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Articles 301 - 330 of 10967
Full-Text Articles in Entire DC Network
The Effectiveness Of Digital Therapeutics Intervention In Oral Anticoagulation Management: A Systematic Review And Meta-Analysis, Jiayue Guo, Lili You, Lu Liu, Xitong Jiao, Debasish Kar, Jitendra Jonnagaddala
The Effectiveness Of Digital Therapeutics Intervention In Oral Anticoagulation Management: A Systematic Review And Meta-Analysis, Jiayue Guo, Lili You, Lu Liu, Xitong Jiao, Debasish Kar, Jitendra Jonnagaddala
Peninsula Medical School
Objective: To summarize the key intervention characteristics and evaluate the effectivenessand safety of digital therapeutics (DTx) in patients receiving oral anticoagulation, witheffectiveness evaluated using time in therapeutic range (TTR), thromboembolic events (TEE),and mortality, and safety evaluated based on bleeding events.Patients and Methods: We searched PubMed, Embase, Web of Science, and the CochraneLibrary from inception to June 20, 2025, and identified ten randomized controlled trialsinvolving 7,237 patients. The criteria required studies to assess software-based DTxsupporting anticoagulation management and report effectiveness or safety outcomes. Studyquality was evaluated using the Grading of Recommendations, Assessment, Development,and Evaluation (GRADE) framework, and random-effects models were applied.Results: …
Patient And Practitioner Workshops For An Intellectual Disabilities And Epilepsy Neuropsychiatric Genetic Research Database Register: Ethical Dilemmas For Study Design, Rohit Shankar, Jon Allard, Dannielle Bilkey, Brendan Mclean, Pamela Bowman, Chloe Staples, Lance Watkins, Anna Simpson, Elizabeth Boardman, Sarah Mitchell, Sarah Lennard
Patient And Practitioner Workshops For An Intellectual Disabilities And Epilepsy Neuropsychiatric Genetic Research Database Register: Ethical Dilemmas For Study Design, Rohit Shankar, Jon Allard, Dannielle Bilkey, Brendan Mclean, Pamela Bowman, Chloe Staples, Lance Watkins, Anna Simpson, Elizabeth Boardman, Sarah Mitchell, Sarah Lennard
Peninsula Medical School
BackgroundThere is a need for more research studies focussed on People with ID (PwID) and Epilepsy and for the design of these studies to be shaped by this complex and vulnerable population and those who care for and support them.AimsTo develop understanding as to how a future NHS genetic research database register for PwID and Epilepsy should be conducted in a way which is inclusive, suitable and appropriate for them, their carers and the NHS settings where the research would be undertaken.MethodsThree workshops were completed with 17 formal participants: (1) PwID and Epilepsy (n2); (2) carers of PwID and Epilepsy …
Involving Parents In Prevention: A Case Example Of Research And Intervention Development To Improve Financial Well-Being Support, Nick Axford, Gisella Hanley, Rebecca Summers, Kristin Liabo, Amy Bond, Eleanor Bryant, Georgia Smith, Rachel Silcock, Vashti Berry
Involving Parents In Prevention: A Case Example Of Research And Intervention Development To Improve Financial Well-Being Support, Nick Axford, Gisella Hanley, Rebecca Summers, Kristin Liabo, Amy Bond, Eleanor Bryant, Georgia Smith, Rachel Silcock, Vashti Berry
Peninsula Medical School
The adverse effects on parent and child outcomes of poverty and stressors associated with low income are well established. With notable exceptions, however, the potential role of frontline services in improving family financial well-being is underexplored. This article outlines how patient and public involvement (PPI) was initiated early on in research on financial well-being support (FWbS). It illustrates how research can build on and integrate what parents say about services and how to research them. The involvement work was undertaken in one city in part to inform the adaptation of an income maximisation service to be delivered in local children’s …
Microplastics, Nanoplastics And Liver Disease: An Emerging Health Concern?, Shilpa Chokshi, Ashwin Dhanda, Matthew E. Cramp, Richard Thompson
Microplastics, Nanoplastics And Liver Disease: An Emerging Health Concern?, Shilpa Chokshi, Ashwin Dhanda, Matthew E. Cramp, Richard Thompson
Peninsula Medical School
Human liver tissue has been found to contain microplastics and nanoplastics (MNPs), with evidence that hepatic MNP accumulation has markedly increased over the past 10 years, prompting critical questions regarding their potential causal role in liver disease. In cell-based and murine models, MNP exposure can trigger oxidative stress, fibrogenesis and inflammation, pathological features that resemble those of advanced liver disease, suggesting shared mechanistic pathways. Furthermore, the capacity for MNPs to act as vectors for microbial pathogens, antimicrobial resistance, endocrine-disrupting chemicals and carcinogenic additives might have important implications for liver pathology. This Perspective examines emerging evidence on the consequences of MNPs …
Designing A Mobile App For Post Traumatic Stress Disorder: Insights From Lived Experience And Clinical Practice, Rohit Shankar, Richard Laugharne, Michael Loizou, Marius Varga, Sivia Lin, Bojana Daw Srdanovic, Roger Farrell
Designing A Mobile App For Post Traumatic Stress Disorder: Insights From Lived Experience And Clinical Practice, Rohit Shankar, Richard Laugharne, Michael Loizou, Marius Varga, Sivia Lin, Bojana Daw Srdanovic, Roger Farrell
Peninsula Medical School
Post-traumatic stress disorder (PTSD) is a disabling anxiety disorder precipitated by severe trauma. Many people with this condition have little access to clinical interventions, especially in low-middle-income countries. For the development of any digital health intervention, it is vital to know the opinions of PLE and clinicians to guide the developers. We conducted two focus groups, one with clinicians (n = 5) and one with people with lived experience (PLE) (n = 11), to gain knowledge of their views on the development of a PTSD App. Transcripts of both focus groups were coded and thematically analysed. The key themes that …
Safe Practice Guidance And Brief Manual Revised, Becky Stancer, Rudi Dallos
Safe Practice Guidance And Brief Manual Revised, Becky Stancer, Rudi Dallos
School of Law, Humanities and Social Sciences
Revised and updated practice manual for SAFE2 website
Fault Tolerant Adaptive Control Under Actuator Saturation For Robot Manipulators, D. J. López-Araujo, N. Alvarez-Jarquin, P. Borja, A. T. Becker
Fault Tolerant Adaptive Control Under Actuator Saturation For Robot Manipulators, D. J. López-Araujo, N. Alvarez-Jarquin, P. Borja, A. T. Becker
School of Engineering, Computing and Mathematics
In practice, actuators inherently have natural limitations that are often overlooked by theoretical control strategies, such as bounded output and discrepancies between calculated and actual responses. Consequently, reliable control techniques must be employed to ensure safe and dependable operation. We propose an adaptive control law for global regulation in the case of partial loss of effectiveness due to input faults. The proposed control strategy maintains the system at the desired configuration while accounting for the physical limitations of the actuators. Additionally, it is suitable for dealing with unknown parameters in the vector of gravitational forces, making it robust to these …
Angle-Based Formation Stabilization And Maneuvers In Port-Hamiltonian Form With Bearing And Velocity Measurements, Ningbo Li, Pablo Borja, Arjan Van Der Schaft, Jacquelien M.A. Scherpen
Angle-Based Formation Stabilization And Maneuvers In Port-Hamiltonian Form With Bearing And Velocity Measurements, Ningbo Li, Pablo Borja, Arjan Van Der Schaft, Jacquelien M.A. Scherpen
School of Engineering, Computing and Mathematics
This paper proposes a port-Hamiltonian approach for angle-based formation stabilization and maneuvers using bearing and velocity measurements with an underlying triangulated Laman graph. The corresponding port-Hamiltonian controller is designed using virtual couplings on the errors of angle constraints in angle space. Then, the angle constraints and agent actuators are mapped by the constraint Jacobian, which can be applied to other formation constraints. In addition, to avoid unavailable distance terms in the control law, an estimator is designed based on port-Hamiltonian theory and the property that energy is coordinate-free for different sensor modalities using bearing and velocity measurements, which permits our …
Usable Authentication: Are We There Yet?, Nathan Clarke, Steven Furnell
Usable Authentication: Are We There Yet?, Nathan Clarke, Steven Furnell
School of Engineering, Computing and Mathematics
With technology increasingly embedded in everyday life, the demand for secure and usable authentication methods has never been greater. Traditional password-based systems continue to dominate, despite well-known usability and security challenges. This paper explores the evolution of user authentication technologies, from secret knowledge and tokens to biometrics and emerging approaches such as Passkeys. It critically evaluates the extent to which usability has been achieved, identifying both successes—such as biometrics integrated into smartphones—and persistent issues, including inconsistent guidance, ecosystem dependence, and accessibility barriers. Drawing on academic and commercial developments, the discussion highlights the growing burden on users who must authenticate across …
From Predictions To Explanations: Explainable Ai For Autism Diagnosis And Identification Of Critical Brain Regions: 18th International Joint Conference, Biostec 2025, Kush Gupta, Amir Aly, Emmanuel Ifeachor, Rohit Shankar
From Predictions To Explanations: Explainable Ai For Autism Diagnosis And Identification Of Critical Brain Regions: 18th International Joint Conference, Biostec 2025, Kush Gupta, Amir Aly, Emmanuel Ifeachor, Rohit Shankar
School of Engineering, Computing and Mathematics
Autism spectrum disorder (ASD) is a neurodevelopmentalcondition characterized by atypical brain maturation. However, the adaptationof transfer learning paradigms in machine learning for ASD researchremains notably limited. In this study, we propose a computeraideddiagnostic framework with two modules. This chapter presents atwo-module framework combining deep learning and explainable AI forASD diagnosis. The first module leverages a deep learning model finetunedthrough cross-domain transfer learning for ASD classification. Thesecond module focuses on interpreting the model’s decisions and identifyingcritical brain regions. To achieve this, we employed three explainableAI (XAI) techniques: saliency mapping, Gradient-weighted Class ActivationMapping, and SHapley Additive exPlanations (SHAP) analysis.This framework demonstrates that …
Job Satisfaction, Burnout, And Intent To Stay In Neonatal Nursing In England And Wales: A Cross-Sectional Survey Study, Kathy Chant, Yoko Nishimura, Aviva Petrie, Jos M. Latour, Nicola Booth, Kelly Crofts, Lisa Viola, Katie Gallagher
Job Satisfaction, Burnout, And Intent To Stay In Neonatal Nursing In England And Wales: A Cross-Sectional Survey Study, Kathy Chant, Yoko Nishimura, Aviva Petrie, Jos M. Latour, Nicola Booth, Kelly Crofts, Lisa Viola, Katie Gallagher
School of Nursing and Midwifery
Objective: To explore job satisfaction, burnout and intent to stay in neonatal nurses in England and Wales. Methods: A cross-sectional online survey study using the McCloskey Mueller Satisfaction Scale (MMSS) to explore job satisfaction, the Copenhagen Burnout Inventory (CBI) to explore burnout and the Nurse Retention Index (NRI) to measure intent to stay. All neonatal nurses working in England and Wales were eligible to take part. Data were collected between February and September 2024. Results: A total of 1590 neonatal nurses completed the survey. Job satisfaction was neutral. Moderate work burnout was reported, with statistically significant differences in mean score …
Making The Implicit Explicit: Leadership In Primary Care Dental Practice, Sally Hanks, Debby R.E. Cotton
Making The Implicit Explicit: Leadership In Primary Care Dental Practice, Sally Hanks, Debby R.E. Cotton
Peninsula Dental School
Objectives: This paper reports on research aimed at understanding leadership activities in primary care dental practice, an under-explored area within the extant literature. Methods: The research employed a qualitative, exploratory paradigm, using Video Reflexive Ethnography (VRE) and Activity Theory (AT) to capture the lived experiences of seven participating dentists. Results: The research outlines the ways in which dentists demonstrate leadership skills in their daily work, identifying three interacting activity systems that define leadership in this setting: Patient Care (PC), Running the Surgery (RS), and Running the Practice (RP). Findings emphasise that leadership is directly related to patient care and is …
Leveraging Natural Language Processing Methods For Next Generation Customer Service In Telecommunications Industry, Hesham Abdelmotaleb
Leveraging Natural Language Processing Methods For Next Generation Customer Service In Telecommunications Industry, Hesham Abdelmotaleb
School of Engineering, Computing and Mathematics Theses
This research explores application of Natural Language Processing (NLP) methods to better understand and improve customer service feedback in telecom industry. We collect novel reallife datasets of customer reviews and social media comments within British telecommunication industry over one year. Then, we apply three main modelling approaches. First, we study topic modelling for short text: we propose a new evaluation metric for GSDMM model and demonstrate that our metric helps to choose meaningful topics when texts are very brief. Second, we perform an extensive comparative study of word embedding models for text classification: we test nine word embedding and feature …
A General Tool To Assist With On Orbit Manufacturing, Richard Arundal
A General Tool To Assist With On Orbit Manufacturing, Richard Arundal
School of Engineering, Computing and Mathematics Theses
On-Orbit Manufacturing (OOM) presents a transformative paradigm in space mission design, enabling the in-situ production of components, tools, and large-scale structures beyond terrestrial constraints. This dissertation investigates the feasibility of OOM missions by developing a modular, iterative algorithm to support early-stage mission design and scenario analysis. The central hypothesis is that such an algorithm can be parameterised to evaluate a wide spectrum of manufacturing cases in space, ranging from small utility items to large structural systems.The research pursues four core objectives: assessing the terrestrial manufacturing lifecycle and its applicability in the space environment; identifying candidate manufacturing techniques suitable for orbital …
Coupled Thermo-Structural Analysis Of Steel Reinforced Geopolymer Concrete Structural Members, Bin Zhang
Coupled Thermo-Structural Analysis Of Steel Reinforced Geopolymer Concrete Structural Members, Bin Zhang
School of Engineering, Computing and Mathematics Theses
This thesis investigates the coupled thermal, flexural and steel–concrete bond response of steel-reinforced geopolymer concrete (GPC) and ordinary Portland cement concrete (OPCC) beam cross-sections subjected to one-sided standard fire exposure. A sequential analytical framework is developed to link transient heat-transfer analysis, temperature-dependent sectional flexural analysis, and temperature-dependent bond and flexural–bond coupling assessment.The thermal analysis is performed using a one-dimensional transient heat-conduction model implemented in MATLAB PDEPE. Separate temperature-dependent density, specific-heat and thermal-conductivity relationships are adopted for OPCC and GPC. A dedicated OPCC model of the B1 validation specimen is assessed against 13 matched experimental reinforcement-temperature measurements, giving R^2=0.9542 and an …
Life Cycle Assessment Of Marine Composite Recreational Craft Manufacturing And Operations, Badr Moutik
Life Cycle Assessment Of Marine Composite Recreational Craft Manufacturing And Operations, Badr Moutik
School of Engineering, Computing and Mathematics Theses
Marine composite recreational craft are growing in number. Sectoral roadmaps for sustainable development are increasing pressure to demonstrate life cycle environmental performance. Life cycle assessment (LCA) has been identified as a key strategic decision support tool. However, current practice is undermined by sparse, non-representative data and methodological inconsistencies. These weaknesses increase the risk of biased or misleading interpretation, constrain wider uptake of LCA, and limit the sector’s ability to respond credibly to tightening environmental sustainability expectations. This thesis assesses the cradle-to-grave environmental impacts of a market-representative glass-fibre reinforced plastic (GRP) motor yacht across 16 impact categories. The research builds on …
The Effects Of Altered Partial Pressures Of Gas On Cognitive And Neural Function, Daniel Graham
The Effects Of Altered Partial Pressures Of Gas On Cognitive And Neural Function, Daniel Graham
School of Psychology Theses
Oxygen is central to neural function, yet the precise mechanisms and effects by which varying oxygen levels, whether through Hypoxia, Hyperoxia, or Hyperbaric Oxygen Therapy (HBOT), shape cognition and brain activity remain incomplete. This thesis adopts a novel, multi-modal framework that integrates normobaric gas manipulations, cognitive testing, Transcranial Magnetic Stimulation (TMS), Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), and HBOT to examine how gas and pressure variability influences cognitive, motor, and neural processes. Chapter 3 presents the findings of a preliminary experiment investigating normobaric oxygen manipulations on cognition. Standardised cognitive assessments revealed domain-general impairments (i.e. memory and executive function) under …
A Psychosocial And Psychometric Exploration Of Hikikomori In The Uk, Gregory Gorman
A Psychosocial And Psychometric Exploration Of Hikikomori In The Uk, Gregory Gorman
School of Psychology Theses
Hikikomori - originally identified in Japan as a severe form of social withdrawal - has evolved into a global phenomenon mirroring broader transformations in labour, technology, and identity. Once deemed a culture-bound syndrome, it is increasingly understood as a “society-bound” expression of psychosocial strain, existential unease, and retreat from normative life scripts. This thesis advances understanding of hikikomori by developing and validating psychometric tools, identifying subtypes of withdrawal, and situating the phenomenon within wider socio-cultural, digital, and philosophical frameworks.Empirical chapters detail the development of two novel tools: the Hikikomori Risk Inventory-13 (HRI-13) and the expanded Hikikomori Syndrome Behaviour Scale (HSBS). …
‘Male Victims Of ‘Honour Crimes’: A Critical Examination Of The Concepts Of ‘Honour’ And The Wider Debates Surrounding ‘So-Called Honour-Based Violence’ And ‘Hate Crime’, Narissa Maclennan-Matthews
‘Male Victims Of ‘Honour Crimes’: A Critical Examination Of The Concepts Of ‘Honour’ And The Wider Debates Surrounding ‘So-Called Honour-Based Violence’ And ‘Hate Crime’, Narissa Maclennan-Matthews
School of Law, Humanities and Social Sciences Theses
This thesis critically interrogates the experiences of male victims of ‘so-called honour-based violence and abuse’ (SCHBVA) through an intersectional criminological framework. It draws primarily on Barbara Perry’s theories of ‘Doing Difference’ (2001; 2003) and the ‘in terrorem effects’ of hate crime (Perry & Alvi, 2012), alongside insights from Structural Criminology (Hartjen, 1978; Kramer, 1985) and Humanistic Criminology (Hagan, 1986). Drawing on semi-structured interviews with male survivors and criminal justice professionals, and employing thematic and case study analysis, the study examines how violence is produced and legitimised across intersecting axes of gender, sexuality, ethnicity, and religion.Building on Perry’s conceptualisation of ‘Doing …
Plymouth Naval Command: A Study Of Interservice Co-Operation During The Second World War, James Bartle
Plymouth Naval Command: A Study Of Interservice Co-Operation During The Second World War, James Bartle
School of Law, Humanities and Social Sciences Theses
This thesis examines the role of ideas of interservice co-operation in the operations of Plymouth Naval Command during the Second World War. The importance of naval shore commands has been a significant omission from studies of the war at sea. Located at strategic points around Britain, they were vital in controlling the flow of convoy shipping, while also co-ordinating attacks against enemy surface forces and submarines. This was achieved using a marriage of air and sea power between the Royal Navy and Coastal Command, a relationship that was developed during the 1920s and 1930s. Using Plymouth Command as an entry …
Staphylococcus Aureus Strain Heterogeneity Modulates Virulence Traits Associated To Dual-Species Biofilms With Candida Albicans, Laure Nicolas Annick Ries, Beata Adrienn Brezniczky, Binduja Srelatha Pradeep, Esther Olabamiji, Lee Hutt, Glenn M. Harper, Alexander Strachan, Gyorgy Fejer
Staphylococcus Aureus Strain Heterogeneity Modulates Virulence Traits Associated To Dual-Species Biofilms With Candida Albicans, Laure Nicolas Annick Ries, Beata Adrienn Brezniczky, Binduja Srelatha Pradeep, Esther Olabamiji, Lee Hutt, Glenn M. Harper, Alexander Strachan, Gyorgy Fejer
School of Biomedical Sciences
Staphylococcus aureus is a commensal Gram-positive bacterium and opportunistic pathogen that exhibits substantial variation in antimicrobial resistance and virulence traits. S. aureus is frequently co-isolated with the fungus Candida albicans, and together they represent the most common microorganisms recovered from biofilm-associated infections originating from both biotic and abiotic surfaces. Despite this clinical relevance, the impact of bacterial intra-species variation on interkingdom interactions remains poorly understood. This study therefore investigated how S. aureus strain heterogeneity influences C. albicans within dual-species biofilms. The majority of the 60 S. aureus strains tested suppressed fungal growth in a contact-dependent manner across different nutrient conditions …
Ethnic Diversity In Uk Bioscience: Structural Biases And Recommendations For Action, Yusra Siddiqui, Prachi Stafford, Emmanuel Adukwu, Nicholas Freestone, Tina Lovleen Joshi, Emma Yhnell, Katharine Hubbard
Ethnic Diversity In Uk Bioscience: Structural Biases And Recommendations For Action, Yusra Siddiqui, Prachi Stafford, Emmanuel Adukwu, Nicholas Freestone, Tina Lovleen Joshi, Emma Yhnell, Katharine Hubbard
Peninsula Dental School
Scientific research is more innovative and impactful when scientists are drawn from diverse backgrounds. However, the scientific community does not reflect the demographics of wider society. Global Majority communities remain underrepresented within science, particularly within senior leadership roles. Here we explore ethnic diversity within UK academic biosciences, using publicly available staff and student demographic data from the UK Higher Education Statistics Authority. We use the Simpson index as a quantitative measure of diversity within the biosciences and construct linear mixed effect models to identify significant predictors of both student and staff ethnic diversity. For staff, there were significant negative effects …
Simulation-Based Learning In Oral Radiology: Students’ Perceptions Of Training In Intraoral Radiographic Techniques Across Two Dental Institutes, Abeer A. Almashraqi, Ankur Jethlia, Rebecca Glanville, Hanin Daas, Kamran Ali
Simulation-Based Learning In Oral Radiology: Students’ Perceptions Of Training In Intraoral Radiographic Techniques Across Two Dental Institutes, Abeer A. Almashraqi, Ankur Jethlia, Rebecca Glanville, Hanin Daas, Kamran Ali
Peninsula Dental School
Objective: Simulation-based learning (SBL) in oral radiology offers a safe, structured environment that supports students’ transition to clinical practice. However, limited research has captured students' perceptions of SBL for intraoral radiography training. This study aimed to explore the perceptions of dental students about SBL in intraoral radiography using a mixed-methods approach across two dental institutions. Methods: Third-year undergraduate dental students from two institutions were recruited. All students were trained on both periapical (paralleling technique in Institution A and bisecting angle technique in Institution B) and bitewing radiographs using a mannequin. Data were collected through a 9-item Likert-scale survey and three …
Cetrimide Vs Sodium Chloride: Postoperative Wound Cleansing Practice, A Clinical Audit Project Proposal, Andrei Niga
Cetrimide Vs Sodium Chloride: Postoperative Wound Cleansing Practice, A Clinical Audit Project Proposal, Andrei Niga
South West Clinical School Journal
No abstract provided.
Development Of A Therapy-Led Follow Up Model For Patients With Long-Term Neurological Conditions Seen In A Rural Spasticity Clinic, Angela Gibbon
Development Of A Therapy-Led Follow Up Model For Patients With Long-Term Neurological Conditions Seen In A Rural Spasticity Clinic, Angela Gibbon
South West Clinical School Journal
No abstract provided.
Evaluating The Impact Of A Language Translation Standard Operating Procedure For The Multi-Professional Team Working In A Maternity Care Service, Fiona Howard
South West Clinical School Journal
No abstract provided.
Neuroprotection Of Patients After An Out-Of-Hospital Cardiac Arrest: A Clinical Audit Project Proposal, Rebecca Russell
Neuroprotection Of Patients After An Out-Of-Hospital Cardiac Arrest: A Clinical Audit Project Proposal, Rebecca Russell
South West Clinical School Journal
No abstract provided.
Nurses’ Knowledge And Practice For The Management Of Local Anaesthetic Systemic Toxicity: A Service Evaluation Project Proposal, Adeola Adebisi
Nurses’ Knowledge And Practice For The Management Of Local Anaesthetic Systemic Toxicity: A Service Evaluation Project Proposal, Adeola Adebisi
South West Clinical School Journal
No abstract provided.
Pixar Service Evaluation – Patient And Public Involvement On The Isles Of Scilly: Informing Research Through Lived Experience, Samuel Huczmann
Pixar Service Evaluation – Patient And Public Involvement On The Isles Of Scilly: Informing Research Through Lived Experience, Samuel Huczmann
South West Clinical School Journal
No abstract provided.
Theatre Staff Knowledge And Practice In The Use Of Surgical Robotics: A Service Evaluation Project Proposal, Sandhya Rani Sudhakar Puli
Theatre Staff Knowledge And Practice In The Use Of Surgical Robotics: A Service Evaluation Project Proposal, Sandhya Rani Sudhakar Puli
South West Clinical School Journal
No abstract provided.