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An Investigation Of The Impacts Of A Dairy Industry Waste On River Water Quality And The Appropriateness Of Current Monitoring Approaches And Regulation, Rupert Goddard Jan 2022

An Investigation Of The Impacts Of A Dairy Industry Waste On River Water Quality And The Appropriateness Of Current Monitoring Approaches And Regulation, Rupert Goddard

School of Geography, Earth and Environmental Sciences Theses

Rupert Goddard AN INVESTIGATION OF THE IMPACTS OF A DAIRY INDUSTRY WASTE ON RIVER WATER QUALITY AND THE APPROPRIATENESS OF CURRENT MONITORING APPROACHES AND REGULATION. The modern dairy industry is a key contributor to global food security, with diverse production practices reflecting different geographic, economic and cultural contexts. Across the globe, the dairy industry has a significant contribution to global employment and wealth, health and land use. However, untreated or partially treated dairy waste entering a river system can be detrimental, increasing eutrophication, changing community structure or in the worst case scenario, causing death to organisms. Dairies are located near …


Developing A Virtual Approach To Determine If Ecosystem Service Provision Differs Between Scottish River Corridors With And Without Nature Designations, Victoria Keele Jan 2022

Developing A Virtual Approach To Determine If Ecosystem Service Provision Differs Between Scottish River Corridors With And Without Nature Designations, Victoria Keele

School of Geography, Earth and Environmental Sciences Theses

Humanity survives because we are graced with nature, or ‘ecosystem services’. In a time of turbulence caused by climate change and increasing population, there is debate surrounding the extent to which areas protected for biodiversity can deliver ecosystem services. Subsequently, the overarching aim of this PhD thesis is to determine if ecosystem service provision differs between Scottish river corridors with and without nature designations. To achieve the primary research aim, this thesis has a secondary aim of developing a methodology which can capture multiple riverine ecosystem services at the reach scale. Following an extensive review of the methods used to …


The Efficacy Of A Newly Developed Method Of Controlled Calcium Carbonate Introductions For Anthropogenic Acidification Mitigation In A Naturally Acidic Riverine Environment, Lauren Dawson Jan 2022

The Efficacy Of A Newly Developed Method Of Controlled Calcium Carbonate Introductions For Anthropogenic Acidification Mitigation In A Naturally Acidic Riverine Environment, Lauren Dawson

School of Geography, Earth and Environmental Sciences Theses

Historical anthropogenic acidification in the West Dart River, southwest England, represents a significant threat to surface water quality and aquatic ecology through flushing induced pH troughs and elevated bioavailable Aluminium (Al) levels. The West Dart River is failing to meet good ecological status established under the Water Framework Directive (2000/60/EC) (WFD) for pH (Upper West Dart, Cycle 2 classifications 2013-2019 = Moderate, physico-chemical quality elements 2013-2019 pH = Moderate). The aim of this study was to develop and test a method of controlled calcium carbonate (CaCO3) introductions, in order to preserve the naturally acidic riverine state and the biological communities …


The Developing Maternal-Infant Relationship: A Qualitative Longitudinal Study, Jane Peters Jan 2022

The Developing Maternal-Infant Relationship: A Qualitative Longitudinal Study, Jane Peters

School of Nursing and Midwifery Theses

Aim The study aimed to explore maternal perceptions and the use of knowledge relating to their infant’s mental health over time using qualitative longitudinal research. Background There has been a growing interest in infant mental health over recent years. Much of this interest is directed through the lens of infant determinism, through knowledge regarding neurological development resulting in biological determinism. Research and policy in this field are directed toward individual parenting behaviours, usually focused on the mother. Despite this, there is little attention given to maternal perspectives of infant mental health, indicating that a more innovative approach to methodology is …


Endogenous Retroviral Proteins As Potential Drug Targets For Merlin-Deficient Tumours, Bora Agit Jan 2022

Endogenous Retroviral Proteins As Potential Drug Targets For Merlin-Deficient Tumours, Bora Agit

Peninsula Medical School Theses

Merlin is a tumour suppressor, and its loss is the major cause of a hereditary disease Neurofibromatosis type 2 (NF2) characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. Current surgical treatments and radiotherapy for this group of tumours are not fully effective and there is an urgent need for new therapeutic options. Human endogenous retroviruses (HERVs) are retroviruses that have been incorporated into the human genome during evolution, now comprising 5% of it. The majority of HERVs are defective except for a few groups, including type K (HERV-K) which kept full-intact …


Novel Approaches To Assess Cellular Interactions And Their Role In The Pathology And Treatment Of Lymphoproliferative Disorders, Frances Hilary Rose Frend Jan 2022

Novel Approaches To Assess Cellular Interactions And Their Role In The Pathology And Treatment Of Lymphoproliferative Disorders, Frances Hilary Rose Frend

Other Faculty of Health Theses

Background: Migration and homing are essential to B-lymphocyte mediated immunity, and are driven by rapid, directed, and appropriate reorganisation of the actin cytoskeleton. Important observations have linked the cytoskeletal-rearrangements made by leukaemic B-lymphocytes of chronic lymphocytic leukaemia (CLL) to disease pathology. In particular, cytoskeletal alterations mediated by B-cell receptor (BCR) engagement or chemokine-binding are recognised to be central to the migration of CLL cells to lymphoid tissues, where they engage in the complex cellular and molecular interactions that underlie their survival, proliferation, and drug resistance. Further emphasising this importance, has been the observation that highly effective small molecule inhibitors that …


Nitrite And Insulin Lower The Oxygen Cost Of Atp Synthesis In Skeletal Muscle Cells By Pleiotropic Stimulation Of Glycolysis, Rosie Donnell Jan 2022

Nitrite And Insulin Lower The Oxygen Cost Of Atp Synthesis In Skeletal Muscle Cells By Pleiotropic Stimulation Of Glycolysis, Rosie Donnell

Other Faculty of Health Theses

Dietary nitrate lowers the oxygen cost of submaximal exercise, but precise mechanistic insight into how this occurs is lacking. Research suggests that dietary nitrate may render oxidative ATP synthesis more efficient, but evidence is inconclusive at present. This thesis aimed to establish how nitrite (a reduced form of nitrate) affects the bioenergetics of cultured skeletal muscle cells. Comparison between the acute effects of nitrite and insulin, a hormonal regulator of muscle function that increases mitochondrial efficiency, was explored to assess possible mechanistic overlap. Calculation of real-time intracellular ATP synthesis rates from simultaneous oxygen consumption and medium acidification measurements revealed the …


Prediction Of Cardiometabolic Risk In Children, Olubukola Ajala Jan 2022

Prediction Of Cardiometabolic Risk In Children, Olubukola Ajala

Other Faculty of Health Theses

Background: Three decades of clinical research have demonstrated that the risks of atherosclerotic cardiovascular disease (ACVD: coronary disease and ischaemic stroke), and the closely related type 2 diabetes (T2D) are established and influenced by events during childhood. This is at least partly because childhood obesity usually leads to adult adiposity; so, the currently high prevalence of adult cardiometabolic disease, means that obesity needs to be identified as early as possible, ideally in childhood. Screening for obesity largely relies on anthropometric measurements like body mass index (BMI), however this has many limitations including its inability to distinguish lean from fat mass. …


Architectural Design For Dementia: Exploring Alternate Contemporary Cultures Of Residential Care Design, Ricky Burke Jan 2022

Architectural Design For Dementia: Exploring Alternate Contemporary Cultures Of Residential Care Design, Ricky Burke

School of Art, Design and Architecture Theses

Architectural Design for Dementia: exploring alternate contemporary cultures of residential care design. The Alzheimer's Association (2018) projected the number of people living with a dementia diagnosis to surpass 2 million, reaching 1 in 37.5 of the population of the United Kingdom by 2051: up from 1 in 79 in 2015. This growth in rate and number coincides with an ageing population and a decline in the relative number of people able to care for the needs of people suffering difficulties associated with the symptoms of their diagnosis. The move to a residential care home is not only a viable but …


An Interdisciplinary Study Of An Aesthetic Particularism: The ‘Split Representation In The Art Of Asia And America’, Benjamin Pothier Jan 2022

An Interdisciplinary Study Of An Aesthetic Particularism: The ‘Split Representation In The Art Of Asia And America’, Benjamin Pothier

School of Art, Design and Architecture Theses

An interdisciplinary study of an aesthetic particularism: the ‘Split representation in the Art of Asia and America’. This thesis consists of an interdisciplinary research on an aesthetic particularism mentioned by anthropologist Claude Levi-Strauss as “The split representation in the Art of Asia and America” in his 1944 eponymous essay. Most researchers include in this group the Ainu and Jōmon People from Japan, tribes from the Amur Basin, Haida people from the Northern West Coast, Ancient China (Yangshao and Shang Dynasty), Māori People from New Zealand and Kadiweu people from Brazil. I conducted this inquiry through an online study of academic …


Molecular Control Of The Migratory Phase During Cutaneous Wound Healing, Chloe Elizabeth Bolton Jan 2022

Molecular Control Of The Migratory Phase During Cutaneous Wound Healing, Chloe Elizabeth Bolton

Other Faculty of Health Theses

Superficial cutaneous injuries occur on a huge scale across the globe; while most will resolve without intervention or any lasting damage, many will experience complications that arise through delayed healing or as a consequence of the skins protective barrier being breached. The migration of cutaneous cells across a wound site is a crucial factor in establishing permanent restoration of the skins integrity. This study provides insight into molecular events that facilitate the migratory ability of cutaneous cells during this phase of the healing process. Through subcellular analysis, molecular manipulation and various imaging techniques of in vivo and in vitro wound …


The Ecological And Social Effects Of Open Ocean Mussel Farming, Danielle Bridger Jan 2022

The Ecological And Social Effects Of Open Ocean Mussel Farming, Danielle Bridger

School of Biological and Marine Sciences Theses

Mussel aquaculture installations located in inshore waters have been shown to have a wide range of impacts on the surrounding environment and marine organisms, while also presenting a problem to other marine users. However, there is some evidence that moving these installations further offshore into the open ocean could mitigate these impacts. This thesis aimed to develop and pilot a robust monitoring programme that could be used to inform future management of aquaculture installations. A further aim was to assess the effects of mussel headlines at an open ocean long-line mussel farm, currently under development in Lyme Bay, southwest UK, …


The Neoliberal Game: An Critical Analysis Of Children's Non Competitive Grassroots Football, Grace Gallacher Jan 2022

The Neoliberal Game: An Critical Analysis Of Children's Non Competitive Grassroots Football, Grace Gallacher

School of Law, Humanities and Social Sciences Theses

This thesis explores the propensity for harms throughout children’s non-competitive football. Adopting ethnographic approaches this project follows a team of under 9’s non-competitive team in a SW FA league, it analyses their private social media page and conducted 18 semi-structured interviews with life-long players, parents, coaches and referees. It advances a critical criminology of sport by presenting an alternative framework to Elias and the Civilising process by using contemporary critical criminology, namely ultra-realism and deviant leisure. By using ultra-realism and deviant leisure this study examines the underlying systemic harm which comes from the neoliberal environment of sport, including children’s non-competitive …


Covid-19 Pandemic Impact On Psychotropic Prescribing For Adults With Intellectual Disability: An Observational Study In English Specialist Community Services, D Naqvi, B Perera, S Mitchell, R Sheehan, R Shankar Jan 2022

Covid-19 Pandemic Impact On Psychotropic Prescribing For Adults With Intellectual Disability: An Observational Study In English Specialist Community Services, D Naqvi, B Perera, S Mitchell, R Sheehan, R Shankar

Peninsula Medical School

Background Coronavirus disease 2019 (COVID-19) has had a disproportionate impact on people with intellectual disability (PwID). PwID are at higher risk of mental illness and receive psychotropic prescribing ‘off licence' also, to manage distress behaviour. The lockdown and reduction of multidisciplinary face-to-face appointments had an impact on care delivery, the recourse possibly being psychotropic prescribing. It is imperative to comprehend the influence the pandemic had on psychotropic prescribing patterns to enable future planning. Aims The aim was to understand the impact of the pandemic by comparing psychotropic prescribing patterns during the England lockdown with the prescribing patterns before lockdown in …


Organizational Perspectives On Outdoor Talking Therapy: Towards A Position Of ‘Environmental Safe Uncertainty’, Sam J. Cooley, Ceri R. Jones, Duncan Moss, Noelle Robertson Jan 2022

Organizational Perspectives On Outdoor Talking Therapy: Towards A Position Of ‘Environmental Safe Uncertainty’, Sam J. Cooley, Ceri R. Jones, Duncan Moss, Noelle Robertson

School of Psychology

No abstract provided.


What Matters Most To Adults With A Tracheostomy In Icu And The Implications For Clinical Practice: A Qualitative Systematic Review And Metasynthesis, Helen Newman, Gemma Clunie, Sarah Wallace, Christina Smith, Daniel Martin, Natalie Pattison Jan 2022

What Matters Most To Adults With A Tracheostomy In Icu And The Implications For Clinical Practice: A Qualitative Systematic Review And Metasynthesis, Helen Newman, Gemma Clunie, Sarah Wallace, Christina Smith, Daniel Martin, Natalie Pattison

Peninsula Medical School

Purpose Tracheostomy is a common surgical procedure in ICU. Whilst often life-saving, it can have important impacts on patients. Much of the literature on tracheostomy focuses on timing and technique of insertion, risk factors and complications. More knowledge of patient experience of tracheostomy in ICU is needed to support person-centred care. Materials and methods Qualitative systematic review and metasynthesis of the literature on adult experience of tracheostomy in ICU. Comprehensive search of four bibliographic databases and grey literature. Title and abstract screening and full text eligibility was completed independently by two reviewers. Metasynthesis was achieved using thematic synthesis, supported by …


Coral Reef Benthic Community Changes In The Anthropocene: Biogeographic Heterogeneity, Overlooked Configurations, And Methodology, Miriam Reverter, Stephanie B. Helber, Sven Rohde, Jm Goeij, Peter J. Schupp Jan 2022

Coral Reef Benthic Community Changes In The Anthropocene: Biogeographic Heterogeneity, Overlooked Configurations, And Methodology, Miriam Reverter, Stephanie B. Helber, Sven Rohde, Jm Goeij, Peter J. Schupp

School of Biological and Marine Sciences

Non-random community changes are becoming more frequent in many ecosystems. In coral reefs, changes towards communities dominated by other than hard corals are increasing in frequency, with severe impacts on ecosystem functioning and provision of ecosystem services. Although new research suggests that a variety of alternative communities (i.e. not dominated by hard corals) exist, knowledge on the global diversity and functioning of alternative coral reef benthic communities, especially those not dominated by algae, remains scattered. In this systematic review and meta-analysis of 523 articles, we analyse the different coral reef benthic community changes reported to date and discuss the advantages …


Loot Boxes And Problem Gambling: Investigating The “Gateway Hypothesis”, Stuart Gordon Spicer, Chris Fullwood, James Close, Laura Louise Nicklin, J Lloyd, H Lloyd Jan 2022

Loot Boxes And Problem Gambling: Investigating The “Gateway Hypothesis”, Stuart Gordon Spicer, Chris Fullwood, James Close, Laura Louise Nicklin, J Lloyd, H Lloyd

Peninsula Medical School

No abstract provided.


The Effects Of Owner And Domestic Cat (Felis Catus) Demographics On Cat Personality Traits, Laura E. Leech, Richard Preziosi, Rosica Stoycheva, Giovanni Quintavalle Pastorino Jan 2022

The Effects Of Owner And Domestic Cat (Felis Catus) Demographics On Cat Personality Traits, Laura E. Leech, Richard Preziosi, Rosica Stoycheva, Giovanni Quintavalle Pastorino

School of Biological and Marine Sciences

No abstract provided.


Ocean Shelf Exchange, Nw European Shelf Seas: Measurements, Estimates And Comparisons, John Huthnance, Jo Hopkins, Bee Berx, Andy Dale, Jason Holt, Philip Hosegood, Mark Inall, Sam Jones, Benjamin R. Loveday, Peter I. Miller, Jeff Polton, Marie Porter, C Springys Jan 2022

Ocean Shelf Exchange, Nw European Shelf Seas: Measurements, Estimates And Comparisons, John Huthnance, Jo Hopkins, Bee Berx, Andy Dale, Jason Holt, Philip Hosegood, Mark Inall, Sam Jones, Benjamin R. Loveday, Peter I. Miller, Jeff Polton, Marie Porter, C Springys

School of Biological and Marine Sciences

Transports across the continental shelf edge enhance shelf-sea production, remove atmospheric carbon and imply an active boundary to ocean circulation. We estimate relatively large overall transport across three contrasted sectors of north-west European shelf edge: the Celtic Sea south-west of Britain, the Malin-Hebrides shelf west of Scotland, the West Shetland shelf north of Scotland. The estimates derive from measurements in the project FASTNEt (Fluxes across sloping topography of the North East Atlantic): drifters, moored current meters, effective “diffusivity” from drifter dispersion and salinity surveys, other estimates of velocity variance contributing to exchange. Process contributions include transport by along-slope flow, internal …


Highest Densities Of Mountain Hares ( Lepus Timidus ) Associated With Ecologically Restored Bog But Not Grouse Moorland Management, Carlos P.E. Bedson, Philip M. Wheeler, Neil Reid, Wilson Edwin Harris, David Mallon, Simon Caporn, Richard Preziosi Jan 2022

Highest Densities Of Mountain Hares ( Lepus Timidus ) Associated With Ecologically Restored Bog But Not Grouse Moorland Management, Carlos P.E. Bedson, Philip M. Wheeler, Neil Reid, Wilson Edwin Harris, David Mallon, Simon Caporn, Richard Preziosi

School of Biological and Marine Sciences

No abstract provided.


Identifying Conservation Priorities For Gorgonian Forests In Italian Coastal Waters With Multiple Methods Including Citizen Science And Social Media Content Analysis, Arianna Liconti, Simon J. Pittman, Sian E. Rees, Nova Mieszkowska Jan 2022

Identifying Conservation Priorities For Gorgonian Forests In Italian Coastal Waters With Multiple Methods Including Citizen Science And Social Media Content Analysis, Arianna Liconti, Simon J. Pittman, Sian E. Rees, Nova Mieszkowska

School of Biological and Marine Sciences

No abstract provided.


Self-Management Intervention To Reduce Pulmonary Exacerbations By Supporting Treatment Adherence In Adults With Cystic Fibrosis: A Randomised Controlled Trial, Cfhealthhub Study Team, Martin J. Wildman, Alicia O’Cathain, Chin Maguire, Madelynne A. Arden, Marlene Hutchings, Judy Bradley, Stephen J. Walters, Pauline Whelan, John Ainsworth, Iain Buchan, Laura Mandefield, Laura Sutton, Paul Tappenden, Rachel A. Elliott, Zhe Hui Hoo, Sarah J. Drabble, Daniel Beever, H. Cantrill, J. Nicholl, S. Michie, S. Waterhouse, L. Robinson, A. Scott, S. Antrobus, E. Lumley, A. N. Biz, D. Hind, C. Orchard Jan 2022

Self-Management Intervention To Reduce Pulmonary Exacerbations By Supporting Treatment Adherence In Adults With Cystic Fibrosis: A Randomised Controlled Trial, Cfhealthhub Study Team, Martin J. Wildman, Alicia O’Cathain, Chin Maguire, Madelynne A. Arden, Marlene Hutchings, Judy Bradley, Stephen J. Walters, Pauline Whelan, John Ainsworth, Iain Buchan, Laura Mandefield, Laura Sutton, Paul Tappenden, Rachel A. Elliott, Zhe Hui Hoo, Sarah J. Drabble, Daniel Beever, H. Cantrill, J. Nicholl, S. Michie, S. Waterhouse, L. Robinson, A. Scott, S. Antrobus, E. Lumley, A. N. Biz, D. Hind, C. Orchard

Peninsula Medical School

Introduction Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent exacerbations, but objectively measured adherence is low. We investigated whether a multi-component (complex) self-management intervention to support adherence would reduce exacerbation rates over 12 months. Methods Between October 2017 and May 2018, adults with CF (aged ≥16 years; 19 UK centres) were randomised to the intervention (data-logging nebulisers, a digital platform and behavioural change sessions with trained clinical interventionists) or usual care (data-logging nebulisers). Outcomes included pulmonary exacerbations (primary outcome), objectively measured adherence, body mass index (BMI), lung function …


Consequences Of Thermal Plasticity For Hypoxic Performance In Coastal Amphipods, Michael Collins, Manuela Truebano, John I. Spicer Jan 2022

Consequences Of Thermal Plasticity For Hypoxic Performance In Coastal Amphipods, Michael Collins, Manuela Truebano, John I. Spicer

School of Biological and Marine Sciences

No abstract provided.


Ocean Connectedness And Consumer Responses To Single-Use Packaging, Sohvi Nuojua, Sabine Pahl, Richard Thompson Jan 2022

Ocean Connectedness And Consumer Responses To Single-Use Packaging, Sohvi Nuojua, Sabine Pahl, Richard Thompson

School of Biological and Marine Sciences

Single-use packaging items constitute a large proportion of the plastic litter found in the marine environment. Consumer decisions contribute to the accumulation of this pollution in the environment. Here we undertook two studies to assess consumer responses to different types of single-use packaging. Moreover, we introduce a new measure of ocean connectedness adapted from nature connectedness measures and investigate its association with consumer response. In Study 1, 60 UK undergraduate students completed a packaging rating task and a survey on ocean connectedness in a laboratory environment. In the rating task pictures of bottled drinks with unique combinations of packaging recyclability …


The Late Onset Of Emotional Distress In People With Progressive Multiple Sclerosis During The Covid-19 Pandemic: Longitudinal Findings From The Cogex Study, Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W. Motl, Maria Assunta Rocca, Brian M. Sandroff, Amber Salter Jan 2022

The Late Onset Of Emotional Distress In People With Progressive Multiple Sclerosis During The Covid-19 Pandemic: Longitudinal Findings From The Cogex Study, Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W. Motl, Maria Assunta Rocca, Brian M. Sandroff, Amber Salter

School of Health Professions

Objective: An earlier follow-up study from the CogEx rehabilitation trial showed little change in symptoms of depression, anxiety and psychological distress during the first COVID-19 lockdown compared to pre-pandemic measurements. Here we provide a second follow-up set of behavioral data on the CogEx sample. Methods: This was an ancillary, longitudinal follow-up study in CogEx, a randomized controlled trial of exercise and cognitive rehabilitation in people with progressive MS involving 11 centres in North America and Europe. Only individuals impaired on the Symbol Digit Modalities Test (SDMT) were included. Participants repeated the COVID Impact survey administered approximately a year later and …


At‐Risk Alcohol Users Have Disrupted Valence Discrimination During Reward Anticipation, Mica Komarnyckyj, Chris Retzler, Zhipeng Cao, Giorgio Ganis, Anna Murphy, Robert Whelan, Elsa Florence Fouragnan Jan 2022

At‐Risk Alcohol Users Have Disrupted Valence Discrimination During Reward Anticipation, Mica Komarnyckyj, Chris Retzler, Zhipeng Cao, Giorgio Ganis, Anna Murphy, Robert Whelan, Elsa Florence Fouragnan

School of Psychology

No abstract provided.


Hypertension Alters The Function And Expression Profile Of The Peptide Cotransporters Pept1 And Pept2 In The Rodent Renal Proximal Tubule, Othman A. Alghamdi, Nicola King, Nicholas M. Andronicos, Graham L. Jones, Belal Chami, Paul K. Witting, Pierre D.J. Moens Jan 2022

Hypertension Alters The Function And Expression Profile Of The Peptide Cotransporters Pept1 And Pept2 In The Rodent Renal Proximal Tubule, Othman A. Alghamdi, Nicola King, Nicholas M. Andronicos, Graham L. Jones, Belal Chami, Paul K. Witting, Pierre D.J. Moens

School of Biomedical Sciences

Hypertension is a major risk factor for kidney and cardiovascular disease. The treatment of hypertensive individuals by selected ACE inhibitors and certain di-and tripeptides halts the progression of renal deterioration and extends life-span. Renal reabsorption of these low molecular weight substrates are mediated by the PEPT1 and PEPT2 cotransporters. This study aims to investigate whether hypertension and ageing affects renal PEPT cotransporters at gene, protein expression and distribution as well as function in the superficial cortex and the outer medulla of the kidney. Membrane vesicles from the brush border (BBMV) and outer medulla (OMMV) were isolated from the kidneys of …


Synergistic Effects Of A Domestic (Thiacloprid Based) Neonicotinoid Pesticide And Nitrogen, Phosphorus And Potassium Fertiliser On Common Earthworms (Lumbricus Terrestris)., Tristan Holmes Jan 2022

Synergistic Effects Of A Domestic (Thiacloprid Based) Neonicotinoid Pesticide And Nitrogen, Phosphorus And Potassium Fertiliser On Common Earthworms (Lumbricus Terrestris)., Tristan Holmes

School of Biological and Marine Sciences Theses

Neonicotinoids are designed to target insect pests, but their extensive use and long persistence in soils mean that non-target soil organisms such as earthworms are likely to be chronically exposed to them. The common use of neonicotinoids in agricultural systems makes them highly likely to come into contact with other agro-chemicals that may give rise to synergistic effects. Chronic exposure of common earthworm (Lumbricus terrestris) to neonicotinoids in single or combined use with inorganic NPK fertiliser may pose problems that are not accounted for in most biological risk assessments under laboratory conditions. To assess the impacts of such chronic exposure …


Snake Community Ecology And Conservation In Cusuco National Park, Honduras, George Lonsdale Jan 2022

Snake Community Ecology And Conservation In Cusuco National Park, Honduras, George Lonsdale

School of Biological and Marine Sciences Theses

The Mesoamerican biodiversity hotspot is threatened with agriculture related deforestation and global climate change, both of which drive widespread changes in forest composition. As the forests change, so too does the community of animals they can support; of which many reptiles have evolved micro-niches specific to these forests. Studying how these anthropogenic pressures affect the assemblages of animals that can persist there, could be vital in understanding how biodiversity will be affected on a global scale. Cusuco National Park (CNP), Honduras, is one of the most important protected sites worldwide for herpetofauna biodiversity, due to having such a high diversity …