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Is Patient Acceptance Of The Diagnosis Of Psychogenic Nonepileptic Seizures Linked To Symptomatology?, Mark Thaller, Michael E. Hyland, Rohan Kandasamy, Martin Sadler Mar 2016

Is Patient Acceptance Of The Diagnosis Of Psychogenic Nonepileptic Seizures Linked To Symptomatology?, Mark Thaller, Michael E. Hyland, Rohan Kandasamy, Martin Sadler

School of Psychology

No abstract provided.


Shaping The Role Of 'Fast' And 'Slow' Drivers Of Change In Forest-Shrubland Socio-Ecological Systems, Agostino Ferrara, Claire Kelly, Geoff A. Wilson, Angelo Nolè, Giuseppe Mancino, Sofia Bajocco, Luca Salvati Mar 2016

Shaping The Role Of 'Fast' And 'Slow' Drivers Of Change In Forest-Shrubland Socio-Ecological Systems, Agostino Ferrara, Claire Kelly, Geoff A. Wilson, Angelo Nolè, Giuseppe Mancino, Sofia Bajocco, Luca Salvati

School of Geography, Earth and Environmental Sciences

The temporal speeds and spatial scales at which ecosystem processes operate are often at odds with the scale and speed at which natural resources such as soil, water and vegetation are managed those. Scale mismatches often occur as a result of the time-lag between policy development, implementation and observable changes in natural capital in particular. In this study, we analyse some of the transformations that can occur in complex forest-shrubland socio-ecological systems undergoing biophysical and socioeconomic change. We use a Multiway Factor Analysis (MFA) applied to a representative set of variables to assess changes in components of natural, economic and …


A Hybrid Computer Case Study For Unconventional Virtual Computing, A Kirke, P Shadbolt, A Neville, E Miranda Mar 2016

A Hybrid Computer Case Study For Unconventional Virtual Computing, A Kirke, P Shadbolt, A Neville, E Miranda

School of Art, Design and Architecture

Improvements in computer efficiency are not always due to increasing computation speed. The mouse and GUI approach to OS’s actually slowed down computation, but sped up computing. This paper highlights the concept of Unconventional Virtual Computation (UVC). With the increasing virtualization of computers, and the recognition that this year’s virtual computers are as fast as the hardware computers of 10 years ago, it becomes clear that we are only limited in our modes of computation by our imagination. A form of UVC is presented called Pulsed Melodic Affective Processing, which utilizes melodies to perform affective computations. PMAP makes computation more …


Marine Ecosystem Services Of St. Helena Part 2: Ecosystem Service Valuations, Future Development Thresholds And Management, Se Rees Mar 2016

Marine Ecosystem Services Of St. Helena Part 2: Ecosystem Service Valuations, Future Development Thresholds And Management, Se Rees

School of Biological and Marine Sciences

No abstract provided.


The Need For Speed In A Crisis Discipline: Perspectives On Peer-Review Duration And Implications For Conservation Science, Steven J. Cooke, Vivian M. Nguyen, Alexander D.M. Wilson, Michael R. Donaldson, Austin J. Gallagher, Neil Hammerschlag, Neal R. Haddaway Mar 2016

The Need For Speed In A Crisis Discipline: Perspectives On Peer-Review Duration And Implications For Conservation Science, Steven J. Cooke, Vivian M. Nguyen, Alexander D.M. Wilson, Michael R. Donaldson, Austin J. Gallagher, Neil Hammerschlag, Neal R. Haddaway

School of Biological and Marine Sciences

No abstract provided.


Noradrenaline Effects On Social Behaviour, Intergroup Relations, And Moral Decisions, S Terbeck, J Savulescu, P Cowen Mar 2016

Noradrenaline Effects On Social Behaviour, Intergroup Relations, And Moral Decisions, S Terbeck, J Savulescu, P Cowen

School of Psychology

Recent research has begun to elucidate the neural basis of higher order social concepts, such as the mechanisms involved in intergroup relations, and moral judgments. Most theories have concentrated on higher order emotions, such as guilt, shame, or empathy, as core mechanisms. Accordingly, psychopharmacological and neurobiological studies have investigated the effects of manipulating serotonin or oxytocin activity on moral and social decisions and attitudes. However, recently it has been determined that changes in more basic emotions, such as fear and anger, might also have a significant role in social and moral cognition. This article summarizes psychopharmacological and fMRI research on …


International Perspectives On The State-As-Parent: Naı¨Ve Idealism Or Reluctant Pragmatism, Pa Welbourne, J Dixon Mar 2016

International Perspectives On The State-As-Parent: Naı¨Ve Idealism Or Reluctant Pragmatism, Pa Welbourne, J Dixon

School of Health Professions

Too many children remain at risk of harm, regrettably, in all too many societies. This is despite the almost universal acceptance of the 1990 United Nations Convention on the Rights of the Child (UNCRC). Its intention, arguably somewhat naı¨vely, is to create two state imperatives: to protect children against threats of harm; and to advance their welfare. Governments, however, have evidenced a pragmatic reluctance to meet these challenges, perhaps a product of conflicting community expectations on the appropriate role of the state, combined with a scarcity of public resources. For the state to meet its UNCRC obligations requires it to …


Supplementation Of Formulated Diets For Tilapia (Oreochromis Niloticus) With Selected Exogenous Enzymes: Overall Performance And Effects On Intestinal Histology And Microbiota, A. A. Adeoye, A. Jaramillo-Torres, S. W. Fox, D. L. Merrifield, S. J. Davies Mar 2016

Supplementation Of Formulated Diets For Tilapia (Oreochromis Niloticus) With Selected Exogenous Enzymes: Overall Performance And Effects On Intestinal Histology And Microbiota, A. A. Adeoye, A. Jaramillo-Torres, S. W. Fox, D. L. Merrifield, S. J. Davies

School of Biomedical Sciences

Abstract This study was conducted to evaluate the effects of exogenous enzymes on Nile tilapia (Oreochromis niloticus) growth and general health status. Tilapia (38.7 g) were fed one of four plant-based diets (408 g kg−1protein, 78 g kg−1 lipid); one of which was a control and the remaining three were supplemented with exogenous enzymes (phytase, protease and carbohydrase at 300 mg kg−1, 200 mg kg−1, and 300 mg kg−1, respectively). Tilapia fed the phytase supplemented diet displayed higher final body weight, FBW (94.9 g fish−1) and specific growth rate, SGR (2.48% day−1) compared to tilapia fed the control diet (82.6 …


Use And Perception Of Collars For Companion Cats In New Zealand, M Harrod, Aj Keown, Mj Farnworth Mar 2016

Use And Perception Of Collars For Companion Cats In New Zealand, M Harrod, Aj Keown, Mj Farnworth

School of Biological and Marine Sciences

AIMS: To investigate the use and utility of collars for companion cats in New Zealand, and to explore public perception of collar use. METHODS: An online questionnaire was distributed using emails and social media to members of the general public in New Zealand. The questionnaire collected details of respondents, cat ownership status, and responses to a number of questions regarding collar use in cats. RESULTS: A total of 511 responses were collected. Of these, 393/511 (76.9%) reported owning ≥1 cat at the time of the survey, and 141/393 (35.9%) stated that ≥1 of their cats wore collars and 211/393 (53.7%) …


Marine Ecosystem Services Assessment Of St. Helena, Se Rees Mar 2016

Marine Ecosystem Services Assessment Of St. Helena, Se Rees

School of Biological and Marine Sciences

No abstract provided.


Expected Effects Of Offshore Wind Farms On Mediterranean Marine Life, Laura Bray, Sofia Reizopoulou, Evangelos Voukouvalas, Takvor Soukissian, Carme Alomar, M Vazquez-Luis, Salud Deudero, Martin J. Attrill, Jason M. Hall-Spencer Mar 2016

Expected Effects Of Offshore Wind Farms On Mediterranean Marine Life, Laura Bray, Sofia Reizopoulou, Evangelos Voukouvalas, Takvor Soukissian, Carme Alomar, M Vazquez-Luis, Salud Deudero, Martin J. Attrill, Jason M. Hall-Spencer

School of Biological and Marine Sciences

Current climate policy and issues of energy security mean wind farms are being built at an increasing rate to meet energy demand. As wind farm development is very likely in the Mediterranean Sea, we provide an assessment of the offshore wind potential and identify expected biological effects of such developments in the region. We break new ground here by identifying potential offshore wind farm (OWF) “hotspots” in the Mediterranean. Using lessons learned in Northern Europe, and small-scale experiments in the Mediterranean, we identify sensitive species and habitats that will likely be influenced by OWFs in both these hotspot areas and …


The Unfolded Protein Response And Its Potential Role In Huntington's Disease Elucidated By A Systems Biology Approach, Rkr Kalathur, J Giner-Lamia, S Machado, T Barata, Krs Ayasolla, Me Futschik Mar 2016

The Unfolded Protein Response And Its Potential Role In Huntington's Disease Elucidated By A Systems Biology Approach, Rkr Kalathur, J Giner-Lamia, S Machado, T Barata, Krs Ayasolla, Me Futschik

School of Biomedical Sciences

Huntington ́s disease (HD) is a progressive, neurodegenerative disease with a fatal outcome. Although the disease-causing gene (huntingtin) has been known for over 20 years, the exact mechanisms leading to neuronal cell death are still controversial. One potential mechanism contributing to the massive loss of neurons observed in the brain of HD patients could be the unfolded protein response (UPR) activated by accumulation of misfolded proteins in the endoplasmic reticulum (ER). As an adaptive response to counter-balance accumulation of un- or misfolded proteins, the UPR upregulates transcription of chaperones, temporarily attenuates new translation, and activates protein degradation via the proteasome. …


Temporal Fluctuations In Seawater Pco2 May Be As Important As Mean Differences When Determining Physiological Sensitivity In Natural Systems, Daniel P. Small, Marco Milazzo, Camilla Bertolini, Helen Graham, Chris Hauton, Jason M. Hall-Spencer, Samuel P.S. Rastrick Mar 2016

Temporal Fluctuations In Seawater Pco2 May Be As Important As Mean Differences When Determining Physiological Sensitivity In Natural Systems, Daniel P. Small, Marco Milazzo, Camilla Bertolini, Helen Graham, Chris Hauton, Jason M. Hall-Spencer, Samuel P.S. Rastrick

School of Biological and Marine Sciences

AbstractMost studies assessing the impacts of ocean acidification (OA) on benthic marine invertebrates have used stable mean pH/pCO2 levels to highlight variation in the physiological sensitivities in a range of taxa. However, many marine environments experience natural fluctuations in carbonate chemistry, and to date little attempt has been made to understand the effect of naturally fluctuating seawater pCO2 (pCO2sw) on the physiological capacity of organisms to maintain acid–base homeostasis. Here, for the first time, we exposed two species of sea urchin with different acid–base tolerances, Paracentrotus lividus and Arbacia lixula, to naturally fluctuating pCO2sw conditions at shallow water CO2 seep …


The Impact Of Ocean Acidification And Warming On The Skeletal Mechanical Properties Of The Sea Urchin Paracentrotus Lividus From Laboratory And Field Observations, Marie Collard, Samuel P.S. Rastrick, Piero Calosi, Yoann Demolder, Jean Dille, Helen S. Findlay, Jason Michael Hall-Spencer, Marco Milazzo, Laure Moulin, Steve Widdicombe, Frank Dehairs, Philippe Dubois Mar 2016

The Impact Of Ocean Acidification And Warming On The Skeletal Mechanical Properties Of The Sea Urchin Paracentrotus Lividus From Laboratory And Field Observations, Marie Collard, Samuel P.S. Rastrick, Piero Calosi, Yoann Demolder, Jean Dille, Helen S. Findlay, Jason Michael Hall-Spencer, Marco Milazzo, Laure Moulin, Steve Widdicombe, Frank Dehairs, Philippe Dubois

School of Biological and Marine Sciences

AbstractIncreased atmospheric CO2 concentration is leading to changes in the carbonate chemistry and the temperature of the ocean. The impact of these processes on marine organisms will depend on their ability to cope with those changes, particularly the maintenance of calcium carbonate structures. Both a laboratory experiment (long-term exposure to decreased pH and increased temperature) and collections of individuals from natural environments characterized by low pH levels (individuals from intertidal pools and around a CO2 seep) were here coupled to comprehensively study the impact of near-future conditions of pH and temperature on the mechanical properties of the skeleton of the …


Wap Four-Disulfide Core Domain Protein 2 Gene(Wfdc2) Is A Target Of Estrogen In Ovarian Cancer Cells, Y Chen, S Wang, T Liu, Et Al Feb 2016

Wap Four-Disulfide Core Domain Protein 2 Gene(Wfdc2) Is A Target Of Estrogen In Ovarian Cancer Cells, Y Chen, S Wang, T Liu, Et Al

Peninsula Medical School

BACKGROUND: WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. METHODS: We investigated the role of estradiol (E2) on cell growth in estrogen-sensitive or estrogen-insensitive ovarian cancer cell lines. Real-time (RT)-PCR and western blotting were used to examine the expression of WFDC2 at RNA and protein levels. Growth traits of cells transfected with WFDC2-shRNA or blank control were assessed using MMT arrays. Cell apoptosis was analyzed using annexin V-FITC/PI and flow cytometry. Estrogen receptor expression was evaluated using RT-PCR and flow cytometry. Apoptosis-related proteins induced by E2 directly and indirectly were determined …


The Transcriptional Landscape Of The Photosynthetic Model Cyanobacterium Synechocystis Sp. Pcc6803, Miguel A. Hernández-Prieto, Trudi Ann Semeniuk, Joaquín Giner-Lamia, Matthias E. Futschik Feb 2016

The Transcriptional Landscape Of The Photosynthetic Model Cyanobacterium Synechocystis Sp. Pcc6803, Miguel A. Hernández-Prieto, Trudi Ann Semeniuk, Joaquín Giner-Lamia, Matthias E. Futschik

School of Biomedical Sciences

AbstractCyanobacteria exhibit a great capacity to adapt to different environmental conditions through changes in gene expression. Although this plasticity has been extensively studied in the model cyanobacterium Synechocystis sp. PCC 6803, a detailed analysis of the coordinated transcriptional adaption across varying conditions is lacking. Here, we report a meta-analysis of 756 individual microarray measurements conducted in 37 independent studies-the most comprehensive study of the Synechocystis transcriptome to date. Using stringent statistical evaluation, we characterized the coordinated adaptation of Synechocystis’ gene expression on systems level. Evaluation of the data revealed that the photosynthetic apparatus is subjected to greater changes in expression …


The Role Of Biophysical Cohesion On Subaqueous Bed Form Size, Daniel R. Parsons, Robert J. Schindler, Julie A. Hope, Jonathan Malarkey, Jaco H. Baas, Jeffrey Peakall, Andrew J. Manning, Leiping Ye, Steve Simmons, David M. Paterson, Rebecca J. Aspden, Sarah J. Bass, Alan G. Davies, Ian D. Lichtman, Peter D. Thorne Feb 2016

The Role Of Biophysical Cohesion On Subaqueous Bed Form Size, Daniel R. Parsons, Robert J. Schindler, Julie A. Hope, Jonathan Malarkey, Jaco H. Baas, Jeffrey Peakall, Andrew J. Manning, Leiping Ye, Steve Simmons, David M. Paterson, Rebecca J. Aspden, Sarah J. Bass, Alan G. Davies, Ian D. Lichtman, Peter D. Thorne

School of Geography, Earth and Environmental Sciences

AbstractBiologically active, fine‐grained sediment forms abundant sedimentary deposits on Earth's surface, and mixed mud‐sand dominates many coasts, deltas, and estuaries. Our predictions of sediment transport and bed roughness in these environments presently rely on empirically based bed form predictors that are based exclusively on biologically inactive cohesionless silt, sand, and gravel. This approach underpins many paleoenvironmental reconstructions of sedimentary successions, which rely on analysis of cross‐stratification and bounding surfaces produced by migrating bed forms. Here we present controlled laboratory experiments that identify and quantify the influence of physical and biological cohesion on equilibrium bed form morphology. The results show the …


Fatty Acid Activated Pparγ Promotes Tumorigenicity Of Prostate Cancer Cells By Up Regulating Vegf Via Ppar Responsive Elements Of The Promoter, Fs Forootan, Ss Forootan, X Gou, J Yang, Et Al Feb 2016

Fatty Acid Activated Pparγ Promotes Tumorigenicity Of Prostate Cancer Cells By Up Regulating Vegf Via Ppar Responsive Elements Of The Promoter, Fs Forootan, Ss Forootan, X Gou, J Yang, Et Al

Peninsula Medical School

In previous work, it is suggested that the excessive amount of fatty acids transported by FABP5 may facilitate the malignant progression of prostate cancer cells through a FABP5-PPARγ-VEGF signal transduction axis to increase angiogenesis. To further functionally characterise the FABP5-PPARγ-VEGF signal transduction pathway, we have, in this work, investigated the molecular mechanisms involved in its tumorigenicity promoting role in prostate cancer. Suppression of PPARγ in highly malignant prostate cancer cells produced a significant reduction (up to 53%) in their proliferation rate, invasiveness (up to 89%) and anchorage-independent growth (up to 94%) in vitro. Knockdown of PPARγ gene in PC3-M cells …


Time-Coded Neurotransmitter Release At Excitatory And Inhibitory Synapses, S Rodrigues, M Desroches, M Krupa, Et Al Feb 2016

Time-Coded Neurotransmitter Release At Excitatory And Inhibitory Synapses, S Rodrigues, M Desroches, M Krupa, Et Al

School of Engineering, Computing and Mathematics

Neurotransmitter exocytosis and short-term synaptic plasticity (STSP) regulate large-scale brain electrical activity. This study is the first, to our knowledge, proposing a multiple-time-scale model that bridges between the microscopic and mesoscopic scales. It is parsimonious, yet with enough descriptive power to express, on the one hand, the interactions between the SNARE and Sec1/Munc18 (SM) protein complexes mediating all forms of neurotransmitter release and STSP and, on the other hand, the electrical activity required for neuronal communication. A key finding is the discovery of a mathematical structure, termed activity-induced transcritical canard, which quantifies and explains delayed and irregular exocytosis. This structure …


Direct Measurements Of Oxygen Gradients In Spheroid Culture System Using Electron Parametric Resonance Oximetry, Laura M. Langan, Nicholas J.F. Dodd, Stewart F. Owen, Wendy M. Purcell, Simon K. Jackson, Awadhesh N. Jha Feb 2016

Direct Measurements Of Oxygen Gradients In Spheroid Culture System Using Electron Parametric Resonance Oximetry, Laura M. Langan, Nicholas J.F. Dodd, Stewart F. Owen, Wendy M. Purcell, Simon K. Jackson, Awadhesh N. Jha

School of Biomedical Sciences

No abstract provided.


Proteome Based Construction Of The Lymphocyte Function-Associated Antigen 1 (Lfa-1) Interactome In Human Dendritic Cells, C Eich, E Lasonder, Lj Cruz, I Reinieren-Beeren, Et Al Feb 2016

Proteome Based Construction Of The Lymphocyte Function-Associated Antigen 1 (Lfa-1) Interactome In Human Dendritic Cells, C Eich, E Lasonder, Lj Cruz, I Reinieren-Beeren, Et Al

School of Biomedical Sciences

The β2-integrin lymphocyte function-associated antigen 1 (LFA-1) plays an important role in the migration, adhesion and intercellular communication of dendritic cells (DCs). During the differentiation of human DCs from monocyte precursors, LFA-1 ligand binding capacity is completely lost, even though its expression levels were remained constant. Yet LFA-1-mediated adhesive capacity on DCs can be regained by exposing DCs to the chemokine CCL21, suggesting a high degree of regulation of LFA-1 activity during the course of DC differentiation. The molecular mechanisms underlying this regulation of LFA-1 function in DCs, however, remain elusive. To get more insight we attempted to identify specific …


Transport Conductivity Of Graphene At Rf And Microwave Frequencies, S. A. Awan, A. Lombardo, A. Colli, G. Privitera, T. S. Kulmala, J. M. Kivioja, M. Koshino, A. C. Ferrari Feb 2016

Transport Conductivity Of Graphene At Rf And Microwave Frequencies, S. A. Awan, A. Lombardo, A. Colli, G. Privitera, T. S. Kulmala, J. M. Kivioja, M. Koshino, A. C. Ferrari

School of Engineering, Computing and Mathematics

No abstract provided.


Dual Transcriptional-Translational Cascade Permits Cellular Level Tuneable Expression Control, Rosa Morra, Jayendra Shankar, Christopher J. Robinson, Samantha Halliwell, Lisa Butler, Mathew Upton, Sam Hay, Jason Micklefield, Neil Dixon Feb 2016

Dual Transcriptional-Translational Cascade Permits Cellular Level Tuneable Expression Control, Rosa Morra, Jayendra Shankar, Christopher J. Robinson, Samantha Halliwell, Lisa Butler, Mathew Upton, Sam Hay, Jason Micklefield, Neil Dixon

School of Biomedical Sciences

No abstract provided.


Direct Measurement Of Hairpin‐Like Vortices In The Bottom Boundary Layer Of The Coastal Ocean, Edward C.C. Steele, W. Alex M. Nimmo‐Smith, Andrey Vlasenko Feb 2016

Direct Measurement Of Hairpin‐Like Vortices In The Bottom Boundary Layer Of The Coastal Ocean, Edward C.C. Steele, W. Alex M. Nimmo‐Smith, Andrey Vlasenko

School of Biological and Marine Sciences

Laboratory measurements and numerical modeling at low Reynolds numbers (Reθ<7700) indicate the energy-containing turbulence of boundary layer flows comprises coherent packets of hairpin vortices. Here direct measurements in the bottom boundary layer of the coastal ocean at higher Reynolds numbers (Reθ = 266,150) show tidal flows also contain packets of large vortices separated by periods of more quiescent conditions. The 1452 vortices recorded within a 20 min period are typically aligned along stream (∼8.0° from the mean flow direction) and inclined to the horizontal (∼27.0° from the seabed), with a mean period of occurrence of 4.3 s. These results lend three-dimensional, in situ support to an interpretation of the coastal ocean bottom boundary layer as comprising coherent packets of hairpin vortices. This demonstrates a direct linkage from low Reynolds …


Cytomegalovirus-Based Vaccine Expressing Ebola Virus Glycoprotein Protects Nonhuman Primates From Ebola Virus Infection, Andrea Marzi, Aisling A. Murphy, F Feldmann, Christopher J. Parkins, Elaine Haddock, Patrick W. Hanley, Matthew J. Emery, Flora Engelmann, Ilhem Messaoudi, H Feldmann, Michael A. Jarvis Feb 2016

Cytomegalovirus-Based Vaccine Expressing Ebola Virus Glycoprotein Protects Nonhuman Primates From Ebola Virus Infection, Andrea Marzi, Aisling A. Murphy, F Feldmann, Christopher J. Parkins, Elaine Haddock, Patrick W. Hanley, Matthew J. Emery, Flora Engelmann, Ilhem Messaoudi, H Feldmann, Michael A. Jarvis

School of Biomedical Sciences

AbstractEbolaviruses pose significant public health problems due to their high lethality, unpredictable emergence, and localization to the poorest areas of the world. In addition to implementation of standard public health control procedures, a number of experimental human vaccines are being explored as a further means for outbreak control. Recombinant cytomegalovirus (CMV)-based vectors are a novel vaccine platform that have been shown to induce substantial levels of durable, but primarily T-cell-biased responses against the encoded heterologous target antigen. Herein, we demonstrate the ability of rhesus CMV (RhCMV) expressing Ebola virus (EBOV) glycoprotein (GP) to provide protective immunity to rhesus macaques against …


No Effect Of Acute Beetroot Juice Ingestion On Oxygen Consumption, Glucose Kinetics, Or Skeletal Muscle Metabolism During Submaximal Exercise In Males, Scott Betteridge, Raúl Bescós, Miquel Martorell, Antoni Pons, Andrew P. Garnham, Christos C. Stathis, Glenn K. Mcconell Feb 2016

No Effect Of Acute Beetroot Juice Ingestion On Oxygen Consumption, Glucose Kinetics, Or Skeletal Muscle Metabolism During Submaximal Exercise In Males, Scott Betteridge, Raúl Bescós, Miquel Martorell, Antoni Pons, Andrew P. Garnham, Christos C. Stathis, Glenn K. Mcconell

School of Health Professions

Beetroot juice, which is rich in nitrate (NO3−), has been shown in some studies to decrease oxygen consumption (V̇o2) for a given exercise workload, i.e., increasing efficiency and exercise tolerance. Few studies have examined the effect of beetroot juice or nitrate supplementation on exercise metabolism. Eight healthy recreationally active males participated in three trials involving ingestion of either beetroot juice (Beet; ∼8 mmol NO3−), Placebo (nitrate-depleted Beet), or Beet + mouthwash (Beet+MW), all of which were performed in a randomized single-blind crossover design. Two-and-a-half hours later, participants cycled for 60 min on an ergometer at 65% of V̇o2 peak. [6,6-2H]glucose …


An Evaluation Of Extraction Techniques For Arsenic In Staple Diets (Fish And Rice) Utilising Both Classical And Enzymatic Extraction Methods, Bashdar A. Sadee, Mike E. Foulkes, Steve J. Hill Feb 2016

An Evaluation Of Extraction Techniques For Arsenic In Staple Diets (Fish And Rice) Utilising Both Classical And Enzymatic Extraction Methods, Bashdar A. Sadee, Mike E. Foulkes, Steve J. Hill

School of Geography, Earth and Environmental Sciences

Enzymatic extraction methods were evaluated with classical extraction approaches for the determination of arsenic in food. The extraction efficiency for total arsenic was determined by analysing CRM materials DORM-3 fish protein, NIES 106 rice flour and GBW10015 spinach. These were compared with total arsenic concentration determined using microwave-assisted acid digestion and ICP-MS. The total arsenic concentrations in the CRM materials were in good agreement with the certified values. Enzymatic hydrolysis using trypsin has been successfully employed to extract arsenic species in DORM-3 and fish samples. Whilst this method of hydrolysing the proteins worked well for the fish samples, an alternative …


Exploring Food Experiences And Challenges In Traditionally Hard-To-Reach Adults Through A Cross-Sectional Questionnaire., R Burnett, C Hallam, R Kirby, H Ponting, N White, C Pettinger Feb 2016

Exploring Food Experiences And Challenges In Traditionally Hard-To-Reach Adults Through A Cross-Sectional Questionnaire., R Burnett, C Hallam, R Kirby, H Ponting, N White, C Pettinger

School of Health Professions

No abstract provided.


High Proportion Of Smaller Ranged Hummingbird Species Coincides With Ecological Specialization Across The Americas, Jesper Sonne, Ana M. Martín González, Pietro K. Maruyama, Brody Sandel, Jeferson Vizentin-Bugoni, Matthias Schleuning, Stefan Abrahamczyk, Ruben Alarcón, Andréa C. Araujo, Francielle P. Araújo, Severino Mendes De Azevedo, Andrea C. Baquero, Peter A. Cotton, Tanja Toftemark Ingversen, Glauco Kohler, Carlos Lara, Flor Maria Guedes Las-Casas, Adriana O. Machado, Caio Graco Machado, María Alejandra Maglianesi, Alan Cerqueira Moura, David Nogués-Bravo, Genilda M. Oliveira, Paulo E. Oliveira, Juan Francisco Ornelas, Licléia Da Cruz Rodrigues, Liliana Rosero-Lasprilla, Ana Maria Rui, Marlies Sazima, Allan Timmermann, Ig Varassin, Z Wang, S Watts, J Fjeldså, J-C Svenning, C Rahbek, B Dalsgaard Feb 2016

High Proportion Of Smaller Ranged Hummingbird Species Coincides With Ecological Specialization Across The Americas, Jesper Sonne, Ana M. Martín González, Pietro K. Maruyama, Brody Sandel, Jeferson Vizentin-Bugoni, Matthias Schleuning, Stefan Abrahamczyk, Ruben Alarcón, Andréa C. Araujo, Francielle P. Araújo, Severino Mendes De Azevedo, Andrea C. Baquero, Peter A. Cotton, Tanja Toftemark Ingversen, Glauco Kohler, Carlos Lara, Flor Maria Guedes Las-Casas, Adriana O. Machado, Caio Graco Machado, María Alejandra Maglianesi, Alan Cerqueira Moura, David Nogués-Bravo, Genilda M. Oliveira, Paulo E. Oliveira, Juan Francisco Ornelas, Licléia Da Cruz Rodrigues, Liliana Rosero-Lasprilla, Ana Maria Rui, Marlies Sazima, Allan Timmermann, Ig Varassin, Z Wang, S Watts, J Fjeldså, J-C Svenning, C Rahbek, B Dalsgaard

School of Biological and Marine Sciences

Ecological communities that experience stable climate conditions have been speculated to preserve more specialized interspecific associations and have higher proportions of smaller ranged species (SRS). Thus, areas with disproportionally large numbers of SRS are expected to coincide geographically with a high degree of community-level ecological specialization, but this suggestion remains poorly supported with empirical evidence. Here, we analysed data for hummingbird resource specialization, range size, contemporary climate, and Late Quaternary climate stability for 46 hummingbird–plant mutualistic networks distributed across the Americas, representing 130 hummingbird species (ca 40% of all hummingbird species). We demonstrate a positive relationship between the proportion of …


Promoting The 3rs To Enhance The Oecd Fish Toxicity Testing Framework., Th Hutchinson, Jr Wheeler, A Gourmelon, N Burden Feb 2016

Promoting The 3rs To Enhance The Oecd Fish Toxicity Testing Framework., Th Hutchinson, Jr Wheeler, A Gourmelon, N Burden

School of Geography, Earth and Environmental Sciences

Fish toxicity testing has been conducted since the 1860's in order to help define safe levels of chemical contaminants in lakes, rivers and coastal waters. The historical emphasis on acute lethality testing of chemicals has more recently focussed on long term sublethal effects of chemicals on fish and their prey species. Fish toxicity testing is now embedded in much environment legislation on chemical safety while it is recognized that animal use should be Replaced, Reduced and Refined (the 3Rs) where possible. The OECD Fish Toxicity Testing Framework provides a useful structure with which to address the needs of environmental safety …