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Identity Development, Attraction, And Behaviour Of Heterosexually-Identified Men Who Have Sex With Men: A Scoping Review, E Andrew, S Travis, K Taylor, P Nelson, K Sandra, M Mel, D Frank, M Lauren, B Oliver, B Erin, B Adam, V Daniel, B Cara, S Paul, O Beer Sep 2023

Identity Development, Attraction, And Behaviour Of Heterosexually-Identified Men Who Have Sex With Men: A Scoping Review, E Andrew, S Travis, K Taylor, P Nelson, K Sandra, M Mel, D Frank, M Lauren, B Oliver, B Erin, B Adam, V Daniel, B Cara, S Paul, O Beer

School of Health Professions

No abstract provided.

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Thin And Transient Meltwater Layers And False Bottoms In The Arctic Sea Ice Pack-Recent Insights On These Historically Overlooked Features, Madison M. Smith, Hélène Angot, Emelia J. Chamberlain, Elise S. Droste, Salar Karam, Morven Muilwijk, Alison L. Webb, Stephen D. Archer, Ivo Beck, Byron W. Blomquist, Jeff Bowman, Matthew Boyer, Deborah Bozzato, Melissa Chierici, Jessie Creamean, Alessandra D’Angelo, Bruno Delille, Ilker Fer, Allison A. Fong, Agneta Fransson, Niels Fuchs, Jessie Gardner, Mats A. Granskog, Clara J.M. Hoppe, Mario Hoppema, Mario Hoppmann, Thomas Mock, Sofia Muller, Oliver Müller, Marcel Nicolaus Sep 2023

Thin And Transient Meltwater Layers And False Bottoms In The Arctic Sea Ice Pack-Recent Insights On These Historically Overlooked Features, Madison M. Smith, Hélène Angot, Emelia J. Chamberlain, Elise S. Droste, Salar Karam, Morven Muilwijk, Alison L. Webb, Stephen D. Archer, Ivo Beck, Byron W. Blomquist, Jeff Bowman, Matthew Boyer, Deborah Bozzato, Melissa Chierici, Jessie Creamean, Alessandra D’Angelo, Bruno Delille, Ilker Fer, Allison A. Fong, Agneta Fransson, Niels Fuchs, Jessie Gardner, Mats A. Granskog, Clara J.M. Hoppe, Mario Hoppema, Mario Hoppmann, Thomas Mock, Sofia Muller, Oliver Müller, Marcel Nicolaus

School of Geography, Earth and Environmental Sciences

The rapid melt of snow and sea ice during the Arctic summer provides a significant source of low-salinity meltwater to the surface ocean on the local scale. The accumulation of this meltwater on, under, and around sea ice floes can result in relatively thin meltwater layers in the upper ocean. Due to the small-scale nature of these upper-ocean features, typically on the order of 1 m thick or less, they are rarely detected by standard methods, but are nevertheless pervasive and critically important in Arctic summer. Observations during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition …

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Sustainability In Nutrition & Dietetics: Where Are We Now?, F Telford-Penfound, J Smith Sep 2023

Sustainability In Nutrition & Dietetics: Where Are We Now?, F Telford-Penfound, J Smith

More Faculty of Health Research

No abstract provided.

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Three Horizons For Future Geoscience, S Iain, Angela C Maria, M Hassina, M Kombada, R Munira, M Raji Sep 2023

Three Horizons For Future Geoscience, S Iain, Angela C Maria, M Hassina, M Kombada, R Munira, M Raji

More Faculty of Science and Engineering Research

Geoscience, along with other scientific disciplines, is being increasingly challenged on how it can best confront key global challenges, such as climate change, food insecurity, biodiversity loss, human conflict and migration, and persistent poverty. But its traditional association with exploitation of the planet’s natural resources for energy and materials links it with contemporary concerns around unsustainable human practices, arguably fueling a growing disenchantment that is most evident in declining enrollment in university geoscience courses in many countries. Therefore, a fresh re-framing of the geoscience’s relationship to society would seem to be urgently needed. In response to this need, we introduce …

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Oxford Cognitive Screen: A Critical Review And Independent Psychometric Evaluation, D Murphy, E Cornford, A Higginson, A Norman, R Long, R Noad Sep 2023

Oxford Cognitive Screen: A Critical Review And Independent Psychometric Evaluation, D Murphy, E Cornford, A Higginson, A Norman, R Long, R Noad

School of Psychology

The Oxford cognitive screen (OCS) is a stroke-specific cognitive screening assessment. Although the test developers have provided psychometric information for the assessment, the OCS has received minimal external scrutiny, with which to triangulate the underpinning psychometrics. The purpose of this study is to provide a critical review and independent validation of the OCS. This study analysed data from an anonymised clinical database, which consisted of 316 patients who were assessed using the OCS on an Acute Stroke Unit. The rates of impairment on tests of memory and receptive communication were lower than expectation, suggesting that these subtests may be relatively …

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Etherstweb – An Ethereum-Based Distributed Application For User Information Trustworthiness Verification, C-G Koa, S-H Heng, J-J Chin Sep 2023

Etherstweb – An Ethereum-Based Distributed Application For User Information Trustworthiness Verification, C-G Koa, S-H Heng, J-J Chin

School of Engineering, Computing and Mathematics

Fake news and misinformation are prevalent on the Internet in this day and age. The popularity of social media such as Facebook, Instagram, TikTok has encouraged the people to share news or information over Internet without knowing whether it is a truth or fake information. The outbreak of COVID-19 affected the social activities of all levels of society as people were asked to stay at home to self-quarantine. It indirectly encourages the growth of the social activities online. Even though COVID- 19 is no longer a big threat to the world, people already used to rely on the Internet for …

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Simulating Peers: Can Puppets Simulate Peer Interactions In Studies On Children's Socio‐Cognitive Development?, Roman Stengelin, Daniel B.M. Haun, Patricia Kanngiesser Sep 2023

Simulating Peers: Can Puppets Simulate Peer Interactions In Studies On Children's Socio‐Cognitive Development?, Roman Stengelin, Daniel B.M. Haun, Patricia Kanngiesser

School of Psychology

Interactions with peers are fundamental to socio‐cognitive development, but assessing peer interactions in standardized experiments is challenging. Therefore, researchers commonly utilize puppetry to simulate peers. This Registered Report investigated urban German children's (Age Range> = 3.5–4.5 years; N = 144; 76♀) mind ascriptions and social cognition to test whether they treat puppets like peers, adults, or neither. Children attributed less mind properties to puppets than peers or adults. However, children's social cognition (i.e., normativity, prosociality, and theory of mind) varied little across partners. Puppetry relies on children's ability for pretense, but can provide valid insights into socio‐cognitive development. Implications for …

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How Safety Culture Surveys Influence The Quality And Safety Of Healthcare Organisations, Rm Bethune, S Ball, N Doran, M Harris, A Medina-Lara, M Fornasiero, M Hill, I Lang, J Mcgregor-Harper, R Sheaff Sep 2023

How Safety Culture Surveys Influence The Quality And Safety Of Healthcare Organisations, Rm Bethune, S Ball, N Doran, M Harris, A Medina-Lara, M Fornasiero, M Hill, I Lang, J Mcgregor-Harper, R Sheaff

Peninsula Medical School

Objectives Safety culture surveys have been widely used in healthcare for more than two decades predominantly as a tool for measuring the level of safety culture (as defined as the beliefs and attitudes that staff express about how their organisation ought to work and how it does in fact work). However, there is the potential for the survey process itself to influence the safety culture and working practices in departments and organisations. The objective of this study was to identify the mechanism by which these changes might occur. Design, setting and participants Mixed methods combining qualitative semi-structured interviews and quantitative …

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Fatigue At Sea During And After The Covid-19 Pandemic: A Comparative Study Of Two Matched Samples Of Seafarers, Zhiwei Zhao, Lijun Tang, Yunlei Ma, Yueyan Wu, Shiqi Lin, Zefan Wu, Zheng Zhou, Xinyi Wang, Xinjian Wang Sep 2023

Fatigue At Sea During And After The Covid-19 Pandemic: A Comparative Study Of Two Matched Samples Of Seafarers, Zhiwei Zhao, Lijun Tang, Yunlei Ma, Yueyan Wu, Shiqi Lin, Zefan Wu, Zheng Zhou, Xinyi Wang, Xinjian Wang

Plymouth Business School

This paper examines seafarers’ experience of fatigue during and after the pandemic. A multi-phase mixed methods research design was used, including two quantitative surveys (Nduring-pandemic=501 and Nafter-pandemic=412) and 36 in-depth interviews. Applying propensity score matching the two samples to approximate the conditions of a randomized controlled experiment, the study shows that surprisingly seafarers reported higher levels of fatigue after the pandemic. Qualitative interviews with seafarers and ship managers reveal the underlying reason – the intensified ship inspection regime together with policy and regulatory updates/revisions in the immediate aftermath of the pandemic increased seafarers’ workload and made seafarers more fatigued. The …

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Transcranial Focused Ultrasound-Mediated Neurochemical And Functional Connectivity Changes In Deep Cortical Regions In Humans, Siti N. Yaakub, Tristan A. White, Jamie Roberts, Eleanor Martin, Lennart Verhagen, Charlotte J. Stagg, Stephen Hall, Elsa F. Fouragnan Sep 2023

Transcranial Focused Ultrasound-Mediated Neurochemical And Functional Connectivity Changes In Deep Cortical Regions In Humans, Siti N. Yaakub, Tristan A. White, Jamie Roberts, Eleanor Martin, Lennart Verhagen, Charlotte J. Stagg, Stephen Hall, Elsa F. Fouragnan

School of Psychology

Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive technique for focally modulating human brain function. The mechanisms and neurochemical substrates underlying TUS neuromodulation in humans and how these relate to excitation and inhibition are still poorly understood. In 24 healthy controls, we separately stimulated two deep cortical regions and investigated the effects of theta-burst TUS, a protocol shown to increase corticospinal excitability, on the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and functional connectivity. We show that theta-burst TUS in humans selectively reduces GABA levels in the posterior cingulate, but not the dorsal anterior cingulate cortex. Functional connectivity increased following TUS …

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Evaluation Of A Study Protocol Of The Application Of Humor Interventions In Palliative Care Through A First Pilot Study, Lisa Linge-Dahl, Sonja Heintz, Willibald Ruch, Maria Bley, Hirschhausen E Von, Lukas Radbruch Sep 2023

Evaluation Of A Study Protocol Of The Application Of Humor Interventions In Palliative Care Through A First Pilot Study, Lisa Linge-Dahl, Sonja Heintz, Willibald Ruch, Maria Bley, Hirschhausen E Von, Lukas Radbruch

School of Psychology

Background: Humor and laughter might have an alleviating effect on pain threshold and enhance coping and building relationships. However, randomized controlled studies in palliative care have struggled with high percentages of attrition and missing values. Objectives: We aimed to evaluate a study protocol through a pilot study for the evaluation of a multistage humor intervention with psychological and physiological outcome parameters that may be applied successfully in a palliative care environment. Design: This pilot study utilized a pre–post design. The inclusion of a control group for the final study setting recruiting 120 patients is planned. Setting/Subjects: The study was a …

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Restoration Management Of Phosphorus Pollution On Lowland Fen Peatlands: A Data Evidence Review From The Somerset Levels And Moors, Sean Comber, Paul Lunt, Mark Taylor, Natasha Underwood, Ry Crocker, Rob Schindler Sep 2023

Restoration Management Of Phosphorus Pollution On Lowland Fen Peatlands: A Data Evidence Review From The Somerset Levels And Moors, Sean Comber, Paul Lunt, Mark Taylor, Natasha Underwood, Ry Crocker, Rob Schindler

School of Geography, Earth and Environmental Sciences

Eutrophication of wetlands caused by urban, industrial and agricultural run-off is an important environmental problem. Eutrophication is characterized by excessive plant and algal growth due to the increased availability of one or more growth “limiting nutrients”, in freshwater generally considered to be controlled by the bioavailability of phosphorus (P). The Somerset Levels and Moors (SLMs) catchments are subject to intensive agriculture and wastewater inputs which leads to nutrient contamination of the inflow waters, to the extent that they fail Water Framework Directive Good Status targets for P concentrations. In 2021, Natural England downgraded the status of the SLMs Sites of …

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Longitudinal Realist Evaluation Of The Dementia Personalised Care Team (D-Pact) Intervention: Protocol, Hannah Wheat, Lauren Weston, Tomasina M. Oh, Sarah Morgan-Trimmer, Wendy Ingram, Sarah Griffiths, Rod Sheaff, Paul Clarkson, Antonieta Medina-Lara, Crispin Musicha, Stuart Spicer, Obioha Ukoumunne, Victoria Allgar, Siobhan Creanor, Michael Clark, Cath Quinn, Alex Gude, Rose Mccabe, Saqba Batool, Lorna Smith, Debra Richards, Hannah Shafi, Bethany Warwick, Reena Lasrado, Basharat Hussain, Hannah Jones, Sonia Dalkin, Angela Bate, Ian Sherriff, Louise Robinson, Richard Byng Sep 2023

Longitudinal Realist Evaluation Of The Dementia Personalised Care Team (D-Pact) Intervention: Protocol, Hannah Wheat, Lauren Weston, Tomasina M. Oh, Sarah Morgan-Trimmer, Wendy Ingram, Sarah Griffiths, Rod Sheaff, Paul Clarkson, Antonieta Medina-Lara, Crispin Musicha, Stuart Spicer, Obioha Ukoumunne, Victoria Allgar, Siobhan Creanor, Michael Clark, Cath Quinn, Alex Gude, Rose Mccabe, Saqba Batool, Lorna Smith, Debra Richards, Hannah Shafi, Bethany Warwick, Reena Lasrado, Basharat Hussain, Hannah Jones, Sonia Dalkin, Angela Bate, Ian Sherriff, Louise Robinson, Richard Byng

Peninsula Medical School

Background: Different dementia support roles exist but evidence is lacking on which aspects are best, for whom, and in what circumstances, and on their associated costs and benefits. Phase 1 of the Dementia PersonAlised Care Team programme (D-PACT) developed a post-diagnostic primary care-based intervention for people with dementia and their carers and assessed the feasibility of a trial. Aim: Phase 2 of the programme aims to 1) refine the programme theory on how, when, and for whom the intervention works; and 2) evaluate its value and impact. Design & setting: A realist longitudinal mixed-methods evaluation will be conducted in urban, …

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Uk Speech And Language Therapists’ Assessment Of Children's Expressive Language, And Functional Impairment And Impact, Following The Catalise Publications, Hannah Waine, Sally Bates, Pauline Frizelle, Tomasina M. Oh Sep 2023

Uk Speech And Language Therapists’ Assessment Of Children's Expressive Language, And Functional Impairment And Impact, Following The Catalise Publications, Hannah Waine, Sally Bates, Pauline Frizelle, Tomasina M. Oh

Peninsula Medical School

Background: In 2016/17, the CATALISE Consortium published the results of a multinational and multidisciplinary Delphi consensus study, representing agreement among professionals about the definition and process of identification of children with Developmental Language Disorder (DLD) (Bishop et al., 2016, 2017). The extent to which the current clinical practice of UK speech and language therapists (SLTs) reflects the CATALISE consensus statements is unknown. Aims: To investigate how UK SLTs’ expressive language assessment practices reflect the CATALISE documents’ emphasis on the functional impairment and impact caused by DLD, by examining: whether multiple sources of assessment information are gathered; how standardised and non-standardised …

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The Role Of Digital Transformation In Addressing Health Inequalities In Coastal Communities: Barriers And Enablers, Sheena Asthana, Samantha Prime Aug 2023

The Role Of Digital Transformation In Addressing Health Inequalities In Coastal Communities: Barriers And Enablers, Sheena Asthana, Samantha Prime

Peninsula Medical School

Healthcare systems worldwide are striving for the “quadruple aim” of better population health and well-being, improved experience of care, healthcare team well-being (including that of carers) and lower system costs. By shifting the balance of care from reactive to preventive by facilitating the integration of data between patients and clinicians to support prevention, early diagnosis and care at home, many technological solutions exist to support this ambition. Yet few have been mainstreamed in the NHS. This is particularly the case in English coastal areas which, despite having a substantially higher burden of physical and mental health conditions and poorer health …

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Deep-Learning Predicted Pet Can Be Subtracted From The True Clinical Fluorodeoxyglucose Pet Co-Registered To Mri To Identify The Epileptogenic Zone In Focal Epilepsy, A Flaus, J Jung, K Ostrowky‐Coste, S Rheims, Et Al Aug 2023

Deep-Learning Predicted Pet Can Be Subtracted From The True Clinical Fluorodeoxyglucose Pet Co-Registered To Mri To Identify The Epileptogenic Zone In Focal Epilepsy, A Flaus, J Jung, K Ostrowky‐Coste, S Rheims, Et Al

School of Psychology

Objective Normal interictal [18F]FDG-PET can be predicted from the corresponding T1w MRI with Generative Adversarial Networks (GANs). A technique we call SIPCOM (Subtraction Interictal PET Co-registered to MRI) can then be used to compare epilepsy patients' predicted and clinical PET. We assessed the ability of SIPCOM to identify the Resection Zone (RZ) in patients with drug-resistant epilepsy (DRE) with reference to visual and statistical parametric mapping (SPM) analysis. Methods Patients with complete presurgical work-up and subsequent SEEG and cortectomy were included. RZ localisation, the reference region, was assigned to one of eighteen anatomical brain regions. SIPCOM was implemented using healthy …

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Practical Diagnosis Of Cirrhosis In Non-Alcoholic Fatty Liver Disease Using Currently Available Non-Invasive Fibrosis Tests, J Boursier, Marine Roux, Charlotte Costentin, Julien Chaigneau, Céline Fournier-Poizat, Aldo Trylesinski, Cm Canivet, Sophie Michalak, Bail B Le, Valérie Paradis, Pierre Bedossa, Nathalie Sturm, Ledinghen V De, Justine Barthelon, J Boursier, Paul Cales, C Canivet, Thomas Decaens, Adèle Delamarre, Paul Hermabessiere, Marie Irles-Depé, Ledinghen V De, Marie Noelle Hilleret, Isabelle Fouchard-Hubert, Adrien Lannes, Bail B Le, Valérie Moal, Fréderic Oberti, Michael Allison, Peter J. Eddowes, Jeremy F. Cobbold, Jonathan J. Deeks, Peter J. Eddowes, Indra N. Guha, David Sheridan, Emmanuel Tsochatzis, Philip N. Newsome Aug 2023

Practical Diagnosis Of Cirrhosis In Non-Alcoholic Fatty Liver Disease Using Currently Available Non-Invasive Fibrosis Tests, J Boursier, Marine Roux, Charlotte Costentin, Julien Chaigneau, Céline Fournier-Poizat, Aldo Trylesinski, Cm Canivet, Sophie Michalak, Bail B Le, Valérie Paradis, Pierre Bedossa, Nathalie Sturm, Ledinghen V De, Justine Barthelon, J Boursier, Paul Cales, C Canivet, Thomas Decaens, Adèle Delamarre, Paul Hermabessiere, Marie Irles-Depé, Ledinghen V De, Marie Noelle Hilleret, Isabelle Fouchard-Hubert, Adrien Lannes, Bail B Le, Valérie Moal, Fréderic Oberti, Michael Allison, Peter J. Eddowes, Jeremy F. Cobbold, Jonathan J. Deeks, Peter J. Eddowes, Indra N. Guha, David Sheridan, Emmanuel Tsochatzis, Philip N. Newsome

Peninsula Medical School

Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohorts. The study algorithm, using first the elastography-based tests Agile3+ and Agile4 and then the specialized blood tests FibroMeterV3G and CirrhoMeterV3G, provides stratification in four groups, the last of which is enriched in cirrhosis (71% prevalence in the validation set). A risk prediction chart is also derived to allow estimation of the individual probability of …

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Editorial: Assessment Of Pain In The Older Population, Pat Schofield, Irmela Gnass Aug 2023

Editorial: Assessment Of Pain In The Older Population, Pat Schofield, Irmela Gnass

School of Nursing and Midwifery

For many years now we have proposed that pain is regularly assessed and fundamental to the management process. To date, there has been a great deal of research exploring the most appropriate pain assessment tools and great strides have been made in their implementation. Assessment of pain in the older population has presented challenges, especially when there are communication difficulties, as seen in adults with dementia or other communication issues. Pain is not a natural part of the ageing process and people should not be expected to live with it. In recent years, there has been recognition that stoicism does …

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An Adaptive Cybersecurity Training Framework For The Education Of Social Media Users At Work, Salamah F Ben, Marco A. Palomino, Matthew J. Craven, Maria Papadaki, Steven Furnell Aug 2023

An Adaptive Cybersecurity Training Framework For The Education Of Social Media Users At Work, Salamah F Ben, Marco A. Palomino, Matthew J. Craven, Maria Papadaki, Steven Furnell

School of Engineering, Computing and Mathematics

Formalizing the approach towards risk management on social media is critical for organizations. Regrettably, a review of the state-of-the-art on cybersecurity training highlighted that the existing frameworks are either too generic or too cumbersome to be adapted to different organizations and needs. Thus, we developed the Adaptive Cybersecurity Training Framework for Social Media Risks (ACSTF-SMR), a framework that incorporates social media cybersecurity policies and best practices. The ACSTF-SMR enables organizations, trainers, and policymakers to address the challenges posed by social media in a way that satisfies employees’ training needs and adjusts to their preferences. We tested the ACSTF-SMR with 38 …

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Impact Of Trust In Virtual Project Teams: Structural Equation Modeling (Sem) Approach, Sukhwant Kaur Sagar, Olugbenga Timo Oladinrin, Mohammed Arif, Amit Kaushik, Rubina Islam Aug 2023

Impact Of Trust In Virtual Project Teams: Structural Equation Modeling (Sem) Approach, Sukhwant Kaur Sagar, Olugbenga Timo Oladinrin, Mohammed Arif, Amit Kaushik, Rubina Islam

School of Art, Design and Architecture

Purpose This study aims to focus on model development to analyse key factors affecting trust in virtual project teams (VPTs). Design/methodology/approach A questionnaire survey was conducted on construction professionals participating in virtual teams. Structural equation modelling technique was performed to establish the effect of relevant factors on trust-building in VPTs. Findings Team performance is highly affected by the trust among the team members. Trust building can be enhanced by improving the quality of team communication, organisation culture, team bonding and team members’ characteristics. Originality/value The model developed in this study would benefit team productivity and team members’ learning in VPTs.

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Northerly Range Expansion And First Confirmed Records Of The Smalltooth Sand Tiger Shark, Odontaspis Ferox, In The United Kingdom And Ireland, David J. Curnick, Phil Hosegood Aug 2023

Northerly Range Expansion And First Confirmed Records Of The Smalltooth Sand Tiger Shark, Odontaspis Ferox, In The United Kingdom And Ireland, David J. Curnick, Phil Hosegood

School of Biological and Marine Sciences

Three Odontaspis ferox (confirmed by mtDNA barcoding) were found in the English Channel and Celtic Sea in 2023 at Lepe, UK (50.7846, −1.3508), Kilmore Quay, Ireland (52.1714, −6.5937), and Lyme Bay, UK (50.6448, −2.9302). These are the first records of O. ferox in either country, and extend the species' range by over three degrees of latitude, to >52° N. They were ~275 (female), 433 (female), and 293 cm (male) total length, respectively. These continue a series of new records, possibly indicative of a climate change−induced shift in the species' range.

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How Can Patients Be In Control Of Their Healthcare If They Are Not In Control Of Their Online Health Information?, M Hägglund, A Kharko, J Hagström, M Johansen, Et Al Aug 2023

How Can Patients Be In Control Of Their Healthcare If They Are Not In Control Of Their Online Health Information?, M Hägglund, A Kharko, J Hagström, M Johansen, Et Al

Peninsula Medical School

No abstract provided.

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In Silico Prediction Of Acute Chemical Toxicity Of Biocides In Marine Crustaceans Using Machine Learning, Rama Krishnan, Ian S. Howard, Sean Comber, Awadhesh N. Jha Aug 2023

In Silico Prediction Of Acute Chemical Toxicity Of Biocides In Marine Crustaceans Using Machine Learning, Rama Krishnan, Ian S. Howard, Sean Comber, Awadhesh N. Jha

School of Engineering, Computing and Mathematics

Biocides are a heterogeneous group of chemical substances intended to control the growth or kill undesired organisms. Due to their extensive use, they enter marine ecosystems via non-point sources and may pose a threat to ecologically important non-target organisms. Consequently, industries and regulatory agencies have recognized the ecotoxicological hazard potential of biocides. However, the prediction of biocide chemical toxicity on marine crustaceans has not been previously evaluated. This study aims to provide in silico models capable of classifying structurally diverse biocidal chemicals into different toxicity categories and predict acute chemical toxicity (LC50) in marine crustaceans using a set of calculated …

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Patient-Reported Outcomes In Multiple Sclerosis: A Prospective Registry Cohort Study, Annalaura Lerede, Jeff Rodgers, Rod M. Middleton, Adam Hampshire, Richard Nicholas, Alasdair Coles, Jeremy Chataway, Martin Duddy, Hedley Emsley, H Ford, Leonora Fisniku, Ian Galea, Timothy Harrower, Jeremy Hobart, Huseyin Huseyin, Christopher M. Kipps, Monica Marta, Gavin V. Mcdonnell, Brendan Mclean, Owen Pearson, David Rog, Klaus Schmierer, Basil Sharrack, Agne Straukiene, Dv Ford Aug 2023

Patient-Reported Outcomes In Multiple Sclerosis: A Prospective Registry Cohort Study, Annalaura Lerede, Jeff Rodgers, Rod M. Middleton, Adam Hampshire, Richard Nicholas, Alasdair Coles, Jeremy Chataway, Martin Duddy, Hedley Emsley, H Ford, Leonora Fisniku, Ian Galea, Timothy Harrower, Jeremy Hobart, Huseyin Huseyin, Christopher M. Kipps, Monica Marta, Gavin V. Mcdonnell, Brendan Mclean, Owen Pearson, David Rog, Klaus Schmierer, Basil Sharrack, Agne Straukiene, Dv Ford

Peninsula Medical School

Registries have the potential to tackle some of the current limitations in determining the long-term impact of multiple sclerosis. Online assessments using patient-reported outcomes can streamline follow-up enabling large-scale, long-term, cost-effective, home-based, and patient-focused data collection. However, registry data are sparsely sampled and the sensitivity of patient-reported outcomes relative to clinician-reported scales is unknown, making it hard to fully leverage their unique scope and scale to derive insights. This retrospective and prospective cohort study over 11 years involved 15 976 patients with multiple sclerosis from the United Kingdom Multiples Sclerosis Register. Primary outcomes were changes in two patient-reported outcomes: Multiple …

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Trust, Transgression And Surrender: Exploring Teacher And Send Student Perceptions Of Engagement With Creative Arts Project-Based Learning (Capbl) Pedagogies, James Tarling Aug 2023

Trust, Transgression And Surrender: Exploring Teacher And Send Student Perceptions Of Engagement With Creative Arts Project-Based Learning (Capbl) Pedagogies, James Tarling

School of Law, Humanities and Social Sciences

CAPBL is an example of a student-led, Creative Arts/Project-Based Learning (CAPBL/PBL) curriculum approach to working with Special Educational Needs and Disabilities (SEND) learners. This mixed-methods, quasi-experimental study seeks to explore staff and student perceptions of working in this way and establish key themes for practice in relation to equity and inclusion. Although the literature on PBL is widespread, CAPBL is novel in that it brings these ideas to a specialist SEND, Creative Arts, post-16 context, Further Education (FE), with a particular focus on arts education currently absent from the existing literature. This small-scale research project is positioned as a participant-led …

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Keeping The Port Of Tema Afloat During Covid-19: Media Responses To User Informational And Conversational Needs, Martin Arvad Nicolaisen, Casper Andersen, Phillip Stenmann Baun, Jonas Aryee, Annette Skovsted Hansen Aug 2023

Keeping The Port Of Tema Afloat During Covid-19: Media Responses To User Informational And Conversational Needs, Martin Arvad Nicolaisen, Casper Andersen, Phillip Stenmann Baun, Jonas Aryee, Annette Skovsted Hansen

Plymouth Business School

Two different media platforms played a key role in keeping Tema Port in Ghana afloat during the period immediately leading up to and during the three-week COVID-19 pandemic-related lockdown in late March–April of 2020. The one media platform, Eye on Port, is a weekly broadcast television show by the port’s authorities, which caters primarily to external commercial stakeholders of the port. The other platform is a closed WhatsApp forum used by stakeholders working at the operational level of the port. Both platforms served specific needs among their users, who had been restricted in their mobility but had to keep the …

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Early-Phase Neuroplasticity Induced By Offline Transcranial Ultrasound Stimulation In Primates, N Bault, Sn Yaakub, E Fouragnan Aug 2023

Early-Phase Neuroplasticity Induced By Offline Transcranial Ultrasound Stimulation In Primates, N Bault, Sn Yaakub, E Fouragnan

School of Psychology

No abstract provided.

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From The Individual To The Organisation: Transferring Learning From Global Health Projects Into Organisational Change, A Inman, L Spowart, L Hardy, M Dillon Aug 2023

From The Individual To The Organisation: Transferring Learning From Global Health Projects Into Organisational Change, A Inman, L Spowart, L Hardy, M Dillon

Peninsula Medical School

No abstract provided.

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Toll-Like Receptor 4 And Macrophage Scavenger Receptor 1 Crosstalk Regulates Phagocytosis Of A Fungal Pathogen, Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May Aug 2023

Toll-Like Receptor 4 And Macrophage Scavenger Receptor 1 Crosstalk Regulates Phagocytosis Of A Fungal Pathogen, Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May

School of Biomedical Sciences

The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognised and phagocytosed by macrophages. Here we investigate the role of TLR4 in the non-opsonic phagocytosis of C. neoformans. We find that loss of TLR4 function unexpectedly increases phagocytosis of non-opsonised cryptococci by murine and human macrophages. The increased phagocytosis observed in Tlr4−/− cells was dampened by pre-treatment of macrophages with oxidised-LDL, a known ligand of scavenger receptors. The scavenger receptor, macrophage scavenger receptor 1 (MSR1) (also known as SR-A1 or …

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Ocean-Based Climate Action And Human Rights Implications Under The International Climate Change Regime, Elisa Morgera, Mitchell Lennan, Kati Kulovesi, Bianca G La, Holly J. Niner, Ellycia Harrould-Kolieb, Piva E Recio, Jeremy Hills, Mara Ntona, Alana Malinde Sn Lancaster, Mia Strand, Bernadette Snow, Kira Erwin, Lynne Shannon, Sian Rees, Kieran Hyder, Georg Engelhard, Kerry Howell Aug 2023

Ocean-Based Climate Action And Human Rights Implications Under The International Climate Change Regime, Elisa Morgera, Mitchell Lennan, Kati Kulovesi, Bianca G La, Holly J. Niner, Ellycia Harrould-Kolieb, Piva E Recio, Jeremy Hills, Mara Ntona, Alana Malinde Sn Lancaster, Mia Strand, Bernadette Snow, Kira Erwin, Lynne Shannon, Sian Rees, Kieran Hyder, Georg Engelhard, Kerry Howell

School of Biological and Marine Sciences

After drawing attention to the crucial role of marine biodiversity, including that of deep-sea ecosystems, in current scientific understanding of the ocean-climate nexus, this article highlights the limited extent to which the international climate change regime has so far addressed the ocean. The focus then shifts to how the international climate change regime could contribute to the protection of marine biodiversity as part of mitigation, adaptation and finance, taking into account human rights impacts and standards, drawing a comparison with REDD+. The article concludes with an original proposal, inspired by the Climate and Clean Air Coalition, to develop urgent, synergistic …

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