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The Complexity Of American Federalism, Christian G. Fritz Aug 2024

The Complexity Of American Federalism, Christian G. Fritz

Faculty Scholarship

For the Balkinization Symposium on Alison L. LaCroix, The Interbellum Constitution: Union, Commerce, and Slavery in the Age of Federalisms (Yale University Press, 2024).

Alison LaCroix’s insightful new book, The Interbellum Constitution, builds on an often-overlooked fact: that Americans living before the Civil War did not know they were part of an “antebellum” period. That oversight has contributed to a conventional narrative of constitutional history and doctrine during the first half of the nineteenth-century that tends to read that history and doctrine backwards through the lens of a war that contemporaries did not know would define them. From this …


The Role Of Elevation In The Migration, Physiology, And Genomic Diversification Of Birds, Jessie L. Williamson Aug 2024

The Role Of Elevation In The Migration, Physiology, And Genomic Diversification Of Birds, Jessie L. Williamson

Biology ETDs

Elevational gradients cause profound eco-climatic variation across short distances. Partial pressure of oxygen (PO2) is a severe challenge that organisms face at high elevations; due partly to specialization on PO2, most Neotropical bird species have narrow elevational ranges. However, a small fraction are elevational generalists that span sea level to high elevations, and a subset undertake extreme migratory journeys from low to high elevations biannually. My dissertation combines diverse approaches across levels of biological organization to understand how elevation impacts the ecology, evolution, physiology, and migration of montane birds. I examined ‘extreme’ elevational …


Analyzing Interdisciplinary Education In General Medicine Using Smarandache's Multivalued Logic Hypothesis Theory And Plithogenic Probability, Dolores Hernandez De La Cantera, Rosangela Caicedo Quiroz, Mairim Lago Queija, Jeanntte Rodriguez Gonzalez, Maikel Y. Leyva Vazquez Aug 2024

Analyzing Interdisciplinary Education In General Medicine Using Smarandache's Multivalued Logic Hypothesis Theory And Plithogenic Probability, Dolores Hernandez De La Cantera, Rosangela Caicedo Quiroz, Mairim Lago Queija, Jeanntte Rodriguez Gonzalez, Maikel Y. Leyva Vazquez

Neutrosophic Sets and Systems

Smarandache extended the concept of falsifiability to include hypotheses that involve multiple values. Smarandache's extension of classical logic introduces Partial Falsifiability within multi-valued logic, which allows for the inclusion of partial truth values, uncertainties, and false values, unlike traditional falsifiability which only classifies hypotheses as completely true or false. Using this approach this study investigates specifically the concept of interdisciplinarity in the field of integral general medicine, with a specific emphasis on the integration of nursing procedures. The method employs sentiment analysis of scientific questions using the Consensus tool and plithogenic statistics to assess complex hypotheses. The findings indicate that …


Teachers’ Self-Reported Practices Of Teaching Academic Writing In Pakistani Universities, Hafiz Yar Aug 2024

Teachers’ Self-Reported Practices Of Teaching Academic Writing In Pakistani Universities, Hafiz Yar

Language, Literacy, and Sociocultural Studies ETDs

This study has explored teachers’ self-reported practices of teaching academic writing in Pakistani universities. The English language based developmental literacy courses in Pakistani undergraduate degrees are offered as part of the curricula rather than through specialized language centers. The three-course progression of developmental English literacy in Pakistani undergraduate curricula aims to develop academic writing proficiency besides effective business communication and technical report writing skills.

This study has used generic qualitative research methodology (Caelli et al., 2003; Kahlke, 2014; Kostere & Kostere, 2021), snowball sampling for participant recruitment, and a combination of survey and one-to-one semi structured interviews for data collection. …


An Adaptive Neutrosophic Large Neighborhood Search And Its Application, Jun Jiang, Fangwei Zhang, Yiying Pan, Rui Wang, Zhu Han Aug 2024

An Adaptive Neutrosophic Large Neighborhood Search And Its Application, Jun Jiang, Fangwei Zhang, Yiying Pan, Rui Wang, Zhu Han

Neutrosophic Sets and Systems

the improvement degree in the new solution, which causes fuzziness and uncertainty in the operator score. To solve the aforementioned problem, the main innovation of this study is to propose an adaptive neutrosophic large neighborhood search (ANLNS). Specifically, the main work is as follows. Firstly, the number of times each operator scores are quantified by constructing NSs, thereby analyzing algorithm performance and preventing the idealization of scores. Secondly, a novel neutrosophic utility function and score function are proposed to assign an appropriate score for the operator within a reasonable interval. Finally, the effectiveness and robustness of the proposed ANLNS is …


Understanding Longitudinal Top-Down Cracking To Enhance Asphalt Mix Design, Md Mehedi Hasan Jul 2024

Understanding Longitudinal Top-Down Cracking To Enhance Asphalt Mix Design, Md Mehedi Hasan

Civil Engineering ETDs

This study focuses on developing a deformation rate-dependent bilinear constitutive equation for cohesive zone modeling of asphalt concrete's fracture process zone to accurately predict the longitudinal top-down crack initiation and propagation. A mathematical model has been developed for the AC materials' deformation rate-dependent cohesive zone fracture characteristics and incorporated into the ABAQUS software as a customized user element subroutine (UEL). The developed model has been validated by comparing the simulation results with the laboratory test results, which show good agreement with the results. In addition, an enhanced asphalt mix design approach, referred to as SP5, has been developed to mitigate …


Negation In Dene Languages, Cormac League Jul 2024

Negation In Dene Languages, Cormac League

Linguistics ETDs

This thesis uses a typologically informed approach to investigate the strategies used for negation in Dene languages. This study illuminates aspects of the development of negation by examining the complex interplay between the lexical forms and morphosyntactic strategies employed to encode negative polarity in declarative and prohibitive constructions. The theoretical frameworks of the Jespersen Cycle and the Negative Existential Cycle are utilized to discuss negators in relation to their possible origins. Particular attention is given to the Pacific Coast and Southern Dene languages to propose an origin for the bipartite negation strategies used in the later. Through examination of synchronic …


“How I Dress Is No One’S Business!”: Fashion As A Subversive Language Of Resistance Among Female Christian Celebrities In Ghana, Amanda E. Gyesi Jul 2024

“How I Dress Is No One’S Business!”: Fashion As A Subversive Language Of Resistance Among Female Christian Celebrities In Ghana, Amanda E. Gyesi

Communication ETDs

Influenced by burgeoning literature on feminism and feminist theories, specifically within the African context, I analyze the intersection of religion and celebrity culture among a select group of women in Ghana. Using the African feminist critical discourse analysis, guided by Stuart Hall’s encoding and decoding model, this research examines how female Christian celebrities in Ghana enact resistance, project their agency, and shape their identities through their fashion statements and sartorial choices, hence contributing to the broader discourse on fashion communication among religious women.

Through a critical analysis of Instagram comments and YouTube interview transcripts, I argue that fashion communication among …


(Dis)Connecting Incommensurable Relationalities: Aesthetics Of Desirable Citizenship & Interethnic Solidarity In Vietnamese/American Diasporic Media, Anh A. T. Nguyen Jul 2024

(Dis)Connecting Incommensurable Relationalities: Aesthetics Of Desirable Citizenship & Interethnic Solidarity In Vietnamese/American Diasporic Media, Anh A. T. Nguyen

Communication ETDs

Employing critical diasporic rhetoric to articulate the pull and push glimmer of essentialist and nationalistic agendas of constructing Vietnamese diasporic subjectivities, I elucidate the complicated structure of diasporic nationalism that gives shape to ambiguities, paradoxes, and contradictions of Vietnamese diasporic withdrawal and regroupment in interethnic politics. Through three case studies explicating Vietnamese diasporic responses to the Chinese virus rhetorics, the appearance of the South Vietnamese flag on January 6 Capitol grounds, and the Atlanta shootings in Saigon Broadcasting Television Networks (SBTN), I highlight how Vietnamese diasporic authorities perform and enact citizenships of becoming desirable, which elevates oppressive forces of ideological …


Grievability And The Contingency Of Life Value In Twenty-First-Century Science Fiction, Emily A. Reiff Jul 2024

Grievability And The Contingency Of Life Value In Twenty-First-Century Science Fiction, Emily A. Reiff

English Language and Literature ETDs

Using Judith Butler’s framework of grievability, this dissertation explores twenty-first-century science fiction by British, Irish, and Caribbean authors whose novels grapple with legacies of colonialism and imperialism that relied on dehumanization and subjugation. Beginning with Sarah Maria Griffin’s Spare and Found Parts (2016), chapter one explores neocolonial rationales—purportedly based on health—which recreate colonial divisions of class and labor and enforce systems of diminishing grievability in a post-apocalyptic Irish context. Chapter two contends that Kazuo Ishiguro’s Klara and the Sun (2021) illustrates the danger inherent to value systems that center “normative” embodiment in worlds that reconfigure hypercapacitated human beings as the …


Host-Microbiome Interactions In The Teleost Brain, Amir Mani Varnoosfaderani Jul 2024

Host-Microbiome Interactions In The Teleost Brain, Amir Mani Varnoosfaderani

Biology ETDs

This dissertation investigates host-microbial interactions within the teleost brain, previously considered sterile. Reviewing current literature highlights significant gaps in understanding teleost brain immunity, despite prevalent neurotropic diseases. We mapped the immune profiles of rainbow trout brains and meninges, revealing the olfactory bulbs as the immune effector part of the brain and the optic tectum as a nod2 expression hub. High il6 and il10 levels were noted in the telencephalon. A persistent bacterial community within healthy salmonid brains shares diversity with gut and blood microbiota. Brain bacterial isolates exhibit genomic signatures for brain colonization and polyamine biosynthesis. The microbiota shifts across …


A Usage-Based Account Of Ongoing Structural Changes In Sanapaná: Grammar Sketch And Case Studies, Jens E. L. Van Gysel Jul 2024

A Usage-Based Account Of Ongoing Structural Changes In Sanapaná: Grammar Sketch And Case Studies, Jens E. L. Van Gysel

Linguistics ETDs

This dissertation presents three case studies on sociolinguistic variation in Sanapaná, an Enlhet-Enenlhet language spoken by around 1000 people in Paraguay. It investigates the impact of the process of language shift towards Paraguayan Guarani and Spanish that Sanapaná is undergoing. Specifically, it attempts to disentangle the effects of speakers’ multilingualism in Spanish and/or Guarani, their frequency of use of Sanapaná, and structural factors internal to Sanapaná on phonetic, morphological, and syntactic variation. It finds that Spanish/Guarani proficiency is correlated with L1-to-L2 convergence in Sanapaná vowel productions and use of different motion framing strategies, while frequency of Sanapaná usage is a …


Agave, Tamarindo Y Jamaica: Testimonios And Movements Of Jotería Rural And Afro-Jotería Rural From The Ranchos And Pueblos Of Rural Southern Mexico, Luis Oswaldo Esparza Jul 2024

Agave, Tamarindo Y Jamaica: Testimonios And Movements Of Jotería Rural And Afro-Jotería Rural From The Ranchos And Pueblos Of Rural Southern Mexico, Luis Oswaldo Esparza

Chicana and Chicano Studies ETDs

This project aims to celebrate and honor resistance strategies by Jotería Rural and Afro-Jotería Rural, who have originally inherited, implemented, and recreated life-affirming survival mechanisms of joy and survival. I accomplished this using a Nagualing Jotería methodologies that humanizes participants by treating their testimonials as legitimate community-based knowledge (Fierros & Delgado-Bernal, 2016). Together, my contributors and I constructed a list of resistance strategies as they tied their experiences in relation to and against repressive colonial rhetoric that continues to be re-articulated in the rural.


Exploration Of Semiconductor Gain Medium, Resonator, Pump, And Frequency Stabilization For Laser Guide Star Applications, Mingyang Zhang Jul 2024

Exploration Of Semiconductor Gain Medium, Resonator, Pump, And Frequency Stabilization For Laser Guide Star Applications, Mingyang Zhang

Optical Science and Engineering ETDs

Laser Guide Star (LGS) systems are essential for adaptive optics in ground-based astronomical observation. This dissertation demonstrates the feasibility of semiconductor-based LGS systems using the membrane external-cavity surface-emitting laser (MECSEL) platform, employing multiple quantum wells. Various laser cavity configurations were analyzed through simulations and experiments. The in-well pumping method was explored to reduce the quantum defect and address thermal limitations. Multi-pass pumping schemes were designed with Zemax modeling and demonstrated experimentally. To simplify multi-pass pumping, the hybrid-MECSEL (H-MECSEL) design was introduced. COMSOL modeling studied thermal management and thermal lensing effect.

The H-MECSEL achieved approximately 30 W of output power at …


Media Road To Violence: A Process Of Racialization Of Rohingya Ethnic Minority, Md Didarul Islam Jul 2024

Media Road To Violence: A Process Of Racialization Of Rohingya Ethnic Minority, Md Didarul Islam

Communication ETDs

ABSTRACT

This dissertation examines how ideologically loaded news media representations advanced the complex and ambiguous process of racialization of the Rohingyas, an ethnic Muslim minority in Myanmar. This study first interrogates the dominant patterns in news sourcing and thematic emphasis in the coverage of Rohingya; secondly, it sheds light on how these representations contribute to reproducing dominant ideologies and power relations. I selected two English-language newspapers published in Myanmar: The Global New Light of Myanmar and the Myanmar Times. I applied the notions of media representation (Hall, 1997), ideology (Althusser, 2007), and racialization (Garner & Selod, 2015) as the central …


Wars Of Position: The Construction Of An Antifascist Public Sphere In Spain, 1931-1939, Carter David Barnwell Jul 2024

Wars Of Position: The Construction Of An Antifascist Public Sphere In Spain, 1931-1939, Carter David Barnwell

History ETDs

This dissertation explores antifascist culture in Spain during the decade of the 1930s, and the ways in which it was developed and disseminated by a host of intellectuals and activists under the Second Republic from 1931-1939. In considering parliamentary addresses, performative speech acts, election propaganda, public demonstrations, newspaper and journal articles, multi-media art, and photographs, the study demonstrates how political and cultural leaders came to define and understand “antifascism” and what they hoped to achieve by embracing this term. An antifascist culture developed amongst broad elements of the Spanish political left and center under the Second Republic, which came to …


Chemical And Morphological Characterization Of Airborne Particulate Matter At The Jackpile-Paguate Mine, Pueblo Of Laguna, New Mexico: Implications For Potential Metals Exposure, Andreanna C. Roros Jul 2024

Chemical And Morphological Characterization Of Airborne Particulate Matter At The Jackpile-Paguate Mine, Pueblo Of Laguna, New Mexico: Implications For Potential Metals Exposure, Andreanna C. Roros

Earth and Planetary Sciences ETDs

The inhalation of windblown particulate matter (PM) derived from abandoned uranium mines (AUMs) is a potential environmental health risk to Native American communities that live in proximity to these sites. However, the aeolian transport of metal-bearing PM from AUMs, as a potential exposure pathway, has not been investigated in any detail. In this study, we sampled airborne particulate matter within the Jackpile Mine located on the lands of the Pueblo of Laguna, New Mexico using passive sampling methods to understand the characteristics of dust within the mine site. The objective was to determine the elemental concentrations, mineralogy, and morphology of …


The Borders Of Embodiment: Transgression, Transformation, And Corporeality In Chicanx Speculative Fiction, Chrysta Carson Wilson Jul 2024

The Borders Of Embodiment: Transgression, Transformation, And Corporeality In Chicanx Speculative Fiction, Chrysta Carson Wilson

English Language and Literature ETDs

This dissertation develops a clearer vision of Chicanx Speculative Fiction (SF) as its own genre anchored to the experiences and histories of the Chicanx community, with a particular interest in the avenues through which race and gender shape the experience of embodiment. SF resists hegemonic narratives that justify racial hierarchies and reveals both the cultural and concrete pressures exerted on Chicanx bodies in the United States as a minoritized and often exploited community. Furthermore, my analysis illustrates that Chicanx writers utilize elements of SF to defamiliarize traditional notions of race, class, and nationality. Through the use of defamiliarization, Chicanx SF …


A Stable Isotope Study To Investigate Water Movement In The Los Lagos Region Of Southern Chile, Kritan Subedi Jul 2024

A Stable Isotope Study To Investigate Water Movement In The Los Lagos Region Of Southern Chile, Kritan Subedi

Civil Engineering ETDs

The Los Lagos region in southern Chile, located in northwest Patagonia, features rain-fed agricultural lands, glacial lakes, forests, farmlands, and volcanic soils. This study investigates water movement within a micro-basin using stable isotope analysis and hydrological modeling over eight weeks. It aims to develop a conceptual model of water movement by elucidating interactions between precipitation, soil water, and streamflow. Findings highlight the critical role of deeper soil layers in sustaining streamflow during dry spells and indicate that soil acts as a buffer, maintaining hydrological continuity despite variable precipitation. Improved understanding of these dynamics can inform watershed management and water resource …


Optical Responses Of Hybrid Electromagnetic Nanostructures, Dominic Bosomtwi Jul 2024

Optical Responses Of Hybrid Electromagnetic Nanostructures, Dominic Bosomtwi

Optical Science and Engineering ETDs

Fano resonances result from the interference between a broad background and a narrow state, producing asymmetric scattering profiles. Under specific conditions, destructive interference collapses the Fano resonance width, leading to bound states in the continuum (BICs) that localize light within a nanostructure while maintaining an infinitely high-quality factor (Q-factor).

This dissertation explores the design of nanostructures with multilayer hybrid plasmonic-dielectric metasurfaces using full-wave numerical simulations, facilitating multiple Fano resonances and BICs. By adjusting nanoantenna dimensions, multiple modes are excited at plasmonic-dielectric interfaces, leading to strong interactions and hybridization of energy levels, manifested as Rabi splitting.

These findings enable advancements in …


Embracing Social-Emotional Learning And Nurturing Character: A Systematic Review Of Intersectional-Eq Strategies For Educational Leaders, Leticia G. Candelaria-Archuleta Jul 2024

Embracing Social-Emotional Learning And Nurturing Character: A Systematic Review Of Intersectional-Eq Strategies For Educational Leaders, Leticia G. Candelaria-Archuleta

Teacher Education, Educational Leadership & Policy ETDs

The COVID-19 pandemic expanded education beyond traditional academics, highlighting the importance of social-emotional learning (SEL) and character education (CE) for positive youth outcomes. This study examined the role of educational leadership in implementing SEL and CE in schools through a term coined Intersectional-EQ. This study centered on a cutting-edge approach using grey literature, specifically doctoral dissertations, to capture current trends in unprecedented times. A systematic review through Covidence, guided by PRISMA and PICO frameworks, was conducted. Findings highlight the impact of leadership on SEL and CE through an intersectional lens. Future work is aimed to support holistic student growth by …


Transnational(Izing) African Communication: A Post-/Decolonial Approach To Nollywood And Globalization, Tomide Oloruntobi Jul 2024

Transnational(Izing) African Communication: A Post-/Decolonial Approach To Nollywood And Globalization, Tomide Oloruntobi

Communication ETDs

In this dissertation, I examine culture and communication in transnational Nigeria, focusing on Nollywood and its industrial politics. Through a critical ethnographic examination of Nollywood’s reception among global and transnational audiences, I critique the evolving patterns of difference, power, and politics informing production, distribution, consumption, and performance/communication of otherness. With four composite dimensions of decoloniality: structural, epistemic, personal, and relational as theoretical foundation, I analyzed observations and interviews with 21 transnational Nigerians, online focus group discussions, user reviews, movies/series, and blogposts. I discuss the emergent themes of coloniality of space, mobility, and culture; re-making of racial otherness and hetero-patriarchy/normativity; cultural …


Sand, Ice, And X-Rays: Developing Xct Methods For Frozen Samples And Refining Siliciclastic Facies Models For Perennially Ice-Covered Lakes, Utilizing Cores From Lake Fryxell, Mcmurdo Dry Valleys, Antarctica, Holly M. Levett Jul 2024

Sand, Ice, And X-Rays: Developing Xct Methods For Frozen Samples And Refining Siliciclastic Facies Models For Perennially Ice-Covered Lakes, Utilizing Cores From Lake Fryxell, Mcmurdo Dry Valleys, Antarctica, Holly M. Levett

Earth and Planetary Sciences ETDs

Sedimentation in perennially ice-covered lakes (PICLs) is proposed to be bi-modal, with mud deposited by stream inflow and sand deposited on the ice cover by aeolian processes and then melting through by absorption of solar radiation. Here, we consider Lake Fryxell, a PICL in the McMurdo Dry Valleys, and several lake bed cores about 30 cm in length, to better understand PICL facies through time, using micro X-ray CT (XCT). Using XCT images along with sieve and laser granulometry data, we constrained the grain-size of PICL deposits to dominantly medium / fine sand with a coarse component. The presence of …


A Dream Deferred: Communism, Secession, And The Decline Of Hardrock Unionism, Dominic Alexander Treadwell Jul 2024

A Dream Deferred: Communism, Secession, And The Decline Of Hardrock Unionism, Dominic Alexander Treadwell

History ETDs

This thesis examines how the changing conditions after World War II impacted organized labor, focusing on secession movements within the International Union of Mine, Mill and Smelter Workers. Secessions in Connecticut and Alabama and the differing responses by the CIO Executive Board highlight how external pressures from postwar dynamics and increasing anticommunism undermined the left-liberal alliance in the Congress of Industrial Organizations. World War II increased labor’s reliance on government mediation, reducing the effectiveness of militant strategies. Following the war, assertive capital, restrictive labor legislation, the Cold War, and the rise in anti-Communism exacerbated tensions in the CIO, leading to …


Diagnostic Evaluation Of Dizziness In Obstetric Triage, Annslee J. Lowe, Anna Shields Jul 2024

Diagnostic Evaluation Of Dizziness In Obstetric Triage, Annslee J. Lowe, Anna Shields

InterProfessional Education Research and Scholarship

Dizziness is a non-specific term used to describe various sensations of spinning, disequilibrium, imbalance, or near-syncope. The differential diagnosis for this symptom is rather extensive and includes potentially dangerous etiologies, which contributes to the significance of diagnostic evaluation. Dizziness is a frequent concern prompting pregnant patients to seek medical care, and the hemodynamic changes that occur in pregnancy further complicate clinical assessment in obstetric (OB) triage. While often familiar with dizziness as a symptom of hypertensive disorders of pregnancy, many OB triage providers experience uncertainty in working up other causes of dizziness. Root causes for uncertainty and the potential for …


Diagnostic Evaluation Of Palpitations In Obstetric Triage, Annslee J. Lowe, Anna Shields Jul 2024

Diagnostic Evaluation Of Palpitations In Obstetric Triage, Annslee J. Lowe, Anna Shields

InterProfessional Education Research and Scholarship

Palpitations are a common reason for pregnant patients to pursue medical evaluation. The range of etiologies that can contribute to palpitations is broad and includes life-threatening causes, while the physiologic changes in systemic hemodynamics that occur in pregnancy add further complexity to medical decision making in obstetric (OB) triage. While the literature suggests that diagnostic evaluation of palpitations in pregnant patients does not meaningfully differ from that of non-pregnant patients, many OB triage providers experience uncertainty in working up palpitations in pregnancy. Within University of New Mexico Hospital (UNMH) OB Triage, underlying causes for uncertainty were assessed and found to …


Imperial Architecture And Absolute Chronology In The Inka State: The View From Northern Chile, Beau G. Murphy Jul 2024

Imperial Architecture And Absolute Chronology In The Inka State: The View From Northern Chile, Beau G. Murphy

Anthropology ETDs

Scholars often evaluate the political aspects of imperial architecture in terms of the symbolism of specific buildings, leaving a gap in our understanding of the political calculations of overall site layouts. This study of the architecture of the Inka provincial capital of Turi, located in the Atacama of northern Chile, identifies aspects of planning in the site’s layout that extend our knowledge of the use of architecture by past empires to communicate political messages. In so doing, the study addresses multi-scalar issues of a neglected Inka chronology, including the chronology of Turi itself, of Inka rule of the Upper Loa …


Topics In Wappo Phonology, Aaron W. Marks Jul 2024

Topics In Wappo Phonology, Aaron W. Marks

Linguistics ETDs

This work examines various topics in the phonology and phonetics of the Wappo language (ʔonaʔcáṭis), an Indigenous American language spoken in Northern California. Utilizing both published written sources and the large audio corpus of spoken Wappo compiled by linguist Jesse Sawyer and housed at the California Language Archive at UC Berkeley, this work addresses several fundamental questions in Wappo phonology, including phoneme inventory structure, phonotactics, phoneme frequency, phonetics and allophony, word-level prosody, morphophonemics, and a detailed discussion of the context of Wappo phonology within the California Linguistic Area, including the question of a localized linguistic sub-area around the …


Conserved Mechanisms Of Drug Induced Lifespan Extension In S. Cerevisiae And C. Elegans, Christine E. Robbins Jul 2024

Conserved Mechanisms Of Drug Induced Lifespan Extension In S. Cerevisiae And C. Elegans, Christine E. Robbins

Biomedical Sciences ETDs

Aging is a phenomenon that brings aches, pains and a risk of developing diseases. Many researchers have discovered pathways that regulate aging by altering gene expression. Understanding genetic regulation of aging is key but identifying drugs that target aging will result in translatable treatments. Additionally, understanding how drugs are interacting with our cells allows us to create targeted therapies. I study two types of drugs. First, tRNA synthetase inhibitors are a class of drugs that inhibit charging of tRNAs. I identified a mechanism of lifespan extension by upregulation of the conserved transcription factor, Gcn4 / Atf-4. Second, I found that …


On The Surface Topography Of Local Overheating And Plasma Formation Due To Initial Condition Perturbations Sourcing The Electrothermal Instability On High-Current-Density Conductors, Maren Whiting Hatch Jul 2024

On The Surface Topography Of Local Overheating And Plasma Formation Due To Initial Condition Perturbations Sourcing The Electrothermal Instability On High-Current-Density Conductors, Maren Whiting Hatch

Electrical and Computer Engineering ETDs

The electrothermal instability (ETI) is a Joule heating-driven instability that instigates runaway heating on conductors driven to high current density, altering the 3D evolution of the expansion and phase state. Most metals include complex distributions of imperfections (voids, resistive inclusions) which seed ETI. To simplify comparison with modeling and theory, experiments examined growth of ETI from various alloys of stainless steel as well as relatively void/inclusion free, 99.999% pure, diamond-turned, 1 mm-diameter aluminum rods. Aluminum surfaces included a variety of deliberately machined and well-characterized perturbations, including 10-micron-scale quasi-hemispherical voids, or “engineered” defects (ED), and sinusoidal patterns of varying wavelength and …