Digital Commons Network^™

Integrins As Therapeutic Targets For Sars-Cov-2, Timothy E. Gressett, Danielle Nader, Juan Pablo Robles, Tione Buranda, Steven W. Kerrigan, Gregory Bix

Pathology Research and Scholarship

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus of the genus Betacoronavirus. Its genome is composed of four structural proteins known as spike (S), envelope (E), membrane (M), and nucleocapsid (N), of which E, M, and N are integrated into the viral envelope. The S glycoprotein, which protrudes from the surface of mature virions as a spike, is essential for virus attachment, fusion, and entry into the host cell. While the relationship between the spike protein of SARS-CoV-2 and the angiotensin- converting enzyme 2 (ACE2) receptor has been readily established, the S1 subunit also …

The Giant Axon Of The Squid: A Simple System For Axonal Transport Studies, Joseph A. Degiorgis, Marcus Jang, Elaine L. Bearer

Pathology Research and Scholarship

The squid giant axon has a long history of being a superb experimental system in which to investigate a wide range of questions concerning intracellular transport. In this protocol we describe the method used for dissecting the axon to preserve its viability in vitro, and the technique for injecting exogenous materials into the living axon. Now that the squid genome is emerging, and the CRISPR/cas9 system has been successfully applied to knock-out squid genes, the giant axon will resume its place in the scientific pantheon of powerful experimental systems in which to address biological questions pertaining to all eukaryotes.

Cultural Identity Central To Native American Persistence In Science., Nizhoni Chow-Garcia, Naomi Lee, Vanessa Svihla, Claira Sohn, Scott Willie, Maija Holsti, Angela Wandinger-Ness

Pathology Research and Scholarship

Native Americans are the least represented population in science fields. In recent years, undergraduate and graduate level summer research programs that aimed to increase the number of Native Americans in science have made some progress. As new programs are designed, key characteristics that address science self-efficacy and science identity and provide supports for Native American students' commitment to a scientific career should be considered. In this study, we used sequential mixed methods to investigate the potential of culturally tailored internship programs on Native American persistence in science. We analyzed surveys (n = 47) and interviews (n = 4) …

Magnetic Microscopy And Search For Exotic Interaction Detection With Color Centers In Diamond, Nathaniel Ristoff

Physics & Astronomy ETDs

Nitrogen vacancy (NV) centers have been used extensively for the measurement of magnetic fields in applications of geology, biology, medicine, and fundamental physics. In regard to fundamental physics, NV centers offer a unique opportunity to test potential velocity dependant spin-spin interactions as well as velocity-spin interactions at the micron scale. In regards to magnetic materials, NV centers offer a platform to investigate magnetic properties of nanoparticles in an individual, but highly parallelized measurement. In this work, an experiment is proposed to measure a potential fundamental interaction between spins, mediated by an integer spin boson. These velocity dependent interactions will couple …

“Who Is Eating Whom?”: Wet Nursing And White Cannibalism In Brazil, Grace Sparapani

Hemisphere: Visual Cultures of the Americas

No abstract provided.

Collected Papers (On Various Scientific Topics), Volume Xiii, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

This thirteenth volume of Collected Papers is an eclectic tome of 88 papers in various fields of sciences, such as astronomy, biology, calculus, economics, education and administration, game theory, geometry, graph theory, information fusion, decision making, instantaneous physics, quantum physics, neutrosophic logic and set, non-Euclidean geometry, number theory, paradoxes, philosophy of science, scientific research methods, statistics, and others, structured in 17 chapters (Neutrosophic Theory and Applications; Neutrosophic Algebra; Fuzzy Soft Sets; Neutrosophic Sets; Hypersoft Sets; Neutrosophic Semigroups; Neutrosophic Graphs; Superhypergraphs; Plithogeny; Information Fusion; Statistics; Decision Making; Extenics; Instantaneous Physics; Paradoxism; Mathematica; Miscellanea), comprising 965 pages, published between 2005-2022 in different …

The Plight Of Western Rivers, W. Howard Brandenburg

Natural Resources Journal

My oil paintings weave a narrative about the human species. I am interested in the space where our proliferation infringes upon ecosystem function. I am fascinated in what makes our species so successful and what that success means for the balance of nature. My paintings often target concepts around environmental transformations attributed to human activities and economies. Visual art provides me the latitude and freedom to explore and communicate these concepts, using a visual language which conveys disparate perspectives; universally and individualistically.

This duality is what I strive for in my work; producing an image that not only speaks a …

Premature Grey Wolf Delisting, Dr. Edward A. Fitzgerald

Natural Resources Journal

On November 3, 2020 the U.S. Fish and Wildlife Service (“FWS”)1 issued “Removing the Gray Wolf (Canis Lupus) From the List of Endangered and Threatened Wildlife” (“Final Rule”) delisting the gray wolf in forty-eight states, except for the Mexican gray wolf in the Southwest.2 This Final Rule returned gray wolf management to the states. Wolf delisting was a last-minute gift from the Trump administration to conservative voters, particularly hunters, trappers, and livestock owners right before the November 2020 presidential election. Hunters and trappers view the wolf as a competitor for the game that they want to kill, while livestock owners …

Cancer Vaccines From Cryogenically Silicified Tumour Cells Functionalized With Pathogen-Associated Molecular Patterns, Jimin Guo, Henning De May, Stefan Franco, Achraf Noureddine, Lien Tang, C J. Brinker, Donna F. Kusewitt, Sarah F. Adams, Rita E. Serda

Pathology Research and Scholarship

The production of personalized cancer vaccines made from autologous tumour cells could benefit from mechanisms that enhance immunogenicity. Here we show that cancer vaccines can be made via the cryogenic silicification of tumour cells, which preserves tumour antigens within nanoscopic layers of silica, followed by the decoration of the silicified surface with pathogen-associated molecular patterns. These pathogen-mimicking cells activate dendritic cells and enhance the internalization, processing and presentation of tumour antigens to T cells. In syngeneic mice with high-grade ovarian cancer, a cell-line-based silicified cancer vaccine supported the polarization of CD4⁺ T cells towards the T-helper-1 phenotype in the …

Ulcerative Colitis: Novel Epithelial Insights Provided By Single Cell Rna Sequencing, Joao M. Serigado, Jennifer Foulke-Abel, William C. Hines, Joshua A. Hanson, Julie In, Olga Kovbasnjuk

Pathology Research and Scholarship

Ulcerative Colitis (UC) is a chronic inflammatory disease of the intestinal tract for which a definitive etiology is yet unknown. Both genetic and environmental factors have been implicated in the development of UC. Recently, single cell RNA sequencing (scRNA-seq) technology revealed cell subpopulations contributing to the pathogenesis of UC and brought new insight into the pathways that connect genome to pathology. This review describes key scRNA-seq findings in two major studies by Broad Institute and University of Oxford, investigating the transcriptomic landscape of epithelial cells in UC. We focus on five major findings: (1) the identification of BEST4 + cells, …

Creating A Quality Life For People With Brain Injuries Using Neuroplasticity, Mindfulness Meditation, Mindfulness-Based Stress Reduction, Ken Collins

Brain & Behavioral Health Research Day

Ken Collins has lived with his brain injury for 45 years and has worked with people with brain injuries since 1983. He is an advocate of developing home and community-based services for people with brain injuries. In 1986-88 he was a VISTA Volunteer and helped develop the first transitional living program for people with brain injuries in the U.S. Ken is currently employed as Executive Director, Hozho Center for Personal Enhancement in Gallup, New Mexico where he supervises staff and provides independent living services to Veterans, Navajo's and Zuni's with brain injuries in McKinley County.

A Short History Of Fuzzy, Intuitionistic Fuzzy, Neutrosophic And Plithogenic Sets, A. Rezaei, T. Oner, T. Katikan, Florentin Smarandache, N. Gandotra

Branch Mathematics and Statistics Faculty and Staff Publications

Recently, research on uncertainty modeling is progressing rapidly and many essential and breakthrough studies have already been done. There are various ways such as fuzzy, intuitionistic and neutrosophic sets to handle these uncertainties.

Although these concepts can handle incomplete information in various real-world issues, they cannot address all types of uncertainty such as indeterminate and inconsistent information. Also, plithogenic sets as a generalization of crisp, fuzzy, intuitionistic fuzzy, and neutrosophic sets, which is a set whose elements are characterized by many attributes’ values. In this paper, our aim is to demonstrate and review the history of fuzzy, intuitionistic and neutrosophic …

This Land Is Your Land: The Dark Canon Of The United States Supreme Court In Natural Resources Law, Oliver A. Houck

Natural Resources Journal

This article treats four Supreme Court opinions that have had a lasting impact, largely negative, on public lands and resources. They rest on highly selective statements of fact, and dubious footing with precedent and statutory law. As a quartet they make the protection of natural resources extremely difficult. Resources that, in law, belong to us all. The first case, Southern Utah Wilderness Association, opened up a designated Wilderness Area too off-road vehicle use, where these uses are explicitly prohibited by law. In this opinion Justice Scalia managed, inter alia, to turn congressionally-mandated management plans into (unenforceable) wish lists, and find …

More Than A Rake: Toward A Statutory Solution For Wildfire Threats To Department Of Defense Installations, Steven L. Spencer Ii Major

Natural Resources Journal

Over the past four decades, the average area annually burned in wildfires in the United States has roughly quadrupled. Larger, more powerful wildfires increasingly threaten inhabited areas as well as vital infrastructure, including many installations of the United States Armed Forces. This article first introduces readers to what wildfire is and the unique challenges it creates to the environment, health and, specifically, to the Department of Defense (DoD). Next, it discusses the dominant approaches to addressing the wildfire threat, prescribed fire and mechanical treatment. It then summarizes the primary laws, policies and partners involved in wildfire policy in the United …

New Development Of Neutrosophic Probability, Neutrosophic Statistics, Neutrosophic Algebraic Structures, And Neutrosophic Plithogenic Optimizations, Florentin Smarandache, Yanhui Guo

Branch Mathematics and Statistics Faculty and Staff Publications

This collective book presents state-of-the-art papers on new topics related to neutrosophic theories, such as neutrosophic algebraic structures, neutrosophic triplet algebraic structures, neutrosophic extended triplet algebraic structures, neutrosophic algebraic hyperstructures, neutrosophic triplet algebraic hyperstructures, neutrosophic n-ary algebraic structures, neutrosophic n-ary algebraic hyperstructures, refined neutrosophic algebraic structures, refined neutrosophic algebraic hyperstructures, quadruple neutrosophic algebraic structures, refined quadruple neutrosophic algebraic structures, neutrosophic image processing, neutrosophic image classification, neutrosophic computer vision, neutrosophic machine learning, neutrosophic artificial intelligence, neutrosophic data analytics, neutrosophic deep learning, and neutrosophic symmetry, as well as their applications in the real world.

Neutrosophic Statistics Is An Extension Of Interval Statistics, While Plithogenic Statistics Is The Most General Form Of Statistics (Third Version), Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

: In this paper we prove that Neutrosophic Statistics is an extension of the Interval Statistics, since it may deal with all types of indeterminacies (with respect to the data, inferential procedures, probability distributions, graphical representations, etc.), it allows the reduction of indeterminacy, and it uses the neutrosophic probability that is more general than imprecise and classical probabilities, and has more detailed corresponding probability density functions. While Interval Statistics only deals with indeterminacy that can be represented by intervals. And we respond to the arguments by Woodall et al. [1]. We show that not all indeterminacies (uncertainties) may be represented …

Analyzing The Sustainability Of Industry Affected In Covid-19 Pandemic Scenario Using Cosine Similarity Measure Under Svpns And Pnn Model, Priyanka Majumder, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

COVID-19 outbreak is a reminder of the fact that the pandemics have happened in the past and will also occur in the future. The COVID-19 not only has affected the economy; but also it has affected the livelihood, which leads to the changes in businesses. This study aims to identify the most significant indicator (or parameter) that impacts the sustainability of industries. The study should also develop a realtime monitoring system for the sustainability of industries affected by COVID 19. In this work, the Polynomial Neural Network (PNN) and cosine similarity measure under SVPNS (Single-Valued Pentapartitioned Neutrosophic Set) environment have …

Nidus Idearum. Scilogs, Viii: Painting By Numbers, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this eighth book of scilogs collected from my nest of ideas, one may find new and old questions and solutions, – in email messages to research colleagues, or replies, and personal notes handwritten on the planes to, and from international conferences, about all kind of topics, centered mostly on Paradoxism and Neutrosophy.

Exchanging ideas with: Robert Neil Boyd, Joseph Brenner, Ahmed Cevik, Victor Christianto, Adrian Curaj, Jean Dezert, Andrei-Lucian Drăgoi, Ervin Goldfain, Young Bae Jun, Yale Landsberg, Radu Munteanu, Paul Piștea, Viorel Roman, Ridvan Sahin, Said Broumi, Selcuk Topal, Eric W. Weisstein, Xiaohing Zhang.

Nidus Idearum. Scilogs, Ix: Neutrosophia Perennis, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this ninth book of scilogs collected from my nest of ideas, one may find new and old questions and solutions, – in email messages to research colleagues, or replies, and personal notes, some handwritten on the planes to, and from international conferences, about topics on Neutrosophy and its applications, such as: Neutrosophic Bipolar Set, Linguistic Neutrosophic Set, Neutrosophic Resonance Frequency, n-ary HyperAlgebra, n-ary NeutroHyperAlgebra, n-ary AntiHyperAlgebra, Plithogenic Crisp Graph, Plithogenic Fuzzy Graph, Plithogenic Intuitionistic Fuzzy Graph, Plithogenic Neutrosophic Graph, Plithogenic Real Number Graph, Plithogenic Complex Number Graph, Plithogenic Neutrosophic Number Graph, and many more.

Exchanging ideas with: Tareq Al-Shami, …

A 385-Year Experiment To Erase A People: Intergenerational Acts Of Genocide Against The Narragansett Indian Tribe By The United States Of America And The State Of Rhode Island, Taylor A. Dumpson, Afro-Indigenous; Black, Narragansett, Nanticoke, And Mohawk Ancestry

Tribal Law Journal

Since Roger Williams’ arrival in Narragansett Territory in 1636, and his subsequent settlement of the Providence Plantations, the Narragansett Indian Tribe--the Indigenous people to this land--have faced a series of intergenerational atrocities, including attempted genocides. For generations, these heinous wrongs have not been corrected by state or federal courts, which have often compounded the harms against the Narragansett people. Although the American legal system has played a role in perpetuating the intergenerational harms experienced by the Narragansett people, these institutions also have the opportunity to be a part of the solution. The Article examines the existing domestic legal framework for …

Spatially Distributed Infection Increases Viral Load In A Computational Model Of Sars-Cov-2 Lung Infection, Melanie E. Moses, Steven Hofmeyr, Judy L. Cannon, Akil Andrews, Rebekah Gridley, Monica Hinga, Kirtus Leyba, Abigail Pribisova, Vanessa Surjadidjaja, Humayra Tasnim, Stephanie Forrest

Pathology Research and Scholarship

A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary dramatically across individuals. Because spatial-temporal dynamics of viral spread and immune response are challenging to study in vivo, we developed Spatial Immune Model of Coronavirus (SIMCoV), a scalable computational model that simulates hundreds of millions of lung cells, including respiratory epithelial cells and T cells. SIMCoV replicates viral growth dynamics observed in patients and shows how spatially dispersed infections can lead to increased viral loads. The model also shows how the timing and strength of the T cell response can affect viral persistence, oscillations, and control. …

Randomized Controlled Trial Of Early Outpatient Covid-19 Treatment With High-Titer Convalescent Plasma, David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Bryan Lau, Aarthi G G Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley, Evan M. Bloch, Valerie C. Cluzet

Pathology Research and Scholarship

BACKGROUND: The efficacy of polyclonal high titer convalescent plasma to prevent serious complications of COVID-19 in outpatients with recent onset of illness is uncertain.

METHODS: This multicenter, double-blind randomized controlled trial compared the efficacy and safety of SARS-CoV-2 high titer convalescent plasma to placebo control plasma in symptomatic adults ≥18 years positive for SARS-CoV-2 regardless of risk factors for disease progression or vaccine status. Participants with symptom onset within 8 days were enrolled, then transfused within the subsequent day. The measured primary outcome was COVID-19-related hospitalization within 28 days of plasma transfusion. The enrollment period was June 3, 2020 to …

Arginine-Rich Polypeptides Are Potent Inhibitors Of Human Papillomavirus Infection And Powerful Tools To Investigate Viral Attachment And Entry, Jesse Mckay Young

Biomedical Sciences ETDs

HPV is the most common sexually transmitted infection. It is estimated that 80% of sexually active adults will contract an HPV infection. Thus, there is a significant need for low-cost and easily distributable HPV antivirals that can be used alongside vaccines to combat infection. Herein I have identified protamine sulfate (PS) as a potent microbicide against HPV infection. PS was agnostic to genotype and efficacious pre and post HPV exposure. PS application topically reduced HPV internalization by altering epidermal growth factor receptor (EGFR) signaling and suppressed EGFR-stimulated HPV entry. Our preliminary data also suggest that heparin binding epidermal growth factor …

The Effect Of Ph On Organic Carbon Uptake And Biological Phosphorus Removal By Tetrasphaera Polyphosphate Accumulating Organisms, Derek Belka

Civil Engineering ETDs

Tetrasphaera polyphosphate accumulating organisms (PAOs) have been found in greater abundance and may remove more P in full-scale enhanced biological phosphorus removal (EBPR) water resource recovery facilities (WRRF) worldwide than the more extensively studied Accumulibacter PAO. Understanding the effect that environmental conditions, such as pH, have on Tetrasphaera metabolisms is critical to understanding EBPR WRRF process upsets, achieving consistent low effluent P concentrations, and formulating optimization strategies. The objective of this study was to determine pH effects over the range from 5.5 to 8.5 on anaerobic amino acid uptake, P release, and cation release in a Tetrasphaera-enriched culture from …

The Power Of Outdoor Learning Experiences: A Narrative Inquiry, Vincent M. Case

Language, Literacy, and Sociocultural Studies ETDs

Outdoor learning experiences offer schools an initial avenue to address global community issues, including climate change, natural resource depletion, disconnection from nature, and the current global coronavirus pandemic. This narrative inquiry study, grounded in the theoretical work of Vygotsky, Cajete, Brody, and Kahn, seeks to understand how children’s perceptions of their outdoor learning experiences provide insights into their learning processes. This study’s findings suggest that regardless of the location (mountains, home, school campuses, local natural areas), students say that they: experience positive affect and enjoyment; observe through their senses to explore, discover, inquire, change their behavior, and build deeper relationships …

Characterization Of Phase Behavior In Idp Solutions By Uv-Vis Spectrophotometry And Phase Volume Fraction Measurements In Capillaries, Qing Sun

Biomedical Engineering ETDs

Intrinsically disordered proteins (IDPs) play vital roles in cell signaling and regulation by changing conformation dynamically under various stimulus. Thus, it is crucial to understand their physical properties in vitro especially liquid-liquid phase separation (LLPS). Here, we first used UV-vis spectrophotometry to investigate two of IDPs' physical properties – transition temperature (Tt) and coacervate size. This deeper insight allows us to further understand the dynamics of phase growth. We then constructed a binodal curve in the phase diagram by measurement of volume ratios in phase separated IDP solution in glass capillaries.

Rapid Source To Sink Transition In A Mixed-Conifer Forest Following Stand-Replacing Fire, Ryan Matthew Schulze

Biology ETDs

Mixed-conifer forests play an important role in the Southwestern USA’s regional carbon cycle by sequestering and storing large amounts of atmospheric carbon onto the landscape. Despite this, little is known about how large, stand-replacing fire alters ecosystem carbon sink-source dynamics. In this study, we used eddy covariance to quantify how stand-replacing fire altered forest sink strength, and the sensitivity of carbon uptake to soil and atmospheric drought in a mixed-conifer forest located in The Valles Caldera National Preserve, NM. We found that the post-burn ecosystem returned to an annual net sink of carbon in the year immediately following the fire, …

Synthetic Aperture Optical Imaging Interferometric Microscopy With Improved Image Quality, Preyom K. Dey

Electrical and Computer Engineering ETDs

The resolution limit of optical microscopy can be extended by using Imaging Interferometric Microscopy (IIM), which uses a low numerical aperture (NA) objective lens to achieve resolution equivalent to that of a high-NA objective lens with multiple sub-images. Along with the resolution enhancement challenge, IIM often suffers from poor image quality. In this dissertation, several image quality improvement methods are proposed and verified with simulation and experimental results. Next, techniques to extend the resolution limit of IIM to ≤ 100nm using a low-NA objective lens are demonstrated. An experimental technique of using a grating coupler on …

Energetic Tradeoffs, Infection, And Immunity In Wild Chimpanzees Of Uganda And Tanzania, Sarah Renee Phillips

Anthropology ETDs

Infectious disease is a primary source of mortality for most mammal species, but scientists have little understanding of factors driving variation in infection and immunity between individuals, populations, and species in the wild. Life history theory provides an evolutionary framework for delineating distribution of available energy to competing physiological demands, including growth, reproduction, and maintenance. Early life reproduction should be favored over late life survival, but, in long-lived species, reproductive success is strongly tied to survival to old age. Slower pace of reproduction could allow investment in immunity, reducing risk of morbidity and mortality to infectious disease. Additionally, several host …

Moderate Prenatal Ethanol Exposure, Sex, And Housing Modify Spatial Navigation Behavior And Hippocampal Cell Firing In Adult Rodents, Christy Magcalas

Psychology ETDs

Prenatal alcohol exposure (PAE) is associated with structural and physiological changes that impact the central nervous system and can result in persistent negative consequences in a broad spectrum of cognitive and behavioral domains including deficits in spatial learning and memory and behavioral flexibility. The current study focuses on examining the behavioral and mechanistic consequences of PAE, sex and housing. Rats were tested in the Morris Water Task where they were trained to navigate to a goal location and tested in a pool shift manipulation. There were no significant differences between PAE treatment, sex, or housing groups during training, but there …