Digital Commons Network^™

Phosphorylation And Regulation Of The Dopamine Transporter By Psychostimulant Substrates And Protein -Protein Interactions, Mark A. Cervinski

Theses and Dissertations

The dopamine transporter (DAT) is an integral membrane protein that clears dopamine (DA) from the synaptic space following neurotransmission. DATs amino acid sequence contains numerous serine, threonine and tyrosine residues, some of which are located in protein kinase consensus sites. While DAT phosphorylation and regulation in response to protein kinase C activation is well documented, evidence suggests that multiple signals and interacting proteins also mediate these processes. Previous research has also demonstrated that DAT regulation is influenced by the presence of the DAT substrates amphetamine (AMPH), methamphetamine (METH) and the uptake blocker cocaine. Using 32PO4 metabolic labeling and [3H]DA uptake …

Optimism As A Buffer Against The Negative Impact Of Discrimination, Betsi Little

Theses and Dissertations

Research has shown that the general expectancy for positive outcomes, optimism, has been linked closely with the ability to positively cope with adverse life events, such as cancer, stress and depression. Being discriminated against has been shown to be a stressful event that has a negative psychological impact such as lowering self-esteem. Traits that have been linked with optimism, such as hardiness and self-efficacy have also been found to help combat the effects of discrimination among women. Although these traits implicate the role of optimism, to date, the possible effect of optimism itself as a buffer against the negative effects …

Decreased Renal Basement Membrane Thickening Is Accompanied By Elevated Renal Antioxidants In The Ames Dwarf Mouse Model Of Delayed Aging, Mandy M. Meyer

Theses and Dissertations

Experimental evidence suggests that disease- and age-related thickening of glomerular (GBM) and tubular (TBM) basement membranes may be related to increases in reactive oxygen species (ROS). Studies also suggest that antioxidants may function as renoprotectants against such ROS-induced damage. The current study focuses on metallothionein-I/II (MT-I/II) and glutathione (GSH), both of which exhibit potent antioxidant functions. Ames dwarf mice, which exhibit elevated tissue antioxidant levels (catalase, Cu/Zn superoxide dismutase, GSH) and an average life span significantly greater (50-65%) than wild type controls, were used to test our hypothesis that increased levels of renal MT-I/II and GSH are concomitant with decreased …

Volume 44, Number 55: March 08, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 44, Number 54: March 06, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

March 1, 2007, University Of North Dakota

University Senate Meeting Minutes

Minutes from the March 1, 2007, meeting of the University Senate. 7 pages

Volume 44, Number 52: February 27, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 44, Number 51: February 22, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 44, Number 49: February 15, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 44, Number 46: February 06, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Computer Simulations Of Glyceraldehyde -3 -Phosphate Dehydrogenase Interactions With Actin And Fructose -1,6 -Bisphosphate Aldolase, And Substrate Binding Dynamics, Victor F. Waingeh

Theses and Dissertations

The association of glycolytic enzymes with cytoskeletal proteins such as actin is thought to be a structural basis for compartmentation of the glycolytic pathway. It is also suggested that such interactions bring glycolytic enzymes within close proximity to each other so that substrate transfer between sequential enzymes is faster. Brownian dynamics (BD) simulations were used to study the binding of glyceraldehydes-3-phosphate dehydrogenase (GAPDH) to actin and fructose- 1,6-bisphosphate aldolase (aldolase) in different species, and the dynamics of substrate binding. High-resolution three-dimensional models of the proteins used in the simulations were either obtained from X-ray structures or built by homology modeling. …

Kinetics And Mechanism Of The Reaction Of Cobalt Tetrasulfophthalocyanine With Thiolates In The Merox Process, Eduard M. Tyapochkin

Theses and Dissertations

Binding and kinetic studies of the thiolates/thioacid salts complexation with cobalt tetrasulfophthalocyanine (CoIITSPc) in aqueous solutions, dimethylformamide (DMF), and other polar aprotic solvents were conducted using UV-vis, 1H NMR, and ESR methods under anaerobic conditions. In DMF thiolates react with CoIITSPc with 1:1 stoichiometry. Aliphatic thiolates, regardless of their basicity, reduce Co IITSPc to CoITSPc. Low-basicity thiolates form unstable (RS-)CoIITSPe complexes as dead-end products. Indirect kinetic evidence was obtained for the electron transfer from the axial ligand to metal via the phthalocyanine equatorial ligand. 1H NMR and binding studies revealed sulfur-cobalt interactions in the CoITSPc product, indicating axial ligand attachment …

Volume 44, Number 45: February 01, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 44, Number 44: January 30, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

2006 Awards Banquet, University Of North Dakota

UND Athletics Publications: Football

Program for the 2006 UND Football Awards Banquet. The event was held in the Memorial Union on January 27, 2007.

Volume 44, Number 43: January 25, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 44, Number 42: January 23, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 44, Number 41: January 18, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 44, Number 40: January 16, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

Volume 44, Number 38: January 09, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

The Municipal Ideal And The Unknown End: A Resolution Of Oliver Wendell Holmes, Michael F. Duggan, Ph.D

North Dakota Law Review

No abstract provided.

In The Shadow Of The False Claims Act: "Outsourcing" The Investigation By Government Counsel To Relator Counsel During The Seal Period, Robert Fabrikant, Nkechinyem Nwabuzor

North Dakota Law Review

No abstract provided.

Does The Family Have A Future?, William C. Duncan

North Dakota Law Review

No abstract provided.

Custody And Parenting By Persons Other Than Biological Parents: When Non-Traditional Family Law Collides With The Constitution, Gary A. Debele

North Dakota Law Review

No abstract provided.

Vol. 32, No. 1: Winter 2007, School Of Medicine & Health Sciences

North Dakota Medicine Archive

No abstract provided.

Electromyographic Analysis Of Abdominal And Low Back Musculature During Use Of An Experimental Stationary Bicycle, Bryce A. Kelly, Christopher L. Podoll, Kirk R. Van Slyke

Physical Therapy Scholarly Projects

Background and Purpose. Currently, stationary bicycles do not incorporate exercise for the abdominal and low back musculature. An experimental stationary bicycle, the Magnus Cycle, has been developed to increase trunk muscle activation and, at the same time, provide aerobic conditioning. The purpose of this study is to assess the activity of the rectus abdominus, external oblique, erector spinae, rectus femoris and biceps femoris muscles during a stationary cycling setting and during a tilt-in-space setting of the Magnus Cycle.

Subjects. Sixteen subjects, both men and women, between the ages of 18 and 30 participated in this study.

Methods. Surface electromyography (EMG) …

Cumulative Index, North Dakota Law Review

North Dakota Law Review

No abstract provided.

The Attack On Marriage As The Union Of A Man And A Woman, Lynn D. Wardle

North Dakota Law Review

No abstract provided.

Winter 2007, University Of North Dakota Alumni Association

ALL: UND Alumni Review Master List

Winter 2007 issue of "The University of North Dakota Alumni Review." 40 pages

Volume 90, Number 1

January 11, 2007, University Of North Dakota

University Senate Meeting Minutes

Minutes from the January 11, 2007, meeting of the University Senate. 31 pages