Digital Commons Network^™

A Multicultural Study Of The Experience Of Grief Following Involuntary Job Loss, Diane Lacen

Individual, Family, and Community Education ETDs

A MULTICULTURAL STUDY OF THE EXPERIENCE OF GRIEF FOLLOWING INVOLUNTARY JOB LOSS

by DIANE BYRD LACEN

B. A., English, The University of New Mexico, 1989 M. A., Secondary Education, The University of New Mexico, 1996 M. A., Counseling and Guidance, New Mexico Highlands University, 2005 Ph.D., Counselor Education, The University of New Mexico, 2020

ABSTRACT

Unemployment affects many individuals and families in today’s world. This qualitative multiple-case study design examined how individuals from diverse backgrounds experienced grief following involuntary job loss. A purposeful sampling consisted of nine adults who represented the multicultural diversity in New Mexico. Triangulation of methods included …

The Role Of Hud In Alternative Splicing And Alternative Polyadenylation In The Brain, Rebecca M. Sena

Biomedical Sciences ETDs

RNA binding proteins (RBPs) regulate several processes in the cell, including alternative splicing and alternative polyadenylation. Hu proteins, a class of ELAV-like RBPs, are crucial for proper development and maintenance of the nervous system. Several Hu proteins, including HuD, have been shown to regulate alternative splicing and alternative polyadenylation of neuronal transcripts. However, previous studies have relied on molecular techniques to analyze individual transcripts, which do not provide a global overview of the transcriptome. The purpose of this study was to develop a bioinformatics pipeline to analyze splicing and polyadenylation using RNA-sequencing data. Once the pipeline was developed, it was …

Transfusion Of Blood Components Containing Abo-Incompatible Plasma Does Not Lead To Higher Mortality In Civilian Trauma Patients, Jansen N. Seheult, Nancy M. Dunbar, John R. Hess, Erin E. Tuott, Mohammad Bahmanyar, Jessica Campbell, Magali Fontaine, Jenna Khan, Ara Ko, Jian Mi, Michael F. Murphy, Tara Nykoluk, Jessica Poisson, Jay S. Raval, Andrew Shih, Jason L. Sperry, Julie Staves, Michelle Wong, Matthew T S Yan, Alyssa Ziman, Mark H. Yazer

Pathology Research and Scholarship

BACKGROUND: This study investigated the effect on mortality of transfusing ABO-incompatible plasma from all sources during trauma resuscitation.

METHODS: Demographic, transfusion, and survival data were retrospectively extracted on civilian trauma patients. Patients were divided by receipt of any quantity of ABO-incompatible plasma from any blood product (incompatible group) or receipt of solely ABO-compatible plasma (compatible group). The primary outcome was 30-day mortality, while other outcomes included 6- and 24-hour mortality. Mixed-effects logistic regression was used to model the effect of various predictor variables, including receipt of incompatible plasma, on mortality outcomes.

RESULTS: Nine hospitals contributed data on a total of …

Plasmon-Induced Color And Photochemistry, Paul J. Gieri

Nanoscience and Microsystems ETDs

In recent decades, metallic nanostructures have been extensively studied for a variety of applications due to the ability to support surface plasmons. These excitations, which consist of collective resonant oscillations of the conduction electrons, couple strongly to visible light, confining it into subwavelength volumes. In the first part of this work, we study the optical response of metallic nanostructures supported by metallic substrates. We demonstrate that these systems support a charge transfer plasmon mode, whose frequency is primarily determined by the geometry of the contact area between the nanoparticle and the substrate. In the following part, we exploit this knowledge …

Factors Related To Retention And Self-Efficacy Of Special Education Teachers Working With Students With Autism Spectrum Disorder In Tabuk-Saudi Arabia: Teachers’ Interviews, Abdullah M. Alatawi

Special Education ETDs

Special educators' self-efficacy and retention may be negatively impacted due to many factors related to work conditions and internal factors related to teachers themselves. In this qualitative methodology, I aimed to explore factors that influence teachers of students with autism spectrum disorder (ASD) to stay in their careers and factors affecting their self-efficacy to teach students with autism in Tabuk-Saudi Arabia. This study was based upon Bandura's theoretical construct of self-efficacy and conceptual models of special educators' retention. Six participants: four male and two female special educators participated in semi-structured interviews. After using the qualitative data analysis program Dedoose to …

Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibody Titers In Convalescent Plasma And Recipients In New Mexico: An Open Treatment Study In Patients With Coronavirus Disease 2019, Steven B. Bradfute, Ivy Hurwitz, Alexandra V. Yingling, Chunyan Ye, Qiuying Cheng, Timothy P Noonan, Jay S. Raval, Nestor R. Sosa, Gregory J. Mertz, Douglas J. Perkins, Michelle S. Harkins

Pathology Research and Scholarship

BACKGROUND: Convalescent plasma (CP) is a potentially important therapy for coronavirus disease 2019 (COVID-19). However, knowledge regarding neutralizing antibody (NAb) titers in donor plasma and their impact in patients with acute COVID-19 remains largely undetermined. We measured NAb titers in CP and in patients with acute COVID-19 before and after transfusion through the traditional Food and Drug Administration investigational new drug pathway.

METHODS: We performed a single-arm interventional trial measuring NAb and total antibody titers before and after CP transfusion over a 14-day period in hospitalized patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection.

RESULTS: NAb titers in …

Pyrazole-Based Lactate Dehydrogenase Inhibitors With Optimized Cell Activity And Pharmacokinetic Properties, Ganesha Rai, Daniel J. Urban, Bryan T. Mott, Xin Hu, Shyh-Ming Yang, Gloria A. Benavides, Michelle S. Johnson, Giuseppe L. Squadrito, Kyle R. Brimacombe, Tobie D. Lee, Dorian M. Cheff, Hu Zhu, Mark J. Henderson, Katherine Pohida, Gary A. Sulikowski, David M. Dranow, Md Kabir, Pranav Shah, Elias Padilha, Dingyin Tao, Yuhong Fang, Plamen P. Christov, Kwangho Kim, Somnath Jana, Pavan Muttil, Tamara Anderson, Nitesh K Kunda, Helen J. Hathaway, Donna F. Kusewitt, Nobu Oshima, Murali Cherukuri, Douglas R. Davies, Jeffrey P. Norenberg, Larry A. Sklar, William J. Moore, Chi V Dang, Gordon M. Stott, Leonard Neckers, Andrew J. Flint, Victor M. Darley-Usmar, Anton Simeonov, Alex G. Waterson, Ajit Jadhav, Matthew D. Hall, David J. Maloney

Pathology Research and Scholarship

Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plasticity of cancer cells and has long been recognized as a potential therapeutic target. Thus, potent, selective inhibitors of LDH represent an attractive therapeutic approach. However, to date, pharmacological agents have failed to achieve significant target engagement in vivo, possibly because the protein is present in cells at very high concentrations. We report herein a lead optimization campaign focused on a pyrazole-based series of compounds, …

Ms4 Swmpp 2020, National Technology & Engineering Solutions Of Sandia, Llc (Ntess) And Department Of Energy (Doe)

Municipal Separate Storm Sewer System (MS4) Permit

Stormwater discharges from industrial activities at Sandia National Laboratories/New Mexico (SNL/NM) are eligible for coverage under the National Pollutant Discharge Elimination System (NPDES) Multi-Sector General Permit (MSGP). This Stormwater Pollution Prevention Plan (SWPPP) was prepared by National Technology and Engineering Solutions of Sandia (NTESS) for the Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia Field Office (SFO), owner of SNL/NM, located in Albuquerque, NM. This SWPPP was prepared in compliance with the 2015 MSGP (effective June 4, 2015) and includes a description, potential pollutant sources, and control measures for each permitted site; and stormwater monitoring and compliance plans.

At Three Years, Patients With Acute Lymphoblastic Leukaemia Are Still At Risk For Relapse. Results Of The International Mrc Ukallxii/Ecog E2993 Trial, Chezi Ganzel, Xin V. Wang, Jacob M. Rowe, Susan M. Richards, Georgina Buck, David I. Marks, Mark R. Litzow, Elisabeth M. Paietta, Letizia Foroni, Selina M. Luger, Cheryl L. Willman, Charles G. Mullighan, Kathryn G. Roberts, Peter H. Wiernik, Dan Douer, Hillard M. Lazarus, Martin S. Tallman, Anthony H. Goldstone

Pathology Research and Scholarship

Late relapse [>3 years from complete remission (CR)] in acute lymphoblastic leukaemia (ALL), is unusual. Data from the MRC UKALLXII/ECOG E2993 trial are presented to evaluate the incidence and characteristics of late relapse in adult ALL. Of 1,909 patients, 1,752 (92%) achieved CR and among these 757 (43·2%) relapsed; 691 (91·3%) within three years and 66 (8·7%) beyond. Among these 66 patients, median time to relapse was 47 (37-144) months. Relapse beyond three years occurred in 3·8% of all who achieved CR. The cumulative risk of relapse was 40%, 43% and 45% at three, five and ten years respectively. …

Issue 9, Fall 2020, University Libraries

University Libraries Employee Newsletters

Content:

Employee Spotlight: Carol Kennedy

Welcome to New Employees

• Holly Surbaugh
• Stephanie Moore
• Carol Kennedy

• Arianne Avery
• Olivia Baca
• Brett Nafziger
• Margie Montanez
• Bennett Poulin
• Laura Soito

Comparing Deep Learning And Immunohistochemistry In Determining The Site Of Origin For Well-Differentiated Neuroendocrine Tumors, Jordan Redemann, Fred A. Schultz, Cathy Martinez, Michael Harrell, Douglas P. Clark, David R. Martin, Joshua A. Hanson

Pathology Research and Scholarship

Background: Determining the site of origin for metastatic well-differentiated neuroendocrine tumors (WDNETs) is challenging, and immunohistochemical (IHC) profiles do not always lead to a definitive diagnosis. We sought to determine if a deep-learning convolutional neural network (CNN) could improve upon established IHC profiles in predicting the site of origin in a cohort of WDNETs from the common primary sites.

Materials and methods: Hematoxylin and eosin (H&E)-stained tissue microarrays (TMAs) were created using 215 WDNETs arising from the known primary sites. A CNN trained and tested on 60% (n = 130) and 40% (n = 85) of these cases, …

Soft Subring Theory Under Interval-Valued Neutrosophic Environment, Sudipta Gayen, Florentin Smarandache, Sripati Jha, Manoranjan Kumar Singh, Said Broumi, Ranjan Kumar

Neutrosophic Sets and Systems

No abstract provided.

The Relationships Between Benthic Macroinvertebrate And Local Water Quality And Physical Habitat Characteristics In The Rio Chama, New Mexico, Monika Hobbs

Water Resources Professional Project Reports

Incorporating the process of adaptive management in rivers management can assist with mitigating impacts of altered streamflow and prevent loss of aquatic biodiversity. Streamflow regimes are important drivers of stream ecology and structuring adaptive management around benthic macroinvertebrates could be an efficient means to understand ecological responses to management of streamflow regime. Over the past decade, there has been interest in implementing adaptive management practices to managing stream flow in the Rio Chama below El Vado Dam in northern New Mexico. The goal of this research project is to improve understanding of environmental drivers shape the benthic macroinvertebrate communities in …

Antibodies To Variable Domain 4 Linear Epitopes Of The Chlamydia Trachomatis Major Outer Membrane Protein Are Not Associated With Chlamydia Resolution Or Reinfection In Women, Amanda L. Collar, Alexandria C. Linville, Susan B. Core, Cosette M. Wheeler, William M. Geisler, David S. Peabody, Bryce Chackerian, Kathryn M. Frietze

Pathology Research and Scholarship

Chlamydia trachomatis is an obligate intracellular bacterium. C. trachomatis infection is the most prevalent bacterial sexually transmitted infection and can lead to pelvic inflammatory disease and infertility in women. There is no licensed vaccine for C. trachomatis prevention, in part due to gaps in our knowledge of C. trachomatis-specific immune responses elicited during human infections. Previous investigations of the antibody response to C. trachomatis have identified immunodominant antigens and antibodies that can neutralize infection in cell culture. However, epitope-specific responses to C. trachomatis are not well characterized, and the impact of these antibodies on infection outcome is unknown. We …

Faunal Remains From Archaeology Sites In Southwestern New Mexico, Karen Gust Schollmeyer, S. O. Macdonald

Occasional Papers

This study attempts to create a comprehensive catalog of all known records of faunal remains recovered from 105 archaeological sites located across southwestern New Mexico. These sites range in age from 2000BC to AD 1450. Approximately 250 taxa of mollusks, fishes, amphibians, reptiles, birds and mammals are represented in this compilation. Primary reference materials from published and unpublished sources are included, along with the repositories where relevant collections may be found for potential reexamination by researchers from a variety of fields of interest.

Introducing The Self-Cleaning Filtration For Water Quality Sensors (Sc-Flawless) System, Aashish Sanjay Khandelwal

Civil Engineering ETDs

Sensor-based, semi-continuous observations of water quality parameters have become critical to understanding how changes in land use, management, and rainfall-runoff processes impact water quality at diurnal to multi-decadal scales. While some commercially available water quality sensors function adequately under a range of turbidity conditions, other instruments, including those used to measure nutrient concentrations, cease to function in high turbidity waters (> 100 NTU) commonly found in large rivers, arid-land rivers, and coastal areas. This is particularly true during storm events, when increases in turbidity are often concurrent with increases in nutrient transport. Here, we present the development and validation of …

Heterogeneity Of Mild To Moderate Persistent Asthma In Children: Confirmation By Latent Class Analysis And Association With 1-Year Outcomes, Anne M. Fitzpatrick, Leonard B. Bacharier, Daniel J. Jackson, Stanley J. Szefler, Avraham Beigelman, Michael Cabana, Ronina Covar, Theresa Guilbert, Fernando Holguin, Robert F. Lemanske, Fernando D. Martinez, Wayne Morgan, Wanda Phipatanakul, Jacqueline A. Pongracic, Hengameh H. Raissy, Robert S. Zeiger, David T. Mauger

Pediatrics Research and Scholarship

BACKGROUND: Compared with adults, phenotypic characterization of children with asthma is still limited and it remains difficult to predict which children with asthma are at highest risk for poor outcomes.

OBJECTIVE: To identify latent classes in a large population of treatment-adherent children with mild to moderate asthma enrolled in clinical trials and determine whether latent class assignment predicts future lung function abnormalities and exacerbation rate.

METHODS: Latent class analysis was performed on 2593 children with mild to moderate asthma aged 5 18 years, with 19 variables encompassing demographic characteristics, medical history, symptoms, lung function, allergic sensitization, and type 2 inflammation. …

Self-Regulation And Emotional Reactivity In Infants With Prenatal Exposure To Opioids And Alcohol, Kathryn G Beauchamp, Jean Lowe, Ronald M Schrader, Shikhar Shrestha, Crystal Aragón, Natalia Moss, Julia M Stephen, Ludmila N Bakhireva

Pediatrics Research and Scholarship

BACKGROUND: Infants with prenatal substance exposure are at increased risk for developmental problems, with self-regulatory challenges being some of the most pronounced. The current study aimed to investigate the extent to which prenatal substance exposure (alcohol, opioids) impacts infant self-regulation during a relational stressor and the association between self-regulation and infant affect.

METHODS: Participants were 100 mother-child dyads recruited prenatally (Mean = 23.8 gestational weeks) and completed the Still Face Paradigm (SFP) when infants were 5 to 8 months of age (Mean = 6.9 months) as part of an ENRICH prospective birth cohort study. Based on prospective repeated assessment of …

Covid-19 And Telehealth, Education, And Research Adaptations., N Romesh Wijesooriya, Vimal Mishra, Paul L P Brand, Bruce K Rubin

Project ECHO Bibliography

For decades, there have been government funded services to provide healthcare telephonically to remote sites both on the earth and in the air. This capability has evolved into what we now know as telehealth. The use of telehealth dramatically accelerated as a result of concerns for patient and healthcare provider safety during the SARS-CoV2 pandemic. Similarly, concerns regarding transmission of infection have required medical schools to provide robust, easily accessible virtual education options. At short notice, faculties have had to develop new telehealth focused curriculum components. However, telehealth, online education, and internet enabled research should not be simply a new …

Γ9Δ2t Cell Diversity And The Receptor Interface With Tumor Cells, Anna Vyborova, Dennis X. Beringer, Domenico Fasci, Froso Karaiskaki, Eline Van Diest, Lovro Kramer, Aram De Haas, Jasper Sanders, Anke Janssen, Trudy Straetemans, Daniel Olive, Jeanette Leusen, Lola Boutin, Steven Nedellec, Samantha L. Schwartz, Michael J. Wester, Keith A. Lidke, Emmanuel Scotet, Diane S. Lidke, Albert Jr Heck, Zsolt Sebestyen, Jürgen Kuball

Pathology Research and Scholarship

γ9δ2T cells play a major role in cancer immune surveillance, yet the clinical translation of their in vitro promise remains challenging. To address limitations of previous clinical attempts using expanded γ9δ2T cells, we explored the clonal diversity of γ9δ2T cell repertoires and characterized their target. We demonstrated that only a fraction of expanded γ9δ2T cells was active against cancer cells and that activity of the parental clone, or functional avidity of selected γ9δ2 T cell receptors (γ9δ2TCRs), was not associated with clonal frequency. Furthermore, we analyzed the target-receptor interface and provided a 2-receptor, 3-ligand model. We found that activation was …

A Novel Flow Cytometric Assay To Identify Inhibitors Of Rbpj-Dna Interactions, Robert J. Lake, Mark K. Haynes, Kostiantyn Dreval, Rabeya Bilkis, Larry A. Sklar, Hua-Ying Fan

Pathology Research and Scholarship

Notch signaling is often involved in cancer cell initiation and proliferation. Aberrant Notch activation underlies more than 50% of T-cell acute lymphoblastic leukemia (T-ALL); accordingly, chemicals disrupting Notch signaling are of potential to treat Notch-dependent cancer. Here, we developed a flow cytometry-based high-throughput assay to identify compounds that disrupt the interactions of DNA and RBPJ, the major downstream effector of Notch signaling. From 1492 compounds, we identified 18 compounds that disrupt RBPJ-DNA interactions in a dose-dependent manner. Cell-based assays further revealed that auranofin downregulates Notch-dependent transcription and decreases RBPJ-chromatin interactions in cells. Most strikingly, T-ALL cells that depend on Notch …

Minimizing Surgical Blood Loss At Cesarean Hysterectomy For Placenta Previa With Evidence Of Placenta Increta Or Placenta Percreta: The State Of Play In 2020, John C. Kingdom, Sebastian R. Hobson, Ally Murji, Lisa Allen, Rory C. Windrim, Evelyn Lockhart, Sally L. Collins, Hooman Soleymani Majd, Moiad Alazzam, Feras Naaisa, Alireza A. Shamshirsaz, Michael A. Belfort, Karin A. Fox

Pathology Research and Scholarship

The evolution of multidisciplinary team-based care for women with placenta accreta spectrum disorder has delivered stepwise improvements in clinical outcomes. Central to this overall goal is the ability to limit blood loss at surgery. Placement of inflatable balloons within the pelvic arteries, most commonly in the anterior divisions of the internal iliac arteries, became popular in many centers, at the expense of prolonging surgical care and with attendant risks of vascular injury. In tandem, the need to expose pelvic sidewall anatomy to safely identify the course of the ureters re-popularized the alternative strategy of ligating the same anterior divisions of …

Postmortem Computed Tomography In Firearm Homicides: A Retrospective Case Series, Marloes E M Vester, Kurt B Nolte, Gary M. Hatch, Chandra Y. Gerrard, Reinoud D. Stoel, Rick R. Van Rijn

Pathology Research and Scholarship

Postmortem computed tomography (PMCT) is integrated into the evaluation of decedents in several American medical examiner offices and medicolegal death investigative centers in many other countries. We retrospectively investigated the value of PMCT in a series of firearm homicide cases from a statewide centralized medical examiner's office that occurred during 2016. Autopsies were performed or supervised by board-certified forensic pathologists who reviewed the PMCT scans prior to autopsy. PMCT scans were re-evaluated by a forensic radiologist blinded to the autopsy findings and scored by body region (head-neck, thoracoabdominal, and extremities). Injury discrepancies were scored using a modified Goldman classification and …

Cadmium Exposure Activates Akt/Erk Signaling And Pro-Inflammatory Cox-2 Expression In Human Gallbladder Epithelial Cells Via A Ros Dependent Mechanism, Priyanka Sharma, Trevar S. Caldwell, Megan N. Rivera, Rama R. Gullapalli

Pathology Research and Scholarship

Gallbladder cancer (GBC) is the commonest biliary tract cancer with an ill-defined etiology. We examined the role of Cd+2 exposures in a primary human gallbladder (GB) cell line model in this study. Cd+2 exposures induced decreased cell viability, reactive oxygen species (ROS) generation, altered Akt/ERK signaling pathway activation, PGE2 and COX-2 expression in a human primary gallbladder epithelial cell model. Pharmacological inhibitors were used to determine the key drivers of elevated COX-2 expression due to Cd+2 exposure. Our results show Cd+2 causes a dose- dependent reduction in GB cell viability (EC50 value – 18.6 μM). Dose-dependent activation of phospho-Akt and …

Plithogenic Cubic Sets, Florentin Smarandache, S.P. Priyadharshini, F. Nirmala Irudayam

Branch Mathematics and Statistics Faculty and Staff Publications

In this article, using the concepts of cubic set and plithogenic set, the ideas of plithogenic fuzzy cubic set, plithogenic intuitionistic fuzzy cubic set, plithogenic neutrosophic cubic set are introduced and its corresponding internal and external cubic sets are discussed with examples.

Covid-19: Postmortem Diagnostic And Biosafety Considerations, J Matthew Lacy, Erin G. Brooks, Joshua Akers, Danielle Armstrong, Lauren Decker, Adam Gonzalez, William Humphrey, Romana Mayer, Matthew Miller, Catherine Perez, Jose Antonio Ruiz Arango, Lakshmanan Sathyavagiswaran, Wendy Stroh, Suzanne Utley

Pathology Research and Scholarship

As a result of the 2019 novel human coronavirus (COVID-19) global spread, medical examiner/coroner offices will inevitably encounter increased numbers of COVID-19-infected decedents at autopsy. While in some cases a history of fever and/or respiratory distress (eg, cough or shortness of breath) may suggest the diagnosis, epidemiologic studies indicate that the majority of individuals infected with COVID-19 develop mild to no symptoms. Those dying with-but not of-COVID-19 may still be infectious, however. While multiple guidelines have been issued regarding autopsy protocol in cases of suspected COVID-19 deaths, there is some variability in the recommendations. Additionally, limited recommendations to date have …

Dectin-1 Mediated Mechanical Force Generation In Candida Albicans Fungal Pathogen Recognition, Rohan Choraghe

Biomedical Engineering ETDs

Candida spp. pathogens continue to be a major health care burden with high mortality and exceeding a billion dollars in terms of healthcare cost. Candidainfection ranges from superficial dermatological infection to more serious blood stream infection in debilitated patients. One of the major lines of innate immune defense against Candidais phagocytosis. Dectin-1 is the antifungal receptor in myeloid cells responsible for most immune responses against fungi including phagocytosis. We looked into the signaling pathway coordinating this mechanical process downstream of Dectin-1. We found that Dectin-1 activation gives rise to a significant mechanical force generation mediated through RHOA-ROCK-MyosinII pathway. …

Racism In Healthcare, Elizabeth Dwyer

Black History at UNM

Living with the daily experience of racism can have direct, adverse effects on the health and wellbeing of Black, Indigenous, and People of Color (BIPOC) communities. Dr. Tracie Collins, former Dean, UNM College of Population Health, and current Secretary of Health of New Mexico, and Dr. Felisha Rohan-Minjares, Professor, UNM’s Department of Family and Community Medicine, explain how bias and racism impact health, treatment, and outcomes.

Genetic Evidence, Maoa, And State V. Yepez, Nita A. Farahany, Roderick T. Kennedy, Brandon L. Garrett

New Mexico Law Review

This amicus brief offers two main contributions. First, we describe how MAOA studies based on the prior “candidate-gene approach” are unreliable due to inherent flaws in the methodology, leading to inconsistencies in replication. Second, the general scientific consensus has emerged that the earlier MAOA studies (upon which the defense experts relied) are now an outdated method of studying psychiatric genetics. Third, to the extent that recent studies adopting the more rigorous genomewide association studies (GWAS) have attempted to replicate the earlier findings of MAOA candidate-gene studies, they have found no reliable correlation between MAOA and violence.

The Application Of A Middle Range Nursing Theory: Roy’S Adaptation Model, To The Caregivers Of Mental Illness Sufferers, Melanie K. Gibson

Theoretical Foundation in Advanced Practice Nursing

Caregivers of mental illness sufferers need supportive measures from health care providers due to the significant emotional, psychological, and physical burdens of this role. I consider the application of the Roy’s Adaptation Model, a middle-range nursing theory, by the nurse practitioner as a framework for assisting this population. Health care providers can apply these guided interventions to encourage, educate, and achieve the caregiver’s optimal wellbeing and quality of life.