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Articles 2221 - 2250 of 6794
Full-Text Articles in Entire DC Network
Prioritizing Progressive Ms Rehabilitation Research: A Call From The International Progressive Ms Alliance, Kathleen M. Zackowski, Jennifer Freeman, Giampaolo Brichetto, Diego Centonze, Ulrik Dalgas, John Deluca, Dawn Ehde, Sara Elgott, Vanessa Fanning, Peter Feys, Marcia Finlayson, Stefan M. Gold, Matilde Inglese, Ruth Ann Marrie, Michelle Ploughman, Christine N. Sang, Jaume Sastre-Garriga, Caroline Sincock, Jonathan Strum, Beek J Van, Anthony Feinstein
Prioritizing Progressive Ms Rehabilitation Research: A Call From The International Progressive Ms Alliance, Kathleen M. Zackowski, Jennifer Freeman, Giampaolo Brichetto, Diego Centonze, Ulrik Dalgas, John Deluca, Dawn Ehde, Sara Elgott, Vanessa Fanning, Peter Feys, Marcia Finlayson, Stefan M. Gold, Matilde Inglese, Ruth Ann Marrie, Michelle Ploughman, Christine N. Sang, Jaume Sastre-Garriga, Caroline Sincock, Jonathan Strum, Beek J Van, Anthony Feinstein
School of Health Professions
Background: People with multiple sclerosis (MS) experience myriad symptoms that negatively affect their quality of life. Despite significant progress in rehabilitation strategies for people living with relapsing-remitting MS (RRMS), the development of similar strategies for people with progressive MS has received little attention. Objective: To highlight key symptoms of importance to people with progressive MS and stimulate the design and implementation of high-quality studies focused on symptom management and rehabilitation. Methods: A group of international research experts, representatives from industry, and people affected by progressive MS was convened by the International Progressive MS Alliance to devise research priorities for addressing …
Author Correction: High-Resolution, Large-Scale Laboratory Measurements Of A Sandy Beach And Dynamic Cobble Berm Revetment, Chris E. Blenkinsopp, Paul M. Bayle, Daniel C. Conley, Gerd Masselink, Emily Gulson, Isabel Kelly, Rafael Almar, Ian L. Turner, Tom E. Baldock, Tomas Beuzen, Robert T. Mccall, Huub Rijper, Ad Reniers, Peter Troch, David Gallach-Sanchez, Alan J. Hunter, Oscar Bryan, Gwyn Hennessey, Peter Ganderton, Marion Tissier, Matthias Kudella, Stefan Schimmels
Author Correction: High-Resolution, Large-Scale Laboratory Measurements Of A Sandy Beach And Dynamic Cobble Berm Revetment, Chris E. Blenkinsopp, Paul M. Bayle, Daniel C. Conley, Gerd Masselink, Emily Gulson, Isabel Kelly, Rafael Almar, Ian L. Turner, Tom E. Baldock, Tomas Beuzen, Robert T. Mccall, Huub Rijper, Ad Reniers, Peter Troch, David Gallach-Sanchez, Alan J. Hunter, Oscar Bryan, Gwyn Hennessey, Peter Ganderton, Marion Tissier, Matthias Kudella, Stefan Schimmels
School of Biological and Marine Sciences
A Correction to this paper has been published: https://doi.org/10.1038/s41597-021-00874-2.
Targeting Ebola Virus Replication Through Pharmaceutical Intervention, Frederick Hansen, Heinz Feldmann, Michael A. Jarvis
Targeting Ebola Virus Replication Through Pharmaceutical Intervention, Frederick Hansen, Heinz Feldmann, Michael A. Jarvis
School of Biomedical Sciences
Introduction. The consistent emergence/reemergence of filoviruses into a world that previously lacked an approved pharmaceutical intervention parallels an experience repeatedly played-out for most other emerging pathogenic zoonotic viruses. Investment to preemptively develop effective and low-cost prophylactic and therapeutic interventions against viruses that have high potential for emergence and societal impact should be a priority.Areas covered. Candidate drugs can be characterized into those that interfere with cellular processes required for Ebola virus (EBOV) replication (host-directed), and those that directly target virally encoded functions (direct-acting). We discuss strategies to identify pharmaceutical interventions for EBOV infections. PubMed/Web of Science databases were searched to …
The Impact Of Ocean-Wave Coupling On The Upper Ocean Circulation During Storm Events, D Bruciaferri, M Tonani, H Lewis, J Siddorn, A Saulter, Jm Castillo, Valiente N Garcia, D Conley, P Sykes, I Ascione, N Mcconnell
The Impact Of Ocean-Wave Coupling On The Upper Ocean Circulation During Storm Events, D Bruciaferri, M Tonani, H Lewis, J Siddorn, A Saulter, Jm Castillo, Valiente N Garcia, D Conley, P Sykes, I Ascione, N Mcconnell
School of Biological and Marine Sciences
No abstract provided.
Context Aware Intelligent Mixing Systems, Mn Lefford, G Bromham, G Fazekas, D Moffat
Context Aware Intelligent Mixing Systems, Mn Lefford, G Bromham, G Fazekas, D Moffat
School of Engineering, Computing and Mathematics
Intelligent Mixing Systems (IMS) are rapidly becoming integrated into music mixing and production workflows. The intelligences of a human mixer and IMS can be distinguished by their abilities to comprehend, assess, and appreciate context. Humans will factor context into decisions, particularly concerning the use and application of technologies. The utility of an IMS depends on both its affordances and the situation in which it is to be used. The appropriate use for conventional purposes, or its utility for misappropriation, is determined by the context. This study considers how context impacts mixing decisions and the use of technology, focusing on how …
Combinatorial Mathematical Modelling Approaches To Interrogate Rear Retraction Dynamics In 3d Cell Migration, Joseph H.R. Hetmanski, Matthew C. Jones, Fatima Chunara, Jean Marc Schwartz, Patrick T. Caswell
Combinatorial Mathematical Modelling Approaches To Interrogate Rear Retraction Dynamics In 3d Cell Migration, Joseph H.R. Hetmanski, Matthew C. Jones, Fatima Chunara, Jean Marc Schwartz, Patrick T. Caswell
Peninsula Medical School
Cell migration in 3D microenvironments is a complex process which depends on the coordinated activity of leading edge protrusive force and rear retraction in a push-pull mechanism. While the potentiation of protrusions has been widely studied, the precise signalling and mechanical events that lead to retraction of the cell rear are much less well understood, particularly in physiological 3D extra-cellular matrix (ECM). We previously discovered that rear retraction in fast moving cells is a highly dynamic process involving the precise spatiotemporal interplay of mechanosensing by caveolae and signalling through RhoA. To further interrogate the dynamics of rear retraction, we have …
Development Of The Csomio Coupled Ocean-Oil-Sediment- Biology Model, Ds Dukhovskoy, Sl Morey, Ep Chassignet, Xu Chen, Vj Coles, L Cui, Ck Harris, R Hetland, T-J Hsu, Aj Manning, M Stukel, K Thyng, J Wang
Development Of The Csomio Coupled Ocean-Oil-Sediment- Biology Model, Ds Dukhovskoy, Sl Morey, Ep Chassignet, Xu Chen, Vj Coles, L Cui, Ck Harris, R Hetland, T-J Hsu, Aj Manning, M Stukel, K Thyng, J Wang
School of Biological and Marine Sciences
The fate and dispersal of oil in the ocean is dependent upon ocean dynamics, as well as transformations resulting from the interaction with the microbial community and suspended particles. These interaction processes are parameterized in many models limiting their ability to accurately simulate the fate and dispersal of oil for subsurface oil spill events. This paper presents a coupled ocean-oil-biology-sediment modeling system developed by the Consortium for Simulation of Oil-Microbial Interactions in the Ocean (CSOMIO) project. A key objective of the CSOMIO project was to develop and evaluate a modeling framework for simulating oil in the marine environment, including its …
The Role Of Biophysical Stickiness On Oil-Mineral Flocculation And Settling In Seawater, L Ye, Aj Manning, J Holyoke, Ja Penaloza-Giraldo, T-J Hsu
The Role Of Biophysical Stickiness On Oil-Mineral Flocculation And Settling In Seawater, L Ye, Aj Manning, J Holyoke, Ja Penaloza-Giraldo, T-J Hsu
School of Biological and Marine Sciences
Biophysical cohesive particles in aquatic systems, such as extracellular polymeric substances (EPS) and clay minerals, play an important role in determining the transport of spilled oil contamination and its eventual fate, particularly given that suspended sediment and microbial activities are often prevalent and diverse in natural environments. A series of stirring jar tests have been conducted to understand the multiple structures characteristics of the oil-mineral aggregates (OMAs) and EPS-oil-mineral aggregates (EPS-OMAs). OMAs and EPS-OMAs have been successfully generated in the laboratory within artificial seawater using: Texas crude oil (Dynamic viscosity: 7.27 × 10–3 Pa⋅s at 20°C), two natural clay minerals …
Sediment Supply Dampens The Erosive Effects Of Sea-Level Rise On Reef Islands, Megan E. Tuck, Murray R. Ford, Paul S. Kench, Gerd Masselink
Sediment Supply Dampens The Erosive Effects Of Sea-Level Rise On Reef Islands, Megan E. Tuck, Murray R. Ford, Paul S. Kench, Gerd Masselink
School of Biological and Marine Sciences
AbstractLarge uncertainty surrounds the future physical stability of low-lying coral reef islands due to a limited understanding of the geomorphic response of islands to changing environmental conditions. Physical and numerical modelling efforts have improved understanding of the modes and styles of island change in response to increasing wave and water level conditions. However, the impact of sediment supply on island morphodynamics has not been addressed and remains poorly understood. Here we present evidence from the first physical modelling experiments to explore the effect of storm-derived sediment supply on the geomorphic response of islands to changes in sea level and energetic …
Ocean Acidification Increases Phytobenthic Carbon Fixation And Export In A Warm-Temperate System, Shigeki Wada, Sylvain Agostini, Ben P. Harvey, Yuko Omori, Jason M. Hall-Spencer
Ocean Acidification Increases Phytobenthic Carbon Fixation And Export In A Warm-Temperate System, Shigeki Wada, Sylvain Agostini, Ben P. Harvey, Yuko Omori, Jason M. Hall-Spencer
School of Biological and Marine Sciences
No abstract provided.
Ecological Restoration Of Agricultural Land Can Improve Its Contribution To Economic Development, Adrian C. Newton, Paul M. Evans, Stephen C.L. Watson, Lucy E. Ridding, Steven Brand, Morag Mccracken, Arjan S. Gosal, James M. Bullock
Ecological Restoration Of Agricultural Land Can Improve Its Contribution To Economic Development, Adrian C. Newton, Paul M. Evans, Stephen C.L. Watson, Lucy E. Ridding, Steven Brand, Morag Mccracken, Arjan S. Gosal, James M. Bullock
Plymouth Business School
Given the negative environmental impacts of intensive agriculture, there is an urgent need to reduce the impact of food production on biodiversity. Ecological restoration of farmland could potentially contribute to this goal. While the positive impacts of ecological restoration on biodiversity are well established, less evidence is available regarding impacts on economic development and employment. Potentially, prospects for economic development could be enhanced by ecological restoration though increased provision of ecosystem services, on which some economic activity depends. Here we examined this issue through the development of contrasting land use scenarios for the county of Dorset, southern England. Two scenarios …
Drug Repurposing For Next-Generation Combination Therapies Against Multidrug-Resistant Bacteria, Yuan Liu, Ziwen Tong, Jingru Shi, Ruichao Li, Mathew Upton, Zhiqiang Wang
Drug Repurposing For Next-Generation Combination Therapies Against Multidrug-Resistant Bacteria, Yuan Liu, Ziwen Tong, Jingru Shi, Ruichao Li, Mathew Upton, Zhiqiang Wang
School of Biomedical Sciences
No abstract provided.
Gp Trainee Responses To Using Sherpa For Multimorbidity Consultations, Dawn R. Swancutt, Edmund Jack, Hilary A. Neve, John Tredinnick-Rowe, Nick Axford, Richard Byng
Gp Trainee Responses To Using Sherpa For Multimorbidity Consultations, Dawn R. Swancutt, Edmund Jack, Hilary A. Neve, John Tredinnick-Rowe, Nick Axford, Richard Byng
Peninsula Medical School
No abstract provided.
Towards Powerful Educational Knowledge? Addressing The Challenges Facing Educational Foundations, Curriculum Theory And Didaktik, Jim Hordern, Johan Muller, Zongyi Deng
Towards Powerful Educational Knowledge? Addressing The Challenges Facing Educational Foundations, Curriculum Theory And Didaktik, Jim Hordern, Johan Muller, Zongyi Deng
Plymouth Institute of Education
No abstract provided.
‘Off‐Rolling’ And Foucault’S Art Of Visibility/Invisibility: An Exploratory Study Of Senior Leaders’ Views Of ‘Strategic’ School Exclusion In Southwest England, Elizabeth J. Done, Helen Knowler
‘Off‐Rolling’ And Foucault’S Art Of Visibility/Invisibility: An Exploratory Study Of Senior Leaders’ Views Of ‘Strategic’ School Exclusion In Southwest England, Elizabeth J. Done, Helen Knowler
School of Law, Humanities and Social Sciences
This article reports an unprecedented exploratory small-scale investigation of the views of senior school leaders in southwest England relating to ‘off-rolling’ (illegal exclusionary practices). ‘Off-rolling’ is conceptualised as a policy technology, however, the conceptual framework used in data analysis derives from Foucault’s treatment of power and pleasure, and the constitution in discourse of novel ‘permanent realities’. Relations of force that senior school leaders routinely navigate in neoliberal education cultures characterised by ‘performativity’ are highlighted. The latter describes pressures to evidence efficiency and continual improvement, including high-stakes performance monitoring and, in England, a national school inspection regime. The response rate to …
Bridging The Gap: Using Reservoir Ecology And Human Serosurveys To Estimate Lassa Virus Spillover In West Africa, Andrew J. Basinski, Elisabeth Fichet-Calvet, Anna R. Sjodin, Tanner J. Varrelman, Christopher H. Remien, Nathan C. Layman, Brian H. Bird, David J. Wolking, Corina Monagin, Bruno M. Ghersi, Peter A. Barry, Michael A. Jarvis, Paul E. Gessler, Scott L. Nuismer
Bridging The Gap: Using Reservoir Ecology And Human Serosurveys To Estimate Lassa Virus Spillover In West Africa, Andrew J. Basinski, Elisabeth Fichet-Calvet, Anna R. Sjodin, Tanner J. Varrelman, Christopher H. Remien, Nathan C. Layman, Brian H. Bird, David J. Wolking, Corina Monagin, Bruno M. Ghersi, Peter A. Barry, Michael A. Jarvis, Paul E. Gessler, Scott L. Nuismer
School of Biomedical Sciences
Forecasting the risk of pathogen spillover from reservoir populations of wild or domestic animals is essential for the effective deployment of interventions such as wildlife vaccination or culling. Due to the sporadic nature of spillover events and limited availability of data, developing and validating robust, spatially explicit, predictions is challenging. Recent efforts have begun to make progress in this direction by capitalizing on machine learning methodologies. An important weakness of existing approaches, however, is that they generally rely on combining human and reservoir infection data during the training process and thus conflate risk attributable to the prevalence of the pathogen …
Comparison Between Centralised And Decentralised Supply Chain Of Autologous Car-T Therapies: A Uk Case Study Based On Discrete Event Simulation, Ching Lam, Edward Meinert, Aidong Yang, C Zhanfeng
Comparison Between Centralised And Decentralised Supply Chain Of Autologous Car-T Therapies: A Uk Case Study Based On Discrete Event Simulation, Ching Lam, Edward Meinert, Aidong Yang, C Zhanfeng
School of Nursing and Midwifery
Decentralised (or distributed) manufacturing that takes place close to the point of care has been a manufacturing paradigm of heightened interest within the cell therapy domain due to the product being living cell material and the need for highly monitored and temperature-controlled supply chain, which has the potential to benefit from the close proximity between manufacturing and application. To compare the operational feasibility and cost implications of manufacturing autologous CAR-T products between centralised and decentralised schemes, a discrete event simulation model was built using ExtendSIM 9 for simulating the patient-to-patient supply chain from the collection of patient cells to the …
The Neurology–Psychiatry Interface In Epilepsy, V Murphy, B Hallahan, H O’Connell, B Wright, Et Al
The Neurology–Psychiatry Interface In Epilepsy, V Murphy, B Hallahan, H O’Connell, B Wright, Et Al
Peninsula Medical School
Epilepsy and mental illness have a bidirectional association. Psychiatrists are likely to encounter epilepsy as comorbidity. Seizures may present as mental illness. Equally, the management of psychiatric conditions has the potential to destabilise epilepsy. There is a need for structured epilepsy awareness and training amongst psychiatrists. This paper outlines key considerations around diagnosis, treatment and risk while suggesting practical recommendations.
A Creative Destruction Approach To Replication: Implicit Work And Sex Morality Across Cultures, Warren Tierney, Jay Hardy, Charles R. Ebersole, Domenico Viganola, Elena Giulia Clemente, Michael Gordon, Suzanne Hoogeveen, Julia Haaf, Anna Dreber, Magnus Johannesson, Thomas Pfeiffer, Hanah Chapman, Ana Gantman, Matthew Vanaman, Kenneth Demarree, Eric R. Igou, Jordan Wylie, Justin Storbeck, Michael R. Andreychik, Jon Mcphetres, Leigh Ann Vaughn, Culture And Work Forecasting Collaboration, Eric Luis Uhlmann, E.L.
A Creative Destruction Approach To Replication: Implicit Work And Sex Morality Across Cultures, Warren Tierney, Jay Hardy, Charles R. Ebersole, Domenico Viganola, Elena Giulia Clemente, Michael Gordon, Suzanne Hoogeveen, Julia Haaf, Anna Dreber, Magnus Johannesson, Thomas Pfeiffer, Hanah Chapman, Ana Gantman, Matthew Vanaman, Kenneth Demarree, Eric R. Igou, Jordan Wylie, Justin Storbeck, Michael R. Andreychik, Jon Mcphetres, Leigh Ann Vaughn, Culture And Work Forecasting Collaboration, Eric Luis Uhlmann, E.L.
More Faculty of Health Research
How can we maximize what is learned from a replication study? In the creative destruction approach to replication, the original hypothesis is compared not only to the null hypothesis, but also to predictions derived from multiple alternative theoretical accounts of the phenomenon. To this end, new populations and measures are included in the design in addition to the original ones, to help determine which theory best accounts for the results across multiple key outcomes and contexts. The present pre-registered empirical project compared the Implicit Puritanism account of intuitive work and sex morality to theories positing regional, religious, and social class …
Do Positive Interactions Between Marine Invaders Increase Likelihood Of Invasion Into Natural And Artificial Habitats?, Louise B. Firth, Lois Duff, Paul E. Gribben, Antony M. Knights
Do Positive Interactions Between Marine Invaders Increase Likelihood Of Invasion Into Natural And Artificial Habitats?, Louise B. Firth, Lois Duff, Paul E. Gribben, Antony M. Knights
School of Biological and Marine Sciences
Positive species interactions such as facilitation are important for enabling species to persist, especially in stressful conditions, and the nature and strength of facilitation varies along physical and biological gradients. Expansion of coastal infrastructure is creating hotspots of invasive species which can spillover into natural habitats, but the role of positive species interactions associated with biological invasions remains understudied. Theory suggests that stronger biotic pressure in natural habitats inhibits invasion success. In space-limited marine systems, sessile organisms can overcome this limiting resource by settling as an epibiont on a substrate organism – basibiont. Using a series of spatially extensive surveys, …
Better For Whom? Leveling The Injustices Of International Conferences By Moving Online, Holly J. Niner, Sophia N. Wassermann
Better For Whom? Leveling The Injustices Of International Conferences By Moving Online, Holly J. Niner, Sophia N. Wassermann
School of Biological and Marine Sciences
International conferences are an important component of the professional calendar of scientists and practitioners in many fields, and are valued as opportunities to establish, create and foster networks, wellbeing and knowledge. The 2020 global pandemic, in prohibiting large gatherings and travel, has provided an opportunity to test the feasibility and implications of a shift from in-person to online conference formats. Avoiding international travel and associated bureaucracy, time and expense could overcome many of the historic injustices preventing many from participating in and benefiting from international conferences, and also avoid the emissions associated with international air travel. However, prior to 2020, …
Carbon Catabolite Repression In Filamentous Fungi Is Regulated By Phosphorylation Of The Transcription Factor Crea, Assis Lj De, Lp Silva, O Bayram, P Dowling, O Kniemeyer, T Krüger, Aa Brakhage, Yingying Chen, L Dong, K Tan, Kh Wong, Lna Ries, Gh Goldman
Carbon Catabolite Repression In Filamentous Fungi Is Regulated By Phosphorylation Of The Transcription Factor Crea, Assis Lj De, Lp Silva, O Bayram, P Dowling, O Kniemeyer, T Krüger, Aa Brakhage, Yingying Chen, L Dong, K Tan, Kh Wong, Lna Ries, Gh Goldman
Peninsula Medical School
In filamentous fungi, the transcription factor CreA controls carbohydrate metabolism through the regulation of genes encoding enzymes required for the use of alternative carbon sources. In this work, phosphorylation sites were identified on Aspergillus nidulans CreA, and subsequently, the two newly identified sites S268 and T308, the previously identified but uncharacterized site S262, and the previously characterized site S319 were chosen to be mutated to nonphosphorylatable residues before their effect on CCR was characterized.
Fat Mass Prediction Equations And Reference Ranges For Saudi Arabian Children Aged 8–12 Years Using Machine Technique Method, Rb Alkutbe, A Alruban, H Alturki, A Sattar, H Al-Hazzaa, G Rees
Fat Mass Prediction Equations And Reference Ranges For Saudi Arabian Children Aged 8–12 Years Using Machine Technique Method, Rb Alkutbe, A Alruban, H Alturki, A Sattar, H Al-Hazzaa, G Rees
School of Biomedical Sciences
Background The number of children with obesity has increased in Saudi Arabia, which is a significant public health concern. Early diagnosis of childhood obesity and screening of the prevalence is needed using a simple in situ method. This study aims to generate statistical equations to predict body fat percentage (BF%) for Saudi children by employing machine learning technology and to establish gender and age-specific body fat reference range. Methods Data was combined from two cross-sectional studies conducted in Saudi Arabia for 1,292 boys and girls aged 8–12 years. Body fat was measured in both studies using bio-electrical impedance analysis devices. …
Increasing Nutrient Stress Reduces The Efficiency Of Energy Transfer Through Planktonic Size Spectra, Angus Atkinson, Martin K.S. Lilley, Andrew G. Hirst, Andrea J. Mcevoy, Glen A. Tarran, Claire Widdicombe, Elaine S. Fileman, E. Malcolm S. Woodward, Katrin Schmidt, Tim J. Smyth, Paul J. Somerfield
Increasing Nutrient Stress Reduces The Efficiency Of Energy Transfer Through Planktonic Size Spectra, Angus Atkinson, Martin K.S. Lilley, Andrew G. Hirst, Andrea J. Mcevoy, Glen A. Tarran, Claire Widdicombe, Elaine S. Fileman, E. Malcolm S. Woodward, Katrin Schmidt, Tim J. Smyth, Paul J. Somerfield
School of Geography, Earth and Environmental Sciences
Size-spectral approaches quantify the efficiency of energy transfer through food webs, but theory and field studies disagree over how changes in temperature, nutrients, and extreme weather impact on this efficiency. We address this at two scales: via 6 years of weekly sampling of the plankton size spectrum at the Plymouth L4 shelf sea site, and via a new, global-scale, meta-analysis of aquatic size spectra. The time series showed that with summertime nutrient starvation, the energy transfer efficiency from picoplankton to macroplankton decreased (i.e., steepening slopes of the size spectra). This reflected increasing dominance by small cells and their microbial consumers. …
The Future Of Our Seas: Marine Scientists And Creative Professionals Collaborate For Science Communication, Laurence De Clippele*, Madlaina Michelotti, Charlotte R. Findlay, Amy Cartwright, Qing Fang, Charlie Wheatly, Ashleigh Sladen, Kes Scott-Somme, Harry R. Harding, Juliette Jackson, Laura E. Hepburn, Jessica Giannotti, Grace Carroll, Nicole Heidtke, Alison M. Worrall, Kris De Meyer
The Future Of Our Seas: Marine Scientists And Creative Professionals Collaborate For Science Communication, Laurence De Clippele*, Madlaina Michelotti, Charlotte R. Findlay, Amy Cartwright, Qing Fang, Charlie Wheatly, Ashleigh Sladen, Kes Scott-Somme, Harry R. Harding, Juliette Jackson, Laura E. Hepburn, Jessica Giannotti, Grace Carroll, Nicole Heidtke, Alison M. Worrall, Kris De Meyer
School of Biological and Marine Sciences
To increase awareness of the current challenges facing the marine environment,the Future of Our Seas (FOOS) project brought together the expertise ofscientists, public engagement experts and creatives to train and support agroup of marine scientists in effective science communication and innovativepublic engagement. This case study aims to inspire scientists and artists touse the FOOS approach in training, activity design and development support(hereafter called the ‘FOOS programme’) to collaboratively deliver noveland creative engagement activities. The authors reflect on the experiencesof the marine scientists: (1) attending the FOOS communication andengagement training; (2) creating and delivering public engagement activities;(3) understanding our audience; and …
Lead In Plastics – Recycling Of Legacy Material And Appropriateness Of Current Regulations, Andrew Turner, Montserrat Filella
Lead In Plastics – Recycling Of Legacy Material And Appropriateness Of Current Regulations, Andrew Turner, Montserrat Filella
School of Geography, Earth and Environmental Sciences
No abstract provided.
Aesthetically Designing Video-Call Technology With Care Home Residents: A Focus Group Study, Sonam Zamir, Felicity Allman, Catherine Hagan Hennessy, Adrian Haffner Taylor, Ray Brian Jones
Aesthetically Designing Video-Call Technology With Care Home Residents: A Focus Group Study, Sonam Zamir, Felicity Allman, Catherine Hagan Hennessy, Adrian Haffner Taylor, Ray Brian Jones
Peninsula Medical School
BackgroundVideo-calls have proven to be useful for older care home residents in improving socialization and reducing loneliness. Nonetheless, to facilitate the acceptability and usability of a new technological intervention, especially among people with dementia, there is a need for user-led design improvements. The current study conducted focus groups with an embedded activity with older people to allow for a person-centered design of a video-call intervention.MethodsTwenty-eight residents across four care homes in the South West of England participated in focus groups to aesthetically personalize and ‘dress-up’ the equipment used in a video-call intervention. Each care home was provided with a ‘Skype …
Evidence For The Effects Of Decommissioning Man-Made Structures On Marine Ecosystems Globally: A Systematic Map Protocol, Anaëlle J. Lemasson, Antony M. Knights, Murray Thompson, Gennadi Lessin, Nicola Beaumont, Christine Pascoe, Ana M. Queirós, Louise Mcneill, Michaela Schratzberger, Paul J. Somerfield
Evidence For The Effects Of Decommissioning Man-Made Structures On Marine Ecosystems Globally: A Systematic Map Protocol, Anaëlle J. Lemasson, Antony M. Knights, Murray Thompson, Gennadi Lessin, Nicola Beaumont, Christine Pascoe, Ana M. Queirós, Louise Mcneill, Michaela Schratzberger, Paul J. Somerfield
School of Biological and Marine Sciences
Background: Numerous man-made structures (MMS) have been installed in various parts of the ocean (e.g. oil and gas structures, offshore wind installations). Many are now at, or nearing, the end of their intended life. Currently, we only have a limited understanding of decommissioning effects. In many locations, such as the North Sea, regulations restrict decommissioning options to complete removal, with little consideration of alternative management options might offer. To generate a reliable evidence-base to inform the decision-making processes pertaining to marine MMS management, we propose a wide-encompassing systematic map of published research on the ecosystem effects (including ecosystem services) of …
Variability In Carbapenemase Activity Of Intrinsic Oxaab (Oxa-51-Like) Β-Lactamase Enzymes In Acinetobacter Baumannii., Yuiko Takebayashi, Jacqueline Findlay, Kate J. Heesom, Philip J. Warburton, Matthew B. Avison, Benjamin A. Evans
Variability In Carbapenemase Activity Of Intrinsic Oxaab (Oxa-51-Like) Β-Lactamase Enzymes In Acinetobacter Baumannii., Yuiko Takebayashi, Jacqueline Findlay, Kate J. Heesom, Philip J. Warburton, Matthew B. Avison, Benjamin A. Evans
School of Biomedical Sciences
OBJECTIVES: To measure the variability in carbapenem susceptibility conferred by different OxaAb variants, characterize the molecular evolution of oxaAb and elucidate the contribution of OxaAb and other possible carbapenem resistance factors in the clinical isolates using WGS and LC-MS/MS. METHODS: Antimicrobial susceptibility tests were performed on 10 clinical Acinetobacter baumannii isolates. Carbapenem MICs were evaluated for all oxaAb variants cloned into A. baumannii CIP70.10 and BM4547, with and without their natural promoters. Molecular evolution analysis of the oxaAb variants was performed using FastTree and SplitsTree4. Resistance determinants were studied in the clinical isolates using WGS and LC-MS/MS. RESULTS: Only the …
Antagonistic Cytoprotective Effects Of C60 Fullerene Nanoparticles In Simultaneous Exposure To Benzo[A]Pyrene In A Molluscan Animal Model, Awadhesh N. Jha
Antagonistic Cytoprotective Effects Of C60 Fullerene Nanoparticles In Simultaneous Exposure To Benzo[A]Pyrene In A Molluscan Animal Model, Awadhesh N. Jha
School of Biological and Marine Sciences
The hypothesis that C60 fullerene nanoparticles (C60) exert an antagonistic interactive effect on the toxicity of benzo[a]pyrene (BaP) has been supported by this investigation. Mussels were exposed to BaP (5, 50 & 100 μg/L) and C60 (C60–1 mg/L) separately and in combination. Both BaP and C60 were shown to co-localize in the secondary lysosomes of the hepatopancreatic digestive cells in the digestive gland where they reduced lysosomal membrane stability (LMS) or increased membrane permeability, while BaP also induced increased lysosomal lipid and lipofuscin, indicative of oxidative cell injury and autophagic dysfunction. Combinations of BaP and C60 showed antagonistic effects for …