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic approaches. Immunotherapy shows promise, however, the role of tumour microenvironment (TME), particularly tumour-associated macrophages (TAMs), in meningiomas remains poorly understood, especially concerning genomic alterations. Aims: To investigate the immune landscape of meningiomas classified by grades, genotypes and methylation classes (MCs), and to elucidate the role of the TAMs in meningioma progression utilising a patient-derived 3D co-culture model.Methods: …

Targeting Aldehyde Dehydrogenases In Nf2-Null Meningioma And Schwannoma, Libby Williams

Peninsula Medical School Theses

Meningioma and schwannoma are tumours of the brain and nervous system that are frequently driven by loss or mutation of the gene NF2, which encodes the tumour suppressor protein Merlin. Dysregulated Hippo pathway signalling, caused by NF2 loss, drives overexpression of aldehyde dehydrogenase 1A1 (ALDH1A1) in NF2-null schwannoma. High expression of ALDH1A1, and the related isoform ALDH1A3 have been identified as markers of cancer stem cell activity and have been correlated with poor prognosis and chemoresistance in several cancers. This project aims to clarify the role ofaldehyde dehydrogenase (ALDH) enzymes in meningioma tumours and evaluate their potential as future therapeutic …