Digital Commons Network^™

Ngss-Based Constructivist Pedagogies: One Secondary Education Teacher’S Approach To Developing Student’S Science Identities, Massa Mafi

Teacher Education, Educational Leadership & Policy ETDs

This practitioner action research study explored features of NGSS-based pedagogies to improve secondary education student engagement, critical thinking, and collaborative problem-solving. It examined ways that constructivist pedagogies might encourage students to understand science by putting their skills and knowledge into practice as young engineers. The study involved 51 secondary education students from a large district in the southwest and focused on how NGSS inquiry-based learning can improve scientific understanding and skills within group work, the role that teacher support and modeling can play in learning, and how peer interactions can influence their scientific identities. Qualitative findings from teacher observations, classwork …

Identification Of Neuronal Injury And Survival Mrna Pathways After Spreading Depolarization, Michela Dell'orco, Lu Li, Jordan Weisend, Nora I. Perrone-Bizzozero, Lee Anna Cunningham, Russel Morton, Andrew P. Carlson, William Shuttleworth

Brain & Behavioral Health Research Day

Non-Expert Summary:

This study identified gene expression changes after repeated spreading depolarizations (SD) in healthy and injured brains. A large range of expression changes implicate SD in both deleterious and protective/adaptive changes. SDs are typically assumed to be purely damaging events, and thus increases seen in pathways related to neuronal growth and regeneration were surprising. Further studies of mechanisms underlying possible protective effects of SD could lead to new approaches to improve outcomes following stroke and trauma.

Abstract:

Spreading depolarization (SD) is a slowly propagating wave of profound depolarization that sweeps through cortical tissue. SD is not harmful to healthy …

Investigation Of Iron Homeostasis In Colon Tumorigenesis, Hyeoncheol Kim Ph.D.

Chemistry and Chemical Biology ETDs

Iron is essential part of the human metabolism. It is a catalytic co-factor for many proteins, but it generates harmful reactive oxygen species in human body. Also, many irons metabolic genes are changes in human cancer cells compared to normal cells, leading to iron accumulation in cancer cells especially in colorectal cancer.

Due to iron’s significant role in colorectal cancer promotion, much research is focused on its role in colorectal cancer genesis. But some important metabolic aspects are not fully addressed and researched. One key aspect of iron on colorectal cancer cell progression is hemin iron. Much research warned hemin …

A Framework For Promoting Diversity, Equity, And Inclusion In Genetics And Genomics Research, Timothy R. Rebbeck, John F P Bridges, Jennifer W. Mack, Stacy W. Gray, Jeffrey M. Trent, Suzanne George, Norah L. Crossnohere, Electra D. Paskett, Corrie A. Painter, Nikhil Wagle, Miria Kano, Patricia Nez Henderson, Jeffrey A. Henderson, Shiraz I. Mishra, Cheryl L. Willman, Andrew L. Sussman

Pediatrics Research and Scholarship

IMPORTANCE: Research into the genetic and genomic ("genomics") foundations of disease is central to our understanding of disease prevention, early detection, diagnostic accuracy, and therapeutic intervention. Inequitable participation in genomics research by historically excluded populations limits the ability to translate genomic knowledge to achieve health equity and ensure that findings are generalizable to diverse populations.

OBSERVATIONS: We propose a novel framework for promoting diversity, equity, and inclusion in genomics research. Building on principles of community-based participatory research and collective impact frameworks, the framework can guide our understanding of the social, cultural, health system, policy, community, and individual contexts in which …

Creating Lightbulb Moments: Developing Higher-Order Thinking In Family Law Classrooms Through Court Observations, Sonia Gipson Rankin

Faculty Scholarship

This article fills a critical gap in the family law literature by arguing that teaching doctrinal family law in conjunction with the application of established learning theory and pedagogy yields a deeper engagement with the subject matter and leads to more practice-ready lawyers. ABA Standards 301, 303, and 304 do not clearly articulate the distinction between experiential education and experiential learning; doctrinal law classrooms are often bereft of experiential learning activities. By incorporating active learning and inclusive pedagogy in the doctrinal classroom and following recommendations from the MacCrate Report and Family Law Education Reform Project, students will be better prepared …

Utility Of The Milan System For Reporting Salivary Gland Cytology, With Focus On The Incidence And Histologic Correlates Of Atypia Of Undetermined Significance (Aus) And Salivary Gland Neoplasm Of Uncertain Malignant Potential (Sump): A 3-Year Institutional Experience, Christopher M Cormier, Shweta Agarwal

Pathology Research and Scholarship

BACKGROUND: Fine-needle aspiration (FNA) is the preferred diagnostic test for salivary gland lesions. The purpose of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is to standardize salivary gland cytology reporting and guide treatment decisions. The objective of the current study was to evaluate the utility and performance of the MSRSGC, with a focus on the cytomorphology of lesions diagnosed as atypia of undetermined significance (AUS) and salivary gland neoplasm of uncertain malignant potential (SUMP).

METHODS: In total, 123 salivary gland FNAs were included in the study. FNA diagnoses for all cases were reviewed and recategorized, as applicable, according …

Ba/Md 2022 Apr Self-Study & Documents, Unm

UNM Academic Program Review

UNM Combined BA/MD APR self-study report, review team report, response to review report, and initial action plan for Spring 2022, fulfilling requirements of the Higher Learning Commission.

Femur Morphology In Healthy Infants And Young Children, Nathan P. Brown, Angela Thompson, Karen Bertocci, Natalie L. Adolphi, Lauren Dvorscak, Mary Clyde Pierce, Gina Bertocci

Pathology Research and Scholarship

The objective of this study was to characterize femur morphology in healthy infants and young children. Anterior-posterior (AP) radiographs of the femur from children age 0-3 years with no history of bone disease were obtained from two children's hospitals and one medical examiner's office. Femur morphological measures (bone length, minimum diaphysis diameter, growth plate width, and femur radius of curvature) and sectional structural measures were determined. Measures were described and compared based on subject age and mass. Relationships between measures and age and mass were evaluated. The 169 AP femur radiographs were obtained from 99 children (59.6% males, median age …

Estimation Of Radium-226 Concentrations In Produced Water From Shale Gas, Tight Gas And Conventional Hydrocarbon Wells, Richard Frank Haaker

Mathematics & Statistics ETDs

This study examined data from the United States Geological Survey Produced Water database, version 2.3 (USGS DB) and built models to estimate the concentration of radium-226 in produced water given the values of other predictor variables. The dataset had only about 254 observations that were useable. Although the USGS DB had up to 190 possible attributes, it also had extreme rates of missingness, and many of the candidate variables were highly correlated. Multiple imputation techniques were employed using the Mice, Hmisc, and RMS packages for the R language to deal with the missing data. A multiple linear regression and two …

Diatom Response To Different Hydrologic Sources In Alpine Streams: A Teton Range Case Study, Shannon Weld

Water Resources Professional Project Reports

Alpine stream diversity is due in part to different hydrological sources including snowpack, surface glaciers, and rock glaciers; climate change threatens to homogenize these sources. Surprisingly little is understood about algal communities in these stream types. We characterized algal communities and water chemistry among ten alpine streams from these sources in the Teton Range, Wyoming, USA. Late summer sampling (2019-2021) included diatoms, anions, cations, and water quality parameters. Data were analyzed using one- and two-way analysis of variance, principal component analysis, and nonmetric multidimensional scaling. There were statistically significant differences among some or all hydrologic sources for temperature, dissolved oxygen, …

3d Library From Body Size From Unconventional Specimens: A 3d Geometric Morphometrics Approach To Fishes From Ancestral Pueblo Contexts, Jonathan Dombrosky, Thomas F. Turner, Alexandra Harris, Emily Lena Jones

Anthropology Faculty & Staff Publications

Animal body size estimation from zooarchaeological specimens often relies on specific, one-dimensional (i.e., conventional) measures from skeletal elements. Here, we introduce an animal body size estimation technique for archaeological fishes that relies on 3D reference scans and the calculation of centroid size, a standard 3D geometric morphometric proxy measure for organism size. Centroid size-based estimations on whole caudal vertebrae are strongly correlated with a widely accepted measure (i.e., centrum width), but the scalability and flexibility of the centroid size-based approach allows for use on a wide variety of fragmented remains. We use zooarchaeological fish remains (subfamily Ictiobinae) from late pre-Hispanic …

Hydrocortisone To Improve Survival Without Bronchopulmonary Dysplasia, Kristi L. Watterberg, Michele C. Walsh, Lei Li, Sanjay Chawla, Carl T. D'Angio, Ronald N Goldberg, Susan R. Hintz, Matthew M Laughon, Bradley A. Yoder, Kathleen A. Kennedy, Georgia E. Mcdavid, Conra Backstrom-Lacy, Abhik Das, Margaret M. Crawford, Martin Keszler, Gregory M. Sokol, Brenda B. Poindexter, Namasivayam Ambalavanan, Anna Maria Hibbs, William E. Truog, Barbara Schmidt, Myra H. Wyckoff, Amir M. Khan, Meena Garg, Patricia R. Chess, Anne M. Reynolds, Mohannad Moallem, Edward F. Bell, Lauritz R. Meyer, Ravi M. Patel, Krisa P. Van Meurs, C Michael Cotten, Elisabeth C. Mcgowan, Abbey C. Hines, Stephanie Merhar, Myriam Peralta-Carcelen, Deanne E. Wilson-Costello, Howard W. Kilbride, Sara B. Demauro, Roy J. Heyne, Ricardo A. Mosquera, Girija Natarajan, Isabell B. Purdy, Jean R. Lowe, Nathalie L. Maitre, Heidi M. Harmon, Laurie A. Hogden, Ira Adams-Chapman, Sarah Winter, William F. Malcolm, Rosemary D. Higgins, Eunice Kennedy Shriver Nichd Neonatal Research Network

Pediatrics Research and Scholarship

BACKGROUND: Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment after the second postnatal week can improve survival without bronchopulmonary dysplasia and without adverse neurodevelopmental effects is unknown.

METHODS: We conducted a trial involving infants who had a gestational age of less than 30 weeks and who had been intubated for at least 7 days at 14 to 28 days. Infants were randomly assigned to receive either hydrocortisone (4 mg per kilogram of body weight per day tapered over a period of 10 days) or placebo. Mandatory …

20220318_Let's Talk About Menstrual Equity, Varina Kosovich

HSLIC Blog Post

No abstract provided.

Interview With Jay Chavez About Jay Chavez, Tamara M. Motley

Making History Oral Histories

This interview documents the life and hobbies of UNM student Jay Chavez.

Phase I Treatability Study Report For In-Situ Bioremediation At The Technical Area-V Groundwater Area Of Concern, March 2022, Sandia National Laboratories/Nm

Environmental Restoration

To test an active remedy for treating the groundwater contamination at the Technical Area-V (TA-V) Groundwater (TAVG) Area of Concern (AOC), the U.S. Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories, New Mexico (SNL/NM) personnel implemented a Treatability Study of In-Situ Bioremediation (ISB) to remediate the two constituents of concern, trichloroethene (TCE) and nitrate. Both contaminants were detected in the groundwater at TA-V at concentrations above their respective U.S. Environmental Protection Agency (EPA) maximum contaminant levels (MCLs). The EPA MCLsare the cleanup goals for groundwater remediation at the TAVG AOC as specified in the Compliance Order on …

Non-Autophagy Role Of Atg5 And Nbr1 In Unconventional Secretion Of Il-12 Prevents Gut Dysbiosis And Inflammation, Seth D. Merkley, Samuel M. Goodfellow, Yan Guo, Zoe E R Wilton, Janie R. Byrum, Kurt C. Schwalm, Darrell L. Dinwiddie, Rama R. Gullapalli, Vojo Deretic, Anthony Jimenez Hernandez, Steven B. Bradfute, Julie G. In, Eliseo F. Castillo

Pediatrics Research and Scholarship

Intestinal myeloid cells play a critical role in balancing intestinal homeostasis and inflammation. Here, we report that expression of the autophagy-related 5 [Atg5] protein in myeloid cells prevents dysbiosis and excessive intestinal inflammation by limiting IL-12 production. Mice with a selective genetic deletion of Atg5 in myeloid cells [Atg5ΔMye] showed signs of dysbiosis preceding colitis, and exhibited severe intestinal inflammation upon colitis induction that was characterised by increased IFNγ production. The exacerbated colitis was linked to excess IL-12 secretion from Atg5-deficient myeloid cells and gut dysbiosis. Restoration of the intestinal microbiota or genetic deletion of IL-12 in Atg5ΔMye mice attenuated …

Long-Term Monitoring And Maintenance Plan For The Mixed Waste Landfill - March 2012, Revision I February 16, 2022, Sandia National Laboratories/Nm

Facilities-Units

This Revision I_February 16, 2022 version of the Long-term Monitoring and Maintenance Plan for the Mixed Waste Landfill replaces the original March, 2012 MWL LTMMP.

Corrigendum To "Unraveling The Mechanobiology Of Immune Cells" [Curr Opin Biotechnol 66 (2020) 236-245], Xuexiang Zhang, Tae-Hyung Kim, Timothy J. Thauland, Hongjun Li, Fatemeh Sadat Majedi, Chau Ly, Zhen Gu, Manish J. Butte, Amy C. Rowat, Song Li

Pathology Research and Scholarship

Immune cells can sense and respond to biophysical cues — from dynamic forces to spatial features — during their development, activation, differentiation and expansion. These biophysical signals regulate a variety of immune cell functions such as leukocyte extravasation, macrophage polarization, T cell selection and T cell activation. Recent studies have advanced our understanding on immune responses to biophysical cues and the underlying mechanisms of mechanotransduction, which provides rational basis for the design and development of immune-modulatory therapeutics. This review discusses the recent progress in mechanosensing and mechanotransduction of immune cells, particularly monocytes/macrophages and T lymphocytes, and features new biomaterial designs …

The Role Of The Accessory Gene Regulator Operon In Biofilm Formation By Staphylococcus Aureus, Sarah C. Jordan

Pharmaceutical Sciences ETDs

Staphylococcus aureus is a pathogenic bacteria that causes significant morbidity and mortality. As antibiotic resistance by S. aureus continues to be a serious concern, developing novel drug therapies to combat these infections is vital. Quorum sensing inhibitors (QSI) dampen S. aureus virulence and facilitate clearance by the host immune system by blocking quorum sensing signaling that promotes upregulation of the accessory gene regulator (agr) operon. While QSIs have shown therapeutic promise in mouse models of S. aureus infection, their further development has been hampered by the suggestion that agr inhibition promotes biofilm formation. In these studies, we investigated the relationship …

Clinical Performance Of Methylation As A Biomarker For Cervical Carcinoma In Situ And Cancer Diagnosis: A Worldwide Study, Cristiana Banila, Attila T. Lorincz, Dorota Scibior-Bentkowska, Gary M. Clifford, Birhanu Kumbi, Dereje Beyene, Cosette M. Wheeler, Kate Cuschieri, Jack Cuzick, Belinda Nedjai

Pathology Research and Scholarship

The shift towards primary human papillomavirus (HPV)-based screening has necessitated the search for a secondary triage test that provides sufficient sensitivity to detect high-grade cervical intraepithelial neoplasia (CIN) and cancer, but also brings an improved specificity to avoid unnecessary clinical work and colposcopy referrals. We evaluated the performance of the previously described DNA-methylation test (S5) in detecting CIN3 and cancers from diverse geographic settings in high-, medium- and low-income countries, using the cut-off of 0.80 and exploratory cut-offs of 2.62 and 3.70. Assays were performed using exfoliated cervical specimens (n = 808) and formalin-fixed biopsies (n = 166) from women …

A Review Of Environmental Vulnerabilities Related To Nepal’S Graduation Process From Least Developed To A Developing Country Status, Ambika P. Adhikari, Keshav Bhattarai, Basu Sharma

Himalayan Research Papers Archive

Nepal has long aspired to graduate from the Least Development Country (LDC) to Developing Country category as defined by the United Nations system. Nepal had met two of the three graduating criteria and could have technically graduated from the LDC status in 2015. However, based on the Nepal government’s request to defer the review, the new 2021 assessment by the United Nations Committee for Development Policy (CDP) recommended that the country should graduate from the LDC status by 2026. The graduation requires not only meeting pre-defined development-related thresholds, but also maintaining sustained improvements in at least two consecutive assessments in …

Immunogenicity And Protective Capacity Of A Virus-Like Particle Vaccine Against Chlamydia Trachomatis Type 3 Secretion System Tip Protein, Ct584, Everett Webster, Kyra W. Seiger, Susan B. Core, Amanda L. Collar, Hannah Knapp-Broas, June Graham, Muskan Shrestha, Sarah Afzaal, William M. Geisler, Cosette M. Wheeler, Bryce Chackerian, Kathryn M. Frietze, Rebeccah S. Lijek

Pathology Research and Scholarship

An effective vaccine against Chlamydia trachomatis is urgently needed as infection rates continue to rise and C. trachomatis causes reproductive morbidity. An obligate intracellular pathogen, C. trachomatis employs a type 3 secretion system (T3SS) for host cell entry. The tip of the injectosome is composed of the protein CT584, which represents a potential target for neutralization with vaccine-induced antibody. Here, we investigate the immunogenicity and efficacy of a vaccine made of CT584 epitopes coupled to a bacteriophage virus-like particle (VLP), a novel platform for Chlamydia vaccines modeled on the success of HPV vaccines. Female mice were immunized intramuscularly, challenged transcervically …

Groundwater Law, The San Luis Valley, And Climate Change, Rachel Grabenstein

Student Published Scholarship

A vast region of the western United States is in the grips of the first climate change-induced megadrought observed in the past 1,200 years.

This paper explores how climate change and the current groundwater legal regimes interact in Colorado’s San Luis Valley. The Valley was chosen as a case study because it is an example of a community that introduced voluntary measures to address the overuse of groundwater. This paper examines how those measures might have been sufficient if not for the additional challenge of climate change.

This paper will first explain the history of water management in the Valley. …

Beyond Bake Sales: Environmental Justice Through Superfund Removal Actions, Clifford Villa

Faculty Scholarship

Few people outside of EPA seem to be aware of the existence of the Superfund removal program, a program through which millions of dollars are allocated through EPA’s ten regional offices each year for cleaning up contaminated sites that are not designated 'Superfund' sites. This essay will provide a basic introduction to the Superfund removal program and particularly encourage consideration of Superfund removals to address growing concerns for environmental justice. Part II examines the legal authorities and limitations of the Superfund removal program. Part III provides examples of removal actions in environmental justice communities across the country. Part IV considers …

Adapting To A 4°C World, Clifford Villa

Faculty Scholarship

The Paris Agreement’s goal to hold warming to 1.5°-2°C above pre-industrial levels now appears unrealistic. Profs. Robin Kundis Craig and J.B. Ruhl have recently argued that because a 4°C world may be likely, we must recognize the disruptive consequences of such a world and respond by reimagining governance structures to meet the challenges of adapting to it. In this latest in a biannual series of essays, they and other members of the Environmental Law Collaborative explore what 4°C might mean for a variety of current legal doctrines, planning policies, governance structures, and institutions.

Unm Pathology Pathfinder Winter 2022, Unm Department Of Pathology

Newsletters

No abstract provided.

Psychedelic Therapies At The Crossroads Of Trauma And Substance Use: Historical Perspectives And Future Directions, Taking A Lead From New Mexico, Snehal R. Bhatt, Maya Armstrong, Tassy Parker, Marcello Maviglia, Rebecca Kass, Lawrence Leeman, Paul Romo, Douglas Ziedonis

Family and Community Medicine Research and Scholarship

Post-traumatic stress disorder (PTSD), a common condition with potentially devastating individual, family, and societal consequences, is highly associated with substance use disorders (SUDs). The association between PTSD and SUD is complex and may involve adverse childhood experiences (ACEs), historical and multi-generational traumas, and social determinants of health as well as cultural and spiritual contexts. Current psychosocial and pharmacological treatments for PTSD are only modestly effective, and there is a need for more research on therapeutic interventions for co-occurring PTSD and SUD, including whether to provide integrated or sequential treatments. There is a current resurgence of interest in psychedelics as potential …

Investigating Mechanistic Pathways Involved In Neuroimmune Dysregulation And Neuropathic Pain Susceptibility Due To Prenatal Alcohol Exposure, Ariana Pritha, Joshua J. Sanchez, Jacob E. Sanchez, Suzy Davies, Daniel D. Savage, Nikolaos Mellios, Shahani Noor, Erin D. Milligan

Brain & Behavioral Health Research Day

Neuropathic pain is a chronic pain condition resulting from damaged peripheral nerves that induces allodynia (pathological touch sensitivity). Our previous studies suggest that prenatal alcohol exposure (PAE) is a risk factor for allodynia. In contrast to control rats, adult PAE rats with minimal nerve injury develop allodynia. Nerve-injured PAE rats display heightened peripheral and central nervous system (CNS) immune cell-derived proinflammatory cytokine production that consequently results in allodynia. This suggests that PAE dysregulates peripheral immune and CNS glial cell function to over-respond to subtle immune challenges leading to allodynia. However, gene expression profiles underlying dysregulated neuroimmune activity due to PAE …

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2022, Michael Haederle, Sara Mota, El Webb, Chris Corrie, Byron Hughey-Geer, Jett Loe, Sarah Head, Elizabeth Sandlin

Research Annual Reports

No abstract provided.

Giardial Lipid Rafts Share Virulence Factors With Secreted Vesicles And Participate In Parasitic Infection In Mice, Brian I. Grajeda, Atasi De Chatterjee, Carmen M. Villalobos, Breanna C. Pence, Cameron C. Ellis, Vanessa Enriquez, Sourav Roy, Sukla Roychowdhury, Aaron K. Neumann, Igor C. Almeida, Steven E. Patterson, Siddhartha Das

Pathology Research and Scholarship

Giardia lamblia, a protozoan parasite, is a major cause of waterborne infection, worldwide. While the trophozoite form of this parasite induces pathological symptoms in the gut, the cyst form transmits the infection. Since Giardia is a noninvasive parasite, the actual mechanism by which it causes disease remains elusive. We have previously reported that Giardia assembles cholesterol and GM1 glycosphingolipid-enriched lipid rafts (LRs) that participate in encystation and cyst production. To further delineate the role of LRs in pathogenesis, we isolated LRs from Giardia and subjected them to proteomic analysis. Various cellular proteins including potential virulence factors-e.g., giardins, variant surface …