Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Plymouth

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 2191 - 2220 of 6794

Full-Text Articles in Entire DC Network

Mastomys Natalensis Has A Cellular Immune Response Profile Distinct From Laboratory Mice, Tsing Lee Tang-Huau, Kyle Rosenke, Kimberly Meade-White, Aaron Carmody, Brian J. Smith, Catharine M. Bosio, Michael A. Jarvis, Heinz Feldmann Apr 2021

Mastomys Natalensis Has A Cellular Immune Response Profile Distinct From Laboratory Mice, Tsing Lee Tang-Huau, Kyle Rosenke, Kimberly Meade-White, Aaron Carmody, Brian J. Smith, Catharine M. Bosio, Michael A. Jarvis, Heinz Feldmann

School of Biomedical Sciences

The multimammate mouse (Mastomys natalensis; M. natalensis) has been identified as a major reservoir for multiple human pathogens including Lassa virus (LASV), Leishmania spp., Yersinia spp., and Borrelia spp. Although M. natalensis are related to well-characterized mouse and rat species commonly used in laboratory models, there is an absence of established assays and reagents to study the host immune responses of M. natalensis. As a result, there are major limitations to our understanding of immunopathology and mechanisms of immunological pathogen control in this increasingly important rodent species. In the current study, a large panel of commercially available rodent reagents were …


Skilful Mating? Insights From Animal Contest Research, Sarah M. Lane, Mark Briffa Apr 2021

Skilful Mating? Insights From Animal Contest Research, Sarah M. Lane, Mark Briffa

School of Biological and Marine Sciences

No abstract provided.


A Review Of Network And Computer Analysis Of Epileptiform Discharge Free Eeg To Characterize And Detect Epilepsy, Caitlin West, Wessel Woldman, Katy Oak, Brendan Mclean, Rohit Shankar Apr 2021

A Review Of Network And Computer Analysis Of Epileptiform Discharge Free Eeg To Characterize And Detect Epilepsy, Caitlin West, Wessel Woldman, Katy Oak, Brendan Mclean, Rohit Shankar

Peninsula Medical School

Objectives. There is emerging evidence that network/computer analysis of epileptiform discharge free electroencephalograms (EEGs) can be used to detect epilepsy, improve diagnosis and resource use. Such methods are automated and can be performed on shorter recordings of EEG. We assess the evidence and its strength in the area of seizure detection from network/computer analysis of epileptiform discharge free EEG. Methods. A scoping review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance was conducted with a literature search of Embase, Medline and PsychINFO. Predesigned inclusion/exclusion criteria were applied to selected articles. Results. The initial search found 3398 articles. …


Uptake, Accumulation And Impact Of Antiretroviral And Antiviral Pharmaceutical Compounds In Lettuce, Preston Akenga, Antony Gachanja, Mark F. Fitzsimons, Alan Tappin, Sean Comber Apr 2021

Uptake, Accumulation And Impact Of Antiretroviral And Antiviral Pharmaceutical Compounds In Lettuce, Preston Akenga, Antony Gachanja, Mark F. Fitzsimons, Alan Tappin, Sean Comber

School of Geography, Earth and Environmental Sciences

No abstract provided.


Sea Cucumber-Derived Peptides Alleviate Oxidative Stress In Neuroblastoma Cells And Improve Survival In C. Elegans Exposed To Neurotoxic Paraquat, Meng Lu, Ajay Mishra, Chiara Boschetti, Jing Lin, Yushuang Liu, H Huang, Clemens F. Kaminski, Z Huang, Alan Tunnacliffe, Clemens F. Kaminski Apr 2021

Sea Cucumber-Derived Peptides Alleviate Oxidative Stress In Neuroblastoma Cells And Improve Survival In C. Elegans Exposed To Neurotoxic Paraquat, Meng Lu, Ajay Mishra, Chiara Boschetti, Jing Lin, Yushuang Liu, H Huang, Clemens F. Kaminski, Z Huang, Alan Tunnacliffe, Clemens F. Kaminski

School of Biological and Marine Sciences

Oxidative stress results when the production of oxidants outweighs the capacity of the antioxidant defence mechanisms. This can lead to pathological conditions including cancer and neurodegeneration. Consequently, there is considerable interest in compounds with antioxidant activity, including those from natural sources. Here, we characterise the antioxidant activity of three novel peptides identified in protein hydrolysates from the sea cucumber Apostichopus japonicus. Under oxidative stress conditions, synthetic versions of the sea cucumber peptides significantly compensate for glutathione depletion, decrease mitochondrial superoxide levels, and alleviate mitophagy in human neuroblastoma cells. Moreover, orally supplied peptides improve survival of the Caenorhabditis elegans after treatment …


Ocean Acidification Locks Algal Communities In A Species‐Poor Early Successional Stage, Ben P. Harvey, Koetsu Kon, Sylvain Agostini, Shigeki Wada, Jm Hall‐Spencer Apr 2021

Ocean Acidification Locks Algal Communities In A Species‐Poor Early Successional Stage, Ben P. Harvey, Koetsu Kon, Sylvain Agostini, Shigeki Wada, Jm Hall‐Spencer

School of Biological and Marine Sciences

Long-term exposure to CO2-enriched waters can considerably alter marine biological community development, often resulting in simplified systems dominated by turf algae that possess reduced biodiversity and low ecological complexity. Current understanding of the underlying processes by which ocean acidification alters biological community development and stability remains limited, making the management of such shifts problematic. Here, we deployed recruitment tiles in reference (pHT 8.137 ± 0.056 SD) and CO2-enriched conditions (pHT 7.788 ± 0.105 SD) at a volcanic CO2 seep in Japan to assess the underlying processes and patterns of algal community development. We assessed (i) algal community succession in two …


Orally Delivered Mk-4482 Inhibits Sars-Cov-2 Replication In The Syrian Hamster Model, K Rosenke, Frederick Hansen, Benjamin Schwarz, F Feldmann, Elaine Haddock, R Rosenke, Kent Barbian, Kimberly Meade-White, Atsushi Okumura, Shanna Leventhal, David W. Hawman, Emily Ricotta, Catharine M. Bosio, Craig Martens, Greg Saturday, H Feldmann, Michael A. Jarvis Apr 2021

Orally Delivered Mk-4482 Inhibits Sars-Cov-2 Replication In The Syrian Hamster Model, K Rosenke, Frederick Hansen, Benjamin Schwarz, F Feldmann, Elaine Haddock, R Rosenke, Kent Barbian, Kimberly Meade-White, Atsushi Okumura, Shanna Leventhal, David W. Hawman, Emily Ricotta, Catharine M. Bosio, Craig Martens, Greg Saturday, H Feldmann, Michael A. Jarvis

School of Biomedical Sciences

AbstractThe COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic. Herein, we show that MK-4482, an orally administered nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model. The inhibitory effect of MK-4482 on SARS-CoV-2 replication is observed in animals when the drug is administered either beginning 12 h before or 12 h following infection in a high-risk exposure model. These data support the potential utility of MK-4482 to control SARS-CoV-2 infection in humans …


Spatial Distribution Of Sediment Phosphorus In A Ramsar Wetland, Ry Crocker, William H. Blake, Thomas H. Hutchinson, Sean Comber Apr 2021

Spatial Distribution Of Sediment Phosphorus In A Ramsar Wetland, Ry Crocker, William H. Blake, Thomas H. Hutchinson, Sean Comber

School of Geography, Earth and Environmental Sciences

No abstract provided.


Mapping Past Human Land Use Using Archaeological Data: A New Classification For Global Land Use Synthesis And Data Harmonization, Kd Morrison, E Hammer, O Boles, Et Al Apr 2021

Mapping Past Human Land Use Using Archaeological Data: A New Classification For Global Land Use Synthesis And Data Harmonization, Kd Morrison, E Hammer, O Boles, Et Al

School of Geography, Earth and Environmental Sciences

In the 12,000 years preceding the Industrial Revolution, human activities led to significant changes in land cover, plant and animal distributions, surface hydrology, and biochemical cycles. Earth system models suggest that this anthropogenic land cover change influenced regional and global climate. However, the representation of past land use in earth system models is currently oversimplified. As a result, there are large uncertainties in the current understanding of the past and current state of the earth system. In order to improve representation of the variety and scale of impacts that past land use had on the earth system, a global effort …


Biocide Use In The Antimicrobial Era: A Review, Imogen Anne Jones, Lovleen Tina Joshi Apr 2021

Biocide Use In The Antimicrobial Era: A Review, Imogen Anne Jones, Lovleen Tina Joshi

Peninsula Dental School

Biocides are widely used in healthcare and industry to control infections and microbial contamination. Ineffectual disinfection of surfaces and inappropriate use of biocides can result in the survival of microorganisms such as bacteria and viruses on inanimate surfaces, often contributing to the transmission of infectious agents. Biocidal disinfectants employ varying modes of action to kill microorganisms, ranging from oxidization to solubilizing lipids. This review considers the main biocides used within healthcare and industry environments and highlights their modes of action, efficacy and relevance to disinfection of pathogenic bacteria. This information is vital for rational use and development of biocides in …


A Label-Free Dna-Immunosensor Based On Aminated Rgo Electrode For The Quantification Of Dna Methylation, Mina Safarzadeh, Ahmed Suhail, Jagriti Sethi, Anas Sattar, David Jenkins, Genhua Pan Apr 2021

A Label-Free Dna-Immunosensor Based On Aminated Rgo Electrode For The Quantification Of Dna Methylation, Mina Safarzadeh, Ahmed Suhail, Jagriti Sethi, Anas Sattar, David Jenkins, Genhua Pan

School of Engineering, Computing and Mathematics

In this work, we developed a sandwich DNA-immunosensor for quantification of the methylated tumour suppressor gene O-6-methylguanine-DNA methyltransferase (MGMT), which is a potential biomarker for brain tumours and breast cancer. The biosensor is based on aminated reduced graphene oxide electrode, which is achieved by ammonium hydroxide chemisorption and anti-5-methylcytosine (anti-5mC) as a methylation bioreceptor. The target single-strand (ss) MGMT oligonucleotide is first recognised by its hybridisation with complementary DNA to form double-stranded (ds) MGMT, which is then captured by anti-5mC on the electrode surface due to the presence of methylation. Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and Scanning electron microscopy …


Current Trends And Challenges For Rapid Smart Diagnostics At Point-Of-Site Testing For Marine Toxins, Michael Dillon, Maja A. Zaczek-Moczydlowska, Christine Edwards, Andrew D. Turner, Peter I. Miller, Heather Moore, April Mckinney, Linda Lawton, Katrina Campbell Apr 2021

Current Trends And Challenges For Rapid Smart Diagnostics At Point-Of-Site Testing For Marine Toxins, Michael Dillon, Maja A. Zaczek-Moczydlowska, Christine Edwards, Andrew D. Turner, Peter I. Miller, Heather Moore, April Mckinney, Linda Lawton, Katrina Campbell

Peninsula Medical School

In the past twenty years marine biotoxin analysis in routine regulatory monitoring has advanced significantly in Europe (EU) and other regions from the use of the mouse bioassay (MBA) towards the high-end analytical techniques such as high-performance liquid chromatography (HPLC) with tandem mass spectrometry (MS). Previously, acceptance of these advanced methods, in progressing away from the MBA, was hindered by a lack of commercial certified analytical standards for method development and validation. This has now been addressed whereby the availability of a wide range of analytical standards from several companies in the EU, North America and Asia has enhanced the …


#Eegmanylabs: Investigating The Replicability Of Influential Eeg Experiments, Yuri G. Pavlov, Nika Adamian, Stefan Appelhoff, Mahnaz Arvaneh, Christopher S.Y. Benwell, Christian Beste, Amy R. Bland, Daniel E. Bradford, Florian Bublatzky, Niko A. Busch, Peter E. Clayson, Damian Cruse, Artur Czeszumski, Anna Dreber, Guillaume Dumas, Benedikt Ehinger, Giorgio Ganis, Xun He, José A. Hinojosa, Christoph Huber-Huber, Michael Inzlicht, Bradley N. Jack, Magnus Johannesson, Rhiannon Jones, Evgenii Kalenkovich, Laura Kaltwasser, Hamid Karimi-Rouzbahani, Andreas Keil, Peter König, Peter König Apr 2021

#Eegmanylabs: Investigating The Replicability Of Influential Eeg Experiments, Yuri G. Pavlov, Nika Adamian, Stefan Appelhoff, Mahnaz Arvaneh, Christopher S.Y. Benwell, Christian Beste, Amy R. Bland, Daniel E. Bradford, Florian Bublatzky, Niko A. Busch, Peter E. Clayson, Damian Cruse, Artur Czeszumski, Anna Dreber, Guillaume Dumas, Benedikt Ehinger, Giorgio Ganis, Xun He, José A. Hinojosa, Christoph Huber-Huber, Michael Inzlicht, Bradley N. Jack, Magnus Johannesson, Rhiannon Jones, Evgenii Kalenkovich, Laura Kaltwasser, Hamid Karimi-Rouzbahani, Andreas Keil, Peter König, Peter König

School of Psychology

No abstract provided.


The Abundance And Characteristics Of Microplastics In Surface Water In The Transboundary Ganges River, Imogen E. Napper, Anju Baroth, Aaron C. Barrett, Sunanda Bhola, Gawsia W. Chowdhury, Bede F.R. Davies, Emily M. Duncan, Sumit Kumar, Sarah E. Nelms, Niloy Mn Hasan, Bushra Nishat, Taylor Maddalene, Richard C. Thompson, Heather Koldewey Apr 2021

The Abundance And Characteristics Of Microplastics In Surface Water In The Transboundary Ganges River, Imogen E. Napper, Anju Baroth, Aaron C. Barrett, Sunanda Bhola, Gawsia W. Chowdhury, Bede F.R. Davies, Emily M. Duncan, Sumit Kumar, Sarah E. Nelms, Niloy Mn Hasan, Bushra Nishat, Taylor Maddalene, Richard C. Thompson, Heather Koldewey

School of Biological and Marine Sciences

No abstract provided.


Specific Niche Requirements Underpin Multidecadal Range Edge Stability, But May Introduce Barriers For Climate Change Adaptation, Louise B. Firth, Daniel Harris, Julie A. Blaze, Martin P. Marzloff, Aurélien Boyé, Peter I. Miller, Amelia Curd, Mickaël Vasquez, Julia D. Nunn, Nessa E. O’Connor, Anne Marie Power, Nova Mieszkowska, Ruth M. O’Riordan, Michael T. Burrows, Lucy M. Bricheno, Antony M. Knights, Flavia L.D. Nunes, François Bordeyne, Laura E. Bush, James E. Byers, Carmen David, Andrew J. Davies, Stanislas F. Dubois, Hugh Edwards, Andy Foggo, Lisa Grant, J. A.Mattias Green, Paul E. Gribben, Fernando P. Lima, David Mcgrath Apr 2021

Specific Niche Requirements Underpin Multidecadal Range Edge Stability, But May Introduce Barriers For Climate Change Adaptation, Louise B. Firth, Daniel Harris, Julie A. Blaze, Martin P. Marzloff, Aurélien Boyé, Peter I. Miller, Amelia Curd, Mickaël Vasquez, Julia D. Nunn, Nessa E. O’Connor, Anne Marie Power, Nova Mieszkowska, Ruth M. O’Riordan, Michael T. Burrows, Lucy M. Bricheno, Antony M. Knights, Flavia L.D. Nunes, François Bordeyne, Laura E. Bush, James E. Byers, Carmen David, Andrew J. Davies, Stanislas F. Dubois, Hugh Edwards, Andy Foggo, Lisa Grant, J. A.Mattias Green, Paul E. Gribben, Fernando P. Lima, David Mcgrath

School of Biological and Marine Sciences

Aim: To investigate some of the environmental variables underpinning the past and present distribution of an ecosystem engineer near its poleward range edge. Location: >500 locations spanning >7,400 km around Ireland. Methods: We collated past and present distribution records on a known climate change indicator, the reef-forming worm Sabellaria alveolata (Linnaeus, 1767) in a biogeographic boundary region over 182 years (1836–2018). This included repeat sampling of 60 locations in the cooler 1950s and again in the warmer 2000s and 2010s. Using species distribution modelling, we identified some of the environmental drivers that likely underpin S. alveolata distribution towards the leading …


Design In Engineering: An Evaluation Of Civilian And Military Unmanned Aerial Vehicle Platforms, Considering Smart Sensing With Ethical Design To Embody Mitigation Against Asymmetric Hostile Actor Exploitation, C Lavers Apr 2021

Design In Engineering: An Evaluation Of Civilian And Military Unmanned Aerial Vehicle Platforms, Considering Smart Sensing With Ethical Design To Embody Mitigation Against Asymmetric Hostile Actor Exploitation, C Lavers

School of Engineering, Computing and Mathematics

This report is written in part-fulfilment of personal output criteria for the Visiting Research Fellowship (Sir Richard Grenville Fellowship) at the Changing Character of War Centre, Pembroke College, Oxford, and the Centre for Sea Power and Strategy, Britannia Royal Naval College, Plymouth University at BRNC, Dartmouth. In this report I undertook an extensive analysis of the maritime UAV platform systems sector of a wide range of upstream manufacturing industry and downstream end user stakeholders. I consulted a global range of military and civilian users, to inform discussions around civilian UAV platforms which could be modified by hostile non-state actors, with …


Machine Learning Analysis Of Speech And Egg For The Diagnosis Of Voice Pathology, I Howard Mar 2021

Machine Learning Analysis Of Speech And Egg For The Diagnosis Of Voice Pathology, I Howard

School of Engineering, Computing and Mathematics

No abstract provided.


Predicting The Severity Of The Grass Pollen Season And The Effect Of Climate Change In Northwest Europe, A Kurganskiy, S Creer, N De Vere, The Pollergen Consortium, Et Al Mar 2021

Predicting The Severity Of The Grass Pollen Season And The Effect Of Climate Change In Northwest Europe, A Kurganskiy, S Creer, N De Vere, The Pollergen Consortium, Et Al

School of Geography, Earth and Environmental Sciences

Hay fever patients can be helped in managing their symptoms by predicting the severity of the upcoming grass pollen seasons.


Applications Of Microwave Energy In Medicine, Alexandra Gartshore, Matt Kidd, Lovleen Tina Joshi Mar 2021

Applications Of Microwave Energy In Medicine, Alexandra Gartshore, Matt Kidd, Lovleen Tina Joshi

Peninsula Dental School

Microwaves are a highly utilized electromagnetic wave, used across a range of industries including food processing, communications, in the development of novel medical treatments and biosensor diagnostics. Microwaves have known thermal interactions and theorized non-thermal interactions with living matter; however, there is significant debate as to the mechanisms of action behind these interactions and the potential benefits and limitations of their use. This review summarizes the current knowledge surrounding the implementation of microwave technologies within the medical industry.


Graphene Fet Sensors For Alzheimer’S Disease Protein Biomarker Clusterin Detection, Theodore Bungon, Carrie Haslam, Samar Damiati, Benjamin O’Driscoll, Toby Whitley, Paul Davey, Giuliano Siligardi, Jerome Charmet, Shakil A. Awan Mar 2021

Graphene Fet Sensors For Alzheimer’S Disease Protein Biomarker Clusterin Detection, Theodore Bungon, Carrie Haslam, Samar Damiati, Benjamin O’Driscoll, Toby Whitley, Paul Davey, Giuliano Siligardi, Jerome Charmet, Shakil A. Awan

School of Engineering, Computing and Mathematics

We report on the fabrication and characterisation of graphene field-effect transistor (GFET) biosensors for the detection of Clusterin, a prominent protein biomarker of Alzheimer’s disease (AD). The GFET sensors were fabricated on Si/SiO2 substrate using photolithographic patterning and metal lift-off techniques with evaporated chromium and sputtered gold contacts. Raman Spectroscopy was performed on the devices to determine the quality of the graphene. The GFETs were annealed to improve their performance before the channels were functionalized by immobilising the graphene surface with linker molecules and anti-Clusterin antibodies. Concentration of linker molecules was also independently verified by absorption spectroscopy using the …


Winter Carnivory And Diapause Counteract The Reliance On Ice Algae By Barents Sea Zooplankton, Doreen Kohlbach, Katrin Schmidt, Haakon Hop, Anette Wold, Amalia Keck Al-Habahbeh, Simon T. Belt, Matthias Woll, Martin Graeve, Lukas Smik, Angus Atkinson, Philipp Assmy Mar 2021

Winter Carnivory And Diapause Counteract The Reliance On Ice Algae By Barents Sea Zooplankton, Doreen Kohlbach, Katrin Schmidt, Haakon Hop, Anette Wold, Amalia Keck Al-Habahbeh, Simon T. Belt, Matthias Woll, Martin Graeve, Lukas Smik, Angus Atkinson, Philipp Assmy

School of Geography, Earth and Environmental Sciences

jats:p>The Barents Sea is a hotspot for environmental change due to its rapid warming, and information on dietary preferences of zooplankton is crucial to better understand the impacts of these changes on food-web dynamics. We combined lipid-based trophic marker approaches, namely analysis of fatty acids (FAs), highly branched isoprenoids (HBIs) and sterols, to compare late summer (August) and early winter (November/December) feeding of key Barents Sea zooplankters; the copepods Calanus glacialis, C. hyperboreus and C. finmarchicus and the amphipods Themisto libellula and T. abyssorum. Based on FAs, copepods showed a stronger reliance on a diatom-based diet. Phytosterols, produced mainly …


Cracked Tooth Syndrome: Assessment, Prognosis And Predictable Management Strategies., T Gill, Aj Pollard, J Baker, C Tredwin Mar 2021

Cracked Tooth Syndrome: Assessment, Prognosis And Predictable Management Strategies., T Gill, Aj Pollard, J Baker, C Tredwin

Peninsula Dental School

Cracked tooth syndrome (CTS) is a common presentation in general practice. The diagnosis and management of teeth with CTS may be difficult due to the unknown extent of the crack. This article reviews the aetiology, diagnosis, management and prognosis of teeth with CTS. A thorough examination is required to effectively assess CTS. Intervention should aim to relieve symptoms and brace the remaining tooth structure effectively against further flexion. Restored teeth with CTS have a guarded prognosis due to the risk of further crack propagation, but the chances of survival at 5-years is acceptable (74.1-96.8%).


Fine-Scale Oceanographic Drivers Of Reef Manta Ray (Mobula Alfredi) Visitation Patterns At A Feeding Aggregation Site, Joanna L. Harris, Phil Hosegood, Edward Robinson, Clare B. Embling, Simon Hilbourne, Guy M.W. Stevens Mar 2021

Fine-Scale Oceanographic Drivers Of Reef Manta Ray (Mobula Alfredi) Visitation Patterns At A Feeding Aggregation Site, Joanna L. Harris, Phil Hosegood, Edward Robinson, Clare B. Embling, Simon Hilbourne, Guy M.W. Stevens

School of Biological and Marine Sciences

No abstract provided.


Eukaryotic Community Composition In The Sea Surface Microlayer Across An East–West Transect In The Mediterranean Sea, Birthe Zäncker, Michael Cunliffe, Anja Engel Mar 2021

Eukaryotic Community Composition In The Sea Surface Microlayer Across An East–West Transect In The Mediterranean Sea, Birthe Zäncker, Michael Cunliffe, Anja Engel

School of Biological and Marine Sciences

Abstract. The sea surface microlayer (SML) represents the boundary layer at the air–sea interface. Microbial eukaryotes in the SML potentially influence air–sea gas exchange directly by taking up and producing gases and indirectly by excreting and degrading organic matter, which may modify the viscoelastic properties of the SML. However, little is known about the distribution of microbial eukaryotes in the SML. We studied the composition of the microbial community, transparent exopolymer particles and polysaccharides in the SML during the PEACETIME cruise along a west–east transect in the Mediterranean Sea, covering the western basin, Tyrrhenian Sea and Ionian Sea. At the …


Single Cell Transcriptome Data Analysis Defines The Heterogeneity Of Peripheral Nerve Cells In Homeostasis And Regeneration, Bing Chen, Matthew C. Banton, Lolita Singh, David B. Parkinson, Xin Peng Dun Mar 2021

Single Cell Transcriptome Data Analysis Defines The Heterogeneity Of Peripheral Nerve Cells In Homeostasis And Regeneration, Bing Chen, Matthew C. Banton, Lolita Singh, David B. Parkinson, Xin Peng Dun

School of Biomedical Sciences

The advances in single-cell RNA sequencing technologies and the development of bioinformatics pipelines enable us to more accurately define the heterogeneity of cell types in a selected tissue. In this report, we re-analyzed recently published single-cell RNA sequencing data sets and provide a rationale to redefine the heterogeneity of cells in both intact and injured mouse peripheral nerves. Our analysis showed that, in both intact and injured peripheral nerves, cells could be functionally classified into four categories: Schwann cells, nerve fibroblasts, immune cells, and cells associated with blood vessels. Nerve fibroblasts could be sub-clustered into epineurial, perineurial, and endoneurial fibroblasts. …


Bucking The Trend Of Pollinator Decline: The Population Genetics Of A Range Expanding Bumblebee, J. V. Huml, J. S. Ellis, K. Lloyd, C. M. Benefer, M. Kiernan, M. J.F. Brown, M. E. Knight Mar 2021

Bucking The Trend Of Pollinator Decline: The Population Genetics Of A Range Expanding Bumblebee, J. V. Huml, J. S. Ellis, K. Lloyd, C. M. Benefer, M. Kiernan, M. J.F. Brown, M. E. Knight

School of Biological and Marine Sciences

No abstract provided.


Root Canal Filling Quality Comparison Of A Premixed Calcium Silicate Endodontic Sealer And Different Carrier-Based Obturation Systems, R Pérez-Alfayate, M Mercade, J Algar-Pinilla, R Cisneros-Cabello, F Foschi, S Cohen Mar 2021

Root Canal Filling Quality Comparison Of A Premixed Calcium Silicate Endodontic Sealer And Different Carrier-Based Obturation Systems, R Pérez-Alfayate, M Mercade, J Algar-Pinilla, R Cisneros-Cabello, F Foschi, S Cohen

Peninsula Dental School

Background: The number of voids within the root canal obturation is a relevant parameter to describe the quality of the technique, as well as to predict long-term prognosis. The aim of this study was to evaluate the quality of root canal obturation in curved root canals filled with Thermafil, GuttaCore, GuttaFusion and lateral compaction with AH Plus and EndoSequence BC sealer, by means of percentage of gutta-percha and sealer filled area. Methods: 200 curved canals of mandibular molars were divided in five groups (n = 40). Each specimen was evaluated at 3, 6 and 9 mm from the apex. A …


Representing Uncertainty In The Rescorla-Wagner Model: Blocking, The Redundancy Effect, And Outcome Base Rate, Sg Spicer, Aj Wills, Pm Jones, Cj Mitchell, L Dome Mar 2021

Representing Uncertainty In The Rescorla-Wagner Model: Blocking, The Redundancy Effect, And Outcome Base Rate, Sg Spicer, Aj Wills, Pm Jones, Cj Mitchell, L Dome

Peninsula Medical School

It is generally assumed that the Rescorla and Wagner (1972) model adequately accommodates the full results of simple cue competition experiments in humans (e.g. Dickinson et al., 1984), while the Bush and Mosteller (1951) model cannot. We present simulations that demonstrate this assumption is wrong in at least some circumstances. The Rescorla-Wagner model, as usually applied, fits the full results of a simple forward cue-competition experiment no better than the Bush-Mosteller model. Additionally, we present a novel finding, where letting the associative strength of all cues start at an intermediate value (rather than zero), allows this modified model to provide …


Motivational Differences In Unipolar And Bipolar Depression, Manic Bipolar, Acute And Stable Phase Schizophrenia, Xinhua Yang, Jia Huang, Phillippa Harrision, Matthew E. Roser, Kai Tian, Dongfang Wang, Guangya Liu Mar 2021

Motivational Differences In Unipolar And Bipolar Depression, Manic Bipolar, Acute And Stable Phase Schizophrenia, Xinhua Yang, Jia Huang, Phillippa Harrision, Matthew E. Roser, Kai Tian, Dongfang Wang, Guangya Liu

School of Psychology

No abstract provided.


The Case Of Lionfish (Pterois Miles) In The Mediterranean Sea Demonstrates Limitations In Eu Legislation To Address Marine Biological Invasions, Periklis Kleitou, Jason M. Hall-Spencer, Ioannis Savva, Demetris Kletou, Margarita Hadjistylli, Ernesto Azzurro, Stelios Katsanevakis, Charalampos Antoniou, Louis Hadjioannou, Niki Chartosia, Maria Christou, Yiannis Christodoulides, Ioannis Giovos, Carlos Jimenez, Sonia Smeraldo, Siân E. Rees Mar 2021

The Case Of Lionfish (Pterois Miles) In The Mediterranean Sea Demonstrates Limitations In Eu Legislation To Address Marine Biological Invasions, Periklis Kleitou, Jason M. Hall-Spencer, Ioannis Savva, Demetris Kletou, Margarita Hadjistylli, Ernesto Azzurro, Stelios Katsanevakis, Charalampos Antoniou, Louis Hadjioannou, Niki Chartosia, Maria Christou, Yiannis Christodoulides, Ioannis Giovos, Carlos Jimenez, Sonia Smeraldo, Siân E. Rees

School of Biological and Marine Sciences

The European Regulation (EU) 1143/2014 on Invasive Alien Species entered into force in 2015, with the aim to fulfill regional and international biodiversity goals in a concerted manner. To date, the Regulation listed 66 Invasive Alien Species (IAS) that are subject to legal controls. Only one of these is marine. A recent lionfish (Pterois miles) invasion has been closely monitored in the Mediterranean and a detailed risk assessment was made about the profound impacts that this invasive fish is likely to have on the fisheries and biodiversity of the region. In 2016–21, lionfish rapidly became dominant predators along Eastern Mediterranean …