Digital Commons Network^™

20220111_Covidence Now Available To Unm Researchers, Laura J. Hall

HSLIC Blog Post

No abstract provided.

Interlaboratory Performance In Measurement Of Dabigatran And Rivaroxaban, Oksana Volod, Marian Rollins-Raval, Andrew J. Goodwin, Russell A. Higgins, Thomas Long, Wayne L. Chandler, Neil Sa Harris, Huy P. Pham, James Alexander Isom, Karen Moser, John D. Olson, Kristi J. Smock, Amanda Vansandt, Geoffrey Wool, Dong Chen

Pathology Research and Scholarship

CONTEXT.—: Assessing direct oral anticoagulant (DOAC) drug levels by reliable laboratory assays is necessary in a number of clinical scenarios.

OBJECTIVE.—: To evaluate the performance of DOAC-specific assays for various concentrations of dabigatran and rivaroxaban, assess the interlaboratory variability in measurement of these DOACs, and investigate the responsiveness of the routine clotting assays to various concentrations of these oral anticoagulants.

DESIGN.—: College of American Pathologists proficiency testing survey data from 2013 to 2016 were summarized and analyzed.

RESULTS.—: For dabigatran, the interlaboratory coefficient of variation (CV) of ecarin chromogenic assay was broad (ranging from 7.5% to 29.1%, 6.3% to 15.5%, …

Groundwater Law, The San Luis Valley, And Climate Change, Rachel Grabenstein

Student Published Scholarship

A vast region of the western United States is in the grips of the first climate change-induced megadrought observed in the past 1,200 years.

This paper explores how climate change and the current groundwater legal regimes interact in Colorado’s San Luis Valley. The Valley was chosen as a case study because it is an example of a community that introduced voluntary measures to address the overuse of groundwater. This paper examines how those measures might have been sufficient if not for the additional challenge of climate change.

This paper will first explain the history of water management in the Valley. …

Beyond Bake Sales: Environmental Justice Through Superfund Removal Actions, Clifford Villa

Faculty Scholarship

Few people outside of EPA seem to be aware of the existence of the Superfund removal program, a program through which millions of dollars are allocated through EPA’s ten regional offices each year for cleaning up contaminated sites that are not designated 'Superfund' sites. This essay will provide a basic introduction to the Superfund removal program and particularly encourage consideration of Superfund removals to address growing concerns for environmental justice. Part II examines the legal authorities and limitations of the Superfund removal program. Part III provides examples of removal actions in environmental justice communities across the country. Part IV considers …

Issue No. 117: Fall 2022

La Crónica de Nuevo México

TABLE OF CONTENTS

2 A Letter From the President

3 Bosque Redondo Memorial by Heidi Toth

11 Naal Tsoos Saní by Makayla Martinez

16 The Albuquerque Eight by Herbert D. Teel Jr. and Deborah C. Slaney

23 The Edgar Sisters of Missouri and Santa Fe by Doyle Daves

27 National History Day: Developing Young Historians by Heather McClenahan

31 Nina Otero-Warren honored by Judy and Dennis Reinhartz

33 2022 book and service award winners

34 HSNM remembers Dave Townsend, Marilyn Pope, Fred Nolan

35 New Books

36 Call for presentations

Integration Intrapreneurship: Implementing Innovation In A Public Healthcare Organization, Perrin Moss, Nicole Hartley, Trevor Russell

Project ECHO Bibliography

Aim: As global events impact the way organizations operate and innovate in response to regional, workforce and consumer needs, the concept of intrapreneurism is attracting growing interest from policymakers and executives, particularly within the healthcare sector. The aim of this study was to capture the key learnings from the implementation of a telementoring pilot, to understand how intrapreneurship can embed innovation within an established organization to effect more integrated healthcare.

Purpose: A qualitative approach was used with a phenomenological lens to explore the key learnings of the Project ECHO ® (Extension for Community Healthcare Outcomes) pilot implementation to provide an …

A Virtual Communication Partner Instruction Group In Support For Adults With Progressive Aphasia: Rationale, Development, And Preliminary Execution Guidelines, H Isabel Hubbard, Christie Carroll-Duhigg, John Adair, Janice Knoefel, Erika Partridge, Gary Rosenberg, Jessica D. Richardson

Brain & Behavioral Health Research Day

Aphasia is a language disorder caused by injury or disease to the language network. While naming impairment is the hallmark feature of aphasia, it can affect a person’s ability to communicate across modalities (e.g., speaking, listening, reading, and/or writing) and negatively impacts the individual's quality of life. Primary progressive aphasia (PPA) is a clinical syndrome caused by neurodegenerative disease (e.g., AD, FTD), and progression includes global cognitive and communication disruption. Communication Partner Instruction (CPI) is an evidence-based approach that focuses on instructing communication partners on how to best provide communicative support for a person with aphasia. The goal of CPI …

The Antiviral Restriction Factor Trim5 Engages Autophagy In Mitochondrial Quality Control, Bhaskar Saha, Michelle Salemi, Brett Phinney, Michael A. Mandell

Brain & Behavioral Health Research Day

The protein TRIM5α has multiple roles in anti-retroviral defense, but the mechanisms underlying TRIM5α action are unclear. Here, we used a proteomics approach to identify TRIM5α-interacting proteins. Analysis of the TRIM5α interactome found proteins participating in a wide variety of cellular functions including regulating antiviral signaling pathways. We used this data set to uncover a novel role for TRIM5α in mitophagy. Mitochondrial damage triggered the relocalization of TRIM5α to mitochondria-associated endoplasmic reticulum where TRIM5α colocalized with markers of autophagy initiation and autophagosome biogenesis. Furthermore, we found that TRIM5 was required for the recruitment of the ULK1 complex and other autophagy …

Alcohol Imagery Boosts The Reward Positivity In Individuals With Alcohol Use Disorder, Garima Singh, Ethan Campbell, Jeremy Hogeveen, Eric Claus, Katie Witkiewitz, James F. Cavanagh

Brain & Behavioral Health Research Day

The Reward Positivity (RewP) is a positive deflection in the EEG following reward receipt. Recent evidence suggests that the RewP is modulated by both reward probability as well as affective valuation (“liking”). Here we examined the sensitivity of the RewP when paired with positive affective vs. alcohol images in individuals with alcohol use disorder (AUD). We recruited 55 participants (AUD =28, Control= 27). Participants completed a reinforcement learning task (green or red screen feedback) with concurrent pictures (puppy or alcohol images). Although there was no group differences in puppy image ratings, there was a significant difference in alcohol image ratings …

Reaching The "Hard-To-Reach" Sexual And Gender Diverse Communities For Population-Based Research In Cancer Prevention And Control: Methods For Online Survey Data Collection And Management, Katie J. Myers, Talya Jaffe, Deborah A. Kanda, V Shane Pankratz, Bernard Tawfik, Emily Wu, Molly E. Mcclain, Shiraz I. Mishra, Miria Kano, Purnima Madhivanan, Prajakta Adsul

Pediatrics Research and Scholarship

Purpose: Around 5% of United States (U.S.) population identifies as Sexual and Gender Diverse (SGD), yet there is limited research around cancer prevention among these populations. We present multi-pronged, low-cost, and systematic recruitment strategies used to reach SGD communities in New Mexico (NM), a state that is both largely rural and racially/ethnically classified as a "majority-minority" state.

Methods: Our recruitment focused on using: (1) Every Door Direct Mail (EDDM) program, by the United States Postal Services (USPS); (2) Google and Facebook advertisements; (3) Organizational outreach

Results: A total of 27,369 flyers were distributed through the EDDM program and 436,177 impressions …

Volume 52 Masthead, University Of New Mexico - School Of Law

NMLR Mastheads

No abstract provided.

Adapting To A 4°C World, Clifford Villa

Faculty Scholarship

The Paris Agreement’s goal to hold warming to 1.5°-2°C above pre-industrial levels now appears unrealistic. Profs. Robin Kundis Craig and J.B. Ruhl have recently argued that because a 4°C world may be likely, we must recognize the disruptive consequences of such a world and respond by reimagining governance structures to meet the challenges of adapting to it. In this latest in a biannual series of essays, they and other members of the Environmental Law Collaborative explore what 4°C might mean for a variety of current legal doctrines, planning policies, governance structures, and institutions.

Don't Blame The Flint River, Clifford Villa

Faculty Scholarship

Since appearing in modern form fifty years ago, the Clean Water Act has proven a powerful force for environmental justice, helping to clean up urban waterways across the country. Through establishment of water quality standards and enforcement of regulatory requirements, the Clean Water Act has compelled public authorities and private companies to upgrade infrastructure and curtail
discharge of sewage and other industrial effluent. At the same time, urban communities have continued to struggle with water pollution beyond the reaches of the Clean Water Act. This Article briefly examines three such communities: the Anacostia area of Washington, D.C.; the neighborhoods along …

The Constitutional Costs Of School Policing, Maryam Ahranjani, Natalie Saing

Faculty Scholarship

Abstract

Responding to fears of violence and liability on K-12 campuses, local school boards and superintendents have made on-site or embedded school police omnipresent in American public schools. Yet, very little attention is paid to the many costs associated with their presence. When situating law enforcement’s presence squarely in the racist history of policing and school policing, the juxtaposition with the civic purpose of public education reveals significant constitutional costs. This Article builds on existing scholarship by bringing attention to the conflict between the First, Fourth, Fifth, Eighth, and Fourteenth Amendments and the dimensions of embedded school police. Ultimately, schools …

Prometheus Bound By Peter Paul Rubens And Frans Snyders: Psychological And Physical Punishment, Lauren E. Reddington

2023 Award Winners

No abstract provided.

Main Concept, Sequencing, & Story Grammar (Mssg) Analyses Of The Cinderella Story In Primary Progressive Aphasia, Janet Adams, Sarah Grace Dalton, H Isabel Hubbard, Erika Partridge, John Adair, Janice Knoefel, Elizabeth Ott, Gary Rosenberg, Jessica D. Richardson

Brain & Behavioral Health Research Day

Primary Progressive Aphasia (PPA) is a neurodegenerative condition where speech and language deficits are the initial and most prominent symptoms. There are three recognized PPA variants with distinctive speech-language features, areas of atrophy, and underlying neuropathology. In the early stages of all variants, language symptoms may be very mild, such that they can only be seen on more complex and generative tasks (e.g., discourse production) rather than naming, repetition, etc. Previous work by Dalton et al. (2020) focused on MCA and Core Lexicon demonstrated that, compared to HCs, PWPPAs produced discourse that was less informative and efficient, with fewer typical …

2022 Location Report, The Office Of Program Evaluation, Education And Research At The University Of New Mexico (Unm) School Of Medicine

University of New Mexico School of Medicine Location Report

No abstract provided.

Unm Pathology Pathfinder Winter 2022, Unm Department Of Pathology

Newsletters

No abstract provided.

Psychedelic Therapies At The Crossroads Of Trauma And Substance Use: Historical Perspectives And Future Directions, Taking A Lead From New Mexico, Snehal R. Bhatt, Maya Armstrong, Tassy Parker, Marcello Maviglia, Rebecca Kass, Lawrence Leeman, Paul Romo, Douglas Ziedonis

Family and Community Medicine Research and Scholarship

Post-traumatic stress disorder (PTSD), a common condition with potentially devastating individual, family, and societal consequences, is highly associated with substance use disorders (SUDs). The association between PTSD and SUD is complex and may involve adverse childhood experiences (ACEs), historical and multi-generational traumas, and social determinants of health as well as cultural and spiritual contexts. Current psychosocial and pharmacological treatments for PTSD are only modestly effective, and there is a need for more research on therapeutic interventions for co-occurring PTSD and SUD, including whether to provide integrated or sequential treatments. There is a current resurgence of interest in psychedelics as potential …

Issue No. 116: Spring 2022

La Crónica de Nuevo México

2 A Letter from the President

3 White Sands Missile Range Museum evolves by Darren Court

7 Creating a Historic Site: Fort Selden by Alexandra McKinney

12 A Man for his Time: James Silas Calhoun by Sherry Robinson

18 Nancy Owen Lewis: A loss to HSNM by Susan M. Berry

19 New Books

Examining Mediating Effects Of Self-Efficacy On Alcohol And Drug Use Outcomes In Mindfulness-Based Relapse Prevention And Cognitive-Behavioral Relapse Prevention, David I.K Moniz-Lewis, Elena R. Stein, Sarah Bowen, Katie Witkiewitz

Brain & Behavioral Health Research Day

Purpose: Self-efficacy has been shown as an important predictor of outcomes following substance use disorder (SUD) treatment, evidencing it as a potential mechanism of behavior change. This secondary analysis examined the mediating effects of self-efficacy within Mindfulness-Based Relapse Prevention (MBRP) and standard Relapse Prevention (RP) for individuals with SUD in an aftercare setting. We hypothesized that post-treatment self-efficacy would mediate the association between treatment condition and 12-month substance use outcomes.

Methods: Participants were 286 individuals recruited following in/outpatient treatment and were randomized to either MBRP, RP, or treatment as usual (TAU). Participants completed the Drug Taking Confidence Questionnaire (DTQC-8) to …

Investigating Mechanistic Pathways Involved In Neuroimmune Dysregulation And Neuropathic Pain Susceptibility Due To Prenatal Alcohol Exposure, Ariana Pritha, Joshua J. Sanchez, Jacob E. Sanchez, Suzy Davies, Daniel D. Savage, Nikolaos Mellios, Shahani Noor, Erin D. Milligan

Brain & Behavioral Health Research Day

Neuropathic pain is a chronic pain condition resulting from damaged peripheral nerves that induces allodynia (pathological touch sensitivity). Our previous studies suggest that prenatal alcohol exposure (PAE) is a risk factor for allodynia. In contrast to control rats, adult PAE rats with minimal nerve injury develop allodynia. Nerve-injured PAE rats display heightened peripheral and central nervous system (CNS) immune cell-derived proinflammatory cytokine production that consequently results in allodynia. This suggests that PAE dysregulates peripheral immune and CNS glial cell function to over-respond to subtle immune challenges leading to allodynia. However, gene expression profiles underlying dysregulated neuroimmune activity due to PAE …

Being Okay With Not Being Okay: Thinking About Mental Health, Caitlin Everhart, Trish Marquez, Jeanette Ortiz

Brain & Behavioral Health Research Day

Thinking About Mental Health is an initiative for youths and young adults which started at Explora during the COVID-19 pandemic. The initial goals of the program were to provide a series of videos with mental health professionals answering questions directly asked by the young adults employed at Explora, as well as an informative, accessible website with further reading and resources. Following these conversations, we evaluated what the teens told us by creating themes around topics. We used these themes to craft questions that would address the majority of the concerns posed by the teens in a concise manner. Since maintaining …

Effect Of The Covid-19 Pandemic On Real-Time Physiologic Outcomes Assessed By Wearable Electronics In Pregnant And Postpartum Women With Intersecting Vulnerabilities, Xingya Ma, Sharon Ruyak, Stephanie Chambers, Dominique Rodriguez, Laura Stacy, Melissa Roberts, Richard De La Garza, Conrad Chao, Ludmila N. Bakhireva

Brain & Behavioral Health Research Day

Purpose: COVID-19 has increased risk of mental health disorders and substance use in vulnerable populations, such as pregnant women and women with young children. This study characterizes the effect of the COVID-19 pandemic on real-time physiologic outcomes, assessed as heart rate variability (HRV), in pregnant and postpartum women with intersecting vulnerabilities.

Methods: A subset of pregnant and postpartum women were identified from the ENRICH-2 prospective cohort study. Women were recruited and classified into alcohol-exposed and control groups based on repeated self-report measures and comprehensive ethanol biomarker panels. HRV was captured continuously via wearable electronics along with the administration of mobile …

Noninvasive Vagus Nerve Stimulation Reduces Brain Lesion Volume In A Rat Model Of Traumatic Brain Injury, Afshin A. Divani, Erik Taylor, Hafiz Abdullha Ikram, Pascal Salazar, Yirong Yang, Karen Santacruz, Onamma A. Edeh, Denis E. Bragin

Brain & Behavioral Health Research Day

Background: Traumatic brain injury (TBI) continues to be a major cause of death and disability. Vagus nerve stimulation (VNS) has been shown to reduce proinflammatory responses in TBI models. We assessed the effect of a non-invasive VNS (nVNS) on reducing the lesion volume in a rat model of TBI.

Methods: TBI was induced using a standard CCI (Impact one, Leica) model. Rats were randomized into three groups: TBI control, TBI treated with five 2-min nVNS stimulations, and TBI treated with five 2x2-min nVNS stimulations using the gammaCore device was initiated 30 minutes post-TBI (10 minutes interval between each stimulation). MRI …

Understanding Mild Cognitive Impairment, Ron Epps, Chris Chaffin, Tim Sheahan, Craig Coleman

Brain & Behavioral Health Research Day

The Alzheimer’s Association, New Mexico Chapter is a nonprofit that provides support, fundraising and advocacy on behalf of the 43,000 New Mexicans with Alzheimer’s disease and their 85,000 unpaid family caregivers. Our Chapter is a community-based, volunteer-driven 501(c) (3) nonprofit that maximizes collaboration with other public and private agencies; and relies primarily upon funding from private individuals, foundations and corporations to meet the needs created by the growing Alzheimer’s epidemic. Our vision: a world without Alzheimer's and all other dementia. Our mission: The Alzheimer's Association leads the way to end Alzheimer's and all other dementia — by accelerating global research, …

Impact Of Isolation During The Covid-19 Pandemic On Non-Motor Symptoms Of Parkinson’S Disease: A Pmd Alliance Survey, Neal Hermanowicz, Maria Cristina Ospina, Yasar Torres-Yaghi, Sherrie Gould, Kelly Papesh, Jason Rivera, Susan Miller, Sarah Jones, Kelli Musick, Damian May

Brain & Behavioral Health Research Day

Introduction: Social isolation impairs physical and mental health, particularly among the elderly. As Parkinson’s disease (PD) usually affects the elderly, we hypothesized that social isolation during the COVID-19 pandemic could exacerbate non-motor symptoms of PD. This survey aimed to assess the impact of social isolation on self- or proxy-reported symptoms PD during the COVID-19 pandemic.

Methods: The survey was distributed online between 01/06/21 and 02/27/21 among 7,109 subscribers of the Parkinson and Movement Disorders Alliance (PMD Alliance) newsletter. It was open only to people with PD (PwP) and Care Partners (CP, defined as main caregivers of PwP, and serving as …

The Influence Of Maternal-Child Interactions During Early Child Development And The Impact On Anterior Cingulate Cortex Volumes, Sofia Markee, Dawn Novak, John Philips, Kati N. Baillie, Tiffany Emery, Jean Lowe

Brain & Behavioral Health Research Day

Background: Studies investigating differences in regional brain volumes in children during early childhood are limited. Many theories suggest the anterior cingulate cortex (ACC) is at the center of the brain’s self-regulatory system playing a key role in learning and emotion. Our aim is to investigate the volume of the ACC identified with MRI and developmental outcomes in children at 18 months. We hypothesize the volume of the ACC will be larger in children who received more positive directing behaviors from their mothers during play and ACC volumes will be larger in children with higher cognitive and language scores as measured …

Third Trimester-Equivalent Ethanol Exposure Decreases Neuronal Numbers In The Antero-Ventral And Reticular Nuclei Of The Thalamus Of Adolescent Male Mice, Stephanie Mayfield, G Jill Chavez, Clark Bird, C Fernando Valenzuela

Brain & Behavioral Health Research Day

Fetal alcohol exposure is a pervasive cause of intellectual disability. The range of effects caused by prenatal ethanol exposure are grouped under the umbrella term, Fetal Alcohol Spectrum Disorders (FASDs). Exposure to alcohol during any period of pregnancy can damage the fetal brain, including the last trimester of pregnancy, where the brain growth spurt takes place. Ethanol exposure during late pregnancy produces learning and memory deficits that can last into adulthood. Studies suggest that these deficits may be a consequence of damage to the posterior limbic memory system. This system includes specialized neuronal populations in several connected regions: the subiculum, …

Unm Health Sciences Center Data Book 2021-22, University Of New Mexico - Health Sciences Center

Health Sciences Center Databook (1990-ongoing)

No abstract provided.