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Articles 1801 - 1830 of 6794
Full-Text Articles in Entire DC Network
Hepatic Transcriptomic And Histopathological Responses Of Common Carp, Cyprinus Carpio, To Copper And Microplastic Exposure, Seyyed Morteza Hoseini, Kave Khosraviani, Delavar F Hosseinpour, Mohammad Arghideh, Fatemeh Zavvar, Seyed Hossein Hoseinifar, Doan H Van, Erfan Zabihi, Miriam Reverter
Hepatic Transcriptomic And Histopathological Responses Of Common Carp, Cyprinus Carpio, To Copper And Microplastic Exposure, Seyyed Morteza Hoseini, Kave Khosraviani, Delavar F Hosseinpour, Mohammad Arghideh, Fatemeh Zavvar, Seyed Hossein Hoseinifar, Doan H Van, Erfan Zabihi, Miriam Reverter
School of Biological and Marine Sciences
The combined effects of copper and polyvinyl chloride (PVC) microparticles were investigated on the metal accumulation, histopathological biomarkers, and targeted transcriptomics in Cyprinus carpio liver. The fish were exposed to 0.25 mg/L copper and/or 0.5 mg/L PVC microparticles over a 14-d period. The results showed that hepatic copper accumulation is facilitated by the PVC microparticles presence in water. All treatments induced significant hepatic stress and inflammation; however, the transcriptional responses involving in detoxification pathways and apoptotic mechanisms were mixed and often down-regulated in the fish exposed to copper and/or PVC microparticles. Exposure to copper and/or PVC microparticles induced hypermeia, leukocyte …
Detection Of A Double-Stranded Mgmt Gene Using Electrochemically Reduced Graphene Oxide (Ergo) Electrodes Decorated With Aunps And Peptide Nucleic Acids (Pna), Mina Safarzadeh, Genhua Pan
Detection Of A Double-Stranded Mgmt Gene Using Electrochemically Reduced Graphene Oxide (Ergo) Electrodes Decorated With Aunps And Peptide Nucleic Acids (Pna), Mina Safarzadeh, Genhua Pan
School of Engineering, Computing and Mathematics
The ability to detect double-stranded DNA (dsDNA) as a biomarker without denaturing it to single-stranded DNA (ss-DNA) continues to be a major challenge. In this work, we report a sandwich biosensor for the detection of the ds-methylated MGMT gene, a potential biomarker for brain tumors and breast cancer. The purpose of this biosensor is to achieve simultaneous recognition of the gene sequence, as well as the presence of methylation. The biosensor is based on reduced graphene oxide (rGO) electrodes decorated with gold nanoparticles (AuNPs) and uses Peptide Nucleic Acid (PNA) that binds to the ds-MGMT gene. The reduction of GO …
Remote Sensing Of Tundra Ecosystems Using High Spectral Resolution Reflectance: Opportunities And Challenges, Peter R. Nelson, Andrew J. Maguire, Zoe Pierrat, Erica L. Orcutt, Dedi Yang, Shawn Serbin, Gerald V. Frost, Matthew J. Macander, Troy S. Magney, David R. Thompson, Jonathan A. Wang, Steven F. Oberbauer, Sergio Vargas Zesati, Scott J. Davidson, Howard E. Epstein, Steven Unger, Petya K.E. Campbell, Nimrod Carmon, M Velez‐Reyes, K. Fred Huemmrich
Remote Sensing Of Tundra Ecosystems Using High Spectral Resolution Reflectance: Opportunities And Challenges, Peter R. Nelson, Andrew J. Maguire, Zoe Pierrat, Erica L. Orcutt, Dedi Yang, Shawn Serbin, Gerald V. Frost, Matthew J. Macander, Troy S. Magney, David R. Thompson, Jonathan A. Wang, Steven F. Oberbauer, Sergio Vargas Zesati, Scott J. Davidson, Howard E. Epstein, Steven Unger, Petya K.E. Campbell, Nimrod Carmon, M Velez‐Reyes, K. Fred Huemmrich
School of Geography, Earth and Environmental Sciences
No abstract provided.
Hospital Sink Traps As A Potential Source Of The Emerging Multidrug-Resistant Pathogen Cupriavidus Pauculus: Characterization And Draft Genome Sequence Of Strain Mf1, James Butler, Sean D. Kelly, Katie J. Muddiman, Alexandros Besinis, Mathew Upton
Hospital Sink Traps As A Potential Source Of The Emerging Multidrug-Resistant Pathogen Cupriavidus Pauculus: Characterization And Draft Genome Sequence Of Strain Mf1, James Butler, Sean D. Kelly, Katie J. Muddiman, Alexandros Besinis, Mathew Upton
School of Biomedical Sciences
Introduction. Cupriavidus pauculus is historically found in soil and water but has more recently been reported to cause human infection and death. Hospital sink traps can serve as a niche for bacterial persistence and a platform for horizontal gene transfer, with evidence of dissemination of pathogens in hospital plumbing systems driving nosocomial infection. Gap Statement. This paper presents the first C. pauculus strain isolated from a hospital sink trap. There are only six genome assemblies available on NCBI for C. pauculus ; two of these are PacBio/Illumina hybrids. This paper presents the first ONT/Illumina hybrid assembly, with five contigs. The …
“I Love A Party With A Happy Atmosphere”; Notes On The Ontology Of Interpersonal Atmosphere, H Drayson
“I Love A Party With A Happy Atmosphere”; Notes On The Ontology Of Interpersonal Atmosphere, H Drayson
School of Art, Design and Architecture
No abstract provided.
Therapeutic Use Of Serious Games In Mental Health: Scoping Review, Alice Dewhirst, Richard Laugharne, Rohit Shankar
Therapeutic Use Of Serious Games In Mental Health: Scoping Review, Alice Dewhirst, Richard Laugharne, Rohit Shankar
Peninsula Medical School
Background There has been an increase in the development and application of serious games to support management of mental ill health, but their full impact is unclear. Aims Evaluation of the current evidence of acceptability and effectiveness of serious games in improving mental health disorders. Method A PRISMA-guided scoping review was conducted, using a predefined criteria and a relevant word combination on three databases: EMBASE, Medline and PsycINFO. Each included study was examined for game format, study type, number of participants, basic demographics, disorder targeted, recruitment, setting, control conditions, duration and follow-up, study attrition, primary outcomes and their results. Each …
Endotyping Asthma - Profiling The Metabolic Dimension?, Michael J. Wilde, Salman Siddiqui
Endotyping Asthma - Profiling The Metabolic Dimension?, Michael J. Wilde, Salman Siddiqui
School of Geography, Earth and Environmental Sciences
Asthma has long been recognised as a heterogeneous disease, and the notion of discrete endotypes of asthma has been prevalent for over a decade [1]. However, despite the success in identifying and targeting type-2 inflammation in asthma, the identification of tractable endotypes - has remained elusive; with not a single endotype defined with certainty. Here, Kelly et al, have reported putative novel asthma endotypes, defined using metabolomics (metabo-endotypes), in childhood asthma [2]. The metabolomics included unbiased multi-platform, metabolic profiling, using liquid chromatography and tandem mass spectrometry (LC-MS). The metabolic endotypes generated, were replicated against clinical outcomes in an independent cohort, …
Stepping Stones Towards Antarctica: Switch To Southern Spawning Grounds Explains An Abrupt Range Shift In Krill, Angus Atkinson, Simeon L. Hill, Christian S. Reiss, Evgeny A. Pakhomov, Gregory Beaugrand, Geraint A. Tarling, Guang Yang, Deborah K. Steinberg, Katrin Schmidt, Martin Edwards, Emilce Rombolá, Frances A. Perry
Stepping Stones Towards Antarctica: Switch To Southern Spawning Grounds Explains An Abrupt Range Shift In Krill, Angus Atkinson, Simeon L. Hill, Christian S. Reiss, Evgeny A. Pakhomov, Gregory Beaugrand, Geraint A. Tarling, Guang Yang, Deborah K. Steinberg, Katrin Schmidt, Martin Edwards, Emilce Rombolá, Frances A. Perry
School of Geography, Earth and Environmental Sciences
Poleward range shifts are a global-scale response to warming, but these vary greatly among taxa and are hard to predict for individual species, localized regions or over shorter (years to decadal) timescales. Moving poleward might be easier in the Arctic than in the Southern Ocean, where evidence for range shifts is sparse and contradictory. Here, we compiled a database of larval Antarctic krill, Euphausia superba and, together with an adult database, it showed how their range shift is out of step with the pace of warming. During a 70-year period of rapid warming (1920s–1990s), distribution centres of both larvae and …
Dentistry In A Multicultural Society: The Impact Of Animal-Based Products On Person-Centred Care, Kamran Ali, Pooja Gupta, Emma Turay, Lorna Burns, Zoe Brookes, Mahwish Raja
Dentistry In A Multicultural Society: The Impact Of Animal-Based Products On Person-Centred Care, Kamran Ali, Pooja Gupta, Emma Turay, Lorna Burns, Zoe Brookes, Mahwish Raja
Peninsula Dental School
Cultural competence of healthcare professionals requires a combination of awareness, knowledge and skills to provide healthcare services to culturally and lingually diverse populations. The aim of this paper is to raise awareness regarding animal-based constituents in dental products which may not be acceptable to patients from different cultural, spiritual, or religious backgrounds. Animal-based products are used widely in medicine and dentistry. However, patients and sometimes even dental professionals may not be aware of this. This paper identifies some common products used in clinical dentistry which are derived from animal-based sources and discusses the implications of their use in a multicultural …
Occurrence And Chemical Characteristics Of Microplastic Paint Flakes In The North Atlantic Ocean, Andrew Turner, Clare Ostle, Marianne Wootton
Occurrence And Chemical Characteristics Of Microplastic Paint Flakes In The North Atlantic Ocean, Andrew Turner, Clare Ostle, Marianne Wootton
School of Geography, Earth and Environmental Sciences
Non-fibrous microplastics sampled by the Continuous Plankton Recorder (CPR) Survey throughout the North Atlantic Ocean during 2018 have been recorded and a selection (n = 17, or 16.7%) physically and chemically characterised. The average abundance of non-fibrous particles captured by the plankton silks and detectable by microscopy was estimated to be around 0.01 m-3, with the highest concentrations evident in shelf seas of northwest Europe. Amongst the samples analysed, median size was 180 μm and, based on visible properties (e.g., brittleness, layering) and infra-red spectra, all but one were identified as flakes of paint. Semi-quantitative analysis by energy-dispersive X-ray fluorescence …
Thermal Safety Margins Of Plant Leaves Across Biomes Under A Heatwave, Nawatbhrist Kitudom, Sophie Fauset, Yingying Zhou, Zexin Fan, Murong Li, Mingjian He, Shubin Zhang, Kun Xu, Hua Lin
Thermal Safety Margins Of Plant Leaves Across Biomes Under A Heatwave, Nawatbhrist Kitudom, Sophie Fauset, Yingying Zhou, Zexin Fan, Murong Li, Mingjian He, Shubin Zhang, Kun Xu, Hua Lin
School of Geography, Earth and Environmental Sciences
Climate change has great impacts on forest ecosystems, especially with the increasing frequency of heatwaves. Thermal safety margin (TSM) calculated by the difference between body temperature and thermotolerance threshold is useful to predict thermal safety of organisms. It has been widely used for animals, whereas has rarely been reported for plants. Besides, most of the previous studies used only thermotolerance to estimate thermal safety or used thermotolerance and air temperature (Ta) to calculate TSM. However, leaf temperature (Tl) is the real "body" temperature of plant leaves. Tl decoupling from Ta might induce large error in TSM. Here, we investigated TSM …
The Bioaccumulation Testing Strategy For Nanomaterials: Correlations With Particle Properties And A Meta-Analysis Of In Vitro Fish Alternatives To In Vivo Fish Tests, R. D. Handy, N. J. Clark, D. Boyle, J. Vassallo, C. Green, F. Nasser, T. L. Botha, V. Wepener, Den Brink Nw Van, C. Svendsen
The Bioaccumulation Testing Strategy For Nanomaterials: Correlations With Particle Properties And A Meta-Analysis Of In Vitro Fish Alternatives To In Vivo Fish Tests, R. D. Handy, N. J. Clark, D. Boyle, J. Vassallo, C. Green, F. Nasser, T. L. Botha, V. Wepener, Den Brink Nw Van, C. Svendsen
School of Biological and Marine Sciences
This meta-analysis identifies linkages between the tiers in the bioaccumulation testing strategy.
Trajectory Of Serum Bilirubin Predicts Spontaneous Recovery In A Real-World Cohort Of Patients With Alcoholic Hepatitis, Richard Parker, Joaquin Cabezas, Jose Altamirano, Juan Pablo Arab, Meritxell Ventura-Cots, Ashish Sinha, Ashwin Dhanda, Marco Arrese, C. Anne Mccune, Ian A. Rowe, Bernd Schnabl, Phillipe Mathurin, Debbie Shawcross, Juan G. Abraldes, Michael R. Lucey, Guadalupe Garcia-Tsao, Elizabeth Verna, Robert S. Brown, Francisco Bosques-Padilla, Victor Vargas, Alexandre Louvet, Andrew P. Holt, Ramon Bataller
Trajectory Of Serum Bilirubin Predicts Spontaneous Recovery In A Real-World Cohort Of Patients With Alcoholic Hepatitis, Richard Parker, Joaquin Cabezas, Jose Altamirano, Juan Pablo Arab, Meritxell Ventura-Cots, Ashish Sinha, Ashwin Dhanda, Marco Arrese, C. Anne Mccune, Ian A. Rowe, Bernd Schnabl, Phillipe Mathurin, Debbie Shawcross, Juan G. Abraldes, Michael R. Lucey, Guadalupe Garcia-Tsao, Elizabeth Verna, Robert S. Brown, Francisco Bosques-Padilla, Victor Vargas, Alexandre Louvet, Andrew P. Holt, Ramon Bataller
Peninsula Medical School
No abstract provided.
Mangrove Diversity Is More Than Fringe Deep, Steven W.J. Canty, John Paul Kennedy, Graeme Fox, Kenan Matterson, Vanessa L. González, Mayra L. Núñez-Vallecillo, Richard F. Preziosi, Jennifer K. Rowntree
Mangrove Diversity Is More Than Fringe Deep, Steven W.J. Canty, John Paul Kennedy, Graeme Fox, Kenan Matterson, Vanessa L. González, Mayra L. Núñez-Vallecillo, Richard F. Preziosi, Jennifer K. Rowntree
School of Biological and Marine Sciences
AbstractMangroves form coastal tropical forests in the intertidal zone and are an important component of shoreline protection. In comparison to other tropical forests, mangrove stands are thought to have relatively low genetic diversity with population genetic structure gradually increasing with distance along a coastline. We conducted genetic analyses of mangrove forests across a range of spatial scales; within a 400 m2 parcel comprising 181 Rhizophora mangle (red mangrove) trees, and across four sites ranging from 6–115 km apart in Honduras. In total, we successfully genotyped 269 R. mangle trees, using a panel of 677 SNPs developed with 2b-RAD methodology. Within …
Essential Oils From Artemisia Herba Alba Asso., Maticaria Recutita L., And Dittrichia Viscosa L. (Asteraceae): A Promising Source Of Eco-Friendly Agents To Control Callosobruchus Maculatus Fab. Warehouse Pest, Allali Aimad, Mohammed Bourhia, Hadin Hana, Rezouki Sanae, Ahmad Mohammad Salamatullah, Walid Soufan, Hail Z. Rihan, Lahcen Ouahmane, El Abdali Youness, Eloutassi Noureddine, Fadli Mohamed
Essential Oils From Artemisia Herba Alba Asso., Maticaria Recutita L., And Dittrichia Viscosa L. (Asteraceae): A Promising Source Of Eco-Friendly Agents To Control Callosobruchus Maculatus Fab. Warehouse Pest, Allali Aimad, Mohammed Bourhia, Hadin Hana, Rezouki Sanae, Ahmad Mohammad Salamatullah, Walid Soufan, Hail Z. Rihan, Lahcen Ouahmane, El Abdali Youness, Eloutassi Noureddine, Fadli Mohamed
School of Biological and Marine Sciences
Callosobruchus maculatus (Fab.) (C. maculatus) is one of the major pests of legume seeds in storage causing significant damage, leading to food insecurity and low income for farmers. This work was planned to develop eco-friendly agents from essential oils of Artemisia herba alba Asso. (AEO), Maticaria Recutita L. (MEO), and Dittrichia Viscosa L. (DEO) to control C. maculatus. To achieve this goal, essential oils (EOs) were extracted by hydro-distillation using Clevenger apparatus before being characterized by GC-MS. EOs were used for testing purposes using three different tests, namely, inhalation toxicity, contact toxicity, and repellency tests. GC-MS analysis of EOs showed …
Decreased Diversity And Abundance Of Marine Invertebrates At Co2 Seeps In Warm-Temperate Japan, Jason M. Hall-Spencer, Giuseppe Belfiore, Morihiko Tomatsuri, Lucia Porzio, Ben P. Harvey, Sylvain Agostini, Koetsu Kon
Decreased Diversity And Abundance Of Marine Invertebrates At Co2 Seeps In Warm-Temperate Japan, Jason M. Hall-Spencer, Giuseppe Belfiore, Morihiko Tomatsuri, Lucia Porzio, Ben P. Harvey, Sylvain Agostini, Koetsu Kon
School of Biological and Marine Sciences
No abstract provided.
The Impact Of Led Lighting Spectra In A Plant Factory On The Growth, Physiological Traits And Essential Oil Content Of Lemon Balm (Melissa Officinalis), Hail Z. Rihan, Naofel Aljafer, Marwa Jbara, Lynn Mccallum, Sabine Lengger, Michael P. Fuller
The Impact Of Led Lighting Spectra In A Plant Factory On The Growth, Physiological Traits And Essential Oil Content Of Lemon Balm (Melissa Officinalis), Hail Z. Rihan, Naofel Aljafer, Marwa Jbara, Lynn Mccallum, Sabine Lengger, Michael P. Fuller
School of Biological and Marine Sciences
With the recent development of LED lighting systems for plant cultivation, the use of vertical farming under controlled conditions is attracting increased attention. This study investigated the impact of a number of LED light spectra (red, blue, green and white) on the growth, development and essential oil content of lemon balm (Melissa officinalis), a herb and pharmaceutical plant species used across the world. White light and red-rich light spectra gave the best outputs in terms of impact on the growth and yield. For blue-rich spectra, the development and yield was lower despite having a significant impact on the photosynthesis activity, …
Macromolecular Composition And Substrate Range Of Three Marine Fungi Across Major Cell Types, Seth Thomas, Sabine K. Lengger, Kimberley E. Bird, Ro Allen, Michael Cunliffe
Macromolecular Composition And Substrate Range Of Three Marine Fungi Across Major Cell Types, Seth Thomas, Sabine K. Lengger, Kimberley E. Bird, Ro Allen, Michael Cunliffe
School of Biological and Marine Sciences
Abstract Marine fungi exist as three major cell types: unicellular yeasts, filamentous hyphae and zoosporic early-diverging forms, such as the Chytridiomycota (chytrids). To begin to understand the ecological and biogeochemical influence of these cell types within the wider context of other plankton groups, cell size and macromolecular composition must be assessed across all three cell types. Using a mass–balance approach to culture, we describe quantitative differences in substrate uptake and subsequent macromolecular distribution in three model marine fungi: the yeast Metschnikowia zobellii, the filamentous Epicoccum nigrum and chytrid Rhizophydium littoreum. We compared these model cell types with select oleaginous phytoplankton …
Defining Routine Fatigue Care In Multiple Sclerosis In The United Kingdom: What Treatments Are Offered And Who Gets Them?, Federica Picariello, Jennifer Freeman, Rona Moss-Morris
Defining Routine Fatigue Care In Multiple Sclerosis In The United Kingdom: What Treatments Are Offered And Who Gets Them?, Federica Picariello, Jennifer Freeman, Rona Moss-Morris
School of Health Professions
Background Fatigue is common and disabling in Multiple Sclerosis (MS). A recent meta-analytic systematic review reported 113 trials of exercise and behavioural interventions for fatigue, yet patients consistently describe fatigue being under-treated. The extent of the research-to-practice gap is yet to be documented. Objective To describe what fatigue treatments people with MS (pwMS) in the United Kingdom (UK) have been offered. Methods A cross-sectional survey of pwMS on the UK MS Register (UKMSR). Data on fatigue treatments offered were collected using an online questionnaire developed with patient input and summarised using descriptive statistics. Sociodemographic, MS-related, and psychological factors associated with …
Developmental Impact Of Glutamate Transporter Overexpression On Dopaminergic Neuron Activity And Stereotypic Behavior, M Cohan, Jared M. Kopelman, Hannah Yueh, Hannah Yueh, Natasha Greene, Alexander Z. Harris, Peter D. Balsam, E. David Leonardo, Edgar R. Kramer, Jeremy Veenstra-Vanderweele, Susanne E. Ahmari
Developmental Impact Of Glutamate Transporter Overexpression On Dopaminergic Neuron Activity And Stereotypic Behavior, M Cohan, Jared M. Kopelman, Hannah Yueh, Hannah Yueh, Natasha Greene, Alexander Z. Harris, Peter D. Balsam, E. David Leonardo, Edgar R. Kramer, Jeremy Veenstra-Vanderweele, Susanne E. Ahmari
Peninsula Medical School
Obsessive-compulsive disorder (OCD) is a disabling condition that often begins in childhood. Genetic studies in OCD have pointed to SLC1A1, which encodes the neuronal glutamate transporter EAAT3, with evidence suggesting that increased expression contributes to risk. In mice, midbrain Slc1a1 expression supports repetitive behavior in response to dopaminergic agonists, aligning with neuroimaging and pharmacologic challenge studies that have implicated the dopaminergic system in OCD. These findings suggest that Slc1a1 may contribute to compulsive behavior through altered dopaminergic transmission; however, this theory has not been mechanistically tested. To examine the developmental impact of Slc1a1 overexpression on compulsive-like behaviors, we therefore generated …
Data From: A Marine Natural Capital Asset And Risk Register – Towards Securing The Benefits From Marine Systems And Linked Ecosystem Services, Sian Rees, Matthew Ashley, Tom Mullier
Data From: A Marine Natural Capital Asset And Risk Register – Towards Securing The Benefits From Marine Systems And Linked Ecosystem Services, Sian Rees, Matthew Ashley, Tom Mullier
Faculty of Science and Engineering Datasets
Data set and supporting information for: A Marine Natural Capital Asset and Risk Register – Towards securing the benefits from marine systems and linked ecosystem services. Citation Rees, S. et al. (2022). Data from: A Marine Natural Capital Asset and Risk Register – Towards securing the benefits from marine systems and linked ecosystem services. PEARL Research Repository http://hdl.handle.net/10026.1/18563
Potential Microplastic Release From The Maritime Industry: Abrasion Of Rope, I. E. Napper, Luka S. Wright, Aaron C. Barrett, F. N.F. Parker-Jurd, R. C. Thompson
Potential Microplastic Release From The Maritime Industry: Abrasion Of Rope, I. E. Napper, Luka S. Wright, Aaron C. Barrett, F. N.F. Parker-Jurd, R. C. Thompson
School of Biological and Marine Sciences
While land-based sources of plastic pollution have gained increasing attention in recent years, ocean-based sources have been less well studied. The aim of this study was to compare a variety of ropes (differing in age, wear surface and material) to quantify and characterise the production of microplastic during use. This was achieved by simulating, in laboratory and field experiments, rope hauling activity which is typically performed on board maritime vessels, such as fishing boats. Microplastic generation was quantified by collecting fragments that were released as a consequence of abrasion. Notably, we show that microplastic fragments generated from rope wear during …
Demonstrating The Translocation Of Nanoplastics Across The Fish Intestine Using Palladium-Doped Polystyrene In A Salmon Gut-Sac, Nathaniel J. Clark, Farhan R. Khan, Denise M. Mitrano, David Boyle, Richard C. Thompson
Demonstrating The Translocation Of Nanoplastics Across The Fish Intestine Using Palladium-Doped Polystyrene In A Salmon Gut-Sac, Nathaniel J. Clark, Farhan R. Khan, Denise M. Mitrano, David Boyle, Richard C. Thompson
School of Health Professions
No abstract provided.
Human Endogenous Retrovirus Type K Promotes Proliferation And Confers Sensitivity To Anti-Retroviral Drugs In Merlin-Negative Schwannoma And Meningioma., Emmanuel A. Maze, Bora Agit, Shona Reeves, David A. Hilton, David B. Parkinson, Liyam Laraba, Emanuela Ercolano, Kathreena M. Kurian, C. Oliver Hanemann, Robert D. Belshaw, Sylwia Ammoun
Human Endogenous Retrovirus Type K Promotes Proliferation And Confers Sensitivity To Anti-Retroviral Drugs In Merlin-Negative Schwannoma And Meningioma., Emmanuel A. Maze, Bora Agit, Shona Reeves, David A. Hilton, David B. Parkinson, Liyam Laraba, Emanuela Ercolano, Kathreena M. Kurian, C. Oliver Hanemann, Robert D. Belshaw, Sylwia Ammoun
Peninsula Medical School
Deficiency of the tumor suppressor Merlin causes development of schwannoma, meningioma, and ependymoma tumors, which can occur spontaneously or in the hereditary disease neurofibromatosis type 2 (NF2). Merlin mutations are also relevant in a variety of other tumors. Surgery and radiotherapy are current first-line treatments; however, tumors frequently recur with limited treatment options. Here, we use human Merlin-negative schwannoma and meningioma primary cells to investigate the involvement of the endogenous retrovirus HERV-K in tumor development. HERV-K proteins previously implicated in tumorigenesis were overexpressed in schwannoma and all meningioma grades, and disease-associated CRL4DCAF1 and YAP/TEAD pathways were implicated in this overexpression. …
Do Micronutrient And Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity During Pregnancy? A Scoping Review, G Rees, L Brough, Gm Orsatti, A Lodge, S Walker
Do Micronutrient And Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity During Pregnancy? A Scoping Review, G Rees, L Brough, Gm Orsatti, A Lodge, S Walker
School of Biomedical Sciences
Maternal dietary micronutrients and omega-3 fatty acids support development of the fetal and neonatal immune system. Whether supplementation is similarly beneficial for the mother during gestation has received limited attention. A scoping review of human trials was conducted looking for evidence of biochemical, genomic, and clinical effects of supplementation on the maternal immune system. The authors explored the literature on PubMed, Cochrane Library, and Web of Science databases from 2010 to the present day using PRISMA-ScR methodology. Full-length human trials in English were searched for using general terms and vitamin A, B12, C, D, and E; choline; iodine; iron; selenium; …
Total Water Column Analysis Shows The Importance Of A Single Species In Subsurface Chlorophyll Maximum Thin Layers In Stratified Waters, Michelle L. Barnett, Alan E.S. Kemp, W. Alex M. Nimmo-Smith, Duncan A. Purdie
Total Water Column Analysis Shows The Importance Of A Single Species In Subsurface Chlorophyll Maximum Thin Layers In Stratified Waters, Michelle L. Barnett, Alan E.S. Kemp, W. Alex M. Nimmo-Smith, Duncan A. Purdie
School of Biological and Marine Sciences
Marine phytoplankton form the base of marine food webs and are the driving force of the marine carbon cycle, so understanding the dynamics of their blooms is critical. While near-surface marine productivity (<10 m water depths) is extensively documented, that of the subsurface is less well characterised. Increasing evidence of the importance of subsurface chlorophyll maxima (SCM) and climatically driven increases in stratification of surface waters that promote SCM development call for improved sampling of the subsurface. To address this, we targeted the summer stratified waters of the Western English Channel, part of the NW European shelf seas, where SCM are commonly developed. In situ holography was applied to undertake the highest ever resolution, total water column, quantitative analysis of microplankton distribution, and demonstrated the importance of a SCM, co-located with the thermocline, dominated by a single species, the dinoflagellate Ceratium fusus. This species was dominant in the SCM over a wide area of the NW European shelf in the June/July 2015 study period and comprised up to 85% of the SCM biomass. Analysis of similarity and multivariate non-metric multidimensional scaling showed the phytoplankton community of the SCM to be statistically distinct from those of the surface and deep waters. Holography also revealed a fine scale layering of taxa at different levels within the SCM, likely reflecting ecological differences. Some taxa followed the peak abundance of C. fusus, while others reached maximum abundances immediately below or above the C. fusus maximum, suggesting the possible operation of exclusion mechanisms. Additionally, the detection of abundant aggregates located only within and beneath the SCM demonstrates the potential importance of this deep production for the export of carbon to the sea floor. Some predictions of phytoplankton productivity propose a shift to smaller cells in the more stratified oceans of the future resulting in declining production and export. Results presented here, however, contribute to a growing body of evidence that suggests, on the contrary, that key species among the larger celled/colonial, SCM-adapted diatoms and dinoflagellates may instead be selected in stratified conditions, driving increased production and export.
Determination Of Metallic Nanoparticles In Biological Samples By Single Particle Icp-Ms: A Systematic Review From Sample Collection To Analysis, Adam Laycock, Nathaniel J. Clark, Robert Clough, Rachel Smith, Richard D. Handy
Determination Of Metallic Nanoparticles In Biological Samples By Single Particle Icp-Ms: A Systematic Review From Sample Collection To Analysis, Adam Laycock, Nathaniel J. Clark, Robert Clough, Rachel Smith, Richard D. Handy
School of Health Professions
A systematic review of the use of single particle ICP-MS to analyse engineered nanomaterials in biological samples has highlighted that efforts have focused on a select few compositions and there is a lack of information for some important tissues.
Non‐Lethal Sampling For The Stable Isotope Analysis Of The Critically Endangered European Eel Anguilla Anguilla : How Fin And Mucus Compare To Dorsal Muscle, Rm Boardman, Ac Pinder, At Piper, Catherine Gutmann Roberts, Rm Wright, Jr Britton
Non‐Lethal Sampling For The Stable Isotope Analysis Of The Critically Endangered European Eel Anguilla Anguilla : How Fin And Mucus Compare To Dorsal Muscle, Rm Boardman, Ac Pinder, At Piper, Catherine Gutmann Roberts, Rm Wright, Jr Britton
School of Biological and Marine Sciences
Ecological studies on the critically endangered European eel Anguilla anguilla often incorporate stable isotope analysis that typically uses dorsal muscle sampled from euthanised eels. To minimise the lethal sampling of imperilled populations, fin tissue and/or epidermal mucus can provide non-lethal alternatives to muscle. The results here indicate that δ13 C and δ15 N values of both eel fin and mucus are not significantly different from those of muscle and can be applied directly in comparative SI studies.
Conflicting Interests And Growing Importance Of Non‐Indigenous Species In Commercial And Recreational Fisheries Of The Mediterranean Sea, Periklis Kleitou, Dimitrios K. Moutopoulos, Ioannis Giovos, Demetris Kletou, Ioannis Savva, Leda L. Cai, Jm Hall‐Spencer, Anastasia Charitou, Maria Elia, George Katselis, Siân Rees
Conflicting Interests And Growing Importance Of Non‐Indigenous Species In Commercial And Recreational Fisheries Of The Mediterranean Sea, Periklis Kleitou, Dimitrios K. Moutopoulos, Ioannis Giovos, Demetris Kletou, Ioannis Savva, Leda L. Cai, Jm Hall‐Spencer, Anastasia Charitou, Maria Elia, George Katselis, Siân Rees
School of Biological and Marine Sciences
No abstract provided.
Allometric Relationships Of Ecologically Important Antarctic And Arctic Zooplankton And Fish Species, Fokje L. Schaafsma, Carmen L. David, Doreen Kohlbach, Julia Ehrlich, Giulia Castellani, Benjamin A. Lange, Martina Vortkamp, André Meijboom, Anna Fortuna-Wünsch, Antonia Immerz, Hannelore Cantzler, Apasiri Klasmeier, Nadezhda Zakharova, Katrin Schmidt, Anton P. Van De Putte, Jan Andries Van Franeker, Hauke Flores
Allometric Relationships Of Ecologically Important Antarctic And Arctic Zooplankton And Fish Species, Fokje L. Schaafsma, Carmen L. David, Doreen Kohlbach, Julia Ehrlich, Giulia Castellani, Benjamin A. Lange, Martina Vortkamp, André Meijboom, Anna Fortuna-Wünsch, Antonia Immerz, Hannelore Cantzler, Apasiri Klasmeier, Nadezhda Zakharova, Katrin Schmidt, Anton P. Van De Putte, Jan Andries Van Franeker, Hauke Flores
School of Geography, Earth and Environmental Sciences
Allometric relationships between body properties of animals are useful for a wide variety of purposes, such as estimation of biomass, growth, population structure, bioenergetic modelling and carbon flux studies. This study summarizes allometric relationships of zooplankton and nekton species that play major roles in polar marine food webs. Measurements were performed on 639 individuals of 15 species sampled during three expeditions in the Southern Ocean (winter and summer) and 2374 individuals of 14 species sampled during three expeditions in the Arctic Ocean (spring and summer). The information provided by this study fills current knowledge gaps on relationships between length and …