Digital Commons Network^™

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2021, Michael Haederle, Sara Mota, Jana Fothergill, Cindy Foster, Rebecca Roybal Jones, Michele Sequeira, Seth Fuller

Research Annual Reports

No abstract provided.

Metabolic Reprogramming And Cell Adhesion In Acute Leukemia Adaptation To The Cns Niche, Nitesh D. Sharma, Esra'a Keewan, Ksenia Matlawska-Wasowska

Pediatrics Research and Scholarship

Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are associated with a significant risk of short- or long-term toxicities. Leukemic cells can metabolically adapt and survive in the microenvironment of the CNS. The supporting role of the CNS microenvironment in leukemia progression and dissemination has not received sufficient attention. Understanding the mechanism by which leukemic cells survive in the nutrient-poor and oxygen-deprived CNS microenvironment will lead to the development of more specific and less toxic therapies. Here, we review the current literature regarding the roles of metabolic reprogramming …

A Call To Action For Librarians: Countering Conspiracy Theories In The Age Of Qanon, Stephanie Beene, Katie Greer

University Libraries & Learning Sciences Faculty and Staff Publications

Librarians empower learners to become discerning citizens through a set of diverse skills and literacies. To cultivate critical thinkers, librarians continue to build innovative practices, even as technology rapidly evolves. However, the pervasiveness of misinformation and disinformation, most recently seen in the conspiratorial worldviews of QAnon, challenges librarians to center critical thinking in their information literacy praxis. In this article, we provide a concise overview of QAnon and the problems that contemporary internet conspiracy theories like it pose. We offer an epistemological shift for information literacy, from heuristics to mindsets and behaviors, drawing on disciplines external to librarianship. Finally, we …

Unm Pathology Pathfinder Winter 2021, Unm Department Of Pathology

Newsletters

No abstract provided.

Live Imaging Of Brain Network Dynamics In An Acute Threat Response By Memri: Effects Of Early Life Adversity On Noradrenergic System Anatomy, Taylor W. Uselman, Russell E. Jacobs, Elaine L. Bearer

Brain & Behavioral Health Research Day

Monoaminergic signaling in cortical-limbic circuits regulate both normal physiology and responses to stress. Indeed, monoaminergic reuptake transporters, located on the pre-synaptic terminals of distal projections, are common pharmacological targets for mental disorders, like anxiety and depression. Early life adversity (ELA), which has an interaction with monoaminergic systems, increases vulnerability to mental disorders later in life. Despite this, we are yet to understand how ELA alters brain-wide patterns of neural activity. Here, we combine Manganese-enhanced MRI (MEMRI) with behavioral tracking and immunohistochemistry to investigate the effects of ELA on the modular neuroarchitecture and behavioral response to acute threat. ELA was administered …

Proteopathic Tau Primes And Activates Interleukin-1ss (Il-1ss) Via Myd88- And Nlrp3-Asc-Inflammasome Dependent Pathways Cell-Autonomous To Microglia, Shanya Jiang, Nicole M. Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Floruta, Amber Zimmerman, Michael Mandell, Stephen Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason Weick, Eicke Latz, Michael Heneka, Kiran Bhaskar

Brain & Behavioral Health Research Day

Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1ß. First, pTau burden co-exist with elevated IL-1β and inflammasome proteins (NLRP3 and ASC) in autopsy brains of human tauopathies. Suppression of human tau blocks both priming and activation of ASC and NLRP3 in the rTg4510 mouse model of tauopathy. Treating microglia with pTau-containing neuronal media, exosomes or purified human tau tangles causes IL-1β activation, which is NLRP3, ASC, and caspase-1-dependent.

While the microglia-restricted deletion of a common innate immune adaptor protein, MyD88 …

Interactions Between Autophagy, Herpesvirus And Neurodegeneration In Alzheimer’S Disease, Amir Nafchi, Mohammad Anani, Tudor Oprea, Ben Readhead, Elaine Bearer

Brain & Behavioral Health Research Day

Introduction: Various microbes and viruses have been associated with the pathogenesis of Alzheimer’s Diseases (AD), with many studies dating back to the 1950s. There are challenges in establishing direct links between the microbes and AD pathology. Since microbes and viruses have been observed to be dormant and reactivate in aging brains, it is not clear if the microbes are a byproduct of AD pathology or a direct cause of it. Recently, various publications considered the link between several herpes simplex viruses and neurodegeneration in AD. For example, Readhead et al. utilized multiomics data from post-mortem brain samples meeting the neuropathological …

Missing And Murdered Indigenous Women (And Children) – A Global Problem, Hevyn L. Heckes

2022 Award Winners

No abstract provided.

An Impact Evaluation Of Covid-19 Training Program: Knowledge And Awareness Of Public Health Professionals Of Province Five, Nepal, Alok K. Bohara, Swati Thapa, Siobhan K. Yilmaz, Spencer H. Mcbee

Himalayan Research Papers Archive

With the declaration of a worldwide pandemic in March 2020 (World Health Organization 2020), COVID-19 has become a primary focus of governments and public health systems across the world with increases in infection and death rates. By mid-April 2020, more than 80% of countries had imposed containment and mitigation measures. But for developing nations, the threats of this global pandemic are more acute given the lack of resources and the capacity to deal with a shock of this magnitude (Loayza 2020). Despite calling for a lockdown on March 24th, 2020 (Pradhan 2020), Nepal faces several public health challenges including limited …

Pleiotropic Anticoagulant Functions Of Protein S, Consequences For The Clinical Laboratory. Communication From The Ssc Of The Isth, Herm Jan M. Brinkman, Josefin Ahnström, Elisabetta Castoldi, Björn Dahlbäck, Richard A. Marlar

Pathology Research and Scholarship

Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to establish reliable cut-off values. PS has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the activated protein C (APC) and tissue factor pathway inhibitor alpha (TFPIα) cofactor activities. Current clinical laboratory investigations for deficiency in PS function rely only on the APC-dependent activity. This communication presents an argument for reclassifying the qualitative PS deficiencies to differentiate the two major anticoagulant functions of …

Entrustable Professional Activities In Hematopathology Pathology Fellowship Training: Consensus Design And Proposal, Kristie White, Julianne Qualtieri, Elizabeth L. Courville, Rose C. Beck, Bachir Alobeid, David R. Czuchlewski, Julie Teruya-Feldstein, Lorinda A. Soma, Sonam Prakash, Dita Gratzinger

Pathology Research and Scholarship

Hematopathology fellowship education has grown in complexity as patient-centered treatment plans have come to depend on integration of clinical, morphologic, immunophenotypic, molecular, and cytogenetic variables. This complexity is in competition with the need for timely hematopathology care with stewardship of patient, laboratory, and societal resources. Accreditation Council for Graduate Medical Education Milestones provide a guidance document for hematopathology training, but fellows and their educators are in need of a simple framework that allows assessment and feedback of growth toward independent hematopathology practice. Entrustable professional activities provide one such framework, and herein, we provide proposed Hematopathology Fellowship Entrustable Professional Activities based …

Aging And Gender In The Tsimane’: Differences In Energy Expenditure, Physical Activity, And Horticultural Work, Daniel Kruse Cummings

Anthropology ETDs

The purpose of this dissertation is to measure and explain age- and sex-related differences in energy expenditure, physical activity, and patterns of horticultural work, in the Tsimane’, a subsistence forager-horticulturalist population from the Bolivian Amazon. Changes in the way energy is used with advancing age has important implications for the tradeoffs negotiated within the aging body as it partitions increasingly limited energy among competing life functions. It is guided by a theoretical framework which posits the co-evolution of the unique suite of fast and slow human life history traits, cooperative production of resources, and ageand sex-specific schedules of growth, production, …

Bubonic Plague: Public Health Warnings From An Ancient Disease, Mikenzie E. Chessman

2022 Award Winners

No abstract provided.

Molecular Studies On The Interactions Between Biomphalaria Snails And Schistosoma Mansoni, Lijun Lu

Biology ETDs

Biomphalaria snails serve as vectors for Schistosoma mansoni, a trematode causing human schistosomiasis. Control of Schistosoma mansoni involves chemotherapy of affected people, but new control methods built on improved understanding of schistosome-snail interactions are needed. My dissertation applies molecular and bioinformatics approaches to understand such interactions. Chapter 1 shows that significant differences exist among Biomphalaria species in Africa with respect to their ability to support schistosome development. Chapters 2 and 3 reveal the transcriptional responses of Biomphalaria glabrata susceptible (SUS) or resistant (RES) to Schistosoma mansoni. Chapter 2 identifies a new family of snail immune factors, the AIG …

Digital Image Analysis For The Detection Of Group B Streptococcus From Chromid Strepto B Medium Using Phenomatrix Algorithms, Justin Baker, Karen Timm, Matthew Faron, Nathan Ledeboer, Karissa Culbreath

Pathology Research and Scholarship

Group B Streptococcus (GBS) can be found to colonize about 25% of all healthy, adult women and is the leading infectious cause of early neonatal morbidity and mortality in the United States. This study evaluated the clinical performance of PhenoMatrix (PM) chromogenic detection module (CDM) digital imaging software in detection of GBS from LIM broth plated on ChromID Strepto B chromogenic medium (ChromID) using the WASP automated processor. The performance of the PM CDM was compared to manual culture review of the digital images and molecular detection of GBS. ChromID alone had a sensitivity and specificity of 84.5% and 94.7%, …

From A Conventional To An Inclusive Teaching Classroom, David Tadeo Martinez Guido, Gerardo Torres Gutiérrez, Roberto Bernardo Ortiz Gonzalez, Dulce Marisol Arteaga Godoy, Jorge A. Garcia

Research and Development Supported by El Centro

Inclusive education constitutes a point of inclination in policy development and care practices to student populations and social diversity. There are goals and strategies in the Mexican educational system which demonstrate the government’s interest to promote equity and equality opportunities for the entire vulnerable population. These policies are based on the need to recognize the right of people with special educational needs to quality education. Consequently, one of the goals of Plan Nacional de Desarrollo 2019-2024, it is a social policy which has actions to offer education for the entire population and sustainable development.

Therefore, El Tecnológico Nacional de México …

Effects Of Chronic Stress On Anxiety-Like Behavior And Fear Learning In The Tgf344-Ad Rat Model Of Alzheimer’S Disease, Samuel James Bouquin

Psychology ETDs

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder that leads to severe cognitive and functional impairments. Many AD patients also exhibit neuropsychiatric symptoms (NPS) such as anxiety and prior to the clinical diagnosis of dementia. The prodromal manifestation of NPS is highly prevalent among patients with mild cognitive impairment (MCI), and the co-occurrence of preclinical NPS and MCI is associated with an increased risk of developing AD. Prolonged or repeated exposure to stress can result in behavioral disturbances (e.g., anxiety) and accelerated global cognitive decline. Importantly, AD patients exhibit altered stress systems and AD-related neuropathology has been linked to …

Probing The Impacts Of Ultra-Low Platinum Loadings On Membrane Degradation Mechanisms, Andre J. Spears

Nanoscience and Microsystems ETDs

Membrane chemical degradation is one of many factors that can impact fuel cell durability. The fuel cell’s performance and lifetime heavily depends on the membrane and its ability to maintain chemical and mechanical integrity. In Nafion^® membranes, hydroxyl radicals are the primary cause of chemical membrane degradation as they attack the membrane’s polymer structure. Radical formation can ensue via peroxide decomposition at the cathode or gases reacting on Pt particles or contaminants like Fe (a fenton's reagent) within the membrane. As radicals attack the membrane’s polymer structure the membrane thins, and fluoride and sulfate ions are released. This consequently …

Sybil Defense Using Efficient Resource Burning, Diksha Gupta

Computer Science ETDs

In 1993, Dwork and Naor proposed using computational puzzles, a resource burning mechanism, to combat spam email. In the ensuing three decades, resource burning has broadened to include communication capacity, computer memory, and human effort. It has become a well-established tool in distributed security. Due to the cost attached to utilizing resource burning mechanism, these have not been popularized in domains apart from cryptocurrency.

In this dissertation, we design efficient resource burning based Sybil defense techniques for permissionless systems. As a first step, we identify existing resource burning mechanisms in literature in Chapter 2. Additionally, we enumerate numerous open problems …

Dissecting Regulation Mechanism Of Interdomain Electron Transfer In Nitric Oxide Synthases, Huayu Zheng

Chemistry and Chemical Biology ETDs

Nitric oxide (NO) is generated by one of the three isoforms of mammalian NO synthases (NOSs), neuronal, endothelial and inducible NOS (nNOS, eNOS, and iNOS, respectively). Dysregulated NOS is implicated in pathologies of numerous severe diseases including Alzheimer and Parkinson’s diseases. Molecular mechanisms of NOS regulation, once fully understood, are potentially key targets for development of selective new pharmaceuticals for treating these diseases that currently lack effective treatments.

Despite recent developments, there are significant gaps in current understanding of the regulation mechanism of the FMN-heme interdomain electron transfer (IET), an essential step in NOS, by its key regulators such as …

Prenatal Alcohol Exposure Alters Transcriptional Expression Of Stress And Tlr4-Related Immune Signaling Factors In The Brain Following Early Life Stress, Chaselyn D. Ruffaner-Hanson

Biomedical Sciences ETDs

Background: Depression and anxiety disorders, believed to be caused by stress-related neuropeptides and pro-inflammatory molecules in the brain, are prevalent comorbidities of fetal alcohol spectrum disorders (FASD).

Methods: Brain tissue was collected following a 4-hour maternal separation stress during the early postnatal period, postnatal days 10 and 12, from mice subjected to 1^st and 2^nd trimester prenatal alcohol exposure (PAE).

Hypothesis: We hypothesized that PAE leads to glucocorticoid receptor insensitivity, stress molecule overexpression, and potentiated toll-like receptor 4 (TLR4) pathway inflammatory responses in the brain following early life stress.

Results: PAE and stress increased mRNA expression of TLR4 …

Adult Hippocampal Neurogenesis As A Potential Therapeutic Target In Fetal Alcohol Spectrum Disorders, Kymberly Cheyanne Gustus

Biomedical Sciences ETDs

This dissertation aims to determine if adult hippocampal neurogenesis is a potential therapeutic target in Fetal Alcohol Spectrum Disorders (FASDs). Adult hippocampal neurogenesis plays important and unique roles in certain aspects of learning, memory, and mood (Anacker & Hen, 2017). Individuals with FASDs often demonstrate dysregulation in these arenas (Lewis et al., 2015; Temple, Cook, Unsworth, Rajani, & Mela, 2019). Previous work in our lab using a mouse model of prenatal alcohol exposure demonstrated impairment in enrichment-mediated adult hippocampal neurogenesis (Irene Y. Choi, Andrea M. Allan, & Lee Anna Cunningham, 2005; K. Kajimoto, A. Allan, & L. A. Cunningham, 2013). …

Role Of The Acid Sensing Ion Channel 1a In The Systemic Circulation, Selina M. Garcia

Biomedical Sciences ETDs

Acid-sensing ion channel 1a (ASIC1a) is a non-selective cation channel that is expressed in vascular smooth muscle cells. However, little is known about the contribution of ASIC1a to vascular reactivity and cardiovascular homeostasis. We have previously shown that ASIC1a contributes to pulmonary vascular smooth muscle cell (VSMC) Ca²⁺ entry and vasoconstriction as well as chronic hypoxia-induced pulmonary hypertension. However, a role of ASIC1a in the systemic circulation is unclear. Previous reports have shown that ASIC1a is expressed in femoral and cerebral arteries, however, these studies suggest that ASIC1a contributes to vascular reactivity through neuronal regulation rather than vascular. Therefore, …

Hepatitis C Virus Care Cascade In Persons Experiencing Homelessness In The United States In The Era Of Direct-Acting Antiviral Agents: A Scoping Review, Aubrey Del Rosario

Biomedical Sciences ETDs

Background: The Hepatitis C Virus (HCV) care cascade has been well characterized in the general United States population and other subpopulations. However, information is limited on care cascade outcomes in persons experiencing homelessness now that highly effective medications offer the potential for cure.

Objectives: The main objective of this study is to map the available evidence on HCV care cascade outcomes in homeless and marginally housed cohorts in the United States in the era of direct-acting antiviral agents. Primary and secondary outcomes of interest include linkage to care and sustained virologic response. Exploratory outcomes include other care cascade …

The Role Of Anti-Inflammatory Cytokine Interleukin-10 (Il-10) In Tauopathies, Lea L. Weston

Biomedical Sciences ETDs

Tauopathies are neurodegenerative diseases, including Alzheimer’s disease, that are associated with pathological accumulation of the microtubule associated protein tau (MAPT, or tau) (Lee et al., 2001). Abnormal hyperphosphorylated tau (pTau) strongly correlate with cognitive impairment (Nelson et al., 2012). Neuroinflammation is also associated with tauopathies (Gerhard et al., 2006b; Edison et al., 2008) and is implicated in driving tau pathology (Yoshiyama et al., 2007, Maphis et al., 2015b). Therefore, it is compelling to understand the role of anti-inflammatory cytokines in limiting neuroinflammation and tau pathology. Interleukin-10 (IL-10) is a well-established anti-inflammatory cytokine with roles in limiting inflammation in the central …

The First-Year Experiences Of Students In Remedial Classes At A Research University: Implications For Retention And Support, Therese Baca-Radler

Language, Literacy, and Sociocultural Studies ETDs

As more institutions of higher education adopt non-selective admissions processes, an increasing number of students from underrepresented populations are placed into developmental intervention courses as an added requirement to their educational paths based on standardized test scores alone. This study interviewed students who had these requirements imposed upon them and sought to understand their thoughts and feelings about that placement and how it impacted their transition from high school to college and their first-year college success. As students described their prior experiences in formal academic settings, they emphasized the benefits of family support in building their self-directed learning skills and …

Solar Insolation Micro-Forecasts Using Longwave Infrared Sensors And Artificial Intelligence, Anthony R. Menicucci

Mechanical Engineering ETDs

Solar Insolation Micro-Forecasts (SIMF) are used by Independent Service Operators (ISOs) and other grid operators to maintain constant and stable electrical grid frequency, voltage, power factor and waveform across their transmission infrastructure. Intermittent, thick, dense and typically cumulus clouds negatively impact the electrical grid by quickly turning on and off power production from large solar photovoltaic (PV) fields, causing grid stability problems between generation and load. Forecasting insolation values over large PV fields allows operators the chance to anticipate and proactively implement mitigation strategies like engaging spinning reserve from gas turbines, deploying generators, buying power in the spot market, and …

Parental Choice Of Charter Schools For Middle School Students With Disabilities, Oluwole Ilesanmi

Special Education ETDs

For many decades, traditional public schools were the dominant public schools available for educating students, including those with disabilities. However, in the current climate of school choice, parents can now choose from a variety of educational options for their children. This study sought to explore the reasons parents of students with disabilities enrolled their children in charter schools. Research questions addressed the reasons parents considered when enrolling their children with disabilities in charter schools, as well as their degree of satisfaction and experiences after enrollment in charter schools. A total of 108 parents of sixth-eighth grade middle school students with …

Copper Electrodeposition In Full Wafer Thickness Through-Silicon Vias, Rebecca P. Schmitt

Chemical and Biological Engineering ETDs

Through-silicon vias (TSVs) are a key interconnect technology for advanced packaging of microelectronic devices, and full wafer thickness TSVs are required for certain microelectromechanical systems (MEMS) applications. In this work, electrolytes containing copper sulfate, an acid, chloride, and Tetronic 701 suppressor were implemented for Cu filling of high aspect ratio (10:1), full wafer thickness TSVs. For each electrolyte system, rotating disk electrode voltammetry was used to identify a voltage range for bottom-up Cu filling in the TSVs. Die level feature filling was performed using voltage ramping, which moved active deposition through the vias to yield void-free Cu features. During voltage-controlled …

Virtual And In Vitro Antiviral Screening Revive Therapeutic Drugs For Covid-19, Giovanni Bocci, Steven B. Bradfute, Chunyan Ye, Matthew J. Garcia, Jyothi Parvathareddy, Walter Reichard, Surekha Surendranathan, Shruti Bansal, Cristian G. Bologa, Douglas J. Perkins, Colleen B. Jonsson, Tudor I. Oprea, Larry A. Sklar

Pathology Research and Scholarship

The urgent need for a cure for early phase COVID-19 infected patients critically underlines drug repositioning strategies able to efficiently identify new and reliable treatments by merging computational, experimental, and pharmacokinetic expertise. Here we report new potential therapeutics for COVID-19 identified with a combined virtual and experimental screening strategy and selected among already approved drugs. We used hydroxychloroquine (HCQ), one of the most studied drugs in current clinical trials, as a reference template to screen for structural similarity against a library of almost 4000 approved drugs. The top-ranked drugs, based on structural similarity to HCQ, were selected for in vitro …